Search

Your search keyword '"L Weinstein"' showing total 1,637 results
Start Over Author "L Weinstein"

Refine your results

more »

more »

more »

more »

more »
1,637 results on '"L Weinstein"'

1. Safety and Efficacy of Overdilation of 10 mm Viatorr Transjugular Intrahepatic Portosystemic Shunt Stents Using 12 mm Balloons

Author

Muhammad Mohid Tahir, Trevor K. Lewis, Aamir Ali, Michael Hsu, Jeffrey L. Weinstein, Muneeb Ahmed, and Ammar Sarwar

Subjects
portal hypertension, ascites, gastrointestinal bleeding, transjugular intrahepatic portosystemic shunt, stent dilation, hepatic encephalopathy, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Objective The aim of this study was to evaluate overdilation of 10-mm standard and 8–10 mm controlled-expansion Viatorr stents to 12 mm during transjugular intrahepatic portosystemic shunt (TIPS) placement when insufficient reduction (

Published
2024
Full Text
View/download PDF

2. Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men

Author

Haochu Li, Ran Wei, Traci L. Weinstein, Eunsook Kim, Angela J. Jacques-Tiura, Xiaofu Ning, and Wei Ma

Subjects
Nonoccupational post-exposure Prophylaxis (NPEP), Psychometrics, Structural equation modeling, Men who have sex with men, China, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Nonoccupational post-exposure prophylaxis (NPEP) is a short course of medication taken to reduce the likelihood of acquiring human immunodeficiency virus (HIV) infection upon exposure. A review of the literature demonstrates an urgent need for an empirically validated instrument that measures detailed knowledge of NPEP among the key population of men who have sex with men (MSM). Methods Semi-structured interviews, focus groups, and a cross-sectional survey with a sample of 419 MSM was conducted in 2018 in China to develop and psychometrically evaluate the new instrument, the NPEP Knowledge Scale. Exploratory and confirmatory factor analyses, differential item functioning analyses, and structural equation modeling were conducted using Mplus 7.4. Results The NPEP Knowledge Scale demonstrated excellent reliability and validity. Cronbach’s alpha was 0.903. The range of item R2 were 0.527–0.969, p’s

Published
2023
Full Text
View/download PDF

3. Event generators for high-energy physics experiments

Author

J. M. Campbell, M. Diefenthaler, T. J. Hobbs, S. Höche, J. Isaacson, F. Kling, S. Mrenna, J. Reuter, S. Alioli, J. R. Andersen, C. Andreopoulos, A. M. Ankowski, E. C. Aschenauer, A. Ashkenazi, M. D. Baker, J. L. Barrow, M. van Beekveld, G. Bewick, S. Bhattacharya, C. Bierlich, E. Bothmann, P. Bredt, A. Broggio, A. Buckley, A. Butter, J. M. Butterworth, E. P. Byrne, C. M. Carloni-Calame, S. Chakraborty, X. Chen, M. Chiesa, J. T. Childers, J. Cruz-Martinez, J. Currie, N. Darvishi, M. Dasgupta, A. Denner, F. A. Dreyer, S. Dytman, B. K. El-Menoufi, T. Engel, S. Ferrario Ravasio, D. Figueroa, L. Flower, J. R. Forshaw, R. Frederix, A. Friedland, S. Frixione, H. Gallagher, K. Gallmeister, S. Gardiner, R. Gauld, J. Gaunt, A. Gavardi, T. Gehrmann, A. Gehrmann-De Ridder, L. Gellersen, W. Giele, S. Gieseke, F. Giuli, E. W. N. Glover, M. Grazzini, A. Grohsjean, C. Gütschow, K. Hamilton, T. Han, R. Hatcher, G. Heinrich, I. Helenius, O. Hen, V. Hirschi, M. Höfer, J. Holguin, A. Huss, P. Ilten, S. Jadach, A. Jentsch, S. P. Jones, W. Ju, S. Kallweit, A. Karlberg, T. Katori, M. Kerner, W. Kilian, M. M. Kirchgaeßer, S. Klein, M. Knobbe, C. Krause, F. Krauss, J. Lang, J. -N. Lang, G. Lee, S. W. Li, M. A. Lim, J. M. Lindert, D. Lombardi, L. Lönnblad, M. Löschner, N. Lurkin, Y. Ma, P. Machado, V. Magerya, A. Maier, I. Majer, F. Maltoni, M. Marcoli, G. Marinelli, M. R. Masouminia, P. Mastrolia, O. Mattelaer, J. Mazzitelli, J. McFayden, R. Medves, P. Meinzinger, J. Mo, P. F. Monni, G. Montagna, T. Morgan, U. Mosel, B. Nachman, P. Nadolsky, R. Nagar, Z. Nagy, D. Napoletano, P. Nason, T. Neumann, L. J. Nevay, O. Nicrosini, J. Niehues, K. Niewczas, T. Ohl, G. Ossola, V. Pandey, A. Papadopoulou, A. Papaefstathiou, G. Paz, M. Pellen, G. Pelliccioli, T. Peraro, F. Piccinini, L. Pickering, J. Pires, W. Placzek, S. Plätzer, T. Plehn, S. Pozzorini, S. Prestel, C. T. Preuss, A. C. Price, S. Quackenbush, E. Re, D. Reichelt, L. Reina, C. Reuschle, P. Richardson, M. Rocco, N. Rocco, M. Roda, A. Rodriguez Garcia, S. Roiser, J. Rojo, L. Rottoli, G. P. Salam, M. Schönherr, S. Schuchmann, S. Schumann, R. Schürmann, L. Scyboz, M. H. Seymour, F. Siegert, A. Signer, G. Singh Chahal, A. Siódmok, T. Sjöstrand, P. Skands, J. M. Smillie, J. T. Sobczyk, D. Soldin, D. E. Soper, A. Soto-Ontoso, G. Soyez, G. Stagnitto, J. Tena-Vidal, O. Tomalak, F. Tramontano, S. Trojanowski, Z. Tu, S. Uccirati, T. Ullrich, Y. Ulrich, M. Utheim, A. Valassi, A. Verbytskyi, R. Verheyen, M. Wagman, D. Walker, B. R. Webber, L. Weinstein, O. White, J. Whitehead, M. Wiesemann, C. Wilkinson, C. Williams, R. Winterhalder, C. Wret, K. Xie, T-Z. Yang, E. Yazgan, G. Zanderighi, S. Zanoli, K. Zapp

Subjects
Physics, QC1-999
Abstract

We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. Particular emphasis is given to physics models and algorithms that are employed across a variety of experiments. These common themes in event generator development lead to a more comprehensive understanding of physics at the highest energies and intensities, and allow models to be tested against a wealth of data that have been accumulated over the past decades. A cohesive approach to event generator development will allow these models to be further improved and systematic uncertainties to be reduced, directly contributing to future experimental success. Event generators are part of a much larger ecosystem of computational tools. They typically involve a number of unknown model parameters that must be tuned to experimental data, while maintaining the integrity of the underlying physics models. Making both these data, and the analyses with which they have been obtained accessible to future users is an essential aspect of open science and data preservation. It ensures the consistency of physics models across a variety of experiments.

Published
2024
Full Text
View/download PDF

4. A novel role for trithorax in the gene regulatory network for a rapidly evolving fruit fly pigmentation trait.

Author

Michael L Weinstein, Chad M Jaenke, Hasiba Asma, Matthew Spangler, Katherine A Kohnen, Claire C Konys, Melissa E Williams, Ashley V Williams, Mark Rebeiz, Marc S Halfon, and Thomas M Williams

Subjects
Genetics, QH426-470
Abstract

Animal traits develop through the expression and action of numerous regulatory and realizator genes that comprise a gene regulatory network (GRN). For each GRN, its underlying patterns of gene expression are controlled by cis-regulatory elements (CREs) that bind activating and repressing transcription factors. These interactions drive cell-type and developmental stage-specific transcriptional activation or repression. Most GRNs remain incompletely mapped, and a major barrier to this daunting task is CRE identification. Here, we used an in silico method to identify predicted CREs (pCREs) that comprise the GRN which governs sex-specific pigmentation of Drosophila melanogaster. Through in vivo assays, we demonstrate that many pCREs activate expression in the correct cell-type and developmental stage. We employed genome editing to demonstrate that two CREs control the pupal abdomen expression of trithorax, whose function is required for the dimorphic phenotype. Surprisingly, trithorax had no detectable effect on this GRN's key trans-regulators, but shapes the sex-specific expression of two realizator genes. Comparison of sequences orthologous to these CREs supports an evolutionary scenario where these trithorax CREs predated the origin of the dimorphic trait. Collectively, this study demonstrates how in silico approaches can shed novel insights on the GRN basis for a trait's development and evolution.

Published
2023
Full Text
View/download PDF

5. Examining potential effects of non-occupational post-exposure prophylaxis (nPEP) on sexual behaviors of Chinese men who have sex with men: a cross-sectional study

Author

Haochu Li, Ran Wei, Jason J. Ong, Eunsook Kim, Traci L. Weinstein, Xiaofu Ning, and Wei Ma

Subjects
Anticipated behavioral change, Condom use, number of sex partners, Non-occupational post-exposure prophylaxis (nPEP), Men who have sex with men, China, Public aspects of medicine, RA1-1270
Abstract

Abstract Background In China, non-occupational post-exposure prophylaxis (nPEP) is not a conventional service yet and nPEP related studies are very few. Recently, China’s 13th Five Year Action Plan for HIV/AIDS Containment and Prevention examines the feasibility of including nPEP as one of the national strategies for HIV prevention. However, there is a concern that nPEP use might exacerbate high-risk sexual activities. In order to facilitate a research-based policy making of routinizing nPEP services, the current study examined potential effects of nPEP use on condom use and number of sexual partners among Chinese men who have sex with men (MSM) . Methods A cross-sectional survey was conducted in two cities of China in November and December 2018. Descriptive analyses of participants’ sociodemographic and behavioral characteristics were conducted using SPSS 24.0. Mplus 7.4 was used to conduct confirmatory factor analysis and structural equation modeling. Results The sample included 419 Chinese MSM with a mean age of 28.04 (SD = 9.71). Participants reported more positive anticipation of their own behaviors than other MSM’s behaviors regarding condom use and number of sexual partners if nPEP were to be routinized in China. About 60% of participants reported discrepancies between anticipated individual and population behaviors as a potential result of routinization of nPEP services. Anticipated individual behavioral change was positively related to age and duration of residence in the current city, and negatively related to education. Anticipated population behavioral change was positively related to age. Anticipated behavioral discrepancy was positively related to being ethnic minority and never married. Conclusions These findings identify a high-risk subgroup of MSM, who reported they would use condoms less and/or have more sexual partners when nPEP becomes available. This subgroup of MSM might benefit from targeted health interventions. Moreover, there is a clear discrepancy between anticipated individual and population behavioral changes regarding future routinization of nPEP services, suggesting incorporating nPEP services as a means of community development for MSM.

Published
2021
Full Text
View/download PDF

6. Extrahepatic transarterial radioembolization to treat fibrolamellar hepatocellular carcinoma: A case report

Author

Damir Ljuboja, MD, MBA, Jeffrey L Weinstein, MD, FSIR, Muneeb Ahmed, MD, FSIR, and Ammar Sarwar, MD, FSIR

Subjects
Fibrolamellar hepatocellular carcinoma, Extrahepatic, Yttrium-90 radioembolization, TARE, Case report, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare primary liver tumor that typically presents at an advanced stage in early adolescents and adults with no underlying liver disease. Surgical resection is the first-line treatment, and patients who are not surgical candidates face limited treatment options with poor long-term outcomes. Herein we report the first documented, technically successful treatment of FL-HCC with extrahepatic spread using transarterial radioembolization (TARE) in a 16-year-old male patient with surgically unresectable disease. Subsequent imaging revealed tumor necrosis and a 20% reduction in size, and the patient survived 20 months post-treatment, a marked improvement relative to historical data in the literature. Further research should examine the potential role of yttrium-90 TARE in the treatment of FL-HCC patients with metastatic disease.

Published
2020
Full Text
View/download PDF

9. Patient and Provider Perspectives of Telehealth and In-Person Interventional Radiology Clinic Visits

Author

Julie C. Bulman, Fady El-Gabalawy, Luz A. Martinez, Ammar Sarwar, Jeffrey L. Weinstein, Salomao Faintuch, and Muneeb Ahmed

Subjects
Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine
Abstract

To assess patient and provider satisfaction with interventional radiology (IR) outpatient telehealth and in-person clinic.This institutional review board-approved study analyzed patient satisfaction with clinic via survey after an IR outpatient telehealth or in-person visit. A physician telehealth experience survey was completed by 8 IR physicians.During the initial survey period, 44 (83%) of 53 patients completed a survey via telephone compared with 37 (23%) of 158 patients who were offered an electronic survey during the second survey period. Of 81 respondents, 18 (22%) were in-person and 63 (78%) were via telehealth. Of the respondents, nearly all patients (97%) in the telehealth group reported satisfaction with their telehealth clinic visit, with similar rates of high patient satisfaction between in-person and telehealth visits (P = .51). Most patients (98%) in the telehealth group strongly agreed that their physician's recommendations were clear in the telehealth visit and that their visit was private, similar to in-person visits (P = .13). A telehealth visit saved time for all patients (100%), with 78% reporting1 hour of time-saving. All IR physicians (n = 8) reported greater efficiency with telehealth clinic than with in-person clinic and that follow-up patterns would change if telehealth was available. However, all providers (100%) found telephone visits less satisfying than in-person visits, with video visits being either equally satisfying (71%) or less satisfying (29%).Patient satisfaction with the in-person and telehealth outpatient IR clinic was high, with patients and providers reporting time-saving and greater efficiency with telehealth, suggesting that telehealth should remain an important component of outpatient IR clinic care.

