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538 results on '"Krane, M"'

1. Effect of Composition on Microstructural Evolution during Homogenization of 7XXX Alloys

Author

Priya, Pikee, Sun, Yiwei, Johnson, D. R., Trumble, K. P., and Krane, M. J. M.

Subjects
Condensed Matter - Materials Science, 74N25, G.0
Abstract

The effect of composition on microstructure both at the length scale of the secondary dendrite arm spacing and nano-sized dispersoids during homogenization of Al-Zn-Cu-Mg-Zr alloys has been studied. A comprehensive model that can predict the microstructure at both the length scales has been used for the study. The microstructure predicted has been compared to that for two homogenized samples from a directionally solidified AA7050 sample and a reasonable match has been found. The initial as-cast microstructure for different compositions is calculated using Scheil type solidification from Thermo-Calc. The initial microstructure has a considerable influence on microstructural evolution during homogenization. To take advantage of the decreased solid solubility of Zr in {\alpha}-fcc, cooling rates during solidification must be high enough to prevent precipitation of primary Al3Zr. Under solidification with industrial cooling conditions solute rich alloys leads to fewer dispersoids. Based on the study, an improved composition range of 6-8%Zn, 1-2%Cu, 1-2%Mg and 0.1-0.15%Zr for 7XXX alloys has been proposed., Comment: 23 pages, 8 figures, Part of PhD Dissertation work by Pikee Priya at Purdue University (2016)

Published
2023

2. Radial Variation of Microstructure in a Direct-Chill Cast AA7050 Billet on Homogenization

Author

Priya, Pikee, Fezi, Kyle, Johnson, D. R., and Krane, M. J. M.

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science, 74N25, G.0
Abstract

A "through-process" solidification homogenization numerical model to study the microstructural evolution has been developed for AA7050 alloy. A continuum scale Direct Chill Casting (DCC) solidification model has been coupled with a meso-scale homogenization precipitation model to evaluate the radial variation of microstructure in a cylindrical DC cast billet after homogenization. The Local Solidification Times predicted by the DCC numerical model is used to predict the Secondary Dendritic Arm Spacing (SDAS) across the radius from an empirical relationship. It also predicts the macrosegregation used to estimate the radial as-cast microstructures (phases and phase fractions) using Thermo-Calc. Macrosegregation affects the initial and homogenized microstructures across the radius, making the surface prone to recrystallization, due to lesser dispersoids and larger precipitated particles during cooling, caused by lesser extent of Zenner pinning and Particle Stimulated Nucleation (PSN) of recrystallized grains respectively., Comment: 20 Pages, 8 Figures, part of the PhD Dissertation work by Pikee Priya at Purdue University (2016). Cited for reference

Published
2023

3. Multiscale prediction of microstructure length scales in metallic alloy casting

Author

Bellón, B., Boukellal, A. K., Isensee, T., Wellborn, O. M., Trumble, K. P., Krane, M. J. M., Titus, M. S., Tourret, D., and LLorca, J.

Subjects
Condensed Matter - Materials Science
Abstract

In this article, we combine casting experiments and quantitative simulations to present a novel multiscale modeling approach to predict local primary dendritic spacings in metallic alloys solidified in conditions relevant to industrial casting processes. To this end, primary dendritic spacings were measured in instrumented casting experiments in Al-Cu alloys containing 1\,wt\% and 4\,wt\% of Cu, and they were compared to spacing stability ranges and average spacings in dendritic arrays simulated using phase-field (PF) and dendritic needle network (DNN) models. It is first shown that PF and DNN lead to similar results for the Al-1\,wt\%Cu alloy, using a dendrite tip selection constant calculated with PF in the DNN simulations. PF simulations cannot achieve quantitative predictions for the Al-4\,wt\%Cu alloy because they are too computationally demanding due to the large separation of scale between tip radius and diffusion length, a characteristic feature of non-dilute alloys. Nevertheless, the results of DNN simulations for non-dilute Al-Cu alloys are in overall good agreement with our experimental results as well as with those of an extensive literature review. Simulations consistently suggest a widening of the PDAS stability range with a decrease of the temperature gradient as the microstructure goes from cellular-dendrites to well-developed hierarchical dendrites.

