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Rule-Based Modelling and Simulation of Drug-Administration Policies
- Source :
- Scopus-Elsevier
- Publication Year :
- 2015
- Publisher :
- Society for Modeling and Simulation International, 2015.
-
Abstract
- We investigate a model of drug administration in the con- text of a plaque-formation process responsible of Alzheimer’s disease. This is a polymerisation process, best described by a rule-based model to counteract the intrinsic combinatorial explosion of the underlying re- action network. Furthermore, there is the additional complicancy of time- dependent rates, modelling the effect of drugs. In the paper, we provide a novel and efficient rejection-based simulation algorithm that samples exactly the trajectory space and apply it to study the efficacy of different drug administration policies.
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.dedup.wf.001..173c6657e9458bf200a9e40dba2ee465