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164 results on '"Lagacé M"'

1. HARNESSING THE PROMISES OF CELL THERAPY, REGENERATIVE MEDICINE, AND GENE THERAPY IN QUÉBEC, CANADA

Author

Delisle, J., primary, Fournier, D., additional, Santerre, K., additional, Rochette, S., additional, Zawati, M.H., additional, Dumont-Lagacé, M., additional, Turcotte, S., additional, Guertin, J.R., additional, Vermette, P., additional, Tremblay, J.P., additional, Parisotto, M., additional, Beauséjour, C., additional, Gélinas, J., additional, Petropoulos, L., additional, and Dieudé, M., additional

Published
2024
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16. In situ SEM Study and Microstructural Evolution of Nano Si anode for Li-ion Technology

Author

Hovington, P., Dontigny, M., Guerfi, A., Trottier, J., Lagacé, M., Mauger, A., M. Julien, C., Zaghib, K., Energy Storage and Conversion, Research Institute of Hydro-Québec, Energy Storage and Conversion, Institut de minéralogie et de physique des milieux condensés (IMPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques (PECSA), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
anode, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], Li-ion, In situ SEM, Nano Si, high energy battery
Abstract

International audience; In situ and ex situ scanning electron microscopy of nano Si and SiO anode particles was carried out during the first cycles, and at various stages of charge. The particle size effects were explored in the range 0.1-20 μm, providing a new insight into the micro-structural evolution of the particles as a function of their size, and into the 'mechanical' resistance upon important volume change upon phase transformation of these anodes. For small particles, the failure of the battery comes from an electrochemical sintering that compacts the whole electrode, which results in its cracking. The particles keep their integrity when the discharge is stopped at a voltage 0.1V, which corresponds to the chemical composition Li12Si7, while the particles are known to crack at deeper discharge up to Li22Si5. Replacing the Si particles by SiO particles in an attempt to avoid these structural effects did not help, because of the different chemical reactions during cycling, with the loss of oxygen. Upon deeper discharge, the particles of size d

Published
2014

17. Treating and Reducing Anxiety and Pain in the Paediatric Emergency Department (The Trapped 2 Survey): Time for Action – A Pediatric Emergency Research Canada (Perc) Project

Author

Trottier, ED, primary, Gravel, J, additional, Ali, S, additional, Meckler, G, additional, Blanchet, M, additional, Stang, A, additional, Porter, R, additional, Lemay, S, additional, Dubrovsky, A S, additional, Chan, M, additional, Jain, R, additional, Principi, T, additional, Joubert, G, additional, Kam, A, additional, Thull-Freedman, J, additional, Neto, G, additional, and Lagacé, M, additional

Published
2016
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19. MP005: Treating and Reducing Anxiety and Pain PEDs (TRAPPED 2): time for action - a PERC project

Author

Trottier, E. D., primary, Ali, S., additional, Meckler, G., additional, Blachet, M., additional, Stang, A.S., additional, Porter, R., additional, Le May, S., additional, Dubrovsky, A., additional, Chan, M., additional, Jain, R., additional, Principi, T., additional, Joubert, G., additional, Kam, A.J., additional, Thull-Freedman, J., additional, Neto, G., additional, Lagacé, M., additional, and Gravel, J., additional

Published
2016
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21. Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson's disease.

Author

Cisbani, G, Drouin-Ouellet, Janelle, Gibrat, C, Saint-Pierre, M, Lagacé, M, Badrinarayanan, S, Lavallée-Bourget, M H, Charest, J, Chabrat, A, Boivin, L, Lebel, M, Bousquet, M, Lévesque, M, Cicchetti, F, Cisbani, G, Drouin-Ouellet, Janelle, Gibrat, C, Saint-Pierre, M, Lagacé, M, Badrinarayanan, S, Lavallée-Bourget, M H, Charest, J, Chabrat, A, Boivin, L, Lebel, M, Bousquet, M, Lévesque, M, and Cicchetti, F

Abstract

The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical trials in Huntington's disease, showing tolerability and benefits on motor symptoms. We tested whether cystamine could have such properties in a Parkinson's disease murine model and now provide evidence that it can not only prevent the neurodegenerative process but also can reverse motor impairments created by a 6-hydroxydopamine lesion 3weeks post-surgery. Importantly, we report that cystamine has neurorestorative properties 5weeks post-lesion as seen on the number of nigral dopaminergic neurons which is comparable with treatments of cysteamine, the reduced form of cystamine used in the clinic, as well as rasagiline, increasingly prescribed in early parkinsonism. All three compounds induced neurite arborization of the remaining dopaminergic cells which was further confirmed in ex vivo dopaminergic explants derived from Pitx3-GFP mice. The disease-modifying effects displayed by cystamine/cysteamine would encourage clinical testing.

