600 results on '"Lanari M."'
Search Results
2. MINERvA neutrino detector response measured with test beam data
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MINERvA Collaboration, Aliaga, L., Altinok, O., Del Castillo, C. Araujo, Bagby, L., Bellantoni, L., Bergan, W. F., Bodek, A., Bradford, R., Bravar, A., Budd, H., Butkevich, A., Caicedo, D. A. Martinez, Carneiro, M. F., Christy, M. E., Chvojka, J., da Motta, H., Devan, J., Diaz, G. A., Dytman, S. A., Eberly, B., Felix, J., Fields, L., Fine, R., Flight, R., Gago, A. M., Gingu, C., Golan, T., Gomez, A., Gran, R., Harris, D. A., Higuera, A., Howley, I. J., Hurtado, K., Kleykamp, J., Kordosky, M., Lanari, M., Le, T., Leister, A. J., Lovlein, A., Maher, E., Mann, W. A., Marshall, C. M., McFarland, K. S., McGivern, C. L., McGowan, A. M., Messerly, B., Miller, J., Miller, W., Mislivec, A., Morfin, J. G., Mousseau, J., Muhlbeier, T., Naples, D., Nelson, J. K., Norrick, A., Ochoa, N., OConnor, C. D., Osmanov, B., Osta, J., Paolone, V., Patrick, C. E., Patrick, L., Perdue, G. N., Lara, C. E. Perez, Rakotondravohitra, L., Ramirez, M. A., Ray, H., Ren, L., Rodrigues, P. A., Rubinov, P., Rude, C. R., Ruterbories, D., Schellman, H., Schmitz, D. W., Salinas, C. J. Solano, Tagg, N., Tice, B. G., Urrutia, Z., Valencia, E., Walton, T., Westerberg, A., Wolcott, J., Woodward, N., Wospakrik, M., Zavala, G., Zhang, D., and Ziemer, B. P.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The MINERvA collaboration operated a scaled-down replica of the solid scintillator tracking and sampling calorimeter regions of the MINERvA detector in a hadron test beam at the Fermilab Test Beam Facility. This article reports measurements with samples of protons, pions, and electrons from 0.35 to 2.0 GeV/c momentum. The calorimetric response to protons, pions, and electrons are obtained from these data. A measurement of the parameter in Birks' law and an estimate of the tracking efficiency are extracted from the proton sample. Overall the data are well described by a Geant4-based Monte Carlo simulation of the detector and particle interactions with agreements better than 4%, though some features of the data are not precisely modeled. These measurements are used to tune the MINERvA detector simulation and evaluate systematic uncertainties in support of the MINERvA neutrino cross section measurement program., Comment: as accepted by NIM A
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- 2015
3. Demonstration of Communication using Neutrinos
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Stancil, D. D., Adamson, P., Alania, M., Aliaga, L., Andrews, M., Del Castillo, C. Araujo, Bagby, L., Alba, J. L. Bazo, Bodek, A., Boehnlein, D., Bradford, R., Brooks, W. K., Budd, H., Butkevich, A., Caicedo, D. A. M., Capista, D. P., Castromonte, C. M., Chamorro, A., Charlton, E., Christy, M. E., Chvojka, J., Conrow, P. D., Danko, I., Day, M., Devan, J., Downey, J. M., Dytman, S. A., Eberly, B., Fein, J. R., Felix, J., Fields, L., Fiorentini, G. A., Gago, A. M., Gallagher, H., Gran, R., Grange, J., Griffin, J., Griffin, T., Hahn, E., Harris, D. A., Higuera, A., Hobbs, J. A., Hoffman, C. M., Hughes, B. L., Hurtado, K., Judd, A., Kafka, T., Kephart, K., Kilmer, J., Kordosky, M., Kulagin, S. A., Kuznetsov, V. A., Lanari, M., Le, T., Lee, H., Loiacono, L., Maggi, G., Maher, E., Manly, S., Mann, W. A., Marshall, C. M., McFarland, K. S., Mislivec, A., McGowan, A. M., Morfin, J. G., da Motta, H., Mousseau, J., Nelson, J. K., Niemiec-Gielata, J. A., Ochoa, N., Osmanov, B., Osta, J., Palomino, J. L., Paradis, J. S., Paolone, V., Park, J., Pena, C., Perdue, G., Lara, C. E. Perez, Peterman, A. M., Pla-Dalmau, A., Pollock, B., Prokoshin, F., Ransome, R. D., Ray, H., Reyhan, M., Rubinov, P., Ruggiero, D., Sands, O. S., Schellman, H., Schmitz, D. W., Schulte, E. C., Simon, C., Salinas, C. J. Solano, Stefanski, R., Stevens, R. G., Tagg, N., Takhistov, V., Tice, B. G., Tilden, R. N., Velasquez, J. P., Vergalosova, I., Voirin, J., Walding, J., Walker, B. J., Walton, T., Wolcott, J., Wytock, T. P., Zavala, G., Zhang, D., Zhu, L. Y., and Ziemer, B. P.
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High Energy Physics - Experiment - Abstract
Beams of neutrinos have been proposed as a vehicle for communications under unusual circumstances, such as direct point-to-point global communication, communication with submarines, secure communications and interstellar communication. We report on the performance of a low-rate communications link established using the NuMI beam line and the MINERvA detector at Fermilab. The link achieved a decoded data rate of 0.1 bits/sec with a bit error rate of 1% over a distance of 1.035 km, including 240 m of earth., Comment: 10 pages, 7 figures, updated with final figures used in Modern Physics Letters A publication
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- 2012
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4. Eligibility criteria for pediatric patients who may benefit from anti SARS-CoV-2 monoclonal antibody therapy administration: an Italian inter-society consensus statement
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Lanari, M., Venturini, E., Pierantoni, L., Stera, G., Castelli Gattinara, G., Esposito, S. M. R., Favilli, S., Franzoni, E., Fusco, E., Lionetti, P., Maffeis, C., Marseglia, G., Massella, L., Midulla, F., Zanobini, A., Zecca, M., Villani, A., Staiano, A., Galli, L., Blasi, F., Di Giorgio, A., Dona, D., Licari, A., Martinelli, M., Mastrangelo, A., Miraglia del Giudice, M., Nicolini, G., Pugliese, F., Striano, P., Valerio, G., Lanari, M., Venturini, E., Pierantoni, L., Stera, G., Castelli Gattinara, G., Esposito, S. M. R., Favilli, S., Franzoni, E., Fusco, E., Lionetti, P., Maffeis, C., Marseglia, G., Massella, L., Midulla, F., Zanobini, A., Zecca, M., Villani, A., Staiano, A., Galli, L., Blasi, F., Di Giorgio, A., Dona, D., Licari, A., Martinelli, M., Mastrangelo, A., Miraglia del Giudice, M., Nicolini, G., Pugliese, F., Striano, P., Valerio, G., Lanari M., Venturini E., Pierantoni L., Stera G., Castelli Gattinara G., Esposito S.M.R., Favilli S., Franzoni E., Fusco E., Lionetti P., Maffeis C., Marseglia G., Massella L., Midulla F., Zanobini A., Zecca M., Villani A., Staiano A., Galli L., Blasi F., Di Giorgio A., Dona D., Licari A., Martinelli M., Mastrangelo A., Miraglia del Giudice M., Nicolini G., Pugliese F., Striano P., Valerio G., Lanari, M, Venturini, E, Pierantoni, L, Castelli Gattinara, G. Esposito S. M. R., Favilli, S, Franzoni, E, Marseglia, G, Massella, L, Zecca, M, Villani, A, Staiano, A, Galli, L, Blasi, F, and Donà, D.
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Monoclonal antibody ,Consensus ,Adolescent ,COVID19 ,Consensu ,Review ,Antibodies, Monoclonal, Humanized ,Adolescents ,Pediatrics ,Antiviral Agents ,RJ1-570 ,Drug Combination ,Humans ,Age Factor ,Child ,Societies, Medical ,Antiviral Agent ,Risk Factor ,Patient Selection ,Age Factors ,Antibodies, Monoclonal ,COVID-19 ,Settore MED/38 ,Antibodies, Neutralizing ,COVID-19 Drug Treatment ,Drug Combinations ,Italy ,Risk factors ,Risk Factors ,Human - Abstract
The fast diffusion of the SARS-CoV-2 pandemic have called for an equally rapid evolution of the therapeutic options.The Human recombinant monoclonal antibodies (mAbs) have recently been approved by the Food and Drug Administration (FDA) and by the Italian Medicines Agency (AIFA) in subjects aged ≥12 with SARS-CoV-2 infection and specific risk factors.Currently the indications are specific for the use of two different mAbs combination: Bamlanivimab+Etesevimab (produced by Eli Lilly) and Casirivimab+Imdevimab (produced by Regeneron).These drugs have shown favorable effects in adult patients in the initial phase of infection, whereas to date few data are available on their use in children.AIFA criteria derived from the existing literature which reports an increased risk of severe COVID-19 in children with comorbidities. However, the studies analyzing the determinants for progression to severe disease are mainly monocentric, with limited numbers and reporting mostly generic risk categories.Thus, the Italian Society of Pediatrics invited its affiliated Scientific Societies to produce a Consensus document based on the revision of the criteria proposed by AIFA in light of the most recent literature and experts’ agreement.This Consensus tries to detail which patients actually have the risk to develop severe disease, analyzing the most common comorbidities in children, in order to detail the indications for mAbs administration and to guide the clinicians in identifying eligible patients.
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- 2022
5. MINERvA neutrino detector response measured with test beam data
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Aliaga, L., Altinok, O., Araujo Del Castillo, C., Bagby, L., Bellantoni, L., Bergan, W.F., Bodek, A., Bradford, R., Bravar, A., Budd, H., Butkevich, A., Martinez Caicedo, D.A., Carneiro, M.F., Christy, M.E., Chvojka, J., da Motta, H., Devan, J., Díaz, G.A., Dytman, S.A., Eberly, B., Felix, J., Fields, L., Fine, R., Flight, R., Gago, A.M., Gingu, C., Golan, T., Gomez, A., Gran, R., Harris, D.A., Higuera, A., Howley, I.J., Hurtado, K., Kleykamp, J., Kordosky, M., Lanari, M., Le, T., Leister, A.J., Lovlein, A., Maher, E., Mann, W.A., Marshall, C.M., McFarland, K.S., McGivern, C.L., McGowan, A.M., Messerly, B., Miller, J., Miller, W., Mislivec, A., Morfín, J.G., Mousseau, J., Muhlbeier, T., Naples, D., Nelson, J.K., Norrick, A., Ochoa, N., O׳Connor, C.D., Osmanov, B., Osta, J., Paolone, V., Patrick, C.E., Patrick, L., Perdue, G.N., Pérez Lara, C.E., Rakotondravohitra, L., Ray, H., Ren, L., Rodrigues, P.A., Rubinov, P., Rude, C.R., Ruterbories, D., Schellman, H., Schmitz, D.W., Solano Salinas, C.J., Tagg, N., Tice, B.G., Urrutia, Z., Valencia, E., Walton, T., Westerberg, A., Wolcott, J., Woodward, N., Wospakrik, M., Zavala, G., Zhang, D., and Ziemer, B.P.
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- 2015
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6. A sensor-based ambulatory assessment of gross-motor development in school-children: Influence of age, sex, and anthropometry in the I-MOVE study
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Stagni, R., primary, Masini, A., additional, Toselli, S., additional, Bragonzoni, L., additional, Ceciliani, A., additional, Lanari, M., additional, Sansavini, A., additional, Tessari, A., additional, Dallolio, L., additional, and Bisi, M.C., additional
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- 2022
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7. Congenital cytomegalovirus infection: patterns of fetal brain damage
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Gabrielli, L., Bonasoni, M.P., Santini, D., Piccirilli, G., Chiereghin, A., Petrisli, E., Dolcetti, R., Guerra, B., Piccioli, M., Lanari, M., Landini, M.P., and Lazzarotto, T.
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- 2012
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8. Numerical study of contributions of shock wave and gas penetration toward induced rock damage during blasting
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Lanari, M. and Fakhimi, A.
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- 2015
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9. Impact of novel coronavirus Disease-19 (COVID-19) pandemic in Italian pediatric emergency departments: a national survey
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Talarico V., Pinto L., Marseglia G. L., Centonze A., Cristofaro C., Reina R., Nocerino A., Lubrano R., Zampogna S., Arrighini A., Barbieri M. A., Bondone C., Bressan S., Corsi V., Chiossi M., Cortis E., Crespin L., Cualbu A., Da Dalt L., De Donno V., De Filippo M., Di Stefano A., Ferrante P., Guidi B., Lamborghini A., Lanari M., Malorgio C., Manieri S., Masi S., Masiero S., Messini B., Mirauda M. P., Musolino A. M., Nigro R., Parisi G., Parri N., Pettoello-Mantovani M., Quarantiello F., Ponticiello E., Romero S., Savasta S., Sequi E., Simonetti D. M. L., Tappi E., Urbino A. F., Vianelli P., Zangardi T., Talarico V., Pinto L., Marseglia G.L., Centonze A., Cristofaro C., Reina R., Nocerino A., Lubrano R., Zampogna S., Arrighini A., Barbieri M.A., Bondone C., Bressan S., Corsi V., Chiossi M., Cortis E., Crespin L., Cualbu A., Da Dalt L., De Donno V., De Filippo M., Di Stefano A., Ferrante P., Guidi B., Lamborghini A., Lanari M., Malorgio C., Manieri S., Masi S., Masiero S., Messini B., Mirauda M.P., Musolino A.M., Nigro R., Parisi G., Parri N., Pettoello-Mantovani M., Quarantiello F., Ponticiello E., Romero S., Savasta S., Sequi E., Simonetti D.M.L., Tappi E., Urbino A.F., Vianelli P., and Zangardi T.
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Pediatric emergency ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Disease ,COVID-19 ,healthcare workers ,pediatric emergency ,personal protective equipment ,03 medical and health sciences ,0302 clinical medicine ,Clinical Protocols ,030225 pediatrics ,Surveys and Questionnaires ,Health care ,Epidemiology ,Pandemic ,medicine ,Surveys and Questionnaire ,Humans ,030212 general & internal medicine ,Clinical Protocol ,Child ,Personal protective equipment ,Infection Control ,business.industry ,Pediatric Emergency Medicine ,Research ,lcsh:RJ1-570 ,lcsh:Pediatrics ,medicine.disease ,Hospitalization ,Italy ,Preparedness ,Healthcare worker ,Medical emergency ,Triage ,business ,Emergency Service, Hospital ,Human - Abstract
Background Coronavirus Disease-19 (COVID-19) has rapidly become a pandemic emergency, distressing health systems in each affected country. Preparation strategies for managing this pandemic have been keys to face the COVID-19 surge all over the world and all levels of care. Materials and Methods During the epidemic, the Italian society of pediatric emergency-urgency (SIMEUP) promoted a national survey aiming to evaluate preparedness and response of pediatric emergency departments (PED) critical in ensuring optimal management of COVID-19 cases. Results Our results suggest that Italian PED have promptly set a proactive approach to the present emergency. 98.9% of the hospitals have defined special pathways and assistive protocols concerning the management of pediatric COVID-19 cases. The highest percentage of application of the measures for preventive and protective for COVID-19 concerned the use of personal protective equipments. Conclusions Results show that the following measures for pediatric patients, admitted in PED, have been promptly implemented throughout the whole country: eg. use of protective devices, pre-triage of patients accessing the hospital. Despite COVID-19 being a new threat, we have shown that by developing an easy-to-follow decision algorithm and clear plans for the interventional platform teams, we can ensure optimal health care workers and patients’ safety.
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- 2021
10. COVID-19: How the pandemic has increased food insecurity and altered the Italian families’ diet
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Dondi A., Candela E., Morigi F., Lenzi J., Lanari M., Dondi A., Candela E., Morigi F., Lenzi J., and Lanari M.
