A New 2 H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet.

A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one ( 1), together with four known compounds, 5,6-dehydrokawain ( 2), dihydro-5,6-dehydrokawain ( 3), (E)-labda-8(17),12-diene-15,16-dial ( 4), and quercetin ( 5) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial ( 4) and quercetin ( 5) exhibited potent inhibition, with IC values of 3.18 ± 1.13 and 1.17 ± 0.13 μg/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O) generation. [ABSTRACT FROM AUTHOR]