304 results on '"Lanoy E"'
Search Results
2. Persistence of anal squamous intraepithelial lesions and anal HPV infection in HIV-infected patientsdespite immune restoration under cART
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Tartour E, Abramowitz L, Tubiana R, Girard P-M, Trabelsi S, Cochand-Priolet B, Si-Mohamed A, Lanoy E, Piketty C, Rouzioux C, Weiss L, and Costagliola D
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Infectious and parasitic diseases ,RC109-216 - Published
- 2010
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3. Epidemiology of non-keratinocytic skin cancers among persons with AIDS in the United States
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Toro JR, Madeleine MM, Dores GM, Lanoy E, Fraumeni JF, and Engels EA
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Infectious and parasitic diseases ,RC109-216 - Published
- 2009
- Full Text
- View/download PDF
4. Acide tranexamique pour le traitement de l’hémoptysie, étude en vie réelle–ATHENE
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Gaffier, M., primary, Beaudoin, A., additional, Lanoy, E., additional, Rothstein, V., additional, Hamdan, A., additional, Soumagne, T., additional, Sanchez, O., additional, and Planquette, B., additional
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- 2024
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5. MSR145 Identifying Effect of a Treatment from Observational Data in Absence of Contemporaneous Control: Example of the French Study Tosca, Comparing Cemiplimab Vs. Historical Systemic Treatment in Cutaneous Squamous Cell Carcinoma
- Author
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Perrier, S., primary, Vataire, A.L., additional, Garnier, S., additional, Tabellion, A., additional, and Lanoy, E., additional
- Published
- 2023
- Full Text
- View/download PDF
6. Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab
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Chaput, N., Lepage, P., Coutzac, C., Soularue, E., Le Roux, K., Monot, C., Boselli, L., Routier, E., Cassard, L., Collins, M., Vaysse, T., Marthey, L., Eggermont, A., Asvatourian, V., Lanoy, E., Mateus, C., Robert, C., and Carbonnel, F.
- Published
- 2017
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- View/download PDF
7. Challenges of phase 1 clinical trials evaluating immune checkpoint-targeted antibodies
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Postel-Vinay, S., Aspeslagh, S., Lanoy, E., Robert, C., Soria, J.-C., and Marabelle, A.
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- 2016
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8. Aircraft noise effect on self-reported health through noise annoyance: causal mediation analysis in the DEBATS longitudinal study in France
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Kodji, M.K., primary, Lanoy, E., additional, Giorgis Allemand, L., additional, and Evrard, A.-S., additional
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- 2022
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9. Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease
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Marthey, L., Mateus, C., Mussini, C., Nachury, M., Nancey, S., Grange, F., Zallot, C., Peyrin-Biroulet, L., Rahier, J. F., Bourdier de Beauregard, M., Mortier, L., Coutzac, C., Soularue, E., Lanoy, E., Kapel, N., Planchard, D., Chaput, N., Robert, C., and Carbonnel, F.
- Published
- 2016
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- View/download PDF
10. Cémiplimab versus traitements systémiques historiques du carcinome épidermoïde cutané localement avancé ou métastatique : résultats de l’étude TOSCA
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Gerard, E., Lebbé, C., Lanoy, E., Quéreux, G., Bernard, P., Viguier, M., Meyer, N., Mortier, L., Dinulescu, M., Legoupil, D., Neidhardt, E.M., Saiag, P., Trabelsi, S., Célérier, P., Nardin, C., Maubec, E., Duval-Modeste, A.B., Hainault, E., Darras, S., Maillard, H., Guégan, S., Arnault, J.P., Stoebner, P.E., Le Corre, Y., Grange, F., Peuvrel, L., Bonniaud, B., Herrscher, H., Granel-Brocard, F., Vataire, A.L., Perrier, S., Tabellion, A., Garnier, S., and Robert, C.
- Published
- 2023
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11. 1140P Cemiplimab versus historical systemic treatments for locally advanced (la) or metastatic (m) cutaneous squamous cell carcinomas (CSCC): Results from the French study TOSCA
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Gerard, E., Lebbe, C., Lanoy, E., Quereux, G., Bernard, P., Viguier, M-A., Meyer, N., Mortier, L., Dinulescu, M., Legoupil, D., Neidhardt, E.M., Saiag, P., Trabelsi-Messai, S., Celerier, P., Nardin, C., Maubec, E., Hainaut Wierzbicka, E., Perrier, S., Garnier, S., and Robert, C.
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- 2023
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12. Therapeutic Management of Advanced Adrenocortical Carcinoma: What Do We Know in 2011?
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Baudin, E., Leboulleux, S., Al Ghuzlan, A., Chougnet, C., Young, J., Deandreis, D., Dumont, F., Dechamps, F., Caramella, C., Chanson, P., Lanoy, E., Borget, I., and Schlumberger, M.
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- 2011
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13. Évaluation de différentes stratégies d’analyse pour préserver la puissance dans les essais randomisés en immuno-oncologie
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Boher, J., primary, Filleron, T., additional, Lanoy, E., additional, and Cook, R., additional
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- 2021
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14. Estimation de la fréquence des atteintes plantaires à dermatophytes: Étude rétrospective 2002-2003
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Foulet, F., Cremer, G., Bourdon-Lanoy, E., Wolkenstein, P., Chosidow, O., Bretagne, S., and Revuz, J.
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- 2007
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15. Demandes de rendez-vous en urgence en dermatologie libérale : ETude Urgences en DErmatologie libérale (ET.U.DE)
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Penso-Assathiany, D., Bourdon-Lanoy, E., Derancourt, C., Roujeau, J.-C., and Bastuji-Garin, S.
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- 2007
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16. 22P Toxicity profile of immune and non-immune therapies in phase I/II trials: A comprehensive longitudinal analysis
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Missri, L., primary, Martin-Romano, P., additional, Helissey, C., additional, Lanoy, E., additional, Baldini, C., additional, Varga, A., additional, Hollebecque, A., additional, Michot, J-M., additional, Gazzah, A., additional, Bahleda, R., additional, Champiat, S., additional, Italiano, A., additional, Ribrag, V., additional, Angevin, E., additional, Armand, J-P., additional, Deutsch, E., additional, Marabelle, A., additional, Soria, J-C., additional, Massard, C., additional, and Postel-Vinay, S., additional
- Published
- 2021
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17. Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival
- Author
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Delyon, J., Mateus, C., Lefeuvre, D., Lanoy, E., Zitvogel, L., Chaput, N., Roy, S., Eggermont, A. M. M., Routier, E., and Robert, C.
- Published
- 2013
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18. Factors influencing quality of life in patients with inherited ichthyosis: a qualitative study in adults using focus groups
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Mazereeuw-Hautier, J., Dreyfus, I., Barbarot, S., Serrentino, L., Bourdon-Lanoy, E., Ezzedine, K., Maza, A., Aujoulat, I., and Le Rhun, A.
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- 2012
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19. Short- and medium-term efficacy of specific hydrotherapy in inherited ichthyosis
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Bodemer, C., Bourrat, E., Mazereeuw-Hautier, J., Boralevi, F., Barbarot, S., Bessis, D., Blanchet-Bardon, C., Bourdon-Lanoy, E., Stalder, J.-F., Ribet, V., Guerrero, D., and Sibaud, V.