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Junk food ,Social determinants of health ,Food insecurity ,Pandemic ,Family ,Body weight ,Covid-19 - Abstract
Background - The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic and subsequent containment measures are causing a worldwide increase in food insecurity (FI). Food insecurity has been related to a number of negative health implications, particularly for the most vulnerable population, including children and adolescents. Aim - To investigate the effects on FI during the lockdown in Italy and the changes in eating habits and body weight in the paediatric population 6 months after the beginning of the pandemic. Materials and Methods - An online anonymous cross-sectional survey was elaborated and proposed to the parents of children < 18 years old. Results - 8.3% reported that their families were at risk of FI before the outbreak of SARSCoV-2 pandemic. This percentage dramatically doubled after the pandemic began. Moreover, 27.3% of the parents reported that their children were eating more, with a concomitant increase in “junk food” consumption. About one third of respondents declared an increase in children’s weight, while weight loss were uncommon and prevailed among adolescents. It was observed that parents’ higher age, higher parents’ school grade and working parents were protective factors against FI. Conclusion - Since the SARS-CoV-2 pandemic is requiring restrictions again, it is crucial that health care and social protection programmes take into account concepts of equity and sustainability to ensure adequate food and nutrition security for everyone.
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- 2021
11. EFECTOS DE LA SELECCIÓN DIRIGIDA EN POBLACIONES DE GALLINAS ARAUCANAS EN PATAGONIA NORTE ARGENTINA
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Subiabre M. S., Lanari M. R. ,Von Thungen J., Bunge M. M.
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Animal culture ,SF1-1100 ,Genetics ,QH426-470 - Published
- 2011
12. Update on the prevention, diagnosis and management of cytomegalovirus infection during pregnancy
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Lazzarotto, T., Guerra, B., Gabrielli, L., Lanari, M., and Landini, M.P.
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- 2011
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13. Clinical Outcome of Discordant Empirical Therapy and Risk Factors Associated to Treatment Failure in Children Hospitalized for Urinary Tract Infections
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Autore G., Neglia C., Di Costanzo M., Ceccoli M., Vergine G., La Scola C., Malaventura C., Falcioni A., Iacono A., Crisafi A., Iughetti L., Conte M. L., Pierantoni L., Gatti C., Biasucci G., Esposito S., Argentiero A., Bernardi L., Dal Canto G., Cortina I., Capra M. E., Benincasa C., Addeo A., Saia R. E., Lelli F., Pession A., Pasini A., Baccelli F., Bruni L., Gallotta G., Corvaglia A., Lanari M., Suppiej A., Cafolla C., Boselli F., Valletta E., Venturoli V., Casadio L., Polenzani I., Marchetti F., De Fanti A., Autore G., Neglia C., Di Costanzo M., Ceccoli M., Vergine G., La Scola C., Malaventura C., Falcioni A., Iacono A., Crisafi A., Iughetti L., Conte M.L., Pierantoni L., Gatti C., Biasucci G., Esposito S., Argentiero A., Bernardi L., Dal Canto G., Cortina I., Capra M.E., Benincasa C., Addeo A., Saia R.E., Lelli F., Pession A., Pasini A., Baccelli F., Bruni L., Gallotta G., Corvaglia A., Lanari M., Suppiej A., Cafolla C., Boselli F., Valletta E., Venturoli V., Casadio L., Polenzani I., Marchetti F., and De Fanti A.
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Antibiotic resistance ,Antibiotic failure ,Discordant antibiotic ,Pediatrics, Perinatology and Child Health ,Socio-culturale ,Empirical therapy ,Urinary tract infections ,antibiotic failure ,antibiotic resistance ,empirical therapy ,discordant antibiotic ,urinary tract infections - Abstract
With the spread of antibiotic resistance in pediatric urinary tract infections (UTIs), more patients are likely to be started empirically on antibiotics to which pathogens are later found to be resistant (discordant therapy). However, in-vivo effectiveness may be different from in-vitro susceptibility. Aims of this study were to describe clinical outcomes of discordant empirical treatments in pediatric UTIs and to investigate risk factors associated to treatment failure. This observational, retrospective study was conducted on children hospitalized for febrile UTIs with positive urine culture and started on discordant empirical therapy. Failure rates of discordant treatments and associated risk factors were investigated. A total of 142/1600 (8.9%) patients were treated with inadequate empirical antibiotics. Clinical failure was observed in 67/142 (47.2%) patients, with no fatal events. Higher failure rates were observed for combinations of penicillin and beta-lactamase inhibitors (57.1%). Significant risk factors for failure of discordant treatment were history of recurrent UTIs (95% CI: 1.13–9.98, OR: 3.23, p < 0.05), recent use of antibiotics (95% CI: 1.46–21.82, OR: 5.02, p < 0.01), infections caused by Pseudomonas aeruginosa (95% CI: 1.85–62.10, OR: 7.30, p < 0.05), and empirical treatment with combinations of penicillin and beta-lactamase inhibitors (95% CI: 0.94–4.03, OR: 1.94, p = 0.05). This study showed that discordant empirical treatments may still be effective in more than half of pediatric UTIs. Clinical effectiveness varies between different discordant antibiotics in pediatric UTIs, and patients presenting risk factors for treatment failure may need a differentiated empirical approach.
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- 2022
14. Children with Covid-19 in Pediatric Emergency Departments in Italy
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Parri, N., Lenge, M., Buonsenso, D., Cantoni, B., Arrighini, A., Romanengo, M., Urbino, A., Da Dalt, L., Verdoni, L., Limoli, G., Musolino, A. M., Pilotto, C., La Fauci, G., Chiossi, M., Agostiniani, R., Plebani, A., Barbieri, M. A., Lanari, M., Masi, S., Giacalone, M., Leo, M. C., Falconi, M., Indolfi, G., D'Antiga, L., Mazza, A., De Martiis, D., Bertolozzi, G., Marchisio, P., Chidini, G., Calderini, E., Agostoni, C., Gori, A., Bondone, C., Dona', D., Todeschini, M., Scilipoti, M., Cogo, P., Ginocchio, F., Russotto, V. S., Biban, P., Stera, G., Margherita, M., Maiandi, S., Tubino, B., Chiaretti, A., Zampogna, S., Mazzuca, A., Parri N., Lenge M., Buonsenso D., Cantoni B., Arrighini A., Romanengo M., Urbino A., Da Dalt L., Verdoni L., Limoli G., Musolino A.M., Pilotto C., La Fauci G., Chiossi M., Agostiniani R., Plebani A., Barbieri M.A., Lanari M., Masi S., Giacalone M., Leo M.C., Falconi M., Indolfi G., D'Antiga L., Mazza A., De Martiis D., Bertolozzi G., Marchisio P., Chidini G., Calderini E., Agostoni C., Gori A., Bondone C., Dona D., Todeschini M., Scilipoti M., Cogo P., Ginocchio F., Russotto V.S., Biban P., Stera G., Margherita M., Maiandi S., Tubino B., Chiaretti A., Zampogna S., and Mazzuca A.
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Pediatric emergency ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,China ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,030204 cardiovascular system & hematology ,Betacoronavirus ,COVID-19 ,Child ,Humans ,Italy ,SARS-CoV-2 ,Coronavirus Infections ,Emergency Service, Hospital ,Pandemics ,Hospital ,03 medical and health sciences ,0302 clinical medicine ,Correspondence ,Pandemic ,medicine ,Viral ,030212 general & internal medicine ,Emergency Service ,Betacoronaviru ,business.industry ,Coronavirus Infection ,Pneumonia ,General Medicine ,Family medicine ,Cohort ,business ,Human - Abstract
This letter describes a cohort of 100 children younger than 18 years of age with RT-PCR-confirmed Covid-19 who were assessed in 17 pediatric emergency departments in Italy. The descriptive results are compared with previously published results involving children in China and the United States.
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- 2020
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15. How to manage children if a second wave of COVID-19 occurs
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Esposito S., Zona S., Vergine G., Fantini M., Marchetti F., Stella M., Valletta E., Biasucci G., Lanari M., Dodi I., Bigi M., Magista A. M., Vaienti F., Cella A., Affanni P., Re M. C., Sambri V., Principi N., Ancora G., Rizzi S., Greco M., Iacono A., Turla G., Angelini R., Filice E., Fugetto F., Cortina I., Mystkowsky R., Veronesi L., Colucci M. E., Rubini M., Maffini V., Perrone S., Castellone E., Esposito S., Zona S., Vergine G., Fantini M., Marchetti F., Stella M., Valletta E., Biasucci G., Lanari M., Dodi I., Bigi M., Magista A.M., Vaienti F., Cella A., Affanni P., Re M.C., Sambri V., Principi N., Ancora G., Rizzi S., Greco M., Iacono A., Turla G., Angelini R., Filice E., Fugetto F., Cortina I., Mystkowsky R., Veronesi L., Colucci M.E., Rubini M., Maffini V., Perrone S., and Castellone E.
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Pulmonary and Respiratory Medicine ,2019-20 coronavirus outbreak ,Infectious Diseases ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,Medicine ,COVID-19, Children ,business ,Virology - Abstract
NION DISPONIBILE
- Published
- 2020
16. Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020
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Garazzino, S., Montagnani, C., Dona, D., Meini, A., Felici, E., Vergine, G., Bernardi, S., Giacchero, R., Vecchio, A. L., Marchisio, P., Nicolini, G., Pierantoni, L., Rabbone, I., Banderali, G., Denina, M., Venturini, E., Krzysztofiak, A., Badolato, R., Bianchini, S., Galli, L., Villani, A., Castelli-Gattinara, G., Salvini, F., Abbagnato, L., Castagnola, E., Dodi, I., Ghitti, C., Lippi, P., Agostiniani, R., Cherubini, S., Valentini, P., Gianino, P., Vaccaro, A., Manzoni, P., Verna, P., Comberiati, P., Di Filippo, P., Gallia, P., Battezzati, G., Fiore, L., Dalmazzo, C., Tappi, E., Lazzerini, M., Tovo, P. -A., Scolfaro, C., Pruccoli, G., Ramenghi, U., Giaquinto, C., da Dalt, L., Tornese, G., Berlese, P., Plebani, A., Manno, E. C., Santilli, V., Lancella, L., Cursi, L., Campana, A., Bozzola, E., Bosis, S., Lanari, M., Pecoraro, C., Del Barba, P., Nicastro, E., Esposito, S., Zuccotti, G. V., Corsello, G., Cardinale, F., Tocco, A. M., Ballardini, G., Agostoni, C., Chiappini, E., Indolfi, G., Anna, B., Cazzato, S., Zavarise, G., Pignata, C., Marchetti, F., Garazzino S., Montagnani C., Dona D., Meini A., Felici E., Vergine G., Bernardi S., Giacchero R., Vecchio A.L., Marchisio P., Nicolini G., Pierantoni L., Rabbone I., Banderali G., Denina M., Venturini E., Krzysztofiak A., Badolato R., Bianchini S., Galli L., Villani A., Castelli-Gattinara G., Salvini F., Abbagnato L., Castagnola E., Dodi I., Ghitti C., Lippi P., Agostiniani R., Cherubini S., Valentini P., Gianino P., Vaccaro A., Manzoni P., Verna P., Comberiati P., Di Filippo P., Gallia P., Battezzati G., Fiore L., Dalmazzo C., Tappi E., Lazzerini M., Tovo P.-A., Scolfaro C., Pruccoli G., Ramenghi U., Giaquinto C., da Dalt L., Tornese G., Berlese P., Plebani A., Manno E.C., Santilli V., Lancella L., Cursi L., Campana A., Bozzola E., Bosis S., Lanari M., Pecoraro C., Del Barba P., Nicastro E., Esposito S., Zuccotti G.V., Corsello G., Cardinale F., Tocco A.M., Ballardini G., Agostoni C., Chiappini E., Indolfi G., Anna B., Cazzato S., Zavarise G., Pignata C., Marchetti F., Garazzino, S., Montagnani, C., Dona, D., Meini, A., Felici, E., Vergine, G., Bernardi, S., Giacchero, R., Vecchio, A. L., Marchisio, P., Nicolini, G., Pierantoni, L., Rabbone, I., Banderali, G., Denina, M., Venturini, E., Krzysztofiak, A., Badolato, R., Bianchini, S., Galli, L., Villani, A., Castelli-Gattinara, G, Tornese, G, Filippo Salvini, Laura Abbagnato, Elio Castagnola, Icilio Dodi, Cesare Ghitti, Paola Lippi, Rino Agostiniani, Simonetta Cherubini, Piero Valentini, Paola Gianino, Angelina Vaccaro, Paolo Manzoni, Paola Verna, Pasquale Comberiati, Paola Di Filippo, Paola Gallia, Gianna Battezzati, Ludovica Fiore, Cristina Dalmazzo, Eleonora Tappi, Marta Lazzerini, PierAngelo Tovo, Carlo Scolfaro, Giulia Pruccoli, Ugo Ramenghi, Carlo Giaquinto, Liviana Da Dalt, Gianluca Tornese, Paola Berlese, Alessandro Plebani, Emma Concetta Manno, Veronica Santilli, Laura Lancella, Laura Cursi, Andrea Campana, Elena Bozzola, Samantha Bosis, Marcello Lanari, Carmine Pecoraro, Paolo Del Barba, Emanuele Nicastro, Silvia Garazzino, Carlotta Montagnani, Daniele Donà, Antonella Meini, Enrico Felici, Gianluca Vergine, Stefania Bernardi, Roberta Giacchero, Andrea Lo Vecchio, Paola Marchisio, Giangiacomo Nicolini, Luca Pierantoni, Ivana Rabbone, Giuseppe Banderali, Marco Denina, Elisabetta Venturini, Andrzej Krzysztofiak , Raffaele Badolato, Sonia Bianchini, Luisa Galli, Alberto Villani , Guido Castelli-Gattinara, Susanna Esposito, Gian Vincenzo Zuccotti, Giovanni Corsello, Fabio Cardinale, Anna Maria Tocco, Giuseppina Ballardini, Carlo Agostoni, Elena Chiappini, Giuseppe Indolfi, Bussolini Anna, Salvatore Cazzato, Giorgio Zavarise, Claudio Pignata, Federico Marchetti, Lo Vecchio, A., and Castelli-Gattinara, G.
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Male ,Pediatrics ,Epidemiology ,Protease Inhibitor ,Comorbidity ,medicine.disease_cause ,Clinical Laboratory Technique ,Severe Acute Respiratory Syndrome ,Disease Outbreaks ,Feces ,0302 clinical medicine ,Settore MED/38 - Pediatria Generale E Specialistica ,COVID-19 Testing ,Retrospective Studie ,Pandemic ,030212 general & internal medicine ,Viral ,Child ,Coronavirus ,Pediatric ,Disease Outbreak ,Coinfection ,Hospitals, Pediatric ,Settore MED/38 ,Hospitals ,Diarrhea ,Treatment Outcome ,SARS-CoV-2 infection ,children ,covid-19 ,hydroxychloroquine ,pneumonia ,Adolescent ,Antiviral Agents ,Betacoronavirus ,COVID-19 ,Child, Preschool ,Chronic Disease ,Clinical Laboratory Techniques ,Coronavirus Infections ,Female ,Fever ,Humans ,Immunocompromised Host ,Infant ,Infant, Newborn ,Italy ,Noninvasive Ventilation ,Pandemics ,Pneumonia, Viral ,Protease Inhibitors ,Retrospective Studies ,SARS-CoV-2 ,medicine.symptom ,Rapid Communication ,Human ,medicine.medical_specialty ,Coronaviru ,03 medical and health sciences ,030225 pediatrics ,Virology ,Intensive care ,medicine ,Preschool ,Antiviral Agent ,Betacoronaviru ,business.industry ,Coronavirus Infection ,Public Health, Environmental and Occupational Health ,Retrospective cohort study ,medicine.disease ,Newborn ,Pneumonia ,Fece ,business - Abstract
Data on features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents are scarce. We report preliminary results of an Italian multicentre study comprising 168 laboratory-confirmed paediatric cases (median: 2.3 years, range: 1 day–17.7 years, 55.9% males), of which 67.9% were hospitalised and 19.6% had comorbidities. Fever was the most common symptom, gastrointestinal manifestations were frequent; two children required intensive care, five had seizures, 49 received experimental treatments and all recovered.
