Search

Your search keyword '"Lacey, Ernest"' showing total 393 results
Start Over Author "Lacey, Ernest"
393 results on '"Lacey, Ernest"'

8. A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor

Author

Dekan, Zoltan, Sianati, Setareh, Yousuf, Arsalan, Sutcliffe, Katy J., Gillis, Alexander, Mallet, Christophe, Singh, Paramjit, Jin, Aihua H., Wang, Anna M., Mohammadi, Sarasa A., Stewart, Michael, Ratnayake, Ranjala, Fontaine, Frank, Lacey, Ernest, Piggott, Andrew M., Du, Yan P., Canals, Meritxell, Sessions, Richard B., Kelly, Eamonn, Capon, Robert J., Alewood, Paul F., and Christ, MacDonald J.

Published
2019

25. Fungal Planet description sheets : 1436 –1477

Author

Tan, Yu Pei, Bishop-Hurley, Sharon L., Shivas, Roger G., Cowan, Don, Maggs-Kölling, Gillian, Maharachchikumbura, Sajeewa S. N., Pinruan, Umpawa, Bransgrove, Kaylene L., De la Peña-Lastra, Saúl, Larsson, Ellen, Lebel, Teresa, Mahadevakumar, Shivannegowda, Mateos, Antonio, Osieck, Eduard R., Rigueiro-Rodríguez, Antonio, Sommai, Sujinda, Ajithkumar, Kadaiah, Akulov, Alex, Anderson, Freda E., Arenas, Francisco, Balashov, Sergey, Bañares, Ángel, Berger, Dave K., Bianchinotti, María V., Bien, Steffen, Bilański, Piotr, Boxshall, Amelia-Grace, Bradshaw, Michael, Broadbridge, Jasmin, Calaça, Francisco J.S., Campos-Quiroz, Carolina, Carrasco-Fernández, Jorge, Castro, Jean F., Chaimongkol, Soravit, Chandranayaka, Siddaiah, Chen, Yanpeng, Comben, David, Dearnaley, John, Ferreira-Sá, Antônio S., Dhileepan, Kunjithapatham, Díaz, Marina L., Divakar, Pradeep K., Xavier-Santos, Solange, Fernández-Bravo, Ana, Gené, Josepa, Guard, Frances E., Guerra, Matías, Gunaseelan, Sugantha, Houbraken, Jos, Janik-Superson, Katarzyna, Jankowiak, Robert, Jeppson, Mikael, Jurjević, Želko, Kaliyaperumal, Malarvizhi, Kelly, Lisa A., Kezo, Kezhocuyi, Khalid, Abdul N., Khamsuntorn, Phongsawat, Kidanemariam, Dawit, Kiran, Munaza, Lacey, Ernest, Langer, Gitta J., López-Llorca, Luis V., Luangsa-ard, Janet J., Lueangjaroenkit, Piyangkun, Lumbsch, H. Thorsten, Maciá-Vicente, Jose G., Mamatha Bhanu, Lakkur S., Marney, Thomas S., Marqués-Gálvez, José E., Morte, Asunción, Naseer, Arooj, Navarro-Ródenas, Alfonso, Oyedele, Oluwawapelumi, Peters, Sandra, Piskorski, Sebastian, Quijada, Luis, Ramírez, Gustavo H., Raja, Kanaga valli, Razzaq, Annum, Rico, Víctor J., Rodríguez, Antonio, Ruszkiewicz-Michalska, Małgorzata, Sánchez, Romina M., Santelices, Cecilia, Savitha, Attihalli S., Serrano, Miguel, Leonardo-Silva, Lucas, Solheim, Halvor, Somrithipol, Sayanh, Sreenivasa, Marikunte Y., Stępniewska, Hanna, Strapagiel, Dominik, Taylor, Tamara, Torres-Garcia, Daniel, Vauras, Jukka, Villarreal, Manuel, Visagie, Cobus M., Wołkowycki, Marek, Yingkunchao, Wittayothin, Zapora, Ewa, Groenewald, Johannes Z., Crous, Pedro W., Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Food and Indoor Mycology, Microbial Ecology (ME), Westerdijk Fungal Biodiversity Institute - Evolutionary Phytopathology, Universidad de Alicante. Departamento de Ciencias del Mar y Biología Aplicada, Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio 'Ramón Margalef', and Fitopatología

Subjects
ITS nrDNA barcodes, LSU, new taxa, systematics, Plantenecologie en Natuurbeheer, Plant Ecology and Nature Conservation, Ecology, Evolution, Behavior and Systematics
Abstract