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- 2011
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20. Comparative effectiveness of continuing a virologically effective first-line boosted protease inhibitor combination or of switching to a three-drug regimen containing either efavirenz, nevirapine or abacavir
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Bommenel, T., Launay, O., Meynard, J. L., Gilquin, J., Katlama, C., Lascaux, A. S., Mahamat, A., Martinez, V., Pradier, C., Rouveix, E., Simon, A., Costagliola, D., Abgrall, S., Abgrall, S., Barin, F., Bentata, M., Billaud, E., Boué, F., Burty, C., Cabié, A., Costagliola, D., Cotte, L., de Truchis, P., Duval, X., Duvivier, C., Enel, P., Gasnault, J., Gaud, C., Gilquin, J., Grabar, S., Katlama, C., Khuong, M. A., Lang, J. M., Lascaux, A. S., Launay, O., Mahamat, A., Mary-Krause, M., Matheron, S., Meynard, J. L., Pavie, J., Pialoux, G., Pilorgé, F., Poizot-Martin, I., Pradier, C., Reynes, J., Rouveix, E., Simon, A., Tattevin, P., Tissot-Dupont, H., Viard, J. P., Viget, N., Brosseau, M., Salomon, V., Jacquemet, N., Guiguet, M., Lanoy, E., Lièvre, L., Selinger-Leneman, H., Lacombe, J. M., Potard, V., Bricaire, F., Herson, S., Desplanque, N., Girard, P. M., Meyohas, M. C., Picard, O., Cadranel, J., Mayaud, C., Clauvel, J. P., Decazes, J. M., Gerard, L., Molina, J. M., Diemer, M., Sellier, P., Honoré, P., Jeantils, V., Tassi, S., Mechali, D., Taverne, B., Bouvet, E., Crickx, B., Ecobichon, J. L., Picard-Dahan, C., Yeni, P., Berthé, H., Dupont, C., Chandemerle, C., Mortier, E., Tisne-Dessus, D., Weiss, L., Salmon, D., Auperin, I., Roudière, L., Fior, R., Delfraissy, J. F., Goujard, C., Jung, C., Lesprit, P., Vittecoq, D., Fraisse, P., Rey, D., Beck-Wirth, G., Stahl, J. P., Lecercq, P., Gourdon, F., Laurichesse, H., Fresard, A., Lucht, F., Bazin, C., Verdon, R., Chavanet, P., Arvieux, C., Michelet, C., Choutet, P., Goudeau, A., Maître, M. F., Hoen, B., Elinger, P., Faller, J. P., Borsa-Lebas, F., Caron, F., Daurès, J. P., May, T., Rabaud, C., Berger, J. L., Rémy, G., Arlet-Suau, E., Cuzin, L., Massip, P., Thiercelin Legrand, M. F., Pontonnier, G., Yasdanpanah, Y., Dellamonica, P., Pugliese, P., Aleksandrowicz, K., Quinsat, D., Ravaux, I., Delmont, J. P., Moreau, J., Gastaut, J. A., Retornaz, F., Soubeyrand, J., Galinier, A., Ruiz, J. M., Allegre, T., Blanc, P. A., Bonnet-Montchardon, D., Lepeu, G., Granet-Brunello, P., Esterni, J. P., Pelissier, L., Cohen-Valensi, R., Nezri, M., Chapadaud, S., Laffeuillade, A., Raffi, F., Boibieux, A., Peyramond, D., Livrozet, J. M., Touraine, J. L., Trepo, C., Strobel, M., Bissuel, F., Pradinaud, R., Sobesky, M., and Contant, M.
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- 2011
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21. PO-1227: A dose escalation phase 1 study of radiotherapy combined with ipilimumab in metastatic melanoma.
- Author
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Boutros, C., primary, Chaput, N., additional, Lanoy, E., additional, Larive, A., additional, Mateus, C., additional, Routier, E., additional, Roy, S., additional, Sun, R., additional, Lancia, A., additional, Tao, Y.G., additional, Ibrahim, N., additional, Khoury-Abboud, R., additional, Massard, C., additional, Bahleda, R., additional, Schwob, D., additional, Caramella, C., additional, Cassard, L., additional, Soria, J., additional, Robert, C., additional, and Deutsch, E., additional
- Published
- 2020
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22. Early skin biopsy is helpful for the diagnosis and management of neonatal and infantile erythrodermas
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Leclerc-Mercier, S., Bodemer, C., Bourdon-Lanoy, E., Larousserie, F., Hovnanian, A., Brousse, N., and Fraitag, S.
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- 2010
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23. Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replication
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Boccara, O., Lesage, F., Regnault, V., Lasne, D., Dupic, L., Bourdon-Lanoy, E., Pannier, S., Fraitag, S., Audat, F., Lecompte, T., Hubert, P., and Bodemer, C.
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- 2009
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24. How does loss to follow-up influence cohort findings on HIV infection? A joint analysis of the French hospital database on HIV, Mortalité 2000 survey and death certificates
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Lanoy, E, Lewden, C, Lièvre, L, Tattevin, P, Boileau, J, Aouba, A, Chêne, G, and Costagliola, D
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- 2009
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25. Recovery of fat following a switch to nucleoside reverse transcriptase inhibitor-sparing therapy in patients with lipoatrophy: results from the 96-week randomized ANRS 108 NoNuke Trial
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Valantin, M A, Lanoy, E, Bentata, M, Kalmykova, O, Boutekadjirt, A, Allavena, C, Rozenbaum, W, Peytavin, G, Amellal, B, Calvez, V, Costagliola, D, and Katlama, C
- Published
- 2008
26. Causes of the first AIDS-defining illness and subsequent survival before and after the advent of combined antiretroviral therapy
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Grabar, S, Lanoy, E, Allavena, C, Mary-Krause, M, Bentata, M, Fischer, P, Mahamat, A, Rabaud, C, and Costagliola, D
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- 2008
27. Awareness, knowledge and attitudes towards sun protection among skin cancer-treated patients in France
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Meyer, N, Pruvost-Balland, C, Bourdon-Lanoy, E, Maubec, E, and Avri, M-F
- Published
- 2007
28. Poor agreement between self-reported and dermatologistsʼ diagnoses for five common dermatoses
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Jagou, M., Bastuji-Garin, S., Bourdon-Lanoy, E., Penso-Assathiany, D., and Roujeau, J-C.
- Published
- 2006
29. Genetic Study of Netherton Syndrome in a Large International Cohort
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Deraison, C, Descargues, P, Lacaze-Buzy, L, Besson, C, Mazarguil, A M, Mazereeuw-Hautier, J, Bourdon-Lanoy, E, de Prost, Y, Bodemer, C, and Hovnanian, A
- Published
- 2006
30. Viral rebound on antiretroviral therapy in France according to region of origin, sex, and HIV acquisition group. Results from the French Hospital Database on HIV (ANRS CO4‐FHDH)
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Abgrall, S., Selinger‐Leneman, H., Lanoy, E., Becker, A., Matheron, S., Truchis, P., Pavie, J., Canestri, A., Khuong, M. A., Rey, D., Caby, F., Tattevin, P., Palich, R., and Grabar, S.
