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A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one ( 1), together with four known compounds, 5,6-dehydrokawain ( 2), dihydro-5,6-dehydrokawain ( 3), (E)-labda-8(17),12-diene-15,16-dial ( 4), and quercetin ( 5) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial ( 4) and quercetin ( 5) exhibited potent inhibition, with IC values of 3.18 ± 1.13 and 1.17 ± 0.13 μg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O) generation. [ABSTRACT FROM AUTHOR]

A new aporphine alkaloid, (+)-(6aR,7R)-7-hydroxy-N-butyrylcaaverine ( 1 ), has been isolated from the roots of Illigera luzonensis. The structure of the new compound 1 was determined through spectroscopic and MS analyses. [ABSTRACT FROM AUTHOR]

A new phosphorus-containing polycyclic bismaleimide resin (BMPI) was prepared by the reaction of bis(3-maleimidophenyl) methylphosphine oxide (BAMP) with benzene-1,2,4,5-tetracarboxylic dianhydride (BTD) and maleic anhydride (MA). BMPI was confirmed by infrared (IR), 1H- and 13C-NMR spectroscopies. Its thermal properties were carried out by a differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) that revealed that the polymers have excellent thermal properties in the high temperature region and a high char yield of up to 53∼65%. Furthermore, three conventional bismaleimide resins were prepared from different phosphorus-free bismaleimides for comparison, e.g. 4,4′-bismaleimidodiphenylmethane (BDM), 4,4′-bismaleimidodiphenylether (BDE), 4,4′-bismaleimidodiphenylsulfone (BDS). [ABSTRACT FROM AUTHOR]

Two new thymol (=5-methyl-2-(1-methylethyl)phenol) derivatives, 8,10-didehydro-9-(3-methylbutanoyl)thymol 3-O-tiglate (1) and 9-O-angeloyl-8-methoxythymol 3-O-isobutyrate (2), were isolated from the root of Eupatorium cannabinum ssp. asiaticum, together with six known compounds, 3-8. The structures of 1 and 2 were determined through extensive 1D/2D-NMR and MS analyses. Among the isolates, 9-acetoxy-8,10-epoxythymol 3-O-tiglate (3) was the most cytotoxic, with IC50 values of 0.02±0.01, 1.02±0.07, and 1.36±0.12 μg/ml, respectively, against DLD-1, CCRF-CEM, and HL-60 cell lines. In addition, 10-acetoxy-9-O-angeloyl-8-hydroxythymol (4) and eupatobenzofuran (6) exhibited cytotoxicities, with IC50 values of 1.14±0.16 and 2.63±0.22, and 7.63±0.94 and 2.31±0.14 μg/ml, respectively, against DLD-1 and CCRF-CEM cell lines., (Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.)

A new dihydroagarofuran-based sesquiterpene, microjaponin (1), was isolated from the stem of Microtropis japonica. Its structure was determined by in-depth spectroscopic and mass-spectrometric analyses. Microjaponin (1) exhibited potent in vitro antituberculosis activity, with an MIC value of 12.5 μg/ml against Mycobacterium tuberculosis H37 Rv., (Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.)