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2. Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Author

Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Díez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Jane C., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, FitzGerald, Liesel M., Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna H., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, and Zheng, Wei

Published
2024
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3. Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea

Author

Nabila, Salma, Choi, Ji-Yeob, Abe, Sarah Krull, Islam, Md Rashedul, Rahman, Md Shafiur, Saito, Eiko, Shin, Aesun, Merritt, Melissa A., Katagiri, Ryoko, Shu, Xiao-Ou, Sawada, Norie, Tamakoshi, Akiko, Sakata, Ritsu, Hozawa, Atsushi, Kim, Jeongseon, Nagata, Chisato, Park, Sue K., Kweon, Sun-Seog, Cai, Hui, Tsugane, Shoichiro, Kimura, Takashi, Kanemura, Seiki, Sugawara, Yumi, Wada, Keiko, Shin, Min-Ho, Ahsan, Habibul, Boffetta, Paolo, Chia, Kee Seng, Matsuo, Keitaro, Qiao, You-Lin, Rothman, Nathaniel, Zheng, Wei, Inoue, Manami, and Kang, Daehee

Published
2024
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4. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J, Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M, Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A, Kim, Jin Hee, Albanes, Demetrius, Wong, Jason YY, Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E, Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H, Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, and Kweon, Sun-Seog

Subjects
Genetics, Cancer, Clinical Research, Human Genome, Prevention, Lung, Lung Cancer, Tobacco, Tobacco Smoke and Health, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Humans, Genome-Wide Association Study, Genetic Predisposition to Disease, Adenocarcinoma of Lung, Asia, Eastern, Lung Neoplasms, Polymorphism, Single Nucleotide
Abstract

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

Published
2023

5. Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Author

Thomas, Minta, Su, Yu-Ru, Rosenthal, Elisabeth A., Sakoda, Lori C., Schmit, Stephanie L., Timofeeva, Maria N., Chen, Zhishan, Fernandez-Rozadilla, Ceres, Law, Philip J., Murphy, Neil, Carreras-Torres, Robert, Diez-Obrero, Virginia, van Duijnhoven, Franzel J. B., Jiang, Shangqing, Shin, Aesun, Wolk, Alicja, Phipps, Amanda I., Burnett-Hartman, Andrea, Gsur, Andrea, Chan, Andrew T., Zauber, Ann G., Wu, Anna H., Lindblom, Annika, Um, Caroline Y., Tangen, Catherine M., Gignoux, Chris, Newton, Christina, Haiman, Christopher A., Qu, Conghui, Bishop, D. Timothy, Buchanan, Daniel D., Crosslin, David R., Conti, David V., Kim, Dong-Hyun, Hauser, Elizabeth, White, Emily, Siegel, Erin, Schumacher, Fredrick R., Rennert, Gad, Giles, Graham G., Hampel, Heather, Brenner, Hermann, Oze, Isao, Oh, Jae Hwan, Lee, Jeffrey K., Schneider, Jennifer L., Chang-Claude, Jenny, Kim, Jeongseon, Huyghe, Jeroen R., Zheng, Jiayin, Hampe, Jochen, Greenson, Joel, Hopper, John L., Palmer, Julie R., Visvanathan, Kala, Matsuo, Keitaro, Matsuda, Koichi, Jung, Keum Ji, Li, Li, Le Marchand, Loic, Vodickova, Ludmila, Bujanda, Luis, Gunter, Marc J., Matejcic, Marco, Jenkins, Mark A., Slattery, Martha L., D’Amato, Mauro, Wang, Meilin, Hoffmeister, Michael, Woods, Michael O., Kim, Michelle, Song, Mingyang, Iwasaki, Motoki, Du, Mulong, Udaltsova, Natalia, Sawada, Norie, Vodicka, Pavel, Campbell, Peter T., Newcomb, Polly A., Cai, Qiuyin, Pearlman, Rachel, Pai, Rish K., Schoen, Robert E., Steinfelder, Robert S., Haile, Robert W., Vandenputtelaar, Rosita, Prentice, Ross L., Küry, Sébastien, Castellví-Bel, Sergi, Tsugane, Shoichiro, Berndt, Sonja I., Lee, Soo Chin, Brezina, Stefanie, Weinstein, Stephanie J., Chanock, Stephen J., Jee, Sun Ha, Kweon, Sun-Seog, Vadaparampil, Susan, Harrison, Tabitha A., Yamaji, Taiki, Keku, Temitope O., Vymetalkova, Veronika, Arndt, Volker, Jia, Wei-Hua, Shu, Xiao-Ou, Lin, Yi, Ahn, Yoon-Ok, Stadler, Zsofia K., Van Guelpen, Bethany, Ulrich, Cornelia M., Platz, Elizabeth A., Potter, John D., Li, Christopher I., Meester, Reinier, Moreno, Victor, Figueiredo, Jane C., Casey, Graham, Lansdorp Vogelaar, Iris, Dunlop, Malcolm G., Gruber, Stephen B., Hayes, Richard B., Pharoah, Paul D. P., Houlston, Richard S., Jarvik, Gail P., Tomlinson, Ian P., Zheng, Wei, Corley, Douglas A., Peters, Ulrike, and Hsu, Li

Published
2023
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6. Lung Cancer Risk Prediction Models for Asian Ever-Smokers