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MEN who have sex with men , *HETEROSEXUAL men , *ANTIRETROVIRAL agents , *DATABASES , *CONFIDENCE intervals - Abstract
Background Methods Results Conclusions Assessing the potential increased risk of viral rebound (VR) in migrants requires adequate control for sex and acquisition risk groups.People living with HIV1, enrolled in the ANRS CO4‐French Hospital Database on HIV, who achieved virological suppression with antiretroviral therapy (ART) initiated between 2006 and 2016 were included. We first compared the risk of VR, with loss to follow‐up and death considered as competing events, across origin among the HIV acquisition groups, then across acquisition groups among the different origins, and finally across modality of a variable combining sex, acquisition group, and origin. Models were adjusted for clinical and biological confounding factors.We included 21 571 French natives (FRA), 10 148 migrants from sub‐Saharan Africa (SSA), 1137 migrants from the non‐French West Indies (NFWI), and 4205 other migrants (OTHER). The 5‐year probability of VR was 19% (95% confidence interval [CI] 19–20) overall, 15% in FRA, 21% in OTHER, 26% in SSA, and 34% in NFWI (p < 0.0001). It was 14% in men who have sex with men (MSM), 23% in heterosexual men, and 23% in women (p < 0.0001). After adjustment, all acquisition groups had a higher risk of VR than MSM from FRA, with men and women from NFWI having the highest risk (adjusted hazard ratio [aHR] 2.46; 95% CI 2.12–2.86 and aHR 2.59; 95% CI 2.20–3.04, respectively). Within each acquisition group, all groups of origin had a higher risk of VR than FRA. Within each region of origin, except the NFWI, heterosexual men had a higher risk of VR than MSM.After accounting for sex and acquisition group, migration, especially from NFWI, remains prognostic of VR. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab
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Chaput, N., primary, Lepage, P., additional, Coutzac, C., additional, Soularue, E., additional, Le Roux, K., additional, Monot, C., additional, Boselli, L., additional, Routier, E., additional, Cassard, L., additional, Collins, M., additional, Vaysse, T., additional, Marthey, L., additional, Eggermont, A., additional, Asvatourian, V., additional, Lanoy, E., additional, Mateus, C., additional, Robert, C., additional, and Carbonnel, F., additional
- Published
- 2019
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32. Ancillary evaluation of systemic immune antitumour response (SIAR) and tumour growth rate (TGR) of patients (pts) with metastatic melanoma (MM) treated with radiotherapy (RT) combined with ipilimumab (ipi) in the phase I study Mel-Ipi-Rx
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Boutros, C., primary, Chaput, N., additional, Lanoy, E., additional, Larive, A., additional, Mateus, C., additional, Routier, E., additional, Roy, S., additional, Sun, R., additional, Lancia, A., additional, Tao, Y., additional, Ibrahim, N., additional, Khoury-Abboud, R.M., additional, Massard, C., additional, Bahleda, R., additional, Schwob, D., additional, Caramella, C., additional, Cassard, L., additional, Soria, J.-C., additional, Robert, C., additional, and Deutsch, E., additional
- Published
- 2019
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33. Fresh blood Immune cell monitoring in patients treated with nivolumab in the GETUG-AFU26 NIVOREN study: Association with toxicity and treatment outcome
- Author
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Desnoyer, A., primary, Larive, A., additional, Drubay, D., additional, Lanoy, E., additional, Vano, Y., additional, Rioux-Leclercq, N., additional, Chouaib, S., additional, Beuselinck, B., additional, Tantot, F., additional, Escudier, B., additional, Chaput, N., additional, and Albiges, L., additional
- Published
- 2019
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34. Présentation inhabituelle d’une sarcoïdose de l’enfant
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Bourdon-Lanoy, E., Abou Taam, R., Cavailhes, A., Hadj-Rabia, S., Hamel, D., De Prost, Y., and Bodemer, C.
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- 2007
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35. Pseudo purpura fulminans et primo-infection à HHV6
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Boccara-Perrin, O., Lesage, F., Lasne, D., Dupic, L., Bourdon-Lanoy, E., Fraitag, S., Boulat, C., Audat, F., Hubert, P., and Bodemer, C.
- Published
- 2007
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36. Syndrome PHACES : fréquence des malformations associées, origine vasculaire de l’atteinte cérébrale. Étude de 15 cas
- Author
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Piram, M., Boddaert, N., Brunelle, F., Parsy, C., Hadj-Rabia, S., Bourdon-Lanoy, E., Bodemer, C., De Prost, Y., and Hamel, D.
- Published
- 2007
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37. Répondeurs complets sous immunothérapie et thérapie ciblée dans le mélanome avancé
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Vallet, A., primary, Routier, E., additional, Reigneau, M., additional, Fahmy, J., additional, Ghoufi, L., additional, Libenciuc, C., additional, Lanoy, E., additional, Allorant, A., additional, Mateus, C., additional, and Robert, C., additional
- Published
- 2017
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38. Tolérance et efficacité des anticorps anti immune check-point inhibiteurs (anti PD-1/PD-L1) chez les patients atteints d’une maladie auto-immune ou inflammatoire
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Danlos, F.X., primary, Voisin, A.L., additional, Dyevre, V., additional, Michot, J.M., additional, Routier, E., additional, Champiat, S., additional, Massard, C., additional, Besse, B., additional, Mateus, C., additional, Lanoy, E., additional, Marabelle, A., additional, and Lambotte, O., additional
- Published
- 2017
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39. Tolerance and outcomes of stereotactic radiosurgery combined with anti-PD1 (pembrolizumab) for melanoma brain metastases
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Nardin, C., primary, Mateus, C., additional, Texier, M., additional, Lanoy, E., additional, Hibat-Allah, S., additional, Ammari, S., additional, Robert, C., additional, and Dhermain, F., additional
- Published
- 2017
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40. Baseline gut microbiota in metastatic melanoma patients treated with ipilimumab: Relation with clinical response and colitis
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Chaput, N., primary, Lepage, P., additional, Coutzac, C., additional, Soularue, E., additional, Asvatourian, V., additional, Lanoy, E., additional, Mateus, C., additional, Carbonnel, F., additional, and Robert, C., additional
- Published
- 2017
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41. Long term survival in patients responding to an Anti-PD-1/PD-L1 therapy and disease outcome upon treatment discontinuation
- Author
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Gauci, M-L., primary, Lanoy, E., additional, Champiat, S., additional, Michot, J-M., additional, Varga, A., additional, Bahleda, R., additional, Angevin, E., additional, Gazzah, A., additional, Verlingue, L., additional, Bigot, F., additional, Aspeslagh, S., additional, Castanon, E., additional, Baldini, C., additional, Postel-Vinay, S., additional, Massard, C., additional, Hollebecque, A., additional, Soria, J-C., additional, and Marabelle, A., additional
- Published
- 2017
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42. Outil de RElance et Suivi des DOnnées Cliniques (ORESDOC)
