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173 results on '"Kuroda, Yuko"'

1. MYC Causes Multiple Myeloma Progression via Attenuating TP53-Induced MicroRNA-34 Expression

Author

Murakami, Yuki, primary, Kimura-Masuda, Kei, additional, Oda, Tsukasa, additional, Matsumura, Ikuko, additional, Masuda, Yuta, additional, Ishihara, Rei, additional, Watanabe, Saki, additional, Kuroda, Yuko, additional, Kasamatsu, Tetsuhiro, additional, Gotoh, Nanami, additional, Takei, Hisashi, additional, Kobayashi, Nobuhiko, additional, Saitoh, Takayuki, additional, Murakami, Hirokazu, additional, and Handa, Hiroshi, additional

Published
2022
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4. Long non‐coding RNA MALAT1 is an inducible stress response gene associated with extramedullary spread and poor prognosis of multiple myeloma

Author

Handa, Hiroshi, Kuroda, Yuko, Kimura, Kei, Masuda, Yuta, Hattori, Hikaru, Alkebsi, Lobna, Matsumoto, Morio, Kasamatsu, Tetsuhiro, Kobayashi, Nobuhiko, Tahara, Ken‐ichi, Takizawa, Makiko, Koiso, Hiromi, Ishizaki, Takuma, Shimizu, Hiroaki, Yokohama, Akihiko, Tsukamoto, Norifumi, Saito, Takayuki, and Murakami, Hirokazu

Published
2017
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7. MYC Causes Multiple Myeloma Progression via Attenuating TP53-Induced MicroRNA-34 Expression.

Author

Murakami, Yuki, Kimura-Masuda, Kei, Oda, Tsukasa, Matsumura, Ikuko, Masuda, Yuta, Ishihara, Rei, Watanabe, Saki, Kuroda, Yuko, Kasamatsu, Tetsuhiro, Gotoh, Nanami, Takei, Hisashi, Kobayashi, Nobuhiko, Saitoh, Takayuki, Murakami, Hirokazu, and Handa, Hiroshi

Subjects
GENE expression, BASE pairs, NON-coding RNA, PLASMA cells, MULTIPLE myeloma, CELL lines, B cells
Abstract

MicroRNAs (miRNAs and miRs) are small (19–25 base pairs) non-coding RNAs with the ability to modulate gene expression. Previously, we showed that the miR-34 family is downregulated in multiple myeloma (MM) as the cancer progressed. In this study, we aimed to clarify the mechanism of miRNA dysregulation in MM. We focused particularly on the interaction between MYC and the TP53-miR34 axis because there is a discrepancy between increased TP53 and decreased miR-34 expressions in MM. Using the nutlin-3 or Tet-on systems, we caused wild-type (WT) p53 protein accumulation in human MM cell lines (HMCLs) and observed upregulated miR-34 expression. Next, we found that treatment with an Myc inhibitor alone did not affect miR-34 expression levels, but when it was coupled with p53 accumulation, miR-34 expression increased. In contrast, forced MYC activation by the MYC-ER system reduced nutlin-3-induced miR-34 expression. We also observed that TP53 and MYC were negatively correlated with mature miR-34 expressions in the plasma cells of patients with MM. Our results suggest that MYC participates in the suppression of p53-dependent miRNA expressions. Because miRNA expression suppresses tumors, its inhibition leads to MM development and malignant transformation. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Interdisciplinary therapy for severe periodontitis with Angle Class II Division 1 malocclusion : A case report with 7-year follow-up

Author

Iwata, Mitsuhiro, Saito, Atsushi, Kuroda, Yuko, Shinohara, Takehiro, and Tanaka, Eiji

Subjects
periodontal regenerative therapy, dental implant, occlusal trauma, implant-anchored orthodontic treatment, Interdisciplinary therapy
Abstract