Published
2023

11. Epinephrine-induced electrical storm after aortic surgery

Author

Adam L Weinstein, Neal S Gerstein, Josh I Santos, and Peter M Schulman

Subjects
Electric storm, ventricular fibrillation, ventricular tachycardia, Anesthesiology, RD78.3-87.3
Abstract

Electrical storm (ES) is a potentially lethal syndrome defined as three or more sustained episodes of ventricular tachycardia or ventricular fibrillation within 24 h. There are multiple inciting factors for ES, one of which involves excess catecholamine (endogenous and exogenous) effects. Exogenous catecholamines used for hemodynamic support can paradoxically engender or exacerbate an underling arrhythmia leading to ES. We report on an 63-year-old man who presented for repair of an ascending aortic dissection. After cardiopulmonary bypass separation assisted with high-dose epinephrine, ES developed requiring over 40 defibrillatory shocks. The epinephrine infusion was held and within 5 min, the ES self-terminated. ES in the context of cardiovascular surgery with the use of epinephrine for hemodynamic support has not be previously reported. Clinicians need to be cognizant of the seemingly paradoxical effect of epinephrine to induce ES. Initial ES treatment involves acute stabilization (treating or removing exacerbating factors (i.e., excess catecholamines)).

Published
2019
Full Text
View/download PDF

12. Development of a 3D-Printed High Temperature Resin Cecal Fistula Implant for Long-Term and Minimally Invasive Access to the Gut Microbiome

Author

Dulce M. Minaya, Noah L. Weinstein, and Krzysztof Czaja

Subjects
microbiome, microglia, brain, cecum, 3D-printed fistula, fecal transplant, Nutrition. Foods and food supply, TX341-641
Abstract

Microbiota dysbiosis has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological changes affecting the gut-brain neural axis, mental health, and general well-being. However, current animal studies using oral gavage and gnotobiotic animals do not allow for non-invasive long-term access to gut microbiome. The purpose of the present study was to evaluate the feasibility of 3D-printed fistula implants through the body wall and into the cecum of rats to obtain long-term access to gut microbiome. Cecal fistulas were designed and 3D-printed using a high temperature resin (Formlabs; acrylic and methacrylic mixture). Nine male Sprague-Dawley rats underwent the fistula implantation. Food intake, body weight, and body fat were measured to determine the impact of fistula manipulation. Gut microbiome, vagal afferents in the hindbrain, and microglia activation were analyzed to determine if fistula implantation disrupted the gut-brain neural axis. We found that the procedure induced a transient decrease in microbial diversity in the gut that resolved within a few weeks. Fistula implantation had no impact on food intake, body weight, fat mass, or microglia activation. Our study shows that 3D-printed cecal fistula implantation is an effective procedure that allows long-term and minimally invasive access to gut microbiome.

Published
2021
Full Text
View/download PDF

13. An aggregate approach to estimating quality of life in micropolitan areas

Author

Amanda L. Weinstein, Michael Hicks, and Emily Wornell

Subjects
General Social Sciences, General Environmental Science
Abstract

Because of their reliance on large samples of micro-level housing and wage data, quality of life studies using Rosen–Roback models have focused almost exclusively on metropolitan areas, largely ignoring non-metropolitan areas. Although understandable given data constraints, this dominant focus on metropolitans has limited the data-driven approaches available to policymakers concerned with community and economic development in small cities, or micropolitan areas. To address this gap, we develop an aggregate approach to estimate both quality of life and quality of the business environment in micropolitan areas utilizing county-level housing and wage data that can be used when large samples of micro-level data are unavailable. Specifically, we use the county residuals from wage and housing regressions to replace the fixed effects typically estimated from the micro-level estimations in quality of life studies. We find compelling evidence that higher quality of life is not only associated with higher employment and population growth and lower poverty rates, but that it is more important than quality of the business environment in determining the success of micropolitan areas.

Published
2022

14. Echocardiographic and Other Preprocedural Predictors of Heart Failure After TIPS Placement in Patients With Cirrhosis: A Single-Center 15-Year Analysis

Author

Aamir, Ali, Ammar, Sarwar, Vilas R, Patwardhan, Ariane M, Fraiche, Muhammad M, Tahir, Michael, Luo, Jeffrey L, Weinstein, Muhammad Sarib, Hussain, Michael P, Curry, and Muneeb, Ahmed

Subjects
Heart Failure, Liver Cirrhosis, Male, Echocardiography, Humans, Female, Stroke Volume, Radiology, Nuclear Medicine and imaging, General Medicine, Middle Aged, Prognosis, Ventricular Function, Left, Retrospective Studies
Published
2022

18. Detector requirements and simulation results for the EIC exclusive, diffractive and tagging physics program using the ECCE detector concept

Author

A. Bylinkin, C.T. Dean, S. Fegan, D. Gangadharan, K. Gates, S.J.D. Kay, I. Korover, W.B. Li, X. Li, R. Montgomery, D. Nguyen, G. Penman, J.R. Pybus, N. Santiesteban, S. Shimizu, R. Trotta, A. Usman, M.D. Baker, J. Frantz, D.I. Glazier, D.W. Higinbotham, T. Horn, J. Huang, G.M. Huber, R. Reed, J. Roche, A. Schmidt, P. Steinberg, J. Stevens, Y. Goto, C. Munoz Camacho, M. Murray, Z. Papandreou, W. Zha, J.K. Adkins, Y. Akiba, A. Albataineh, M. Amaryan, I.C. Arsene, C. Ayerbe Gayoso, J. Bae, X. Bai, M. Bashkanov, R. Bellwied, F. Benmokhtar, V. Berdnikov, J.C. Bernauer, F. Bock, W. Boeglin, M. Borysova, E. Brash, P. Brindza, W.J. Briscoe, M. Brooks, S. Bueltmann, M.H.S. Bukhari, R. Capobianco, W.-C. Chang, Y. Cheon, K. Chen, K.-F. Chen, K.-Y. Cheng, M. Chiu, T. Chujo, Z. Citron, E. Cline, E. Cohen, T. Cormier, Y. Corrales Morales, C. Cotton, J. Crafts, C. Crawford, S. Creekmore, C. Cuevas, J. Cunningham, G. David, M. Demarteau, S. Diehl, N. Doshita, R. Dupré, J.M. Durham, R. Dzhygadlo, R. Ehlers, L. El Fassi, A. Emmert, R. Ent, C. Fanelli, R. Fatemi, M. Finger, M. Friedman, I. Friscic, S. Gardner, F. Geurts, R. Gilman, E. Glimos, N. Grau, S.V. Greene, A.Q. Guo, L. Guo, S.K. Ha, J. Haggerty, T. Hayward, X. He, O. Hen, M. Hoballah, A. Hoghmrtsyan, P.-h.J. Hsu, A. Hutson, K.Y. Hwang, C.E. Hyde, M. Inaba, T. Iwata, H.S. Jo, K. Joo, N. Kalantarians, G. Kalicy, K. Kawade, A. Kim, B. Kim, C. Kim, M. Kim, Y. Kim, E. Kistenev, V. Klimenko, S.H. Ko, W. Korsch, G. Krintiras, S. Kuhn, C.-M. Kuo, T. Kutz, J. Lajoie, D. Lawrence, S. Lebedev, H. Lee, J.S.H. Lee, S.W. Lee, Y.-J. Lee, W. Li, Y.T. Liang, S. Lim, C.-h. Lin, D.X. Lin, K. Liu, M.X. Liu, K. Livingston, N. Liyanage, W.J. Llope, C. Loizides, E. Long, R.-S. Lu, Z. Lu, W. Lynch, S. Mantry, D. Marchand, M. Marcisovsky, C. Markert, P. Markowitz, H. Marukyan, P. McGaughey, M. Mihovilovic, R.G. Milner, A. Milov, Y. Miyachi, A. Mkrtchyan, P. Monaghan, D. Morrison, A. Movsisyan, H. Mkrtchyan, K. Nagai, J. Nagle, I. Nakagawa, C. Nattrass, S. Niccolai, R. Nouicer, G. Nukazuka, M. Nycz, V.A. Okorokov, S. Orešić, J.D. Osborn, C. O’Shaughnessy, S. Paganis, S.F. Pate, M. Patel, C. Paus, M.G. Perdekamp, D.V. Perepelitsa, H. Periera da Costa, K. Peters, W. Phelps, E. Piasetzky, C. Pinkenburg, I. Prochazka, T. Protzman, M.L. Purschke, J. Putschke, R. Rajput-Ghoshal, J. Rasson, B. Raue, K.F. Read, K. Røed, J. Reinhold, E.L. Renner, J. Richards, C. Riedl, T. Rinn, G.M. Roland, G. Ron, M. Rosati, C. Royon, J. Ryu, S. Salur, R. Santos, M. Sarsour, J. Schambach, N. Schmidt, C. Schwarz, J. Schwiening, R. Seidl, A. Sickles, P. Simmerling, S. Sirca, D. Sharma, Z. Shi, T.-A. Shibata, C.-W. Shih, U. Shrestha, K. Slifer, K. Smith, D. Sokhan, R. Soltz, W. Sondheim, J. Song, I.I. Strakovsky, P. Stepanov, J. Strube, P. Sun, X. Sun, K. Suresh, V. Tadevosyan, W.-C. Tang, S. Tapia Araya, S. Tarafdar, L. Teodorescu, D. Thomas, A. Timmins, L. Tomasek, N. Trotta, T.S. Tveter, E. Umaka, H.W. van Hecke, C. Van Hulse, J. Velkovska, E. Voutier, P.K. Wang, Q. Wang, Y. Wang, D.P. Watts, N. Wickramaarachchi, L. Weinstein, M. Williams, C.-P. Wong, L. Wood, M.H. Wood, C. Woody, B. Wyslouch, Z. Xiao, Y. Yamazaki, Y. Yang, Z. Ye, H.D. Yoo, M. Yurov, N. Zachariou, W.A. Zajc, J.-L. Zhang, J.-X. Zhang, Y. Zhang, Y.-X. Zhao, X. Zheng, P. Zhuang, HEP, INSPIRE, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, detector: performance, [PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], nucleon: structure, diffraction, FOS: Physical sciences, tagging, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], ion: beam, Diffractive, exclusive, EIC, Tagging, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment (nucl-ex), electron–ion collider, Instrumentation, Nuclear Experiment, detector: design, quark gluon, nucleus, Electron Ion Collider, Instrumentation and Detectors (physics.ins-det), experimental equipment, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], diffractive, Exclusive, vertex: primary, ECCE, technology: proposed
Abstract

The version of this article on this repository is an arXiv preprint (arXiv:2208.14575v2 [physics.ins-det] Mon, 6 Mar 2023 19:46:42 UTC (39,794 KB)) submitted to Elsevier and is not the final, peer reviewed, corrected article. It is made available under a Creative Commons (CC BY 4.0) Attribution License. This article presents a collection of simulation studies using the ECCE detector concept in the context of the EIC's exclusive, diffractive, and tagging physics program, which aims to further explore the rich quark–gluon structure of nucleons and nuclei. To successfully execute the program, ECCE proposed to utilize the detector system close to the beamline to ensure exclusivity and tag ion beam/fragments for a particular reaction of interest. Preliminary studies confirm the proposed technology and design satisfy the requirements. The projected physics impact results are based on the projected detector performance from the simulation at 10 or 100 fb−1 of integrated luminosity. Additionally, insights related to a potential second EIC detector are documented, which could serve as a guidepost for future development. Office of Nuclear Physics in the Office of Science in the Department of Energy, the National Science Foundation, USA, the Los Alamos National Laboratory Directed Research and Development (LDRD), USA 20200022DR, the Natural Sciences and Engineering Research Council of Canada (NSERC), and the UK Research and Innovation Science and Technology Facilities Council; This research used resources from the Compute and Data Environment for Science (CADES) at the Oak Ridge National Laboratory, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC05-00OR22725; Brookhaven National Lab and the Thomas Jefferson National Accelerator Facility which are operated under contracts DE-SC0012704 and DE-AC05-06OR23177 respectively.