Author

Yang, Jae Jeong, Wen, Wanqing, Zahed, Hana, Zheng, Wei, Lan, Qing, Abe, Sarah K., Rahman, Md. Shafiur, Islam, Md. Rashedul, Saito, Eiko, Gupta, Prakash C., Tamakoshi, Akiko, Koh, Woon-Puay, Gao, Yu-Tang, Sakata, Ritsu, Tsuji, Ichiro, Malekzadeh, Reza, Sugawara, Yumi, Kim, Jeongseon, Ito, Hidemi, Nagata, Chisato, You, San-Lin, Park, Sue K., Yuan, Jian-Min, Shin, Myung-Hee, Kweon, Sun-Seog, Yi, Sang-Wook, Pednekar, Mangesh S., Kimura, Takashi, Cai, Hui, Lu, Yukai, Etemadi, Arash, Kanemura, Seiki, Wada, Keiko, Chen, Chien-Jen, Shin, Aesun, Wang, Renwei, Ahn, Yoon-Ok, Shin, Min-Ho, Ohrr, Heechoul, Sheikh, Mahdi, Blechter, Batel, Ahsan, Habibul, Boffetta, Paolo, Chia, Kee Seng, Matsuo, Keitaro, Qiao, You-Lin, Rothman, Nathaniel, Inoue, Manami, Kang, Daehee, Robbins, Hilary A., and Shu, Xiao-Ou

Published
2024
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7. Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetes

Author

Bull, Caroline J., Hazelwood, Emma, Legge, Danny N., Corbin, Laura J., Richardson, Tom G., Lee, Matthew, Yarmolinsky, James, Smith-Byrne, Karl, Hughes, David A., Johansson, Mattias, Peters, Ulrike, Berndt, Sonja I., Brenner, Hermann, Burnett-Hartman, Andrea, Cheng, Iona, Kweon, Sun-Seog, Le Marchand, Loic, Li, Li, Newcomb, Polly A., Pearlman, Rachel, McConnachie, Alex, Welsh, Paul, Taylor, Roy, Lean, Mike E.J., Sattar, Naveed, Murphy, Neil, Gunter, Marc J., Timpson, Nicholas J., and Vincent, Emma E.

Published
2024
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8. Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Author

Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Potter, John, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, McDonnell, Kevin, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David, Joshi, Amit, Schafmayer, Clemens, Scacheri, Peter, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Haiman, Christopher, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Harris, Sarah, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Gruber, Stephen, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard, and Peters, Ulrike

Published
2023
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9. Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study

Author

Tsilidis, Konstantinos K, Papadimitriou, Nikos, Dimou, Niki, Gill, Dipender, Lewis, Sarah J, Martin, Richard M, Murphy, Neil, Markozannes, Georgios, Zuber, Verena, Cross, Amanda J, Burrows, Kimberley, Lopez, David S, Key, Timothy J, Travis, Ruth C, Perez-Cornago, Aurora, Hunter, David J, van Duijnhoven, Fränzel JB, Albanes, Demetrius, Arndt, Volker, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Boehm, Juergen, Brenner, Hermann, Burnett-Hartman, Andrea, Campbell, Peter T, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, de la Chapelle, Albert, Figueiredo, Jane C, Gallinger, Steven J, Giles, Graham G, Goodman, Phyllis J, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Hoffmeister, Michael, Jenkins, Mark A, Keku, Temitope O, Kweon, Sun-Seog, Larsson, Susanna C, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Martín, Vicente, Milne, Roger L, Moreno, Victor, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A, Offit, Kenneth, Pharoah, Paul DP, Platz, Elizabeth A, Potter, John D, Qi, Lihong, Rennert, Gad, Sakoda, Lori C, Schafmayer, Clemens, Slattery, Martha L, Snetselaar, Linda, Schenk, Jeanette, Thibodeau, Stephen N, Ulrich, Cornelia M, Van Guelpen, Bethany, Harlid, Sophia, Visvanathan, Kala, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Zheng, Wei, Bueno-de-Mesquita, Bas, Boutron-Ruault, Marie-Christine, Hughes, David J, Jakszyn, Paula, Kühn, Tilman, Palli, Domenico, Riboli, Elio, Giovannucci, Edward L, Banbury, Barbara L, Gruber, Stephen B, Peters, Ulrike, Gunter, Marc J, and on behalf of GECCO, CORECT

Subjects
Complementary and Integrative Health, Digestive Diseases, Clinical Research, Clinical Trials and Supportive Activities, Cancer, Colo-Rectal Cancer, Prevention, Nutrition, Prevention of disease and conditions, and promotion of well-being, 3.3 Nutrition and chemoprevention, Case-Control Studies, Colorectal Neoplasms, Dietary Supplements, Genetic Predisposition to Disease, Humans, Mendelian Randomization Analysis, Micronutrients, Risk Factors, Selenium, Vitamin B 12, White People, Mendelian randomization, genes, nutrition, supplements, colorectal cancer, Engineering, Medical and Health Sciences, Nutrition & Dietetics
Abstract

BackgroundThe literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.ObjectivesTo complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR).MethodsTwo-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.ResultsNominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentration and higher risk of colorectal cancer (ORSD: 1.12; 95% CI: 1.03, 1.21; P value = 0.01) and similarly for colon cancer. A nominally significant association was also noted for genetically predicted selenium concentration and lower risk of colon cancer (ORSD: 0.98; 95% CI: 0.96, 1.00; P value = 0.05) and similarly for distal colon cancer. These associations were robust to sensitivity analyses. Nominally significant inverse associations were observed for zinc and risk of colorectal and distal colon cancers, but sensitivity analyses could not be performed. None of these findings survived correction for multiple testing. Genetically predicted concentrations of β-carotene, calcium, copper, folate, magnesium, phosphorus, and vitamin B-6 were not associated with disease risk.ConclusionsThese results suggest possible causal associations of circulating iron and vitamin B-12 (positively) and selenium (inversely) with risk of colon cancer.

