1. Preclinical efficacy and safety of herbal formulation for management of wounds
- Author
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Ogwang, PE, Nyafuono, J, Agwaya, Moses, Omujal, F, Tumusiime, HR, and Kyakulaga, AH
- Abstract
Background: Medicinal plants in Uganda and other developing countries have been scientifically demonstrated to have medicinal benefits but few or none have been translated to products for clinical use. Most herbal products developed by local herbalists and sold to the public are not standardized and lack efficacy and safety data to support use. Objective: To formulate from two Ugandan medicinal plants a herbal product for wound management and test its preclinical safety and efficacy using rat models. Methods: Thirty (30) Wistar albino rats were randomly divided into three groups and wounds were surgically created on the mid-dorsal region. The wounds were treated topically with distilled water (group I), Jena® (group II) and Neomycin sulfate cream (group III). The effects of the treatments on rate of wound closure, epithelialisation time and histological organization of tissue were assessed. Results: The herbal formulation (Jena) had a significantly higher rate of wound closure than neomycin (p
- Published
- 2012