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631 results on '"Laille, A"'

1. The Parenting Program for the Prevention of Child Abuse.

Author

Cleveland Metropolitan General Hospital, OH. and Gabinet, Laille

Abstract

Described is the Parenting Program for the Prevention of Child Abuse which employs home visits to upgrade home environments and to prevent physical abuse of children up to 6 years of age. The program is noted to focus on four major areas: psychological support of the parent; obtaining social services (including health services, educational programs, and financial assistance) that are needed; resolution of inner conflicts which contribute to the danger of child abuse; and parent education in the area of parenting skills. Also explained are factors considered when making referrals to the Parenting Program, specific evaluation and treatment functions, and training of therapists. (SBH)

Published
2024

2. Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)

Author

Rubio-San-Simón, Alba, van Eijkelenburg, Natasha K. A., Hoogendijk, Raoull, Hasle, Henrik, Niemeyer, Charlotte M., Dworzak, Michael N., Zecca, Marco, Lopez-Yurda, Marta, Janssen, Julie M., Huitema, Alwin D. R., van den Heuvel-Eibrink, Marry M., Laille, Eric J., van Tinteren, Harm, and Zwaan, Christian M.

Published
2023
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4. Enasidenib vs conventional care in older patients with late-stage mutant-IDH2 relapsed/refractory AML: a randomized phase 3 trial

Author

de Botton, Stéphane, Montesinos, Pau, Schuh, Andre C., Papayannidis, Cristina, Vyas, Paresh, Wei, Andrew H., Ommen, Hans, Semochkin, Sergey, Kim, Hee-Je, Larson, Richard A., Koprivnikar, Jaime, Frankfurt, Olga, Thol, Felicitas, Chromik, Jörg, Byrne, Jenny, Pigneux, Arnaud, Thomas, Xavier, Salamero, Olga, Vidriales, Maria Belen, Doronin, Vadim, Döhner, Hartmut, Fathi, Amir T., Laille, Eric, Yu, Xin, Hasan, Maroof, Martin-Regueira, Patricia, and DiNardo, Courtney D.

Published
2023
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6. P1408: UPDATED RESULTS OF THE PHASE I BALLI-01 TRIAL OF UCART22, AN ANTI-CD22 ALLOGENEIC CAR-T CELL PRODUCT, IN PATIENTS WITH RELAPSED OR REFRACTORY (R/R) CD22+ B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL)

Author

Nicolas Boissel, Patrice Chevallier, Kevin Curran, Gary Schiller, Hongtau Liu, Richard Larson, Daniel J. Deangelo, Jean-Baptiste Mear, Stephan Grupp, André Baruchel, Marina Konopleva, Alexandra Lacroce, Caroline Roudet, Ana Korngold, Katie Newhall, Eric Laille, Daniel Lee, Mark Frattini, and Nitin Jain

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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7. Malthus y Darwin. Ciencia, educación y formas de vida.

Author

Margarita Hernández Laille

Subjects
Malthus, Darwin, evolución, crisis, educación, Aesthetics of cities. City planning and beautifying, NA9000-9428, Anthropology, GN1-890
Abstract

Este trabajo argumenta que Thomas Robert Malthus, con su An essay on the principle of population (Ensayo sobre el principio de la población), publicado en 1798, y Charles R. Darwin, con la publicación en 1859 de On the origin of species by means of natural selection (El origen de las especies mediante la selección natural), nos previnieron de los riesgos que se avecinaban para la supervivencia de las especies, incluida la especie humana, Homo sapiens, y nos enseñaron con sus criterios educativos que la educación era una herramienta indispensable para llevar una forma de vida que nos alejaría del desastre. Desde que Darwin publicó el Origen de las especies, su teoría fue introducida en las aulas inglesas y poco después se fue enseñando en los distintos países. En España, los conceptos darwinistas se incluyeron por primera vez en un libro de texto de ciencias naturales para la segunda enseñanza en el año 1867 y, a partir de entonces, la enseñanza de la teoría de la evolución fue muy heterogénea. Dado que las ideas de Darwin afectan a todos los campos del saber, tanto científicos como sociales y humanísticos, este artículo propone que su enseñanza se presta a ser implementada con una metodología interdisciplinar y en edades tempranas, para que la población pueda adquirir desde los primeros niveles educativos una visión holística y multidisciplinar de la vida.

Published
2023
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11. Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Von Hoff, Daniel D, Rasco, Drew W, Heath, Elisabeth I, Munster, Pamela N, Schellens, Jan HM, Isambert, Nicolas, Le Tourneau, Christophe, O'Neil, Bert, Mathijssen, Ron HJ, Lopez-Martin, Jose A, Edenfield, W Jeff, Martin, Miguel, LoRusso, Patricia M, Bray, Gordon L, DiMartino, Jorge, Nguyen, Aaron, Liu, Kejian, Laille, Eric, and Bendell, Johanna C

Subjects
Cancer, Clinical Research, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 6.2 Cellular and gene therapies, Aged, Albumins, Antineoplastic Combined Chemotherapy Protocols, Azacitidine, Carboplatin, Disease-Free Survival, Drug Administration Schedule, Female, Humans, Male, Maximum Tolerated Dose, Middle Aged, Neoplasms, Paclitaxel, Treatment Outcome, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Purpose: This large two-part, three-arm phase I study examined the safety and tolerability of CC-486 (an oral formulation of azacitidine, a hypomethylating agent) alone or in combination with the cytotoxic agents, carboplatin or nab-paclitaxel, in patients with advanced unresectable solid tumors.Patients and Methods: Part 1 (n = 57) was a dose escalation of CC-486 alone (arm C) or with carboplatin (arm A) or nab-paclitaxel (arm B). The primary endpoint was safety, MTD, and recommended part 2 dose (RP2D) of CC-486. In part 2 (n = 112), the primary endpoint was the safety and tolerability of CC-486 administered at the RP2D for each treatment arm, in tumor-specific expansion cohorts. Secondary endpoints included pharmacokinetics, pharmacodynamics, and antitumor activity of CC-486.Results: At pharmacologically active doses CC-486 in combination with carboplatin or nab-paclitaxel had a tolerable safety profile and no drug-drug interactions. The CC-486 RP2D was determined as 300 mg (every day, days 1-14/21) in combination with carboplatin (arm A) or as monotherapy (arm C); and 200 mg in the same dosing regimen in combination with nab-paclitaxel (arm B). Albeit limited by the small sample size, CC-486 monotherapy resulted in partial responses (three/eight) and stable disease (four/eight) in patients with nasopharyngeal cancer. Three of the stable disease responses lasted more than 150 days.Conclusions: CC-486 is well tolerated alone or in combination with carboplatin or nab-paclitaxel. Exploratory analyses suggest clinical activity of CC-486 monotherapy in nasopharyngeal cancer and provided the basis for an ongoing phase II clinical trial (ClinicalTrials.gov identifier: NCT02269943). Clin Cancer Res; 24(17); 4072-80. ©2018 AACR.

