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2,202 results on '"López-Miranda, A."'

1. Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

Author

Baenas, I., Camacho-Barcia, L., Granero, R., Razquin, C., Corella, D., Gómez-Martínez, C., Castañer-Niño, O., Martínez, J. A., Alonso-Gómez, Á. M., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F. J., Lapetra, J., Serra-Majem, J. L., Cano-Ibáñez, N., Tur, J. A., Martín-Sánchez, V., Pintó, X., Gaforio, J. J., Matía-Martín, P., Vidal, J., Vázquez, C., Daimiel, L., Ros, E., Jiménez-Murcia, S., Dalsgaard, S., Garcia-Arellano, A., Babio, N., Sorli, J. V., Lassale, C., García-de-la-Hera, M., Gómez-García, E., Zulet, M. A., Konieczna, J., Martín-Peláez, S., Tojal-Sierra, L., Basterra-Gortari, F. J., de las Heras-Delgado, S., Portoles, O., Muñoz-Pérez, M. Á., Arenas-Larriva, A. P., Compañ-Gabucio, L., Eguaras, S., Shyam, S., Fitó, M., Baños, R. M., Salas-Salvadó, J., and Fernández-Aranda, F.

Published
2024
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3. Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial

Author

Shyam, Sangeetha, García-Gavilán, J. F., Paz-Graniel, I., Gaforio, J. J., Martínez-González, M. Á., Corella, D., Martínez, J. A., Alonso-Gómez, Á. M., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F. J., Lapetra, J., Serra-Majem, J. L., Bueno-Cavanillas, A., Tur, J. A., Sánchez, V. Martín, Pintó, X., Matía-Martín, P., Vidal, J., del Mar Alcarria, M., Daimiel, L., Ros, E., Fernandez-Aranda, F., Nishi, S. K., García-Regata, Ó., Araluce, R. Perez, Asensio, E. M., Castañer, O., Garcia-Rios, A., Oncina-Cánovas, A., Bouzas, C., Zulet, M. A., Rayó, E., Casas, R., Martin-Pelaez, S., Tojal-Sierra, L., Bernal-López, M. R., Carlos, S., Sorlí, J. V., Goday, A., Peña-Orihuela, P. J., Pastor-Morel, A., Eguaras, S., Zomeño, M. D., Delgado-Rodríguez, M., Babio, N., Fitó, M., and Salas-Salvadó, Jordi

Published
2023
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6. Sex-specific dietary patterns and their association with metabolic syndrome: Insights from a cross-sectional analysis

Author

Popescu, Mónica Lavinia, Rubín-García, María, Álvarez-Álvarez, Laura, Toledo, Estefanía, Corella, Dolores, Salas-Salvadó, Jordi, Pérez-Vega, Karla Alejandra, Martínez, J Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Cano-Ibáñez, Naomi, Tur, Josep A., Naveiro, Roi, Pintó, Xavier, Delgado-Rodríguez, Miguel, Ortiz-Ramos, María, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Vázquez-Ruiz, Zenaida, Babio, Nancy, Sorlí, Jose V., Castañer, Olga, García-Rios, Antonio, González-Palacios, Sandra, Zulet, María, Konieczna, Jadwiga, Casas, Rosa, Masso-Guijarro, Paloma, Tojal-Sierra, Lucas, Gómez-Pérez, Ana M., Cenoz-Osinaga, Juan Carlos, Valverde, Irene, Fernández-Carrión, Rebeca, Schröder, Helmut, Arenas Larriva, Antonio P., Torres-Collado, Laura, García-Arellano, Ana, Palau-Galindo, Antoni, Fitó, Montserrat, Martín-Sánchez, Vicente, and Fernández-Villa, Tania

Published
2024
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10. Strategies to Delay Ethylene-Mediated Ripening in Climacteric Fruits: Implications for Shelf Life Extension and Postharvest Quality

Author

Ramiro Alonso-Salinas, Santiago López-Miranda, Antonio José Pérez-López, and José Ramón Acosta-Motos

Subjects
delayed ripening, fruit preservation, phytohormone, Plant culture, SB1-1110
Abstract

Climacteric fruits undergo a characteristic ripening process regulated by ethylene, a key plant hormone. Extending the shelf life of these fruits while preserving their postharvest quality poses a significant challenge for the food industry. This review provides a comprehensive overview of physiological and molecular strategies to delay ethylene-mediated ripening in climacteric fruits and their impact on shelf life, postharvest quality, sensory attributes, and volatile compounds. Additionally, it examines the role of ethylene in fruit ripening, analysing various ethylene managing strategies including ethylene inhibitors, ethylene adsorbents, and ethylene scavengers by catalytic oxidation. This review concludes with future research directions including molecular and genetic approaches for reducing ethylene production or responsiveness in fruits, integrated strategies, environmental considerations, and commercial applications for improving postharvest handling and fruit quality.

Published
2024
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11. Objectively Measured Sleep Duration and Health-Related Quality of Life in Older Adults with Metabolic Syndrome: A One-Year Longitudinal Analysis of the PREDIMED-Plus Cohort

Author

Alba Marcos-Delgado, Vicente Martín-Sánchez, Miguel Ángel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Helmut Schröder, Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José M. Santos-Lozano, Jacqueline Álvarez-Pérez, Aurora Bueno-Cavanillas, Naomi Cano-Ibáñez, Carmen Amezcua-Prieto, Natalia Hernández-Segura, Josep A. Tur, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emili Ros, Estefanía Toledo, Tany E. Garcidueñas-Fimbres, Judith Viaplana, Eva M. Asensio, María D. Zomeño, Antonio Garcia-Rios, Alejandro Oncina-Cánovas, Francisco Javier Barón-López, Napoleón Pérez-Farinos, Carmen Sayon-Orea, Aina M. Galmés-Panadés, Rosa Casas, Lucas Tojal-Sierra, Ana M. Gómez-Pérez, Pilar Buil-Corsiales, Jesús F. García-Gavilán, Carolina Ortega-Azorín, Olga Castañer, Patricia J. Peña-Orihuela, Sandra González-Palacios, Nancy Babio, Montse Fitó, and Javier Nieto

