157 results on '"Kunze, Kent L."'
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2. N-Methylprotoporphyrin IX: Chemical Synthesis and Identification as the Green Pigment Produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine Treatment
3. Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations
4. Cooperative binding of midazolam with testosterone and alpha-napthoflavone within the CYP3A4 active site: A NMR T(sub 1) paramagnetic relaxation study
5. Sites of covalent attachment of CYP4 enzymes to heme: Evidence for microheterogeneity of P450 heme orientation
6. Persistent Inhibition of CYP3A4 by Ketoconazole in Modified Caco-2 Cells
7. Covalent linkage of prosthetic heme to CYP4 family P450 enzymes
8. Mechanism-based inactivation of human cytochrome P450 1A2 by furafylline: detection of a 1:1 adduct to protein and evidence for the formation of a novel imidazomethide intermediate
9. Fluvoxamine–theophylline interaction: Gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2
10. Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: In vitro and in vivo comparison and calculation of in vivo inhibition constants
11. First-pass metabolism of midazolam by the human intestine
12. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism
13. Mechanism of formation of the ester linkage between heme and glu310 of CYP4B1: [super 18]O protein labeling studies
14. Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate
15. EXOGENOUS HEME FUNCTIONALLY RECONSTITUTES HEPATIC CYTOCHROME P-450 IN VIVO
16. Characterization of Ritonavir-Mediated Inactivation of Cytochrome P450 3A4
17. Stereochemical evidence for decomposition of reactive intermediates by active site water in the metabolism of 8-alkyl xanthines by P450 1A2
18. Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy
19. Stereoselective Inhibition of CYP2C19 and CYP3A4 by Fluoxetine and Its Metabolite: Implications for Risk Assessment of Multiple Time-Dependent Inhibitor Systems
20. Risk Assessment of Mechanism-Based Inactivation in Drug-Drug Interactions
21. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
22. Allosteric Activation of Cytochrome P450 3A4 by α-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis
23. Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath test
24. Sequential Metabolism of Secondary Alkyl Amines to Metabolic-Intermediate Complexes: Opposing Roles for the Secondary Hydroxylamine and Primary Amine Metabolites of Desipramine, (S)-Fluoxetine, and N-Desmethyldiltiazem
25. Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: 18O Protein Labeling Studies
26. Sequential Metabolism Is Responsible for Diltiazem-Induced Time-Dependent Loss of CYP3A
27. STEREOCHEMICAL ASPECTS OF ITRACONAZOLE METABOLISM IN VITRO AND IN VIVO
28. Cooperative Binding of Midazolam with Testosterone and α-Naphthoflavone within the CYP3A4 Active Site: A NMR T1 Paramagnetic Relaxation Study
29. EVALUATION OF TIME-DEPENDENT INACTIVATION OF CYP3A IN CRYOPRESERVED HUMAN HEPATOCYTES
30. DIFFERENCES IN THE INHIBITION OF CYTOCHROMES P450 3A4 AND 3A5 BY METABOLITE-INHIBITOR COMPLEX-FORMING DRUGS
31. ROLE OF ITRACONAZOLE METABOLITES IN CYP3A4 INHIBITION
32. KIIV, AN IN VIVO PARAMETER FOR PREDICTING THE MAGNITUDE OF A DRUG INTERACTION ARISING FROM COMPETITIVE ENZYME INHIBITION
33. Comparison of In Vitro and In Vivo Inhibition Potencies of Fluvoxamine toward CYP2C19
34. Subnanomolar quantification of caffeine's in vitro metabolites by stable isotope dilution gas chromatography–mass spectrometry
35. The Role of Cytochrome P450 3A4 in Alfentanil Clearance
36. Relation Between Plasma and Saliva Concentrations of Enoxacin, Ciprofloxacin, and Theophylline
37. The Kinetics of Aflatoxin B1Oxidation by Human cDNA-Expressed and Human Liver Microsomal Cytochromes P450 1A2 and 3A4
38. Binding of the Aflatoxin-Glutathione Conjugate to Mouse Glutathione S-Transferase A3-3 Is Saturated at Only One Ligand per Dimer
39. Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity
40. Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
41. Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by Human CYP3A4
42. Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects
43. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
44. Metabolic enantiomeric interactions: The inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin
45. Mechanism of Formation of the Ester Linkage between Heme and Glu310 of CYP4B1: 18O Protein Labeling Studies.
46. Covalent Heme Binding to CYP4B1 via Glu310 and a Carbocation Porphyrin Intermediate.
47. Fluvoxamine-theophylline interaction: Gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2*.
48. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
49. Inhibition of ferrochelatase by N-methylprotoporphyrin IX is not accompanied by δ-aminolevulinic acid synthetase induction in chick embryo liver cell culture.
50. Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: In vitro and in vivo comparison and calculation of in vivo inhibition constants*.
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