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- 2020
17. The Italian arm of the PREPARE study: an international project to evaluate and license a maternal vaccine against group B streptococcus
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Berardi A., Cassetti T., Creti R., Vocale C., Ambretti S., Sarti M., Facchinetti F., Cose S., van Bijlsma M., van De Beek D., Poyart C., French N., Nielsen M., Musoke P., Davies H., Ovale S., Lugli L., Capretti M. G., Lanari M., Dondi A., Ciccia M., Francavilla R., Lanzoni A., Baroni L., Fornaciari S., Carretto E., Alessandrini C., Lucia G., Perrone S., Calderaro A., Bacchini P., Giugno C., Rota C., Pagano R., Guidi B., Biasucci G., Benenati B., Schiavo R., Piccinini G., Pulvirenti R., Rizzo V., Ancora G., China C., Papa I., Viola L., Pedna M. F., Bua J., Travan L., Busetti M., Santori D., Merazzi D., Papa A., Laura L., Auriti C., Bernaschi P., Vento G., Giordano L., Spanu T., Haass C., Margiotta M. C., Nardella G., De Nittis R., Laforgia N., Loprieno S., Giuseppe L., Moramarco A. M., Tzialla C., Fasolato V., Orlandini S., Decembrino L., Del Campo G., Maiocchi A., Cuttano A., Tuoni C., Barnini S., Carnielli V., Perrone B., Orecchioni F., Visintini F., Arzese A., Heath P., Le Doare K., Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, AII - Infectious diseases, Berardi A., Cassetti T., Creti R., Vocale C., Ambretti S., Sarti M., Facchinetti F., Cose S., van Bijlsma M., van De Beek D., Poyart C., French N., Nielsen M., Musoke P., Davies H., Ovale S., Lugli L., Capretti M.G., Lanari M., Dondi A., Ciccia M., Francavilla R., Lanzoni A., Baroni L., Fornaciari S., Carretto E., Alessandrini C., Lucia G., Perrone S., Calderaro A., Bacchini P., Giugno C., Rota C., Pagano R., Guidi B., Biasucci G., Benenati B., Schiavo R., Piccinini G., Pulvirenti R., Rizzo V., Ancora G., China C., Papa I., Viola L., Pedna M.F., Bua J., Travan L., Busetti M., Santori D., Merazzi D., Papa A., Laura L., Auriti C., Bernaschi P., Vento G., Giordano L., Spanu T., Haass C., Margiotta M.C., Nardella G., De Nittis R., Laforgia N., Loprieno S., Giuseppe L., Moramarco A.M., Tzialla C., Fasolato V., Orlandini S., Decembrino L., Del Campo G., Maiocchi A., Cuttano A., Tuoni C., Barnini S., Carnielli V., Perrone B., Orecchioni F., Visintini F., Arzese A., Heath P., and Le Doare K.
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0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Group B streptococcus ,Sepsi ,International Cooperation ,030106 microbiology ,Disease ,Abortion ,Group B ,Streptococcus agalactiae ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Streptococcal Infections ,medicine ,Humans ,Meningitis ,030212 general & internal medicine ,Newborn ,Prevention ,Vaccine ,Pregnancy Complications, Infectious ,Antibiotic prophylaxis ,reproductive and urinary physiology ,Group B streptococcu ,business.industry ,Streptococcal Vaccines ,Infant, Newborn ,lcsh:RJ1-570 ,lcsh:Pediatrics ,Antibiotic Prophylaxis ,medicine.disease ,Infectious Disease Transmission, Vertical ,Meningiti ,Pneumonia ,Italy ,Immunization ,Commentary ,Female ,business - Abstract
Background Group B streptococcus (GBS) is a leading cause of sepsis, pneumonia and meningitis in infants, with long term neurodevelopmental sequelae. GBS may be associated with poor pregnancy outcomes, including spontaneous abortion, stillbirth and preterm birth. Intrapartum antibiotic prophylaxis (IAP) is currently the only way to prevent early-onset disease (presenting at 0 to 6 days of life), although it has no impact on the disease presenting over 6 days of life and its implementation is challenging in resource poor countries. A maternal vaccine against GBS could reduce all GBS manifestations as well as improve pregnancy outcomes, even in low-income countries. Main body The term “PREPARE” designates an international project aimed at developing a maternal vaccination platform to test vaccines against neonatal GBS infections by maternal immunization. It is a non-profit, multi-center, interventional and experimental study (promoted by the St George University of London. [UK]) with the aim of developing a maternal vaccination platform, determining pregnancy outcomes, and defining the extent of GBS infections in children and mothers in Africa. PREPARE also aims to estimate the protective serocorrelates against the main GBS serotypes that cause diseases in Europe and Africa and to conduct two trials on candidate GBS vaccines. PREPARE consists of 6 work packages. In four European countries (Italy, UK, Netherlands, France) the recruitment of cases and controls will start in 2020 and will end in 2022. The Italian PREPARE network includes 41 centers. The Italian network aims to collect: GBS isolates from infants with invasive disease, maternal and neonatal sera (cases); cord sera and GBS strains from colonized mothers whose infants do not develop GBS infection (controls). Short conclusion PREPARE will contribute information on protective serocorrelates against the main GBS serotypes that cause diseases in Europe and Africa. The vaccine that will be tested by the PREPARE study could be an effective strategy to prevent GBS disease.
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- 2020
18. Atherosclerosis precursors in children. The Bologna study, an update
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Faldella, G., Alati, S., Alessandroni, R., Rossini, R., Lanari, M., Colucci, C., Salvioli, G. P., Descovich, Giancarlo, editor, Gaddi, Antonio, editor, Magri, Gianluigi, editor, and Lenzi, Sergio, editor
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- 1990
- Full Text
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19. Gestione del Covid-19 in età pediatrica: documento di consenso [Management of Covid-19 in the Paediatric Age: Consensus Document]
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Esposito, S., Marchetti, F., Lanari, M., Caramelli, F., Fanti, A. D., Vergine, G., Iughetti, L., Fornaro, M., Suppiej, A., Zona, S., Pession, A., and Biasucci, G.
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Covid-19 ,Children ,Prevention ,Consensus document ,Socio-culturale - Published
- 2021
20. Role of respiratory pathogens in infants hospitalized for a first episode of wheezing and their impact on recurrences
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Bosis, S., Esposito, S., Niesters, H.G.M., Zuccotti, G.V., Marseglia, G., Lanari, M., Zuin, G., Pelucchi, C., Osterhaus, A.D.M.E., and Principi, N.
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- 2008
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21. Children and SARS-CoV-2 infection: innocent bystanders…until proven otherwise
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Lanari, M., Chiereghin, A., Biserni, G.B., Rocca, A., Re, M.C., and Lazzarotto, T.
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- 2020
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22. Clinical relevance of prevention of respiratory syncytial virus lower respiratory tract infection in preterm infants born between 33 and 35 weeks gestational age
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Carbonell-Estrany, X., Bont, L., Doering, G., Gouyon, J-B., and Lanari, M.
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- 2008
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23. Chilblains in a child with confirmed SARS‐CoV‐2 infection: a red flag for late‐onset skin manifestation in previously infected individuals
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Neri, I., primary, Conti, F., additional, Virdi, A., additional, Guglielmo, A., additional, Leonardi, L., additional, Corsini, I., additional, Ghizzi, C., additional, Gabrielli, L., additional, Lazzarotto, T., additional, Lanari, M., additional, Patrizi, A., additional, and Misciali, C., additional
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- 2021
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24. Pediatric urticaria in the Emergency Department: epidemiological characteristics and predictive factors for its persistence in children
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Talarico, V., primary, Marseglia, G.L., additional, Lanari, M., additional, Esposito, S., additional, Masi, S., additional, De Filippo, M., additional, Gallelli, L., additional, Licari, A., additional, Lubrano, R., additional, and Zampogna, S., additional
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- 2021
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25. Resting respiratory lung volumes are 'healthier' than exercise respiratory volumes in different types of palliated or corrected congenital heart disease
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Fabi M., Balducci A., Cazzato S., Aceti A., Gallucci M., Di Palmo E., Gargiulo G., Donti A., and Lanari M.
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complete respiratory function ,cardiopulmonary exercise tests ,congenital heart disease ,cardiac surgery - Abstract
Aims: Cardiac surgery has improved life expectancy of patients with congenital heart diseases (CHDs). Exercise capacity is an important determinant of survival in patients with CHDs. There is a lack of studies focusing on the role of resting respiratory performance in reducing exercise tolerance in these patients. Objectives: To determine the prevalence and severity of respiratory functional impairment in different types of corrected/palliated CHDs, and its impact on an exercise test. Materials and Methods: Retrospective single-center study involving 168 corrected/palliated patients with CHD and 52 controls. Patients CHD were divided into subgroups according to the presence of native pulmonary blood flow or total cavopulmonary connection (TCPC). All subjects performed complete pulmonary function tests and gas diffusion; patients with CHD also performed cardiopulmonary exercise test (CPX). Results: Mean values of lung volumes were within the normal range in all CHD groups. Comparing to controls, patients with the reduced pulmonary flow and with TCPC had the highest reduction in lung volumes. CPX was reduced in all groups, most severely in TCPC, and it was correlated to decreased dynamic volumes in all CHD groups except in TCPC. Younger age at intervention and number of surgical operations negatively affected lung volumes. Conclusions: Respiratory function is within the normal range in our patients with different CHDs at rest but altered in all CHDs during exercise when cardiorespiratory balance is likely to be inadequate. Comparing the different groups, patients with reduced pulmonary flow and TCPC are the most impaired.
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- 2020
26. Children and coronavirus: The necessary search for a balance between the alleged risks and documented collateral damage
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Tamburlini, G., Marchetti, F., Bertino, E., Bestetti, G., Biasucci, G., Biondi, A., Bonati, M., Brunelli, A., Corsello, G., Esposito, S., Fagioli, F., Farina, D., Gagliardi, L., Gangemi, M., Greco, L., Lanari, M., Lazzerini, M., Maggiore, G., Martelossi, S., Ramenghi, U., Piga, A., Selicorni, A., Spada, M., Ventura, A., Vicari, S., Zampino, G., and Zanetto, F.
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- 2020
27. Duck‐like lips: a new clinical feature for diagnosis of Mycoplasma‐Induced Rash and Mucositis
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Dondi, A., primary, Di Altobrando, A., additional, Parladori, R., additional, Biagi, C., additional, Balsamo, C., additional, Ghizzi, C., additional, Patrizi, A., additional, Lanari, M., additional, and Neri, I., additional
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- 2020
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28. Acral skin eruption observed during SARS‐CoV‐2 pandemic: possible keratolysis exfoliativa with red palms and soles
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Neri, I., primary, Patrizi, A., additional, Gabrielli, L., additional, Virdi, A., additional, Veronesi, G., additional, Corsini, I., additional, Lazzarotto, T., additional, Lanari, M., additional, Misciali, C., additional, and Guglielmo, A., additional
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- 2020
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29. The Imola Active Breaks study: a new strategy in child public health to reduce sedentary
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Masini, A, primary, Marini, S, additional, Gori, D, additional, Montalti, M, additional, Lanari, M, additional, Ceciliani, A, additional, Stagni, R, additional, Bisi, M C, additional, Tessari, A, additional, and Dallolio, L, additional
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- 2020
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30. Major cluster of paediatric ‘true’ primary chilblains during the COVID‐19 pandemic: a consequence of lifestyle changes due to lockdown
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Neri, I., primary, Virdi, A., additional, Corsini, I., additional, Guglielmo, A., additional, Lazzarotto, T., additional, Gabrielli, L., additional, Misciali, C., additional, Patrizi, A., additional, and Lanari, M., additional
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- 2020
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31. Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies
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Lanari, M., primary, Anderson, E.J., additional, Sheridan-Pereira, M., additional, Carbonell-Estrany, X., additional, Paes, B., additional, Rodgers-Gray, B.S., additional, Fullarton, J. R., additional, Grubb, E., additional, and Blanken, M., additional
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- 2020
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32. Complications and risk factors for severe outcome in children with measles
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Lo Vecchio, A, Krzysztofiak, A, Montagnani, C, Valentini, Piero, Rossi, N, Garazzino, S, Raffaldi, I, Di Gangi, M, Esposito, S, Vecchi, B, Melzi, Ml, Lanari, M, Zavarise, G, Bosis, S, Valenzise, M, Cazzato, S, Sacco, Monica, Govoni, Mr, Mozzo, E, Cambriglia, Md, Bruzzese, E, Di Camillo, C, Pata, Davide, Graziosi, A, Sala, D, Magurano, F, Villani, A, Guarino, A, Galli, L, SITIP Measles Study, Group., Lo Vecchio, A, Krzysztofiak, A, Montagnani, C, Valentini, P, Rossi, N, Garazzino, S, Raffaldi, I, Di Gangi, M, Esposito, S, Vecchi, B, Melzi, Ml, Lanari, M, Zavarise, G, Bosis, S, Valenzise, M, Cazzato, S, Sacco, M, Govoni, Mr, Mozzo, E, Cambriglia, Md, Bruzzese, E, Di Camillo, C, Pata, D, Graziosi, A, Sala, D, Magurano, F, Villani, A, Guarino, A, Galli, L, Lo Vecchio, Andrea, Krzysztofiak, Andrzej, Montagnani, Carlotta, Valentini, Piero, Rossi, Nadia, Garazzino, Silvia, Raffaldi, Irene, Di Gangi, Maria, Esposito, Susanna, Vecchi, Barbara, Melzi, Maria Luisa, Lanari, Marcello, Zavarise, Giorgio, Bosis, Samantha, Valenzise, Mariella, Cazzato, Salvatore, Sacco, Michele, Govoni, Maria Rita, Mozzo, Elena, Cambriglia, Maria Donata, Bruzzese, Eugenia, Di Camillo, Chiara, Pata, Davide, Graziosi, Alessandro, Sala, Debora, Magurano, Fabio, Villani, Alberto, Guarino, Alfredo, and Galli, Luisa
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Male ,Pediatrics ,medicine.medical_specialty ,Neutropenia ,genotype ,severe outcome ,complication ,Intensive Care Units, Pediatric ,Measles ,Severity of Illness Index ,children ,measles ,Risk Factors ,Intensive care ,medicine ,measle ,Humans ,Viral ,Encephalitis, Viral ,Preschool ,Child ,Pediatric ,biology ,Receiver operating characteristic ,business.industry ,C-reactive protein ,Child, Preschool ,Female ,Infant ,Italy ,Measles virus ,Pancreatitis ,ROC Curve ,Retrospective cohort study ,medicine.disease ,Settore MED/38 ,Intensive Care Units ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Pediatrics, Perinatology and Child Health ,biology.protein ,Encephalitis ,Complication ,business - Abstract
Objective and designRisk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.ResultsNineteen hospitals enrolled 249 children (median age 14.5 months): 207 (83%) children developed a complication and 3 (1%) died. Neutropaenia was more commonly reported in children with B3-genotype compared with other genotypes (29.5% vs 7.7%, p=0.01). Pancreatitis (adjusted OR [aOR] 9.19, p=0.01) and encephalitis (aOR 7.02, p=0.04) were related to severe outcome in multivariable analysis, as well as C reactive protein (CRP) (aOR 1.1, p=0.028), the increase of which predicted severe outcome (area under the receiver operating characteristic curve 0.67, 95% CI 0.52 to 0.82). CRP values >2 mg/dL were related to higher risk of complications (OR 2.0, 95% CI 1.15 to 3.7, p=0.01) or severe outcome (OR 4.13, 95% CI 1.43 to 11.8, pConclusionThe risk of severe outcome in measles is independent of age and underlying conditions, but is related to the development of organ complications and may be predicted by CRP value.
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- 2018
33. High risk of nosocomial-acquired RSV infection in children with congenital heart disease
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Lanari, M., Rossi, G. A., Merolla, R., and di Luzio Paparatti, U.