Novel species of fungi described in this study include those from various countries as follows: Argentina, Colletotrichum araujiae on leaves, stems and fruits of Araujia hortorum. Australia, Agaricus pateritonsus on soil, Curvularia fraserae on dying leaf of Bothriochloa insculpta, Curvularia millisiae from yellowing leaf tips of Cyperus aromaticus, Marasmius brunneolorobustus on well-rotted wood, Nigrospora cooperae from necrotic leaf of Heteropogon contortus, Penicillium tealii from the body of a dead spider, Pseudocercospora robertsiorum from leaf spots of Senna tora, Talaromyces atkinsoniae from gills of Marasmius crinis-equi and Zasmidium pearceae from leaf spots of Smilax glyciphylla. Brazil, Preussia bezerrensis fromair. Chile, Paraconiothyrium kelleni from the rhizosphere of Fragaria chiloensis subsp. chiloensis f. chiloensis. Finland, Inocybe udicola onsoilinmixedforest with Betula pendula, Populus tremula, Picea abies and Alnus incana. France, Myrmecridium normannianum on dead culm of unidentified Poaceae. Germany, Vexillomyces fraxinicola from symptomless stem wood of Fraxinus excelsior. India, Diaporthe limoniae on infected fruit of Limonia acidissima, Didymella naikii on leaves of Cajanus cajan, and Fulvifomes mangroviensis on basal trunk of Aegiceras corniculatum. Indonesia, Penicillium ezekielii from Zea mays kernels. Namibia, Neocamarosporium calicoremae and Neocladosporium calicoremae on stems of Calicorema capitata, and Pleiochaeta adenolobi on symptomatic leaves of Adenolobus pechuelii. Netherlands, Chalara pteridii on stems of Pteridium aquilinum, Neomackenziella juncicola (incl. Neomackenziella gen. nov.)and Sporidesmiella junci from dead culms of Juncus effusus. Pakistan, Inocybe longistipitata on soil in a Quercus forest. Poland, Phytophthora viadrina from rhizosphere soil of Quercus robur, and Septoria krystynae on leaf spots of Viscum album. Portugal (Azores), Acrogenospora stellata on dead wood or bark. South Africa, Phyllactinia greyiae on leaves of Greyia sutherlandii and Punctelia anae on bark of Vachellia karroo. Spain, Anteaglonium lusitanicum on decaying wood of Prunus lusitanica subsp. lusitanica, Hawksworthiomyces riparius from fluvial sediments, Lophiostoma carabassense endophytic in roots of Limbarda crithmoides, and Tuber mohedanoi from calcareussoils. Spain (Canary Islands), Mycena laurisilvae on stumps and woody debris. Sweden, Elaphomyces geminus from soil under Quercus robur. Thailand, Lactifluus chiangraiensis on soil under Pinus merkusii, Lactifluus nakhonphanomensis and Xerocomus sisongkhramensis on soil under Dipterocarpus trees. Ukraine, Valsonectria robiniae on dead twigs of Robinia hispida. USA, Spiralomyces americanus (incl. Spiralomyces gen. nov.) from office air. Morphological and culture characteristics are supported by DNA barcodes.