Published
2021

13. Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Author

Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Potter, John, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, McDonnell, Kevin, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David, Joshi, Amit, Schafmayer, Clemens, Scacheri, Peter, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Haiman, Christopher, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Harris, Sarah, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Gruber, Stephen, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard, and Peters, Ulrike

Published
2023
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14. Association of female reproductive and hormonal factors with gallbladder cancer risk in Asia: A pooled analysis of the Asia Cohort Consortium.

Author

Shin, Aesun, Cho, Sooyoung, Abe, Sarah Krull, Islam, Md Rashedul, Rahman, Md Shafiur, Saito, Eiko, Kazmi, Sayada Zartasha, Katagiri, Ryoko, Merritt, Melissa, Choi, Ji‐Yeob, Shu, Xiao‐Ou, Sawada, Norie, Tamakoshi, Akiko, Koh, Woon‐Puay, Sakata, Ritsu, Hozawa, Atsushi, Kim, Jeongseon, Park, Sue K., Kweon, Sun‐Seog, and Wen, Wanqing

Subjects
GALLBLADDER cancer, DISEASE risk factors, PROPORTIONAL hazards models, COHORT analysis, ASIANS
Abstract

The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone‐related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) to assess the association between reproductive factors (age at menarche, parity, age at first delivery, breastfeeding, and age at menopause) and GBC risk. We observed that a later age at menarche was associated with an increased risk of GBC (HR 1.4, 95% CI 1.16–1.70 for 17 years and older vs. 13–14 years), especially among the cohort born in 1940 and later (HR 2.5, 95% CI 1.50–4.35). Among the cohort born before 1940, women with a later age at first delivery showed an increased risk of GBC (HR 1.56, 95% CI 1.08–2.24 for 31 years of age and older vs. 20 years of age and younger). Other reproductive factors did not show a clear association with GBC risk. Later ages at menarche and at first delivery were associated with a higher risk of GBC, and these associations varied by birth cohort. [ABSTRACT FROM AUTHOR]

Published
2024
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15. A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator

Author

Lee, Matthew A, primary, Hatcher, Charlie A, additional, Hazelwood, Emma, additional, Goudswaard, Lucy J, additional, Tsilidis, Konstantinos K, additional, Vincent, Emma E, additional, Martin, Richard M, additional, Smith-Byrne, Karl, additional, Brenner, Hermann, additional, Cheng, Iona, additional, Kweon, Sun-Seog, additional, Le Marchand, Loic, additional, Newcomb, Polly A, additional, Schoen, Rovert E, additional, Peters, Ulrike, additional, Gunter, Marc J, additional, Van Guelpen, Bethany, additional, and Murphy, Neil, additional

Published
2024
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17. Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia cohort consortium.

Author

Yin, Xin, Kishida, Rie, Abe, Sarah Krull, Islam, Md. Rashedul, Rahman, Md. Shafiur, Saito, Eiko, Lan, Qing, Blechter, Batel, Merritt, Melissa, Choi, Ji‐Yeob, Shin, Aesun, Katagiri, Ryoko, Shu, Xiao‐Ou, Sawada, Norie, Tamakoshi, Akiko, Koh, Woon‐Puay, Tsuji, Ichiro, Nagata, Chisato, Park, Sue K., and Kweon, Sun‐Seog

Abstract

Previous studies have investigated the association between reproductive factors and lung cancer risk; however, findings have been inconsistent. In order to assess this association among Asian women, a total of 308,949 female participants from 11 prospective cohorts and four Asian countries (Japan, Korea, China, and Singapore) were included. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CIs). A total of 3,119 primary lung cancer cases and 2247 lung cancer deaths were identified with a mean follow‐up of 16.4 years. Parous women had a lower risk of lung cancer incidence and mortality as compared with nulliparous women, with HRs of 0.82 (95% CI = 0.70–0.96) and 0.78 (95% CI = 0.65–0.94). The protective association of parity and lung cancer incidence was greater among ever‐smokers (HR = 0.66, 95% CI = 0.49–0.87) than in never‐smokers (HR = 0.90, 95% CI = 0.74–1.09) (P‐interaction = 0.029). Compared with age at first delivery ≤20 years, older age at first delivery (21–25, ≥26 years) was associated with a lower risk of lung cancer incidence and mortality. Women who ever used hormone replacements had a higher likelihood of developing non‐small cell lung cancer (HR = 1.31, 95% CI = 1.02–1.68), compared to those who never used hormone replacements. Future studies are needed to assess the underlying mechanisms, the relationships within these female reproductive factors, and the potential changes in smoking habits over time. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Identifying metabolic features of colorectal cancer liability using Mendelian randomization

Author

Bull, Caroline, primary, Hazelwood, Emma, primary, Bell, Joshua A, additional, Tan, Vanessa, additional, Constantinescu, Andrei-Emil, additional, Borges, Carolina, additional, Legge, Danny, additional, Burrows, Kimberley, additional, Huyghe, Jeroen R, additional, Brenner, Hermann, additional, Castellvi-Bel, Sergi, additional, Chan, Andrew T, additional, Kweon, Sun-Seog, additional, Le Marchand, Loic, additional, Li, Li, additional, Cheng, Iona, additional, Pai, Rish K, additional, Figueiredo, Jane C, additional, Murphy, Neil, additional, Gunter, Marc J, additional, Timpson, Nicholas J, additional, and Vincent, Emma E, additional

Published
2023
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20. Author Response: Identifying metabolic features of colorectal cancer liability using Mendelian randomization