Published
2023

20. The Present and Future of QCD: QCD Town Meeting White Paper -- An INput to the 2023 NSAC Long Range Plan

Author

P Achenbach, D Adhikari, A Afanasev, F Afzal, C Aidala, A Al-bataineh, D Almaaloi, M Amaryan, D Androic, W Armstrong, M Arriatia, J Arrington, A Asaturyan, E Aschenauer, H Atac, H Avakian, T Averett, C Ayerbe Gayoso, X Bai, K Barish, N Barnea, G Basar, M Battaglieri, A Baty, I Bautista, A Bazilevsky, C Beattie, S Behera, V Bellini, R Bellwied, J Benesch, F Benmokhtar, C Bernardes, J Bernauer, H Bhatt, S Bhatta, M Boer, T Boettcher, S Bogacz, H Bossi, J Brandenburg, E Brash, R Briceno, W Briscoe, S Brodsky, D Brown, V Burkert, H Caines, I Cali, A Camsonne, D Carman, J Caylor, S Cerci, M Chamizo Llatas, J Chen, Y Chen, Y Chien, P Chou, X Chu, E Chudakov, E Cline, I Cloet, P Cole, M Conners, M Constantinou, W Cosyn, S Covrig Dusa, R Cruz-Torres, U D'Alesio, C da Silva, Z Davoudi, C Dean, D Dean, M Demarteau, A Deshpande, W Detmold, A Deur, B Devkota, S Dhital, M Diefenthaler, S Dobbs, M Doring, X Dong, R Dotel, K Dow, E Downie, J Drachenberg, A Dumitru, J Dunlop, R Dupre, J Durham, D Dutta, R Edwards, R Ehlers, L El Fassi, M Elaasar, L Elouadrhiri, M Engelhardt, R Ent, S Esumi, O Evdokimov, O Eyser, C Fanelli, R Fatemi, I Fernando, F Flor, N Fomin, A Frawley, T Federico, R Fries, C Gal, B Gamage, L Gamberg, H Gao, D Gaskell, F Geurts, Y Ghandilyan, R Gilman, C Gleason, K Gnanvo, R Gothe, S Greene, H Griesshammer, S Grossberndt, B Grube, D Hackett, T Hague, H Hakobyan, J Hansen, Y Hatta, M Hattawy, L Havener, O Hen, W Henry, D Higinbotham, T Hobbs, A Hodges, T Holmstrom, B Hong, T Horn, C Howell, H Huang, M Huang, S Huang, G Huber, C Hyde, E Isupov, P Jacobs, J Jalilian-Marian, A Jentsch, H Jheng, C Ji, X Ji, J Jia, D Jones, M Jones, N Kalantarians, G Kalicy, Z Kang, J Karthein, D Keller, C Keppel, V Khachartryan, D Kharzeev, M Kim, Y Kim, P King, E Kinney, S Klein, H Ko, V Koch, M Kohl, Y Kovchegov, G Krintiras, V Kubarovsky, S Kuhn, K Kumar, T Kutz, J Lajoie, J Lauret, I Lavrukhin, D Lawrence, J Lee, K Lee, S Lee, Y Lee, S Li, W Li, X Li, J Liao, H Lin, M Lisa, K Liu, M Liu, T Liu, S Liuti, N Liyanage, W Llope, C Loizides, R Longo, W Lorenzon, X Luo, R Ma, B McKinnon, D Meekins, Y Mehtar-Tani, W Melnitchouk, A Metz, C Meyer, Z Meziani, R Michaels, R Milner, H Mkrtchyan, P Mohanmurthy, B Mohanty, V Mokeev, I Mooney, C Morningstar, D Morrison, B Muller, S Mukherjee, J Mulligan, C Munoz Camacho, J Murillo Quijada, M Murray, S Nadeeshani, P Nadel-Turonski, J Nam, C Nattrass, G Nijs, J Norohna, J Noronha-Hostler, N Novitzky, M Nycz, F Olness, J Osborn, R Pak, B Pandey, M Paolone, Z Papandreou, J Paquet, S Park, K Paschke, B Pasquini, E Pasyuk, T Patel, A Patton, C Paudel, C Peng, J Peng, H Pereira Da Costa, D Perepelitsa, M Peters, P Petreczky, R Pisarski, D Pitonyak, M Ploskon, M Posik, J Poudel, R Pradhan, A Prokudin, C Pruneau, J Putschke, J Pybus, J Qiu, K Rajagopal, C Ratti, K Read, R Reed, D Richards, C Riedl, F Ringer, T Rinn, J Rittenhouse West, J Roche, A Rodas, G Roland, F Romero-Lopez, P Rossi, T Rostomyan, L Ruan, O Ruimi, N Saha, N Sahoo, T Sakaguchi, F Salazar, C Salgado, G Salme, S Salur, S Santiesteban, M Sargsian, M Sarsour, N Sato, T Satogata, S Sawada, T Schafer, B Scheihing-Hitschfeld, B Schenke, S Schindler, A Schmidt, R Seidl, M Sabestari, P Shanahan, C Shen, T Sheng, M Shepherd, A M Sickles, M Sievert, K Smith, Y Song, A Sorensen, P Souder, N Spareveris, S Srednyak, A Stahl Leiton, A Stasto, P Steinberg, S Stepanyan, M Stephanov, J Stevens, D Stewart, I Stewart, M Stojanovic, I Strakovsky, S Strauch, M Strickland, D Sunar Cerci, M Suresh, B Surrow, S Syritsyn, A Szczepaniak, A Tadepalli, A H Tang, J Tapia Takaki, T Tarnowsky, A Tawfik, M Taylor, C Tennant, A Thiel, D Thomas, Y Tian, A Timmins, P Tribedy, Z Tu, S Tuo, T Ullrich, E Umaka, N Ghimire, J Vary, J Velkovska, R Venugopalan, A Vijayakumar, I Vitev, W Vogelsang, R Vogt, A Vossen, E Voutier, V Vovchenko, A Walker-Loud, F Wang, J Wang, X Wang, L Weinstein, T Wenaus, S Weyhmiller, S Wissink, B Wojtsekhowski, C Wong, M Wood, Y Wunderlich, B Wyslouch, B Xiao, W Xie, W Xiong, N Xu, Q Xu, Z Xu, D Yaari, X Yao, Z Ye, C Yero, F Yuan, W Zajc, C Zhang, J Zhang, F Zhao, Y Zhao, Z Zhao, X Zheng, and J Zhou

Published
2023

21. Functional Rehabilitation: An Integrated Treatment Model for Patients With Complex Physical and Psychiatric Conditions

Author

William H. Orme, J. Christopher Fowler, Major R. Bradshaw, Marianne Carlson, Julia Hadden, Jelani Daniel, James N. Flack, Diana Freeland, John Head, Kate Marder, Benjamin L. Weinstein, and Alok Madan

Subjects
Treatment Outcome, Mental Disorders, Humans, Comorbidity, Referral and Consultation
Abstract

The health care delivery system in the United States, structured to provide single-disease care, presents unique challenges for patients with complex physical and psychiatric comorbidities. Patients in these populations are often referred to multiple specialty clinics, encounter little continuity of care or collaboration among their providers, incur high health care costs, and experience poor treatment outcomes. Given these barriers, questions remain about the extent to which siloed and fragmented care, as opposed to the complex nature of the illnesses themselves, contribute to poor outcomes. If given the opportunity to receive well-integrated, consistent, and personalized care, can patients with historically difficult-to-treat comorbid medical and mental illnesses make progress? This article describes an innovative model of care called functional rehabilitation that is designed to address existing barriers in treatment. The functional rehabilitation program seeks to disrupt the escalating effects of interacting comorbidities by offering highly collaborative treatment from a small team of clinicians, personalized interventions using a shared decision-making framework, multipronged treatment options, colocation in a large hospital system, and significant 1:1 time with patients. The article includes a case example with longitudinal outcome data that illustrates how progress can be made with appropriate programmatic supports. Future research should examine the cost-effectiveness of this model of care.

Published
2022

22. ECCE sensitivity studies for single hadron transverse single spin asymmetry measurements

Author

R. Seidl, A. Vladimirov, D. Pitonyak, A. Prokudin, J.K. Adkins, Y. Akiba, A. Albataineh, M. Amaryan, I.C. Arsene, C. Ayerbe Gayoso, J. Bae, X. Bai, M.D. Baker, M. Bashkanov, R. Bellwied, F. Benmokhtar, V. Berdnikov, J.C. Bernauer, F. Bock, W. Boeglin, M. Borysova, E. Brash, P. Brindza, W.J. Briscoe, M. Brooks, S. Bueltmann, M.H.S. Bukhari, A. Bylinkin, R. Capobianco, W.-C. Chang, Y. Cheon, K. Chen, K.-F. Chen, K.-Y. Cheng, M. Chiu, T. Chujo, Z. Citron, E. Cline, E. Cohen, T. Cormier, Y. Corrales Morales, C. Cotton, J. Crafts, C. Crawford, S. Creekmore, C. Cuevas, J. Cunningham, G. David, C.T. Dean, M. Demarteau, S. Diehl, N. Doshita, R. Dupré, J.M. Durham, R. Dzhygadlo, R. Ehlers, L. El Fassi, A. Emmert, R. Ent, C. Fanelli, R. Fatemi, S. Fegan, M. Finger, J. Frantz, M. Friedman, I. Friscic, D. Gangadharan, S. Gardner, K. Gates, F. Geurts, R. Gilman, D. Glazier, E. Glimos, Y. Goto, N. Grau, S.V. Greene, A.Q. Guo, L. Guo, S.K. Ha, J. Haggerty, T. Hayward, X. He, O. Hen, D.W. Higinbotham, M. Hoballah, T. Horn, A. Hoghmrtsyan, P.-h.J. Hsu, J. Huang, G. Huber, A. Hutson, K.Y. Hwang, C.E. Hyde, M. Inaba, T. Iwata, H.S. Jo, K. Joo, N. Kalantarians, G. Kalicy, K. Kawade, S.J.D. Kay, A. Kim, B. Kim, C. Kim, M. Kim, Y. Kim, E. Kistenev, V. Klimenko, S.H. Ko, I. Korover, W. Korsch, G. Krintiras, S. Kuhn, C.-M. Kuo, T. Kutz, J. Lajoie, D. Lawrence, S. Lebedev, H. Lee, J.S.H. Lee, S.W. Lee, Y.-J. Lee, W. Li, W.B. Li, X. Li, Y.T. Liang, S. Lim, C.-H. Lin, D.X. Lin, K. Liu, M.X. Liu, K. Livingston, N. Liyanage, W.J. Llope, C. Loizides, E. Long, R.-S. Lu, Z. Lu, W. Lynch, S. Mantry, D. Marchand, M. Marcisovsky, C. Markert, P. Markowitz, H. Marukyan, P. McGaughey, M. Mihovilovic, R.G. Milner, A. Milov, Y. Miyachi, A. Mkrtchyan, P. Monaghan, R. Montgomery, D. Morrison, A. Movsisyan, H. Mkrtchyan, C. Munoz Camacho, M. Murray, K. Nagai, J. Nagle, I. Nakagawa, C. Nattrass, D. Nguyen, S. Niccolai, R. Nouicer, G. Nukazuka, M. Nycz, V.A. Okorokov, S. Orešić, J.D. Osborn, C. O’Shaughnessy, S. Paganis, Z. Papandreou, S.F. Pate, M. Patel, C. Paus, G. Penman, M.G. Perdekamp, D.V. Perepelitsa, H. Periera da Costa, K. Peters, W. Phelps, E. Piasetzky, C. Pinkenburg, I. Prochazka, T. Protzman, M.L. Purschke, J. Putschke, J.R. Pybus, R. Rajput-Ghoshal, J. Rasson, B. Raue, K.F. Read, K. Røed, R. Reed, J. Reinhold, E.L. Renner, J. Richards, C. Riedl, T. Rinn, J. Roche, G.M. Roland, G. Ron, M. Rosati, C. Royon, J. Ryu, S. Salur, N. Santiesteban, R. Santos, M. Sarsour, J. Schambach, A. Schmidt, N. Schmidt, C. Schwarz, J. Schwiening, A. Sickles, P. Simmerling, S. Sirca, D. Sharma, Z. Shi, T.-A. Shibata, C.-W. Shih, S. Shimizu, U. Shrestha, K. Slifer, K. Smith, D. Sokhan, R. Soltz, W. Sondheim, J. Song, I.I. Strakovsky, P. Steinberg, P. Stepanov, J. Stevens, J. Strube, P. Sun, X. Sun, K. Suresh, V. Tadevosyan, W.-C. Tang, S. Tapia Araya, S. Tarafdar, L. Teodorescu, D. Thomas, A. Timmins, L. Tomasek, N. Trotta, R. Trotta, T.S. Tveter, E. Umaka, A. Usman, H.W. van Hecke, C. Van Hulse, J. Velkovska, E. Voutier, P.K. Wang, Q. Wang, Y. Wang, D.P. Watts, N. Wickramaarachchi, L. Weinstein, M. Williams, C.-P. Wong, L. Wood, M.H. Wood, C. Woody, B. Wyslouch, Z. Xiao, Y. Yamazaki, Y. Yang, Z. Ye, H.D. Yoo, M. Yurov, N. Zachariou, W.A. Zajc, W. Zha, J.-L. Zhang, J.-X. Zhang, Y. Zhang, Y.-X. Zhao, X. Zheng, P. Zhuang, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
transverse spin dependent distribution and fragmentation functions, Nuclear and High Energy Physics, FOS: Physical sciences, lepton: scattering, transverse momentum dependence, hadron: transverse momentum, fragmentation function, x-dependence, High Energy Physics - Experiment, Sivers function, semi-inclusive DIS, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], parton, Collins, Instrumentation, transversity, spin: transverse, flavor, deep inelastic scattering: semi-inclusive reaction, positron p: deep inelastic scattering, nucleon: spin: transverse, sensitivity, Transverse spin dependent distribution and fragmentation functions, error: statistical, kinematics, ECCE detector feasibility studies, charge: tensor, numerical calculations: Monte Carlo, Semi-inclusive DIS, spin: asymmetry
Abstract

We performed feasibility studies for various single transverse spin measurements that are related to the Sivers effect, transversity and the tensor charge, and the Collins fragmentation function. The processes studied include semi-inclusive deep inelastic scattering (SIDIS) where single hadrons (pions and kaons) were detected in addition to the scattered DIS lepton. The data were obtained in {\sc pythia}6 and {\sc geant}4 simulated e+p collisions at 18 GeV on 275 GeV, 18 on 100, 10 on 100, and 5 on 41 that use the ECCE detector configuration. Typical DIS kinematics were selected, most notably $Q^2 > 1 $ GeV$^2$, and cover the $x$ range from $10^{-4}$ to $1$. The single spin asymmetries were extracted as a function of $x$ and $Q^2$, as well as the semi-inclusive variables $z$, and $P_T$. They are obtained in azimuthal moments in combinations of the azimuthal angles of the hadron transverse momentum and transverse spin of the nucleon relative to the lepton scattering plane. The initially unpolarized MonteCarlo was re-weighted in the true kinematic variables, hadron types and parton flavors based on global fits of fixed target SIDIS experiments and $e^+e^-$ annihilation data. The expected statistical precision of such measurements is extrapolated to 10 fb$^{-1}$ and potential systematic uncertainties are approximated given the deviations between true and reconstructed yields. The impact on the knowledge of the Sivers functions, transversity and tensor charges, and the Collins function has then been evaluated in the same phenomenological extractions as in the Yellow Report. The impact is found to be comparable to that obtained with the parameterized Yellow Report detector and shows that the ECCE detector configuration can fulfill the physics goals on these quantities., 22 pages, 22 figures, to be submitted to joint ECCE proposal NIM-A volume

Published
2023

23. Leading an Organization in the 21st Century: The Importance of Environmental Sustainability, Social Responsibility, and Good Governance

Author

Kristy, Weber, M Bradford, Henley, James, Balaschak, and Stuart L, Weinstein

Subjects
Social Responsibility, Humans, United States
Abstract

The concept of environmental sustainability, social responsibility, and good governance (ESG) is now well established in the corporate world and in for-profit organizations. However, it is not a concept that has reached medical and surgical association boardrooms in a meaningful way. It is important to define the concept of physician and corporate author expertise and objectives of ESG, provide a rationale for using ESG within orthopaedic organizations, and identify specific areas (primarily the "S" and the "G") where the American Academy of Orthopaedic Surgeons and other groups can align with this strategy.