Published
2022

28. Fungal Planet 1043 – 29 June 2020

Author

Crous, P.W., Wingfield, M.J., Chooi, Y.-H., Gilchrist, C.L.M., Lacey, E., Pitt, J.I., Roets, F., Swart, W.J., Cano-Lira, J.F., Valenzuela-Lopez, N., Hubka, V., Shivas, R.G., Stchigel, A.M., Holdom, D.G., Jurjević, Ž., Kachalkin, A.V., Lebel, T., Lock, C., Martín, M.P., Tan, Y.P., Tomashevskaya, M.A., Vitelli, J.S., Baseia, I.G., Bhatt, V.K., Brandrud, T.E., De Souza, J.T., Dima, B., Lacey, H.J., Lombard, L., Johnston, P.R., Morte, A., Papp, V., Rodríguez, A., Rodríguez-Andrade, E., Semwal, K.C., Tegart, L., Abad, Z.G., Akulov, A., Alvarado, P., Alves, A., Andrade, J.P., Arenas, F., Asenjo, C., Ballarà, J., Barrett, M.D., Berná, L.M., Berraf-Tebbal, A., Bianchinotti, M.V., Bransgrove, K., Burgess, T.I., Carmo, F.S., Chávez, R., Čmoková, A., Dearnaley, J.D.W., de A. Santiago, A.L.C.M., Freitas-Neto, J.F., Denman, S., Douglas, B., Dovana, F., Eichmeier, A., Esteve-Raventós, F., Farid, A., Fedosova, A.G., Ferisin, G., Ferreira, R.J., Ferrer, A., Figueiredo, C.N., Figueiredo, Y.F., Reinoso-Fuentealba, C.G., Garrido-Benavent, I., Cañete-Gibas, C.F., Gil-Durán, C., Glushakova, A.M., Gonçalves, M.F.M., González, M., Gorczak, M., Gorton, C., Guard, F.E., Guarnizo, A.L., Guarro, J., Gutiérrez, M., Hamal, P., Hien, L.T., Hocking, A.D., Houbraken, J., Hunter, G.C., Inácio, C.A., Jourdan, M., Kapitonov, V.I., Kelly, L., Khanh, T.N., Kisło, K., Kiss, L., Kiyashko, A., Kolařík, M., Kruse, J., Kubátová, A., Kučera, V., Kučerová, I., Kušan, I., Lee, H.B., Levicán, G., Lewis, A., Liem, N.V., Liimatainen, K., Lim, H.J., Lyons, M.N., Maciá-Vicente, J.G., Magaña-Dueñas, V., Mahiques, R., Malysheva, E.F., Marbach, P.A.S., Marinho, P., Matočec, N., McTaggart, A.R., Mešić, A., Morin, L., Muñoz-Mohedano, J.M., Navarro-Ródenas, A., Nicolli, C.P., Oliveira, R.L., Otsing, E., Ovrebo, C.L., Pankratov, T.A., Paños, A., Paz-Conde, A., Pérez-Sierra, A., Phosri, C., Pintos, Á., Pošta, A., Prencipe, S., Rubio, E., Saitta, A., Sales, L.S., Sanhueza, L., Shuttleworth, L.A., Smith, J., Smith, M.E., Spadaro, D., Spetik, M., Sochor, M., Sochorová, Z., Sousa, J.O., Suwannasai, N., Tedersoo, L., Thanh, H.M., Thao, L.D., Tkalčec, Z., Vaghefi, N., Venzhik, A.S., Verbeken, A., Vizzini, A., Voyron, S., Wainhouse, M., Whalley, A.J.S., Wrzosek, M., Zapata, M., Zeil-Rolfe, I., Groenewald, J.Z., Crous, Pedro W., Groenewald, Johannes Z., Wingfield, Michael J., Roets, Francois, Swart, Wijnand J., Akulov, Alex, Smith, Jason, Lombard, Lorenzo, Wainhouse, Matt, Douglas, Brian, Denman, Sandra, Johnston, Peter R., Jurjević, Željko, Kolařík, Miroslav, Hubka, Vit, Suwannasai, Nuttika, Martín, María P., Phosri, Cherdchai, Whalley, Anthony J.S., Pitt, John