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- 2004
34. Iron balance and iron nutrition in infancy
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Faldella, G, Corvaglia, L, Lanari, M, and Salvioli, G P
- Published
- 2003
35. Strategies for preventing group B streptococcal infections in newborns: A nation-wide survey of Italian policies
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Tzialla, C, berardi, A, farina, C, clerici, P, borghesi, A, viora, E, scollo, P, stronati, M, Task Force for group B streptococcal infections for the Italian Society of Neonatology including Stival, G, barbaglia, Ma, guala, A, giunta, E, parola, L, grossignani, Mr, perri, P, tubaldi, L, alletto, G, daidone, S, flacco, V, dani, C, sterpa, A, rapisardi, G, elicio, Mr, faldella, G, capretti, Mg, messner, H, bandiera, M, achille, C, azzali, A, montrasio, G, mariani, S, galvagno, G, giacosa, E, de Angelis, F, spandrio, M, serra, A, garofalo, F, perona, A, porcelli, F, ferrero, F, De Franco, S, paollilo, P, picone, S, besana, R, varisco, T, farina, M, memo, L, nicolini, G, lietti, D, Di Chiara, G, rottoli, A, Bonabitacola, T, Cortis, E, Neri, E, Martinelli, S, Ilardi, L, Rondanini, Gf, Calzi, P, Gatta, A, Quntadamo, Pa, Ivaldi, M, Terenzani, L, Di Lascio, N, Travaglio, Md, Vetrano, G, Furcolo, G, Vitacco, V, Intini, C, Frigerio, M, Stroppiana, P, Policicchio, G, Mesirca, P, Gianino, P, Audenio, E, Paludetto, R, Raimondi, F, Pugliese, A, Valentino, L, Nosari, N, Marchesano, G, Chirico, G, Bellù, R, Menchini, M, Poletti, A, E T, Vacchiano, Pinto, L, E D, Perri, Coppola, R, Perini, R, Vetrella, A, De Luca, G, Lista, G, Cavigioli, F, Bettinelli, A, Massironi, E, Franco, C, Bernardo, L, Poli, S, Palladini, M, Tota, V, Spadavecchia, F, Zuccotti, Gv, Pogliani, L, Bracaglia, G, Mancini, Al, Zocco, F, Iozzia, G, Auriemma, A, Teani, M, Mangilli, G, Tempra, Am, Di Terlizi, L, Bottino, R, Salvi, C, Fortunato, V, Musaico, R, Gargantini, G, Carrera, G, Magaldi, R, Taurino, L, D'Onofrio, Am, Buffone, E, Tempera, A, Agosti, M, Garzia, P, Mosca, F, Pugni, L, Tagliabue, P, Colombo, C, Demi, M, Picco, G, Carlucci, A, Zorzi, G, Padula, D, Cardone, Ml, Buonocore, G, Muraca, Mc, Boldrini, A, Ciantelli, M, Lanari, M, Serra, L, Felici, L, Banderalli, G, Brambilla, C, Dall'Agnola, A, Viviani, E, Zonca, Mc, Licardi, G, Chiara, A, Ancora, G, Papa, I, Gancia, P, Pomero, G, Deloglu, A, Villani, P, Mussini, P, Canidio, E, Migliavacca, D, Di Fabio, S, Cipollone, I, Biasucci, G, Rubbi, P, Piepoli, M, Guastaferro, N, Infriccioli, F, Bertino, E, Perathoner, C, Parmigiani, S, Suriano, G, Ianniello, C, Biasini, A, Azzalli, M, Timpani, G, Barresi, S, Caoci, G, Ciccotti, R, De Curtis, M, Natale, F, Finocchi, M, Haass, C, Milillo, F, Lucieri, S, Guercio, E, Canepa, Sa, Scozia, G, Antonucci, R, Limongelli, O, Macciò, S, Mongelli, F, Colonna, F, Dragovic, D, Calipa, Mt, Cohen, A, Moresco, L, Italian Society of Obstetricians and Gynecologists including La Spina, R, Ruggeri, R, Luehwink, A, Brattoli, M, Fedi, A, Lacchi, L, Ettore, G, Pappalardo, E, Conoscenti, G, Zeni, B, Spellecchia, D, Favretti, L, Spagna, L, Zaglio, S, Bresciani, D, Bandini, A, Mancini, R, Mustoni, P, Dodero, D, Grimaldi, M, Di Mario, M, Migliorini, P, Kemeny, A, Anastasio, Ps, Riccardi, T, Maggino, T, Cerri, G, Puggina, P, Marconi, Am, Morgia, S, Bellia, G, D'Anna, Mr, Catania, M, Bacchi Modena, A, Franchi, L, Calonaci, N, Schettini, S, Paradiso, R, Saccucci, P, Ioppi, M, Zorzi, M, Stellin, G, Patacchiola, F, Carrata, L, Bassini, D, San Marco, L, Todros, T, Tibadi, C, Liborio, M, Italian Association of Clinical Microbiologists including Laricchia, R, Tauro, L, Ferrara, F, Nuara, C, Ghiraldi, E, Molinari, F, Comessatti, A, Rocchetti, A, Di Matteo, L, Miconi, V, Calvi, P, Pernigotti, A, Fabozzi, F, Micca, G, Monticone, G, Sarti, M, Da Rin, G, Zoppelletto, M, Modolo, E, Landini, Mp, Furlini, G, Galluppi, E, Pagani, E, Aschbacher, R, Innocenti, P, Bresolin, N, Raggi, Me, Bonfanti, C, De Francesco, M, Santer, P, Griessmaier, A, De Francesco, D, Pirali, A, Prasciolu, C, Usai, F, Cuzzone, G, Scutellà, M, Tramacere, P, Fossati, D, Piaserico, G, Bordignon, G, Sciacca, A, Di Vincenzo, F, Imbriani, A, Melotti, D, Catanoso, G, Rivetti, I, Neri, G, Bruno, R, Bacelle, L, Sartore, P, Giana, G, Sala, E, Giraldi, C, Cavalcanti, P, Perugini, M, Perugini, A, Ginardi, C, Maritano, D, Ferrini, A, Bonettini, A, Avanzini, A, Gasperoni, S, Pieretti, B, Montanari, E, Carillo, C, Rossi, Mr, Laureti, A, Baldoni, Ml, Serra, D, Melioli, G, Bandettini, R, Oneto, F, Colla, R, Storchi Incerti, S, Lanzini, F, Pauri, P, Tili, E, Leone, Ra, Verdastro, G, Megha, M, Luzzaro, F, Conti, A, Busulini, L, Mirri, P, Diodati, R, Vettori, C, Pittalis, S, Anesi, A, Fiore, A, Goglia, L, Vitullo, E, Sinno, A, Platzgummer, S, Spitaler, C, Trabucchi, Mc, Besozzi, M, Cesana, E, Inghilleri, G, Grosso, S, D'Angelo, R, Fogato, E, Lavarda, F, Ortisi, G, Clementi, M, Cichero, P, Rumpianesi, F, Venturelli, C, Mortillaro, F, Daffara, S, Catania, Mr, Iula, D, Andreoni, S, Politi, A, Agostinelli, C, Paparella, C, Capozzi, D, Notaris, P, Bistoni, F, Mencacci, A, Valentini, M, Filippetti, A, Confalonieri, M, Novarese, O, Bonini, F, Salamone, D, Camporese, A, De Rosa, R, Casprini, P, Degl'Innocenti, R, Giordano, R, Allù, Mt, Zanella, D, Malandrino, M, Tronci, M, Valmarin, M, Leonetti, G, Falco, S, Meledandri, M, Ballardini, M, Spanò, A, Cava, Mc, Mascellino, Mt, Schinella, M, Gualdi, P, Casari, E, Scattolo, N, Motta, C, Perfetti, C, Bassano, M, Cera, G, Iafisco, P, Mura, I, Palmieri, A, Migliardi, M, Ferlini, M, Grandi, G, Giardini, F, Albano, F, Latino, M, Ferrero, Mp, Bellizia, L, Russolo, M, Russolo, S, Pesenti, A, Fasano, Ma, Previato, S, Radillo, O, Busetti, M, Ferrari, P, Siderini, V, Puzzolante, L, Scarparo, C, Arzese, A, Cappuccia, N, Lodolo, L, Delledonne, L, Gramoni, A, Maiolo, V, Gheller, A, Spadaro, S, Balzaretti, M, Tzialla, C., Berardi, A., Farina, C., Clerici, P., Borghesi, A., Viora, E., Scollo, P., Stronati, M., Stival, G., Barbaglia, M. A., Guala, A., Giunta, E., Parola, L., Grossignani, M. R., Perri, P., Tubaldi, L., Alletto, G., Daidone, S., Flacco, V., Dani, C., Sterpa, A., Rapisardi, G., Elicio, M. R., Faldella, G., Capretti, M. G., Messner, H., Bandiera, M., Achille, C., Azzali, A., Montrasio, G., Mariani, S., Galvagno, G., Giacosa, E., de Angelis, F., Spandrio, M., Serra, A., Garofalo, F., Perona, A., Porcelli, F., Ferrero, F., De Franco, S., Paollilo, P., Picone, S., Besana, R., Varisco, T., Farina, M., Memo, L., Nicolini, G., Lietti, D., Di Chiara, G., Rottoli, A., Bonabitacola, T., Cortis, E., Neri, E., Martinelli, S., Ilardi, L., Rondanini, G. F., Calzi, P., Gatta, A., Quntadamo, P. A., Ivaldi, M., Terenzani, L., Di Lascio, N., Travaglio, M. D., Vetrano, G., Furcolo, G., Vitacco, V., Intini, C., Frigerio, M., Stroppiana, P., Policicchio, G., Mesirca, P., Gianino, P., Audenio, E., Paludetto, R., Raimondi, F., Pugliese, A., Valentino, L., Nosari, N., Marchesano, G., Chirico, G., Bell(`u), R., Menchini, M., Poletti, A., Vacchiano, T., Pinto, L., Perri, D., Coppola, R., Perini, R., Vetrella, A., De Luca, G., Lista, G., Cavigioli, F., Bettinelli, A., Massironi, E., Franco, C., Bernardo, L., Poli, S., Palladini, M., Tota, V., Spadavecchia, F., Zuccotti, G. V., Pogliani, L., Bracaglia, G., Mancini, A. L., Zocco, F., Iozzia, G., Auriemma, A., Teani, M., Mangilli, G., Tempra, A. M., Di Terlizi, L., Bottino, R., Salvi, C., Fortunato, V., Musaico, R., Gargantini, G., Carrera, G., Magaldi, R., Taurino, L., D?onofrio, A. M., Buffone, E., Tempera, A., Agosti, M., Garzia, P., Mosca, F., Pugni, L., Tagliabue, P., Colombo, C., Demi, M., Picco, G., Carlucci, A., Zorzi, G., Padula, D., Cardone, M. L., Buonocore, G., Muraca, M. C., Boldrini, A., Ciantelli, M., Lanari, M., Serra, L., Felici, L., Banderalli, G., Brambilla, C., Dall?agnola, A., Viviani, E., Zonca, M. C., Licardi, G., Chiara, A., Ancora, G., Papa, I., Gancia, P., Pomero, G., Deloglu, A., Villani, P., Mussini, P., Canidio, E., Migliavacca, D., Di Fabio, S., Cipollone, I., Biasucci, G., Rubbi, P., Piepoli, M., Guastaferro, N., Infriccioli, F., Bertino, E., Perathoner, C., Parmigiani, S., Suriano, G., Ianniello, C., Biasini, A., Azzalli, M., Timpani, G., Barresi, S., Caoci, G., Ciccotti, R., De Curtis, M., Natale, F., Finocchi, M., Haass, C., Milillo, F., Lucieri, S., Guercio, E., Canepa, S. A., Scozia, G., Antonucci, R., Limongelli, O., Macci(`o), S., Mongelli, F., Colonna, F., Dragovic, D., Calipa, M. T., Cohen, A., Moresco, L., La Spina, R., Ruggeri, R., Luehwink, A., Brattoli, M., Fedi, A., Lacchi, L., Ettore, G., Pappalardo, E., Conoscenti, G., Zeni, B., Spellecchia, D., Favretti, L., Spagna, L., Zaglio, S., Bresciani, D., Bandini, A., Mancini, R., Mustoni, P., Dodero, D., Grimaldi, M., Di Mario, M., Migliorini, P., Kemeny, A., Anastasio, P. S., Riccardi, T., Maggino, T., Cerri, G., Puggina, P., Marconi, A. M., Morgia, S., Bellia, G., D?anna, M. R., Catania, M., Bacchi Modena, A., Franchi, L., Calonaci, N., Schettini, S., Paradiso, R., Saccucci, P., Ioppi, M., Zorzi, M., Stellin, G., Patacchiola, F., Carrata, L., Bassini, D., San Marco, L., Todros, T., Tibadi, C., Liborio, M., Laricchia, R., Tauro, L., Ferrara, F., Nuara, C., Ghiraldi, E., Molinari, F., Comessatti, A., Rocchetti, A., Di Matteo, L., Miconi, V., Calvi, P., Pernigotti, A., Fabozzi, F., Micca, G., Monticone, G., Sarti, M., Da Rin, G., Zoppelletto, M., Modolo, E., Landini, M. P., Furlini, G., Galluppi, E., Pagani, E., Aschbacher, R., Innocenti, P., Bresolin, N., Raggi, M. E., Bonfanti, C., De Francesco, M., Santer, P., Griessmaier, A., De Francesco, D., Pirali, A., Prasciolu, C., Usai, F., Cuzzone, G., Scutell(`a), M., Tramacere, P., Fossati, D., Piaserico, G., Bordignon, G., Sciacca, A., Di Vincenzo, F., Imbriani, A., Melotti, D., Catanoso, G., Rivetti, I., Neri, G., Bruno, R., Bacelle, L., Sartore, P., Giana, G., Sala, E., Giraldi, C., Cavalcanti, P., Perugini, M., Perugini, A., Ginardi, C., Maritano, D., Ferrini, A., Bonettini, A., Avanzini, A., Gasperoni, S., Pieretti, B., Montanari, E., Carillo, C., Rossi, M. R., Laureti, A., Baldoni, M. L., Serra, D., Melioli, G., Bandettini, R., Oneto, F., Colla, R., Storchi Incerti, S., Lanzini, F., Pauri, P., Tili, E., Leone, R. A., Verdastro, G., Megha, M., Luzzaro, F., Conti, A., Busulini, L., Mirri, P., Diodati, R., Vettori, C., Pittalis, S., Anesi, A., Fiore, A., Goglia, L., Vitullo, E., Sinno, A., Platzgummer, S., Spitaler, C., Trabucchi, M. C., Besozzi, M., Cesana, E., Inghilleri, G., Grosso, S., D?angelo, R., Fogato, E., Lavarda, F., Ortisi, G., Clementi, M., Cichero, P., Rumpianesi, F., Venturelli, C., Mortillaro, F., Daffara, S., Catania, M. R., Iula, D., Andreoni, S., Politi, A., Agostinelli, C., Paparella, C., Capozzi, D., Notaris, P., Bistoni, F., Mencacci, A., Valentini, M., Filippetti, A., Confalonieri, M., Novarese, O., Bonini, F., Salamone, D., Camporese, A., De Rosa, R., Casprini, P., Degl?innocenti, R., Giordano, R., All(`u), M. T., Zanella, D., Malandrino, M., Tronci, M., Valmarin, M., Leonetti, G., Falco, S., Meledandri, M., Ballardini, M., Span(`o), A., Cava, M. C., Mascellino, M. T., Schinella, M., Gualdi, P., Casari, E., Scattolo, N., Motta, C., Perfetti, C., Bassano, M., Cera, G., Iafisco, P., Mura, I., Palmieri, A., Migliardi, M., Ferlini, M., Grandi, G., Giardini, F., Albano, F., Latino, M., Ferrero, M. P., Bellizia, L., Russolo, M., Russolo, S., Pesenti, A., Fasano, M. A., Previato, S., Radillo, O., Busetti, M., Ferrari, P., Siderini, V., Puzzolante, L., Scarparo, C., Arzese, A., Cappuccia, N., Lodolo, L., Delledonne, L., Gramoni, A., Maiolo, V., Gheller, A., Spadaro, S., Balzaretti, M., Tzialla, Chryssoula, Berardi, Alberto, Farina, Claudio, Clerici, Pierangelo, Borghesi, Alessandro, Viora, Elsa, Scollo, Paolo, Stronati, Mauro, [.., Lanari, Marcello, Faldella, Giacomo, and ]
- Subjects
Male ,Pediatrics ,Group B ,0302 clinical medicine ,Neonate ,Pregnancy ,Surveys and Questionnaires ,Prevalence ,Mass Screening ,Blood culture ,030212 general & internal medicine ,Antibiotic prophylaxis ,Survey ,GBS ,Group B streptococcus ,Infection ,Newborn infant ,Adult ,Antibiotic Prophylaxis ,Female ,Health Surveys ,Humans ,Infant, Newborn ,Italy ,Neonatal Screening ,Pregnancy Complications, Infectious ,Prenatal Care ,Primary Prevention ,Risk Assessment ,Streptococcal Infections ,Streptococcus agalactiae ,reproductive and urinary physiology ,Group B streptococcu ,medicine.diagnostic_test ,lcsh:RJ1-570 ,Infectious ,Perinatology and Child Health ,Pediatrics, Perinatology and Child Health ,medicine.medical_specialty ,Antibiotic sensitivity ,Group B Streptococcal Infection ,Prenatal care ,03 medical and health sciences ,030225 pediatrics ,medicine ,Intensive care medicine ,Mass screening ,business.industry ,Public health ,Infant ,lcsh:Pediatrics ,Newborn ,Pregnancy Complications ,business - Abstract
Background There are no Italian data regarding the strategies for preventing neonatal group B streptococcal (GBS) infection. We conducted a national survey in order to explore obstetrical, neonatal and microbiological practices for the GBS prevention. Methods Three distinct questionnaires were sent to obstetricians, neonatologists and microbiologists. Questionnaires included data on prenatal GBS screening, maternal risk factors, intrapartum antibiotic prophylaxis, microbiological information concerning specimen processing and GBS antimicrobial susceptibility. Results All respondent obstetrical units used the culture-based screening approach to identify women who should receive intrapartum antibiotic prophylaxis, and more than half of the microbiological laboratories (58%) reported using specimen processing consistent with CDC guidelines. Most neonatal units (89 out of 107, 82%) reported using protocols for preventing GBS early-onset sepsis consistent with CDC guidelines. Conclusions The screening-based strategy is largely prevalent in Italy, and most protocols for preventing GBS early-onset sepsis are consistent with CDC guidelines. However, we found discrepancies in practices among centers that may reflect the lack of Italian guidelines issued by public health organizations.