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Mangin, A., primary, Cheurfa, N., additional, Angokai, M., additional, Jan, P., additional, Maalem, S., additional, Lanoy, E., additional, Schwob, D., additional, and Goma, G., additional
- Published
- 2017
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43. Extension des « missingness graphs » à des mesures répétées de biomarqueurs
- Author
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Asvatourian, V., primary, Michiels, S., additional, and Lanoy, E., additional
- Published
- 2017
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44. Prediction of Waitlist Mortality in Adult Heart Transplant Candidates: The Candidate Risk Score
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Jasseron, C., primary, Legeai, C., additional, Jacquelinet, C., additional, Leprince, P., additional, Cantrelle, C., additional, Audry, B., additional, Lanoy, E., additional, Porcher, R., additional, Bastien, O., additional, and Dorent, R., additional
- Published
- 2017
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45. Enterocolitis in Patients With Cancer After Antibody Blockade of Cytotoxic T-Lymphocyte–Associated Antigen 4
- Author
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Illouz, Frédéric, Wang, Daniel Y, Ye, Fei, Zhao, Shilin, Johnson, Douglas B, Gupta, A., De Felice, K. M., Loftus, E. V., Khanna, S., Beck, Kimberly E., Blansfield, Joseph A., Tran, Khoi Q., Feldman, Andrew L., Hughes, Marybeth S., Royal, Richard E., Kammula, Udai S., Topalian, Suzanne L., Sherry, Richard M., Kleiner, David, Quezado, Martha, Lowy, Israel, Yellin, Michael, Rosenberg, Steven A., Yang, James C., Michot, J. M., Bigenwald, C., Champiat, S., Collins, M., Carbonnel, Franck, Postel-Vinay, S., Berdelou, A., Varga, A., Bahleda, R., Hollebecque, A., Massard, C., Fuerea, A., Ribrag, V., Gazzah, A., Armand, J. P., Amellal, N., Angevin, E., Noel, N., Boutros, C., Mateus, C., Robert, C., Soria, J. C., Marabelle, A., Lambotte, O., Gonzalez, Raul S., Salaria, Safia N., Bohannon, Caitlin D., Huber, Aaron R., Feely, Michael M., Shi, Chanjuan, Marthey, L., Mussini, C., Nachury, M., Nancey, S., Grange, F., Zallot, C., Peyrin-Biroulet, L., Rahier, J. F., de Beauregard, M. Bourdier, Mortier, L., Coutzac, C., Soularue, E., Lanoy, E., Kapel, N., Planchard, D., Chaput, N., Benson, Al B., Ajani, Jaffer A., Catalano, Robert B., Engelking, Constance, Kornblau, Steven M., Martenson, James A., McCallum, Richard, Mitchell, Edith P., O'Dorisio, Thomas M., Vokes, Everett E., Wadler, Scott, Haanen, J B A G, Kerr, K M, Peters, S, Larkin, J, Jordan, K, Bergqvist, Viktoria, Hertervig, Erik, Gedeon, Peter, Kopljar, Marija, Griph, Håkan, Kinhult, Sara, Carneiro, Ana, Marsal, Jan, Hsieh, Amy Hsin Chieh, Ferman, Mutaz, Brown, Michael P., Andrews, Jane M., Trainer, Harris, Hulse, Paul, Higham, Claire E, Trainer, Peter, Lorigan, Paul, Hughes, Jing, Vudattu, Nalini, Sznol, Mario, Gettinger, Scott, Kluger, Harriet, Lupsa, Beatrice, and Herold, Kevan C
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Male ,Skin Neoplasms ,Cytotoxic ,medicine.medical_treatment ,Autoimmunity ,Dermatitis ,Lymphocyte Activation ,Gastroenterology ,Immune-related adverse events ,T-Lymphocyte Subsets ,Adrenal Cortex Hormones ,80 and over ,Immune-checkpoint inhibitor induced enterocolitis ,Neoplasm Metastasis ,Melanoma ,Enterocolitis ,Membrane Glycoproteins ,Subcutaneous ,Vaccination ,Antibodies, Monoclonal ,programmed cell death protein 1 ,Kidney Neoplasms ,Neoplasm Proteins ,Oncology ,Disease Progression ,chemically induced ,Lung cancer ,Nivolumab ,gastroenteritis ,Type 1 ,medicine.medical_specialty ,Antineoplastic Agents ,chemistry ,Antigen ,Antigens, CD ,HLA-A2 Antigen ,Diabetes Mellitus ,Humans ,Tumour neoantigen ,Aged ,ResearchInstitutes_Networks_Beacons/mcrc ,Immunotherapy ,medicine.disease ,Peptide Fragments ,Immunology ,adverse effects ,gastrointestinal tract ,Peptides ,Immune checkpoint blockade ,Autoimmune ,Cancer Research ,colitis ,T-Lymphocytes ,Programmed Cell Death 1 Receptor ,administration & dosage ,Anti-CTLA-4 ,Hepatitis ,immunology ,Neoplasms ,Monoclonal ,CTLA-4 Antigen ,Manchester Cancer Research Centre ,Anti-PD-1 antibody ,Cytotoxic T-lymphocyte-associated antigen 4 ,Middle Aged ,CD ,Differentiation ,Female ,immunotherapy ,medicine.symptom ,Intravenous ,gp100 Melanoma Antigen ,medicine.drug ,Adult ,etiology ,Vitiligo ,chemical and pharmacologic phenomena ,Ipilimumab ,Cancer Vaccines ,Antibodies ,Autoimmune Diseases ,Injections ,Gastrointestinal Agents ,blood ,Internal medicine ,Immune Tolerance ,medicine ,Antigens ,Vedolizumab treatment against irAEs ,Carcinoma, Renal Cell ,Salvage Therapy ,therapy ,business.industry ,Cancer ,Antigens, Differentiation ,Infliximab ,therapeutic use ,physiology ,Neoplasm ,pathology ,business - Abstract
PurposeCytotoxic T-lymphocyte–associated antigen 4 (CTLA4) is an inhibitory receptor on T cells. Knocking out CTLA4 in mice causes lethal lymphoproliferation, and polymorphisms in human CTLA4 are associated with autoimmune disease. Trials of the anti-CTLA4 antibody ipilimumab (MDX-010) have resulted in durable cancer regression and immune-mediated toxicities. A report on the diagnosis, pathology, treatment, clinical outcome, and significance of the immune-mediated enterocolitis seen with ipilimumab is presented.Patients and MethodsWe treated 198 patients with metastatic melanoma (MM) or renal cell carcinoma (RCC) with ipilimumab.ResultsThe overall objective tumor response rate was 14%. We observed several immune mediated toxicities including dermatitis, enterocolitis, hypophysitis, uveitis, hepatitis, and nephritis. Enterocolitis, defined by grade 3/4 clinical presentation and/or biopsy documentation, was the most common major toxicity (21% of patients). It presented with diarrhea, and biopsies showed both neutrophilic and lymphocytic inflammation. Most patients who developed enterocolitis responded to high-dose systemic corticosteroids. There was no evidence that steroid administration affected tumor responses. Five patients developed perforation or required colectomy. Four other patients with steroid-refractory enterocolitis appeared to respond promptly to tumor necrosis factor alpha blockade with infliximab. Objective tumor response rates in patients with enterocolitis were 36% for MM and 35% for RCC, compared with 11% and 2% in patients without enterocolitis, respectively (P = .0065 for MM and P = .0016 for RCC).ConclusionCTLA4 seems to be a significant component of tolerance to tumor and in protection against immune mediated enterocolitis and these phenomena are significantly associated in cancer patients.
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- 2006
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46. 1368P - Ancillary evaluation of systemic immune antitumour response (SIAR) and tumour growth rate (TGR) of patients (pts) with metastatic melanoma (MM) treated with radiotherapy (RT) combined with ipilimumab (ipi) in the phase I study Mel-Ipi-Rx
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Boutros, C., Chaput, N., Lanoy, E., Larive, A., Mateus, C., Routier, E., Roy, S., Sun, R., Lancia, A., Tao, Y., Ibrahim, N., Khoury-Abboud, R.M., Massard, C., Bahleda, R., Schwob, D., Caramella, C., Cassard, L., Soria, J.-C., Robert, C., and Deutsch, E.
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- 2019
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47. 972P - Fresh blood Immune cell monitoring in patients treated with nivolumab in the GETUG-AFU26 NIVOREN study: Association with toxicity and treatment outcome
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Desnoyer, A., Larive, A., Drubay, D., Lanoy, E., Vano, Y., Rioux-Leclercq, N., Chouaib, S., Beuselinck, B., Tantot, F., Escudier, B., Chaput, N., and Albiges, L.