I., Lacey, Ernest, Gilchrist, Cameron L.M., Chooi, Yit-Heng, Figueiredo, Cristiane Nascimento, Sales, Lucas Souza, Andrade, Jackeline Pereira, Figueiredo, Yasmim Freitas, De Souza, Jorge Teodoro, Lacey, Heather J., Hocking, Ailsa D., de L. Oliveira, Renan, Ferreira, Renato J., Lúcio, Paulo Sérgio Marinho, Baseia, Iuri G., Glushakova, Anna M., Tomashevskaya, Maria A., Kachalkin, Aleksey V., Maciá-Vicente, Jose G., Gil-Durán, Carlos, Levicán, Gloria, Chávez, Renato, Sanhueza, Loreto, Ferrer, Alonso, Dima, Bálint, Semwal, Kamal C., Papp, Viktor, Brandrud, Tor Erik, Bhatt, Vinod K., Garrido-Benavent, Isaac, Ballarà, Josep, Liimatainen, Kare, Mahiques, Rafael, Pintos, Ángel, González, Marta, Alvarado, Pablo, Rubio, Enrique, Shuttleworth, Lucas A., Lewis, Alex, Gorton, Caroline, Pérez-Sierra, Ana, Thao, Le Dinh, Hien, Le Thu, Van Liem, Nguyen, Thanh, Ha Minh, Khanh, Tran Ngoc, Saitta, Alessandro, Tedersoo, Leho, Otsing, Eveli, Paz-Conde, Aurelia, Kiss, Levente, Vaghefi, Niloofar, Dearnaley, John D.W., Kelly, Lisa, Bransgrove, Kaylene, Rodríguez-Andrade, Ernesto, Cano-Lira, José F., Stchigel, Alberto M., de Freitas Neto, Julimar F., Sousa, Julieth O., Ovrebo, Clark L., Lee, Hyang Burm, Lim, Hyo Jin, de A. Santiago, André Luiz C.M, Nicolli, Camila Primieri, Carmo, Filipe Sandin, Inácio, Carlos Antonio, Marbach, Phellippe Arthur Santos, Kučera, Viktor, Fedosova, Anna G., Sochorová, Zuzana, Sochor, Michal, Pankratov, Timofey A., Reinoso-Fuentealba, Cintia, Bianchinotti, M. Virginia, Lebel, Teresa, Tegart, Lachlan, Verbeken, Annemieke, Gorczak, Michał, Kisło, Kamil, Wrzosek, Marta, Kruse, Julia, Shivas, Roger G., McTaggart, Alistair R., Lyons, Michael N., Dovana, Francesco, Voyron, Samuele, Vizzini, Alfredo, Ferisin, Giuliano, Raventós, Fernando Esteve, Guard, Frances E., Barrett, Matthew D., Farid, Arian, Smith, Matthew E., Lock, Claire, Vitelli, Joseph S., Holdom, David, Tan, Yu Pei, Kušan, Ivana, Matočec, Neven, Pošta, Ana, Tkalčec, Zdenko, Mešić, Armin, Valenzuela-Lopez, Nicomedes, Guarro, Josep, Čmoková, Adéla, Gonçalves, Micael F.M., Alves, Artur, Spetik, Milan, Berraf-Tebbal, Akila, Eichmeier, Ales, andZcaron, Jurjeviandcacute, eljko, Kučerová, Ivana, Kubátová, Alena, Gibas, Connie F.C., Hamal, Petr, Prencipe, Simona, Spadaro, Davide, Houbraken, Jos, Zapata, Mario, Asenjo, Claudia, Gutiérrez, Mónica, Burgess, Treena I., Abad, Z. Gloria, Kiyashko, Anna, Magaña-Dueñas, Viridiana, Rodríguez, Antonio, Navarro-Ródenas, Alfonso, Arenas, Francisco, Guarnizo, Angel Luigi, Morte, Asunción, Berná, Luis Miguel, Paños, Angela, Muñoz-Mohedano, Justo M., Hunter, Gavin C., Zeil-Rolfe, Isabel, Morin, Louise, Jourdan, Mireille, Venzhik, Aleksandra S., Kapitonov, Vladimir I., and Malysheva, Ekaterina F.