Subjects
sleep duration, daytime sleep duration, metabolic syndrome, health-related quality of life, quality of life, nap, Nutrition. Foods and food supply, TX341-641
Abstract

The aim of our cross-sectional and longitudinal study is to assess the relationship between daytime and night-time sleep duration and health-related quality of life (HRQoL) in adults with metabolic syndrome after a 1-year healthy lifestyle intervention. Analysis of the data from 2119 Spanish adults aged 55–75 years from the PREDIMED-Plus study was performed. Sleep duration was assessed using a wrist-worn accelerometer. HRQoL was measured using the SF-36 questionnaire. Linear regression models adjusted for socioeconomic and lifestyle factors and morbidity were developed. In cross-sectional analyses, participants with extreme night-time sleep duration categories showed lower physical component summary scores in Models 1 and 2 [β-coefficient (95% confidence interval) p = 0.002. >9 h vs. 7–9 h: −1.1 (−2.0 to −0.3); p = 0.01]. Participants who sleep less than 7 h a night and take a nap are associated with higher mental component summary scores [β-coefficient (95% confidence interval) 6.3 (1.3 to 11.3); p = 0.01]. No differences between night-time sleep categories and 12-month changes in HRQoL were observed. In conclusion, in cross-sectional analyses, extremes in nocturnal sleep duration are related to lower physical component summary scores and napping is associated with higher mental component summary scores in older adults who sleep less than 7 h a night.

Published
2024
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15. Consenso sobre lipoproteína (a) de la Sociedad Española de Arteriosclerosis. Revisión bibliográfica y recomendaciones para la práctica clínica

Author

Delgado-Lista, Javier, Mostaza, Jose M., Arrobas-Velilla, Teresa, Blanco-Vaca, Francisco, Masana, Luis, Pedro-Botet, Juan, Perez-Martinez, Pablo, Civeira, Fernando, Cuende-Melero, Jose I., Gomez-Barrado, Jose J., Lahoz, Carlos, Pintó, Xavier, Suarez-Tembra, Manuel, Lopez-Miranda, Jose, and Guijarro, Carlos

Published
2024
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16. Effect of a nutritional intervention based on an energy-reduced Mediterranean diet on environmental impact

Author

Álvarez-Álvarez, Laura, Rubín-García, María, Vitelli-Storelli, Facundo, García, Silvia, Bouzas, Cristina, Martínez-González, Miguel Ángel, Corella, Dolores, Salas-Salvadó, Jordi, Malcampo, Mireia, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, García Fernández, Camino, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, García-Arellano, Ana, Martínez, María Ángeles, Sorlí, José V., Zomeño, María Dolores, García-Rios, Antonio, González-Palacios, Sandra, Monserrat-Mesquida, Margalida, Abete, Itziar, Colom Fernández, Antoni, Casas, Rosa, Cano Ibáñez, Naomi, Ugarriza, Lucía, Bernal-López, M. Rosa, Bes-Rastrollo, Maira, Paz-Graniel, Indira, Asensio, Eva M., Fitó, Montse, Arenas Larriva, Antonio P., Oncina-Cánovas, Alejandro, Vázquez, Zenaida, Fernández de la Puente, María, Pérez-Vega, Alejandra, Tur, Josep A., and Martín-Sánchez, Vicente

Published
2024
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17. SEA 2024 Standards for Global Control of Vascular Risk

Author

Mostaza, José María, Pintó, Xavier, Armario, Pedro, Masana, Luis, Real, José T., Valdivielso, Pedro, Arrobas-Velilla, Teresa, Baeza-Trinidad, Ramón, Calmarza, Pilar, Cebollada, Jesús, Civera-Andrés, Miguel, Cuende Melero, José I., Díaz-Díaz, José L., Espíldora-Hernández, Javier, Fernández Pardo, Jacinto, Guijarro, Carlos, Jericó, Carles, Laclaustra, Martín, Lahoz, Carlos, López-Miranda, José, Martínez-Hervás, Sergio, Muñiz-Grijalvo, Ovidio, Páramo, José A., Pascual, Vicente, Pedro-Botet, Juan, Pérez-Martínez, Pablo, and Puzo, José

Published
2024
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18. Estándares de la Sociedad Española de Arteriosclerosis 2024 para el control global del riesgo vascular

Author

Mostaza, José María, Pintó, Xavier, Armario, Pedro, Masana, Luis, Real, José T., Valdivielso, Pedro, Arrobas-Velilla, Teresa, Baeza-Trinidad, Ramón, Calmarza, Pilar, Cebollada, Jesús, Civera-Andrés, Miguel, Cuende Melero, José I., Díaz-Díaz, José L., Espíldora-Hernández, Javier, Fernández Pardo, Jacinto, Guijarro, Carlos, Jericó, Carles, Laclaustra, Martín, Lahoz, Carlos, López-Miranda, José, Martínez-Hervás, Sergio, Muñiz-Grijalvo, Ovidio, Páramo, José A., Pascual, Vicente, Pedro-Botet, Juan, Pérez-Martínez, Pablo, and Puzo, José

Published
2024
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19. Impact of mediterranean diet promotion on environmental sustainability: a longitudinal analysis

Author

Álvarez-Álvarez, L., Vitelli-Storelli, F., Rubín-García, M., García, S., Bouzas, C., Ruíz-Canela, M., Corella, D., Salas-Salvadó, J., Fitó, M., Martínez, J.A., Tojal-Sierra, L., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F.J., Santos-Lozano, J.M., Serra-Majem, L., Bueno-Cavanillas, A., García-Fernández, C., Esteve-Luque, V., Delgado-Rodríguez, M., Torrego-Ellacuría, M., Vidal, J., Prieto, L., Daimiel, L., Casas, R., García Arellano, A., Shyam, S., González, J.I., Castañer, O., García-Rios, A., Ortiz Díaz, F., Fernández, A.C., Sánchez-Villegas, A., Morey, M., Cano-Ibañez, N., Sorto-Sánchez, C., Bernal-López, M.R., Bes-Rastrollo, M., Nishi, S.K., Coltell, O., Zomeño, M.D., Peña-Orihuela, P.J., Aparicio, D.V., Zulet, M.A., Vázquez, Z., Babio, N., Pérez, K.A., Tur, J.A., and Martín-Sánchez, V.