Published
2022

24. Developmental Dysplasia of the Hip From Birth to Adolescence: Clear Indications and New Controversies

Author

Stuart L, Weinstein, Pablo G, Casteñada, Wudbhav N, Sankar, Hilary T, Campbell, and Raghav, Badrinath

Subjects
Adolescent, Joint Dislocations, Humans, Developmental Dysplasia of the Hip, Hip Joint, Hip Dislocation, Congenital
Abstract

It is important to be knowledgeable about the latest information on the diagnosis and the evidence-based management of developmental hip dysplasia and dislocation from birth through adolescence. The focus should be on the effect of the problem; normal growth and development of the hip joint; and the pathoanatomy, natural history, and long-term outcomes of developmental dysplasia of the hip, hip subluxation, and dysplasia. Many controversies exist in the management of this complex spectrum of disorders.

Published
2022

26. Ibrexafungerp Versus Placebo for Vulvovaginal Candidiasis Treatment: A Phase 3, Randomized, Controlled Superiority Trial (VANISH 303)

Author

Samuel N. Lederman, Nkechi Azie, Itzel A Harriott, Paul Nyirjesy, Alfred H. Moffett, Steven A Sussman, David L Weinstein, David Angulo, Mahmoud A. Ghannoum, Mark Jacobs, Janet K Gersten, B Todd Chappell, Jack D. Sobel, Katyna Borroto-Esoda, Jane R. Schwebke, and Ryan Sobel

Subjects
Azoles, Microbiology (medical), medicine.medical_specialty, Oral treatment, Antifungal Agents, Placebo, Superiority Trial, Internal medicine, Clinical endpoint, Humans, Medicine, Glycosides, Candida albicans, Adverse effect, Candidiasis, Vulvovaginal, chemistry.chemical_classification, biology, business.industry, biology.organism_classification, Triterpenes, Infectious Diseases, chemistry, Vulvovaginal Candidiasis, Azole, Female, business
Abstract

Background Current treatment of vulvovaginal candidiasis (VVC) is largely limited to azole therapy. Ibrexafungerp is a first-in-class triterpenoid antifungal with broad-spectrum anti-Candida fungicidal activity. The objective of this study was to evaluate the efficacy and safety of ibrexafungerp compared with placebo in patients with acute VVC. Methods Patients were randomly assigned 2:1 to receive ibrexafungerp (300 mg twice for 1 day) or placebo. The primary endpoint was the percentage of patients with a clinical cure (complete resolution of vulvovaginal signs and symptoms [VSS] = 0) at test-of-cure (day 11 ± 3). Secondary endpoints included the percentage of patients with mycological eradication, overall success (clinical cure and mycological eradication), clinical improvement (VSS ≤ 1) at test-of-cure, and symptom resolution at follow-up (day 25 ± 4). Results Patients receiving ibrexafungerp had significantly higher rates of clinical cure (50.5% [95/188] vs 28.6% [28/98]; P = .001), mycological eradication (49.5% [93/188] vs 19.4% [19/98]; P < .001), and overall success (36.0% [64/178] vs 12.6% [12/95]; P < .001) compared with placebo. Symptom resolution was sustained and further increased with ibrexafungerp compared with placebo (59.6% [112/188] vs 44.9% [44/98]; P = .009) at follow-up. Post hoc analysis showed similar rates of clinical cure and clinical improvement at test-of-cure for Black patients (54.8% [40/73] and 63.4% [47/73], respectively) and patients with a body mass index >35 (54.5% [24/44] and 68.2% [30/44], respectively) compared with overall rates. Ibrexafungerp was well tolerated. Adverse events were primarily gastrointestinal and mild in severity. Conclusions Ibrexafungerp provides a promising safe and efficacious oral treatment that mechanistically differs from current azole treatment options for acute VVC.

Published
2021

28. Differential co-expression networks of the gut microbiota are associated with depression and anxiety treatment resistance among psychiatric inpatients

Author

Dominique S. Thompson, Chenlian Fu, Tanmay Gandhi, J. Christopher Fowler, B. Christopher Frueh, Benjamin L. Weinstein, Joseph Petrosino, Julia K. Hadden, Marianne Carlson, Cristian Coarfa, and Alok Madan

Subjects
Pharmacology, Inpatients, Depression, Humans, Anxiety, Biological Psychiatry, Article, Biomarkers, Gastrointestinal Microbiome
Abstract

BACKGROUND: Comorbid anxiety and depression are common and are associated with greater disease burden than either alone. Our recent efforts have identified an association between gut microbiota dysfunction and severity of anxiety and depression. In this follow-up, we applied Differential Co-Expression Analysis (DiffCoEx) to identify potential gut microbiota biomarker(s) candidates of treatment resistance among psychiatric inpatients. METHODS: In a sample of convenience, 100 psychiatric inpatients provided clinical data at admission and discharge; fecal samples were collected early during the hospitalization. Whole genome shotgun sequencing methods were used to process samples. DiffCoEx was used to identify clusters of microbial features significantly different based on treatment resistance status. Once overlapping features were identified, a knowledge-mining tool was used to review the literature using a list of microbial species/pathways and a select number of medical subject headlines (MeSH) terms relevant for depression, anxiety, and brain-gut-axis dysregulation. Network analysis used overlapping features to identify microbial interactions that could impact treatment resistance. RESULTS: DiffCoEx analyzed 10,403 bacterial features: 43/44 microbial features associated with depression treatment resistance overlapped with 43/114 microbial features associated with anxiety treatment resistance. Network analysis resulted in 8 biological interactions between 16 bacterial species. Clostridium perfringens evidenced the highest connection strength (0.95). Erysipelotrichaceae bacterium 6_1_45 has been most widely examined, is associated with inflammation and dysbiosis, but has not been associated with depression or anxiety. CONCLUSION: DiffCoEx potentially identified gut bacteria biomarker candidates of depression and anxiety treatment-resistance. Future efforts in psychiatric microbiology should examine the mechanistic relationship of identified pro-inflammatory species, potentially contributing to a biomarker-based algorithm for treatment resistance.

Published
2022

30. Search for e→τ charged lepton flavor violation at the EIC with the ECCE detector

Author

J.-L. Zhang, S. Mantry, J.K. Adkins, Y. Akiba, A. Albataineh, M. Amaryan, I.C. Arsene, C. Ayerbe Gayoso, J. Bae, X. Bai, M.D. Baker, M. Bashkanov, R. Bellwied, F. Benmokhtar, V. Berdnikov, J.C. Bernauer, F. Bock, W. Boeglin, M. Borysova, E. Brash, P. Brindza, W.J. Briscoe, M. Brooks, S. Bueltmann, M.H.S. Bukhari, A. Bylinkin, R. Capobianco, W.-C. Chang, Y. Cheon, K. Chen, K.-F. Chen, K.-Y. Cheng, M. Chiu, T. Chujo, Z. Citron, E. Cline, E. Cohen, T. Cormier, Y. Corrales Morales, C. Cotton, J. Crafts, C. Crawford, S. Creekmore, C. Cuevas, J. Cunningham, G. David, C.T. Dean, M. Demarteau, S. Diehl, N. Doshita, R. Dupré, J.M. Durham, R. Dzhygadlo, R. Ehlers, L. El Fassi, A. Emmert, R. Ent, C. Fanelli, R. Fatemi, S. Fegan, M. Finger, J. Frantz, M. Friedman, I. Friscic, D. Gangadharan, S. Gardner, K. Gates, F. Geurts, R. Gilman, D. Glazier, E. Glimos, Y. Goto, N. Grau, S.V. Greene, A.Q. Guo, L. Guo, S.K. Ha, J. Haggerty, T. Hayward, X. He, O. Hen, D.W. Higinbotham, M. Hoballah, T. Horn, A. Hoghmrtsyan, P.-h.J. Hsu, J. Huang, G. Huber, A. Hutson, K.Y. Hwang, C.E. Hyde, M. Inaba, T. Iwata, H.S. Jo, K. Joo, N. Kalantarians, G. Kalicy, K. Kawade, S.J.D. Kay, A. Kim, B. Kim, C. Kim, M. Kim, Y. Kim, E. Kistenev, V. Klimenko, S.H. Ko, I. Korover, W. Korsch, G. Krintiras, S. Kuhn, C.-M. Kuo, T. Kutz, J. Lajoie, D. Lawrence, S. Lebedev, H. Lee, J.S.H. Lee, S.W. Lee, Y.-J. Lee, W. Li, W.B. Li, X. Li, Y.T. Liang, S. Lim, C.-H. Lin, D.X. Lin, K. Liu, M.X. Liu, K. Livingston, N. Liyanage, W.J. Llope, C. Loizides, E. Long, R.-S. Lu, Z. Lu, W. Lynch, D. Marchand, M. Marcisovsky, C. Markert, P. Markowitz, H. Marukyan, P. McGaughey, M. Mihovilovic, R.G. Milner, A. Milov, Y. Miyachi, A. Mkrtchyan, H. Mkrtchyan, P. Monaghan, R. Montgomery, D. Morrison, A. Movsisyan, C. Munoz Camacho, M. Murray, K. Nagai, J. Nagle, I. Nakagawa, C. Nattrass, D. Nguyen, S. Niccolai, R. Nouicer, G. Nukazuka, M. Nycz, V.A. Okorokov, S. Orešić, J.D. Osborn, C. O’Shaughnessy, S. Paganis, Z. Papandreou, S.F. Pate, M. Patel, C. Paus, G. Penman, M.G. Perdekamp, D.V. Perepelitsa, H. Periera da Costa, K. Peters, W. Phelps, E. Piasetzky, C. Pinkenburg, I. Prochazka, T. Protzman, M.L. Purschke, J. Putschke, J.R. Pybus, R. Rajput-Ghoshal, J. Rasson, B. Raue, K.F. Read, K. Røed, R. Reed, J. Reinhold, E.L. Renner, J. Richards, C. Riedl, T. Rinn, J. Roche, G.M. Roland, G. Ron, M. Rosati, C. Royon, J. Ryu, S. Salur, N. Santiesteban, R. Santos, M. Sarsour, J. Schambach, A. Schmidt, N. Schmidt, C. Schwarz, J. Schwiening, R. Seidl, A. Sickles, P. Simmerling, S. Sirca, D. Sharma, Z. Shi, T.-A. Shibata, C.-W. Shih, S. Shimizu, U. Shrestha, K. Slifer, K. Smith, D. Sokhan, R. Soltz, W. Sondheim, J. Song, I.I. Strakovsky, P. Steinberg, P. Stepanov, J. Stevens, J. Strube, P. Sun, X. Sun, K. Suresh, V. Tadevosyan, W.-C. Tang, S. Tapia Araya, S. Tarafdar, L. Teodorescu, D. Thomas, A. Timmins, L. Tomasek, N. Trotta, R. Trotta, T.S. Tveter, E. Umaka, A. Usman, H.W. van Hecke, C. Van Hulse, J. Velkovska, E. Voutier, P.K. Wang, Q. Wang, Y. Wang, D.P. Watts, N. Wickramaarachchi, L. Weinstein, M. Williams, C.-P. Wong, L. Wood, M.H. Wood, C. Woody, B. Wyslouch, Z. Xiao, Y. Yamazaki, Y. Yang, Z. Ye, H.D. Yoo, M. Yurov, N. Zachariou, W.A. Zajc, W. Zha, J.-X. Zhang, Y. Zhang, Y.-X. Zhao, X. Zheng, and P. Zhuang

Subjects
Nuclear and High Energy Physics, Instrumentation
Published
2023

31. Gender differences in quality of life and preferences for location‐specific amenities across cities

Author

Amanda L. Weinstein and Curtis Lockwood Reynolds

Subjects
Consumption (economics), Quality of life, Control (management), Demographic economics, Business, Environmental Science (miscellaneous), Development, Gender role, Public good, Set (psychology), Natural resource, Consumer behaviour
Abstract

The quality of life literature revealed the role that natural resources and local consumption amenities play in household preferences for cities and their growing importance in determining the success of cities. As women's control over household resources has increased, a growing body of consumer behavior literature has been documenting gender differences in preferences for consumer goods. Yet, the quality of life literature does not seem to make any distinction along gender lines in determining preferences for local consumption amenities. We estimate the quality of life across US cities separately for unmarried men and women, and using a rich set of location‐specific amenities, examine which amenities cause preferences to differ between men and women. Our results suggest that men and women's valuations of cities are correlated, suggesting commonality in preferences for many location‐based amenities, most notably natural resources, but there are also important deviations in valuations especially for local public goods and gender role attitudes.