Subjects
ITS nrDNA barcodes, LSU, Fungal Planet description sheets, systematics, new taxa, Research Article
Abstract

Novel species of fungi described in this study include those from various countries as follows: Antarctica, Cladosporium arenosum from marine sediment sand. Argentina, Kosmimatamyces alatophylus (incl. Kosmimatamyces gen. nov.) from soil. Australia, Aspergillus banksianus, Aspergillus kumbius, Aspergillus luteorubrus, Aspergillus malvicolor and Aspergillus nanangensis from soil, Erysiphe medicaginis from leaves of Medicago polymorpha, Hymenotorrendiella communis on leaf litter of Eucalyptus bicostata, Lactifluus albopicri and Lactifluus austropiperatus on soil, Macalpinomyces collinsiae on Eriachne benthamii, Marasmius vagus on soil, Microdochium dawsoniorum from leaves of Sporobolus natalensis, Neopestalotiopsis nebuloides from leaves of Sporobolus elongatus, Pestalotiopsis etonensis from leaves of Sporobolus jacquemontii, Phytophthora personensis from soil associated with dying Grevillea mccutcheonii. Brazil, Aspergillus oxumiae from soil, Calvatia baixaverdensis on soil, Geastrum calycicoriaceum on leaf litter, Greeneria kielmeyerae on leaf spots of Kielmeyera coriacea. Chile, Phytophthora aysenensis on collar rot and stem of Aristotelia chilensis. Croatia, Mollisia gibbospora on fallen branch of Fagus sylvatica. Czech Republic, Neosetophoma hnaniceana from Buxus sempervirens. Ecuador, Exophiala frigidotolerans from soil. Estonia, Elaphomyces bucholtzii in soil. France, Venturia paralias from leaves of Euphorbia paralias. India, Cortinarius balteatoindicus and Cortinarius ulkhagarhiensis on leaf litter. Indonesia, Hymenotorrendiella indonesiana on Eucalyptus urophylla leaf litter. Italy, Penicillium taurinense from indoor chestnut mill. Malaysia, Hemileucoglossum kelabitense on soil, Satchmopsis pini on dead needles of Pinus tecunumanii. Poland, Lecanicillium praecognitum on insects’ frass. Portugal, Neodevriesia aestuarina from saline water. Republic of Korea, Gongronella namwonensis from freshwater. Russia, Candida pellucida from Exomias pellucidus, Heterocephalacria septentrionalis as endophyte from Cladonia rangiferina, Vishniacozyma phoenicis from dates fruit, Volvariella paludosa from swamp. Slovenia, Mallocybe crassivelata on soil. South Africa, Beltraniella podocarpi, Hamatocanthoscypha podocarpi, Coleophoma podocarpi and Nothoseiridium podocarpi (incl. Nothoseiridium gen. nov.) from leaves of Podocarpus latifolius, Gyrothrix encephalarti from leaves of Encephalartos sp., Paraphyton cutaneum from skin of human patient, Phacidiella alsophilae from leaves of Alsophila capensis, and Satchmopsis metrosideri on leaf litter of Metrosideros excelsa. Spain, Cladophialophora cabanerensis from soil, Cortinarius paezii on soil, Cylindrium magnoliae from leaves of Magnolia grandiflora, Trichophoma cylindrospora (incl. Trichophoma gen. nov.) from plant debris, Tuber alcaracense in calcareus soil, Tuber buendiae in calcareus soil. Thailand, Annulohypoxylon spougei on corticated wood, Poaceascoma filiforme from leaves of unknown Poaceae. UK, Dendrostoma luteum on branch lesions of Castanea sativa, Ypsilina buttingtonensis from heartwood of Quercus sp. Ukraine, Myrmecridium phragmiticola from leaves of Phragmites australis. USA, Absidia pararepens from air, Juncomyces californiensis (incl. Juncomyces gen. nov.) from leaves of Juncus effusus, Montagnula cylindrospora from a human skin sample, Muriphila oklahomaensis (incl. Muriphila gen. nov.) on outside wall of alcohol distillery, Neofabraea eucalyptorum from leaves of Eucalyptus macrandra, Diabolocovidia claustri (incl. Diabolocovidia gen. nov.) from leaves of Serenoa repens, Paecilomyces penicilliformis from air, Pseudopezicula betulae from leaves of leaf spots of Populus tremuloides. Vietnam, Diaporthe durionigena on branches of Durio zibethinus and Roridomyces pseudoirritans on rotten wood. Morphological and culture characteristics are supported by DNA barcodes.

Published
2020

34. Dendrillic Acids A and B: Nitrogenous, Rearranged Spongian Nor-Diterpenes from a Dendrillasp. Marine Sponge

Author

Sala, Samuele, James, Patrick J. C., Nealon, Gareth L., Fromont, Jane, Gomez, Oliver, Vuong, Daniel, Lacey, Ernest, and Flematti, Gavin R.

Abstract

Two nitrogenous rearranged spongian nor-diterpenoids, dendrillic acids A and B, were isolated from a marine sponge Dendrillasp. (order: Dendroceratida; family: Darwinellidae). The structures of the metabolites were elucidated on the basis of spectroscopic analysis as well as density functional theory prediction of NMR chemical shifts and application of the DP4+ algorithm. The absolute configuration of the metabolites was established via comparison of experimental and time-dependent density functional theory predicted electronic circular dichroism data. An unusual epimerization reaction was observed leading to the interconversion of the metabolites upon storage in dimethyl sulfoxide solution, which is proposed to proceed via an anionic pathway as probed via isotopic incorporation experiments. Evaluation against a panel of micro-organisms and cell lines revealed that the compounds were devoid of any significant biological activity against all organisms tested, with the exception of mild antiprotozoal activity displayed by dendrillic acid B (2) against Giardia duodenalis.

Published
2023
Full Text
View/download PDF

35. Fuligopyrones from the Fruiting Bodies of Myxomycete Fuligo septicaOffer Short-Term Protection from Abiotic Stress Induced by UV Radiation

Author

Minns, Scott A., Bowles, Simon, Lacey, Ernest, Kalaitzis, John A., Vuong, Daniel, Butler, Mark S., and Piggott, Andrew M.

Abstract

The myxomycete Fuligo septica, colloquially referred to as “dog vomit fungus”, forms vibrant yellow fruiting bodies (aethalia) on wood chips during warm and humid conditions in spring. In 2018, ideal climatic conditions in Sydney, Australia, provided a rare opportunity to access abundant quantities of F. septicaaethalia, which enabled the isolation, purification, structure elucidation, and biological screening of two avenalumamide pyrones, fuligopyrone (1) and fuligopyrone B (2). While 1and 2did not exhibit any appreciable biological activity, their significant UV absorption at 325 nm suggested they may be acting as transient sunscreens to help protect the fruiting mass from exposure to sunlight. In support of this hypothesis, exposing a solution of 2to direct sunlight for 5 min resulted in rapid equilibration with a mixture of 2E,4Z-fuligopyrone B (10) and 2Z,4E-fuligopyrone B (11) photoisomers.

