1. ERN1 knockdown modifies the effect of glucose deprivation on homeobox gene expressions in U87 glioma cells
- Author
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Tsymbal Dariia O., Minchenko Dmytro O., Khita Olena O., Rudnytska Olha V., Viletska Yulia M., Lahanovska Yulia O., He Qiuxia, Liu Kechun, and Minchenko Oleksandr H.
- Subjects
ern1 knockdown ,homeobox genes ,mrna expression ,glucose deprivation ,u87 glioma cells ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Objective. The aim of the present investigation was to study the expression of genes encoding homeobox proteins ZEB2 (zinc finger E-box binding homeobox 2), TGIF1 (TGFB induced factor homeobox 1), SPAG4 (sperm associated antigen 4), LHX1 (LIM homeobox 1), LHX2, LHX6, NKX3-1 (NK3 homeobox 1), and PRRX1 (paired related homeobox 1) in U87 glioma cells in response to glucose deprivation in control glioma cells and cells with knockdown of ERN1 (endoplasmic reticulum to nucleus signaling 1), the major pathway of the endoplasmic reticulum stress signaling, for evaluation of it possible significance in the control of glioma growth through ERN1 signaling and chemoresistance.
- Published
- 2020
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