ERN1 knockdown modifies the effect of glucose deprivation on homeobox gene expressions in U87 glioma cells

Authors :: Tsymbal Dariia O.
Minchenko Dmytro O.
Khita Olena O.
Rudnytska Olha V.
Viletska Yulia M.
Lahanovska Yulia O.
He Qiuxia
Liu Kechun
Minchenko Oleksandr H.
Source :: Endocrine Regulations, Vol 54, Iss 3, Pp 196-206 (2020)
Publication Year :: 2020
Publisher :: Sciendo, 2020.
Abstract: Objective. The aim of the present investigation was to study the expression of genes encoding homeobox proteins ZEB2 (zinc finger E-box binding homeobox 2), TGIF1 (TGFB induced factor homeobox 1), SPAG4 (sperm associated antigen 4), LHX1 (LIM homeobox 1), LHX2, LHX6, NKX3-1 (NK3 homeobox 1), and PRRX1 (paired related homeobox 1) in U87 glioma cells in response to glucose deprivation in control glioma cells and cells with knockdown of ERN1 (endoplasmic reticulum to nucleus signaling 1), the major pathway of the endoplasmic reticulum stress signaling, for evaluation of it possible significance in the control of glioma growth through ERN1 signaling and chemoresistance.

Subjects :: ern1 knockdown
homeobox genes
mrna expression
glucose deprivation
u87 glioma cells
Diseases of the endocrine glands. Clinical endocrinology
RC648-665

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