Published
2018

13. Understanding public administrators’ and citizens’ preferences for a successful transition to pesticide-free urban green spaces

Author

Universidad de Sevilla. Departamento de Análisis Económico y Economía Política, Lefebvre, Marianne, Espinosa Goded, María del Pilar, Maslianskaia-Pautrel, Masha, Laille, Pauline, Universidad de Sevilla. Departamento de Análisis Económico y Economía Política, Lefebvre, Marianne, Espinosa Goded, María del Pilar, Maslianskaia-Pautrel, Masha, and Laille, Pauline

Abstract

Bans on the cosmetic use of pesticides in urban green spaces (UGS) is part of the toolbox to reduce pesticide use. While most technical barriers have been lifted, the acceptability of the global changes induced by pesticide-free UGS management is questioned. Public administrators in charge of UGSs have their own preferences and poorly informed opinions on citizens’ ones. A Discrete Choice Experiment approach was adopted to investigate the discrepancy between the preferences of French citizens and public administrators in charge of technical and budget decisions, in 2017, when the pesticide ban was enforced. Results indicate that the most important differences are in the willingness to improve the working conditions of the maintenance teams, the interest in more natural UGSs and the relevance of communication on the pesticide ban. By challenging some of the opinions of UGS administrators with regard to citizens’ preferences, our results remove some of the barriers to a successful transition toward pesticide-free UGSs.

Published
2024

18. Magic constraints on Gamma-ray emission from Cygnus X-3

Author

Aleksić, J., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Barrio, J. A., Bastieri, D., González, J. Becerra, Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Boller, A., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. De Cea, De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. Delgado, Doert, M., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fonseca, M. V., Font, L., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Göebel, F., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Krähenbühl, T., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paiano, S., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M, Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M, Rügamer, S., Saggion, A., Saito, K., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Torres, D. F., Vankov, H., Wagner, R. M., Weitzel, Q., Zabalza, V., Zandanel, F., Zanin, R., Bulgarelli, A., Max-Moerbeck, W., Piano, G., Pooley, G., Readhead, A. C. S., Richards, J. L., Sabatini, S., Striani, E., Tavani, M., and Trushkin, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Cygnus X-3 is a microquasar consisting of an accreting compact object orbiting around a Wolf-Rayet star. It has been detected at radio frequencies and up to high-energy gamma rays (above 100 MeV). However, many models also predict a very high energy (VHE) emission (above hundreds of GeV) when the source displays relativistic persistent jets or transient ejections. Therefore, detecting such emission would improve the understanding of the jet physics. The imaging atmospheric Cherenkov telescope MAGIC observed Cygnus X-3 for about 70 hours between 2006 March and 2009 August in different X-ray/radio spectral states and also during a period of enhanced gamma-ray emission. MAGIC found no evidence for a VHE signal from the direction of the microquasar. An upper limit to the integral flux for energies higher than 250 GeV has been set to 2.2 x 10-12 photons cm-2 s-1 (95% confidence level). This is the best limit so far to the VHE emission from this source. The non-detection of a VHE signal during the period of activity in the high-energy band sheds light on the location of the possible VHE radiation favoring the emission from the innermost region of the jets, where absorption is significant. The current and future generations of Cherenkov telescopes may detect a signal under precise spectral conditions., Comment: 14 pages, 11 figures, This manuscript has been accepted by ApJ (2010)

Published
2010
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19. MAGIC observation of the GRB080430 afterglow

Author

MAGIC Collaboration, Aleksić, J., Anderhub, H., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Balestra, S., Barrio, J. A., Bastieri, D., González, J. Becerra, Becker, J. K., Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Bock, R. K., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. de Cea, Reyes, R. De los, De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. Delgado, Doert, M., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fernández, E., Firpo, R., Fonseca, M. V., Font, L., Galante, N., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Goebel, F., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Krähenbühl, T., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paoletti, R., Paredes, J. M., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M., Rügamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Strah, N., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Tescaro, D., Teshima, M., Torres, D. F., Turini, N., Vankov, H., Wagner, R. M., Zabalza, V., Zandanel, F., Zanin, R., Zapatero, J., and de Ugarte-Postigo, A.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Context: Gamma-ray bursts are cosmological sources emitting radiation from the gamma-rays to the radio band. Substantial observational efforts have been devoted to the study of gamma-ray bursts during the prompt phase, i.e. the initial burst of high-energy radiation, and during the long-lasting afterglows. In spite of many successes in interpreting these phenomena, there are still several open key questions about the fundamental emission processes, their energetics and the environment. Aim: Independently of specific gamma-ray burst theoretical recipes, spectra in the GeV/TeV range are predicted to be remarkably simple, being satisfactorily modeled with power-laws, and therefore offer a very valuable tool to probe the extragalactic background light distribution. Furthermore, the simple detection of a component at very-high energies, i.e. at $\sim 100$\,GeV, would solve the ambiguity about the importance of various possible emission processes, which provide barely distinguishable scenarios at lower energies. Methods: We used the results of the MAGIC telescope observation of the moderate resdhift ($z\sim0.76$) \object{GRB\,080430} at energies above about 80\,GeV, to evaluate the perspective for late-afterglow observations with ground based GeV/TeV telescopes. Results: We obtained an upper limit of $F_{\rm 95%\,CL} = 5.5 \times 10^{-11}$\,erg\,cm$^{-2}$\,s$^{-1}$ for the very-high energy emission of \object{GRB\,080430}, which cannot set further constraints on the theoretical scenarios proposed for this object also due to the difficulties in modeling the low-energy afterglow. Nonetheless, our observations show that Cherenkov telescopes have already reached the required sensitivity to detect the GeV/TeV emission of GRBs at moderate redshift ($z \lesssim 0.8$), provided the observations are carried out at early times, close to the onset of their afterglow phase., Comment: 6 pages, 1 figure. Astronomy & Astrophysics, in press. Revision affects only the author list.

Published
2010
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20. Search for an extended VHE gamma-ray emission from Mrk 421 and Mrk 501 with the MAGIC Telescope

Author

MAGIC Collaboration, Aleksić, J., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Barrio, J. A., Bastieri, D., González, J. Becerra, Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. De Cea, Reyes, R. De los, De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. Delgado, Doert, M., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fonseca, M. V., Font, L., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Krähenbühl, T., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paiano, S., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M., Rügamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Torres, D. F., Vankov, H., Wagner, R. M., Weitzel, Q., Zabalza, V., Zandanel, F., Zanin, R., Neronov, A., and Semikoz, D. V.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Context: Part of the very high energy $\gamma$-ray radiation coming from extragalactic sources is absorbed through the pair production process on the extragalactic background light photons. Extragalactic magnetic fields alter the trajectories of these cascade pairs and, in turn, convert cosmic background photons to gamma-ray energies by inverse Compton scattering. These secondary photons can form an extended halo around bright VHE sources. Aims: We searched for an extended emission around the bright blazars Mrk 421 and Mrk 501 using the MAGIC telescope data. Methods: If extended emission is present, the angular distribution of reconstructed gamma-ray arrival directions around the source is broader than for a point-like source. In the analysis of a few tens of hours of observational data taken from Mrk 421 and Mrk 501 we used a newly developed method that provides better angular resolution. This method is based on the usage of multidimensional decision trees. Comparing the measured shapes of angular distributions with those expected from a point-like source one can detect or constrain possible extended emission around the source. We also studied the influence of different types of systematic errors on the shape of the distribution of reconstructed gamma-ray arrival directions for a point source. Results: We present upper limits for an extended emission calculated for both sources for various source extensions and emission profiles. We discuss possible constraints on the extragalactic magnetic fields strength. We obtain upper limits on the extended emission around the Mrk~421 (Mrk~501) on the level of < 5% (< 4%) of the Crab Nebula flux above the energy threshold of 300 GeV. Using these results we discuss possible constraints on the extragalactic magnetic fields strength around a few times $10^{-15}$~G., Comment: 8 pages, 9 figures, accepted for publication in A&A