- Published
- 2017
36. Studio multidisciplinare per la valutazione delle deformazioni del suolo connesse alle attività di produzione di idrocarburi in aree dell'offshore emiliano romagnolo finalizzato allo sviluppo di un modello per il monitoraggio integrato
- Author
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I. Antoncecchi, G. Rossi, F. Ciccone, E. Carminati, A. Morelli, G. Pezzo, P. Macini, S. Gandolfi, R. Lanari, M. Manzo and F. Moia, F. Verga, L. Perini, P. Severi, L. Petracchini, F. Terlizzese
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offshore ,modello integrato ,deformazione del suolo ,idrocarburi - Abstract
La DGS UNMIG ha promosso, nell'ambito della rete di ricerca CLYPEA "il network per la sicurezza offshore", uno studio multidisciplinare per la valutazione delle deformazioni del suolo connesse ad attività di produzione di idrocarburi in aree marino-costiere dell'offshore emiliano-romagnolo finalizzato allo sviluppo di un modello per il monitoraggio integrato. L'iniziativa nasce nel 2016 a seguito dell'accordo siglato ad Ottobre tra il Ministero Sviluppo Economico e la Regione Emilia Romagna (accordo offshore), con l'intento di verificare una possibile estensione a mare degli "Indirizzi e Linee Guida per il monitoraggio della sismicità, delle deformazioni del suolo e delle pressioni di poro" (ILG, 2014). Il progetto "subsidenza" si pone l'obiettivo di affrontare il tema del monitoraggio e controllo della subsidenza in mare che, già da diversi anni, rappresenta un elemento chiave per il mantenimento di elevati standard di sicurezza nelle operazioni di produzione di idrocarburi integrando le competenze di 6 enti specializzati (tra università e centri di ricerca). Di seguito si riportano i diversi contributi alle attività che contribuiranno al raggiungimento degli obiettivi del progetto.
- Published
- 2018
37. Risk factors for bronchiolitis hospitalization during the first year of life in a multicenter Italian birth cohort
- Author
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Lanari M, Prinelli F, Adorni F, Di Santo S, Vandini S, Silvestri M, Musicco M, Faldella G, Spinelli M, Corsello G, Gabriele B, La Forgia N, Loprieno S, Boldrini A, Vuerich M, Del Vecchio A, Bertino E, Fabris C, Coscia A, Fanos V, Puddu M, Gargano G, Braibanti S, Corso G, Orfeo L, De Luca MG, Paolillo P, Fabiano A, Barberi I, Arco A, Barboni G, Molinari L, Bonomi A, Ladetto L, Carlucci A, Zorzi G, Dall’Agnola A, Girardi E, Di Fabio S, Faccia P, Bottau P, Macagno F, Ellero S, Magaldi R, Rinaldi M, Memo L, Nicolini G, Ngalikpima CJ, Nosari N, Sarnelli P, Parmigiani S, Agosti M, Negri C, Corona MF, Piano F, Scarcella A, Umbaldo A, De Curtis M, Natale F, Aurilia C, Romagnoli C, Lanari, Marcello, Prinelli, Federica, Adorni, Fulvio, Di Santo, Simona, Vandini, Silvia, Silvestri, Michela, Musicco, Massimo, and Lanari M, Prinelli F, Adorni F, Di Santo S, Vandini S, Silvestri M, Musicco M, Faldella G, Spinelli M, Corsello G, Gabriele B, La Forgia N, Loprieno S, Boldrini A, Vuerich M, Del Vecchio A, Bertino E, Fabris C, Coscia A, Fanos V, Puddu M, Gargano G, Braibanti S, Corso G, Orfeo L, De Luca MG, Paolillo P, Fabiano A, Barberi I, Arco A, Barboni G, Molinari L, Bonomi A, Ladetto L, Carlucci A, Zorzi G, Dall’Agnola A, Girardi E, Di Fabio S, Faccia P, Bottau P, Macagno F, Ellero S, Magaldi R, Rinaldi M, Memo L, Nicolini G, Ngalikpima CJ, Nosari N, Sarnelli P, Parmigiani S, Agosti M, Negri C, Corona MF, Piano F, Scarcella A, Umbaldo A, De Curtis M, Natale F, Aurilia C, Romagnoli C
- Subjects
Palivizumab ,Male ,Pediatrics ,medicine.medical_specialty ,Multivariate analysis ,Gestational Age ,Respiratory Syncytial Virus Infections ,Respiratory syncytial virus ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Risk Factors ,030225 pediatrics ,medicine ,Bronchiolitis, Viral ,Humans ,030212 general & internal medicine ,Bronchiolitis ,Children ,Hospitalization ,Prophylaxis ,Risk factor ,Breast Feeding ,Crowding ,Female ,Infant ,Infant, Newborn ,Italy ,Multivariate Analysis ,Pediatrics, Perinatology and Child Health ,Viral ,Bronchiolitis, Hospitalization, Risk factor, Respiratory syncytial virus, Prophylaxis, Palivizumab, Children ,business.industry ,Research ,Gestational age ,Perinatology and Child Health ,medicine.disease ,Newborn ,3. Good health ,Gestation ,business ,Breast feeding ,medicine.drug ,Cohort study - Abstract
Background: Respiratory Syncytial Virus (RSV) is one of the main causes of respiratory infections during the first year of life. Very premature infants may contract more severe diseases and 'late preterm infants' may also be more susceptible to the infection. The aim of this study is to evaluate the risk factors for hospitalization during the first year of life in children born at different gestational ages in Italy. Methods: A cohort of 33-34 weeks gestational age (wGA) newborns matched by sex and age with two cohort of newborns born at 35-37 wGA and >37 wGA were enrolled in this study for a three-year period (2009-2012). Hospitalization for bronchiolitis (ICD-9 code 466.1) during the first year of life was assessed through phone interview at the end of the RSV season (November-March) and at the completion of the first year of life. Results: The study enrolled 2314 newborns, of which 2210 (95.5 %) had a one year follow-up and were included in the analysis; 120 (5.4 %) were hospitalized during the first year of life for bronchiolitis. Children born at 33-34 wGA had a higher hospitalization rate compared to the two other groups. The multivariate analysis carried out on the entire population associated the following factors with higher rates for bronchiolitis hospitalization: male gender; prenatal treatment with corticosteroids; prenatal exposure to maternal smoking; singleton delivery; respiratory diseases in neonatal period; surfactant therapy; lack of breastfeeding; siblings
- Published
- 2015
38. Prenatal tobacco smoke exposure increases hospitalizations for bronchiolitis in infants
- Author
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Lanari M, Vandini S, Adorni F, Prinelli F, Di Santo S, Silvestri M, Musicco M, ' Faldella G, Spinelli M, Corsello G, La Forgia N, Loprieno S, Boldrini A, Vuerich M, Del Vecchio A, Fabris C, Bertino E, Gaudino M, Coscia A, Fanos V, Puddu M, Gargano G, Braibanti S, Corso G, Orfeo L, De Luca MG, Paolillo P, Fabiano A, Barberi I, Barboni G, Molinari L, Bonomi A, Ladetto L, Carlucci A, Zorzi G, De Curtis M, Natale F, Di Fabio S, Faccia P, Bottau P, Macagno F, Ellero S, Magaldi R, Rinaldi M, Memo L, Nicolini G, Ngalikpima CJ, Nosari N, Sarnelli P, Parmigiani S, Agosti M, Negri C, Corona MF, Piano F, Umbaldo A, Dall’Agnola A, Girardi E, Gabriele B, Aurilia C, Romagnoli C, Lanari M, Vandini S, Adorni F, Prinelli F, Di Santo S, Silvestri M, Musicco M, ' Faldella G, Spinelli M, Corsello G, La Forgia N, Loprieno S, Boldrini A, Vuerich M, Del Vecchio A, Fabris C, Bertino E, Gaudino M, Coscia A, Fanos V, Puddu M, Gargano G, Braibanti S, Corso G, Orfeo L, De Luca MG, Paolillo P, Fabiano A, Barberi I, Barboni G, Molinari L, Bonomi A, Ladetto L, Carlucci A, Zorzi G, De Curtis M, Natale F, Di Fabio S, Faccia P, Bottau P, Macagno F, Ellero S, Magaldi R, Rinaldi M, Memo L, Nicolini G, Ngalikpima CJ, Nosari N, Sarnelli P, Parmigiani S, Agosti M, Negri C, Corona MF, Piano F, Umbaldo A, Dall’Agnola A, Girardi E, Gabriele B, Aurilia C, Romagnoli C, Lanari, Marcello, Vandini, Silvia, Adorni, Fulvio, Prinelli, Federica, Di Santo, Simona, Silvestri, Michela, and Musicco, Massimo
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Pulmonary and Respiratory Medicine ,Adult ,medicine.medical_specialty ,Pediatrics ,Time Factors ,Time Factor ,Offspring ,Longitudinal Studie ,Risk Assessment ,Tobacco smoke exposure, Pregnancy, Infant, Bronchiolitis, Hospitalization, Risk factor ,Bronchiolitis ,Hospitalization ,Infant ,Pregnancy ,Risk factor ,Tobacco smoke exposure ,Age Factors ,Female ,Humans ,Infant, Newborn ,Inhalation Exposure ,Italy ,Longitudinal Studies ,Maternal Exposure ,Risk Factors ,Smoking ,Tobacco Smoke Pollution ,Prenatal Exposure Delayed Effects ,medicine ,Age Factor ,Bronchioliti ,Intensive care medicine ,Inhalation exposure ,business.industry ,Research ,Gestational age ,Newborn ,medicine.disease ,Risk assessment ,business ,Human ,Cohort study - Abstract
Background Tobacco smoke exposure (TSE) is a worldwide health problem and it is considered a risk factor for pregnant women’s and children’s health, particularly for respiratory morbidity during the first year of life. Few significant birth cohort studies on the effect of prenatal TSE via passive and active maternal smoking on the development of severe bronchiolitis in early childhood have been carried out worldwide. Methods From November 2009 to December 2012, newborns born at ≥33 weeks of gestational age (wGA) were recruited in a longitudinal multi-center cohort study in Italy to investigate the effects of prenatal and postnatal TSE, among other risk factors, on bronchiolitis hospitalization and/or death during the first year of life. Results Two thousand two hundred ten newborns enrolled at birth were followed-up during their first year of life. Of these, 120 (5.4 %) were hospitalized for bronchiolitis. No enrolled infants died during the study period. Prenatal passive TSE and maternal active smoking of more than 15 cigarettes/daily are associated to a significant increase of the risk of offspring children hospitalization for bronchiolitis, with an adjHR of 3.5 (CI 1.5–8.1) and of 1.7 (CI 1.1–2.6) respectively. Conclusions These results confirm the detrimental effects of passive TSE and active heavy smoke during pregnancy for infants’ respiratory health, since the exposure significantly increases the risk of hospitalization for bronchiolitis in the first year of life. Electronic supplementary material The online version of this article (doi:10.1186/s12931-015-0312-5) contains supplementary material, which is available to authorized users.
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- 2015
39. Phenotypic characterization of the goat population of Santa Elena province (Ecuador).
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Solís-Lucas, L. A., Lanari, M. R., and Oyarzabal, M. I.