Published
2021

33. Tales of diversity: Genomic and morphological characteristics of forty-six Arthrobacter phages.

Author

Karen K Klyczek, J Alfred Bonilla, Deborah Jacobs-Sera, Tamarah L Adair, Patricia Afram, Katherine G Allen, Megan L Archambault, Rahat M Aziz, Filippa G Bagnasco, Sarah L Ball, Natalie A Barrett, Robert C Benjamin, Christopher J Blasi, Katherine Borst, Mary A Braun, Haley Broomell, Conner B Brown, Zachary S Brynell, Ashley B Bue, Sydney O Burke, William Casazza, Julia A Cautela, Kevin Chen, Nitish S Chimalakonda, Dylan Chudoff, Jade A Connor, Trevor S Cross, Kyra N Curtis, Jessica A Dahlke, Bethany M Deaton, Sarah J Degroote, Danielle M DeNigris, Katherine C DeRuff, Milan Dolan, David Dunbar, Marisa S Egan, Daniel R Evans, Abby K Fahnestock, Amal Farooq, Garrett Finn, Christopher R Fratus, Bobby L Gaffney, Rebecca A Garlena, Kelly E Garrigan, Bryan C Gibbon, Michael A Goedde, Carlos A Guerrero Bustamante, Melinda Harrison, Megan C Hartwell, Emily L Heckman, Jennifer Huang, Lee E Hughes, Kathryn M Hyduchak, Aswathi E Jacob, Machika Kaku, Allen W Karstens, Margaret A Kenna, Susheel Khetarpal, Rodney A King, Amanda L Kobokovich, Hannah Kolev, Sai A Konde, Elizabeth Kriese, Morgan E Lamey, Carter N Lantz, Jonathan S Lapin, Temiloluwa O Lawson, In Young Lee, Scott M Lee, Julia Y Lee-Soety, Emily M Lehmann, Shawn C London, A Javier Lopez, Kelly C Lynch, Catherine M Mageeney, Tetyana Martynyuk, Kevin J Mathew, Travis N Mavrich, Christopher M McDaniel, Hannah McDonald, C Joel McManus, Jessica E Medrano, Francis E Mele, Jennifer E Menninger, Sierra N Miller, Josephine E Minick, Courtney T Nabua, Caroline K Napoli, Martha Nkangabwa, Elizabeth A Oates, Cassandra T Ott, Sarah K Pellerino, William J Pinamont, Ross T Pirnie, Marie C Pizzorno, Emilee J Plautz, Welkin H Pope, Katelyn M Pruett, Gabbi Rickstrew, Patrick A Rimple, Claire A Rinehart, Kayla M Robinson, Victoria A Rose, Daniel A Russell, Amelia M Schick, Julia Schlossman, Victoria M Schneider, Chloe A Sells, Jeremy W Sieker, Morgan P Silva, Marissa M Silvi, Stephanie E Simon, Amanda K Staples, Isabelle L Steed, Emily L Stowe, Noah A Stueven, Porter T Swartz, Emma A Sweet, Abigail T Sweetman, Corrina Tender, Katrina Terry, Chrystal Thomas, Daniel S Thomas, Allison R Thompson, Lorianna Vanderveen, Rohan Varma, Hannah L Vaught, Quynh D Vo, Zachary T Vonberg, Vassie C Ware, Yasmene M Warrad, Kaitlyn E Wathen, Jonathan L Weinstein, Jacqueline F Wyper, Jakob R Yankauskas, Christine Zhang, and Graham F Hatfull

Subjects
Medicine, Science
Abstract

The vast bacteriophage population harbors an immense reservoir of genetic information. Almost 2000 phage genomes have been sequenced from phages infecting hosts in the phylum Actinobacteria, and analysis of these genomes reveals substantial diversity, pervasive mosaicism, and novel mechanisms for phage replication and lysogeny. Here, we describe the isolation and genomic characterization of 46 phages from environmental samples at various geographic locations in the U.S. infecting a single Arthrobacter sp. strain. These phages include representatives of all three virion morphologies, and Jasmine is the first sequenced podovirus of an actinobacterial host. The phages also span considerable sequence diversity, and can be grouped into 10 clusters according to their nucleotide diversity, and two singletons each with no close relatives. However, the clusters/singletons appear to be genomically well separated from each other, and relatively few genes are shared between clusters. Genome size varies from among the smallest of siphoviral phages (15,319 bp) to over 70 kbp, and G+C contents range from 45-68%, compared to 63.4% for the host genome. Although temperate phages are common among other actinobacterial hosts, these Arthrobacter phages are primarily lytic, and only the singleton Galaxy is likely temperate.

Published
2017
Full Text
View/download PDF

34. Radioembolization for Cholangiocarcinoma

Author

Salomao Faintuch, Muneeb Ahmed, Ammar Sarwar, Komal Manzoor, Jeffrey L. Weinstein, and A. Ali

Subjects
medicine.medical_specialty, business.industry, Systemic chemotherapy, Incidence (epidemiology), Gastroenterology, Transarterial Radioembolization, digestive system, digestive system diseases, Hepatic malignancy, 030218 nuclear medicine & medical imaging, Review article, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Localized disease, Medicine, Radiology, Nuclear Medicine and imaging, Surgery, In patient, Radiology, business, neoplasms, Intrahepatic Cholangiocarcinoma
Abstract

Cholangiocarcinoma is the second most common primary hepatic malignancy which accounts for 13% of total cancer mortality worldwide. Surgical resection is the only curative treatment for localized disease; however, the majority of patients present when the tumor is unresectable. The incidence of the intrahepatic subtype of cholangiocarcinoma is increasing worldwide. Current standard of care in patients with unresectable intrahepatic cholangiocarcinoma is systemic chemotherapy; however, yttrium-90 transarterial radioembolization (Y90-TARE) is under investigation for the treatment of intrahepatic cholangiocarcinoma with promising trials and published clinical experience. This review critically evaluates the role of Y90-TARE in the management of intrahepatic cholangiocarcinoma.

Published
2021

36. Exclusive J/ψ detection and physics with ECCE

Author

X. Li, J.K. Adkins, Y. Akiba, A. Albataineh, M. Amaryan, I.C. Arsene, C. Ayerbe Gayoso, J. Bae, X. Bai, M.D. Baker, M. Bashkanov, R. Bellwied, F. Benmokhtar, V. Berdnikov, J.C. Bernauer, F. Bock, W. Boeglin, M. Borysova, E. Brash, P. Brindza, W.J. Briscoe, M. Brooks, S. Bueltmann, M.H.S. Bukhari, A. Bylinkin, R. Capobianco, W.-C. Chang, Y. Cheon, K. Chen, K.-F. Chen, K.-Y. Cheng, M. Chiu, T. Chujo, Z. Citron, E. Cline, E. Cohen, T. Cormier, Y. Corrales Morales, C. Cotton, J. Crafts, C. Crawford, S. Creekmore, C. Cuevas, J. Cunningham, G. David, C.T. Dean, M. Demarteau, S. Diehl, N. Doshita, R. Dupré, J.M. Durham, R. Dzhygadlo, R. Ehlers, L. El Fassi, A. Emmert, R. Ent, C. Fanelli, R. Fatemi, S. Fegan, M. Finger, J. Frantz, M. Friedman, I. Friscic, D. Gangadharan, S. Gardner, K. Gates, F. Geurts, R. Gilman, D. Glazier, E. Glimos, Y. Goto, N. Grau, S.V. Greene, A.Q. Guo, L. Guo, S.K. Ha, J. Haggerty, T. Hayward, X. He, O. Hen, D.W. Higinbotham, M. Hoballah, T. Horn, A. Hoghmrtsyan, P.-h.J. Hsu, J. Huang, G. Huber, A. Hutson, K.Y. Hwang, C.E. Hyde, M. Inaba, T. Iwata, H.S. Jo, K. Joo, N. Kalantarians, G. Kalicy, K. Kawade, S.J.D. Kay, A. Kim, B. Kim, C. Kim, M. Kim, Y. Kim, E. Kistenev, V. Klimenko, S.H. Ko, I. Korover, W. Korsch, G. Krintiras, S. Kuhn, C.-M. Kuo, T. Kutz, J. Lajoie, D. Lawrence, S. Lebedev, H. Lee, J.S.H. Lee, S.W. Lee, Y.-J. Lee, W. Li, W.B. Li, Y.T. Liang, S. Lim, C.-H. Lin, D.X. Lin, K. Liu, M.X. Liu, K. Livingston, N. Liyanage, W.J. Llope, C. Loizides, E. Long, R.-S. Lu, Z. Lu, W. Lynch, S. Mantry, D. Marchand, M. Marcisovsky, C. Markert, P. Markowitz, H. Marukyan, P. McGaughey, M. Mihovilovic, R.G. Milner, A. Milov, Y. Miyachi, A. Mkrtchyan, P. Monaghan, R. Montgomery, D. Morrison, A. Movsisyan, H. Mkrtchyan, C. Munoz Camacho, M. Murray, K. Nagai, J. Nagle, I. Nakagawa, C. Nattrass, D. Nguyen, S. Niccolai, R. Nouicer, G. Nukazuka, M. Nycz, V.A. Okorokov, S. Orešić, J.D. Osborn, C. O’Shaughnessy, S. Paganis, Z. Papandreou, S.F. Pate, M. Patel, C. Paus, G. Penman, M.G. Perdekamp, D.V. Perepelitsa, H. Periera da Costa, K. Peters, W. Phelps, E. Piasetzky, C. Pinkenburg, I. Prochazka, T. Protzman, M.L. Purschke, J. Putschke, J.R. Pybus, R. Rajput-Ghoshal, J. Rasson, B. Raue, K.F. Read, K. Røed, R. Reed, J. Reinhold, E.L. Renner, J. Richards, C. Riedl, T. Rinn, J. Roche, G.M. Roland, G. Ron, M. Rosati, C. Royon, J. Ryu, S. Salur, N. Santiesteban, R. Santos, M. Sarsour, J. Schambach, A. Schmidt, N. Schmidt, C. Schwarz, J. Schwiening, R. Seidl, A. Sickles, P. Simmerling, S. Sirca, D. Sharma, Z. Shi, T.-A. Shibata, C.-W. Shih, S. Shimizu, U. Shrestha, K. Slifer, K. Smith, D. Sokhan, R. Soltz, W. Sondheim, J. Song, I.I. Strakovsky, P. Steinberg, P. Stepanov, J. Stevens, J. Strube, P. Sun, X. Sun, K. Suresh, V. Tadevosyan, W.-C. Tang, S. Tapia Araya, S. Tarafdar, L. Teodorescu, D. Thomas, A. Timmins, L. Tomasek, N. Trotta, R. Trotta, T.S. Tveter, E. Umaka, A. Usman, H.W. van Hecke, C. Van Hulse, J. Velkovska, E. Voutier, P.K. Wang, Q. Wang, Y. Wang, D.P. Watts, N. Wickramaarachchi, L. Weinstein, M. Williams, C.-P. Wong, L. Wood, M.H. Wood, C. Woody, B. Wyslouch, Z. Xiao, Y. Yamazaki, Y. Yang, Z. Ye, H.D. Yoo, M. Yurov, N. Zachariou, W.A. Zajc, W. Zha, J.-L. Zhang, J.-X. Zhang, Y. Zhang, Y.-X. Zhao, X. Zheng, P. Zhuang, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Quarkonia, design, electron nucleon, Near threshold, EIC, pomeron, threshold, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], colliding beams, structure, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment, Instrumentation, detector, exchange, nucleus, Electron Ion Collider, nucleon, gluon, statistics, Exclusive, mass, production, ECCE, quarkonium, performance, photoproduction
Abstract

Exclusive heavy quarkonium photoproduction is one of the most popular processes in EIC, which has a large cross section and a simple final state. Due to the gluonic nature of the exchange Pomeron, this process can be related to the gluon distributions in the nucleus. The momentum transfer dependence of this process is sensitive to the interaction sites, which provides a powerful tool to probe the spatial distribution of gluons in the nucleus. Recently the problem of the origin of hadron mass has received lots of attention in determining the anomaly contribution $M_{a}$. The trace anomaly is sensitive to the gluon condensate, and exclusive production of quarkonia such as J/$\psi$ and $\Upsilon$ can serve as a sensitive probe to constrain it. In this paper, we present the performance of the ECCE detector for exclusive J/$\psi$ detection and the capability of this process to investigate the above physics opportunities with ECCE., Comment: 11 pages, 14 figures, 1 table

Published
2023

37. Analysis of Kinematic Differences in Hand Motion between Novice and Experienced Operators in IR: A Pilot Study

Author

Matthew R. Palmer, Salomao Faintuch, Seth A. Berkowitz, Robina Matyal, Muneeb Ahmed, Feroze Mahmood, Jeffrey L. Weinstein, Julie C. Bulman, Ammar Sarwar, Fady El-Gabalawy, and Sarah E. Schroeppel DeBacker

Subjects
medicine.medical_specialty, Time Factors, Radiography, Pilot Projects, Punctures, Kinematics, Radiography, Interventional, 030218 nuclear medicine & medical imaging, Task (project management), 03 medical and health sciences, 0302 clinical medicine, Operator (computer programming), Physical medicine and rehabilitation, medicine.artery, Catheterization, Peripheral, Radiologists, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Radial artery, Motor skill, medicine.diagnostic_test, business.industry, Interventional radiology, Motion detection, Hand, Biomechanical Phenomena, Motor Skills, 030220 oncology & carcinogenesis, Radial Artery, Feasibility Studies, Clinical Competence, Cardiology and Cardiovascular Medicine, business, Electromagnetic Phenomena
Abstract

To prospectively validate electromagnetic hand motion tracking in interventional radiology to detect differences in operator experience using simulation.Sheath task: Six attending interventional radiologists (experts) and 6 radiology trainees (trainees) placed a wire through a sheath and performed a "pin-pull" maneuver, while an electromagnetic motion detection system recorded the hand motion. Radial task: Eight experts and 12 trainees performed palpatory radial artery access task on a radial access simulator. The trainees repeated the task with the nondominant hand. The experts were classified by their most frequent radial artery access technique as having either palpatory, ultrasound, or overall limited experience. The time, path length, and number of movements were calculated. Mann-Whitney U tests were used to compare the groups, and P.05 was considered significant.Sheath task: The experts took less time, had shorter path lengths, and used fewer movements than the trainees (11.7 seconds ± 3.3 vs 19.7 seconds ± 6.5, P.01; 1.1 m ± 0.3 vs 1.4 m ± 0.4, P.01; and 19.5 movements ± 8.5 vs 31.0 movements ± 8.0, P.01, respectively). Radial task: The experts took less time, had shorter path lengths, and used fewer movements than the trainees (24.2 seconds ± 10.6 vs 33.1 seconds ± 16.9, P.01; 2.0 m ± 0.5 vs 3.0 m ± 1.9, P.001; and 36.5 movements ± 15.0 vs 54.5 movements ± 28.0, P.001, respectively). The trainees had a shorter path length for their dominant hand than their nondominant hand (3.0 m ± 1.9 vs 3.5 m ± 1.9, P.05). The expert palpatory group had a shorter path length than the ultrasound and limited experience groups (1.8 m ± 0.4 vs 2.0 m ± 0.4 and 2.3 m ± 1.2, respectively, P.05).Electromagnetic hand motion tracking can differentiate between the expert and trainee operators for simulated interventional tasks.