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- 2019
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48. Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy : not all AIDS-defining conditions are created equal
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Antiretroviral Therapy Cohort Collaboration Mocroft A, Sterne JA, Egger M, May M, Grabar S, Furrer H, Sabin C, Fatkenheuer G, Justice A, Reiss P, d'Arminio Monforte A, Gill J, Hogg R, Bonnet F, Kitahata M, Staszewski S, Casabona J, Harris R, Saag M, Chêne G, Costagliola D, Dabis F, D'Arminio Monforte A, de Wolf F, Ledergerber B, Mocroft A, Phillips A, Weller I, Sterne J, Abgrall S, Barin F, Bentata M, Billaud E, Boué F, Burty C, Cabié A, Cotte L, De Truchis P, Duval X, Duvivier C, Enel P, Fredouille Heripret L, Gasnault J, Gaud C, Gilquin J, Katlama C, Khuong MA, Lang JM, Lascaux AS, Launay O, Mahamat A, Mary Krause M, Matheron S, Meynard JL, Pavie J, Pialoux G, Pilorgé F, Poizot Martin I, Pradier C, Reynes J, Rouveix E, Simon A, Tattevin P, Tissot Dupont H, Viard JP, Viget N, Pariente Khayat A, Salomon V, Jacquemet N, Rivet A, Guiguet M, Kousignian I, Lanoy E, Lièvre L, Potard V, Selinger Leneman H, Bouvet E, Crickx B, Ecobichon JL, Leport C, Picard Dahan C, Yeni P, Tisne Dessus D, Weiss L, Salmon D, Sicard D, Auperin I, Roudière L, Fior R, Delfraissy JF, Goujard C, Jung C, Lesprit P, Desplanque N, Meyohas MC, Picard O, Cadranel J, Mayaud C, Bricaire F, Herson S, Clauvel JP, Decazes JM, Gerard L, Molina JM, Diemer M, Sellier P, Berthé H, Dupont C, Chandemerle C, Mortier E, Honoré P, Jeantils V, Tassi S, Mechali D, Taverne B, Gourdon F, Laurichesse H, Fresard A, Lucht F, Eglinger P, Faller JP, Bazin C, Verdon R, Boibieux A, Peyramond D, Livrozet JM, Touraine JL, Trepo C, Ravaux I, Delmont JP, Moreau J, Gastaut JA, Retornaz F, Soubeyrand J, Allegre T, Blanc PA, Galinier A, Ruiz JM, Lepeu G, Granet Brunello P, Esterni JP, Pelissier L, Cohen Valensi R, Nezri M, Chadapaud S, Laffeuillade A, May T, Rabaud C, Raffi F, Arvieux C, Michelet C, Borsa Lebas F, Caron F, Fraisse P, Rey D, Arlet Suau E, Cuzin L, Massip P, Thiercelin Legrand MF, Yasdanpanah Y, Pradinaud R, Sobesky M, Contant M, Montroni M, Scalise G, Braschi MC, Riva A, Tirelli U, Martellotta F, Pastore G, Ladisa N, Suter F, Arici C, Chiodo F, Colangeli V, Fiorini C, Carosi G, Cristini G, Torti C, Minardi C, Bertelli D, Quirino T, Manconi PE, Piano P, Cosco L, Scerbo A, Vecchiet J, D'Alessandro M, Santoro D, Pusterla L, Carnevale G, Lorenzotti S, Viganò P, Mena M, Ghinelli F, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Lo Caputo S, Grisorio B, Ferrara S, Grima P, Grima PF, Pagano G, Cassola G, Alessandrini A, Piscopo R, Toti M, Trezzi M, Soscia F, Tacconi L, Orani A, Perini P, Scasso A, Vincenti A, Chiodera F, Castelli P, Scalzini A, Palvarini L, Moroni M, Lazzarin A, Rizzardini G, Caggese L, Cicconi P, Galli A, Merli S, Pastecchia C, Moioli MC, Esposito R, Mussini C, Abrescia N, Chirianni A, Izzo CM, Piazza M, De Marco M, Viglietti R, Manzillo E, Colomba A, Abbadessa V, Prestileo T, Mancuso S, Ferrari C, Pizzaferri P, Filice G, Minoli L, Bruno R, Novati S, Baldelli F, Camanni G, Petrelli E, Cioppi A, Alberici F, Ruggieri A, Menichetti F, Martinelli C, De Stefano C, La Gala A, Ballardini G, Rizzo E, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda R, Dianzani F, Ippolito G, Antinori A, Antonucci G, Ciardi M, Narciso P, Petrosillo N, Vullo V, De Luca A, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Noto P, Lichtner M, Capobianchi MR, Carletti F, Girardi E, Pezzotti P, Rezza G, Mura MS, Mannazzu M, Caramello P, Di Perri G, Orofino GC, Sciandra M, Grossi PA, Basilico C, Poggio A, Bottari G, Raise E, Ebo F, Pellizzer G, Buonfrate D, Resta F, Loso K, Cozzi Lepri A, Battegay M, Bernasconi E, Böni J, Bucher H, Bürgisser P, Cattacin S, Cavassini M, Dubs R, Elzi L, Erb P, Fischer M, Flepp M, Fontana A, Francioli P, Gorgievski M, Günthard H, Hirsch H, Hirschel B, Hösli I, Kahlert C, Kaiser L, Karrer U, Kind C, Klimkait T, Martinetti G, Martinez B, Müller N, Nadal D, Opravil M, Paccaud F, Pantaleo G, Rickenbach M, Rudin C, Schmid P, Schultze D, Schüpbach J, Speck R, Taffé P, Tarr P, Telenti A, Trkola A, Vernazza P, Weber R, Yerly S, Gras LA, van Sighem AI, Smit C, Bronsveld W, Hillebrand Haverkort ME, Prins JM, Branger J, Eeftinck Schattenkerk JK, Gisolf J, Godfried MH, Lange JM, Lettinga KD, van der Meer JT, Nellen FJ, van der Poll T, Ruys TA, Steingrover R, Vermeulen JN, Vrouenraets SM, van Vugt M, Wit FW, Kuijpers TW, Pajkrt D, Scherpbier HJ, van Eeden A, Brinkman K, van den Berk GE, Blok WL, Frissen PH, Roos JC, Schouten WE, Mulder JW, van Gorp EC, Wagenaar J, Veenstra J, Danner SA, Van Agtmael MA, Claessen FA, Perenboom RM, Rijkeboer A, van Vonderen MG, Richter C, van der Berg J, Vriesendorp R, Jeurissen FJ, Kauffmann RH, Pogány K, Bravenboer B, ten Napel CH, Kootstra GJ, Sprenger HG, van Assen S, van Leeuwen JT, Doedens R, Scholvinck EH, ten Kate RW, Soetekouw R, van Houte D, Polée MB, Kroon FP, van den Broek PJ, van Dissel JT, Schippers EF, Schreij G, van der Geest S, Lowe S, Verbon A, Koopmans PP, Van Crevel R, de Groot R, Keuter M, Post F, van der Ven AJ, Warris A, van der Ende ME, Gyssens IC, van der Feltz M, Nouwen JL, Rijnders BJ, de Vries TE, Driessen G, van der Flier M, Hartwig NG, Juttman JR, van Kasteren ME, Van de Heul C, Hoepelman IM, Schneider MM, Bonten MJ, Borleffs JC, Ellerbroek PM, Jaspers CA, Mudrikove T, Schurink CA, Gisolf EH, Geelen SP, Wolfs TF, Faber T, Tanis AA, Groeneveld PH, den Hollander JG, Duits AJ, Winkel K, Back NK, Bakker ME, Berkhout B, Jurriaans S, Zaaijer HL, Cuijpers T, Rietra PJ, Roozendaal KJ, Pauw W, van Zanten AP, Smits PH, von Blomberg BM, Savelkoul P, Pettersson A, Swanink CM, Franck PF, Lampe AS, Jansen CL, Hendriks R, Benne CA, Veenendaal D, Storm H, Weel J, van Zeijl JH, Kroes AC, Claas HC, Bruggeman CA, Goossens VJ, Galama JM, Melchers WJ, Poort YA, Doornum GJ, Niesters MG, Osterhaus AD, Schutten M, Buiting AG, Swaans CA, Boucher CA, Schuurman R, Boel E, Jansz AF, Veldkamp A, Beijnen JH, Huitema AD, Burger