Published
2010
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21. Gamma-ray excess from a stacked sample of high- and intermediate-frequency peaked blazars observed with the MAGIC telescope

Author

MAGIC Collaboration, Aleksić, J., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Barrio, J. A., Bastieri, D., González, J. Becerra, Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Blanch, O., Bock, R. K., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. De Cea, Reyes, R. De los, De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. Delgado, Doert, M., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fonseca, M. V., Font, L., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Krähenbühl, T., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E, Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paiano, S., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M., Rügamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J, Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Tibolla, O., Torres, D. F., Vankov, H., Wagner, R. M., Weitzel, Q., Zabalza, V, Zandanel, F., and Zanin, R.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Between 2004 and 2009 a sample of 28 X-ray selected high- and intermediate-frequency peaked blazars with a X-ray flux larger than 2 uJy at 1 keV in the redshift range from 0.018 to 0.361 was observed with the MAGIC telescope at energies above 100 GeV. Seven among them were detected and the results of these observations are discussed elsewhere. Here we concentrate on the remaining 21 blazars which were not detected during this observation campaign and present the 3 sigma (99.7 %) confidence upper limits on their flux. The individual flux upper limits lie between 1.6 % and 13.6 % of the integral flux from the Crab Nebula. Applying a stacking method to the sample of non-detections with a total of 394.1 hours exposure time, we find evidence for an excess with a cumulative significance of 4.9 standard deviations. It is not dominated by individual objects or flares, but increases linearly with the observation time as for a constant source with an integral flux level of ~1.5 % of that observed from the Crab Nebula above 150 GeV., Comment: 14 pages, 6 figures, accepted by ApJ

Published
2010
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22. MAGIC TeV Gamma-Ray Observations of Markarian 421 during Multiwavelength Campaigns in 2006

Author

MAGIC Collaboration, Aleksić, J., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Balestra, S., Barrio, J. A., Bastieri, D., González, J. Becerra, Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Bock, R. K., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. De Cea, Mendez, C. Delgado, Reyes, R. De los, De Lotto, B., De Maria, M., De Sabata, F., Doert, M., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fonseca, M. V., Font, L., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Krähenbühl, T., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paiano, S., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M., Rügamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Torres, D. F., Vankov, H., Wagner, R. M., Zabalza, V., Zandanel, F., and Zanin, R.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Major Atmospheric Gamma Imaging Cerenkov (MAGIC) telescope participated in three multiwavelength (MWL) campaigns, observing the blazar Markarian (Mkn) 421 during the nights of 2006 April 28, 29, and 2006 June 14. We analyzed the corresponding MAGIC very-high energy observations during 9 nights from 2006 April 22 to 30 and on 2006 June 14. We inferred light curves with sub-day resolution and night-by-night energy spectra. A strong gamma-ray signal was detected from Mkn 421 on all observation nights. The flux (E > 250 GeV) varied on night-by-night basis between (0.92+-0.11)10^-10 cm^-2 s^-1 (0.57 Crab units) and (3.21+-0.15)10^-10 cm^-2 s^-1 (2.0 Crab units) in 2006 April. There is a clear indication for intra-night variability with a doubling time of 36+-10(stat) minutes on the night of 2006 April 29, establishing once more rapid flux variability for this object. For all individual nights gamma-ray spectra could be inferred, with power-law indices ranging from 1.66 to 2.47. We did not find statistically significant correlations between the spectral index and the flux state for individual nights. During the June 2006 campaign, a flux substantially lower than the one measured by the Whipple 10-m telescope four days later was found. Using a log-parabolic power law fit we deduced for some data sets the location of the spectral peak in the very-high energy regime. Our results confirm the indications of rising peak energy with increasing flux, as expected in leptonic acceleration models., Comment: 11 pages, 7 figures, accepted for publication by Astron. Astrophys

Published
2010
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23. Simultaneous multi-frequency observation of the unknown redshift blazar PG 1553+113 in March-April 2008

Author

MAGIC Collaboration, Aleksić, J., Anderhub, H., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Balestra, S., Barrio, J. A., Bastieri, D., González, J. Becerra, Becker, J. K., Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Bock, R. K., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. de Cea, Reyes, R. De los, De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. Delgado, Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fernández, E., Firpo, R., Fonseca, M. V., Font, L., Galante, N., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Goebel, F., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Krähenbühl, T., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paoletti, R., Paredes, J. M., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M., Rügamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Strah, N., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Tescaro, D., Teshima, M., Torres, D. F., Turini, N., Vankov, H., Wagner, R. M., Zabalza, V., Zandanel, F., Zanin, R., Zapatero, J., Pian, E., Bianchin, V., D'Ammando, F., Di Cocco, G., Fugazza, D., Ghisellini, G., Kurtanidze, O. M., Raiteri, C. M., Tosti, G., Treves, A., Vercellone, S., and Villata, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The blazar PG 1553+113 is a well known TeV gamma-ray emitter. In this paper, we determine its spectral energy distribution using simultaneous multi-frequency data in order to study its emission processes. An extensive campaign was carried out between March and April 2008, where optical, X-ray, high-energy (HE) gamma-ray, and very-high-energy (VHE) gamma-ray data were obtained with the KVA, Abastumani, REM, RossiXTE/ASM, AGILE and MAGIC telescopes, respectively. This is the first simultaneous broad-band (i.e., HE+VHE) gamma-ray observation, though AGILE did not detect the source. We combine data to derive source's spectral energy distribution and interpret its double peaked shape within the framework of a synchrotron self compton model, Comment: 5 pages, 2 figures, published

Published
2009
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24. Correlated X-ray and Very High Energy emission in the gamma-ray binary LS I +61 303

Author

The MAGIC Collaboration, Anderhub, H., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Balestra, S., Barrio, J. A., Bastieri, D., González, J. Becerra, Becker, J. K., Bednarek, W., Berger, K., Bernardini, E., Biland, A., Bigas, O. Blanch, Bock, R. K., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. de Cea, Reyes, R. De los, De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. Delgado, Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fernández, E., Firpo, R., Fonseca, M. V., Font, L., Galante, N., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Goebel, F., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paoletti, R., Paredes, J. M., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M., Robert, A., Rügamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schweizer, T., Shayduk, M., Shore, S. N., Sidro, N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Stark, L. S., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Tescaro, D., Teshima, M., Torres, D. F., Turini, N., Vankov, H., Wagner, R. M., Zabalza, V., Zandanel, F., Zanin, R., Zapatero, J., Falcone, A., Vetere, L., Gehrels, N., Trushkin, S., Dhawan, V., and Reig, P.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The discovery of very high energy (VHE) gamma-ray emitting X-ray binaries has triggered an intense effort to better understand the particle acceleration, absorption, and emission mechanisms in compact binary systems, which provide variable conditions along eccentric orbits. Despite this, the nature of some of these systems, and of the accelerated particles producing the VHE emission, is unclear. To answer some of these open questions, we conducted a multiwavelength campaign of the VHE gamma-ray emitting X-ray binary LS I +61 303 including the MAGIC telescope, XMM-Newton, and Swift during 60% of an orbit in 2007 September. We detect a simultaneous outburst at X-ray and VHE bands, with the peak at phase 0.62 and a similar shape at both wavelengths. A linear fit to the simultaneous X-ray/VHE pairs obtained during the outburst yields a correlation coefficient of r=0.97, while a linear fit to all simultaneous pairs provides r=0.81. Since a variable absorption of the VHE emission towards the observer is not expected for the data reported here, the correlation found indicates a simultaneity in the emission processes. Assuming that they are dominated by a single particle population, either hadronic or leptonic, the X-ray/VHE flux ratio favors leptonic models. This fact, together with the detected photon indices, suggests that in LS I +61 303 the X-rays are the result of synchrotron radiation of the same electrons that produce VHE emission as a result of inverse Compton scattering of stellar photons., Comment: To appear in The Astrophysical Journal Letters. 6 pages, 2 figures

