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1. Real-world experience with targeted therapy in patients with histiocytic neoplasms in the Netherlands and in Belgium

Author

Beckers, Erik, van den Berg, Merlijn, van den Bos, Cor, de Bree, Godelieve, Buddingh, Emmeline, Claeys, Kristl, van Daele, Paul, De Haes, Petra, Demandt, Astrid, van Dorp, Suzanne, Hak, Liesbeth, van Halteren, Astrid, van der Houwen, Tim, Jak, Margot, Kerstens, Jeroen, Kwakernaak, Arjan, van Laar, Jan, Leavis, Helen, Leguit, Roos, van de Loosdrecht, Arjan, Morsink, Linde, Mous, Rogier, van Noesel, Max, Oostvogels, Rimke, Potjewijd, Judith, Plattel, Wouter, Roeloffzen, Wilfried, Rutgers, Abraham, Tonino, Sanne, Tousseyn, Thomas, Verdijk, Rob, Vermaat, Joost, Woei-A-Jin, Sherida, Kemps, Paul G., Woei-A-Jin, F. J. Sherida H., Schöffski, Patrick, Vanden Bempt, Isabelle, Meyer-Wentrup, Friederike A. G., Dors, Natasja, van Eijkelenburg, Natasha K. A., Scheijde-Vermeulen, Marijn A., Jazet, Ingrid M., Limper, Maarten, Verdijk, Robert M., Donker, Marjolein L., de Jonge, Nick A., van Noesel, Carel J. M., Hebeda, Konnie M., Tonino, Sanne H., van Laar, Jan A. M., and van Halteren, Astrid G. S.

Published
2024
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3. Self-Monitoring and Self-Efficacy in Patients with Chronic Kidney Disease During Low-Sodium Diet Self-Management Interventions: Secondary Analysis of the ESMO and SUBLIME Trials.

Author

Hoekstra, Tiny, Dam, Manouk, Klaassen, Gerald, Bos, Willem Jan W., van der Boog, Paul J. M., Vogt, Liffert, van Jaarsveld, Brigit, van Dijk, Sandra, Navis, Gerjan, Meuleman, Yvette, on behalf of ESMO, Dekker, Friedo W, van der Boog, Paul J M, Bos, Willem Jan W, van Montfrans, Gert A, Boeschoten, Elisabeth W, Verduijn, Marion, ten Brinke, Lucia, Spijker, Anke, and Kwakernaak, Arjan J

Abstract

Background: Patients with chronic kidney disease are often requested to engage in self-monitoring sodium (i.e. salt) intake, but it is currently unknown how self-monitoring would empower them. This study aims to assess: (1) how frequent self-monitoring tools are being used during low-sodium diet self-management interventions; (2) whether self-efficacy (i.e. trust in own capability to manage the chronic disease) is associated with self-monitoring frequency; and (3) whether higher self-monitoring frequency is associated with an improvement in self-efficacy over time. Method: Data from two multicenter randomized controlled trials (ESMO [n = 151] and SUBLIME [n = 99]) among adult Dutch patients with chronic kidney disease (eGFR ≥ 20–25 mL/min/1.73 m2) were used. In both studies, routine care was compared to a 3-month low-sodium diet self-management intervention with several self-monitoring tools (online food diary, home blood pressure monitor, and urinary sodium measurement device [only ESMO]). Data was collected on usage frequency of self-monitoring tools. Frequencies during the interventions were compared between low and high baseline self-efficacy groups using the Mann-Whitney U test and T-test and associated with changes in self-efficacy during the interventions using Spearman correlation coefficients. Results: Large variations in self-monitoring frequency were observed. In both interventions, usage of self-monitoring tools was highest during the first month with sharp drops thereafter. The online food diary was the most frequently used tool. In the ESMO intervention, low baseline self-efficacy was associated with a higher usage frequency of self-monitoring tools. This finding was not confirmed in the SUBLIME intervention. No significant associations were found between usage frequency of self-monitoring tools and changes in self-efficacy over time. Conclusion: Patients with low self-efficacy might benefit most from frequent usage of self-monitoring tools when sufficient guidance and support is provided. [ABSTRACT FROM AUTHOR]

Published
2025
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4. Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS

Author

van der Made, Caspar I., Potjewijd, Judith, Hoogstins, Annemiek, Willems, Huub P.J., Kwakernaak, Arjan J., de Sevaux, Ruud G.L., van Daele, Paul L.A., Simons, Annet, Heijstek, Marloes, Beck, David B., Netea, Mihai G., van Paassen, Pieter, Elizabeth Hak, A., van der Veken, Lars T., van Gijn, Marielle E., Hoischen, Alexander, van de Veerdonk, Frank L., Leavis, Helen L., and Rutgers, Abraham

