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High burden of HBV-Infection and atypical HBV strains among HIV-infected Cameroonians
- Source :
- Scopus-Elsevier
-
Abstract
- Aim: To investigate the prevalence and genotypic profile of overt and occult hepatitis-B infection (OBI) among HIV-infected individuals in Cameroon. Methods: 212 HIV-infected Cameroonians, aged 37.6 [IQR: 32.6-46.6] followed-up at the University Health Centre in Yaounde, were tested for HBsAg, anti-HBs, anti-HBc IgG/IgM, HBV-DNA and anti-HCV IgG. HBV positive cases were tested for Hepatitis Delta virus (HDV) using anti-HDV IgG and HDV-RNA. Liver function was assessed by alanine and aspartate aminotransaminases. OBI was defined as negative-HBsAg and detectable HBV-DNA. In occult or overt HBVinfected participants, HBV reverse transcriptase (RT)/surface (S) sequences were analyzed for drug resistance, immuneescape mutants, and phylogeny. Results: Overall, 78.3% (166/212) participants had past/ongoing HBV-exposure, with 39.1% (83/212) carrying “HBcAbpositive alone”. Prevalence of overt HBV (positive-HBsAg) was 11.8% (25/212), prevalence of HBV and HDV was respectively 6.9% (12/175) and 12% (3/25). Phylogeny of HBV-RT/S revealed the co-circulation of genotypes A and E. All HBV-coinfected participants harbored HBV strains with at least one immune-escape mutation. Of note, one HBV variant carried the vaccine-escape mutation G145R that hinders HBsAg neutralization by antibodies. For the first time, a novel 9 aa-deletion (s115-s123), located in the HBsAg “a” determinant, was found concomitantly with OBI. A stop codon in the S region (associated with increased risk of hepatocellular carcinoma) was found in six cases. Conclusion: High prevalence of overt/occult HBV-infection and circulating atypical strains highlight the importance of HBV-surveillance among HIV-infected Cameroonians and strategies to detect OBI in highly endemic countries.
- Subjects :
- Adult
Male
0301 basic medicine
Hepatitis B virus
HBsAg
HIV-infected Cameroonians
Genotype
HIV Infections
Drug resistance
medicine.disease_cause
Virus
Young Adult
03 medical and health sciences
Virology
Prevalence
medicine
Humans
Cameroon
Hepatitis B Antibodies
HDV co-infection
Hepatitis B virus, occult Hepatitis B, drug resistance, genotyping, immune escape, HDV co-infection, HIV-infected Cameroonians
Hepatitis
Hepatitis B Surface Antigens
drug resistance
Coinfection
business.industry
immune escape
virus diseases
Middle Aged
Hepatitis B
Settore MED/07 - Microbiologia e Microbiologia Clinica
medicine.disease
030112 virology
digestive system diseases
occult Hepatitis B
Infectious Diseases
genotyping
DNA, Viral
Immunology
Female
Liver function
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....a72842f90b2db1513b6d73774d03a76a