Published
2009
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25. MAGIC Gamma-ray Telescope Observation of the Perseus Cluster of Galaxies: implications for cosmic rays, dark matter, and NGC1275

Author

The MAGIC Collaboration, Aleksić, J., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Balestra, S., Barrio, J. A., Bastieri, D., González, J. Becerra, Bednarek, W., Berdyugin, A., Berger, K., Bernardini, E., Biland, A., Bock, R. K., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. De Cea, Reyes, R. De los, De Lotto, B., De Maria, M., De Sabata, F., Mendez, C. Delgado, Doert, M., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fonseca, M. V., Font, L., Galante, N., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Krähenbühl, T., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paiano, S., Paoletti, R., Paredes, J. M., Partini, S., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M., Rügamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Steinke, B., Struebig, J. C., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Torres, D. F., Vankov, H., Wagner, R. M., Zabalza, V., Zandanel, F., Zanin, R., Zapatero, J., Pfrommer, C., Pinzke, A., Enßlin, T. A., Inoue, S., and Ghisellini, G.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Perseus galaxy cluster was observed by the MAGIC Cherenkov telescope for a total effective time of 24.4 hr during 2008 November and December. The resulting upper limits on the gamma-ray emission above 100 GeV are in the range of 4.6 to 7.5 x 10^{-12} cm^{-2} s^{-1} for spectral indices from -1.5 to -2.5, thereby constraining the emission produced by cosmic rays, dark matter annihilations, and the central radio galaxy NGC1275. Results are compatible with cosmological cluster simulations for the cosmic-ray-induced gamma-ray emission, constraining the average cosmic ray-to-thermal pressure to <4% for the cluster core region (<8% for the entire cluster). Using simplified assumptions adopted in earlier work (a power-law spectrum with an index of -2.1, constant cosmic ray-to-thermal pressure for the peripheral cluster regions while accounting for the adiabatic contraction during the cooling flow formation), we would limit the ratio of cosmic ray-to-thermal energy to E_CR/E_th<3%. The upper limit also translates into a level of gamma-ray emission from possible annihilations of the cluster dark matter (the dominant mass component) that is consistent with boost factors of ~10^4 for the typically expected dark matter annihilation-induced emission. Finally, the upper limits obtained for the gamma-ray emission of the central radio galaxy NGC1275 are consistent with the recent detection by the Fermi-LAT satellite. Due to the extremely large Doppler factors required for the jet, a one-zone synchrotron self-Compton model is implausible in this case. We reproduce the observed spectral energy density by using the structured jet (spine-layer) model which has previously been adopted to explain the high-energy emission of radio galaxies., Comment: 15 pages, 5 figures; accepted for publication in ApJ; updated to match the journal final version

Published
2009
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26. MAGIC Collaboration: Contributions to the 31st International Cosmic Ray Conference (ICRC 2009)

Author

The MAGIC Collaboration, Anderhub, H., Antonelli, L. A., Antoranz, P., Backes, M., Baixeras, C., Balestra, S., Barrio, J. A., Bastieri, D., González, J. Becerra, Becker, J. K., Bednarek, W., Berger, K., Bernardini, E., Biland, A., Bock, R. K., Bonnoli, G., Bordas, P., Tridon, D. Borla, Bosch-Ramon, V., Bose, D., Braun, I., Bretz, T., Britzger, D., Camara, M., Carmona, E., Carosi, A., Colin, P., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Covino, S., Dazzi, F., De Angelis, A., del Pozo, E. de Cea, Mendez, C. Delgado, Reyes, R. De los, De Lotto, B., De Maria, M., De Sabata, F., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Elsaesser, D., Errando, M., Ferenc, D., Fernández, E., Firpo, R., Fonseca, M. V., Font, L., Galante, N., López, R. J. García, Garczarczyk, M., Gaug, M., Godinovic, N., Goebel, F., Hadasch, D., Herrero, A., Hildebrand, D., Höhne-Mönch, D., Hose, J., Hrupec, D., Hsu, C. C., Jogler, T., Klepser, S., Kranich, D., La Barbera, A., Laille, A., Leonardo, E., Lindfors, E., Lombardi, S., Longo, F., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Meucci, M., Miranda, J. M., Mirzoyan, R., Miyamoto, H., Moldón, J., Moles, M., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., Orito, R., Oya, I., Paoletti, R., Paredes, J. M., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R. G., Perez-Torres, M. A., Persic, M., Peruzzo, L., Prada, F., Prandini, E., Puchades, N., Puljak, I., Reichardt, I., Rhode, W., Ribó, M., Rico, J., Rissi, M., Robert, A., Rügamer, S., Saggion, A., Saito, T. Y., Salvati, M., Sánchez-Conde, M., Satalecka, K., Scalzotto, V., Scapin, V., Schweizer, T., Shayduk, M., Shore, S. N., Sierpowska-Bartosik, A., Sillanpää, A., Sitarek, J., Sobczynska, D., Spanier, F., Spiro, S., Stamerra, A., Stark, L. S., Suric, T., Takalo, L., Tavecchio, F., Temnikov, P., Tescaro, D., Teshima, M., Torres, D. F., Turini, N., Vankov, H., Wagner, R. M., Zabalza, V., Zandanel, F., Zanin, R., and Zapatero, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Extragalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Index entry listing the contributed papers of the MAGIC collaboration to the 31th International Cosmic Ray Conference (ICRC 2009), July 7-15 2009, \L\'od\'z, Poland. The individual papers are sorted by subject: Overview and Highlight Papers; MAGIC-II Status and Components; Software and Analysis Techniques; Technical Developments; Scientific Results. This HTML document includes clickable links to the papers that exist on the astro-ph arXiv. We hope that this will make it easy to access the MAGIC contributions in a systematic way., Comment: Index of the MAGIC conference proceedings for ICRC 2009. Added 6 papers missing in v1

