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3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2007, Vol. 17 Issue 12, p3504-3507. 4p. - Publication Year :
- 2007
-
Abstract
- Abstract: A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT6 receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT6 receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed. [Copyright &y& Elsevier]
- Subjects :
- *CHEMICAL inhibitors
*ORGANIC compounds
*CARBON compounds
*BENZENE
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 25342271
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.12.093