Published
2021

38. Percutaneous Thermal Ablation for Hepatocellular Carcinoma

Author

Muneeb Ahmed and Jeffrey L. Weinstein

Subjects
medicine.medical_specialty, Percutaneous, business.industry, Hepatocellular carcinoma, medicine, Thermal ablation, Radiology, Nuclear Medicine and imaging, Radiology, Cardiology and Cardiovascular Medicine, medicine.disease, business
Published
2020

39. AI-assisted Optimization of the ECCE Tracking System at the Electron Ion Collider

Author

C. Fanelli, Z. Papandreou, K. Suresh, J.K. Adkins, Y. Akiba, A. Albataineh, M. Amaryan, I.C. Arsene, C. Ayerbe Gayoso, J. Bae, X. Bai, M.D. Baker, M. Bashkanov, R. Bellwied, F. Benmokhtar, V. Berdnikov, J.C. Bernauer, F. Bock, W. Boeglin, M. Borysova, E. Brash, P. Brindza, W.J. Briscoe, M. Brooks, S. Bueltmann, M.H.S. Bukhari, A. Bylinkin, R. Capobianco, W.-C. Chang, Y. Cheon, K. Chen, K.-F. Chen, K.-Y. Cheng, M. Chiu, T. Chujo, Z. Citron, E. Cline, E. Cohen, T. Cormier, Y. Corrales Morales, C. Cotton, J. Crafts, C. Crawford, S. Creekmore, C. Cuevas, J. Cunningham, G. David, C.T. Dean, M. Demarteau, S. Diehl, N. Doshita, R. Dupré, J.M. Durham, R. Dzhygadlo, R. Ehlers, L. El Fassi, A. Emmert, R. Ent, R. Fatemi, S. Fegan, M. Finger, J. Frantz, M. Friedman, I. Friscic, D. Gangadharan, S. Gardner, K. Gates, F. Geurts, R. Gilman, D. Glazier, E. Glimos, Y. Goto, N. Grau, S.V. Greene, A.Q. Guo, L. Guo, S.K. Ha, J. Haggerty, T. Hayward, X. He, O. Hen, D.W. Higinbotham, M. Hoballah, T. Horn, A. Hoghmrtsyan, P.-h.J. Hsu, J. Huang, G. Huber, A. Hutson, K.Y. Hwang, C.E. Hyde, M. Inaba, T. Iwata, H.S. Jo, K. Joo, N. Kalantarians, G. Kalicy, K. Kawade, S.J.D. Kay, A. Kim, B. Kim, C. Kim, M. Kim, Y. Kim, E. Kistenev, V. Klimenko, S.H. Ko, I. Korover, W. Korsch, G. Krintiras, S. Kuhn, C.-M. Kuo, T. Kutz, J. Lajoie, D. Lawrence, S. Lebedev, H. Lee, J.S.H. Lee, S.W. Lee, Y.-J. Lee, W. Li, W.B. Li, X. Li, Y.T. Liang, S. Lim, C.-H. Lin, D.X. Lin, K. Liu, M.X. Liu, K. Livingston, N. Liyanage, W.J. Llope, C. Loizides, E. Long, R.-S. Lu, Z. Lu, W. Lynch, S. Mantry, D. Marchand, M. Marcisovsky, C. Markert, P. Markowitz, H. Marukyan, P. McGaughey, M. Mihovilovic, R.G. Milner, A. Milov, Y. Miyachi, A. Mkrtchyan, P. Monaghan, R. Montgomery, D. Morrison, A. Movsisyan, H. Mkrtchyan, C. Munoz Camacho, M. Murray, K. Nagai, J. Nagle, I. Nakagawa, C. Nattrass, D. Nguyen, S. Niccolai, R. Nouicer, G. Nukazuka, M. Nycz, V.A. Okorokov, S. Orešić, J.D. Osborn, C. O’Shaughnessy, S. Paganis, S.F. Pate, M. Patel, C. Paus, G. Penman, M.G. Perdekamp, D.V. Perepelitsa, H. Periera da Costa, K. Peters, W. Phelps, E. Piasetzky, C. Pinkenburg, I. Prochazka, T. Protzman, M.L. Purschke, J. Putschke, J.R. Pybus, R. Rajput-Ghoshal, J. Rasson, B. Raue, K.F. Read, K. Røed, R. Reed, J. Reinhold, E.L. Renner, J. Richards, C. Riedl, T. Rinn, J. Roche, G.M. Roland, G. Ron, M. Rosati, C. Royon, J. Ryu, S. Salur, N. Santiesteban, R. Santos, M. Sarsour, J. Schambach, A. Schmidt, N. Schmidt, C. Schwarz, J. Schwiening, R. Seidl, A. Sickles, P. Simmerling, S. Sirca, D. Sharma, Z. Shi, T.-A. Shibata, C.-W. Shih, S. Shimizu, U. Shrestha, K. Slifer, K. Smith, D. Sokhan, R. Soltz, W. Sondheim, J. Song, I.I. Strakovsky, P. Steinberg, P. Stepanov, J. Stevens, J. Strube, P. Sun, X. Sun, V. Tadevosyan, W.-C. Tang, S. Tapia Araya, S. Tarafdar, L. Teodorescu, D. Thomas, A. Timmins, L. Tomasek, N. Trotta, R. Trotta, T.S. Tveter, E. Umaka, A. Usman, H.W. van Hecke, C. Van Hulse, J. Velkovska, E. Voutier, P.K. Wang, Q. Wang, Y. Wang, D.P. Watts, N. Wickramaarachchi, L. Weinstein, M. Williams, C.-P. Wong, L. Wood, M.H. Wood, C. Woody, B. Wyslouch, Z. Xiao, Y. Yamazaki, Y. Yang, Z. Ye, H.D. Yoo, M. Yurov, N. Zachariou, W.A. Zajc, W. Zha, J.-L. Zhang, J.-X. Zhang, Y. Zhang, Y.-X. Zhao, X. Zheng, P. Zhuang, HEP, INSPIRE, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
FOS: Computer and information sciences, Nuclear and High Energy Physics, Computer Science - Machine Learning, Physics - Instrumentation and Detectors, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [INFO] Computer Science [cs], Machine Learning (cs.LG), High Energy Physics - Experiment, Brookhaven Lab, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [INFO]Computer Science [cs], tracking detector, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], evolutionary algorithms, Nuclear Experiment (nucl-ex), numerical calculations, Instrumentation, Nuclear Experiment, detector: design, Bayesian optimization, Instrumentation and Detectors (physics.ins-det), tracking, Computational Physics (physics.comp-ph), artificial intelligence, electron nucleus: colliding beams, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], ECCE, Physics - Computational Physics, electron ion collider, performance
Abstract

The Electron-Ion Collider (EIC) is a cutting-edge accelerator facility that will study the nature of the "glue" that binds the building blocks of the visible matter in the universe. The proposed experiment will be realized at Brookhaven National Laboratory in approximately 10 years from now, with detector design and R&D currently ongoing. Notably, EIC is one of the first large-scale facilities to leverage Artificial Intelligence (AI) already starting from the design and R&D phases. The EIC Comprehensive Chromodynamics Experiment (ECCE) is a consortium that proposed a detector design based on a 1.5T solenoid. The EIC detector proposal review concluded that the ECCE design will serve as the reference design for an EIC detector. Herein we describe a comprehensive optimization of the ECCE tracker using AI. The work required a complex parametrization of the simulated detector system. Our approach dealt with an optimization problem in a multidimensional design space driven by multiple objectives that encode the detector performance, while satisfying several mechanical constraints. We describe our strategy and show results obtained for the ECCE tracking system. The AI-assisted design is agnostic to the simulation framework and can be extended to other sub-detectors or to a system of sub-detectors to further optimize the performance of the EIC detector., 16 pages, 18 figures, 2 appendices, 3 tables

Published
2022

40. Scientific Computing Plan for the ECCE Detector at the Electron Ion Collider

Author

J.C. Bernauer, C.T. Dean, C. Fanelli, J. Huang, K. Kauder, D. Lawrence, J.D. Osborn, C. Paus, J.K. Adkins, Y. Akiba, A. Albataineh, M. Amaryan, I.C. Arsene, C. Ayerbe Gayoso, J. Bae, X. Bai, M.D. Baker, M. Bashkanov, R. Bellwied, F. Benmokhtar, V. Berdnikov, F. Bock, W. Boeglin, M. Borysova, E. Brash, P. Brindza, W.J. Briscoe, M. Brooks, S. Bueltmann, M.H.S. Bukhari, A. Bylinkin, R. Capobianco, W.-C. Chang, Y. Cheon, K. Chen, K.-F. Chen, K.-Y. Cheng, M. Chiu, T. Chujo, Z. Citron, E. Cline, E. Cohen, T. Cormier, Y. Corrales Morales, C. Cotton, J. Crafts, C. Crawford, S. Creekmore, C. Cuevas, J. Cunningham, G. David, M. Demarteau, S. Diehl, N. Doshita, R. Dupré, J.M. Durham, R. Dzhygadlo, R. Ehlers, L. El Fassi, A. Emmert, R. Ent, R. Fatemi, S. Fegan, M. Finger, J. Frantz, M. Friedman, I. Friscic, D. Gangadharan, S. Gardner, K. Gates, F. Geurts, R. Gilman, D. Glazier, E. Glimos, Y. Goto, N. Grau, S.V. Greene, A.Q. Guo, L. Guo, S.K. Ha, J. Haggerty, T. Hayward, X. He, O. Hen, D.W. Higinbotham, M. Hoballah, T. Horn, A. Hoghmrtsyan, P.-h.J. Hsu, G. Huber, A. Hutson, K.Y. Hwang, C. Hyde, M. Inaba, T. Iwata, H.S. Jo, K. Joo, N. Kalantarians, G. Kalicy, K. Kawade, S.J.D. Kay, A. Kim, B. Kim, C. Kim, M. Kim, Y. Kim, E. Kistenev, V. Klimenko, S.H. Ko, I. Korover, W. Korsch, G. Krintiras, S. Kuhn, C.-M. Kuo, T. Kutz, J. Lajoie, S. Lebedev, H. Lee, J.S.H. Lee, S.W. Lee, Y.-J. Lee, W. Li, X. Li, Y.T. Liang, S. Lim, C.-h. Lin, D.X. Lin, K. Liu, M.X. Liu, K. Livingston, N. Liyanage, W.J. Llope, C. Loizides, E. Long, R.-S. Lu, Z. Lu, W. Lynch, D. Marchand, M. Marcisovsky, P. Markowitz, H. Marukyan, P. McGaughey, M. Mihovilovic, R.G. Milner, A. Milov, Y. Miyachi, A. Mkrtchyan, P. Monaghan, R. Montgomery, D. Morrison, A. Movsisyan, H. Mkrtchyan, C. Munoz Camacho, M. Murray, K. Nagai, J. Nagle, I. Nakagawa, C. Nattrass, D. Nguyen, S. Niccolai, R. Nouicer, G. Nukazuka, M. Nycz, V.A. Okorokov, S. Orešić, C. O’Shaughnessy, S. Paganis, Z. Papandreou, S.F. Pate, M. Patel, G. Penman, M.G. Perdekamp, D.V. Perepelitsa, H. Periera da Costa, K. Peters, W. Phelps, E. Piasetzky, C. Pinkenburg, I. Prochazka, T. Protzman, M.L. Purschke, J. Putschke, J.R. Pybus, R. Rajput-Ghoshal, J. Rasson, B. Raue, K. Read, K. Røed, R. Reed, J. Reinhold, E.L. Renner, J. Richards, C. Riedl, T. Rinn, J. Roche, G.M. Roland, G. Ron, M. Rosati, C. Royon, J. Ryu, S. Salur, N. Santiesteban, R. Santos, M. Sarsour, J. Schambach, A. Schmidt, N. Schmidt, C. Schwarz, J. Schwiening, R. Seidl, A. Sickles, P. Simmerling, S. Sirca, D. Sharma, Z. Shi, T.-A. Shibata, C.-W. Shih, S. Shimizu, U. Shrestha, K. Slifer, K. Smith, D. Sokhan, R. Soltz, W. Sondheim, J. Song, I.I. Strakovsky, P. Steinberg, P. Stepanov, J. Stevens, J. Strube, P. Sun, X. Sun, K. Suresh, V. Tadevosyan, W.-C. Tang, S. Tapia Araya, S. Tarafdar, L. Teodorescu, A. Timmins, L. Tomasek, N. Trotta, R. Trotta, T.S. Tveter, E. Umaka, A. Usman, H.W. van Hecke, C. Van Hulse, J. Velkovska, E. Voutier, P.K. Wang, Q. Wang, Y. Wang, D.P. Watts, N. Wickramaarachchi, L. Weinstein, M. Williams, C.-P. Wong, L. Wood, M.H. Wood, C. Woody, B. Wyslouch, Z. Xiao, Y. Yamazaki, Y. Yang, Z. Ye, H.D. Yoo, M. Yurov, N. Zachariou, W.A. Zajc, J. Zhang, Y. Zhang, Y.X. Zhao, X. Zheng, P. Zhuang, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, data acquisition, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], programming, computer: network, High Energy Physics - Experiment, Brookhaven Lab, High Energy Physics - Experiment (hep-ex), data compilation, quantum chromodynamics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [INFO]Computer Science [cs], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment (nucl-ex), numerical calculations, Instrumentation, Nuclear Experiment, activity report, track data analysis, Instrumentation and Detectors (physics.ins-det), Computational Physics (physics.comp-ph), artificial intelligence, calibration, detector: proposed, electron nucleus: colliding beams, federated computing, data management, Physics - Computational Physics, electron ion collider, Jefferson Lab
Abstract

This is the arXiv pre-print which has not been peer reviewed. It is made available under a Creative Commons (CC BY) Attribution Lciense. The corrected version of record is available at: https://doi.org/10.1016/j.nima.2022.167859. Cite as: arXiv:2205.08607 [physics.ins-det] (or arXiv:2205.08607v1 [physics.ins-det] for this version) https://doi.org/10.48550/arXiv.2205.08607 Focus to learn more Journal reference: NIMA 1047, 167859 (2023) Related DOI: https://doi.org/10.1016/j.nima.2022.167859 Focus to learn more Submission history From: Joseph Osborn [view email] [v1] Tue, 17 May 2022 19:53:56 UTC (29,605 KB) Copyright © 2022 The Author(s). The Electron Ion Collider (EIC) is the next generation of precision QCD facility to be built at Brookhaven National Laboratory in conjunction with Thomas Jefferson National Laboratory. There are a significant number of software and computing challenges that need to be overcome at the EIC. During the EIC detector proposal development period, the ECCE consortium began identifying and addressing these challenges in the process of producing a complete detector proposal based upon detailed detector and physics simulations. In this document, the software and computing efforts to produce this proposal are discussed; furthermore, the computing and software model and resources required for the future of ECCE are described. Office of Nuclear Physics in the Office of Science in the Department of Energy, USA; National Science Foundation, USA; Los Alamos National Laboratory Laboratory Directed Research and Development (LDRD), USA 20200022DR.