Published
2015

22. Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson's disease

Author

Cisbani, G., primary, Drouin-Ouellet, J., additional, Gibrat, C., additional, Saint-Pierre, M., additional, Lagacé, M., additional, Badrinarayanan, S., additional, Lavallée-Bourget, M.H., additional, Charest, J., additional, Chabrat, A., additional, Boivin, L., additional, Lebel, M., additional, Bousquet, M., additional, Lévesque, M., additional, and Cicchetti, F., additional

Published
2015
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42. Shielding self-esteem through the adoption of psychological disengagement mechanisms: the good and the bad news.

Author

Tougas F, Lagacé M, Laplante J, and Bellehumeur C

Abstract

The fact that Canada's working population is aging and will continue to do so is no surprise to anyone. What is surprising though is what many of these aging workers are experiencing in the late years of their career: They continue to be the target of negative stereotypes which in turn, reinforce discrimination and marginalization practices. The present study was aimed at understanding the consequences of differential treatment based on age (measured by relative deprivation) from the theoretical perspective of psychological disengagement. A total of 117 Canadian civil servants over the age of 45 participated in this study. According to hypotheses, it was found that feelings of relative deprivation were associated with discounting which in turn led to a decrease in self-esteem. This chain of reactions generated instabilities, fluctuations in self-esteem and through this, questioned the protective role of psychological disengagement. It is only by devaluing their non-prestigious domain of activity that participants seemed to regain stability of their self-esteem. Theoretical and practical implications of these results are discussed. [ABSTRACT FROM AUTHOR]

Published
2008
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43. A new approach to the link between identity and relative deprivation in the perspective of ageism and retirement.

Author

Tougas F, Lagacé M, de la Sablonnière R, and Kocum L

Abstract

Although the work force is aging, views regarding older workers remain negative. As a result, complaints of discrimination on the basis of age have increased. This situation prompts the following questions: what leads aging workers to acknowledge disparities between younger workers and themselves, and what are the consequences for aging workers of integrating into their self-image some of the characteristics commonly associated with their cohort? These questions are examined in light of a new approach to the link between identity and relative deprivation. The following hypotheses were included in a predictive model: the more individuals include characteristics of their group into their self-descriptions, the more they experience personal deprivation when comparing their own situation to that of younger workers. These feelings, in turn, affect them during retirement in terms of lowered self-esteem and decreased satisfaction with their life. This model was tested among 149 young retirees. Hypotheses were confirmed, and it was shown that end-of-career experiences have an impact on the situation of young [ABSTRACT FROM AUTHOR]

Published
2004
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45. Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s).

Author

Loisel, T P, Ansanay, H, Adam, L, Marullo, S, Seifert, R, Lagacé, M, and Bouvier, M

Abstract

Palmitoylation is unique among lipid modifications in that it is reversible. In recent years, dynamic palmitoylation of G protein alpha subunits and of their cognate receptors has attracted considerable attention. However, very little is known concerning the acylation/deacylation cycle of the proteins in relation to their activity status. In particular, the relative contribution of the activation and desensitization of the signaling unit to the regulation of the receptors and G proteins palmitoylation state is unknown. To address this issue, we took advantage of the fact that a fusion protein composed of the stimulatory alpha subunit of trimeric G protein (Galpha(s)) covalently attached to the beta(2)-adrenergic receptor (beta(2)AR) as a carboxyl-terminal extension (beta(2)AR-Galpha(s)) can be stimulated by agonists but does not undergo rapid inactivation, desensitization, or internalization. When expressed in Sf9 cells, both the receptor and the Galpha(s) moieties of the fusion protein were found to be palmitoylated via thioester linkage. Stimulation with the beta-adrenergic agonist isoproterenol led to a rapid depalmitoylation of both the beta(2)AR and Galpha(s) and inhibited repalmitoylation. The extent of depalmitoylation induced by a series of agonists was correlated (0.99) with their intrinsic efficacy to stimulate the adenylyl cyclase activity. However, forskolin-stimulated cAMP production did not affect the palmitoylation state of beta(2)AR-Galpha(s), indicating that the agonist-promoted depalmitoylation is linked to conformational changes and not to second messenger generation. Given that, upon activation, the fusion protein mimics the activated receptor-G protein complex but cannot undergo desensitization, the data demonstrate that early steps in the activation process lead to the depalmitoylation of both receptor and G protein and that repalmitoylation requires later events that cannot be accommodated by the activated fusion protein.