Background: Previous studies have suggested that occlusal discrepancy is a risk factor contributing to periodontal disease. 1-3 Occlusal discrepancy could increase the risk of infrabony defects. This is a case of a patient with severe periodontitis who exhibited many infrabony defects in the molar region due to malocclusion-induced trauma. Here, we report the 7-year prognosis of the patient after periodontal regenerative and comprehensive orthodontic therapies for functional recovery with implant prosthodontics. Case Description: A 54-year-old female presented with the chief complaint of masticatory disturbance. In the molar region, significant tooth mobility, deep periodontal pockets, and infrabony defects were observed. She had excessive overjet, resulting in collapse of anterior guidance. Malocclusion was considered to be an exacerbating factor of the infrabony defects. After initial periodontal therapy, we performed periodontal regenerative therapy in the mandibular molar regions. We carefully placed implants in a position in the maxillary molar region that would ensure an appropriate anterior dental relationship after orthodontic treatment. Comprehensive orthodontic treatment was subsequently performed using implants as anchoring units. Then, definitive surgery was performed on the mandibular molars before placing the final prosthesis. A favorable periodontal condition and a stable occlusion have been maintained for the 7-year post-treatment period. Practical Implications: Comprehensive and interdisciplinary treatment enables stable occlusion and establishment of periodontal tissue and peri-implant tissues with high cleansability, even in patients with severe periodontitis and malocclusion. In the present case, a favorable long-term treatment outcome can be expected.

Published
2019

11. Comprehensive treatment for severe periodontitis with pathologic tooth migration−related bimaxillary protrusion : A case report with 3-year follow-up

Author

Iwata, Mitsuhiro, Saito, Atsushi, Kuroda, Yuko, Shinohara, Takehiro, Arai, Daishi, Horie, Hirofumi, Tanaka, Eiji, Iwata, Mitsuhiro, Saito, Atsushi, Kuroda, Yuko, Shinohara, Takehiro, Arai, Daishi, Horie, Hirofumi, and Tanaka, Eiji

Abstract

Background: Patients with severe periodontitis often experience pathologic tooth migration (PTM), which impairs esthetics and leads to occlusal disharmony (e.g., premature contacts and/or traumatic occlusion) that can further exacerbate periodontitis. Here, we describe a patient who exhibited severe periodontitis with PTM-related bimaxillary protrusion. This report includes 3-year clinical outcomes following periodontal regenerative therapy, implant-anchored orthodontic therapy, and implant prosthodontics intended to achieve both functional and esthetic improvements. Case Description: A 63-year-old woman presented with the chief complaint of upper anterior tooth mobility. Clinical examination revealed excessive tooth mobility, deep periodontal pockets, and infrabony defects in all teeth. All teeth exhibited PTM; the mandibular anterior teeth exhibited marked protrusion caused by the progression of periodontitis. After initial periodontal therapy, periodontal regenerative therapy was performed in all molar regions. At 9 and 6 months postoperatively, comprehensive orthodontic treatment was initiated for the mandible and maxilla, respectively, using orthodontic anchorage devices to achieve acceptable functional occlusion. After orthodontic treatment, staged guided bone regeneration was performed and dental implants were placed in the severely resorbed maxillary anterior ridge. This comprehensive treatment yielded favorable periodontal conditions, stable occlusion, and good esthetic outcomes. Practical Implications: Favorable esthetics, stable occlusion, and highly cleansable periodontal tissues were achieved with well-planned interdisciplinary and comprehensive treatment, although the patient had severe periodontitis and PTM-related bimaxillary protrusion.

Published
2021

13. Long Noncoding RNA PVT1 Is Regulated by Bromodomain Protein BRD4 in Multiple Myeloma and Is Associated with Disease Progression

Author

Handa, Hiroshi, primary, Honma, Kazuki, additional, Oda, Tsukasa, additional, Kobayashi, Nobuhiko, additional, Kuroda, Yuko, additional, Kimura-Masuda, Kei, additional, Watanabe, Saki, additional, Ishihara, Rei, additional, Murakami, Yuki, additional, Masuda, Yuta, additional, Tahara, Ken-ichi, additional, Takei, Hisashi, additional, Kasamatsu, Tetsuhiro, additional, Saitoh, Takayuki, additional, and Murakami, Hirokazu, additional

Published
2020
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16. Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma

Author

Kobayashi, Nobuhiko, primary, Oda, Tsukasa, additional, Takizawa, Makiko, additional, Ishizaki, Takuma, additional, Tsukamoto, Norifumi, additional, Yokohama, Akihiko, additional, Takei, Hisashi, additional, Saitoh, Takayuki, additional, Shimizu, Hiroaki, additional, Honma, Kazuki, additional, Kimura-Masuda, Kei, additional, Kuroda, Yuko, additional, Ishihara, Rei, additional, Murakami, Yuki, additional, Murakami, Hirokazu, additional, and Handa, Hiroshi, additional

Published
2020
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25. The Literature Review of NANDA-I Nursing Diagnosis 'Death Anxiety'

Author

Shimomai, Kimiyo, Furukawa, Hidetoshi, Hayashi, Miyoko, and Kuroda, Yuko

Subjects
NANDA-International nursing diagnosis, 文献検討, literature review, 死の不安, death anxiety, NANDA-International看護診断
Abstract

【目的】NANDA-International看護診断分類(以下,NANDA-I看護診断)看護診断"死の不安"に関連する既存研究からどのようなことが明らかにされているのかを探究する。【方法】本研究は文献研究デザインである。検索方法は,国内文献では医学中央雑誌Web版を用いて「死の不安」と「看護診断」をキーワードに,海外文献ではPubMedWeb版を用いて「deathanxiety」と「nursingdiagnosis」をキーワードに,1995年から2012年までの学術雑誌に掲載された抄録のある文献を検索し,統合した。【結果】1.NANDA-I看護診断"死の不安"に関する研究は,国内文献では検索できず,海外文献で,終末期乳がん患者のカルテに記載された看護診断に関する日本で実施された研究を英語で報告した1件(Ogasawaraetal.,2005)が検索された。2.死の不安に関する文献では,国内文献5件はすべて量的研究であった。【考察】今回検索された結果より,文献のほとんどが量的研究であり,死の不安を独立変数もしくは従属変数として扱った文献が数多くあった。死の不安は,年齢や疼痛・褥瘡といった身体的要因,鬱症状や再発の恐怖といった心理社会的要因,生きる目的や死後に対する信念といった霊的要因という人間存在のすべての側面に関係する要因が存在することが示唆された。しかし,これらの要因は,現在のNANDA-I看護診断"死の不安"の診断指標や関連因子には反映されていない。このことから,文献で示唆された要因を,現行のNANDA-I看護診断"死の不安"の診断指標・関連因子と照合し洗練させる必要があると考える。

Published
2015

26. Effectiveness of presurgical nasoalveolar molding therapy on unilateral cleft lip nasal deformity

Author

Kinouchi, Nao, Horiuchi, Shinya, Yasue, Akihiro, Kuroda, Yuko, Kawai, Nobuhiko, Watanabe, Keiichiro, Izawa, Takashi, Hashimoto, Ichiro, Hassan, Ali H., Tanaka, Eiji, Kinouchi, Nao, Horiuchi, Shinya, Yasue, Akihiro, Kuroda, Yuko, Kawai, Nobuhiko, Watanabe, Keiichiro, Izawa, Takashi, Hashimoto, Ichiro, Hassan, Ali H., and Tanaka, Eiji

Abstract

Objectives: To evaluate the effectiveness of pre-surgical nasoalveolar molding (PNAM) in patients with unilateral cleft lip nasal deformities. Methods: This was a retrospective study involving 29 patients with unilateral cleft lip and palate defects, of whom 13 were treated with palatal devices with nasal stents (PNAM group) and 16 were treated with palatal devices without nasal stents or surgical tapes (control group). Submental oblique photographs and orthodontic models were longitudinally obtained at the initial visit (T1) and immediately before (T2) and after cheiloplasty (T3). Asymmetry of the external nose, degree of columellar shifting, nasal tip/ala nose ratio, nasal base angle, interalveolar gap, and the sagittal difference in the alveolar gap were measured. The study was conducted in the Orthodontic Clinic at Tokushima University Hospital, Tokushima, Japan between 1997 and 2012. Results: At T1, there were no significant intergroup differences in the first 4 asymmetry parameters. At T2, the PNAM group showed a significant improvement in all values compared to the control group. At T3, the PNAM group showed significant improvement in nasal asymmetry and columellar shifting. Model analysis showed significantly greater changes in the inter-alveolar gap and the sagittal difference of the alveolar cleft gap from T1 to T2 in the PNAM group. Conclusion: The use of PNAM is indispensable for pre-surgical orthodontic treatment at the early postnatal age.