Author

Bull, Caroline, primary, Hazelwood, Emma, additional, Bell, Joshua A, additional, Tan, Vanessa, additional, Constantinescu, Andrei-Emil, additional, Borges, Carolina, additional, Legge, Danny, additional, Burrows, Kimberley, additional, Huyghe, Jeroen R, additional, Brenner, Hermann, additional, Castellvi-Bel, Sergi, additional, Chan, Andrew T, additional, Kweon, Sun-Seog, additional, Le Marchand, Loic, additional, Li, Li, additional, Cheng, Iona, additional, Pai, Rish K, additional, Figueiredo, Jane C, additional, Murphy, Neil, additional, Gunter, Marc J, additional, Timpson, Nicholas J, additional, and Vincent, Emma E, additional

Published
2023
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21. Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortiumc

Author

Oze, Isao, primary, Ito, Hidemi, additional, Koyanagi, Yuriko N., additional, Abe, Sarah Krull, additional, Rahman, Md. Shafiur, additional, Islam, Md. Rashedul, additional, Saito, Eiko, additional, Gupta, Prakash C., additional, Sawada, Norie, additional, Tamakoshi, Akiko, additional, Shu, Xiao‐Ou, additional, Sakata, Ritsu, additional, Malekzadeh, Reza, additional, Tsuji, Ichiro, additional, Kim, Jeongseon, additional, Nagata, Chisato, additional, You, San‐Lin, additional, Park, Sue K., additional, Yuan, Jian‐Min, additional, Shin, Myung‐Hee, additional, Kweon, Sun‐Seog, additional, Pednekar, Mangesh S., additional, Tsugane, Shoichiro, additional, Kimura, Takashi, additional, Gao, Yu‐Tang, additional, Cai, Hui, additional, Pourshams, Akram, additional, Lu, Yukai, additional, Kanemura, Seiki, additional, Wada, Keiko, additional, Sugawara, Yumi, additional, Chen, Chien‐Jen, additional, Chen, Yu, additional, Shin, Aesun, additional, Wang, Renwei, additional, Ahn, Yoon‐Ok, additional, Shin, Min‐Ho, additional, Ahsan, Habibul, additional, Boffetta, Paolo, additional, Chia, Kee Seng, additional, Qiao, You‐Lin, additional, Rothman, Nathaniel, additional, Zheng, Wei, additional, Inoue, Manami, additional, Kang, Daehee, additional, and Matsuo, Keitaro, additional

Published
2023
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23. Lung Cancer Risk Prediction Models for Asian Ever-Smokers

Author

Yang, Jae Jeong, primary, Wen, Wanqing, additional, Zahed, Hana, additional, Zheng, Wei, additional, Lan, Qing, additional, Abe, Sarah K., additional, Rahman, Md. Shafiur, additional, Islam, Md. Rashedul, additional, Saito, Eiko, additional, Gupta, Prakash C., additional, Tamakoshi, Akiko, additional, Koh, Woon-Puay, additional, Gao, Yu-Tang, additional, Sakata, Ritsu, additional, Tsuji, Ichiro, additional, Malekzadeh, Reza, additional, Sugawara, Yumi, additional, Kim, Jeongseon, additional, Ito, Hidemi, additional, Nagata, Chisato, additional, You, San-Lin, additional, Park, Sue K., additional, Yuan, Jian-Min, additional, Shin, Myung-Hee, additional, Kweon, Sun-Seog, additional, Yi, Sang-Wook, additional, Pednekar, Mangesh S., additional, Kimura, Takashi, additional, Cai, Hui, additional, Lu, Yukai, additional, Etemadi, Arash, additional, Kanemura, Seiki, additional, Wada, Keiko, additional, Chen, Chien-Jen, additional, Shin, Aesun, additional, Wang, Renwei, additional, Ahn, Yoon-Ok, additional, Shin, Min-Ho, additional, Ohrr, Heechoul, additional, Sheikh, Mahdi, additional, Blechter, Batel, additional, Ahsan, Habibul, additional, Boffetta, Paolo, additional, Chia, Kee Seng, additional, Matsuo, Keitaro, additional, Qiao, You-Lin, additional, Rothman, Nathaniel, additional, Inoue, Manami, additional, Kang, Daehee, additional, Robbins, Hilary A., additional, and Shu, Xiao-Ou, additional

Published
2023
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24. Identifying metabolic features of colorectal cancer liability using Mendelian randomization

Author

Bull, Caroline J., primary, Hazelwood, Emma, additional, Bell, Joshua A., additional, Tan, Vanessa Y., additional, Constantinescu, Andrei-Emil, additional, Borges, Maria Carolina, additional, Legge, Danny N., additional, Burrows, Kimberly, additional, Huyghe, Jeroen R., additional, Brenner, Hermann, additional, Castellví-Bel, Sergi, additional, Chan, Andrew T, additional, Kweon, Sun-Seog, additional, Marchand, Loic Le, additional, Li, Li, additional, Cheng, Iona, additional, Pai, Rish K., additional, Figueiredo, Jane C., additional, Murphy, Neil, additional, Gunter, Marc J., additional, Timpson, Nicholas J., additional, and Vincent, Emma E., additional

Published
2023
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25. Author Response: Identifying metabolic features of colorectal cancer liability using Mendelian randomization

Author

Bull, Caroline J., primary, Hazelwood, Emma, additional, Bell, Joshua A., additional, Tan, Vanessa Y., additional, Constantinescu, Andrei-Emil, additional, Borges, Maria Carolina, additional, Legge, Danny N., additional, Burrows, Kimberly, additional, Huyghe, Jeroen R., additional, Brenner, Hermann, additional, Castellví-Bel, Sergi, additional, Chan, Andrew T, additional, Kweon, Sun-Seog, additional, Marchand, Loic Le, additional, Li, Li, additional, Cheng, Iona, additional, Pai, Rish K., additional, Figueiredo, Jane C., additional, Murphy, Neil, additional, Gunter, Marc J., additional, Timpson, Nicholas J., additional, and Vincent, Emma E., additional

