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Association of female reproductive and hormonal factors with gallbladder cancer risk in Asia: A pooled analysis of the Asia Cohort Consortium.

Authors :
Shin, Aesun
Cho, Sooyoung
Abe, Sarah Krull
Islam, Md Rashedul
Rahman, Md Shafiur
Saito, Eiko
Kazmi, Sayada Zartasha
Katagiri, Ryoko
Merritt, Melissa
Choi, Ji‐Yeob
Shu, Xiao‐Ou
Sawada, Norie
Tamakoshi, Akiko
Koh, Woon‐Puay
Sakata, Ritsu
Hozawa, Atsushi
Kim, Jeongseon
Park, Sue K.
Kweon, Sun‐Seog
Wen, Wanqing
Source :
International Journal of Cancer; Jul2024, Vol. 155 Issue 2, p240-250, 11p
Publication Year :
2024

Abstract

The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone‐related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) to assess the association between reproductive factors (age at menarche, parity, age at first delivery, breastfeeding, and age at menopause) and GBC risk. We observed that a later age at menarche was associated with an increased risk of GBC (HR 1.4, 95% CI 1.16–1.70 for 17 years and older vs. 13–14 years), especially among the cohort born in 1940 and later (HR 2.5, 95% CI 1.50–4.35). Among the cohort born before 1940, women with a later age at first delivery showed an increased risk of GBC (HR 1.56, 95% CI 1.08–2.24 for 31 years of age and older vs. 20 years of age and younger). Other reproductive factors did not show a clear association with GBC risk. Later ages at menarche and at first delivery were associated with a higher risk of GBC, and these associations varied by birth cohort. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00207136
Volume :
155
Issue :
2
Database :
Complementary Index
Journal :
International Journal of Cancer
Publication Type :
Academic Journal
Accession number :
177244147
Full Text :
https://doi.org/10.1002/ijc.34916