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ANIMAL coloration , *GOATS , *HUMAN skin color , *MUCOUS membranes , *BEARDS , *PROVINCES , *HOOFS - Abstract
It was proposed to typify phenotypically the goats of the Santa Elena province, Ecuador, and to test if there were different phenotypes. 344 animals were sampled in different types of production systems. The following variables were observed: a) morphological: coat color pattern and coat color (CCP, CC); fur and fur characteristics (FUR, CHF); pigmentation of skin, mucous membranes and hooves (SP, PMM, HP); size and arrangement of ears (ES, EO); facial profile (FP); mamellas (M); beard (B); type and orientation of horns (HT, HO); shape of rump (SR); b) morpho-structural: length and width head (HL, HW); face length (FL); ear length (EL); shoulder width (SW); depth and girth chest (CHD, CHG); cannon perimeter (CP); body length (BL); height at withers (HAW); length and width of rump (RL, RW). The multivariate analyzes performed showed 3 groups: 1) small animals; CC: red (35%), pied (33%); PMM: pigmented (43%); B: presence (44%); FP: straight (83%); ES: small (89%); EO: horizontal (47%), erect (42%); HT: arched (68%); SR: slight slope (89%). 2) wider and longer animals; medium height; CC: black (38%), red (35%); FP: straight (55%), slight convex (34%); ES: small (37%), medium (38%); EO: horizontal, erect and pendolous (84%); HT: arched (58%), curved (38%); SR: slight slope (71%). 3) taller animals; greater RL and BW; PMM: pigmented (24%); B: presence (19%); CC: red (41%), black (36%); FP: slight convex (58%), straight (39%); ES: long (51%), pendolous (64%); HT: arched (45%), straight (43%); SR: slight slope (75%). Group 1 corresponded to the oldest biotype of Santa Elena that would represent the Creole phenotype, the other two would be the result of crossings due to introductions of other races coming mainly from Loja (southern Ecuador) and Peru. [ABSTRACT FROM AUTHOR]
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- 2020
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40. Combined antiretroviral therapy reduces hyperimmunoglobulinemia in HIV-1 infected children
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Chiappini, E, Galli, L, Tovo, PA, Gabiano, C, de Martino, M, Osimani, P, Cordiali, R, De Mattia, D, Manzioma, M, DI BARI, DANIELA COLOMBA, Ruggeri, M, Masi, M, Miniaci, A, Specchia, F, Ciccia, M, Lanari, M, Baldi, F, Battisti, L, Schumacher, R, Duse, M, Fiorino, C, Dessi, C, Pintor, C, Dedoni, M, Fenu, ML, CAVALLINI, RAFFAELLA, D'ANASTASIO, ELISABETTA, Merolla, F, Sticca, M, Pomero, G, Bezzi, T, Fiumana, E, Paganelli, S, Vierucci, A, Vitucci, P, CECCHI, MARIA TERESA, Cosso, D, Timitilli, A, Stronati, M, Plebani, A, PINZANI, ROBERTO, VIGANO', ALDO, Giacomet, V, Bianchi, R, SALVINI, FRANCESCO, Zuccotti, GV, Giovannini, M, Ferraris, G, Lipreri, R, Moretti, C, Cellini, M, Cano, MC, Palazzi, G, Guarino, A, Bruzzese, E, DE MARCO, GIUSEPPINA, Tarallo, L, TANCREDI, FERNANDO ANTONIO, Giaquinto, C, D'Elia, R, Rampon, O, Nogare, EDR, SANFILIPPO, ALESSIA, Romano, A, Saitta, M, Dodi, I, Barone, A, Maccabruni, A, Consolini, R, Legitimo, A, Magnani, C, Falconieri, P, Fundaro, C, Genovese, O, Salvucci, S, Casadei, AM, Gattinara, GC, Bernardi, S, PALMA, PASQUALE, Anzidei, G, Anzidei, M, Cerilli, S, Catania, S, Ajassa, C, Ganau, A, Cristiano, L, Mazza, A, Di Palma, A, Garetto, S, Riva, C, Scolfaro, C, Portelli, V, Rabusin, M, Pellegatta, A, Molesini, M, Chiappini, E, Galli, L, Tovo, PA, Gabiano, C, de Martino, M, Osimani, P, Cordiali, R, De Mattia, D, Manzioma, M, Di Bari, C, Ruggeri, M, Masi, M, Miniaci, A, Specchia, F, Ciccia, M, Lanari, M, Baldi, F, Battisti, L, Schumacher, R, Duse, M, Fiorino, C, Dessi, C, Pintor, C, Dedoni, M, Fenu, ML, Cavallini, R, Anastasio, E, Merolla, F, Sticca, M, Pomero, G, Bezzi, T, Fiumana, E, Paganelli, S, Vierucci, A, Vitucci, P, Cecchi, MT, Cosso, D, Timitilli, A, Stronati, M, Plebani, A, Pinzani, R, Vigano, A, Giacomet, V, Bianchi, R, Salvini, F, Zuccotti, GV, Giovannini, M, Ferraris, G, Lipreri, R, Moretti, C, Cellini, M, Cano, MC, Palazzi, G, Guarino, A, Bruzzese, E, De Marco, G, Tarallo, L, Tancredi, F, Giaquinto, C, D'Elia, R, Rampon, O, Nogare, EDR, Sanfilippo, A, Romano, A, Saitta, M, Dodi, I, Barone, A, Maccabruni, A, Consolini, R, Legitimo, A, Magnani, C, Falconieri, P, Fundaro, C, Genovese, O, Salvucci, S, Casadei, AM, Gattinara, GC, Bernardi, S, Palma, P, Anzidei, G, Anzidei, M, Cerilli, S, Catania, S, Ajassa, C, Ganau, A, Cristiano, L, Mazza, A, Di Palma, A, Garetto, S, Riva, C, Scolfaro, C, Portelli, V, Rabusin, M, Pellegatta, A, and Molesini, M
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Adult ,medicine.medical_specialty ,Adolescent ,immunogiobulins ,Immunology ,immunoglobulins ,combined antiretroviral therapy ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,Gastroenterology ,children ,Hypergammaglobulinemia ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Child ,Therapeutic regimen ,biology ,business.industry ,Immunoglobulins, Intravenous ,Infant ,Normal population ,hiv-1 infection ,Settore MED/38 ,Antiretroviral therapy ,HIV Reverse Transcriptase ,Infectious Diseases ,Child, Preschool ,Intravenous IG ,HIV-1 ,biology.protein ,HIV-1 infection ,Drug Evaluation ,Reverse Transcriptase Inhibitors ,Drug Therapy, Combination ,Antibody ,business ,Viral load - Abstract
Objective: To evaluate the effect of combined antiretroviral therapy on serum immunoglobulin (Ig) levels in HIV-1 perinatally infected children.Methods: Data from 1250 children recorded by the Italian Register for HIV Infection in Children from 1985 to 2002 were analysed. Since Ig levels physiologically vary with age, differences at different age periods were evaluated as differences in z-scores calculated using means and standard deviations of normal population for each age period. Combined antiretroviral therapy has become widespread in Italy since 1996, thus differences in Ig z-scores between the periods 1985-1995 and 1996-2002 were analysed. Data according to type of therapeutic regimen were also analysed.Results: Between the two periods 1985-1995 and 1996-2002, significant (P < 0.0001) decreases in IgG (6.29 +/- 4.72 versus 4.44 +/- 4.33), IgM (9.25 +/- 13.32 versus 5.61 +/- 7.93), and IgA (10.25 +/- 15.68 versus 6.48 +/- 11.56) z-scores, together with a parallel significant (P < 0.0001) increase in CD4 T-lymphocyte percentages, were found. These decreases were confirmed regardless of whether the children were receiving intravenous Ig or not. Ig z-scores were significantly higher in children receiving mono-therapy than in those receiving double-combined therapy (IgG, P < 0.0001; IgM, P = 0.003; IgA, P = 0.031) and in the latter children than in those receiving three or more drugs (P < 0.0001 for all z-scores). Ig z-scores correlated inversely with CD4 T lymphocyte percentages and, directly, with viral loads.Conclusions: Our data show that in HIV-1 infected children combined antiretroviral therapy leads to reduction of hyperimmunoglobulinemia which parallels restoration of CD4 T-lymphocyte percentage and viral load decrease, which it turn probably reflects improved B-lymphocyte functions.(C) 2004 Lippincott Williams Wilkins.
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- 2004
41. Atherosclerosis precursors in children. The Bologna study. Preliminary data
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Salvioli, G. P., Faldella, G., Alessandroni, R., Rossini, R., Lanari, M., Alati, S., De Marchis, C., Lenzi, S., editor, and Descovich, G. C., editor
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- 1987
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42. EL TRASPATIO FOMENTADO COMO UNA OPCIÓN DE PRODUCCIÓN SUSTENTABLE POR UN COLECTIVO DE CONBIAND
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Rodríguez G., Aznar J., Camacho M.E., Carolino N., Hernández J.S., Lanari M., Perezgrovas R., Reising C.A., Stemmer A., Zaragoza M.L.
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lcsh:Genetics ,lcsh:QH426-470 ,lcsh:Animal culture ,lcsh:SF1-1100 - Published
- 2012
43. Duration of ruptured membranes and vertical transmission of HIV-1: a meta-analysis from 15 prospective cohort studies
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Bulterys, M. B., Fowler, M. G., Hanson, I. C., Lemay, M., Mayaux, M. J., Mofenson, L., Newell, M. -L., Peavy, H., Peckham, C., Read, J. S., Rother, C., Simpson, B. J., Van Dyke, R. B., Harris, D. R., Peavy, H. H., Easley, K., Khammy, A., Nugent, R. P., Mitchell, R., Owen, W., Van Dyke, R., Widmayer, S., Bardeguez, A., Hanson, C., Wiznia, A., Luzuriaga, K., Viscarello, R., Ho, D., Koup, R., Chen, I., Krogstad, P., Mullins, J., Wolinsky, S., Korber, B., Walker, B., Ammann, A., Clapp, S., Mcdonald, D., Lapointe, N., Boucher, M., Fauvel, M., Hankins, C., Samson, J., Newell, M. L., Peckham, C. S., Thorne, C. N., Giaquinto, C., Ruga, E., De Rossi, A., Truscia, D., Grosch-Worner, I., Schafer, A., Mok, J., Johnstone, F., Jiminez, J., de Alba, C., Garcia Rodriguez, M. C., Bates, I., de Josee, I., Hawkins, F., Martinez Zapico, R., Pena, J. M., Gonzalez Garcia, J., Arribas Lopez, J. R., Asensi-Botet, F., Otero, M. C., Peerez-Tamarit, D., Moya, A., Galbis, M. J., Scherpbier, H., Boer, K., Bohlin, A. B., Lindgren, S., Anzen, B., Belfrage, E., Lidin-Jansson, G., Levy, J., Barlow, P., Hainaut, M., Peltier, A., Ferrazin, A., De Maria, A., Gotta, C., Mur, A., Vinolas, M., Paya, A., Loepez-Vilchez, M. A., Coll, O., Fortuny, C., Boguna, J., Casellas Caro, M., Canet, Y., Pardi, G., Ravizza, M., Semprini, E., Castagna, C., Fiore, S., Guerra, B., Lanari, M., Bianchi, S., Bovicelli, L., Prati, E., Zanelli, S., Duse, M., Soresina, A., Scaravelli, G., Stegagno, M., De Santis, M., Muggiasca, M. L., Vigano, A., Spinillo, A., Ravagni Probizer, F., Bucceri, A., Rancilio, L., Taylor, G. P., Lyall, H., Penn, Z., Blott, M., Valerius, N. H., Martinelli, P., Buffolano, W., Tibaldi, C., Ziarati, N., Semprini, A., Della Torre, M., Parazzini, F., Dallacasa, P., Bianchi, U., Pachi, A., Mancuso, S., Villa, P., Conti, M., Principi, N., Muggiasca, M., Marchisio, P., Zara, C., Ravagni, F., Vignali, M., Rossi, G., Selvaggi, L., Greco, P., Vimercati, A., Massi, G., Innocenti, T., Fiscella, A., Sansone, M., Benedetto, C., Tadrist, B., Thevenieau, D., Gondry, J., Paulard, B., Alisy, C., Brault, D., Tordjeman, N., Mamou, J., Rozan, M., Colombani, D., Pincemaille, O., Salvetti, A., Chabanier, C., Hernandorena, X., Leroy, J., Schaal, J., Balde, P., Faucher, P., Lachassinne, E., Benoit, S., Douard, D., Hocke, C., Barjot, P., Brouard, J., Delattre, P., Stien, L., Audibert, F., Labrune, P., Vial, M., Mazy, F., Sitbon, D., Crenn-Hebert, C., Floch-Tudal, C., Akakpo, R., Daveau, C., Leblanc, A., Cesbron, P., Duval-Arnould, M., Huraux-Rendu, C., Lemerle, S., Touboul, C., Guerin, M., Maingueneau, C., Reynaud, I., Rousseau, T., Ercoil, V., Lanza, M., Denavit, M., Garnier, J., Lahsinat, K., Pia, P., Allouche, C., Nardou, M., Grall, F., May, A., Dallot, M., Lhuillier, P., Cecile, W., Mezin, R., Bech, A., Lobut, J., Algava, G., Chalvon Dermesay, A., Busuttil, R., Jacquemot, M., Bader-Meunier, B., Fridman, S., Codaccioni, X., Maxingue, F., Thomas, D., Alain, J., De Lumley, L., Tabaste, J., Bailly Salin, P., Seaume, H., Guichard, A., Kebaill, K., Roussouly, C., Botto, C., De Lanete, A., Wipff, P., Cravello, L., De Boisse, P., Leclaire, M., Michel, G., Crumiere, C., Lefevre, V., Le Lorier, B., Pauly, I., Robichez, B., Seguy, D., Delhinger, M., Rideau, F., Talon, P., Benos, P., Huret, C., Nicolas, J., Heller-Roussin, B., Saint-Leger, S., Delaporte, M., Hubert, C., De Sarcus, B., Karoubi, P., Mechinaud, F., Bertcrottiere, D., Bongain, A., Monpoux, F., De Gennes, C., Devianne, F., Nisand, I., Rousset, M., Mouchnino, G., Muray, J., Munzer, M., Quereux, C., Brossard, V., Clavier, B., Allemon, M., Rotten, D., Stephan, J., Varlet, M., Guyot, B., Narcy, P., Bardinet, F., De Caunes, F., Jeny, R., Robin, M., Raison Boulley, A., Savey, L., Berrebi, A., Tricoire, J., Borderon, J., Fignon, A., Guillot, F., Maria, B., Broyard, A., Chitrit, Y., Firtion, G., Mandelbrot, L., Lafay Pillet, M., Parat, S., Boissinot, C., Garec, N., Levine, M., Ottenwalter, A., Schaller, F., Vilmer, E., Courpotin, C., Brunner, C., Ciraru-Vigneron, N., Hatem-Gantzer, G., Fritel, X., Wallet, A., Bouille, J., Milliez, J., Bensaid Mrejen, D., Dermer, E., Noseda, G., Bardou, D., Cressaty, J., Francoual, C., Carlus Moncomble, C., Cohen, H., Blanche, S., Bastion, H., Benifla, J., Benkhatar, F., Berkane, N., Hervee, F., Ronzier, M., Mayaux, Mj., de Martino, M., Tovo, P. -A., Galli, L., Gabiano, C., Ferraris, G., Garetto, S., Palomba, E., Riva, C., Vierucci, A., de Luca, M., Farina, S., Fundaro, C., Genovese, O., Mereu, G., Forni, G. L., Casadei, A., Zuccotti, G. V., Riva, E., Cellini, M., Baraldi, C., Consolini, R., Palla, G., Ruggeri, M., Ciccimarra, F., Guarino, A., Osimani, P., Benaglia, G., Romano, A., De Mattia, D., Caselli, D., Boni, S., Dell'Erba, G., Bassanetti, F., Sticca, M., Timpano, C., Magnani, C., Salvatore, C., Lipreri, R., Tornaghi, R., Pinzani, R., Cecchi, M. T., Bezzi, T., Battisti, L., Bresciani, E., Castelli Gattinara, G., Nasi, C., Pellegatta, A., Mazza, A., Baldi, F., Altobelli, R., Deiana, M., Colnaghi, C., Tarallo, L., Tondo, U., Anastasio, E., Chiriaco, P. G., Ruggeri, C., Scott, G., Hutto, C., O'Sullivan, M., Malmsberry, A., Willoughby, A., Burns, D., Goedert, J., Landesman, S., Minkoff, H., Mendez, H., Holman, S., Rubinstein, A., Durako, S., Muenz, L., Goodwin, S., Bryson, Y., Dillon, M., Nielsen, K., Boyer, P., Liao, D., Keller, M., Deveikis, A., Nesheim, S., Lindsay, M., Lee, F., Nahmias, A., Sawyer, M., Vink, P., Farley, J., Alger, L., Abrams, E., Bamji, M., Lambert, G., Schoenbaum, E., Thomas, P., Weedon, J., Palumbo, P., Denny, T., Oleske, J., Bulterys, M., Simonds, R., Ethier-Ives, J., Rogers, M., Schluchter, M., Kutner, M., Kaplan, S., Kattan, M., Lipshultz, S., Mellins, R., Shearer, W., Sopko, G., Sloand, E., Wu, M., Kind, C., Nadal, D., Rudin, C., Siegrist, C. -A., Wyler, C. -A., Cheseaux, J. -J., Aebi, C., Gnehm, H., Schubiger, G., Klingler, J., Hunziker, U., Kuchler, H., Gianinazzi, M., Buhlmann, U., Biedermann, K., Lauper, U., Irion, O., Brunelli, A., Spoletini, G., Schreyer, A., Hosli, I., Saurenmann, E., Drack, G., Isenschmid, M., Poorbeik, M., Schupbach, J., Perrin, L., Erb, P., Joller, H., Kovacs, A., Stek, A., Chan, L., Khoury, M., Diaz, C., Pacheco-Acosta, E., Tuomala, R., Cooper, E., Mesthene, D., Pitt, J., Higgins, A., Moroso, G., Rich, K., Turpin, D., Cooper, N., Davenny, K., Thompson, B., Andiman, W., Simpson, J., THE INTERNATIONAL PERINATAL HIV, Group, Martinelli, Pasquale, Bulterys M.B., Fowler M.G., Hanson I.C., Lemay M., Mayaux M.J., Mofenson L., Newell M.