Published
2023
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29. Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer

Author

Lu, Yingchang, Kweon, Sun-Seog, Tanikawa, Chizu, Jia, Wei-Hua, Xiang, Yong-Bing, Cai, Qiuyin, Zeng, Chenjie, Schmit, Stephanie L., Shin, Aesun, Matsuo, Keitaro, Jee, Sun Ha, Kim, Dong-Hyun, Kim, Jeongseon, Wen, Wanqing, Shi, Jiajun, Guo, Xingyi, Li, Bingshan, Wang, Nan, Zhang, Ben, Li, Xinxiang, Shin, Min-Ho, Li, Hong-Lan, Ren, Zefang, Oh, Jae Hwan, Oze, Isao, Ahn, Yoon-Ok, Jung, Keum Ji, Conti, David V., Schumacher, Fredrick R., Rennert, Gad, Jenkins, Mark A., Campbell, Peter T., Hoffmeister, Michael, Casey, Graham, Gruber, Stephen B., Gao, Jing, Gao, Yu-Tang, Pan, Zhi-Zhong, Kamatani, Yoichiro, Zeng, Yi-Xin, Shu, Xiao-Ou, Long, Jirong, Matsuda, Koichi, and Zheng, Wei

Published
2019
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31. Reproductive Factors and Endometrial Cancer Risk Among Women

Author

Katagiri, Ryoko, primary, Iwasaki, Motoki, additional, Abe, Sarah Krull, additional, Islam, Md. Rashedul, additional, Rahman, Md. Shafiur, additional, Saito, Eiko, additional, Merritt, Melissa A., additional, Choi, Ji-Yeob, additional, Shin, Aesun, additional, Sawada, Norie, additional, Tamakoshi, Akiko, additional, Koh, Woon-Puay, additional, Sakata, Ritsu, additional, Tsuji, Ichiro, additional, Kim, Jeongseon, additional, Nagata, Chisato, additional, Park, Sue K., additional, Kweon, Sun-Seog, additional, Shu, Xiao-Ou, additional, Gao, Yu-Tang, additional, Tsugane, Shoichiro, additional, Kimura, Takashi, additional, Yuan, Jian-Min, additional, Kanemura, Seiki, additional, Lu, Yukai, additional, Sugawara, Yumi, additional, Wada, Keiko, additional, Shin, Min-Ho, additional, Ahsan, Habibul, additional, Boffetta, Paolo, additional, Chia, Kee Seng, additional, Matsuo, Keitaro, additional, Qiao, You-Lin, additional, Rothman, Nathaniel, additional, Zheng, Wei, additional, Inoue, Manami, additional, and Kang, Daehee, additional

Published
2023
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35. Discovery of common and rare genetic risk variants for colorectal cancer

Author

Huyghe, Jeroen R., Bien, Stephanie A., Harrison, Tabitha A., Kang, Hyun Min, Chen, Sai, Schmit, Stephanie L., Conti, David V., Qu, Conghui, Jeon, Jihyoun, Edlund, Christopher K., Greenside, Peyton, Wainberg, Michael, Schumacher, Fredrick R., Smith, Joshua D., Levine, David M., Nelson, Sarah C., Sinnott-Armstrong, Nasa A., Albanes, Demetrius, Alonso, M. Henar, Anderson, Kristin, Arnau-Collell, Coral, Arndt, Volker, Bamia, Christina, Banbury, Barbara L., Baron, John A., Berndt, Sonja I., Bézieau, Stéphane, Bishop, D. Timothy, Boehm, Juergen, Boeing, Heiner, Brenner, Hermann, Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D., Burnett-Hartman, Andrea, Butterbach, Katja, Caan, Bette J., Campbell, Peter T., Carlson, Christopher S., Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chirlaque, Maria-Dolores, Cho, Sang Hee, Connolly, Charles M., Cross, Amanda J., Cuk, Katarina, Curtis, Keith R., de la Chapelle, Albert, Doheny, Kimberly F., Duggan, David, Easton, Douglas F., Elias, Sjoerd G., Elliott, Faye, English, Dallas R., Feskens, Edith J. M., Figueiredo, Jane C., Fischer, Rocky, FitzGerald, Liesel M., Forman, David, Gala, Manish, Gallinger, Steven, Gauderman, W. James, Giles, Graham G., Gillanders, Elizabeth, Gong, Jian, Goodman, Phyllis J., Grady, William M., Grove, John S., Gsur, Andrea, Gunter, Marc J., Haile, Robert W., Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Hayes, Richard B., Hofer, Philipp, Hoffmeister, Michael, Hopper, John L., Hsu, Wan-Ling, Huang, Wen-Yi, Hudson, Thomas J., Hunter, David J., Ibañez-Sanz, Gemma, Idos, Gregory E., Ingersoll, Roxann, Jackson, Rebecca D., Jacobs, Eric J., Jenkins, Mark A., Joshi, Amit D., Joshu, Corinne E., Keku, Temitope O., Key, Timothy J., Kim, Hyeong Rok, Kobayashi, Emiko, Kolonel, Laurence N., Kooperberg, Charles, Kühn, Tilman, Küry, Sébastien, Kweon, Sun-Seog, Larsson, Susanna C., Laurie, Cecelia A., Le Marchand, Loic, Leal, Suzanne M., Lee, Soo Chin, Lejbkowicz, Flavio, Lemire, Mathieu, Li, Christopher I., Li, Li, Lieb, Wolfgang, Lin, Yi, Lindblom, Annika, Lindor, Noralane M., Ling, Hua, Louie, Tin L., Männistö, Satu, Markowitz, Sanford D., Martín, Vicente, Masala, Giovanna, McNeil, Caroline E., Melas, Marilena, Milne, Roger L., Moreno, Lorena, Murphy, Neil, Myte, Robin, Naccarati, Alessio, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Onland-Moret, N. Charlotte, Pardini, Barbara, Parfrey, Patrick S., Pearlman, Rachel, Perduca, Vittorio, Pharoah, Paul D. P., Pinchev, Mila, Platz, Elizabeth A., Prentice, Ross L., Pugh, Elizabeth, Raskin, Leon, Rennert, Gad, Rennert, Hedy S., Riboli, Elio, Rodríguez-Barranco, Miguel, Romm, Jane, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Seminara, Daniela, Shah, Mitul, Shelford, Tameka, Shin, Min-Ho, Shulman, Katerina, Sieri, Sabina, Slattery, Martha L., Southey, Melissa C., Stadler, Zsofia K., Stegmaier, Christa, Su, Yu-Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Thomas, Sushma S., Toland, Amanda E., Trichopoulou, Antonia, Ulrich, Cornelia M., Van Den Berg, David J., van Duijnhoven, Franzel J. B., Van Guelpen, Bethany, van Kranen, Henk, Vijai, Joseph, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Win, Aung Ko, Wolf, C. Roland, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zaidi, Syed H., Zanke, Brent W., Zhang, Qing, Zheng, Wei, Scacheri, Peter C., Potter, John D., Bassik, Michael C., Kundaje, Anshul, Casey, Graham, Moreno, Victor, Abecasis, Goncalo R., Nickerson, Deborah A., Gruber, Stephen B., Hsu, Li, and Peters, Ulrike