Published
2022
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10. Clinical and clonal characteristics of monoclonal immunoglobulin M‐associated type I cryoglobulinaemia

Author

Khwaja, Jahanzaib, primary, Vos, Josephine M. I., additional, Pluimers, Tessa E., additional, Japzon, Nicole, additional, Patel, Aisha, additional, Salter, Simon, additional, Kwakernaak, Arjan J., additional, Gupta, Rajeev, additional, Rismani, Ali, additional, Kyriakou, Charalampia, additional, Wechalekar, Ashutosh D., additional, and D'Sa, Shirley, additional

Published
2023
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11. Sodium Restriction in Patients With CKD: A Randomized Controlled Trial of Self-management Support

Author

van Dijk, Sandra, Meuleman, Yvette, Dekker, Friedo W., Hoekstra, Tiny, Navis, Gerjan, Vogt, Liffert, van der Boog, Paul J.M., Bos, Willem Jan W., van Montfrans, Gert A., Boeschoten, Elisabeth W., Verduijn, Marion, ten Brinke, Lucia, Spijker, Anke, Kwakernaak, Arjan J., Humalda, Jelmer K., van Hirtum, Tonnie, Bokelaar, Robin, Loos, Marie-Louise, Bakker-Edink, Anke, Poot, Charlotte, Ciere, Yvette, Zwaard, Sophie, Veldscholte, Glenn, Heuveling, Lara, Storm, Marjolein, and Prantl, Karen

Published
2017
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12. Clinical and clonal characteristics of monoclonal immunoglobulin M‐associated type I cryoglobulinaemia.

Author

Khwaja, Jahanzaib, Vos, Josephine M. I., Pluimers, Tessa E., Japzon, Nicole, Patel, Aisha, Salter, Simon, Kwakernaak, Arjan J., Gupta, Rajeev, Rismani, Ali, Kyriakou, Charalampia, Wechalekar, Ashutosh D., and D'Sa, Shirley

Subjects
NON-Hodgkin's lymphoma, WALDENSTROM'S macroglobulinemia, HOCKEY, PERIPHERAL neuropathy, OVERALL survival, MYELOID differentiation factor 88
Abstract

Summary: Monoclonal immunoglobulin M‐associated type I cryoglobulinaemia is poorly characterised. We screened 534 patients with monoclonal IgM disorders over a 9‐year period and identified 134 patients with IgM type I cryoglobulins. Of these, 76% had Waldenström macroglobulinaemia (WM), 5% had other non‐Hodgkin lymphoma (NHL) and 19% had IgM monoclonal gammopathy of undetermined significance (MGUS). Clinically relevant IgM‐associated disorders (including cold agglutinin disease [CAD], anti‐MAG antibodies, amyloidosis and Schnitzler syndrome) coexisted in 31%, more frequently in MGUS versus WM/NHL (72% vs. 22%/29%, p < 0.001). The majority of those with cryoglobulins and coexistent CAD/syndrome had the molecular characteristics of a CAD clone (wild‐type MYD88 in 80%). A half of all patients had active manifestations at cryoglobulin detection: vasomotor (22%), cutaneous (16%), peripheral neuropathy (22%) and hyperviscosity (9%). 16/134 required treatment for cryoglobulin‐related symptoms alone at a median of 38 days (range: 6–239) from cryoglobulin detection. At a median follow‐up of 3 years (range: 0–10), 3‐year cryoglobulinaemia‐treatment‐free survival was 77% (95% CI: 68%–84%). Age was the only predictor of overall survival. Predictors of cryoglobulinaemia‐related treatment/death were hyperviscosity (HR: 73.01; 95% CI: 15.62–341.36, p < 0.0001) and cutaneous involvement (HR: 2.95; 95% CI: 1.13–7.71, p = 0.028). Type I IgM cryoglobulinaemia is more prevalent than previously described in IgM gammopathy and should be actively sought. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Perceived Sodium Reduction Barriers Among Patients with Chronic Kidney Disease: Which Barriers Are Important and Which Patients Experience Barriers?

Author

Meuleman, Yvette, Hoekstra, Tiny, Dekker, Friedo W., van der Boog, Paul J. M., van Dijk, Sandra, van Dijk, Sandra, Meuleman, Yvette, Dekker, Friedo W., Hoekstra, Tiny, Navis, Gerjan, Vogt, Liffert, van der Boog, Paul J. M., Bos, Willem Jan W., van Montfrans, Gert A., Boeschoten, Elisabeth W., Verduijn, Marion, ten Brinke, Lucia, Heuveling, Lara, Storm, Marjolein, Prantl, Karen, Spijker, Anke, Kwakernaak, Arjan J., Humalda, Jelmer K., van Hirtum, Tonnie, Bokelaar, Robin, Loos, Marie-Louise, Bakker-Edink, Anke, Poot, Charlotte, Ciere, Yvette, Zwaard, Sophie, Veldscholte, Glenn, and The ESMO study group

Published
2017
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22. Uw diagnose?