-L., Peavy H., Peckham C., Read J.S., Rother C., Simpson B.J., Van Dyke R.B., Harris D.R., Peavy H.H., Easley K., Khammy A., Nugent R.P., Mitchell R., Owen W., Van Dyke R., Widmayer S., Bardeguez A., Hanson C., Wiznia A., Luzuriaga K., Viscarello R., Ho D., Koup R., Chen I., Krogstad P., Mullins J., Wolinsky S., Korber B., Walker B., Ammann A., Clapp S., McDonald D., Lapointe N., Boucher M., Fauvel M., Hankins C., Samson J., Newell M.L., Peckham C.S., Thorne C.N., Giaquinto C., Ruga E., De Rossi A., Truscia D., Grosch-Worner I., Schafer A., Mok J., Johnstone F., Jiminez J., de Alba C., Garcia Rodriguez M.C., Bates I., de Josee I., Hawkins F., Martinez Zapico R., Pena J.M., Gonzalez Garcia J., Arribas Lopez J.R., Asensi-Botet F., Otero M.C., Peerez-Tamarit D., Moya A., Galbis M.J., Scherpbier H., Boer K., Bohlin A.B., Lindgren S., Anzen B., Belfrage E., Lidin-Jansson G., Levy J., Barlow P., Hainaut M., Peltier A., Ferrazin A., De Maria A., Gotta C., Mur A., Vinolas M., Paya A., Loepez-Vilchez M.A., Coll O., Fortuny C., Boguna J., Casellas Caro M., Canet Y., Pardi G., Ravizza M., Semprini E., Castagna C., Fiore S., Guerra B., Lanari M., Bianchi S., Bovicelli L., Prati E., Zanelli S., Duse M., Soresina A., Scaravelli G., Stegagno M., De Santis M., Muggiasca M.L., Vigano A., Spinillo A., Ravagni Probizer F., Bucceri A., Rancilio L., Taylor G.P., Lyall H., Penn Z., Blott M., Valerius N.H., Martinelli P., Buffolano W., Tibaldi C., Ziarati N., Semprini A., Della Torre M., Parazzini F., Dallacasa P., Bianchi U., Pachi A., Mancuso S., Villa P., Conti M., Principi N., Muggiasca M., Marchisio P., Zara C., Ravagni F., Vignali M., Rossi G., Selvaggi L., Greco P., Vimercati A., Massi G., Innocenti T., Fiscella A., Sansone M., Benedetto C., Tadrist B., Thevenieau D., Gondry J., Paulard B., Alisy C., Brault D., Tordjeman N., Mamou J., Rozan M., Colombani D., Pincemaille O., Salvetti A., Chabanier C., Hernandorena X., Leroy J., Schaal J., Balde P., Faucher P., Lachassinne E., Benoit S., Douard D., Hocke C., Barjot P., Brouard J., Delattre P., Stien L., Audibert F., Labrune P., Vial M., Mazy F., Sitbon D., Crenn-Hebert C., Floch-Tudal C., Akakpo R., Daveau C., Leblanc A., Cesbron P., Duval-Arnould M., Huraux-Rendu C., Lemerle S., Touboul C., Guerin M., Maingueneau C., Reynaud I., Rousseau T., Ercoil V., Lanza M., Denavit M., Garnier J., Lahsinat K., Pia P., Allouche C., Nardou M., Grall F., May A., Dallot M., Lhuillier P., Cecile W., Mezin R., Bech A., Lobut J., Algava G., Chalvon Dermesay A., Busuttil R., Jacquemot M., Bader-Meunier B., Fridman S., Codaccioni X., Maxingue F., Thomas D., Alain J., De Lumley L., Tabaste J., Bailly Salin P., Seaume H., Guichard A., Kebaill K., Roussouly C., Botto C., De Lanete A., Wipff P., Cravello L., De Boisse P., Leclaire M., Michel G., Crumiere C., Lefevre V., Le Lorier B., Pauly I., Robichez B., Seguy D., Delhinger M., Rideau F., Talon P., Benos P., Huret C., Nicolas J., Heller-Roussin B., Saint-Leger S., Delaporte M., Hubert C., De Sarcus B., Karoubi P., Mechinaud F., Bertcrottiere D., Bongain A., Monpoux F., De Gennes C., Devianne F., Nisand I., Rousset M., Mouchnino G., Muray J., Munzer M., Quereux C., Brossard V., Clavier B., Allemon M., Rotten D., Stephan J., Varlet M., Guyot B., Narcy P., Bardinet F., De Caunes F., Jeny R., Robin M., Raison Boulley A., Savey L., Berrebi A., Tricoire J., Borderon J., Fignon A., Guillot F., Maria B., Broyard A., Chitrit Y., Firtion G., Mandelbrot L., Lafay Pillet M., Parat S., Boissinot C., Garec N., Levine M., Ottenwalter A., Schaller F., Vilmer E., Courpotin C., Brunner C., Ciraru-Vigneron N., Hatem-Gantzer G., Fritel X., Wallet A., Bouille J., Milliez J., Bensaid Mrejen D., Dermer E., Noseda G., Bardou D., Cressaty J., Francoual C., Carlus Moncomble C., Cohen H., Blanche S., Bastion H., Benifla J., Benkhatar F., Berkane N., Hervee F., Ronzier M., Mayaux MJ., de Martino M., Tovo P.-A., Galli L., Gabiano C., Ferraris G., Garetto S., Palomba E., Riva C., Vierucci A., de Luca M., Farina S., Fundaro C., Genovese O., Mereu G., Forni G.L., Casadei A., Zuccotti G.V., Riva E., Cellini M., Baraldi C., Consolini R., Palla G., Ruggeri M., Ciccimarra F., Guarino A., Osimani P., Benaglia G., Romano A., De Mattia D., Caselli D., Boni S., Dell'Erba G., Bassanetti F., Sticca M., Timpano C., Magnani C., Salvatore C., Lipreri R., Tornaghi R., Pinzani R., Cecchi M.T., Bezzi T., Battisti L., Bresciani E., Castelli Gattinara G., Nasi C., Pellegatta A., Mazza A., Baldi F., Altobelli R., Deiana M., Colnaghi C., Tarallo L., Tondo U., Anastasio E., Chiriaco P.G., Ruggeri C., Scott G., Hutto C., O'Sullivan M., Malmsberry A., Willoughby A., Burns D., Goedert J., Landesman S., Minkoff H., Mendez H., Holman S., Rubinstein A., Durako S., Muenz L., Goodwin S., Bryson Y., Dillon M., Nielsen K., Boyer P., Liao D., Keller M., Deveikis A., Nesheim S., Lindsay M., Lee F., Nahmias A., Sawyer M., Vink P., Farley J., Alger L., Abrams E., Bamji M., Lambert G., Schoenbaum E., Thomas P., Weedon J., Palumbo P., Denny T., Oleske J., Bulterys M., Simonds R., Ethier-Ives J., Rogers M., Schluchter M., Kutner M., Kaplan S., Kattan M., Lipshultz S., Mellins R., Shearer W., Sopko G., Sloand E., Wu M., Kind C., Nadal D., Rudin C., Siegrist C.-A., Wyler C.-A., Cheseaux J.-J., Aebi C., Gnehm H., Schubiger G., Klingler J., Hunziker U., Kuchler H., Gianinazzi M., Buhlmann U., Biedermann K., Lauper U., Irion O., Brunelli A., Spoletini G., Schreyer A., Hosli I., Saurenmann E., Drack G., Isenschmid M., Poorbeik M., Schupbach J., Perrin L., Erb P., Joller H., Kovacs A., Stek A., Chan L., Khoury M., Diaz C., Pacheco-Acosta E., Tuomala R., Cooper E., Mesthene D., Pitt J., Higgins A., Moroso G., Rich K., Turpin D., Cooper N., Davenny K., Thompson B., Andiman W., and Simpson J.
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Time Factors ,Epidemiology ,Infectious Disease Transmission ,Prevention of perinatal transmission ,Extraembryonic Membranes ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,Cohort Studies ,Pregnancy ,Risk Factors ,INFECTION ,Vertical ,Immunology and Allergy ,HIV Infection ,MOTHER-TO-CHILD ,Pregnancy Complications, Infectious ,Prospective cohort study ,prevention of perinatal transmission ,vertical transmission ,obstetrics/gynaecology ,epidemiology ,Obstetrics ,Transmission (medicine) ,Infectious ,HUMAN-IMMUNODEFICIENCY-VIRUS, MOTHER-TO-CHILD, ZIDOVUDINE PROPHYLAXIS, RISK-FACTORS, TYPE-1, PREGNANCY, INFECTION, TRIAL, PREVENTION ,Breast Feeding ,Infectious Diseases ,Meta-analysis ,HUMAN-IMMUNODEFICIENCY-VIRUS ,Vertical transmission ,Regression Analysis ,TRIAL ,Female ,Delivery ,Obstetrics gynaecology ,Human ,medicine.medical_specialty ,Time Factor ,Ruptured membranes ,Immunology ,Regression Analysi ,NO ,ZIDOVUDINE PROPHYLAXIS ,Extraembryonic Membrane ,medicine ,Humans ,TYPE-1 ,business.industry ,Risk Factor ,Infant, Newborn ,Infant ,Obstetric ,Delivery, Obstetric ,Newborn ,PREVENTION ,Infectious Disease Transmission, Vertical ,Pregnancy Complications ,Obstetrics/gynaecology ,RISK-FACTORS ,Cohort Studie ,business - Abstract
Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospective cohort studies including at least 100 mother-child pairs, from regions where HIV-infected women are counselled not to breastfeed. Analyses were restricted to vaginal deliveries and non-elective Cesarean sections; elective Cesarean section deliveries (those performed before onset of labour and before rupture of membranes) were excluded. Results: The primary analysis included 4721 deliveries with duration of ruptured membranes ≤ 24 h. After adjusting for other factors known to be associated with vertical transmission using logistic regression analysis to assess the strength of the relationship, the risk of vertical HIV transmission increased approximately 2% with an increase of 1 h in the duration of ruptured membranes [adjusted odds ratio, 1.02; 95% confidence interval, 1.01-1.04; for each 1 h increment]. There were no significant interactions of duration of ruptured membranes with study cohort or with any of the covariates, except maternal AIDS. Among women diagnosed with AIDS, the estimated probability of transmission increased from 8% to 31% with duration of ruptured membranes of 2 h and 24 h respectively (P < 0.01). Conclusions: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes. © 2001 Lippincott Williams & Wilkins.
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- 2001
44. Potential serotype coverage of three pneumococcal conjugate vaccines against invasive pneumococcal infection in Italian children
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Azzari, Chiara, Moriondo, Maria, Cortimiglia, Martina, Valleriani, C, Canessa, C, Indolfi, G, Ricci, S, De Martino, Maurizio, Resti, M, Collaborators: Agostiniani R, Italian group for the study of Invasive Pneumococcal D. i. s. e. a. s. e., Allievi, P, Allù, G, Amigoni, A, Bernardi, P, Bernardini, R, Biban, P, Bigi, M, Boldrini, A, Bossi, G, Bottone, U, Cardinale, A, Cardona, A, Castronari, R, Celandroni, A, Chiossi, M, Colleselli, P, Correra, A, D'Ascola, G, D'Aquino, A, De Benedictis FM, Dini, E, Dollfus, L, Domenici, R, Flacco, V, Furbetta, M, Gaetti, Mt, Gagliardi, L, Giani, I, Giglio, P, Guala, A, Lanari, M, Lippi, F, Lizzoli, C, Lombardi, E, Macchia, Pa, Magnini, M, Memmini, G, Mesirca, P, Micheletti, E, Migliozzi, L, Nunziata, F, Pecile, P, Pepe, G, Perferi, G, Peris, A, Perri, Pf, Pescollderungg, L, Pezzati, M, Poggi, Giovanni Maria, Prato, R, Principi, N, Rapisardi, G, Regoli, M, Riva, A, Rizzo, L, Roman, B, Toffolo, A, Strano, M, Trapani, Sandra, Vasarri, P, Vascotto, M, Vecchi, V, Ventura, A, Verini, M, Zorzi, C., Azzari, Chiara, Moriondo, Maria, Cortimiglia, Martina, Valleriani, Claudia, Canessa, Clementina, Indolfi, Giuseppe, Ricci, Silvia, Nieddu, Francesco, de Martino, Maurizio, Resti, Massimo, Italian group for the study of Invasive Pneumococcal Disease [, Lanari, Marcello, and ]
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Pneumococcal Vaccine ,Male ,Serotype ,medicine.medical_specialty ,Adolescent ,Sepsi ,Vaccination schedule ,Longitudinal Studie ,Bacteremia ,Real-Time Polymerase Chain Reaction ,medicine.disease_cause ,Pneumococcal Vaccines ,Sepsis ,Internal medicine ,Streptococcus pneumoniae ,medicine ,Humans ,Longitudinal Studies ,Serotyping ,Child ,Vaccines, Conjugate ,Bacterial disease ,General Veterinary ,General Immunology and Microbiology ,Meningitis, Pneumococcal ,business.industry ,Public Health, Environmental and Occupational Health ,Infant ,medicine.disease ,Pneumonia ,Infectious Diseases ,Italy ,Child, Preschool ,Pneumococcal pneumonia ,Immunology ,Molecular Medicine ,Female ,business ,Meningitis ,Human - Abstract
Background and aim of the work Since the introduction of the 7-valent vaccine, invasive pneumococcal disease have greatly decreased; however, changes in the distribution of pneumococcal serotypes have recently highlighted the need for vaccines with wider coverage. The aim of the work was to assess the potential serotype coverage of three pneumococcal conjugate vaccines (7-, 10- and 13-valent) against bacteremic pneumococcal pneumonia and meningitis/sepsis in Italian children. Patients and methods We determined pneumococcal serotypes in immunocompetent patients who had been admitted to hospital with suspicion of invasive bacterial disease and had confirmed bacteremic pneumococcal pneumonia or meningitis/sepsis determined by molecular detection of Streptococcus pneumoniae in a normally sterile site. Positive samples were serotyped using Realtime-PCR. Results Between April 2008 and March 2011, a total of 144 patients (age median 4.1 years; Interquartile range 1.8–5.6) with pneumococcal meningitis/sepsis (n = 43) or pneumonia (n = 101) from 83 participating centers located in 19 of 20 Italian regions were serotyped. The 10 most prevalent serotypes were 1 (29.9%), 3 (16.0%), 19A (13.2%), 7F (8.3%), 5 (4.2%), 14 (4.2%), 6A (3.5%), 6B (3.5%), 18C (3.5%), 19F (3.5%). Overall, serotype coverage for PCV-7, -10 and -13 were respectively 19.4%, 61.8% and 94.4% with no statistical difference between pneumonia and meningitis/sepsis. Potential coverage was similar for children 0–2 or 2–5 years of age. Cultures resulted positive in 35/99 (35.4%) samples simultaneously obtained for both culture and RT-PCR. Conclusion These findings indicate that increasing the potential serotype coverage by introducing PCV13 in the vaccination schedule for infancy could provide substantial added benefit for protection from pneumococcal pneumonia or meningitis/sepsis in Italy in children below 2 years as well in older children. The importance of molecular methods for diagnosis and serotyping of invasive pneumococcal disease was confirmed.
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- 2012
45. The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population-based study
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Berardi, Alberto, Baroni, Lorenza, Bacchi Reggiani, Maria Letizia, Ambretti, Simone, Biasucci, Giacomo, Bolognesi, Serenella, Capretti, Maria Grazia, Carretto, Edoardo, Ciccia, Matilde, Fiorini, Valentina, Fortini, Cinzia, Gargano, Giancarlo, Pedna, Maria Federica, Rizzo, Vittoria, Creti, Roberta, Ferrari, Fabrizio, Memo, L., Nicolini, G., Campanile, A., Tridapalli, E., Ciccia, M., Bastelli, A., Sandri, F., Ambretti, S., Capretti, M. G., Gentili, A., Ragni, L., Albarelli, A., Piscina, A., Borghi, A., Simoni, A., Fiorini, V., Grande, E. D., Polese, A., Biasini, A., China, M. C., Rizzo, V., Zucchini, A., Malaguti, L., Contiero, R., Fortini, C., Garani, G., Rossi, M. R., Nasi, S., Bacchini, P., Baldassarri, P., Pulvirenti, R. M., Vaienti, F., Venturoli, V., Bidetti, M. L., Colla, R., Toniato, M., Carlo, C. D., Lanari, M., Serra, L., Silvestrini, D., Facchinetti, F., Ferrari, F., Lugli, L., Venturelli, C., Sarti, M., Volta, A., Dodi, I., Gambini, L., Guidi, B., Bertelli, M., Biasucci, G., Chiarabini, R., Padrini, D., Piepoli, M., Riboni, S., Rubbi, P., Pedna, M. F., Sambri, V., Perrone, A., Preti, P., Marchetti, F., Piccinini, G. C., Amarri, S., Carretto, E., Gargano, G., Pedori, S., Riva, M., Rossi, C., Zuelli, C., Bolognesi, S., Papa, I., Vergine, G., Viola, L., Chiossi, C., Pagano, R., Zanacca, C., Palmieri, R., Berardi, Alberto, Baroni, Lorenza, Bacchi Reggiani, Maria Letizia, Ambretti, Simone, Biasucci, Giacomo, Bolognesi, Serenella, Capretti, Maria Grazia, Carretto, Edoardo, Ciccia, Matilde, Fiorini, Valentina, Fortini, Cinzia, Gargano, Giancarlo, Pedna, Maria Federica, Rizzo, Vittoria, Creti, Roberta, Ferrari, Fabrizio, and GBS Prevention Working Group Emilia-Romagna [,Lanari, Marcello,]
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Pediatrics ,Antibiotics ,group B streptococcu ,Logistic regression ,medicine.disease_cause ,Severity of Illness Index ,Group B ,0302 clinical medicine ,Risk Factors ,Medicine ,Birth Weight ,030212 general & internal medicine ,Escherichia coli Infections ,Streptococcus ,Gestational age ,meningitis ,Obstetrics and Gynecology ,Drug Resistance, Microbial ,intrapartum chemoprophylaxi ,Perinatology and Child Health ,meningiti ,Anti-Bacterial Agents ,Italy ,Regression Analysis ,Neonatal Sepsis ,Meningitis ,Early-onset sepsis ,group B streptococcus ,intrapartum chemoprophylaxis ,newborn infant ,Pediatrics, Perinatology and Child Health ,Infant, Premature ,Cohort study ,medicine.medical_specialty ,medicine.drug_class ,Statistics, Nonparametric ,Streptococcus agalactiae ,Sepsis ,03 medical and health sciences ,030225 pediatrics ,Streptococcal Infections ,Escherichia coli ,Humans ,Retrospective Studies ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Early-onset sepsi ,Ampicillin ,Gentamicins ,business - Abstract
Objective: To provide the first Italian data on pathogens causing early-onset sepsis (EOS) and their antimicrobial susceptibility, after the successfully prevention of Group B streptococcus (GBS) EOS. Methods: Retrospective area-based cohort study from Emilia-Romagna (Italy). Cases of EOS registered (from 2009 to 2012) in all gestational age neonates were reviewed. Results: Live births (LB) numbered 146 682. Ninety neonates had EOS and 12 died (incidence rates of 0.61 and 0.08/1000 LB, respectively). EOS and mortality were the highest among neonates with a birth weight n = 27, 0.18/1000 LB) and Escherichia coli (n = 19, 0.13/1000 LB). Most infants affected by E. coli EOS were born preterm (n = 13), had complications (n = 4) or died (n = 7). Among 90 isolates tested, only 3 were resistant to both first line empirical antibiotics. Multivariate logistic regression analysis showed that low gestational age, caesarean section and low platelet count at presentation were significantly associated with death or brain lesions (area under ROC curve = 0.939, H-L = 0.944, sensitivity 76.0%, specificity 90.7%). Conclusions: GBS slightly exceeds E. coli as a cause of EOS. However, E. coli is the prominent cause of death, complications and in most cases affects preterm neonates. Empirical antimicrobial therapy of EOS seems appropriate.