Published
2009

27. The MAGIC Project: Contributions to ICRC 2007

Author

Albert, J., Aliu, E., Anderhub, H., Antoranz, P., Armada, A., Baixeras, C., Barrio, J. A., Bartko, H., Bastieri, D., Becker, J. K., Bednarek, W., Berger, K., Bigongiari, C., Biland, A., Bock, R. K., Bordas, P., Bosch-Ramon, V., Bretz, T., Britvitch, I., Cabras, G., Camara, M., Carmona, E., Chilingarian, A., Coarasa, J. A., Commichau, S., Contreras, J. L., Cortina, J., Costado, M. T., Curtef, V., Danielyan, V., Dazzi, F., De Angelis, A., Delgado, C., Reyes, R. de los, De Lotto, B., De Maria, M., De Sabata, F., Dorner, D., Doro, M., Errando, M., Fagiolini, M., Ferenc, D., Fernández, E., Firpo, R., Flix, J., Fonseca, M. V., Font, L., Fuchs, M., Galante, N., García-López, R. J., Garczarczyk, M., Gaug, M., Giller, M., Goebel, F., Hakobyan, D., Hayashida, M., Hengstebeck, T., Herrero, A., Höhne, D., Hose, J., Hsu, C. C., Jacon, P., Jogler, T., Kosyra, R., Kranich, D., Kritzer, R., Laille, A., Lindfors, E., Lombardi, S., Longo, F., López, J., López, M., Lorenz, E., Majumdar, P., Maneva, G., Mannheim, K., Mansutti, O., Mariotti, M., Martínez, M., Mazin, D., Merck, C., Meucci, M., Meyer, M., Miranda, J. M., Mirzoyan, R., Mizobuchi, S., Moralejo, A., Nieto, D., Nilsson, K., Ninkovic, J., na-Wilhelmi, E. O, Otte, N., Oya, I., Paneque, D., Paoletti, R., Paredes, J. M., Pasanen, M., Pascoli, D., Pauss, F., Pegna, R., Persic, M., Peruzzo, L., Piccioli, A., Prandini, E., Puchades, N., Raymers, A., Rhode, W., Ribó, M., Rico, J., Rissi, M., Robert, A., Rügamer, S., Saggion, A., Saito, T. Y., Sánchez, A., Sartori, P., Scalzotto, V., Scapin, V., Schmitt, R., Schweizer, T., Shayduk, M., Shinozaki, K., Shore, S. N., Sidro, N., Sillanpää, A., Sobczynska, D., Spanier, F., Stamerra, A., Stark, L. S., Takalo, L., Temnikov, P., Tescaro, D., Teshima, M., Torres, D. F., Turini, N., Vankov, H., Venturini, A., Vitale, V., Wagner, R. M., Wibig, T., Wittek, W., Zandanel, F., Zanin, R., and Zapatero, J.

Subjects
Astrophysics
Abstract

The MAGIC Project: Contributions to ICRC 2007, Merida, Mexico. Contents pages for the Contribution on behalf of the MAGIC Collaboration to the 30th ICRC that took place in July 2007 in Merida, Mexico. The contents are in html form with clickable links to the papers that exist on the Astrophysics archive. We hope that this will make it easier to access the output of the conference in a systematic way. Comments on how useful this is/ how it could be improved should be sent to michela.demaria@iuav.it., Comment: HTML file with clickable links to papers

Published
2007

28. Discovery of VHE gamma-ray emission from 1ES1218+30.4

Author

MAGIC collaboration, Albert, J., Aliu, E., Anderhub, H., Antoranz, P., Armada, A., Asensio, M., Baixeras, C., Barrio, J. A., Bartelt, M., Bartko, H., Bastieri, D., Bavikadi, S. R., Bednarek, W., Berger, K., Bigongiari, C., Biland, A., Bisesi, E., Bock, R. K., Bretz, T., Britvitch, I., Camara, M., Chilingarian, A., Ciprini, S., Coarasa, J. A., Commichau, S., Contreras, J. L., Cortina, J., Curtef, V., Danielyan, V., Dazzi, F., De Angelis, A., Reyes, R. de los, De Lotto, B., Domingo-Santamaria, E., Dorner, D., Doro, M., Errando, M., Fagiolini, M., Ferenc, D., Fernandez, E., Firpo, R., Flix, J., Fonseca, M. V., Font, L., Galante, N., Garczarczyk, M., Gaug, M., Giller, M., Goebel, F., Hakobyan, D., Hayashida, M., Hengstebeck, T., Hoehne, D., Hose, J., Jacon, P., Kalekin, O., Kranich, D., Laille, A., Lenisa, T., Liebing, P., and Lindfors, E.

Subjects
Astrophysics
Abstract

The MAGIC collaboration has studied the high peaked BL-Lac object 1ES1218+30.4 at a redshift z = 0.182, using the MAGIC imaging air Cherenkov telescope located on the Canary island of La Palma. A gamma-ray signal was observed with 6.4sigma significance. The differential energy spectrum for an energy threshold of 120GeV can be fitted by a simple power law yielding F_E(E) = (8.1+-2.1)*10^-7 (E/250GeV)^(-3.0+-0.4) TeV^-1 m^-2 s^-1. During the six days of observation in January 2005 no time variability on time scales of days was found within the statistical errors. The observed integral flux above 350GeV is nearly a factor two below the the upper limit reported by the Whipple Collaboration in 2003., Comment: 5 pages, 4 figures, submitted to ApJ

Published
2006
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29. Flux upper limit of gamma-ray emission by GRB050713a from MAGIC Telescope observations

Author

Albert, J., Aliu, E., Anderhub, H., Antoranz, P., Armada, A., Asensio, M., Baixeras, C., Barrio, J. A., Bartelt, M., Bartko, H., Bastieri, D., Bavikadi, R., Bednarek, W., Berger, K., Bigongiari, C., Biland, A., Bisesi, E., Bock, R. K., Bretz, T., Britvitch, I., Camara, M., Chilingarian, A., Ciprini, S., Coarasa, J. A., Commichau, S., Contreras, J. L., Cortina, J., Curtef, V., Danielyan, V., Dazzi, F., De Angelis, A., Reyes, R. de los, De Lotto, B., Domingo-Santamaria, E., Dorner, D., Doro, M., Errando, M., Fagiolini, M., Ferenc, D., Fernandez, E., Firpo, R., Flix, J., Fonseca, M. V., Font, L., Galante, N., Garczarczyk, M., Gaug, M., Giller, M., Goebel, F., Hakobyan, D., Hayashida, M., Hengstebeck, T., Hohne, D., Hose, J., Jacon, P., Kalekin, O., Kranich, D., Laille, A., Lenisa, T., Liebing, P., Lindfors, E., Longo, F., Lopez, J., Lopez, M., Lorenz, E., Lucarelli, F., Majumdar, P., Maneva, G., Mannheim, K., Mariotti, M., Martinez, M., Mase, K., Mazin, D., Meucci, M., Meyer, M., Miranda, J. M., Mirzoyan, R., Mizobuchi, S., Moralejo, A., Nilsson, K., Ona-Wilhelmi, E., Orduna, R., Otte, N., Oya, I., Paneque, D., Paoletti, R., Pasanen, M., Pascoli, D., Pauss, F., Pavel, N., Pegna, R., Persic, M., Peruzzo, L., Piccioli, A., Prandini, E., Rico, J., Rhode, W., Riegel, B., Rissi, M., Robert, A., Rugamer, S., Saggion, A., Sanchez, A., Sartori, P., Scalzotto, V., Schmitt, R., Schweizer, T., Shayduk, M., Shinozaki, K., Shore, S., Sidro, N., Sillanpaa, A., Sobczynska, D., Stamerra, A., Stark, L. S., Takalo, L., Temnikov, P., Tescaro, D., Teshima, M., Tonello, N., Torres, A., Torres, D. F., Turini, N., Vankov, H., Vardanyan, A., Vitale, V., Wagner, R. M., Wibig, T., Wittek, W., and Zapatero, J.