Published
2024
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20. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Author

Shyam, Sangeetha, García-Gavilán, Jesús Francisco, Paz-Graniel, Indira, Gaforio, José J., Martínez-González, Miguel Ángel, Corella, Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sánchez, Vicente Martín, Pintó, Xavier, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Fernandez-Aranda, Fernando, Nishi, Stephanie K., Garcia-Regata, Oscar, Toledo, Estefania, Asensio, Eva M., Castañer, Olga, Garcia-Rios, Antonio, Torres-Collado, Laura, Gómez-Gracia, Enrique, Zulet, M. Angeles, Ruiz, Nuria Goñi, Casas, Rosa, Cano-Ibáñez, Naomi, Tojal-Sierra, Lucas, Gómez-Perez, A. M., Sorlí, Jose V., Cinza-Sanjurjo, Sergio, Martín-Peláez, Sandra, Peña-Orihuela, Patricia J., Oncina-Canovas, Alejandro, Perez-Araluce, Rafael, Zomeño, María Dolores, Chaplin, Alice, Delgado-Rodríguez, Miguel, Babio, Nancy, Fitó, Montserrat, and Salas-Salvadó, Jordi

Published
2023
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21. Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population

Author

Nadine Khoury, María Ángeles Martínez, Stephanie K. Nishi, Miguel Ángel Martínez-González, Dolores Corella, Olga Castañer, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Manuel Santos-Lozano, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Sergio Cinza Sanjurjo, Xavier Pintó, José Juan Gaforio, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Carmen Sayon-Orea, Jose V Sorli, Karla-Alejandra Pérez-Vega, Antonio Garcia-Rios, Francisco Ortiz-Díaz, Enrique Gómez-Gracia, MA Zulet, Alice Chaplin, Rosa Casas, Inmaculada Salcedo-Bellido, Lucas Tojal-Sierra, Maria-Rosa Bernal-Lopez, Zenaida Vazquez-Ruiz, Eva M. Asensio, Albert Goday, Patricia J. Peña-Orihuela, Antonio J. Signes-Pastor, Ana Garcia-Arellano, Montse Fitó, Nancy Babio, and Jordi Salas-Salvadó

Subjects
Perfluorooctane sulfonate (PFOS), Diabetes, Endocrine disruptors (EDs), Dietary intake, Glucose homeostasis parameters, Environmental sciences, GE1-350
Abstract

Background: Endocrine disruptors (EDs) have emerged as potential contributors to the development of type-2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food. Objective: To assess at baseline and after 1-year of follow-up associations between estimated dietary intake (DI) of PFOS, and glucose homeostasis parameters and body-mass-index (BMI) in a senior population of 4600 non-diabetic participants from the PREDIMED-plus study. Methods: Multivariable linear regression models were conducted to assess associations between baseline PFOS-DI at lower bound (LB) and upper bound (UB) established by the EFSA, glucose homeostasis parameters and BMI. Results: Compared to those in the lowest tertile, participants in the highest tertile of baseline PFOS-DI in LB and UB showed higher levels of HbA1c [β-coefficient(CI)] [0.01 %(0.002 to 0.026), and [0.06 mg/dL(0.026 to 0.087), both p-trend ≤ 0.001], and fasting plasma glucose in the LB PFOS-DI [1.05 mg/dL(0.050 to 2.046),p-trend = 0.022]. Prospectively, a positive association between LB of PFOS-DI and BMI [0.06 kg/m2(0.014 to 0.106) per 1-SD increment of energy-adjusted PFOS-DI was shown. Participants in the top tertile showed an increase in HOMA-IR [0.06(0.016 to 0.097), p-trend = 0.005] compared to participants in the reference tertile after 1-year of follow-up. Discussion: This is the first study to explore the association between DI of PFOS and glucose homeostasis. In this study, a high baseline DI of PFOS was associated with a higher levels of fasting plasma glucose and HbA1c and with an increase in HOMA-IR and BMI after 1-year of follow-up.

Published
2024
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22. Adults with excess weight or obesity, but not with overweight, report greater pain intensities than individuals with normal weight: a systematic review and meta-analysis

Author

Miguel M. Garcia, Patricia Corrales, Miguel Á. Huerta, Maciej J. Czachorowski, Visitación López-Miranda, Gema Medina-Gómez, Enrique J. Cobos, Carlos Goicoechea, and Miguel Molina-Álvarez

Subjects
obesity, overweight, pain scale, body mass index, prognosis, chronic disease, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

ContextOver 1.9 billion adult people have overweight or obesity. Considered as a chronic disease itself, obesity is associated with several comorbidities. Chronic pain affects approximately 60 million people and its connection with obesity has been displayed in several studies. However, controversial results showing both lower and higher pain thresholds in subjects with obesity compared to individuals with normal weight and the different parameters used to define such association (e.g., pain severity, frequency or duration) make it hard to draw straight forward conclusions in the matter. The objective of this article is to examine the relationship between overweight and obesity (classified with BMI as recommended by WHO) and self-perceived pain intensity in adults.MethodsA literature search was conducted following PRISMA guidelines using the databases CINAHL, Cochrane Library, EMBASE, PEDro, PubMed, Scopus and Web of Science to identify original studies that provide BMI values and their associated pain intensity assessed by self-report scales. Self-report pain scores were normalized and pooled within meta-analyses. The Cochrane’s Q test and I2 index were used to clarify the amount of heterogeneity; meta-regression was performed to explore the relationship between each outcome and the risk of bias.ResultsOf 2194 studies, 31 eligible studies were identified and appraised, 22 of which provided data for a quantitative analysis. The results herein suggested that adults with excess weight (BMI ≥ 25.0) or obesity (BMI ≥ 30.0) but not with overweight (pre-obesity) alone (BMI 25.0–29.9), are more likely to report greater intensities of pain than individuals of normal weight (BMI 18.5–24.9). Subgroup analyses regarding the pathology of the patients showed no statistically significant differences between groups. Also, influence of age in the effect size, evaluated by meta-regression, was only observed in one of the four analyses. Furthermore, the robustness of the findings was supported by two different sensitivity analyses.ConclusionSubjects with obesity and excess weight, but not overweight, reported greater pain intensities than individuals with normal weight. This finding encourages treatment of obesity as a component of pain management. More research is required to better understand the mechanisms of these differences and the clinical utility of the findings.Systematic Review Registrationhttps://doi.org/10.17605/OSF.IO/RF2G3, identifier OSF.IO/RF2G3.