Published
2019
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37. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

Author

Bull, Caroline J., Bell, Joshua A., Murphy, Neil, Sanderson, Eleanor, Davey Smith, George, Timpson, Nicholas J., Banbury, Barbara L., Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Burnett-Hartman, Andrea, Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Cross, Amanda J., de la Chapelle, Albert, Figueiredo, Jane C., Gallinger, Steven J., Gapstur, Susan M., Giles, Graham G., Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Joshu, Corinne E., Keku, Temitope O., Kühn, Tilman, Kweon, Sun-Seog, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Martín, Vicente, May, Anne M., Milne, Roger L., Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Qu, Conghui, Quirós, J. Ramón, Rennert, Gad, Riboli, Elio, Sakoda, Lori C., Schafmayer, Clemens, Schoen, Robert E., Slattery, Martha L., Tangen, Catherine M., Tsilidis, Kostas K., Ulrich, Cornelia M., van Duijnhoven, Fränzel J. B., van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Wang, Hansong, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Campbell, Peter T., Zheng, Wei, Peters, Ulrike, Vincent, Emma E., and Gunter, Marc J.

Published
2020
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38. Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participants

Author

Lu, Yao, primary, Kiechl, Sophia J., additional, Wang, Jie, additional, Xu, Qingbo, additional, Kiechl, Stefan, additional, Pechlaner, Raimund, additional, Aguilar, David, additional, Al-Hashmi, Khamis M., additional, Alvim, Rafael O., additional, Al-Zakwani, Ibrahim S., additional, Antza, Christina, additional, Cicero, Arrigo F.G., additional, Avramovska, Maja, additional, Avramovski, Petar, additional, Baek, Hyun Jae, additional, Bäck, Magnus, additional, Bailey, Kent, additional, Baldo, Marcelo P., additional, Batista, Rosângela F.L., additional, Benetos, Athanasios, additional, Benjamin, Emelia J., additional, Bia, Daniel, additional, Borghi, Claudio, additional, Roux, Shani Botha-Le, additional, Breet, Yolandi, additional, Burgner, David, additional, Cardoso, Viviane C., additional, Cecelja, Marina, additional, Ceponiene, Indre, additional, Chen, Chen-Huan, additional, Cheung, Michael, additional, Cheng, Hao-min, additional, Cho, Jaegeol, additional, Chowienczyk, Phil, additional, Coelho, Eduardo B., additional, Cseprekal, Orsolya, additional, Silva, Amilcar BT Da, additional, Dallaire, Frédéric, additional, Cunha, Roberto De Sá, additional, Diaz, Alejandro, additional, Ferreira, Albano V.L., additional, Ferrières, Jean, additional, Furuta, Yoshihiko, additional, Gómez-Marcos, Manuel A., additional, Gómez-Sánchez, Leticia, additional, Halcox, Julian, additional, Hanis, Craig, additional, Herzig, Karl-Heinz, additional, Jaeggi, Edgar, additional, Kavousi, Maryam, additional, Kiechl-Kohlendorfer, Ursula, additional, Kim, Hack-Lyoung, additional, Kim, Mi-Kyung, additional, Kim, Yu-Mi, additional, Kis, Eva, additional, Knoflach, Michael, additional, Kotsis, Vasilios, additional, Koyama, Teruhide, additional, Kozakova, Michaela, additional, Kruger, Ruan, additional, Kullo, Iftikhar J., additional, Kweon, Sun-Seog, additional, Lambrinoudaki, Irene, additional, Liu, Chang, additional, Loeffler, Markus, additional, Logan, Jeongok G., additional, Maddock, Jane, additional, Magalhães, Pedro, additional, Maldonado, João, additional, Mattace-Raso, Francesco U.S., additional, Messner, Alex, additional, Meyer, Michelle L., additional, Mi, Jie, additional, Mill, José Geraldo, additional, Mitchell, Gary F., additional, Mu, Jian-Jun, additional, Muhammad, Iram F., additional, Nairz, Johannes, additional, Nakagomi, Atsushi, additional, Nakamura, Mieko, additional, Nilson, Peter M., additional, Ninomiya, Toshiharu, additional, Palombo, Carlo, additional, Pereira, Alexandre C., additional, Pereira, Telmo, additional, Capingana, Daniel P., additional, Poon, Anna K., additional, Probst-Hensch, Nicole, additional, Quyyumi, Arshed A., additional, Reusz, George S., additional, Rhee, Moo-Yong, additional, Ribeiro, Cecilia C.C., additional, Rietzschel, Ernst, additional, Rocha, Paulo R.H., additional, Rodilla, Enrique, additional, Rojek, Marta, additional, Ruidavets, Jean-Bernard, additional, Rutten, Joost H.W., additional, Saijo, Yasuaki, additional, Salvi, Paolo, additional, Schmidt-Trucksäss, Arno, additional, Scholz, Markus, additional, Shin, Min-Ho, additional, Segers, Patrick, additional, Stamatelopoulos, Kimon, additional, Strazhesko, Irina D., additional, Sugiura, Minoru, additional, Tkacheva, Olga N., additional, Tomiyama, Hirofumi, additional, Urbina, Elaine M., additional, van den Munckhof, Inge C.L., additional, Vasan, Ramachandran S., additional, Wake, Melissa A., additional, Wannamethee, Goya, additional, Wong, Andrew, additional, Yamashina, Akira, additional, Yan, Yinkun, additional, Zaniqueli, Divanei, additional, Zhu, Fang, additional, and Zócalo, Yanina, additional