Published
2023
Full Text
View/download PDF

36. Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02870b

Author

Hu, Jinyu, Sarrami, Farzaneh, Li, Hang, Zhang, Guozhi, Stubbs, Keith A., Lacey, Ernest, Stewart, Scott G., Karton, Amir, Piggott, Andrew M., and Chooi, Yit-Heng

Subjects
Chemistry
Abstract

Formation of the three C–C bridges between the two naphthol monomers for elsinochrome (1) involves three distinct classes of oxidases., Perylenequinones are a class of aromatic polyketides characterised by a highly conjugated pentacyclic core, which confers them with potent light-induced bioactivities and unique photophysical properties. Despite the biosynthetic gene clusters for the perylenequinones elsinochrome A (1), cercosporin (4) and hypocrellin A (6) being recently identified, key biosynthetic aspects remain elusive. Here, we first expressed the intact elc gene cluster encoding 1 from the wheat pathogen Parastagonospora nodorum heterologously in Aspergillus nidulans on a yeast-fungal artificial chromosome (YFAC). This led to the identification of a novel flavin-dependent monooxygenase, ElcH, responsible for oxidative enolate coupling of a perylenequinone intermediate to the hexacyclic dihydrobenzo(ghi)perylenequinone in 1. In the absence of ElcH, the perylenequione intermediate formed a hexacyclic cyclohepta(ghi)perylenequinone system via an intramolecular aldol reaction resulting in 6 and a novel hypocrellin 12 with opposite helicity to 1. Theoretical calculations supported that 6 and 12 resulted from atropisomerisation upon formation of the 7-membered ring. Using a bottom-up pathway reconstruction approach on a tripartite YFAC system developed in this study, we uncovered that both a berberine bridge enzyme-like oxidase ElcE and a laccase-like multicopper oxidase ElcG are involved in the double coupling of two naphthol intermediates to form the perylenequinone core. Gene swapping with the homologs from the biosynthetic pathway of 4 showed that cognate pairing of the two classes of oxidases is required for the formation of the perylenequinone core, suggesting the involvement of protein–protein interactions.

Published
2018

39. Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections

Author

Nguyen, Hang, primary, Morshed, Mahmud, additional, Vuong, Daniel, additional, Crombie, Andrew, additional, Lacey, Ernest, additional, Garg, Sanjay, additional, Pi, Hongfei, additional, Woolford, Lucy, additional, Venter, Henrietta, additional, Page, Stephen, additional, Piggott, Andrew, additional, Trott, Darren, additional, and Ogunniyi, Abiodun, additional

Published
2021
Full Text
View/download PDF

41. Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway

Author

Li, Hang, primary, Lacey, Alastair E., additional, Shu, Si, additional, Kalaitzis, John A., additional, Vuong, Daniel, additional, Crombie, Andrew, additional, Hu, Jinyu, additional, Gilchrist, Cameron L. M., additional, Lacey, Ernest, additional, Piggott, Andrew M., additional, and Chooi, Yit-Heng, additional

Published
2021
Full Text
View/download PDF

43. Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia

Author

Emery-Corbin, Samantha J., Hamey, Joshua J., Ansell, Brendan R. E., Balan, Balu, Tichkule, Swapnil, Stroehlein, Andreas J., Cooper, Crystal, McInerney, Bernie, V, Hediyeh-Zadeh, Soroor, Vuong, Daniel, Crombie, Andrew, Lacey, Ernest, Davis, Melissa J., Wilkins, Marc R., Bahlo, Melanie, Svärd, Staffan, Gasser, Robin B., Jex, Aaron R., Emery-Corbin, Samantha J., Hamey, Joshua J., Ansell, Brendan R. E., Balan, Balu, Tichkule, Swapnil, Stroehlein, Andreas J., Cooper, Crystal, McInerney, Bernie, V, Hediyeh-Zadeh, Soroor, Vuong, Daniel, Crombie, Andrew, Lacey, Ernest, Davis, Melissa J., Wilkins, Marc R., Bahlo, Melanie, Svärd, Staffan, Gasser, Robin B., and Jex, Aaron R.