Published
2024
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23. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Author

Sangeetha Shyam, Jesús Francisco García-Gavilán, Indira Paz-Graniel, José J. Gaforio, Miguel Ángel Martínez-González, Dolores Corella, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, J. Luís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín Sánchez, Xavier Pintó, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia-Regata, Estefania Toledo, Eva M. Asensio, Olga Castañer, Antonio Garcia-Rios, Laura Torres-Collado, Enrique Gómez-Gracia, M. Angeles Zulet, Nuria Goñi Ruiz, Rosa Casas, Naomi Cano-Ibáñez, Lucas Tojal-Sierra, A. M. Gómez-Perez, Jose V. Sorlí, Sergio Cinza-Sanjurjo, Sandra Martín-Peláez, Patricia J. Peña-Orihuela, Alejandro Oncina-Canovas, Rafael Perez-Araluce, María Dolores Zomeño, Alice Chaplin, Miguel Delgado-Rodríguez, Nancy Babio, Montserrat Fitó, and Jordi Salas-Salvadó

Subjects
Obesity, COVID-19, Older adults, Weight loss, Central obesity, Medicine
Abstract

Abstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods This analysis included 6874 men and women (aged 55–75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5–6 years before the pandemic and their changes at the visit prior to censoring. Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19. Trial registration This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).

Published
2023
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24. Comprensión y prevención de los enfrentamientos violentos entre jóvenes en el Distrito de Barranquilla, Colombia

Author

María Molinares-Torres, Deisy Bautista-Flórez, and Sergio López-Miranda

Subjects
conflict, youth, opportunities, prevention, violence, Criminal law and procedure, K5000-5582, Social pathology. Social and public welfare. Criminology, HV1-9960
Abstract

The objective of this work is to demonstrate, from a double vision (interviews carried out with young people who participated in violent confrontations and the review of what was proposed from the theory), new elements that allow identifying and addressing the main social, economic, cultural factors. , among others, that lead to these confrontations; Thus, the role of the family, school, neighborhood and peer group in its prevention is evident. This analysis makes possible the study of the general principles and postulates established by various international institutions in matters of prevention and their inclusion and adaptation in the actions and strategies adopted by the Administration of Barranquilla and the impact that these have generated on young people.

Published
2023
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25. Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population

Author

Khoury, Nadine, Ángeles Martínez, María, Nishi, Stephanie K., Ángel Martínez-González, Miguel, Corella, Dolores, Castañer, Olga, Alfredo Martínez, J., Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Manuel Santos-Lozano, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Cinza Sanjurjo, Sergio, Pintó, Xavier, Juan Gaforio, José, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, V Sorli, Jose, Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Ortiz-Díaz, Francisco, Gómez-Gracia, Enrique, Zulet, MA, Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vazquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, and Salas-Salvadó, Jordi

Published
2024
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26. Laparoscopic Sleeve Gastrectomy in Patients with Severe Obesity Restores Adaptive Responses Leading to Nonalcoholic Steatohepatitis

Author

Cabré, Noemí, Luciano-Mateo, Fedra, Chapski, Douglas J, Baiges-Gaya, Gerard, Fernández-Arroyo, Salvador, Hernández-Aguilera, Anna, Castañé, Helena, Rodríguez-Tomàs, Elisabet, París, Marta, Sabench, Fàtima, Del Castillo, Daniel, del Bas, Josep M, Tomé, Mercedes, Bodineau, Clément, Sola-García, Alejandro, López-Miranda, José, Martín-Montalvo, Alejandro, Durán, Raúl V, Vondriska, Thomas M, Rosa-Garrido, Manuel, Camps, Jordi, Menéndez, Javier A, and Joven, Jorge

Subjects
Biochemistry and Cell Biology, Biological Sciences, Obesity, Clinical Research, Liver Disease, Chronic Liver Disease and Cirrhosis, Human Genome, Digestive Diseases, Biotechnology, Genetics, Hepatitis, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Gastrectomy, Humans, Ketoglutaric Acids, Laparoscopy, Non-alcoholic Fatty Liver Disease, Obesity, Morbid, TOR Serine-Threonine Kinases, bariatric surgery, DNA methylation, energy metabolism, epigenetics, functional studies, glutaminolysis, multi-omics approach, Other Chemical Sciences, Other Biological Sciences, Chemical Physics, Biochemistry and cell biology, Microbiology, Medicinal and biomolecular chemistry
Abstract

The surgically induced remission of liver disease represents a model to investigate the signalling processes that trigger the development of nonalcoholic steatohepatitis with the aim of identifying novel therapeutic targets. We recruited patients with severe obesity with or without nonalcoholic steatohepatitis and obtained liver and plasma samples before and after laparoscopic sleeve gastrectomy for immunoblotting, immunocytochemical, metabolomic, transcriptomic and epigenetic analyses. Functional studies were performed in HepG2 cells and primary hepatocytes. Surgery was associated with a decrease in the inflammatory response and revealed the role of mitogen-activated protein kinases. Nonalcoholic steatohepatitis was associated with an increased glutaminolysis-induced production of α-ketoglutarate and the hyperactivation of mammalian target of rapamycin complex 1. These changes were crucial for adenosine monophosphate-activated protein kinase/mammalian target of rapamycin-driven pathways that modulated hepatocyte survival by coordinating apoptosis and autophagy and affected methylation-related epigenomic remodelling enzymes. Hepatic transcriptome signatures and differentially methylated genomic regions distinguished patients with and without steatohepatitis. Our results suggest that the increased glutaminolysis-induced α-ketoglutarate production and the mammalian target of rapamycin complex 1 dysregulation play a crucial role in the inefficient adaptive responses leading to steatohepatitis in obesity.