Published
2023
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39. Abstract 4200: Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia Cohort Consortium

Author

Yin, Xin, primary, Kishida, Rie, additional, Abe, Sarah Krull, additional, Islam, Md. Rashedul, additional, Rahman, Md. Shafiur, additional, Saito, Eiko, additional, Lan, Qing, additional, Bletcher, Batel, additional, Merritt, Melissa, additional, Choi, Ji-Yeob, additional, Shin, Aesun, additional, Katagiri, Ryoko, additional, Shu, Xiao-Ou, additional, Sawada, Norie, additional, Tamakoshi, Akiko, additional, Koh, Woon-Puay, additional, Tsuji, Ichiro, additional, Nagata, Chisato, additional, Park, Sue K., additional, Kweon, Sun-Seog, additional, Gao, Yu-Tang, additional, Tsugane, Shoichiro, additional, Kimura, Takashi, additional, Yuan, Jian-Min, additional, Lu, Yukai, additional, Kanemura, Seiki, additional, Sugawara, Yumi, additional, Wada, Keiko, additional, Shin, Min-Ho, additional, Ahsan, Habibul, additional, Boffetta, Paolo, additional, Chia, Kee Seng, additional, Matsuo, Keitaro, additional, Qiao, You-Lin, additional, Rothman, Nathaniel, additional, Zheng, Wei, additional, Inoue, Manami, additional, Kang, Daehee, additional, and Seow, Wei Jie, additional

Published
2023
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41. Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Author

Shu, Xiang, Long, Jirong, Cai, Qiuyin, Kweon, Sun-Seog, Choi, Ji-Yeob, Kubo, Michiaki, Park, Sue K., Bolla, Manjeet K., Dennis, Joe, Wang, Qin, Yang, Yaohua, Shi, Jiajun, Guo, Xingyi, Li, Bingshan, Tao, Ran, Aronson, Kristan J., Chan, Kelvin Y. K., Chan, Tsun L., Gao, Yu-Tang, Hartman, Mikael, Kee Ho, Weang, Ito, Hidemi, Iwasaki, Motoki, Iwata, Hiroji, John, Esther M., Kasuga, Yoshio, Soon Khoo, Ui, Kim, Mi-Kyung, Kong, Sun-Young, Kurian, Allison W., Kwong, Ava, Lee, Eun-Sook, Li, Jingmei, Lophatananon, Artitaya, Low, Siew-Kee, Mariapun, Shivaani, Matsuda, Koichi, Matsuo, Keitaro, Muir, Kenneth, Noh, Dong-Young, Park, Boyoung, Park, Min-Ho, Shen, Chen-Yang, Shin, Min-Ho, Spinelli, John J., Takahashi, Atsushi, Tseng, Chiuchen, Tsugane, Shoichiro, Wu, Anna H., Xiang, Yong-Bing, Yamaji, Taiki, Zheng, Ying, Milne, Roger L., Dunning, Alison M., Pharoah, Paul D. P., García-Closas, Montserrat, Teo, Soo-Hwang, Shu, Xiao-ou, Kang, Daehee, Easton, Douglas F., Simard, Jacques, and Zheng, Wei

Published
2020
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43. The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted

Author

Scuteri, Angelo, Franco, Oscar H., Majiid, AlGhatrif, Jolita, Badariene, Sergey, Boytsov, Cheng, Hao-Min, Chen, Chen-Huan, Choi, Seong-Woo, Francesco, Cucca, De Buyzere, Marc L., Alessandro, Delitala, Marcus, Dörr, Gunnar, Engstrom, Albert, Hofman, Seul-Ki, Jeong, Kweon, Sun-Seog, Michel, Langlois, Lee, Young-Hoon, Mattace Raso, Francesco, Olle, Melander, Morrell, Cristopher H., Park, Kyeong-Soo, Rietzschel, Ernst R., Kristina, Ryliskiene, Ryliskyte, Ligita, Ulf, Schminke, David, Schlessinger, Shin, Min-Ho, Irina, Strazhesko, Shih-Hsien, Sung, Olga, Tkacheva, Völzke, Henry, Lakatta, Edward G., and Nilsson, Peter