Subjects
Astrophysics
Abstract

The long-duration GRB050713a was observed by the MAGIC Telescope, 40 seconds after the burst onset, and followed up for 37 minutes, until twilight. The observation, triggered by a SWIFT alert, covered energies above ~175 GeV. Using standard MAGIC analysis, no evidence for a gamma signal was found. As the redshift of the GRB was not measured directly, the flux upper limit, estimated by MAGIC, is still compatible with the assumption of an unbroken power-law spectrum extending from a few hundred keV to our energy range., Comment: 14 pages, 4 figures, submitted to ApJ

Published
2006
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30. P1408: UPDATED RESULTS OF THE PHASE I BALLI-01 TRIAL OF UCART22, AN ANTI-CD22 ALLOGENEIC CAR-T CELL PRODUCT, IN PATIENTS WITH RELAPSED OR REFRACTORY (R/R) CD22+ B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL)

Author

Boissel, Nicolas, primary, Chevallier, Patrice, additional, Curran, Kevin, additional, Schiller, Gary, additional, Liu, Hongtau, additional, Larson, Richard, additional, Deangelo, Daniel J., additional, Mear, Jean-Baptiste, additional, Grupp, Stephan, additional, Baruchel, André, additional, Konopleva, Marina, additional, Lacroce, Alexandra, additional, Roudet, Caroline, additional, Korngold, Ana, additional, Newhall, Katie, additional, Laille, Eric, additional, Lee, Daniel, additional, Frattini, Mark, additional, and Jain, Nitin, additional

Published
2023
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33. Understanding public administrators' and citizens' preferences for a successful transition to pesticide-free urban green spaces.

Author

Lefebvre, Marianne, Espinosa Goded, Maria, Maslianskaia-Pautrel, Masha, and Laille, Pauline

Subjects
CITIZENS, PUBLIC spaces, PESTICIDES, FRENCH people, BUDGET
Abstract

Bans on the cosmetic use of pesticides in urban green spaces (UGS) is part of the toolbox to reduce pesticide use. While most technical barriers have been lifted, the acceptability of the global changes induced by pesticide-free UGS management is questioned. Public administrators in charge of UGSs have their own preferences and poorly informed opinions on citizens' ones. A Discrete Choice Experiment approach was adopted to investigate the discrepancy between the preferences of French citizens and public administrators in charge of technical and budget decisions, in 2017, when the pesticide ban was enforced. Results indicate that the most important differences are in the willingness to improve the working conditions of the maintenance teams, the interest in more natural UGSs and the relevance of communication on the pesticide ban. By challenging some of the opinions of UGS administrators with regard to citizens' preferences, our results remove some of the barriers to a successful transition toward pesticide-free UGSs. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Supplementary Figure 1 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Von Hoff, Daniel D., primary, Rasco, Drew W., primary, Heath, Elisabeth I., primary, Munster, Pamela N., primary, Schellens, Jan H.M., primary, Isambert, Nicolas, primary, Tourneau, Christophe Le, primary, O'Neil, Bert, primary, Mathijssen, Ron H.J., primary, Lopez-Martin, Jose A., primary, Edenfield, W. Jeff, primary, Martin, Miguel, primary, LoRusso, Patricia M., primary, Bray, Gordon L., primary, DiMartino, Jorge, primary, Nguyen, Aaron, primary, Liu, Kejian, primary, Laille, Eric, primary, and Bendell, Johanna C., primary

Published
2023
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36. Supplementary Tables 1-8 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Von Hoff, Daniel D., primary, Rasco, Drew W., primary, Heath, Elisabeth I., primary, Munster, Pamela N., primary, Schellens, Jan H.M., primary, Isambert, Nicolas, primary, Tourneau, Christophe Le, primary, O'Neil, Bert, primary, Mathijssen, Ron H.J., primary, Lopez-Martin, Jose A., primary, Edenfield, W. Jeff, primary, Martin, Miguel, primary, LoRusso, Patricia M., primary, Bray, Gordon L., primary, DiMartino, Jorge, primary, Nguyen, Aaron, primary, Liu, Kejian, primary, Laille, Eric, primary, and Bendell, Johanna C., primary

Published
2023
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37. Supplementary Methods Data from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Von Hoff, Daniel D., primary, Rasco, Drew W., primary, Heath, Elisabeth I., primary, Munster, Pamela N., primary, Schellens, Jan H.M., primary, Isambert, Nicolas, primary, Tourneau, Christophe Le, primary, O'Neil, Bert, primary, Mathijssen, Ron H.J., primary, Lopez-Martin, Jose A., primary, Edenfield, W. Jeff, primary, Martin, Miguel, primary, LoRusso, Patricia M., primary, Bray, Gordon L., primary, DiMartino, Jorge, primary, Nguyen, Aaron, primary, Liu, Kejian, primary, Laille, Eric, primary, and Bendell, Johanna C., primary

Published
2023
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38. Supplementary Figure 3 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Von Hoff, Daniel D., primary, Rasco, Drew W., primary, Heath, Elisabeth I., primary, Munster, Pamela N., primary, Schellens, Jan H.M., primary, Isambert, Nicolas, primary, Tourneau, Christophe Le, primary, O'Neil, Bert, primary, Mathijssen, Ron H.J., primary, Lopez-Martin, Jose A., primary, Edenfield, W. Jeff, primary, Martin, Miguel, primary, LoRusso, Patricia M., primary, Bray, Gordon L., primary, DiMartino, Jorge, primary, Nguyen, Aaron, primary, Liu, Kejian, primary, Laille, Eric, primary, and Bendell, Johanna C., primary

Published
2023
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39. Supplementary Figure 2 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Von Hoff, Daniel D., primary, Rasco, Drew W., primary, Heath, Elisabeth I., primary, Munster, Pamela N., primary, Schellens, Jan H.M., primary, Isambert, Nicolas, primary, Tourneau, Christophe Le, primary, O'Neil, Bert, primary, Mathijssen, Ron H.J., primary, Lopez-Martin, Jose A., primary, Edenfield, W. Jeff, primary, Martin, Miguel, primary, LoRusso, Patricia M., primary, Bray, Gordon L., primary, DiMartino, Jorge, primary, Nguyen, Aaron, primary, Liu, Kejian, primary, Laille, Eric, primary, and Bendell, Johanna C., primary

Published
2023
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40. Enasidenib vs conventional care in older patients with late-stage mutant-IDH2 relapsed/refractory AML: a randomized phase 3 trial

Author

de Botton, S, Montesinos, P, Schuh, AC, Papayannidis, C, Vyas, P, Wei, AH, Ommen, H, Semochkin, S, Kim, H-J, Larson, RA, Koprivnikar, J, Frankfurt, O, Thol, F, Chromik, J, Byrne, J, Pigneux, A, Thomas, X, Salamero, O, Vidriales, MB, Doronin, V, Doehner, H, Fathi, AT, Laille, E, Yu, X, Hasan, M, Martin-Regueira, P, DiNardo, CD, de Botton, S, Montesinos, P, Schuh, AC, Papayannidis, C, Vyas, P, Wei, AH, Ommen, H, Semochkin, S, Kim, H-J, Larson, RA, Koprivnikar, J, Frankfurt, O, Thol, F, Chromik, J, Byrne, J, Pigneux, A, Thomas, X, Salamero, O, Vidriales, MB, Doronin, V, Doehner, H, Fathi, AT, Laille, E, Yu, X, Hasan, M, Martin-Regueira, P, and DiNardo, CD