Published
2022

41. There's More to Consider Than Thoracic Spine Height—The Case for Primary Spine Fusion in Older Early-onset Scoliosis Patients

Author

Joshua B. Holt, Lori A. Dolan, and Stuart L. Weinstein

Subjects
Pediatrics, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Thoracic spine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, Spine, Thoracic Vertebrae, Spinal Fusion, Treatment Outcome, Spine fusion, Scoliosis, Humans, Medicine, Orthopedics and Sports Medicine, Neurology (clinical), business, Early onset scoliosis, Aged
Published
2020

42. From Intention to Action: Operationalizing AGA Diversity Policy to Combat Racism and Health Disparities in Gastroenterology

Author

Michael L. Weinstein, Rotonya M. Carr, Peter A. Margolis, Jeff Springer, Lisa M. Gangarosa, M. Bishr Omary, Maria T. Abreu, Sandra M. Quezada, Byron Cryer, Kathleen Teixeira, and Thomas J Serena

Subjects
Biomedical Research, media_common.quotation_subject, Personnel selection, Criminology, Social Inclusion, Racism, Article, Cultural diversity, Political science, Humans, Healthcare Disparities, Personnel Selection, Policy Making, Societies, Medical, media_common, Health Equity, Hepatology, Gastroenterology, Health services research, Cultural Diversity, Culturally Competent Care, Health equity, Race Factors, Action (philosophy), Committee Membership, Health Services Research, Diversity (politics)
Published
2020

43. Extrahepatic transarterial radioembolization to treat fibrolamellar hepatocellular carcinoma: A case report

Author

Muneeb Ahmed, Ammar Sarwar, Damir Ljuboja, and Jeffrey L. Weinstein

Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, Liver tumor, Tare weight, lcsh:R895-920, Disease, Transarterial Radioembolization, Extrahepatic, 030218 nuclear medicine & medical imaging, TARE, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Yttrium-90 radioembolization, Case report, medicine, Radiology, Nuclear Medicine and imaging, business.industry, Fibrolamellar hepatocellular carcinoma, Advanced stage, medicine.disease, Early adolescents, Radiology, business, 030217 neurology & neurosurgery
Abstract

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare primary liver tumor that typically presents at an advanced stage in early adolescents and adults with no underlying liver disease. Surgical resection is the first-line treatment, and patients who are not surgical candidates face limited treatment options with poor long-term outcomes. Herein we report the first documented, technically successful treatment of FL-HCC with extrahepatic spread using transarterial radioembolization (TARE) in a 16-year-old male patient with surgically unresectable disease. Subsequent imaging revealed tumor necrosis and a 20% reduction in size, and the patient survived 20 months post-treatment, a marked improvement relative to historical data in the literature. Further research should examine the potential role of yttrium-90 TARE in the treatment of FL-HCC patients with metastatic disease.

Published
2020

44. Yttrium-90 radioembolization using MIRD dosimetry with resin microspheres

Author

Muneeb Ahmed, A. Ali, Salomao Faintuch, Raza Malik, Andrea J. Bullock, Ammar Sarwar, Jeffrey L. Weinstein, Michael P. Curry, Khalid Khwaja, and Alexei Kudla

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Interventional radiology, General Medicine, Resin microsphere, 030218 nuclear medicine & medical imaging, Microsphere, 03 medical and health sciences, Safety profile, 0302 clinical medicine, 030220 oncology & carcinogenesis, Absorbed dose, Medicine, Dosimetry, Radiology, Nuclear Medicine and imaging, Radiology, Embolization, business, Radiation Pneumonitis
Abstract

To review the technical feasibility of resin microsphere (SIR-Spheres®) yttrium-90 radioembolization prescribed using the medical internal radiation dose (MIRD) model. All radioembolization procedures for hepatic malignancies using resin microspheres with MIRD model between November 2015 and February 2019 were included in this IRB-approved study (n = 60). Student’s T test was used to compare prescribed activity based on MIRD and BSA models. Adverse events were assessed immediately, 30 days, and 6 months post-treatment. Sixty radioembolizations were performed in 54 patients (age 68 ± 9 years, 48–87 years, 35% female). Mean prescribed activity calculated by the MIRD model (target absorbed dose 120–200 Gy for primary and 80–200 Gy for metastatic liver cancers) was 1.7 GBq (0.3–6.4) compared with 0.6 GBq (0.12–2.1) if BSA had been used (p

Published
2020

46. More severe thoracic idiopathic scoliosis is associated with a greater three-dimensional loss of thoracic kyphosis

Author

Lori A. Dolan, Stuart L. Weinstein, Carrie E. Bartley, Thomas Barrett Sullivan, Peter O Newton, and Tracey P. Bastrom

Subjects
030222 orthopedics, medicine.medical_specialty, business.industry, Radiography, Kyphosis, Scoliosis, medicine.disease, Sagittal plane, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Coronal plane, Orthopedic surgery, Cohort, Deformity, medicine, Orthopedics and Sports Medicine, medicine.symptom, business, Nuclear medicine, 030217 neurology & neurosurgery
Abstract

Retrospective. Utilize three-dimensional (3D) measurements to assess the relationship between thoracic scoliosis severity and thoracic kyphosis in a large, multicenter cohort, and determine impact of 3D measurements on adolescent idiopathic scoliosis (AIS) curve classification. Research has demonstrated differences in two-dimensional (2D) and 3D assessment of the sagittal plane deformity in AIS. A prior smaller, single-institution study demonstrated an association between scoliosis severity and loss of 3D thoracic kyphosis. Data included retrospective compilation of prospectively enrolled bracing candidates and prospectively enrolled surgical candidates with thoracic AIS. Analysis included two groups based on thoracic curve magnitude: moderate (20–45°) and severe (> 45°). Imaging was performed using 2D radiographs. 3D thoracic kyphosis was calculated using a 2D to 3D conversion formula. Kyphosis was categorized according to the Lenke classification sagittal plane modifier. Analysis included 3032 patients. 2D kyphosis was significantly less in the moderate group (21 ± 12 vs 23 ± 14, p = 0.028). However, estimated 3D kyphosis was significantly greater in the moderate group (13 ± 10 vs 5 ± 12, p

Published
2020

47. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

Author

Dimitrios Farmakiotis, Susie Owenby, Arturo Loaiza-Bonilla, Mansi R. Shah, Matthew Puc, Vadim S. Koshkin, Ahmad Daher, Prakash Peddi, Cameron Rink, Heloisa P. Soares, Eneida R. Nemecek, Mehmet Asim Bilen, Sanjay Mishra, Lidia Schapira, Amit Verma, Ali Raza Khaki, Chih-Yuan Hsu, Sandy DiLullo, Mark Bonnen, Jeanna Knoble, Carla Casulo, Umit Topaloglu, Jorge A. Garcia, Geoffrey Shouse, Praveen Vikas, Clarke A. Low, Archana Ajmera, George D. Demetri, Leyre Zubiri, Grace Glace, Shannon K. McWeeney, Susan Yackzan, Pamela C Egan, Rachel P. Rosovsky, Salvatore Del Prete, Anthony P. Gulati, Lane R. Rosen, Andy Futreal, Merry Jennifer Markham, Sabitha Prabhakaran, Alicia K. Morgans, Sarah Nagle, Lisa Weissmann, Albert C. Yeh, Ziad Bakouny, Stephanie Berg, David Gill, Marcus Messmer, Ryan Nguyen, Terence Duane Rhodes, Vikram M. Narayan, Matthew D. Galsky, Arielle Elkrief, Lori J. Rosenstein, Roy S. Herbst, Justin Shaya, Thorvardur R. Halfdanarson, Douglas B. Johnson, Orestis A. Panagiotou, Sanjay G. Revankar, Toni K. Choueiri, Yu Shyr, Fiona Busser, Kaitlin M. Kelleher, Nicole M. Kuderer, Paul L. Weinstein, Anup Kasi, Grace Shaw, Adam J. Olszewski, Catherine Curran, Samuel M. Rubinstein, Angelo Cabal, Michael H. Bar, John F. Deeken, Vivek Subbiah, Abdul Hai Mansoor, Hina Khan, Rana R. McKay, Catherine Stratton, Saurabh Dahiya, Marc A. Rovito, John Philip, Sanjay Shete, Oscar K. Serrano, Julie Fu, Daniel W. Bowles, Candice Schwartz, Tian Zhang, Pier Vitale Nuzzo, Eric H. Bernicker, Wenxin Xu, Genevieve M. Boland, Sarah Wall, Babar Bashir, Solange Peters, Neeta K. Venepalli, Sandeep H. Mashru, William A. Wood, Anne H. Angevine, Mary F. Mulcahy, Gilberto Lopes, Justin F. Gainor, Jessica Hawley, Monika Joshi, Christopher R. Friese, Navid Hafez, Heather H. Nelson, Gregory J. Riely, Jordan Kharofa, Nilo Azad, Chintan Shah, Gerald Batist, Mary Salazar, Rosemary Zacks, Alice Zhou, Lawrence E. Feldman, Paul Fu, Gary H. Lyman, Nathaniel Bouganim, John A. Steinharter, Shilpa Gupta, Matthias Weiss, Peter Paul Yu, Susan Van Loon, Jamie Stratton, Karen Vega-Luna, Tyler Masters, Christopher Lemmon, Aakash Desai, Bryan A. Faller, Jessica M. Clement, Zhuoer Xie, Keith Stockerl-Goldstein, Corrie A. Painter, Gabrielle Bouchard, Rulla M. Tamimi, Daruka Mahadevan, Rimma Belenkaya, Jill S. Barnholtz-Sloan, Jarushka Naidoo, Amelie G. Ramirez, Philip E. Lammers, Elizabeth A. Griffiths, Michael J. Gurley, X. Li, Jonathan Riess, Syed A. Ahmad, Daniel Blake Flora, Salma K. Jabbour, Jared D. Acoba, Neeraj Agarwal, Ang Li, Sarah Mushtaq, Firas Wehbe, Tanios Bekaii-Saab, Donald C. Vinh, Emily Hsu, Ryan Monahan, Petros Grivas, Harry Menon, John M. Nakayama, Janice M. Mehnert, Elizabeth Marie Wulff-Burchfield, Sara Matar, Paul E. Oberstein, Mary M. Pasquinelli, Axel Grothey, Jack West, John C. Leighton, Dawn L. Hershman, Leslie A. Fecher, Aditya Bardia, Sumit A. Shah, Barbara Logan, Kerry L. Reynolds, Michael A. Thompson, Robert L. Rice, Erin Cook, Trisha Wise-Draper, Christine Bestvina, Daniel Castellano, Paolo Caimi, K. M.Steve Lo, Ruben A. Mesa, Maheen Z. Abidi, Alvaro G. Menendez, Daniel G. Stover, Colleen Lewis, Bertrand Routy, Deborah B. Doroshow, Carmen C. Solorzano, M. Wasif Saif, Rohit Bishnoi, Michael Glover, David D. Chism, Briana Barrow, Christopher McNair, Dimpy P. Shah, Erin A. Gillaspie, Andrea J. Zimmer, Andrew Schmidt, Jessica K. Altman, Michelle Marcum, Rawad Elias, Balazs Halmos, Karen Stauffer, Gayathri Nagaraj, Ardaman Shergill, Mark E. Dailey, Catherine Handy Marshall, Pramod K. Srivastava, Shuchi Gulati, Alokkumar Jha, Mateo Bover Larroya, Mark A. Lewis, Young Soo Rho, James L. Chen, Eli Van Allen, Julie Tsu Yu Wu, Antonio Giordano, Amit Kulkarni, Joerg Rathmann, Donna R. Rivera, Narjust Duma, Maryam B. Lustberg, Theresa M. Carducci, Jeremy L. Warner, Elizabeth Robilotti, Patricia LoRusso, Rohit Jain, Amit Sanyal, Nizar M. Tannir, Kent Hoskins, Nathan A. Pennell, Brian I. Rini, Suki Subbiah, COVID-19 and Cancer Consortium, Abidi, M., Acoba, J.D., Agarwal, N., Ahmad, S., Ajmera, A., Altman, J., Angevine, A.H., Azad, N., Bar, M.H., Bardia, A., Barnholtz-Sloan, J., Barrow, B., Bashir, B., Belenkaya, R., Berg, S., Bernicker, E.H., Bestvina, C., Bishnoi, R., Boland, G., Bonnen, M., Bouchard, G., Bowles, D.W., Busser, F., Cabal, A., Caimi, P., Carducci, T., Casulo, C., Chen, J.L., Clement, J.M., Chism, D., Cook, E., Curran, C., Daher, A., Dailey, M., Dahiya, S., Deeken, J., Demetri, G.D., DiLullo, S., Duma, N., Elias, R., Faller, B., Fecher, L.A., Feldman, L.E., Friese, C.R., Fu, P., Fu, J., Futreal, A., Gainor, J., Garcia, J., Gill, D.M., Gillaspie, E.A., Giordano, A., Glace, M.G., Grothey, A., Gulati, S., Gurley, M., Halmos, B., Herbst, R., Hershman, D., Hoskins, K., Jain, R.K., Jabbour, S., Jha, A., Johnson, D.B., Joshi, M., Kelleher, K., Kharofa, J., Khan, H., Knoble, J., Koshkin, V.S., Kulkarni, A.A., Lammers, P.E., Leighton, J.C., Lewis, M.A., Li, X., Li, A., Lo, KMS, Loaiza-Bonilla, A., LoRusso, P., Low, C.A., Lustberg, M.B., Mahadevan, D., Mansoor, A.H., Marcum, M., Markham, M.J., Handy Marshall, C., Mashru, S.H., Matar, S., McNair, C., McWeeney, S., Mehnert, J.M., Menendez, A., Menon, H., Messmer, M., Monahan, R., Mushtaq, S., Nagaraj, G., Nagle, S., Naidoo, J., Nakayama, J.M., Narayan, V., Nelson, H.H., Nemecek, E.R., Nguyen, R., Nuzzo, P.V., Oberstein, P.E., Olszewski, A.J., Owenby, S., Pasquinelli, M.M., Philip, J., Prabhakaran, S., Puc, M., Ramirez, A., Rathmann, J., Revankar, S.G., Rho, Y.S., Rhodes, T.D., Rice, R.L., Riely, G.J., Riess, J., Rink, C., Robilotti, E.V., Rosenstein, L., Routy, B., Rovito, M.A., Saif, M.W., Sanyal, A., Schapira, L., Schwartz, C., Serrano, O., Shah, M., Shah, C., Shaw, G., Shergill, A., Shouse, G., Soares, H.P., Solorzano, C.C., Srivastava, P.K., Stauffer, K., Stover, D.G., Stratton, J., Stratton, C., Subbiah, V., Tamimi, R., Tannir, N.M., Topaloglu, U., Van Allen, E., Van Loon, S., Vega-Luna, K., Venepalli, N., Verma, A.K., Vikas, P., Wall, S., Weinstein, P.L., Weiss, M., Wise-Draper, T., Wood, W.A., Xu, W.V., Yackzan, S., Zacks, R., Zhang, T., Zimmer, A.J., and West, J.