Published
2016
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46. Leisure time sedentary behaviour and risks of breast, colorectal, and prostate cancer: A Mendelian randomization analysis

Author

Papadimitriou, Nikos, primary, Kazmi, Nabila, additional, Dimou, Niki, additional, Tsilidis, Konstantinos K, additional, Martin, Richard M, additional, Lewis, Sarah J, additional, Lynch, Brigid M, additional, Hoffmeister, Michael, additional, Kweon, Sun-Seog, additional, Li, Li, additional, Milne, Roger L, additional, Sakoda, Lori C, additional, Schoen, Robert E, additional, Phipps, Amanda I, additional, Figueiredo, Jane C, additional, Peters, Ulrike, additional, Dixon-Suen, Suzanne C., additional, Gunter, Marc J, additional, and Murphy, Neil, additional

Published
2023
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47. Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity

Author

Thomas, Minta, primary, Su, Yu-Ru, additional, Rosenthal, Elisabeth A., additional, Sakoda, Lori C, additional, Schmit, Stephanie L, additional, Timofeeva, Maria N, additional, Chen, Zhishan, additional, Fernandez-Rozadilla, Ceres, additional, Law, Philip J, additional, Murphy, Neil, additional, Carreras-Torres, Robert, additional, Diez-Obrero, Virginia, additional, van Duijnhoven, Franzel JB, additional, Jiang, Shangqing, additional, Shin, Aesun, additional, Wolk, Alicja, additional, Phipps, Amanda I, additional, Burnett-Hartman, Andrea, additional, Gsur, Andrea, additional, Chan, Andrew T, additional, Zauber, Ann G, additional, Wu, Anna H, additional, Lindblom, Annika, additional, Um, Caroline Y, additional, Tangen, Catherine M, additional, Gignoux, Chris, additional, Newton, Christina, additional, Haiman, Christopher A., additional, Qu, Conghui, additional, Bishop, D Timothy, additional, Buchanan, Daniel D, additional, Crosslin, David R., additional, Conti, David V, additional, Kim, Dong-Hyun, additional, Hauser, Elizabeth, additional, White, Emily, additional, Siegel, Erin, additional, Schumacher, Fredrick R, additional, Rennert, Gad, additional, Giles, Graham G, additional, Hampel, Heather, additional, Brenner, Hermann, additional, Oze, Isao, additional, Oh, Jae Hwan, additional, Lee, Jeffrey K, additional, Schneider, Jennifer L, additional, Chang-Claude, Jenny, additional, Kim, Jeongseon, additional, Huyghe, Jeroen R, additional, Zheng, Jiayin, additional, Hampe, Jochen, additional, Greenson, Joel, additional, Hopper, John L, additional, Palmer, Julie R, additional, Visvanathan, Kala, additional, Matsuo, Keitaro, additional, Matsuda, Koichi, additional, Jung, Keum Ji, additional, Li, Li, additional, Marchand, Loic Le, additional, Vodickova, Ludmila, additional, Bujanda, Luis, additional, Gunter, Marc J, additional, Matejcic, Marco, additional, Jenkins, Mark A, additional, Slattery, Martha L, additional, D’Amato, Mauro, additional, Wang, Meilin, additional, Hoffmeister, Michael, additional, Woods, Michael O, additional, Kim, Michelle, additional, Song, Mingyang, additional, Iwasaki, Motoki, additional, Du, Mulong, additional, Udaltsova, Natalia, additional, Sawada, Norie, additional, Vodicka, Pavel, additional, Campbell, Peter T, additional, Newcomb, Polly A, additional, Cai, Qiuyin, additional, Pearlman, Rachel, additional, Pai, Rish K, additional, Schoen, Robert E, additional, Steinfelder, Robert S, additional, Haile, Robert W, additional, Vandenputtelaar, Rosita, additional, Prentice, Ross L, additional, Küry, Sébastien, additional, Castellví-Bel, Sergi, additional, Tsugane, Shoichiro, additional, Berndt, Sonja I, additional, Lee, Soo Chin, additional, Brezina, Stefanie, additional, Weinstein, Stephanie J, additional, Chanock, Stephen J, additional, Jee, Sun Ha, additional, Kweon, Sun-Seog, additional, Vadaparampil, Susan, additional, Harrison, Tabitha A, additional, Yamaji, Taiki, additional, Keku, Temitope O, additional, Vymetalkova, Veronika, additional, Arndt, Volker, additional, Jia, Wei-Hua, additional, Shu, Xiao-Ou, additional, Lin, Yi, additional, Ahn, Yoon-Ok, additional, Stadler, Zsofia K, additional, Van Guelpen, Bethany, additional, Ulrich, Cornelia M, additional, Platz, Elizabeth A, additional, Potter, John D, additional, Li, Christopher I, additional, Meester, Reinier, additional, Moreno, Victor, additional, Figueiredo, Jane C, additional, Casey, Graham, additional, Vogelaar, Iris Landorp, additional, Dunlop, Malcolm G, additional, Gruber, Stephen B, additional, Hayes, Richard B, additional, Pharoah, Paul D P, additional, Houlston, Richard S, additional, Jarvik, Gail P, additional, Tomlinson, Ian P, additional, Zheng, Wei, additional, Corley, Douglas A, additional, Peters, Ulrike, additional, and Hsu, Li, additional

Published
2023
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