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- 2015
46. Combination antiretroviral therapy and duration of pregnancy
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Aebi, C, Battegay, M, Bernasconi, E, Biedermann, K, Cheseaux, JJ, Drack, G, Erb, P, Flepp, M, Francioli, P, Furrer, HJ, Gianinazzi, MP, Gyr, T, Hirschel, B, Hosli, I, Hug, I, Irion, O, Keller, K, Kind, C, Laubereau, B, Lauper, U, Lorenzi, P, Matter, L, Nadal, D, Perrin, L, Rickenbach, M, Rudin, C, Schreyer, A, Schupbach, J, Telenti, A, Vernazza, P, Wolf, K, Wunder, D, Wyler, CA, Giaquinto, C, Ruga, E, De Rossi, A, Grosch-Worner, I, Seel, K, Schafer, A, Mok, J, Johnstone, F, Jimenez, J, Garcia-Rodriguez, MC, Bates, I, de Jose, I, Hawkins, F, de Gevara, CL, Pena, JM, Garcia, JG, Lopez, JRA, Asensi-Botet, F, Otero, MC, Perez-Tamarit, D, Ridaura, S, Gregori, P, de la Torre, R, Scherpbier, H, Kreyenbroek, M, Boer, K, Bohlin, AB, Lindgren, S, Ehrnst, A, Belfrage, E, Lidman, K, Christensson, B, Levy, J, Hainaut, M, Peltier, A, Barlow, P, Wibaut, S, Lecroart, MC, Ferrazin, A, Bassetti, D, De Maria, A, Gotta, C, Mur, A, Paya, A, Vinolas, M, Lopez-Vilchez, MA, Martinez-Gomez, P, Carreras, R, Coll, O, Fortuny-Guasch C, Boguna, J, Caro, MC, Canet, Y, Pardi, G, Ravizza, M, Guerra, B, Lanari, M, Bianchi, S, Bovicelli, L, Prati, E, Duse, M, Scaravelli, G, Stegagno, M, De Santis, M, Semprini, AE, Savasi, V, Vigano, A, Probizer, FR, Maccabruni, A, Bucceri, A, Rancilio, L, Taylor, GP, Lyall, H, Penn, Z, Valerius, NH, Martinelli, P, Buffolano, W, Sansone, M, Tibaldi, C, Ziarati, N, Benedetto, C, Niemiec, T, Horban, A, Newell M.-L., Aebi C., Battegay M., Bernasconi E., Biedermann K., Cheseaux J.-J., Drack G., Erb P., Flepp M., Francioli P., Furrer H.J., Gianinazzi M.-P., Gyr T., Hirschel B., Hosli I., Hug I., Irion O., Keller K., Kind C., Laubereau B., Lauper U., Lorenzi P., Matter L., Naddal D., Perrin L., Rickenbach M., Rudin C., Schreyer A., Schupbach J., Telenti A., Vernazza P., Wolf K., Wunder D., Wyler C.-A., Giaquinto C., Ruga E., De Rossi A., Grosh-Worner I., Seel K., Schafer A., Mok J., Johnstone F., Jimenez J., Garcia-Rodriguez M.C., Bates I., De Jose I., Hawkins F., Ladron de Gevara C., Ma Pena J., Gonzalez Garcia J., Arribas Lopez J.R., Asensi-Botet F., Otero M.C., Perez-Tamarit D., Ridaura S., Gregori P., De la Torre R., Scherpbier H., Kreyenbroek M., Boer K., Bohlin A.B., Lindgren S., Ehrnst A., Belfrage E., Lidman K., Christensson B., Levy J., Hainaut M., Peltier A., Barlow P., Wibaut S., Lecroart M.C., Ferrazin A., Bassetti D., De Maria A., Gotta C., Mur A., Paya A., Vinolas M., Lopez-Vilchez M.A., Martinez-Gomez P., Carreras R., Coll O., Fortuny C., Boguna J., Casellas Caro M., Canet Y., Pardi G., Ravizza M., Guerra B., Lanari M., Bianchi S., Bovicelli L., Prati E., Duse M., Scaravelli G., Stegagno M., De Santis M., and Semprini A.E.
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Epidemiology ,HIV Infections ,Substance Abuse, Intravenou ,Cohort Studies ,Pregnancy ,Immunology and Allergy ,Medicine ,HIV Infection ,Prospective Studies ,Pregnancy Complications, Infectious ,Substance Abuse, Intravenous ,Prospective cohort study ,Obstetrics ,Infectious ,Substance Abuse ,Pregnancy Outcome ,Gestational age ,Viral Load ,Antiretroviral therapy ,Reverse Transcriptase Inhibitor ,Infectious Diseases ,Combination ,Reverse Transcriptase Inhibitors ,Drug Therapy, Combination ,Female ,Intravenous ,Prematurity ,Delivery ,Zidovudine ,Viral load ,Infant, Premature ,Human ,Cohort study ,medicine.drug ,Adult ,medicine.medical_specialty ,Combination therapy ,Anti-HIV Agents ,Immunology ,CD4 Lymphocyte Count ,Delivery, Obstetric ,Gestational Age ,HIV-1 ,Humans ,Infant, Newborn ,Drug Therapy ,antiretroviral therapy ,combination therapy ,epidemiology ,pregnancy ,prematurity ,Premature ,business.industry ,Infant ,Anti-HIV Agent ,Obstetric ,Odds ratio ,Newborn ,medicine.disease ,Surgery ,Pregnancy Complications ,Prospective Studie ,Pregnancy Complications, Infectiou ,Cohort Studie ,business - Abstract
Objective: To assess the association between type and timing of initiation of antiretroviral therapy in pregnancy and duration of pregnancy. Design: Prospective study. Methods: Data on 3920 mother child pairs were examined (3015 mother-child pairs from the European Collaborative Study and 905 from the Swiss Mother + Child HIV Cohort Study). Factors examined included gestational age, antiretroviral therapy during pregnancy, maternal CD4 count, viral load, illicit drug use (IDU) and mode of delivery. Deliveries at less than 37 weeks were defined as premature. Results: The prematurity rate was 17% and median gestational age 39 weeks. Twenty-three per cent (896 of 3920) of women received antiretroviral therapy during pregnancy: 64% (573 of 896) zidovudine monotherapy, 24% (215) combination therapy without protease inhibitors (PI) and 12% (108) combination therapy with PI. In multivariate analysis, adjusted for maternal CD4 count and IDU, odds ratio (OR) of prematurity was 2.60 195% confidence interval (CI), 1.43-4.751 and 1.82 (95% CI, 1.13-2.92) for infants exposed to combination therapy with and without a Pl, respectively, compared to no treatment. Exposure to monotherapy was not associated with prematurity, but severe immunosuppression and IDU in pregnancy were. Women on combination therapy from before pregnancy were twice as likely to deliver prematurely as those starting therapy in the third trimester (OR, 2.17 95% CI, 1.03-4.58). Conclusions: Pregnancy issues should be discussed when making decisions about initiation of combination antiretroviral therapy for HIV-infected women. Elective caesarean section to reduce vertical transmission at 36 weeks rather than 38 weeks may be advisable in women on combination therapy with PI. © 2000 Lippincott Williams & Wilkins.
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- 2000
47. Dynamics of estuarine drift macroalgae: growth cycles and contributions to sediments in shallow areas
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Lanari, M, primary, Kennedy, H, additional, Copertino, MS, additional, Wallner-Kersanach, M, additional, and Claudino, MC, additional
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- 2017
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48. Genetic diversity and patterns of population structure in Creole goats from the Americas
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Ginja, C., primary, Gama, L. T., additional, Martínez, A., additional, Sevane, N., additional, Martin‐Burriel, I., additional, Lanari, M. R., additional, Revidatti, M. A., additional, Aranguren‐Méndez, J. A., additional, Bedotti, D. O., additional, Ribeiro, M. N., additional, Sponenberg, P., additional, Aguirre, E. L., additional, Alvarez‐Franco, L. A., additional, Menezes, M. P. C., additional, Chacón, E., additional, Galarza, A., additional, Gómez‐Urviola, N., additional, Martínez‐López, O. R., additional, Pimenta‐Filho, E. C., additional, da Rocha, L. L., additional, Stemmer, A., additional, Landi, V., additional, and Delgado‐Bermejo, J. V., additional
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- 2017
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49. Distribution of invasive meningococcal B disease in Italian pediatric population: implications for vaccination timing
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Azzari, Chiara, Canessa, Clementina, Lippi, Francesca, Moriondo, Maria, Indolfi, Giuseppe, Nieddu, Francesco, Martini, Marco, de Martino, Maurizio, Castiglia, Paolo, Baldo, Vincenzo, Resti, Massimo, Agostiniani, R., Allievi, P., Allù, G., Amigoni, A., Bartolini, E., Bernardi, Francesco, Bernardini, SOFIA ROBERTA, Biban, P., Bigi, M., Bossi, G., Bottone, U., Cardinale, A., Cardona, A., Castronari, R., Celandroni, A., Chiossi, M., Colleselli, P., Correra, A., Cortimiglia, M., D'Ascola, G., De Benedictis, F. M., de Martino, M., Dini, E., Dollfus, L., Domenici, R., Flacco, V., Verrotti, A., Gaetti, M. T., Gagliardi, L., Galli, Lorenzo, Giglio, P., Guala, A., Lanari, M., Lasagni, D., Lizzoli, C., Lombardi, E., Magnini, M., Mattei, R., Memmini, G., Mesirca, P., Gragnani, S., Migliozzi, L., Nunziata, F., Pecile, P., Pepe, G., Perferi, G., Peris, A., Perri, P. F., Pescollderungg, L., Pezzati, M., Poggi, G. M., Poggiolesi, C., Rapisardi, G., Ratta, L., Ricci, S., Ridi, F., Riva, MARCO ANDREA, Rizzo, L., Roman, B., Romano, F., Toffolo, A., Strano, M., Trapani, S., Valleriani, C., Vasarri, P., Vascotto, M., Vergine, G., Verini, M., Zorzi, C., Azzari, Chiara, Canessa, Clementina, Lippi, Francesca, Moriondo, Maria, Indolfi, Giuseppe, Nieddu, Francesco, Martini, Marco, de Martino, Maurizio, Castiglia, Paolo, Baldo, Vincenzo, Resti, Massimo, Italian Group for the Study of Invasive Bacterial Disease [, Lanari M., and ]
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Pediatrics ,Children ,Incidence ,Neisseria meningitidis group B ,Realtime PCR ,Sensitivity ,Vaccine ,Adolescent ,Age Distribution ,Child ,Child, Preschool ,Hospitals, Pediatric ,Humans ,Immunization Schedule ,Infant ,Infant, Newborn ,Italy ,Meningitis, Meningococcal ,Meningococcal Vaccines ,Real-Time Polymerase Chain Reaction ,Retrospective Studies ,Sepsis ,Neisseria meningitidis, Serogroup B ,Molecular Medicine ,Immunology and Microbiology (all) ,Veterinary (all) ,Public Health, Environmental and Occupational Health ,Infectious Diseases ,Disease ,Neisseria meningitidis ,medicine.disease_cause ,Group B ,Epidemiology ,Medicine ,Pediatric ,Meningococcal ,Incidence (epidemiology) ,Hospitals ,Vaccination ,Public Health ,Meningitis ,medicine.medical_specialty ,Serogroup B ,Immunology and Microbiology(all) ,MED/42 Igiene generale e applicata ,Preschool ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Environmental and Occupational Health ,medicine.disease ,Newborn ,veterinary(all) ,business - Abstract
Neisseria meningitidis group B (MenB) is a leading cause of meningitis and sepsis. A new vaccine has been recently licensed. The aim of the present study was to evaluate the epidemiology of MenB disease in pediatric age and define the optimal age for vaccination. All patients aged 0–18 years admitted with a diagnosis of meningitis or sepsis to the 83 participating Italian pediatric hospitals were included in the study. Blood and/or cerebrospinal fluid (CSF) samples were tested by Realtime-PCR and/or culture. One hundred and thirty-six cases (mean age 5.0 years, median 2.7) of MenB disease were found. Among these, 96/136 (70.6%) were between 0 and 5 years, 61/136 (44.9%) were between 0 and 2 years. Among the latter, 39/61 (63.9%) occurred during the first year of life with highest incidence between 4 and 8 months. A case-fatality rate of 13.2% was found, with 27.8% cases below 12 months. Sepsis lethality was 24.4%. RT-PCR was significantly more sensitive than culture: 82 patients were tested at the same time by both methods, either in blood or in CSF; MenB was found by RT-PCR in blood or CSF in 81/82 cases (98.8%), culture identified 27/82 (32.9%) infections (Cohen's Kappa 0.3; McNemar's: p < 10−5). The study shows that the highest incidence of disease occurs in the first year of age, with a peak between 4 and 8 months of life; 30% of deaths occur before 12 months. The results suggest that the greatest prevention could be obtained starting MenB vaccination in the first months of life; a catch-up strategy up to the fifth year of life could be considered. Our results also confirm that Realtime PCR is significantly more sensitive than culture. In those countries where only isolate positive infections are counted as cases, the incidence of MenB infection results highly underestimated.
- Published
- 2013
50. A rare case of infant sepsis due to the emm-89 genotype of Group A Streptococcus within a community-acquired cluster
- Author
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Pignanelli, S., Brusa, S., Pulcrano, G., Catania, M. R., Enrico Cocchi, Lanari, M., Pignanelli, Salvatore, Brusa, Sandra, Pulcrano, Giovanna, Catania, MARIA ROSARIA, Cocchi, Enrico, Lanari, Marcello, and Catania, Maria Rosaria
- Subjects
Community-Acquired Infections ,Male ,Genotype ,Sepsi ,Streptococcus pyogenes ,Sepsis ,Streptococcal Infections ,Humans ,Infant ,Streptococcus pyogene ,Acute otitis media ,Group A Streptococcu ,emm-89 genotype - Abstract
Invasive Group A Streptococcus disease is a severe and sometimes life-threatening infection with only few cases reported in literature. We describe the case of a 49-day-old male infant with invasive Group A Streptococcus infection characterized by acute otitis media and development of septicemia within a probably community-acquired cluster. The causative agent resulted to be a rare emm-89 genotype of Streptococcus pyogenes. Group A Streptococcus must be considered responsible for sepsis in newborns and young infants.
- Published
- 2015
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