DM, Hugen PW, van Kan HJ, Losso M, Duran A, Vetter N, Karpov I, Vassilenko A, Mitsura VM, Suetnov O, Clumeck N, De Wit S, Poll B, Colebunders R, Kostov K, Begovac J, Machala L, Rozsypal H, Sedlacek D, Nielsen J, Lundgren J, Benfield T, Kirk O, Gerstoft J, Katzenstein T, Hansen AB, Skinhøj P, Pedersen C, Oestergaard L, Zilmer K, Ristola M, Girard PM, Vanhems P, Rockstroh J, Schmidt R, van Lunzen J, Degen O, Stellbrink HJ, Bogner J, Kosmidis J, Gargalianos P, Xylomenos G, Perdios J, Panos G, Filandras A, Karabatsaki E, Sambattakou H, Banhegyi D, Mulcahy F, Yust I, Turner D, Burke M, Pollack S, Hassoun G, Maayan S, Chiesi A, Mazeu I, Pristera R, Gabbuti A, Montesarchio E, Gargiulo M, Iacomi F, Vlassi C, Finazzi R, Galli M, Ridolfo A, Rozentale B, Aldins P, Chaplinskas S, Hemmer R, Staub T, Bruun J, Maeland A, Ormaasen V, Knysz B, Gasiorowski J, Horban A, Prokopowicz D, Wiercinska Drapalo A, Boron Kaczmarska A, Pynka M, Beniowski M, Mularska E, Trocha H, Antunes F, Valadas E, Mansinho K, Maltez F, Duiculescu D, Rakhmanova A, Vinogradova E, Buzunova S, Jevtovic D, Mokrás M, Staneková D, González Lahoz J, Soriano V, Martin Carbonero L, Labarga P, Clotet B, Jou A, Conejero J, Tural C, Gatell JM, Miró JM, Domingo P, Gutierrez M, Mateo G, Sambeat MA, Karlsson A, Persson PO, Flamholc L, Boffi E, Kravchenko E, Chentsova N, Barton S, Johnson AM, Mercey D, Johnson MA, Murphy M, Weber J, Scullard G, Fisher M, Brettle R, Gatell J, Gazzard B, Friis Møller N, Bannister W, Ellefson M, Borch A, Podlekareva D, Holkmann Olsen C, Kjaer J, Peters L, Reekie J, Raffanti S, Dieterch D, Becker S, Scarsella A, Fusco G, Most B, Balu R, Rana R, Beckerman R, Ising T, Fusco J, Irek R, Johnson B, Hirani A, DeJesus E, Pierone G, Lackey P, Irek C, Johnson A, Burdick J, Leon S, Arch J, Helm EB, Carlebach A, Müller A, Haberl A, Nisius G, Lennemann T, Stephan C, Bickel M, Mösch M, Gute P, Locher L, Lutz T, Klauke S, Knecht G, Khaykin P, Doerr HW, Stürmer M, Babacan E, von Hentig N, Beylot J, Dupon M, Longy Boursier M, Pellegrin JL, Ragnaud JM, Salamon R, Thiébaut R, Lewden C, Lawson Ayayi S, Mercié P, Moreau JF, Morlat P, Bernard N, Lacoste D, Malvy D, Neau D, Blaizeau MJ, Decoin M, Delveaux S, Hannapier C, Labarrère S, Lavignolle Aurillac V, Uwamaliya Nziyumvira B, Palmer G, Touchard D, Balestre E, Alioum A, Jacqmin Gadda H, Bonarek M, Coadou B, Gellie P, Nouts C, Bocquentin F, Dutronc H, Lafarie S, Aslan A, Pistonne T, Thibaut P, Vatan R, Chambon D, De La Taille C, Cazorla C, Ocho A, Viallard JF, Caubet O, Cipriano C, Lazaro E, Couzigou P, Castera L, Fleury H, Lafon ME, Masquelier B, Pellegrin I, Breilh D, Blanco P, Loste P, Caunègre L, Bonnal F, Farbos S, Ferrand M, Ceccaldi J, Tchamgoué S, De Witte S, Buy E, Alexander C, Barrios R, Braitstein P, Brumme Z, Chan K, Cote H, Gataric N, Geller J, Guillemi S, Harrigan PR, Harris M, Joy R, Levy A, Montaner J, Montessori V, Palepu A, Phillips E, Phillips P, Press N, Tyndall M, Wood E, Yip B, Bhagani S, Breen R, Byrne P, Carroll A, Cuthbertson Z, Dunleavy A, Geretti AM, Heelan B, Johnson M, Kinloch de Loes S, Lipman M, Madge S, Marshall N, Nair D, Nebbia G, Prinz B, Shah S, Swader L, Tyrer M, Youle M, Chaloner C, Grabowska H, Holloway J, Puradiredja J, Ransom D, Tsintas R, Bansi L, Fox Z, Harris E, Hill T, Lampe F, Lodwick R, Smith C, Amoah E, Booth C, Clewley G, Garcia Diaz A, Gregory B, Janossy G, Labbett W, Thomas M, Read R, Krentz H, Beckthold B, Schmeisser N, Alquézar A, Esteve A, Podzamczer D, Murillas J, Romero A, Agustí C, Agüero F, Ferrer E, Riera M, Segura F, Navarro G, Force L, Vilaró J, Masabeu A, García I, Guadarrama M, Montoliu A, Ortega N, Lazzari E, Puchol E, Sanchez M, Blanco JL, Garcia Alcaide F, Martinez E, Mallolas J, López Dieguez M, García Goez JF, Sirera G, Romeu J, Negredo E, Miranda C, Capitan MC, Olmo M, Barragan P, Saumoy M, Bolao F, Cabellos C, Peña C, Sala M, Cervantes M, Jose Amengual M, Navarro M, Penelo E, Barrufet P, Raper JL, Mugavero MJ, Willig JH, Schumacher J, Chang PW, Westfall AO, Cloud G, Lin HY, Acosta EP, Colette Kempf M, Allison JJ, Pisu M., NAPPA, SALVATORE, Mocroft, A, Mancuso, S, Antiretroviral Therapy Cohort Collaboration Mocroft, A, Sterne, Ja, Egger, M, May, M, Grabar, S, Furrer, H, Sabin, C, Fatkenheuer, G, Justice, A, Reiss, P, d'Arminio Monforte, A, Gill, J, Hogg, R, Bonnet, F, Kitahata, M, Staszewski, S, Casabona, J, Harris, R, Saag, M, Chêne, G, Costagliola, D, Dabis, F, D'Arminio Monforte, A, de Wolf, F, Ledergerber, B, Phillips, A, Weller, I, Sterne, J, Abgrall, S, Barin, F, Bentata, M, Billaud, E, Boué, F, Burty, C, Cabié, A, Cotte, L, De Truchis, P, Duval, X, Duvivier, C, Enel, P, Fredouille Heripret, L, Gasnault, J, Gaud, C, Gilquin, J, Katlama, C, Khuong, Ma, Lang, Jm, Lascaux, A, Launay, O, Mahamat, A, Mary Krause, M, Matheron, S, Meynard, Jl, Pavie, J, Pialoux, G, Pilorgé, F, Poizot Martin, I, Pradier, C, Reynes, J, Rouveix, E, Simon, A, Tattevin, P, Tissot Dupont, H, Viard, Jp, Viget, N, Pariente Khayat, A, Salomon, V, Jacquemet, N, Rivet, A, Guiguet, M, Kousignian, I, Lanoy, E, Lièvre, L, Potard, V, Selinger Leneman, H, Bouvet, E, Crickx, B, Ecobichon, Jl, Leport, C, Picard Dahan, C, Yeni, P, Tisne Dessus, D, Weiss, L, Salmon, D, Sicard, D, Auperin, I, Roudière, L, Fior, R, Delfraissy, Jf, Goujard, C, Jung, C, Lesprit, P, Desplanque, N, Meyohas, Mc, Picard, O, Cadranel, J, Mayaud, C, Bricaire, F, Herson, S, Clauvel, Jp, Decazes, Jm, Gerard, L, Molina, Jm, Diemer, M, Sellier, P, Berthé, H, Dupont, C, Chandemerle, C, Mortier, E, Honoré, P, Jeantils, V, Tassi, S, Mechali, D, Taverne, B, Gourdon, F, Laurichesse, H, Fresard, A, Lucht, F, Eglinger, P, Faller, Jp, Bazin, C, Verdon, R, Boibieux, A, Peyramond, D, Livrozet, Jm, Touraine, Jl, Trepo, C, Ravaux, I, Delmont, Jp, Moreau, J, Gastaut, Ja, Retornaz, F, Soubeyrand, J, Allegre, T, Blanc, Pa, Galinier, A, Ruiz, Jm, Lepeu, G, Granet Brunello, P, Esterni, Jp, Pelissier, L, Cohen Valensi, R, Nezri, M, Chadapaud, S, Laffeuillade, A, May, T, Rabaud, C, Raffi, F, Arvieux, C, Michelet, C, Borsa Lebas, F, Caron, F, Fraisse, P, Rey, D, Arlet Suau, E, Cuzin, L, Massip, P, Thiercelin