Author

Kwakernaak, Arjan J., Bernelot Moens, Sophie J., Hilhorst, Marc L., Florquin, Sandrine, van de Donk, Niels C. W. J., Vos, J.M., Nephrology, Clinical Haematology, 01 Internal and external specialisms, ACS - Atherosclerosis & ischemic syndromes, Pathology, General Internal Medicine, and CCA - Cancer biology and immunology

Subjects
amyloïdose, M. Waldenström, nefrotisch syndroom
Published
2022

24. Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS

Author

Made, C.I. van der, Potjewijd, J., Hoogstins, Annemiek, Willems, Huub P. J., Kwakernaak, Arjan J., Sevaux, R.G.L. de, Simons, A., Netea, M.G., Hoischen, A., Veerdonk, F.L. van de, Leavis, H.L., Rutgers, Abraham, Made, C.I. van der, Potjewijd, J., Hoogstins, Annemiek, Willems, Huub P. J., Kwakernaak, Arjan J., Sevaux, R.G.L. de, Simons, A., Netea, M.G., Hoischen, A., Veerdonk, F.L. van de, Leavis, H.L., and Rutgers, Abraham

Abstract

Item does not contain fulltext

Published
2022

29. The Biobank of Nephrological Diseases in the Netherlands cohort: the String of Pearls Initiative collaboration on chronic kidney disease in the university medical centers in the Netherlands

Author

Navis, Gerjan J., Blankestijn, Peter J., Deegens, Jeroen, De Fijter, Johan W., Homan van der Heide, Jaap J., Rabelink, Ton, Krediet, Raymond T., Kwakernaak, Arjan J., Laverman, Gozewijn D., Leunissen, Karel M., van Paassen, Pieter, Vervloet, Marc G., Wee, Pieter M. Ter, Wetzels, Jack F., Zietse, Robert, and van Ittersum, Frans J.

Published
2014
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36. Sodium Restriction in Patients With CKD: A Randomized Controlled Trial of Self-management Support

Author

Meuleman, Yvette, primary, Hoekstra, Tiny, additional, Dekker, Friedo W., additional, Navis, Gerjan, additional, Vogt, Liffert, additional, van der Boog, Paul J.M., additional, Bos, Willem Jan W., additional, van Montfrans, Gert A., additional, van Dijk, Sandra, additional, Meuleman, Yvette, additional, Boeschoten, Elisabeth W., additional, Verduijn, Marion, additional, ten Brinke, Lucia, additional, Spijker, Anke, additional, Kwakernaak, Arjan J., additional, Humalda, Jelmer K., additional, van Hirtum, Tonnie, additional, Bokelaar, Robin, additional, Loos, Marie-Louise, additional, Bakker-Edink, Anke, additional, Poot, Charlotte, additional, Ciere, Yvette, additional, Zwaard, Sophie, additional, Veldscholte, Glenn, additional, Heuveling, Lara, additional, Storm, Marjolein, additional, and Prantl, Karen, additional

Published
2017
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38. Hydrogen sulfide attenuates angiotensin II-induced hypertension, proteinuria and renal damage

Author

Frenay, Anne-Roos S., Snijder, Pauline M., Koning, Anne M., Bachtler, Matthias, Pasch, Andreas, Kwakernaak, Arjan J., van den Berg, Else, Bos, Eelke M., Hillebrands, Jan-Luuk, Navis, Gerjan, Leuvenink, Henri G. D., van Goor, Harry, Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Lifestyle Medicine (LM), and Groningen Institute for Organ Transplantation (GIOT)

Published
2014

40. Extremely low high-density-lipoprotein cholesterol due to an unusual non-inherited cause: a case report.

Author

Kwakernaak, Arjan J., Post, Marco C., Pijlman, Annemarie H., and Bosma, Madeleen

Subjects
*PULMONARY embolism, *VITAMIN K, *MAGNETIC resonance imaging, *MYOCARDITIS, *HIGH density lipoproteins
Abstract

The article presents a case study of 31-year-old white male known with a factor V Leiden mutation and recurrent pulmonary embolism for which he used lifelong vitamin K antagonist. The patient underwent magnetic resonance imaging (MRI) which confirmed myocarditis and showed increased mid-myocardial late enhancement of the lateral wall of the left ventricle. It informs that routine lipid measurement showed an extremely low high-density lipoprotein-cholesterol.