Published
2022

27. More Adult Women than Men at High Cardiometabolic Risk Reported Worse Lifestyles and Self-Reported Health Status in the COVID-19 Lockdown

Author

Alejandro Oncina-Cánovas, Laura Compañ-Gabucio, Jesús Vioque, Miguel Ruiz-Canela, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Dora Romaguera, José López-Miranda, Ramón Estruch, Francisco J. Tinahones, José Lapetra, Jacqueline Álvarez-Pérez, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín-Sánchez, Virginia Esteve-Luque, Miguel Delgado-Rodríguez, María Ortiz-Ramos, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Cristina Razquin, Indira Paz-Graniel, Jose V. Sorlí, Olga Castañer, Antonio García-Rios, Laura Torres-Collado, Olga Fernández-Barceló, María Angeles Zulet, Elena Rayó-Gago, Rosa Casas, Naomi Cano-Ibáñez, Lucas Tojal-Sierra, Víctor J. Simón-Frapolli, Silvia Carlos, Sangeetha Shyam, Rebeca Fernández-Carrión, Albert Goday, Jose David Torres-Peña, Sandra González-Palacios, Sonia Eguaras, Nancy Babio, María Dolores Zomeño, and Manuela García-de-la-Hera

Subjects
COVID-19, metabolic syndrome, self-reported health, Mediterranean diet, lifestyle, Nutrition. Foods and food supply, TX341-641
Abstract

Background: The COVID-19 lockdown represented an immense impact on human health, which was characterized by lifestyle and dietary changes, social distancing and isolation at home. Some evidence suggests that these consequences mainly affected women and altered relevant ongoing clinical trials. The aim of this study was to evaluate the status and changes in diet, physical activity (PA), sleep and self-reported health status (SRH) as perceived by older adult men and women with metabolic syndrome during the COVID-19 lockdown. Methods: We analyzed data from 4681 Spanish adults with metabolic syndrome. We carried out a telephone survey during May and June 2020 to collect information on demographics, dietary habits, PA, sleep, SRH and anthropometric data. Results: The mean age of participants was 64.9 years at recruitment, and 52% of participants were men. Most participants (64.1%) perceived a decrease in their PA during confinement. Regarding gender-specific differences, a higher proportion of women than men perceived a decrease in their PA (67.5% vs. 61.1%), Mediterranean diet adherence (20.9% vs. 16.8%), sleep hours (30.3% vs. 19.1%), sleep quality (31.6% vs. 18.2%) and SRH (25.9% vs. 11.9%) (all p < 0.001). Conclusions: The COVID-19 lockdown affected women more negatively, particularly their self-reported diet, PA, sleep and health status.

Published
2024
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30. Reduction of circulating methylglyoxal levels by a Mediterranean diet is associated with preserved kidney function in patients with type 2 diabetes and coronary heart disease: From the CORDIOPREV randomized controlled trial

Author

Gutierrez-Mariscal, Francisco M., Podadera-Herreros, Alicia, Alcalá-Diaz, Juan F., Cardelo, Magdalena P., Arenas-de Larriva, Antonio P., Cruz-Ares, Silvia de la, Torres-Peña, Jose D., Luque, Raul M., Perez-Martinez, Pablo, Delgado-Lista, Javier, Lopez-Miranda, Jose, and Yubero-Serrano, Elena M.

Published
2024
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31. Dietary antioxidant intake reduces carotid intima-media thickness in coronary heart disease patients: From the CORDIOPREV study

Author

Rivas-Garcia, Lorenzo, Quintana-Navarro, Gracia M., Torres-Peña, Jose D., Arenas-de Larriva, Antonio P., Alcala-Díaz, Juan F., Yubero-Serrano, Elena M., Perez Caballero, Ana I., Ortiz-Morales, Ana M., Rangel-Zuñiga, Oriol Alberto, López-Moreno, Alejandro, Ordovas, Jose M., Perez-Martinez, Pablo, Lopez-Miranda, Jose, and Delgado-Lista, Javier

Published
2024
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32. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial

Author

Naomi Cano-Ibáñez, Lluis Serra-Majem, Sandra Martín-Peláez, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Camille Lassale, Jose Alfredo Martínez, Ángel M Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Ana María Gómez-Pérez, José Lapetra, Fernando Fernández-Aranda, Aurora Bueno-Cavanillas, Josep A Tur, Naiara Cubelos, Xavier Pintó, José Juan Gaforio, Pilar Matía-Martín, Josep Vidal, Cristina Calderón, Lidia Daimiel, Emilio Ros, Alfredo Gea, Nancy Babio, Ignacio Manuel Gimenez-Alba, María Dolores Zomeño-Fajardo, Itziar Abete, Lucas Tojal Sierra, Rita P Romero-Galisteo, Manoli García de la Hera, Marian Martín-Padillo, Antonio García-Ríos, Rosa M Casas, JC Fernández-García, José Manuel Santos-Lozano, Estefanía Toledo, Nerea Becerra-Tomas, Jose V Sorli, Helmut Schröder, María A Zulet, Carolina Sorto-Sánchez, Javier Diez-Espino, Carlos Gómez-Martínez, Montse Fitó, and Almudena Sánchez-Villegas

Subjects
Dietary diversity score, Depression, PREDIMED-Plus study, Public aspects of medicine, RA1-1270, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Objective: To examine the cross-sectional and longitudinal (2-year follow-up) associations between dietary diversity (DD) and depressive symptoms. Design: An energy-adjusted dietary diversity score (DDS) was assessed using a validated FFQ and was categorised into quartiles (Q). The variety in each food group was classified into four categories of diversity (C). Depressive symptoms were assessed with Beck Depression Inventory-II (Beck II) questionnaire and depression cases defined as physician-diagnosed or Beck II >= 18. Linear and logistic regression models were used. Setting: Spanish older adults with metabolic syndrome (MetS). Participants: A total of 6625 adults aged 55–75 years from the PREDIMED-Plus study with overweight or obesity and MetS. Results: Total DDS was inversely and statistically significantly associated with depression in the cross-sectional analysis conducted; OR Q4 v. Q1 = 0·76 (95 % CI (0·64, 0·90)). This was driven by high diversity compared to low diversity (C3 v. C1) of vegetables (OR = 0·75, 95 % CI (0·57, 0·93)), cereals (OR = 0·72 (95 % CI (0·56, 0·94)) and proteins (OR = 0·27, 95 % CI (0·11, 0·62)). In the longitudinal analysis, there was no significant association between the baseline DDS and changes in depressive symptoms after 2 years of follow-up, except for DD in vegetables C4 v. C1 = (β = 0·70, 95 % CI (0·05, 1·35)). Conclusions: According to our results, DD is inversely associated with depressive symptoms, but eating more diverse does not seem to reduce the risk of future depression. Additional longitudinal studies (with longer follow-up) are needed to confirm these findings.

