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10 results on '"Kruger, Thilo."'

1. Interactive implants: vision and challenges

Author

Kruger Thilo, Kneist Werner, Olze Heidi, Hoffmann Klaus-Peter, Ruta Marc, Droste Wiebke, Rupp Rudiger, and Publica

Subjects
03 medical and health sciences, 0302 clinical medicine, Computer science, 020208 electrical & electronic engineering, 0202 electrical engineering, electronic engineering, information engineering, Biomedical Engineering, Medicine, 030211 gastroenterology & hepatology, 02 engineering and technology, humanimplant interaction, implant network, interactive implants
Abstract

Different complex physiological functions might be restored by means of distributed active implants. Wireless communication between the implants, on the one hand, and an external control unit, on the other hand, is necessary to synchronize electrical stimulation of neural and muscular tissue. Seventeen project partners from industries, universities, healthcare providers and research organizations closely cooperate in the framework of the BMBF Innovation Cluster “Interactive Implants (INTAKT)”. The goal of this cluster is to develop and evaluate networks of distributed implants. Challenges of the project include complex interaction between humans and technology, wireless power supply, long-term stability of implants as well as secure and safe signal transmission [1].

Published
2018
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3. Technical, Medical and Ethical Challenges in Networks of Smart Active Implants

Author

Hoffmann, Klaus-Peter, primary, Olze, Heidi, additional, Kneist, Werner, additional, Schiemer, Jonas Friedrich, additional, Kruger, Thilo, additional, Somerlik-Fuchs, Karin H, additional, Gottschalk, Michael, additional, Kostelnik, Jan, additional, Schreivogel, Alina, additional, Ruff, Roman, additional, Droste, Wiebke, additional, and Rupp, Rudiger, additional

Published
2019
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6. Measuring epileptogenicity in kainic acid injected rats

Author

Somerlik, Karin H., primary, Cosandier-Rimele, Delphine, additional, Cordeiro, Joacir G., additional, Kruger, Thilo B., additional, Mattmuller, Rudi, additional, Stieglitz, Thomas, additional, Aertsen, Ad, additional, and Schulze-Bonhage, Andreas, additional

Published
2011
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7. Calcifediol – More than the Stepchild of CKD-MBD Therapy?

Author

M. Brandenburg, Vincent and Kruger, Thilo

Abstract

In patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), 25OH-vitamin D (calcidiol) deficiency or insufficiency is a common finding with high prevalence. Numerous epidemiological studies have found an independent association of low levels of calcidiol with increased morbidity and mortality. Within different patient cohorts, application of cholecalciferol or ergocalciferol (native vitamin D) as well as calcifediol can help replenish vitamin D levels in patients with and without renal disease. However, it is unclear if such an approach is effective in modifying relevant clinical end-points. Currently available data are insufficient to clearly define situations in which calcifediol therapy might be superior to ergocalciferol or cholecalciferol therapy in terms of increasing calcidiol levels in CKD / ESRD. Similar to ergocalciferol or cholecalciferol application, also calcifediol therapy needs to undergo testing in randomized, controlled trials (RCT) in severe CKD or ESRD with reasonable end-points before recommendations about therapy can be established.

Published
2014

8. Rule-Based Modelling and Simulation of Drug-Administration Policies

Author

Bortolussi, L., Krüger, T., Thorsten Lehr, Wolf, V., K. Rupp, W. Thacker, L. T. Watson, M. Sosonkina, Bortolussi, Luca, Kruger, Thilo., Wolf, Verena, and Lehr, Thorsten

Subjects
time-inhomogeneous models, drug design, Rule based modelling, stochastic simulation, time-inhomogeneous model
Abstract

We investigate a model of drug administration in the con- text of a plaque-formation process responsible of Alzheimer’s disease. This is a polymerisation process, best described by a rule-based model to counteract the intrinsic combinatorial explosion of the underlying re- action network. Furthermore, there is the additional complicancy of time- dependent rates, modelling the effect of drugs. In the paper, we provide a novel and efficient rejection-based simulation algorithm that samples exactly the trajectory space and apply it to study the efficacy of different drug administration policies.

Published
2015

9. Technical, Medical and Ethical Challenges in Networks of Smart Active Implants.

Author

Hoffmann KP, Ruff R, Droste W, Rupp R, Olze H, Kneist W, Schiemer JF, Kruger T, Somerlik-Fuchs KH, Gottschalk M, Kostelnik J, and Schreivogel A

Subjects
Electric Stimulation, Humans, Electric Power Supplies, Prostheses and Implants
Abstract

Networks of distributed interactive micro-implants could enhance the treatment of otoneurological conditions such as tinnitus or restore impaired complex physiological/ motor functions such as gastrointestinal motility or grasping. For this, an electrical stimulation of neural and muscular tissue is a key prerequisite. Challenges in the development of such interactive micro-implants are the complex human-machine interface, the wireless power supply, and the long-term stability of implants as well as secure and safe signal transmission. This paper addresses all these topics as well as the ethical, legal and social implications of smart implant networks in general. First achievements of the German innovation cluster INTAKT will be presented.

Published
2019
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10. Risk factors for cardiovascular calcifications in non-diabetic Caucasian haemodialysis patients.

Author

Schlieper G, Brandenburg V, Djuric Z, Damjanovic T, Markovic N, Schurgers L, Kruger T, Westenfeld R, Ackermann D, Haselhuhn A, Dimkovic S, Ketteler M, Floege J, and Dimkovic N

Subjects
Adult, Aged, Aged, 80 and over, Calcinosis ethnology, Cardiomyopathies ethnology, Female, Humans, Kidney Failure, Chronic ethnology, Kidney Failure, Chronic therapy, Male, Middle Aged, Multivariate Analysis, Renal Dialysis, Risk Factors, Calcinosis etiology, Cardiomyopathies etiology, Kidney Failure, Chronic complications, White People
Abstract

Background/aims: Dialysis patients display an increased mortality which is associated with cardiovascular calcifications. Diabetes mellitus and ethnicity are known factors that affect the extent of cardiovascular calcifications. However, most studies have investigated mixed cohorts with diabetics and/or mixed ethnicity., Methods: Cardiovascular calcifications were assessed in non-diabetic Caucasian haemodialysis patients by the semiquantitative Adragao calcification score (X-ray pelvis and hands) and a novel composite calcification score encompassing the Adragao score as well as calcifications detected by X-ray of the fistula arm, echocardiography of heart valves and carotid ultrasound., Results: Using multivariate analysis, age, male gender, dialysis vintage, lower Kt/V, calcium-phosphate product, smoking and high-sensitivity CRP were independent risk factors for cardiovascular calcifications as assessed by the Adragao or the composite score. Pulse wave velocity was independently related to both calcification scores. Body mass index, cholesterol, triglycerides, iPTH and serum levels of fetuin-A and uncarboxylated matrix Gla protein were not associated with cardiovascular calcifications., Conclusions: In our cohort of non-diabetic Caucasian haemodialysis patients, age, male gender, dialysis vintage, smoking, calcium-phosphate product, high-sensitivity CRP and lower Kt/V were independent risk factors for cardiovascular calcifications. Whether lowering the calcium-phosphate product and increasing dialysis efficiency can reduce cardiovascular calcifications in dialysis patients remains to be determined., (Copyright (c) 2009 S. Karger AG, Basel.)

Published
2009
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