Abstract

Methylation is a common posttranslational modification of arginine and lysine in eukaryotic proteins. Methylproteomes are best characterized for higher eukaryotes, where they are functionally expanded and evolved complex regulation. However, this is not the case for protist species evolved from the earliest eukaryotic lineages. Here, we integrated bioinformatic, proteomic, and drug-screening data sets to comprehensively explore the methylproteome of Giardia duodenalis-a deeply branching parasitic protist. We demonstrate that Giardia and related diplomonads lack arginine-methyltransferases and have remodeled conserved RGG/RG motifs targeted by these enzymes. We also provide experimental evidence for methylarginine absence in proteomes of Giardia but readily detect methyllysine. We bioinformatically infer 11 lysine-methyltransferases in Giardia, including highly diverged Su(var)3-9, Enhancer-of-zeste and Trithorax proteins with reduced domain architectures, and novel annotations demonstrating conserved methyllysine regulation of eukaryotic elongation factor 1 alpha. Using mass spectrometry, we identifymore than 200methyllysine sites in Giardia, including in species-specific gene families involved in cytoskeletal regulation, enriched in coiled-coil features. Finally, we use known methylation inhibitors to show that methylation plays key roles in replication and cyst formation in this parasite. This study highlights reduced methylation enzymes, sites, and functions early in eukaryote evolution, including absent methylarginine networks in the Diplomonadida. These results challenge the view that arginine methylation is eukaryote conserved and demonstrate that functional compensation of methylarginine was possible preceding expansion and diversification of these key networks in higher eukaryotes.

Published
2020
Full Text
View/download PDF

44. Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov

Author

Gilchrist, Cameron L.M., Lacey, Heather J., Vuong, Daniel, Pitt, John I., Lange, Lene, Lacey, Ernest, Pilgaard, Bo, Chooi, Yit Heng, Piggott, Andrew M., Gilchrist, Cameron L.M., Lacey, Heather J., Vuong, Daniel, Pitt, John I., Lange, Lene, Lacey, Ernest, Pilgaard, Bo, Chooi, Yit Heng, and Piggott, Andrew M.

Abstract

Aspergillus burnettii is a new species belonging to the A. alliaceus clade in Aspergillus subgenus Circumdati section Flavi isolated from peanut-growing properties in southern Queensland, Australia. A. burnettii is a fast-growing, floccose fungus with distinctive brown conidia and is a talented producer of biomass-degrading enzymes and secondary metabolites. Chemical profiling of A. burnettii revealed the metabolites ochratoxin A, kotanins, isokotanins, asperlicin E, anominine and paspalinine, which are common to subgenus Circumdati, together with burnettiene A, burnettramic acids, burnettides, and high levels of 14α-hydroxypaspalinine and hirsutide. The genome of A. burnettii was sequenced and an annotated draft genome is presented. A. burnettii is rich in secondary metabolite biosynthetic gene clusters, containing 51 polyketide synthases, 28 non-ribosomal peptide synthetases and 19 genes related to terpene biosynthesis. Functional annotation of digestive enzymes of A. burnettii and A. alliaceus revealed overlapping carbon utilisation profiles, consistent with a close phylogenetic relationship.

Published
2020

45. Fungal planet description sheets : 1042-1111

Author

Crous, Pedro W., Wingfield, Michael J., Chooi, Yit Heng, Gilchrist, Cameron L.M., Lacey, Ernest, Pitt, John I., Roets, Francois, Swart, Wijnand J., Cano-Lira, José F., Valenzuela-Lopez, Nicomedes, Hubka, Vit, Shivas, Roger G., Stchigel, Alberto M., Holdom, David G., Jurjević, Željko, Kachalkin, Aleksey V., Lebel, Teresa, Lock, Claire, Martín, María P., Tan, Yu Pei, Tomashevskaya, Maria A., Vitelli, Joseph S., Baseia, Iuri G., Bhatt, Vinod K., Brandrud, Tor Erik, De Souza, Jorge Teodoro, Dima, Bálint, Lacey, Heather J., Lombard, Lorenzo, Johnston, Peter R., Morte, Asunción, Papp, Viktor, Rodríguez, Antonio, Rodríguez-Andrade, Ernesto, Semwal, Kamal C., Tegart, Lachlan, Abad, Z.G., Akulov, Alex, Alvarado, Pablo, Alves, Artur, Andrade, Jackeline Pereira, Arenas, Francisco, Asenjo, Claudia, Ballarà, Josep, Barrett, Matthew D., Berná, Luis Miguel, Berraf-Tebbal, Akila, Bianchinotti, Virginia, Bransgrove, Kaylene, Maciá-Vicente, Jose G., Crous, Pedro W., Wingfield, Michael J., Chooi, Yit Heng, Gilchrist, Cameron L.M., Lacey, Ernest, Pitt, John I., Roets, Francois, Swart, Wijnand J., Cano-Lira, José F., Valenzuela-Lopez, Nicomedes, Hubka, Vit, Shivas, Roger G., Stchigel, Alberto M., Holdom, David G., Jurjević, Željko, Kachalkin, Aleksey V., Lebel, Teresa, Lock, Claire, Martín, María P., Tan, Yu Pei, Tomashevskaya, Maria A., Vitelli, Joseph S., Baseia, Iuri G., Bhatt, Vinod K., Brandrud, Tor Erik, De Souza, Jorge Teodoro, Dima, Bálint, Lacey, Heather J., Lombard, Lorenzo, Johnston, Peter R., Morte, Asunción, Papp, Viktor, Rodríguez, Antonio, Rodríguez-Andrade, Ernesto, Semwal, Kamal C., Tegart, Lachlan, Abad, Z.G., Akulov, Alex, Alvarado, Pablo, Alves, Artur, Andrade, Jackeline Pereira, Arenas, Francisco, Asenjo, Claudia, Ballarà, Josep, Barrett, Matthew D., Berná, Luis Miguel, Berraf-Tebbal, Akila, Bianchinotti, Virginia, Bransgrove, Kaylene, and Maciá-Vicente, Jose G.