Abstract

This open-label, randomized, phase 3 trial (NCT02577406) compared enasidenib, an oral IDH2 (isocitrate dehydrogenase 2) inhibitor, with conventional care regimens (CCRs) in patients aged ≥60 years with late-stage, mutant-IDH2 acute myeloid leukemia (AML) relapsed/refractory (R/R) to 2 or 3 prior AML-directed therapies. Patients were first preselected to a CCR (azacitidine, intermediate-dose cytarabine, low-dose cytarabine, or supportive care) and then randomized (1:1) to enasidenib 100 mg per day or CCR. The primary endpoint was overall survival (OS). Secondary endpoints included event-free survival (EFS), time to treatment failure (TTF), overall response rate (ORR), hematologic improvement (HI), and transfusion independence (TI). Overall, 319 patients were randomized to enasidenib (n = 158) or CCR (n = 161). The median age was 71 years, median (range) enasidenib exposure was 142 days (3 to 1270), and CCR was 36 days (1 to 1166). One enasidenib (0.6%) and 20 CCR (12%) patients received no randomized treatment, and 30% and 43%, respectively, received subsequent AML-directed therapies during follow-up. The median OS with enasidenib vs CCR was 6.5 vs 6.2 months (HR [hazard ratio], 0.86; P = .23); 1-year survival was 37.5% vs 26.1%. Enasidenib meaningfully improved EFS (median, 4.9 vs 2.6 months with CCR; HR, 0.68; P = .008), TTF (median, 4.9 vs 1.9 months; HR, 0.53; P < .001), ORR (40.5% vs 9.9%; P <.001), HI (42.4% vs 11.2%), and red blood cell (RBC)-TI (31.7% vs 9.3%). Enasidenib safety was consistent with prior reports. The primary study endpoint was not met, but OS was confounded by early dropout and subsequent AML-directed therapies. Enasidenib provided meaningful benefits in EFS, TTF, ORR, HI, and RBC-TI in this heavily pretreated older mutant-IDH2 R/R AML population.

Published
2023

41. Malthus y Darwin: Ciencia, educación y formas de vida

Author

Hernández Laille, Margarita and Hernández Laille, Margarita

Abstract

Este trabajo argumenta que Thomas Robert Malthus, con su An essay on the principle of population (Ensayo sobre el principio de la población), publicado en 1798, y Charles R. Darwin, con la publicación en 1859 de On the origin of species by means of natural selection (El origen de las especies mediante la selección natural), nos previnieron de los riesgos que se avecinaban para la supervivencia de las especies, incluida la especie humana, Homo sapiens, y nos enseñaron con sus criterios educativos que la educación era una herramienta indispensable para llevar una forma de vida que nos alejaría del desastre. Desde que Darwin publicó el Origen de las especies, su teoría fue introducida en las aulas inglesas y poco después se fue enseñando en los distintos países. En España, los conceptos darwinistas se incluyeron por primera vez en un libro de texto de ciencias naturales para la segunda enseñanza en el año 1867 y, a partir de entonces, la enseñanza de la teoría de la evolución fue muy heterogénea. Dado que las ideas de Darwin afectan a todos los campos del saber, tanto científicos como sociales y humanísticos, este artículo propone que su enseñanza se presta a ser implementada con una metodología interdisciplinar y en edades tempranas, para que la población pueda adquirir desde los primeros niveles educativos una visión holística y multidisciplinar de la vida, This paper argues that Thomas Robert Malthus, with his An essay on the principle of population, published in 1798, and Charles R. Darwin, with the publication in 1859 of On the origin of species by means of natural selection, warned us of the looming risks to the survival of species, including the human species, Homo sapiens. They taught us that education was an indispensable tool to lead a way of life that would keep us away from disaster. From the moment Darwin published the Origin of Species, his theory was introduced into English classrooms and shortly afterwards it was taught in different countries. In Spain, Darwinist concepts were included for the first time in a natural science textbook for the second grade in 1867. From them on, the teaching of the theory of evolution was very heterogeneous. Given that Darwin’s ideas affect all fields of knowledge, both scientific and social and humanistic, this article proposes that his teaching could be implemented with an interdisciplinary methodology and at early ages, so that the population can acquire a holistic and multidisciplinary vision of life from the earliest educational levels., Este artigo argumenta que Thomas Robert Malthus, com seu Ensaio sobre o princípio da população, publicado em 1798, e Charles R. Darwin, com a publicação em 1859 de Sobre a origem das espécies por meio da seleção natural, nos alertaram sobre os riscos iminentes à sobrevivência das espécies, incluindo a espécie humana, Homo sapiens, e nos ensinaram, com seus critérios educacionais, que a educação era uma ferramenta indispensável para levar um estilo de vida que nos manteria longe do desastre. A partir do momento em que Darwin publicou a Origem das Espécies, sua teoria foi introduzida nas salas de aula inglesas e, pouco tempo depois, passou a ser ensinada em diferentes países. Na Espanha, os conceitos darwinistas foram incluídos pela primeira vez em um livro didático de ciências naturais para a segunda série em 1867. A partir de então, o ensino da teoria da evolução foi muito heterogêneo. Considerando que as ideias de Darwin afetam todos os campos do conhecimento, tanto científico quanto social e humanístico, este artigo propõe que seu ensino possa ser implementado com uma metodologia interdisciplinar e desde cedo, para que a população possa adquirir uma visão holística e multidisciplinar da vida desde os primeiros níveis educacionais.

Published
2023

42. Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)

Author

PMC Medisch specialisten, PMC Research, Apotheek O&O&O, Cancer, Speerpunt, Zorg en O&O, Child Health, Rubio-San-Simón, Alba, van Eijkelenburg, Natasha K.A., Hoogendijk, Raoull, Hasle, Henrik, Niemeyer, Charlotte M., Dworzak, Michael N., Zecca, Marco, Lopez-Yurda, Marta, Janssen, Julie M., Huitema, Alwin D.R., van den Heuvel-Eibrink, Marry M., Laille, Eric J., van Tinteren, Harm, Zwaan, Christian M., PMC Medisch specialisten, PMC Research, Apotheek O&O&O, Cancer, Speerpunt, Zorg en O&O, Child Health, Rubio-San-Simón, Alba, van Eijkelenburg, Natasha K.A., Hoogendijk, Raoull, Hasle, Henrik, Niemeyer, Charlotte M., Dworzak, Michael N., Zecca, Marco, Lopez-Yurda, Marta, Janssen, Julie M., Huitema, Alwin D.R., van den Heuvel-Eibrink, Marry M., Laille, Eric J., van Tinteren, Harm, and Zwaan, Christian M.

Published
2023

43. Supplementary Figure 2 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Johanna C. Bendell, Eric Laille, Kejian Liu, Aaron Nguyen, Jorge DiMartino, Gordon L. Bray, Patricia M. LoRusso, Miguel Martin, W. Jeff Edenfield, Jose A. Lopez-Martin, Ron H.J. Mathijssen, Bert O'Neil, Christophe Le Tourneau, Nicolas Isambert, Jan H.M. Schellens, Pamela N. Munster, Elisabeth I. Heath, Drew W. Rasco, and Daniel D. Von Hoff

Abstract

Mean paclitaxel plasma concentrations following nab-paclitaxel administration alone or with CC-486 in part 1 arm B

Published
2023

44. Supplementary Tables 1-8 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Johanna C. Bendell, Eric Laille, Kejian Liu, Aaron Nguyen, Jorge DiMartino, Gordon L. Bray, Patricia M. LoRusso, Miguel Martin, W. Jeff Edenfield, Jose A. Lopez-Martin, Ron H.J. Mathijssen, Bert O'Neil, Christophe Le Tourneau, Nicolas Isambert, Jan H.M. Schellens, Pamela N. Munster, Elisabeth I. Heath, Drew W. Rasco, and Daniel D. Von Hoff