Published
2023
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33. Ultra-processed foods consumption as a promoting factor of greenhouse gas emissions, water, energy, and land use: A longitudinal assessment

Author

García, Silvia, Pastor, Rosario, Monserrat-Mesquida, Margalida, Álvarez-Álvarez, Laura, Rubín-García, María, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Martínez, J. Alfredo, Tojal-Sierra, Lucas, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José Manuel, Serra-Majem, Lluís, Cano-Ibañez, Naomi, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Buil-Cosiales, Pilar, Martínez-Rodríguez, María Ángeles, Coltell, Oscar, Castañer, Olga, Garcia-Rios, Antonio, Barceló, Concepción, Gómez-Gracia, Enrique, Zulet, Maria Ángeles, Konieczna, Jadwiga, Casas, Rosa, Massó-Guijarro, Paloma, Goicolea-Güemez, Leire, Bernal-López, María Rosa, Bes-Rastrollo, Maira, Shyam, Sangeetha, González, José I., Zomeño, María Dolores, Peña-Orihuela, Patricia J., González-Palacios, Sandra, Toledo, Estefanía, Khoury, Nadine, Perez, Karla Alejandra, Martín-Sánchez, Vicente, Tur, Josep A., and Bouzas, Cristina

Published
2023
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35. Cisplatin cycles treatment sustains cardiovascular and renal damage involving TLR4 and NLRP3 pathways

Author

Antonio González, Soledad García‐Gómez‐Heras, Raquel Franco‐Rodríguez, Visitación López‐Miranda, and Esperanza Herradón

Subjects
cardiovascular toxicity, cisplatin cycles, NLRP3, renal damage, TLR4, Therapeutics. Pharmacology, RM1-950
Abstract

Abstract Cisplatin is clinically proven to combat different cancers, including sarcomas, soft tissue cancers, bones, muscles, and blood. However, renal and cardiovascular toxicities are important limitations in cisplatin therapeutical use. Immunoinflammation could be key factor in cisplatin‐induced toxicity. The aim of the present study was to evaluate the activation of the inflammatory TLR4/NLRP3 pathway as a common mechanism for cardiovascular and renal cisplatin's cycles treatment toxicity. Adult male Wistar rats were treated with saline, cisplatin 2 mg/kg or cisplatin 3 mg/kg (intraperitoneally once a week, for five experimental weeks). After treatments, plasma, cardiac, vascular, and renal tissues were collected. Plasma malondialdehyde (MDA) and inflammatory cytokines were determined. TLR4, MyD88, NF‐κβ p65, NLRP3, and procaspase‐1 tissue expressions were also analyzed. Cisplatin treatment induced a dose‐dependent increase in plasma MDA and IL‐18. In cardiovascular system, an increase in NLRP3 and in cleaved caspase‐1 were observed in cardiac tissue and a moderate increase in TLR4, MyD88 appeared in mesenteric artery. In kidney, a significant dose‐dependent increase in TLR4, MyD88 and NLRP3 and cleaved caspase 1 expressions were observed after cisplatin treatments. In conclusion, cisplatin cycles provoke a low grade pro‐inflammatory systemic state. Kidney was more sensitive than cardiovascular tissues to this pro‐inflammatory state. TLR4 and NLRP3 are key pathways involved in renal tissue damage, NLRP3 is the main pathway involved in cardiac toxicity and TLR4 pathway in resistance vessel toxicity.

Published
2023
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36. Increased ultra-processed food consumption is associated with worsening of cardiometabolic risk factors in adults with metabolic syndrome: Longitudinal analysis from a randomized trial

Author

González-Palacios, Sandra, Oncina-Cánovas, Alejandro, García-de-la-Hera, Manuela, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Luís, Cano-Ibañez, Naomi, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Bes-Rastrollo, Maira, Atzeni, Alessandro, Sorli, Jose V., Zomeño, M. Dolors, Peña-Orihuela, Patricia J., Compañ-Gabucio, Laura M., Barón-López, Francisco J., Zulet, María Ángeles, Konieczna, Jadwiga, Casas, Rosa M., Garrido-Garrido, Eva M., Tojal-Sierra, Lucas, Gomez-Perez, Ana M., Ruiz-Canela, Miguel, Palau, Antoni, Saiz, Carmen, Pérez-Vega, Karla A., Garcia-Rios, Antonio, Torres-Collado, Laura, Basterra-Gortari, Javier, Garcidueñas-Fimbres, Tany E., Malcampo, Mireia, and Vioque, Jesús

Published
2023
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37. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.

Author

Khoury, Nadine, Martínez, María Ángeles, Paz-Graniel, Indira, Martínez-González, Miguel Ángel, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sanjurjo, Sergio Cinza, Pintó, Xavier, Gaforio, José Juan, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Sorlí, Jose V., Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Bellvert, Nuria Gómez, Gómez-Gracia, Enrique, Zulet, M.A., Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vázquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, and Salas-Salvadó, Jordi

Published
2023
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39. Assessing the dynamics of CO adsorption on Cu(110) using the vdW-DF2 functional and artificial neural networks.