Published
1999

46. Activity of the carbamyl phosphate synthetase I promoter in liver nuclear extracts is dependent on a cis-acting C/EBP recognition element

Author

Howell, B W, Lagacé, M, and Shore, G C

Abstract

We have identified an essential cis element in the proximal promoter region of the rat carbamyl phosphate synthetase I (CPSI) gene that is requisite for promoter activity in liver nuclear extracts. Excess synthetic oligonucleotides specifying this region abolished promoter-dependent in vitro transcription. We show that C/EBP, a nuclear factor enriched in liver but found as well in other tissues, such as gut, fat, and lung, interacts with an inverted repeat, GTTGCAAC, at the core of the essential cis element. In brain, a tissue that did not express CPSI or contain significant levels of C/EBP, a different factor was capable of binding at or near the C/EBP recognition element. Activity of the CPSI promoter in liver nuclear extracts was also dependent on sequences 5' to the C/EBP motif; presumably, factors binding to elements within this upstream region are instrumental in restricting CPSI gene expression to liver and intestinal mucosa.

Published
1989
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47. Rat carbamyl-phosphate synthetase I gene. Promoter sequence and tissue-specific transcriptional regulation in vitro.

Author

Lagacé, M, Howell, B W, Burak, R, Lusty, C J, and Shore, G C

Abstract

The region flanking the 5'-end of the rat gene encoding the cytoplasmic precursor of carbamyl-phosphate synthetase I, a mitochondrial matrix enzyme, has been cloned and partially characterized. S1 nuclease and primer extension analyses position the starts of transcription 138-140 nucleotides upstream of the translation initiation codon. Exon 1 contains this untranslated sequence and extends downstream to include the coding region for the pre-enzyme signal peptide (38 amino acids) plus 4 amino acids from the amino terminus of the mature protein. The 5'-flanking sequence contains typical promoter elements, including putative TATA and CAAT motifs at −21 and −82 nucleotides, respectively. In addition, several copies of consensus sequences corresponding to the H4TF-1 recognition element, GATTTC, together with the enhancer-like octamer, ATTTGCAT, are also present. Carbamyl-phosphate synthetase I is a cell-type specific enzyme, being expressed only in hepatocytes and epithelial cells of the intestinal mucosa. It is also synthesized at relatively high levels in the hepatoma cell line, Hep G2. Employing pCPS2.1, a minigene containing the promoter and part of exon 1, we show that nuclear extracts from Hep G2 support accurate carbamyl-phosphate synthetase I gene transcription in vitro. No such activity was observed, however, in extracts from HeLa, a cell line which does not express carbamyl-phosphate synthetase I.

Published
1987
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49. Nano-particle Li4Ti5O12 spinel as electrode for electrochemical generators

Author

Guerfi, A., Sévigny, S., Lagacé, M., Hovington, P., Kinoshita, K., and Zaghib, K.

Subjects
*LITHIUM, *NANOPARTICLES, *ELECTROCHEMISTRY
Abstract

Li4Ti5O12 was obtained by solid-state reaction of a ternary precursor mixture, TiO2, Li2CO3 and carbon. The influences of the reaction time, temperature and mixing method on the electrochemical performance of Li4Ti5O12 were investigated. Electrochemical measurements and XRD diffraction characterization were used to determine the reversible capacity and TiO2 residue in the final powder, respectively. Between 1.2 and 2.0 V versus Li, a reversible capacity as high as 165 mAh/g at 7.3 mA/g was obtained. [Copyright &y& Elsevier]

Published
2003
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50. SiO x –graphite as negative for high energy Li-ion batteries

Author

Guerfi, A., Charest, P., Dontigny, M., Trottier, J., Lagacé, M., Hovington, P., Vijh, A., and Zaghib, K.

Subjects
*LITHIUM-ion batteries, *SILICA, *GRAPHITE, *ANODES, *ELECTROCHEMICAL analysis, *SCANNING electron microscopy, *ELECTRIC charge, *BINDING agents
Abstract

Abstract: Negative electrodes containing SiO x were investigated as alternative negative electrodes to carbon for Li-ion batteries. The results obtained on the effect of binders and carbon additives on the electrochemical performance (i.e., reversible capacity, coulombic efficiency, charge–discharge rate capability) of the SiO x –graphite electrode and SiO x electrode are presented. SEM analysis that utilizes facilities for in situ and ex situ studies were applied to better understand the performance and cycle life of the SiO x -based electrodes. The SEM analysis clearly showed that the SiO x particles expand and contract during charge–discharge cycling, and that some of the particles undergo mechanical degradation during this process. The SiO x –graphite electrode with polyimide binder exhibited a stable capacity of 600mAhg−1 during high-rate charge–discharge from C/4 to 1C. These results suggest that the use of a flexible binder like polyimide and reasonably small SiO x particles (nano-particles) facilitates improved cycle life and higher rate capability. [Copyright &y& Elsevier]

Published
2011
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