Legrand, Mf, Yasdanpanah, Y, Pradinaud, R, 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Male ,Infectious diseases and international health [NCEBP 13] ,Lymphoma ,030312 virology ,Esophageal candidiasis ,Cohort Studies ,0302 clinical medicine ,Interquartile range ,030212 general & internal medicine ,AIDS-Related ,Lymphoma, AIDS-Related ,0303 health sciences ,Mortality rate ,Progressive multifocal leukoencephalopathy ,Hazard ratio ,Prognosis ,3. Good health ,Pathogenesis and modulation of inflammation [N4i 1] ,Infectious Diseases ,Combination ,Drug Therapy, Combination ,Female ,Infection and autoimmunity [NCMLS 1] ,Human ,Microbiology (medical) ,Adult ,medicine.medical_specialty ,Prognosi ,Anti-HIV Agents ,antiretroviral therapy ,Infectious Disease ,Article ,AIDS-Related Opportunistic Infection ,03 medical and health sciences ,Acquired immunodeficiency syndrome (AIDS) ,Drug Therapy ,Internal medicine ,medicine ,Humans ,AIDS-defining event ,Proportional Hazards Models ,AIDS-Related Opportunistic Infections/diagnosis/ mortality ,Acquired Immunodeficiency Syndrome/complications/diagnosis/drug ,therapy/ mortality ,Anti-HIV Agents/ therapeutic use ,AIDS-Related/diagnosis/mortality ,Acquired Immunodeficiency Syndrome ,AIDS-Related Opportunistic Infections ,business.industry ,Proportional hazards model ,Poverty-related infectious diseases [N4i 3] ,Anti-HIV Agent ,medicine.disease ,mortality ,Confidence interval ,Immunology ,Proportional Hazards Model ,Cohort Studie ,business - Abstract
Contains fulltext : 80963.pdf (Publisher’s version ) (Open Access) BACKGROUND: The extent to which mortality differs following individual acquired immunodeficiency syndrome (AIDS)-defining events (ADEs) has not been assessed among patients initiating combination antiretroviral therapy. METHODS: We analyzed data from 31,620 patients with no prior ADEs who started combination antiretroviral therapy. Cox proportional hazards models were used to estimate mortality hazard ratios for each ADE that occurred in >50 patients, after stratification by cohort and adjustment for sex, HIV transmission group, number of antiretroviral drugs initiated, regimen, age, date of starting combination antiretroviral therapy, and CD4+ cell count and HIV RNA load at initiation of combination antiretroviral therapy. ADEs that occurred in
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- 2009
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49. Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
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Lodi, Sara, Del Amo, Julia, Moreno, Santiago, Bucher, H. C., Furrer, Hansjakob, Logan, Roger, Sterne, Jonathan, Pérez-Hoyos, Santiago, Jarrín, Inma, Phillips, Andrew, Olson, Ashley, Van Sighem, Ard, Reiss, Peter, Sabin, C., Jose, Sophie, Justice, Amy, Goulet, Joseph, Miró, José M., Ferrer, Elena, Meyer, Laurence, Seng, Rémonie, Vourli, Georgia, Antoniadou, Anastasia, Dabis, Francois, Vandenhede, Mari Anne, Costagliola, Dominique, Abgrall, S., Hernán, Miguel A., Hernan, Miguel, Bansi, L., Hill, T., Dunn, D., Porter, K., Glabay, A., Orkin, C., Thomas, R., Jones, K., Fisher, M., Perry, N., Pullin, A., Churchill, D., Gazzard, B., Nelson, M., Asboe, D., Bulbeck, S., Mandalia, S., Clarke, J., Delpech, V., Anderson, J., Munshi, S., Post, F., Easterbrook, P., Khan, Y., Patel, P., Karim, F., Duffell, S., Gilson, R., Man, S. 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P., Sicard, D., Stieltjes, N., Michot, J., Bourdillon, F., Obenga, G., Escaut, L., Bolliot, C., Schneider, L., Iguertsira, M., Tomei, C., Dhiver, C., Tissot Dupont, H., Vallon, A., Gallais, J., Gallais, H., Durant, J., Mondain, V., Perbost, I., Cassuto, J. P., Karsenti, J. M., Venti, H., Ceppi, C., Krivitsky, J. A., Bouchaud, O., Honore, P., Delgado, J., Rouzioux, C., Burgard, M., Boufassa, L., Peynet, J., Pérez-Hoyos, S., Del Amo, J., Alvarez, D., Monge, S., Muga, R., Sanvisens, A., Tor, J., Rivas, I., Vallecillo, G., Del Romero, J., Raposo, P., Rodríguez, C., Vera, M., Hurtado, I., Belda, J., Fernandez, E., Alastrue, I., Santos, C., Tasa, T., Juan, A., Trullen, J., Garcia De Olalla, P., Cayla, J., Masdeu, E., Knobel, H., Mirò, J. M., Sambeat, M. A., Guerrero, R., Rivera, E., Marco, A., Quintana, M., Gonzalez, C., Castilla, J., Guevara, M., De Mendoza, C., Zahonero, N., Ortíz, M., Paraskevis, D., Touloumi, G., Pantazis, N., Bakoyannis, G., Gioukari, V., Antoniadou, A., Papadopoulos, A., Petrikkos, G., Daikos, G., Psichogiou, M., Gargalianos-Kakolyris, P., Xylomenos, G., Katsarou, O., Kouramba, A., Ioannidou, P., Kordossis, T., Kontos, A., Lazanas, M., Chini, M., Tsogas, N., Panos, G., Paparizos, V., Leuow, K., Kourkounti, S., Sambatakou, H., Mariolis, I., Skoutelis, A., Papastamopoulos, V., Baraboutis, I., Internal medicine, APH - Aging & Later Life, Pediatric surgery, CCA - Innovative therapy, ICaR - Circulation and metabolism, ICaR - Ischemia and repair, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, Landsteiner Laboratory, AII - Amsterdam institute for Infection and Immunity, Infectious diseases, Global Health, Center of Experimental and Molecular Medicine, APH - Amsterdam Public Health, AII - Inflammatory diseases, and ARD - Amsterdam Reproduction and Development
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Opportunistic infection ,AIDS-Related Opportunistic Infections ,Immunology ,Population ,Retinitis ,HIV Infections ,Article ,17 Psychology And Cognitive Sciences ,Young Adult ,Immune reconstitution inflammatory syndrome ,Antiretroviral Therapy, Highly Active ,Neoplasms ,Virology ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,education ,Inverse probability weighting ,Aged ,education.field_of_study ,business.industry ,Developed Countries ,Incidence ,Progressive multifocal leukoencephalopathy ,Hazard ratio ,HIV ,virus diseases ,11 Medical And Health Sciences ,Middle Aged ,06 Biological Sciences ,medicine.disease ,United States ,Europe ,Infectious Diseases ,Anti-Retroviral Agents ,Unmasking ,Female ,Cytomegalovirus retinitis ,business - Abstract
Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.