Published
2018

29. Long Non-Coding RNA NEAT1 Is Upregulated By Heat Shock Factor 1 (HSF1) and Associated with Multiple Myeloma Progression

Author

Watanabe, Saki, primary, Oda, Tsukasa, additional, Kuroda, Yuko, additional, Homma, Kazuki, additional, Murakami, Yuki, additional, Ishihara, Rei, additional, Yamane, Eiko, additional, Sunaga, Masanobu, additional, Kobayashi, Nobuhiko, additional, Osaki, Yohei, additional, Ishizaki, Takuma, additional, Shimizu, Hiroaki, additional, Koiso, Hiromi, additional, Iriuchishima, Hirono, additional, Takizawa, Makiko, additional, Yokohama, Akihiko, additional, Tsukamoto, Norifumi, additional, Nanami, Gotoh, additional, Ino, Rumi, additional, Saitoh, Takayuki, additional, Murakami, Hirokazu, additional, and Handa, Hiroshi, additional

Published
2018
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34. Chronic repetitive transcranial magnetic stimulation failed to change dopamine synthesis rate: Preliminary L-[beta-11C]DOPA positron emission tomography study in patients with depression

Author

Kuroda, Yuko, Motohashi, Nobutaka, Ito, Hiroshi, Ito, Shigeo, Takano, Akihiro, Takahashi, Hidehiko, Nishikawa, Touru, and Suhara, Tetsuya

Subjects
nervous system, musculoskeletal, neural, and ocular physiology, mental disorders, behavioral disciplines and activities, psychological phenomena and processes
Abstract

We have examined the effects of repetitive transcranial magnetic stimulation (rTMS) on central dopaminergic function in patients with depression using positron emission tomography with L-[beta-11C]DOPA, a ligand to assess the rate of endogenous dopamine synthesis. Eight patients were treated with 10-daily sessions of rTMS over the left dorsolateral prefrontal cortex. Positron emission tomography scanning was performed in each patient twice, before the first session and 1 day after the last session. Although four out of eight patients responded to rTMS, there were no changes in the striatal dopamine synthesis rate (k) following rTMS. These results suggest that chronic rTMS had a limited effect on the dopaminergic system.

Published
2010

36. Long non-coding RNAMALAT1is an inducible stress response gene associated with extramedullary spread and poor prognosis of multiple myeloma

Author

Handa, Hiroshi, primary, Kuroda, Yuko, additional, Kimura, Kei, additional, Masuda, Yuta, additional, Hattori, Hikaru, additional, Alkebsi, Lobna, additional, Matsumoto, Morio, additional, Kasamatsu, Tetsuhiro, additional, Kobayashi, Nobuhiko, additional, Tahara, Ken-ichi, additional, Takizawa, Makiko, additional, Koiso, Hiromi, additional, Ishizaki, Takuma, additional, Shimizu, Hiroaki, additional, Yokohama, Akihiko, additional, Tsukamoto, Norifumi, additional, Saito, Takayuki, additional, and Murakami, Hirokazu, additional

Published
2017
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39. Pharmacokinetics and skin-tissue penetration of daptomycin in rats

Author

Matsumoto,Kazuaki, Kitaoka,Masashi, Kuroda,Yuko, Ikawa,Kazuro, Morikawa,Norifumi, Sasaki,Junichi, Iketani,Osamu, Iwata,Satoshi, Horino,Tetsuya, Hori,Seiji, Kizu,Junko, Matsumoto,Kazuaki, Kitaoka,Masashi, Kuroda,Yuko, Ikawa,Kazuro, Morikawa,Norifumi, Sasaki,Junichi, Iketani,Osamu, Iwata,Satoshi, Horino,Tetsuya, Hori,Seiji, and Kizu,Junko