Abstract

Novel species of fungi described in this study include those from various countries as follows: Antarctica, Cladosporium arenosum from marine sediment sand. Argentina, Kosmimatamyces alatophylus (incl. Kosmimatamyces gen. nov.) from soil. Australia, Aspergillus banksianus, Aspergillus kumbius, Aspergillus luteorubrus, Aspergillus malvicolor and Aspergillus nanangensis from soil, Erysiphe medicaginis from leaves of Medicago polymorpha, Hymenotorrendiella communis on leaf litter of Eucalyptus bicostata, Lactifluus albopicri and Lactifluus austropiperatus on soil, Macalpinomyces collinsiae on Eriachne benthamii, Marasmius vagus on soil, Microdochium dawsoniorum from leaves of Sporobolus natalensis, Neopestalotiopsis nebuloides from leaves of Sporobolus elongatus, Pestalotiopsis etonensis from leaves of Sporobolus jacquemontii, Phytophthora personensis from soil associated with dying Grevillea mccutcheonii. Brazil, Aspergillus oxumiae from soil, Calvatia baixaverdensis on soil, Geastrum calycicoriaceum on leaf litter, Greeneria kielmeyerae on leaf spots of Kielmeyera coriacea. Chile, Phytophthora aysenensis on collar rot and stem of Aristotelia chilensis. Croatia, Mollisia gibbospora on fallen branch of Fagus sylvatica. Czech Republic, Neosetophoma hnaniceana from Buxus sempervirens. Ecuador, Exophiala frigidotolerans from soil. Estonia, Elaphomyces bucholtzii in soil. France, Venturia paralias from leaves of Euphorbia paralias. India, Cortinarius balteatoindicus and Cortinarius ulkhagarhiensis on leaf litter. Indonesia, Hymenotorrendiella indonesiana on Eucalyptus urophylla leaf litter. Italy, Penicillium taurinense from indoor chestnut mill. Malaysia, Hemileucoglossum kelabitense on soil, Satchmopsis pini on dead needles of Pinus tecunumanii. Poland, Lecanicillium praecognitum on insects’ frass. Portugal, Neodevriesia aestuarina from saline water. Republic of Korea, Gongronella namwonensis from freshwater. Russia, Candida pellucida from Exomias pellucidus, Heterocepha

Published
2020

50. The isolation and synthesis of novel nematocidal dithiocyanates from an Australian marine sponge, Oceanapia sp

Author

Capon, Robert J., Skene, Colin, Liu, Edward Hsiang-Te, Gill, Jennifer H., Heiland, Kirstin, Friedel, Thomas, and Lacey, Ernest

Subjects
Chemistry, Organic -- Research, Nematocides -- Physiological aspects, Biological assay -- Analysis, Oxygen -- Physiological aspects, Hydrogen -- Physiological aspects, Carbon -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the EtOH extract from the Australian marine sponge, Oceanapia sp. The bioassay-directed fractionation of this extract has been carried out, and the results indicate that it has yielded three dithiocyanates, thiocyanatins A, B and C and their structures have been determined via the spectroscopic analysis.

Published
2001

Catalog

Books, media, physical & digital resources
See catalog results