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- 2014
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50. Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
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Irigoyen, C. Moreno, S. Antela, A. Casado, J.L. Dronda, F. Moreno, A. Pérez, M.J. López, D. Gutiérrez, C. Hernández, B. Pumares, M. Martí, P. García, L. Page, C. García, F. Hernández, J. Peña, A. Muñoz, L. Parra, J. Viciana, P. Leal, M. López-Cortés, L.F. Trastoy, M. Mata, R. Justice, A.C. Fiellin, D.A. Rimland, D. Jones-Taylor, C. Oursler, K.A. Titanji, R. Brown, S. Garrison, S. Rodriguez-Barradas, M. Masozera, N. Goetz, M. Leaf, D. Simberkoff, M. Blumenthal, D. Leung, J. Butt, A. Hoffman, E. Gibert, C. Peck, R. Mattocks, K. Braithwaite, S. Brandt, C. Bryant, K. Cook, R. Conigliaro, J. Crothers, K. Chang, J. Crystal, S. Day, N. Erdos, J. Freiberg, M. Kozal, M. Gandhi, N. Gaziano, M. Gerschenson, M. Good, B. Gordon, A. Goulet, J.L. Kraemer, K. Lim, J. Maisto, S. Miller, P. Mole, L. O'Connor, P. Papas, R. Robins, J.M. Rinaldo, C. Roberts, M. Samet, J. Tierney, B. Whittle, J. Babiker, A. Brettle, R. Darbyshire, J. Gilson, R. Goldberg, D. Hawkins, D. Jaffe, H. Johnson, A. McLean, K. Pillay, D. Cursley, A. Ewings, F. Fairbrother, K. Louisa Gnatiuc, S.L. Murphy, B. Douglas, G. Kennedy, N. Pritchard, J. Andrady, U. Rajda, N. Maw, R. McKernan, S. Drake, S. Gilleran, G. White, D. Ross, J. Toomer, S. Hewart, R. Wilding, H. Woodward, R. Dean, G. Heald, L. Horner, P. Glover, S. Bansaal, D. Eduards, S. Carne, C. Browing, M. Das, R. Stanley, B. Estreich, S. Magdy, A. O'Mahony, C. Fraser, P. Hayman, B. Jebakumar, S.P.R. Joshi, U. Ralph, S. Wade, A. Mette, R. Lalik, J. Summerfield, H. El-Dalil, A. France, J.A. White, C. Robertson, R. Gordon, S. McMillan, S. Morris, S. Lean, C. Vithayathil, K. McLean, L. Winter, A. Gale, D. Jacobs, S. Tayal, S. Short, L. Roberts, M. Green, S. Williams, G. Sivakumar, K. Bhattacharyya, N.D. Monteiro, E. Minton, J. Dhar, J. Nye, F. De Souza, C.B. Isaksen, A. McDonald, L. McLean, K. Franca, A. Hawkins, D. William, L. Jendrulek, I. Peters, B. Shaunak, S. El-Gadi, S. Easterbrook, P.J. Mazhude, C. Gilson, R. Johnstone, R. Fakoya, A. McHale, J. Waters, A. Kegg, S. Mitchell, S. Byrne, P. Johnson, M. Rice, P. Fidler, S. Mullaney, S.A. McCormack, S. David, D. Melville, R. Phillip, K. Balachandran, T. Mabey-Puttock, S. Sukthankar, A. Murphy, C. Wilkins, E. Ahmad, S. Tayal, S. Haynes, J. Evans, E. Ong, E. Das, R. Grey, R. Meaden, J. Bignell, C. Loay, D. Peacock, K. Girgis, M.R. Morgan, B. Palfreeman, A. Wilcox, J. Tobin, J. Tucker, L. Saeed, A.M. Chen, F. Deheragada, A. Williams, O. Lacey, H. Herman, S. Kinghorn, D. Devendra, V.S. Wither, J. Dawson, S. Rowen, D. Harvey, J. Wilkins, E. Bridgwood, A. Singh, G. Chauhan, M. Kellock, D. Young, S. Dannino, S. Kathir, Y. Rooney, G. Currie, J. Fitzgerald, M. Devendra, S. Keane, F. Booth, G. Green, T. Arumainayyagam, J. Chandramani, S. Rajamanoharan, S. Robinson, T. Curless, E. Gokhale, R. Tariq, A. Roberts, M. Williams, O. Luzzi, G. FitzGerald, M. Fairley, I. Wallis, F. Smit, E. Ward, F. Molina, J.M. Loze, B. Morlat, P. Bonarek, M. Bonnet, F. Nouts, C. Louis, I. Raffi, F. Reliquet, V. 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Vinceneux, P. Simonpoli, A.M. Zeng, A. Fournier, L. Fuzibet, J.G. Sohn, C. Rosenthal, E. Quaranta, M. Dellamonica, P. Chaillou, S. Sabah, M. Audhuy, B. Schieber, A. Moreau, P. Niault, M. Vaillant, O. Huchon, G. Compagnucci, A. De Lacroix Szmania, I. Richier, L. Lamaury, I. Saint-Dizier, F. Garipuy, D. Gastaut, J.A. Drogoul, M.P. Poizot Martin, I. Fabre, G. Lambert De Cursay, G. Abraham, B. Perino, C. Lagarde, P. David, F. Roche-Sicot, J. Saraux, J.L. Leprêtre, A. Fampin, B. Uludag, A. Morin, A.S. Bletry, O. Zucman, D. Regnier, A. Girard, J.J. Quinsat, D.T. Heripret, L. Grihon, F. Houlbert, D. Ruel, M. Chemlal, K. Caron, F. Debab, Y. Tremollieres, F. Perronne, V. Lepeu, G. Slama, B. Perré, P. Miodovski, C. Guermonprez, G. Dulioust, A. Boudon, P. Malbec, D. Patey, O. Semaille, C. Deville, J. Remy, G. Béguinot, I. Galanaud, P. Boue, F. Chambrin, V. Pignon, C. Estocq, G.A. Levy, A. Delfraissy, J.F. Goujard, C. Duracinsky, M. Le Bras, P. Ngussan, M.S. Peretti, D. Medintzeff, N. Lambert, T. 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Sereni, D. Lascoux, C. Delgado, J. Rouzioux, C. Burgard, M. Boufassa, L. Peynet, J. Pérez-Hoyos, S. Del Amo, J. Alvarez, D. Monge, S. Muga, R. Sanvisens, A. Clotet, B. Tor, J. Bolao, F. Rivas, I. Vallecillo, G. Del Romero, J. Raposo, P. Rodríguez, C. Vera, M. Hurtado, I. Belda, J. Fernandez, E. Alastrue, I. Santos, C. Tasa, T. Juan, A. Trullen, J. Garcia De Olalla, P. Cayla, J. Masdeu, E. Knobel, H. Mirò, J.M. Sambeat, M.A. Guerrero, R. Rivera, E. Guerrero, R. Marco, A. Quintana, M. Gonzalez, C. Castilla, J. Guevara, M. De Mendoza, C. Zahonero, N. Ortíz, M. Paraskevis, D. Touloumi, G. Pantazis, N. Bakoyannis, G. Gioukari, V. Antoniadou, A. Papadopoulos, A. Petrikkos, G. Daikos, G. Psichogiou, M. Gargalianos-Kakolyris, P. Xylomenos, G. Katsarou, O. Kouramba, A. Ioannidou, P. Kordossis, T. Kontos, A. Lazanas, M. Chini, M. Tsogas, N. Panos, G. Paparizos, V. Leuow, K. Kourkounti, S. Sambatakou, H. Mariolis, I. Skoutelis, A. Papastamopoulos, V. Baraboutis, I. The HIV-CAUSAL Collaboration
- Subjects
virus diseases - Abstract
Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis. Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting. Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis. Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
- Published
- 2014
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