Abstract

Kazuaki Matsumoto,1 Masashi Kitaoka,1 Yuko Kuroda,1 Kazuro Ikawa,2 Norifumi Morikawa,2 Junichi Sasaki,3 Osamu Iketani,4 Satoshi Iwata,4 Tetsuya Horino,5 Seiji Hori,5 Junko Kizu1 1Division of Practical Pharmacy, Keio University Faculty of Pharmacy, Tokyo, 2Department of Clinical Pharmacotherapy, Hiroshima University, Hiroshima, 3Department of Emergency and Critical Care Medicine, 4Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 5Department of Infectious Diseases and Infection Control, Jikei University School of Medicine, Tokyo, Japan Background: Daptomycin is recommended for complicated skin and skin-structure infections. However, information on the penetration of daptomycin into skin is limited. Therefore, the aim of this in vivo investigation was to determine the pharmacokinetics and skin penetration of daptomycin in rats. Materials and methods: Concentrations of daptomycin were determined by high-performance liquid chromatography. A noncompartmental pharmacokinetic analysis was conducted to estimate the rate and extent of daptomycin penetration from the systemic circulation into skin tissue. Since protein binding of daptomycin in rat serum was 89.3%, the free maximum concentration (Cmax) and free area under the curve from time 0 to infinity (AUC0–∞) for plasma were calculated as follows: fCmax, plasma = (1 – 0.893) × Cmax, plasma, fAUC0–∞, plasma = (1 – 0.893) × AUC0–∞, plasma. Results: The following values (mean ± standard deviation) were obtained: 0.06±0 L/h/kg for total clearance (CLtotal), 0.44±0.06 hours for elimination-rate constant, 1.58±0.23 hours for half-life, 0.14±0.02 L/kg for steady-state volume distribution, and 2.28±0.33 hours for mean residence time. Time to Cmax was 3.0 hours for plasma and skin tissue. Cmax and AUC0–∞ for

Published
2015

40. Loop Regulation Between microRNAs and Epigenetics Underlie microRNA Dysregulation in Multiple Myeloma and Is Associated with the Disease Progression

Author

Kimura, Kei, primary, Kuroda, Yuko, additional, Masuda, Yuta, additional, Yamane, Arito, additional, Hattori, Hikaru, additional, Tahara, Kenichi, additional, Kaneko, Ayaka, additional, Suda, Itsumi, additional, Takahashi, Noriyuki, additional, Gotoh, Nanami, additional, Nagai, Kie, additional, Nagashima, Tomomi, additional, Saitoh, Takayuki, additional, Iriuchishima, Hirono, additional, Takizawa, Makiko, additional, Koiso, Hiromi, additional, Ishizaki, Takuma, additional, Mitsui, Takeki, additional, Shimizu, Hiroaki, additional, Yokohama, Akihiko, additional, Tsukamoto, Norifumi, additional, Kasamatsu, Tetsuhiro, additional, Minato, Yusuke, additional, Nojima, Yoshihisa, additional, Murakami, Hirokazu, additional, and Handa, Hiroshi, additional

Published
2015
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41. Long Non-Coding RNA MALAT1 Is Associated with the Progression of Multiple Myeloma and Induced By Cellular Stress

Author

Kuroda, Yuko, primary, Kimura, Kei, additional, Masuda, Yuta, additional, Yamane, Arito, additional, Hattori, Hikaru, additional, Tahara, Kenichi, additional, Kaneko, Ayaka, additional, Suda, Itsumi, additional, Takahashi, Noriyuki, additional, Nanami, Gotoh, additional, Nagai, Kie, additional, Nagashima, Tomomi, additional, Takizawa, Makiko, additional, Koiso, Hiromi, additional, Ishizaki, Takuma, additional, Mitsui, Takeki, additional, Iriuchishima, Hirono, additional, Saitoh, Takayuki, additional, Shimizu, Hiroaki, additional, Yokohama, Akihiko, additional, Tsukamoto, Norifumi, additional, Kasamatsu, Tetsuhiro, additional, Minato, Yusuke, additional, Nojima, Yoshihisa, additional, Murakami, Hirokazu, additional, and Handa, Hiroshi, additional