Published
2019
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42. Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

Author

Padmanabhan, Sandosh, Melander, Olle, Johnson, Toby, Di Blasio, Anna Maria, Lee, Wai K., Gentilini, Davide, Hastie, Claire E., Menni, Cristina, Monti, Maria Cristina, Delles, Christian, Laing, Stewart, Corso, Barbara, Navis, Gerjan, Kwakernaak, Arjan J., van der Harst, Pim, Bochud, Murielle, Maillard, Marc, Burnier, Michel, Hedner, Thomas, Kjeldsen, Sverre, Wahlstrand, Bjorn, Sjögren, Marketa, Fava, Cristiano, Montagnana, Martina, Danese, Elisa, Torffvit, Ole, Hedblad, Bo, Snieder, Harold, Connell, John M. C., Brown, Morris, Samani, Nilesh J., Farrall, Martin, Cesana, Giancarlo, Mancia, Giuseppe, Signorini, Stefano, Grassi, Guido, Eyheramendy, Susana, Wichmann, H. Erich, Laan, Maris, Strachan, David P., Sever, Peter, Shields, Denis Colm, Stanton, Alice, Vollenweider, Peter, Teumer, Alexander, Voelzke, Henry, Rettig, Rainer, Newton-Cheh, Christopher, Arora, Pankaj, Zhang, Feng, Soranzo, Nicole, Spector, Timothy D., Lucas, Gavin, Kathiresan, Sekar, Siscovick, David S., Luan, Jian'an, Loos, Ruth J. F., Wareham, Nicholas J., Penninx, Brenda W., Nolte, Ilja M., McBride, Martin, Miller, William H., Nicklin, Stuart A., Baker, Andrew H., Graham, Delyth, McDonald, Robert A., Pell, Jill P., Sattar, Naveed, Welsh, Paul, Munroe, Patricia, Caulfield, Mark J., Zanchetti, Alberto, and Dominiczak, Anna F.

Subjects
Urology and Nephrology, Cardiac and Cardiovascular Systems
Abstract

Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We conducted a genome-wide association study in 1,621 hypertensive cases and 1,699 controls and follow-up validation analyses in 19,845 cases and 16,541 controls using an extreme case-control design. We identified a locus on chromosome 16 in the 59 region of Uromodulin (UMOD; rs13333226, combined P value of 3.6x10(-11)). The minor G allele is associated with a lower risk of hypertension (OR [95% CI]: 0.87 [0.84-0.91]), reduced urinary uromodulin excretion, better renal function; and each copy of the G allele is associated with a 7.7% reduction in risk of CVD events after adjusting for age, sex, BMI, and smoking status (H.R. = 0.923, 95% CI 0.860-0.991; p = 0.027). In a subset of 13,446 individuals with estimated glomerular filtration rate (eGFR) measurements, we show that rs13333226 is independently associated with hypertension (unadjusted for eGFR: 0.89 [0.83-0.96], p = 0.004; after eGFR adjustment: 0.89 [0.83-0.96], p = 0.003). In clinical functional studies, we also consistently show the minor G allele is associated with lower urinary uromodulin excretion. The exclusive expression of uromodulin in the thick portion of the ascending limb of Henle suggests a putative role of this variant in hypertension through an effect on sodium homeostasis. The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk.

Published
2010

45. Perceived Barriers and Support Strategies for Reducing Sodium Intake in Patients with Chronic Kidney Disease: a Qualitative Study

Author

Meuleman, Yvette, primary, ten Brinke, Lucia, additional, Kwakernaak, Arjan J., additional, Vogt, Liffert, additional, Rotmans, Joris I., additional, Bos, Willem Jan W., additional, van der Boog, Paul J. M., additional, Navis, Gerjan, additional, van Montfrans, Gert A., additional, Hoekstra, Tiny, additional, Dekker, Friedo W., additional, and van Dijk, Sandra, additional

Published
2014
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46. P25 Hydrogen sulfide attenuates angiotensin II-induced hypertension, proteinuria and renal damage

Author

Frenay, Anne-Roos S., primary, Snijder, Pauline M., additional, Koning, Anne M., additional, Bachtler, Matthias, additional, Pasch, Andreas, additional, Kwakernaak, Arjan J., additional, van den Berg, Else, additional, Bos, Eelke M., additional, Hillebrands, Jan-Luuk, additional, Navis, Gerjan, additional, Leuvenink, Henri G.D., additional, and van Goor, Harry, additional

Published
2014
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