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22 results on '"Kumar, Sanni"'

2. A Facile, Sensitive and Rapid Sensing Platform Based on CoZnO for Detection of Fipronil; an Environmental Toxin

Author

Kumar, Sanni, Vasylieva, Natalia, Singh, Vikrant, Hammock, Bruce, and Singh, Shiv Govind

Subjects
Analytical Chemistry, Chemical Sciences, Physical Chemistry, Bioengineering, Biosensors, Insecticides, Nanofibers, Physical Chemistry (incl. Structural), Other Chemical Sciences, Analytical chemistry, Physical chemistry
Abstract

A sensitive detection of extremely toxic phenylpyrazole insecticide, 'Fipronil' is presented. Currently, the advancement of approaches for the detection of insecticides at low concentrations with less time is important for environmental safety assurance. Considering this fact, an effort has been made to develop an electrospun CoZnO nanofiber (NF) based label-free electrochemical system for the detection of fipronil. The CoZnO NF were characterized using different techniques including field emission scanning electron microscopy (FE-SEM), Energy Dispersive X-Ray Analysis (EDX), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and Raman Spectroscopy. Based on the experimental results, the proposed platform displayed a linear response for fipronil in the attogram/mL range despite the multiple interfering agents. The sensitivity of the device was found to be 3.99 Kῼ (g/ml)-1 cm-2. Limit of detection (LOD) and limit of quantification (LOQ) were calculated and found to be 112 ag mL-1 and 340 ag mL-1 respectively. Further, this proposed sensor will be implemented in the fields for the rapid and proficient detection of the real samples.

Published
2020

19. MODELLING OF NEXT ZEN MEMORY CELL USING LOW POWER CONSUMING HIGH SPEED NANO DEVICES

Author

Sanjay Bhadra, J. Gope, Gangesh Gulshan, and Kumar Sanni Sinha

Subjects
Very-large-scale integration, Engineering, Nano devices, SIMPLE (military communications protocol), business.industry, Hardware_PERFORMANCEANDRELIABILITY, Power (physics), Set (abstract data type), CMOS, Memory cell, Hardware_INTEGRATEDCIRCUITS, Electronic engineering, business, Hardware_LOGICDESIGN, Electronic circuit
Abstract

Hybrid SET-CMOS circuits which syndicate the assets of both the SET [Single Electron Transistor] and CMOS depicts highest possibilities to be incorporated in practical implementation for future low power VLSI/ULSI configurations. The proposed work is an attempt based on SET-CMOS hybrid circuit to realize the next gen simple Memory Cell. The authors adhered to MIB model for SET and BSIM4 model for CMOS in realizing the complex cell. The maneuver of the proposed circuit is verified subsequently in standard environment. The outcomes are in good trade off with the conventional statistics of existing memory cell.

Published
2015

22. Neutrophil Extracellular Traps: Formation and Involvement in Disease Progression.

Author

Kumar, Sanni, Gupta, Ena, Kaushik, Sanket, and Jyoti, Anupam

Subjects
*PHAGOCYTOSIS, *LEUCOCYTE elastase, *NEUTROPHILS, *NATURAL immunity, *DISEASE progression, *ANIMALS, *AUTOANTIBODIES, *AUTOIMMUNE diseases, *EXTRACELLULAR space, *IMMUNITY, *INFECTION, *INFLAMMATION, *ADULT respiratory distress syndrome
Abstract

Neutrophils are the forerunner in innate immunity by defending the host organisms against infectious pathogens. During such process, neutrophils reach the site of inflammation/infection and eliminate the pathogens by phagocytosis as well as by forming the neutrophil extracellular traps (NETs). NETs trap and eradicate a number of microbes including bacteria, fungi, protozoa, viruses. NETs consist of DNA which is decorated with histones and granular proteins such as neutrophil elastase (NE), gelatinase, myeloperoxidase. NETosis (a process of NETs formation) is also involved in many inflammatory and autoimmune disorders with a major contribution to acute respiratory distress syndrome, sepsis, cystic fibrosis, periodontitis. Hyper NETosis or ineffective clearance of NETs would likely increase the risk of auto-antibody generation against NETs components and contribution in auto-inflammatory diseases. The purpose of this review is intended to highlight the molecular mechanisms of NETosis and its antimicrobial effect. Furthermore, a current status of NETosis in the pathogenesis of inflammatory and autoimmune disorders has been reviewed for better understanding. [ABSTRACT FROM AUTHOR]

Published
2018

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