Author

Gonzalez, Federico J., Seminara, Giulia N., López, Miranda I., Lombardi, Juan M., Ramos, Maximiliano, Tachino, Carmen A., Martínez, Alejandra E., and Busnengo, H. Fabio

Subjects
COPPER, INTERMOLECULAR forces, MOLECULAR beams, DENSITY functional theory, CARBON monoxide
Abstract

In this work, we revisit the dynamics of carbon monoxide molecular chemisorption on Cu(110) by using quasi-classical trajectory calculations. The molecule–surface interaction is described through an atomistic neural network approach based on Density Functional Theory calculations using a nonlocal exchange–correlation (XC) functional that includes the effect of long-range dispersion forces: vdW-DF2 [Lee et al. Phys. Rev. B, 82, 081101 (2010)]. With this approach, we significantly improve the agreement with experiments with respect to a similar previous study based on a semi-local XC functional. In particular, we obtain excellent agreement with molecular beam experimental data concerning the dependence of the initial sticking probability on surface temperature and impact energy at normal incidence. For off-normal incidence, our results also reproduce two trends observed experimentally: (i) the preferential sticking for molecules impinging parallel to the [ 1 ̄ 10] direction compared to [001] and (ii) the change from positive to negative scaling as the impact energy increases. Nevertheless, understanding the origin of some remaining quantitative discrepancies with experiments requires further investigations. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Pembrolizumab in combination with gemcitabine for patients with HER2-negative advanced breast cancer: GEICAM/2015–04 (PANGEA-Breast) study

Author

L. de la Cruz-Merino, M. Gion, J. Cruz, JL. Alonso-Romero, V. Quiroga, F. Moreno, R. Andrés, M. Santisteban, M. Ramos, E. Holgado, J. Cortés, E. López-Miranda, A. Cortés, F. Henao, N. Palazón-Carrión, L. M. Rodriguez, I. Ceballos, A. Soto, A. Puertes, M. Casas, S. Benito, M. Chiesa, S. Bezares, R. Caballero, C. Jiménez-Cortegana, V. Sánchez-Margalet, and F. Rojo

Subjects
Pembrolizumab, Chemotherapy, HER2-negative, Advanced breast cancer, TILs, PD-L1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background We evaluated a new chemoimmunotherapy combination based on the anti-PD1 monoclonal antibody pembrolizumab and the pyrimidine antimetabolite gemcitabine in HER2- advanced breast cancer (ABC) patients previously treated in the advanced setting, in order to explore a potential synergism that could eventually obtain long term benefit in these patients. Methods HER2-negative ABC patients received 21-day cycles of pembrolizumab 200 mg (day 1) and gemcitabine (days 1 and 8). A run-in-phase (6 + 6 design) was planned with two dose levels (DL) of gemcitabine (1,250 mg/m2 [DL0]; 1,000 mg/m2 [DL1]) to determine the recommended phase II dose (RP2D). The primary objective was objective response rate (ORR). Tumor infiltrating lymphocytes (TILs) density and PD-L1 expression in tumors and myeloid-derived suppressor cells (MDSCs) levels in peripheral blood were analyzed. Results Fourteen patients were treated with DL0, resulting in RP2D. Thirty-six patients were evaluated during the first stage of Simon’s design. Recruitment was stopped as statistical assumptions were not met. The median age was 52; 21 (58%) patients had triple-negative disease, 28 (78%) visceral involvement, and 27 (75%) ≥ 2 metastatic locations. Progression disease was observed in 29 patients. ORR was 15% (95% CI, 5–32). Eight patients were treated ≥ 6 months before progression. Fourteen patients reported grade ≥ 3 treatment-related adverse events. Due to the small sample size, we did not find any clear association between immune tumor biomarkers and treatment efficacy that could identify a subgroup with higher probability of response or better survival. However, patients that experienced a clinical benefit showed decreased MDSCs levels in peripheral blood along the treatment. Conclusion Pembrolizumab 200 mg and gemcitabine 1,250 mg/m2 were considered as RP2D. The objective of ORR was not met; however, 22% patients were on treatment for ≥ 6 months. ABC patients that could benefit of chemoimmunotherapy strategies must be carefully selected by robust and validated biomarkers. In our heavily pretreated population, TILs, PD-L1 expression and MDSCs levels could not identify a subgroup of patients for whom the combination of gemcitabine and pembrolizumab would induce long term benefit. Trial registration ClinicalTrials.gov and EudraCT (NCT03025880 and 2016–001,779-54, respectively). Registration dates: 20/01/2017 and 18/11/2016, respectively.

Published
2022
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41. Evaluation of pectin extractions and their application in the alkaline Maillard reaction

Author

María-Guadalupe Guízar-Amezcua, Alvaro Pineda-Santana, Martha-Isabel González-Domínguez, Leonardo-Ramses Cajero-Zul, Luis-Guillermo Guerrero-Ramírez, Armando López-Miranda, Apolo Nambo, and Janneth López-Mercado

Subjects
Medicine, Science
Abstract

Abstract A 23 factorial design was used to evaluate the influence of temperature, catalyst and time and esterification degree (DE) of pectin obtained from mango, orange and tangerine peels as well as tamarind seeds by using the acid hydrolysis method. The study showed that a high temperature positively influenced the percentage of pectin yield for the four second generation biomasses. Nevertheless, the temperature showed a greater influence in the solubility and diffusion of the acid solvent in the tamarind seed matrix, resulting a pectin recovery 32.9%. Concerning the %DE, the most statistically significant value observed was dependent on the type of biomass studied. The %DE and the nature of the pectin are determining factors in the pectin’s final use, in the present work the pectin extracted was used to produce furfural, a precursor of high value chemicals. The furfural production was achieved through alkaline hydrolysis and enhanced using the Maillard reaction, reaching a maximum concentration of 71.8 g/L which represents a 42.1% increase from the alkaline hydrolysis.