Subjects
Prognostic variable, medicine.medical_specialty, business.industry, Cancer, General Medicine, Odds ratio, Aged, Antiviral Agents/therapeutic use, Azithromycin/therapeutic use, Betacoronavirus, Cause of Death, Comorbidity, Coronavirus Infections/drug therapy, Coronavirus Infections/epidemiology, Coronavirus Infections/mortality, Databases, Factual, Female, Humans, Hydroxychloroquine/therapeutic use, Male, Middle Aged, Neoplasms/epidemiology, Neoplasms/mortality, Neoplasms/therapy, Pandemics, Pneumonia, Viral/drug therapy, Pneumonia, Viral/epidemiology, Pneumonia, Viral/mortality, Prognosis, Risk Factors, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Cohort, Clinical endpoint, Medicine, 030212 general & internal medicine, business, Cause of death, Cohort study
Abstract

Summary Background Data on patients with COVID-19 who have cancer are lacking. Here we characterise the outcomes of a cohort of patients with cancer and COVID-19 and identify potential prognostic factors for mortality and severe illness. Methods In this cohort study, we collected de-identified data on patients with active or previous malignancy, aged 18 years and older, with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from the USA, Canada, and Spain from the COVID-19 and Cancer Consortium (CCC19) database for whom baseline data were added between March 17 and April 16, 2020. We collected data on baseline clinical conditions, medications, cancer diagnosis and treatment, and COVID-19 disease course. The primary endpoint was all-cause mortality within 30 days of diagnosis of COVID-19. We assessed the association between the outcome and potential prognostic variables using logistic regression analyses, partially adjusted for age, sex, smoking status, and obesity. This study is registered with ClinicalTrials.gov, NCT04354701, and is ongoing. Findings Of 1035 records entered into the CCC19 database during the study period, 928 patients met inclusion criteria for our analysis. Median age was 66 years (IQR 57–76), 279 (30%) were aged 75 years or older, and 468 (50%) patients were male. The most prevalent malignancies were breast (191 [21%]) and prostate (152 [16%]). 366 (39%) patients were on active anticancer treatment, and 396 (43%) had active (measurable) cancer. At analysis (May 7, 2020), 121 (13%) patients had died. In logistic regression analysis, independent factors associated with increased 30-day mortality, after partial adjustment, were: increased age (per 10 years; partially adjusted odds ratio 1·84, 95% CI 1·53–2·21), male sex (1·63, 1·07–2·48), smoking status (former smoker vs never smoked: 1·60, 1·03–2·47), number of comorbidities (two vs none: 4·50, 1·33–15·28), Eastern Cooperative Oncology Group performance status of 2 or higher (status of 2 vs 0 or 1: 3·89, 2·11–7·18), active cancer (progressing vs remission: 5·20, 2·77–9·77), and receipt of azithromycin plus hydroxychloroquine (vs treatment with neither: 2·93, 1·79–4·79; confounding by indication cannot be excluded). Compared with residence in the US-Northeast, residence in Canada (0·24, 0·07–0·84) or the US-Midwest (0·50, 0·28–0·90) were associated with decreased 30-day all-cause mortality. Race and ethnicity, obesity status, cancer type, type of anticancer therapy, and recent surgery were not associated with mortality. Interpretation Among patients with cancer and COVID-19, 30-day all-cause mortality was high and associated with general risk factors and risk factors unique to patients with cancer. Longer follow-up is needed to better understand the effect of COVID-19 on outcomes in patients with cancer, including the ability to continue specific cancer treatments. Funding American Cancer Society, National Institutes of Health, and Hope Foundation for Cancer Research.

Published
2020

48. Deformity correction using proximal hooks and distal screws (PHDSs) improves radiological metrics in adolescent idiopathic scoliosis

Author

Stuart L. Weinstein, Pawin Gajaseni, Luca Labianca, Andrew J. Pugely, and Piyush Kalakoti

Subjects
Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Radiography, Bone Screws, Thoracic Vertebrae, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, medicine, Humans, Orthopedics and Sports Medicine, Retrospective Studies, Balance (ability), 030222 orthopedics, Cobb angle, business.industry, Repeated measures design, Surgery, Benchmarking, Spinal Fusion, Treatment Outcome, medicine.anatomical_structure, Bonferroni correction, Scoliosis, Clavicle, Spinal fusion, Radiological weapon, symbols, Female, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Surgical correction for AIS has evolved from all hooks to hybrids or all screw constructs. Limited literature exists reporting outcomes using PHDS for posterior spinal fusion (PSF). This is the largest series in evaluating results of PHDS technique. A retrospective review of consecutive AIS patients undergoing PSF by a single surgeon between 2006 and 2015 was performed. All eligible patients met a minimum 2-year follow-up. Patient demographics and radiographical parameters (radiographic shoulder height (RSH), T1 tilt, clavicle angle) at baseline, 6-week and 2-year post-operation were recorded. The primary outcome was difference in RSH from baseline measurements evaluated using repeated measures one-way analysis of variance with Bonferroni correction. A total of 219 patients (mean age at surgery: 13.68 years; 82% female) were included. The mean follow-up was 41.2 months (range 24–108 months). The RSH was significantly improved from − 14.7 ± 10.38 mm to 8.0 ± 6.9 mm (P

Published
2020

49. Closed Vs. Open Reduction/Salter Innominate Osteotomy for Developmental Hip Dislocation After Age 18 Months

Author

Elizabeth J Scott, Lori A. Dolan, and Stuart L. Weinstein

Subjects
Adult, Male, Reoperation, musculoskeletal diseases, medicine.medical_specialty, Arthroplasty, Replacement, Hip, medicine.medical_treatment, Osteoarthritis, Osteoarthritis, Hip, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Orthopedics and Sports Medicine, Pelvic Bones, Hip Dislocation, Congenital, Reduction (orthopedic surgery), Survival analysis, Aged, Hip surgery, 030222 orthopedics, business.industry, Proportional hazards model, Hazard ratio, Age Factors, Infant, 030229 sport sciences, General Medicine, Middle Aged, medicine.disease, Arthroplasty, Confidence interval, Closed Fracture Reduction, Osteotomy, Surgery, Open Fracture Reduction, Treatment Outcome, Child, Preschool, Developmental Dysplasia of the Hip, Female, business, Follow-Up Studies
Abstract

Background Despite widespread use of single-stage open reduction and pelvic osteotomy for treatment of developmental dysplasia of the hip (DDH) after walking age, this aggressive strategy remains controversial. We directly compared dislocated hips treated with closed reduction (CR) to those treated with open reduction and Salter innominate osteotomy (OR/IO) to estimate the relative hazard of total hip arthroplasty (THA) and the THA-free survival time. Methods In a series of patients 18 to 60 months of age, 45 patients (58 hips) underwent CR and 58 patients (78 hips) were treated with OR/IO and followed to a minimum 40 years post-reduction. Observations in the survival analysis were censored if no THA had occurred by 48 years. Multivariate Cox regression analysis was used to estimate the hazard of THA given treatment, age, and bilaterality. Complications and additional procedures were noted. Results At 48 years of follow-up, 29 (50%) of the hips survived after CR compared with 54 (69%) after OR/IO. At 45 years, the survival probability after OR/IO was 0.63 (95% confidence interval [CI] = 0.50 to 0.78) compared with 0.55 (95% CI = 0.43 to 0.72) after CR. The hazard ratio (HR) of THA was modeled as a function of treatment, age at reduction, and bilaterality. The effect of age and treatment on the outcome of hips in patients with unilateral involvement was minimal. However, age did significantly alter the relationship between treatment and outcome in bilateral cases. In the bilateral group, the predicted HR of THA was lower after CR in hips that were reduced at the age of 18 months (HR = 0.16, 95% CI = 0.04 to 0.64) but higher in those that were reduced at 36 months (HR = 4.23, 95% CI = 2.00 to 8.95). Additional procedures were indicated for 17% and 22% of hips after CR and OR/IO, respectively. Conclusions Osteoarthritis and THA was more likely after CR than OR/IO, but the data do not indicate a difference in unadjusted hip-survival time. In patients with bilateral disease, an older age at reduction was associated with an increased hazard of THA after CR than after OR/IO. Both treatments provided substantial benefit relative to the natural history of DDH, but THA is the expected outcome in middle adulthood. Level of evidence Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

Published
2020

50. Utilization and Outcomes of Thrombolytic Therapy for Acute Pulmonary Embolism

Author

Ido Weinberg, Brett J Carroll, Jeffrey L. Weinstein, Sebastian Beyer, Robert W. Yeh, Duane S. Pinto, Colby Shanafelt, Herbert D. Aronow, and Eric A. Secemsky

Subjects
Pulmonary and Respiratory Medicine, Mechanical ventilation, medicine.medical_specialty, Thrombolytic treatment, Practice patterns, business.industry, medicine.medical_treatment, Thrombolysis, Critical Care and Intensive Care Medicine, medicine.disease, Pulmonary embolism, Inverse probability of treatment weighting, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Internal medicine, medicine, In patient, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract

Background There are increased options to deliver thrombolytic treatment for acute, high-risk pulmonary embolism (PE). The goals of this study were to examine practice patterns of systemic thrombolysis and catheter-directed thrombolysis (CDT) and to compare outcomes following CDT with ultrasound facilitation (CDT-ultrasound) and CDT alone. Methods The study analyzed adults aged > 18 years with hospitalizations associated with acute PE and thrombolysis in the 2016 Nationwide Readmissions Database. The study identified characteristics associated with the use of systemic thrombolysis and CDT. Comparisons of CDT-ultrasound vs CDT alone were then made by evaluating in-hospital events and readmissions. The primary outcomes were in-hospital mortality and 30-day readmission rates. Results Among 5,436 hospitalizations, systemic thrombolysis was used more often (n = 3,376; 62.1%) than CDT (n = 2,060; 37.9%). Compared with CDT, systemic thrombolysis was used more frequently in patients with higher rates of vasopressor use (4.3% vs 1.0%), shock (15.8% vs. 6.9%), cardiac arrest (12.7% vs 3.4%), and mechanical ventilation (19.0% vs 5.9%). Among patients who underwent CDT, 417 (20.2%) received CDT-ultrasound, and 1,643 (79.8%) received CDT alone. Rates of bleeding events, vasopressor use, and mechanical ventilation were similar between therapeutic strategies. Following adjustment, in-hospital mortality (OR, 1.19; 95% CI, 0.63-2.26; P = .59) and 30-day readmission rates (OR, 0.75; 95% CI, 0.47-1.22; P = .25) were not significantly different between CDT-ultrasound and CDT alone. Conclusions Systemic thrombolysis is used more often than CDT in patients with acute PE, in particular among those with a greater prevalence of high-risk features. Among patients treated with CDT, there were no differences in events between CDT-ultrasound and CDT alone.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results