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Your search keyword '"Krauss, Nancy E."' showing total 16 results
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16 results on '"Krauss, Nancy E."'

1. The Pinene Path to Taxanes

Author

Wender, Paul A., primary, Badham, Neil F., additional, Conway, Simon P., additional, Floreancig, Paul E., additional, Glass, Timothy E., additional, Houze, Jonathan B., additional, Krauss, Nancy E., additional, Lee, Daesung, additional, Marquess, Daniel G., additional, McGrane, Paul L., additional, Meng, Wei, additional, Mucciaro, Thomas P., additional, Mühlebach, Michel, additional, Natchus, Michael G., additional, Ohkuma, Takeshi, additional, Peschke, Bernd, additional, Rawlins, David B., additional, Shuker, Anthony J., additional, Sutton, Jim C., additional, Taylor, Richard E., additional, Tomooka, Katsuhiko, additional, and Wessjohann, Ludger A., additional

Published
1994
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3. A concise stereocontrolled synthesis of taxol

Author

Wender, Paul A., Badham, Neil F., Conway, Simon P., Floreancig, Paul E., Glass, Timothy E., Houze, Jonathan B., Krauss, Nancy E., Lee, Daesung, Marquess, Daniel G., McGrane, Paul L., Meng, Wei, Natchus, Michael G., Shuker, Anthony J., Sutton, James C., and Taylor, Richard E.

Subjects
Taxol -- Research, Enantiomers -- Analysis, Chemotherapy -- Research, Chemistry
Abstract

A novel 37-step procedure for the elaboration of taxanes was developed. The method utilizes pinene which provides the complete A- and B-ring fragments and an aldol closure which establishes the C-ring. The technique results to the formation of taxol in the correct enantiomeric form with the use of verbenone, the air-oxidation product of pinene as the starting material. The new method is the shortest one available to date which offers the advantage of giving more concise access to key analogues.

Published
1997

4. Approaches to taxol and taxol analogs through elaboration of aromatic C-ring precursors

Author

Wender, Paul A., Glass, Timothy E., Krauss, Nancy E., Muhlebach, Michel, Peschke, Bernd, and Rawlins, David B.

Subjects
Organic compounds -- Synthesis, Antineoplastic agents -- Research, Biological sciences, Chemistry
Abstract

A 21-step synthetic route to an enone known to be a taxoid precursor from pinene was developed as part of an effort to obtain access to the tricarbocyclic taxane core of taxol and its analogs via functionalization of its B and C rings. The procedure allows access to C1 oxidized intermediates, selective incorporation of substituents at C8 and oxidation at the C5 and C10 sites to afford 7-deoxy and 7,8-cyclopropyltaxol analogs.

Published
1996

8. The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol

Author

Wender, Paul A., primary, Badham, Neil F., additional, Conway, Simon P., additional, Floreancig, Paul E., additional, Glass, Timothy E., additional, Houze, Jonathan B., additional, Krauss, Nancy E., additional, Lee, Daesung, additional, Marquess, Daniel G., additional, McGrane, Paul L., additional, Meng, Wei, additional, Natchus, Michael G., additional, Shuker, Anthony J., additional, Sutton, James C., additional, and Taylor, Richard E., additional

Published
1997
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15. Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. An efficient solid-phase synthesis of olomoucine

Author

Hammarstro¨m, Lars G. J., Smith, David B., Talama´s, Francisco X., Labadie, Sharada S., and Krauss, Nancy E.

Abstract

4,6-Dichloro-2-(methylthio)-5-nitropyrimidine has been utilized as a building block for an efficient nine-step synthesis of olomoucine. The methodology reported herein is applicable to the regiocontrolled solution and solid-phase synthesis of libraries of highly substituted purines, as well as other related scaffolds.

Published
2002
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16. 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists

Author

Zhao, Shu-Hai, Berger, Jacob, Clark, Robin D., Sethofer, Steven G., Krauss, Nancy E., Brothers, Julie M., Martin, Renee S., Misner, Dinah L., Schwab, Dietmar, and Alexandrova, Ludmila

Subjects
*CHEMICAL inhibitors, *ORGANIC compounds, *CARBON compounds, *BENZENE
Abstract

Abstract: A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT6 receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT6 receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed. [Copyright &y& Elsevier]

Published
2007
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