Published
2015
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42. Th1 Polarization of Cytokine and Cytokine Receptor Polymorphisms Affect the Susceptibility and Severity of ITP

Author

Takahashi, Noriyuki, primary, Saitoh, Takayuki, additional, Gotoh, Nanami, additional, Kimura, Kei, additional, Kuroda, Yuko, additional, Nagai, Kie, additional, Nagashima, Tomomi, additional, Kasamatsu, Tetsuhiro, additional, Minato, Yusuke, additional, Shimizu, Hiroaki, additional, Ishizaki, Takuma, additional, Yokohama, Akihiko, additional, Takizawa, Makiko, additional, Koiso, Hiromi, additional, Mitsui, Takeki, additional, Tsukamoto, Norifumi, additional, Handa, Hiroshi, additional, and Murakami, Hirokazu, additional

Published
2015
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44. Assessment of in vitro effects of direct thrombin inhibitors and activated factor X inhibitors through clot waveform analysis

Author

Wakui, Masatoshi, Fujimori, Yuta, Katagiri, Hisako, Nakamura, Shoko, Kondo, Yoshino, Kuroda, Yuko, Nakagawa, Terumichi, Shimizu, Nobuko, and Murata, Mitsuru

Abstract

AimsClot waveform analysis (CWA) has been reported to extend the interpretation of clotting time measurement. The parameters obtained from successive derivatives of the clotting reaction curves reflect the rates of activation of individual coagulation factors, theoretically dissecting the cascade pathway. This study aims to assess the in vitro effects of direct thrombin inhibitors (DTIs) and activated factor X (FXa) inhibitors.MethodsCWA was applied to the activated partial thromboplastin time (APTT) assay of plasma samples spiked with each drug. For CWA of APTT measurement curves (APTT-CWA), the positive mode of clotting reaction curves was defined as the direction towards fibrin generation.ResultsAll the maximum positive values in the successive derivatives were decreased dependently on the concentrations of each drug. Moreover, the negative values in the second and third derivatives appeared putatively due to consumption of thrombin and factor FXa, respectively, to form complexes with plasma serine protease inhibitors. The decrease of the maximum negative values observed dependently on the concentrations of each drug appeared to be consistent with the decreased generation of thrombin and factor FXa. The analysis of Hill coefficients of each drug in the dose–response of changes in the APTT-CWA parameters revealed a difference in anticoagulant cooperativity between DTIs versus FXa inhibitors.ConclusionsThe APTT-CWA demonstrated evidence for the blockade of thrombin-positive feedback by DTIs and FXa inhibitors and that for the differences in anticoagulant cooperativity between them. The results demonstrate the usability of CWA for assessment of anticoagulation and provide insights into direct anticoagulants.

Published
2019
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46. Pharmacokinetics and skin-tissue penetration of daptomycin in rats

Author

Matsumoto, Kazuaki, primary, Kitaoka, Masashi, additional, Kuroda, Yuko, additional, Ikawa, Kazuro, additional, Morikawa, Norifumi, additional, Sasaki, Junichi, additional, Iketani, Osamu, additional, Iwata, Satoshi, additional, Horino, Tetsuya, additional, Hori, Seiji, additional, and Kizu, Junko, additional

Published
2015
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50. BCL6 Dose Not Negatively Regulate DNA Damage Response Genes in Multiple Myeloma Cells

Author

Tahara, Kenichi, primary, Takizawa, Makiko, additional, Handa, Hiroshi, additional, Masuda, Yuta, additional, Kaneko, Ayaka, additional, Suda, Itsumi, additional, Kimura, Kei, additional, Kuroda, Yuko, additional, Atsushi, Isoda, additional, Matsumoto, Morio, additional, Koiso, Hiromi, additional, Takuma, Ishizaki, additional, Mitsui, Takeki, additional, Yokohama, Akihiko, additional, Saitoh, Takayuki, additional, Tsukamoto, Norifumi, additional, and Murakami, Hirokazu, additional

Published
2014
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