Published
2022
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43. One-year changes in fruit and vegetable variety intake and cardiometabolic risk factors changes in a middle-aged Mediterranean population at high cardiovascular risk

Author

López-González, Leyre, Becerra-Tomás, Nerea, Babio, Nancy, Martínez-González, Miguel Ángel, Nishi, Stephanie K., Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramon, Bernal-López, M. Rosa, Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Vázquez-Ruiz, Zenaida, Martín-Luján, Francisco M., Sorlí, José V., Castañer, Olga, Zulet, M. Angeles, Tojal-Sierra, Lucas, Carabaño-Moral, Rosa, Román-Maciá, Josefa, Rayó, Elena, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana M., Santos-Lozano, José M., Buil-Cosiales, Pilar, Asensio, Eva M., Lassale, Camille, Abete, Itziar, Salaverria-Lete, Itziar, Sayón-Orea, Carmen, Schröder, Helmut, and Salas-Salvadó, Jordi

Published
2022
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44. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Author

Valle-Hita, Cristina, Díaz-López, Andrés, Becerra-Tomás, Nerea, Martínez-González, Miguel A., García, Verónica Ruiz, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Cano-Ibáñez, Naomi, Tur, Josep A., Rubín-García, María, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Fontao, Sebastian Mas, Daimiel, Lidia, Ros, Emilio, Toledo, Estefania, Sorlí, José V., Roca, C., Abete, Iztiar, Moreno-Rodriguez, Anai, Crespo-Oliva, Edelys, Candela-García, Inmaculada, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Fernandez-Garcia, Jose Carlos, Santos-Lozano, José Manuel, Diez-Espino, Javier, Ortega-Azorín, Carolina, Comas, M., Zulet, M. Angeles, Sorto-Sanchez, Carolina, Ruiz-Canela, Miguel, Fitó, Montse, Salas-Salvadó, Jordi, and Babio, Nancy

Published
2022
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46. Association between telomere length and intima-media thickness of both common carotid arteries in patients with coronary heart disease: From the CORDIOPREV randomized controlled trial

Author

Ojeda-Rodriguez, Ana, Alcala-Diaz, Juan F., Rangel-Zuñiga, Oriol Alberto, Arenas-de Larriva, Antonio Pablo, Gutierrez-Mariscal, Francisco M., Gómez-Luna, Purificación, Torres-Peña, Jose D., Garcia-Rios, Antonio, Romero-Cabrera, Juan L., Malagon, Maria M., Perez-Martinez, Pablo, Ordovas, Jose M., Delgado-Lista, Javier, Yubero-Serrano, Elena M., and Lopez-Miranda, Jose

Published
2023
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47. Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study

Author

Ni, Jiaqi, Nishi, Stephanie K., Babio, Nancy, Ros, Emili, Basterra-Gortari, F Javier, Corella, Dolores, O, Castañer, Martínez, J Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José Manuel, Serra-Majem, J Lluís, Cano-Ibáñez, Naomi, Tur, Josep A., Fernández-García, José Manuel, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández-Aranda, Fernando, Ruiz-Canela, Miguel, Mestres Solà, Cristina, Portolés, Olga, Sala-Vila, Aleix, Garcia-Rios, Antonio, Compañ-Gabucio, Laura María, Gómez-Gracia, Enrique, Zulet, M Angeles, Chaplin, Alice, Casas, Rosa, Martínez-Diz, Silvia, Tojal-Sierra, Lucas, Gómez-Pérez, Ana María, Toledo, Estefanía, Rios, Santiago, Ortega-Azorín, Carolina, de la Torre, Rafael, Peña-Orihuela, Patricia J., Garcia-de la Hera, Manuela, Sayón-Orea, Carmen, Malcampo, Mireia, and Salas-Salvadó, Jordi

Published
2023
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49. A single-arm study design with non-inferiority and superiority time-to-event endpoints: a tool for proof-of-concept and de-intensification strategies in breast cancer

Author

Miguel Sampayo-Cordero, Bernat Miguel-Huguet, Andrea Malfettone, Elena López-Miranda, María Gion, Elena Abad, Daniel Alcalá-López, Jhudit Pérez-Escuredo, José Manuel Pérez-García, Antonio Llombart-Cussac, and Javier Cortés

Subjects
time-to-event, non-inferiority, single-arm, phase II, clinical trial, superiority, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

De-escalation trials in oncology evaluate therapies that aim to improve the quality of life of patients with low-risk cancer by avoiding overtreatment. Non-inferiority randomized trials are commonly used to investigate de-intensified regimens with similar efficacy to that of standard regimens but with fewer adverse effects (ESMO evidence tier A). In cases where it is not feasible to recruit the number of patients needed for a randomized trial, single-arm prospective studies with a hypothesis of non-inferiority can be conducted as an alternative. Single-arm studies are also commonly used to evaluate novel treatment strategies (ESMO evidence tier B). A single-arm design that includes both non-inferiority and superiority primary objectives will enable the ranking of clinical activity and other parameters such as safety, pharmacokinetics, and pharmacodynamics data. Here, we describe the statistical principles and procedures to support such a strategy. The non-inferiority margin is calculated using the fixed margin method. Sample size and statistical analyses are based on the maximum likelihood method for exponential distributions. We present example analyses in metastatic and adjuvant settings to illustrate the usefulness of our methodology. We also explain its implementation with nonparametric methods. Single-arm designs with non-inferiority and superiority analyses are optimal for proof-of-concept and de-escalation studies in oncology.

Published
2023
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50. Maintained complete response to talazoparib in a BRCA-2 mutated metastatic luminal breast cancer: case report and review of literature

Author

Víctor Albarrán, Jesús Chamorro, Javier Pozas, María San Román, Diana Isabel Rosero, Cristina Saavedra, María Gion, Alfonso Cortés, Elena Escalera, Eva Guerra, Elena López Miranda, María Fernández Abad, and Noelia Martínez Jañez

Subjects
breast cancer, BRCA, germline, PARP inhibitors, olaparib, talazoparib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

PARP inhibitors are progressively becoming a part of our therapeutic arsenal against BRCA-defective tumors, because of their capacity to induce synthetic lethality in cells with a deficiency in the homologous recombination repair system. Olaparib and talazoparib have been approved for metastatic breast cancer in carriers of germline BRCA mutations, which are found in approximately 6% of patients with breast cancer. We report the case of a patient with metastatic breast cancer, carrier of a germline mutation in BRCA2, with a complete response to first-line treatment with talazoparib, maintained after 6 years. To the best of our knowledge, this is the longest response reported with a PARP inhibitor in a BRCA-mutated tumor. We have made a review of literature, regarding the rationale for PARP inhibitors in carriers of BRCA mutations and their clinical relevance in the management of advanced breast cancer, as well as their emerging role in early stage disease, alone and in combination with other systemic therapies.

Published
2023
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