Abstract

Table S1. CC-486 Plus Carboplatin Dose Levels in Part 1 Arm A Table S2. CC-486 Plus nab-Paclitaxel Dose Levels in Part 1 Arm B Table S3. CC-486 Dose Levels in Part 1 Arm C Table S4. Number of Patients With Treatment Emergent Adverse Events for Part 1 Table S5. Number of Patients With Treatment-Emergent Adverse Events in Any Treatment Arm in Part 2 Table S6. Mean CC-486 Plasma Pharmacokinetic Parameters Table S7. Efficacy of CC-486 Alone or in Combination With Carboplatin or nab-Paclitaxel in Part 2 Table S8. Prior Treatment History of NPV Patients

Published
2023

45. Supplementary Figure 1 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Johanna C. Bendell, Eric Laille, Kejian Liu, Aaron Nguyen, Jorge DiMartino, Gordon L. Bray, Patricia M. LoRusso, Miguel Martin, W. Jeff Edenfield, Jose A. Lopez-Martin, Ron H.J. Mathijssen, Bert O'Neil, Christophe Le Tourneau, Nicolas Isambert, Jan H.M. Schellens, Pamela N. Munster, Elisabeth I. Heath, Drew W. Rasco, and Daniel D. Von Hoff

Abstract

Mean total carboplatin plasma concentration following carboplatin administration alone or with CC-486 in part 1 arm A

Published
2023

46. Supplementary Methods Data from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Johanna C. Bendell, Eric Laille, Kejian Liu, Aaron Nguyen, Jorge DiMartino, Gordon L. Bray, Patricia M. LoRusso, Miguel Martin, W. Jeff Edenfield, Jose A. Lopez-Martin, Ron H.J. Mathijssen, Bert O'Neil, Christophe Le Tourneau, Nicolas Isambert, Jan H.M. Schellens, Pamela N. Munster, Elisabeth I. Heath, Drew W. Rasco, and Daniel D. Von Hoff

Abstract

Pharmacodynamic Assessments

Published
2023

47. Supplementary Figure 3 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Johanna C. Bendell, Eric Laille, Kejian Liu, Aaron Nguyen, Jorge DiMartino, Gordon L. Bray, Patricia M. LoRusso, Miguel Martin, W. Jeff Edenfield, Jose A. Lopez-Martin, Ron H.J. Mathijssen, Bert O'Neil, Christophe Le Tourneau, Nicolas Isambert, Jan H.M. Schellens, Pamela N. Munster, Elisabeth I. Heath, Drew W. Rasco, and Daniel D. Von Hoff

Abstract

Correlation analysis between pharmacodynamic and pharmacokinetic findings in part 1

Published
2023

48. Data from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Author

Johanna C. Bendell, Eric Laille, Kejian Liu, Aaron Nguyen, Jorge DiMartino, Gordon L. Bray, Patricia M. LoRusso, Miguel Martin, W. Jeff Edenfield, Jose A. Lopez-Martin, Ron H.J. Mathijssen, Bert O'Neil, Christophe Le Tourneau, Nicolas Isambert, Jan H.M. Schellens, Pamela N. Munster, Elisabeth I. Heath, Drew W. Rasco, and Daniel D. Von Hoff

Abstract

Purpose: This large two-part, three-arm phase I study examined the safety and tolerability of CC-486 (an oral formulation of azacitidine, a hypomethylating agent) alone or in combination with the cytotoxic agents, carboplatin or nab-paclitaxel, in patients with advanced unresectable solid tumors.Patients and Methods: Part 1 (n = 57) was a dose escalation of CC-486 alone (arm C) or with carboplatin (arm A) or nab-paclitaxel (arm B). The primary endpoint was safety, MTD, and recommended part 2 dose (RP2D) of CC-486. In part 2 (n = 112), the primary endpoint was the safety and tolerability of CC-486 administered at the RP2D for each treatment arm, in tumor-specific expansion cohorts. Secondary endpoints included pharmacokinetics, pharmacodynamics, and antitumor activity of CC-486.Results: At pharmacologically active doses CC-486 in combination with carboplatin or nab-paclitaxel had a tolerable safety profile and no drug–drug interactions. The CC-486 RP2D was determined as 300 mg (every day, days 1–14/21) in combination with carboplatin (arm A) or as monotherapy (arm C); and 200 mg in the same dosing regimen in combination with nab-paclitaxel (arm B). Albeit limited by the small sample size, CC-486 monotherapy resulted in partial responses (three/eight) and stable disease (four/eight) in patients with nasopharyngeal cancer. Three of the stable disease responses lasted more than 150 days.Conclusions: CC-486 is well tolerated alone or in combination with carboplatin or nab-paclitaxel. Exploratory analyses suggest clinical activity of CC-486 monotherapy in nasopharyngeal cancer and provided the basis for an ongoing phase II clinical trial (ClinicalTrials.gov identifier: NCT02269943). Clin Cancer Res; 24(17); 4072–80. ©2018 AACR.

Published
2023

50. Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015).

Author

Rubio-San-Simón, Alba, van Eijkelenburg, Natasha K. A., Hoogendijk, Raoull, Hasle, Henrik, Niemeyer, Charlotte M., Dworzak, Michael N., Zecca, Marco, Lopez-Yurda, Marta, Janssen, Julie M., Huitema, Alwin D. R., van den Heuvel-Eibrink, Marry M., Laille, Eric J., van Tinteren, Harm, and Zwaan, Christian M.

Subjects
AZACITIDINE, CHILD patients, HEMATOPOIETIC stem cell transplantation, CONSORTIA, MYELODYSPLASTIC syndromes
Abstract

Background: Advanced myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematological malignancies in children. A second allograft is recommended if a relapse occurs after hematopoietic stem cell transplantation, but the outcome is poor. Objective: We conducted a phase I/II multicenter study to evaluate the safety, pharmacokinetics, and activity of azacitidine in children with relapsed MDS/JMML prior to the second hematopoietic stem cell transplantation. Methods: Patients enrolled from June 2013 to March 2019 received azacitidine intravenously/subcutaneously once daily on days 1–7 of a 28-day cycle. The MDS and JMML cohorts followed a two-stage design separately, with a safety run-in for JMML. Response and safety data were used to evaluate efficacy and establish the recommended dose. Pharmacokinetics was also analyzed. The study closed prematurely because of low recruitment. Results: Six patients with MDS and four patients with JMML received a median of three and five cycles, respectively. Azacitidine 75 mg/m2 was well tolerated and plasma concentration–time profiles were similar to observed in adults. The most prevalent grade 3–4 adverse event was myelotoxicity. No responses were seen in patients with MDS, but 83% achieved stable disease; four patients underwent an allotransplant. Overall response rate in the JMML cohort was 75% (two complete responses; one partial response) and all responders underwent hematopoietic stem cell transplantation. One-year overall survival was 67% (95% confidence interval 38–100) in MDS and 50% (95% confidence interval 19–100) in JMML. Conclusions: Azacitidine 75 mg/m2 prior to a second hematopoietic stem cell transplantation is safe in children with relapsed MDS/JMML. Although the long-term advantage remains to be assessed, this study suggests that azacitidine is an efficacious option for relapsed JMML. Clinical Trial Registration: EudraCT 2010-022235-10. [ABSTRACT FROM AUTHOR]

Published
2023
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