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Exosomal formulation of anthocyanidins against multiple cancer types.
- Source :
-
Cancer letters [Cancer Lett] 2017 May 01; Vol. 393, pp. 94-102. Date of Electronic Publication: 2017 Feb 12. - Publication Year :
- 2017
-
Abstract
- Over the last two decades, berries and berry bioactives, particularly anthocyanins and their aglycones anthocyanidins (Anthos) have demonstrated excellent anti-oxidant, anti-proliferative, apoptotic and anti-inflammatory properties. However, their physicochemical and pharmacokinetic limitations such as, low permeability, and poor oral bioavailability are considered as unfavorable properties for development as drugs. Therefore there is a need to develop systems for efficient systemic delivery and robust bioavailability. In this study we prepared nano-formulation of bilberry-derived Anthos using exosomes harvested from raw bovine milk. Exosomal formulation of Anthos enhanced antiproliferative and anti-inflammatory effects compared with the free Anthos against various cancer cells in vitro. Our data also showed significantly enhanced therapeutic response of exosomal-Anthos formulation compared with the free Anthos against lung cancer tumor xenograft in nude mice. The Anthos showed no signs of gross or systemic toxicity in wild-type mice. Thus, exosomes provide an effective alternative for oral delivery of Anthos that is efficacious, cost-effective, and safe, and this regimen can be developed as a non-toxic, widely applicable therapeutic agent.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- A549 Cells
Administration, Oral
Animals
Anthocyanins chemistry
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents chemistry
Antineoplastic Agents, Phytogenic administration & dosage
Antineoplastic Agents, Phytogenic chemistry
Cell Proliferation drug effects
Dose-Response Relationship, Drug
Drug Compounding
Female
HCT116 Cells
Humans
MCF-7 Cells
Male
Mice, Nude
Milk toxicity
Nanoparticles
Time Factors
Tumor Burden drug effects
Xenograft Model Antitumor Assays
Anthocyanins pharmacology
Anti-Inflammatory Agents pharmacology
Antineoplastic Agents, Phytogenic pharmacology
Drug Carriers
Exosomes chemistry
Milk chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 393
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 28202351
- Full Text :
- https://doi.org/10.1016/j.canlet.2017.02.004