Published
2021

7. Scaling Analysis of Alloy Solidification and Fluid Flow in a Rectangular Cavity

Author

Plotkowski, A., Fezi, K., Krane, M. J. M., Nastac, Laurentiu, editor, Liu, Baicheng, editor, Fredriksson, Hasse, editor, Lacaze, Jacques, editor, Hong, Chun-Pyo, editor, Catalina, Adrian V., editor, Buhrig-Polaczek, Andreas, editor, Monroe, Charles, editor, Sabau, Adrian S., editor, Ruxanda, Roxana Elena Ligia, editor, Luo, Alan, editor, Sen, Subhayu, editor, and Diószegi, Attila, editor

Published
2016
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8. Aortic Valve Neocuspidization for Younger Patients - Safe and Feasible?

Author

Prinzing, A., Böhm, J., Schreyer, J., Burri, M., Lange, R., and Krane, M.

Subjects
AORTIC valve, AORTIC stenosis, AORTIC valve diseases, BIOPROSTHETIC heart valves, MITRAL valve
Abstract

This article discusses the outcomes of a surgical treatment option called aortic valve neocuspidization (AVNeo) with autologous pericardium for aortic valve disease in younger patients. The study analyzed the survival rates, freedom from reoperation, and valve-related events in 162 patients who underwent AVNeo. The results showed low pressure gradients after the surgery and throughout the study period, with excellent survival rates. The main reason for reoperation was endocarditis, while rates for structural valve degeneration were low. [Extracted from the article]

Published
2024
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9. Biological or Mechanical Mitral Valve? Long-Term Outcomes Following Mitral Valve Replacement in Two Essential Subgroups: Patients Aged 50 to 69 and Females.

Author

Feirer, N., Buchner, A., Weber, M., Lang, M., Dzilic, E., Lange, R., Vitanova, K., and Krane, M.

Subjects
MITRAL valve, TRICUSPID valve, FEMALES, AORTIC valve, OLDER patients, TRICUSPID valve surgery
Abstract

This article examines the long-term outcomes of mitral valve replacement (MVR) in two specific patient subgroups: females and patients aged 50 to 69. The study included 1,670 patients who underwent biological MVR (bMVR) and 369 patients who underwent mechanical MVR (mMVR) between 2000 and 2020. The results showed that survival rates were comparable between the two groups over a 15-year period. However, the cumulative incidence of reoperation was significantly lower in the mMVR group compared to the bMVR group. The study also found that major complications such as bleeding, stroke, and myocardial infarction were rare in both groups. [Extracted from the article]

Published
2024
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10. RNAseq Analysis of Isogenic Human Induced Pluripotent Stem Cell Lines Reveals Differential Gene Expression Patterns during Differentiation of Human Heart Organoids Due to a Patient-Specific TBX5 Mutation.

Author

Lahm, H., Northoff, B.H., Reinsch, M., Mantani, A., Neb, I., Dzilic, E., Doppler, S., Lange, R., Holdt, L.M., Hansen, A., Krane, M., and Dreßen, M.

Subjects
PLURIPOTENT stem cells, GENE expression, GENE ontology, CELL lines, RNA sequencing, INDUCED pluripotent stem cells
Abstract

This article discusses the use of human induced pluripotent stem cells (iPSCs) to study the effects of a disease-causing TBX5 mutation on the development of human heart organoids (hHOs). The researchers compared isogenic iPSC lines with and without the TBX5 mutation and found that both lines were equally capable of generating hHOs. However, hHOs derived from iPSCs with the TBX5 mutation showed dysregulation in several essential pathways, including extracellular matrix organization and muscle structure development. This study demonstrates the potential of hHOs as a powerful tool for studying the effects of genetic mutations on early cardiac development. [Extracted from the article]

Published
2024
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11. Single Cell Landscape of Epicardial Adipose Tissue in Patients with Coronary Artery Disease.

Author

Puluca, N., Wirth, F., Reiter, A., Prinzing, A., Lahm, H., Lange, R., Dreßen, M., Doppler, S., and Krane, M.

Subjects
EPICARDIAL adipose tissue, CORONARY artery disease, ADIPOSE tissue diseases, CORONARY artery bypass
Abstract

This article explores the cellular composition of epicardial adipose tissue (EAT) in patients with coronary artery disease (CAD) compared to non-CAD patients. The study used single nucleus RNA sequencing data from EAT samples and found that EAT is composed of adipocytes, macrophages, epicardial stromal cells, lymphocytes, endothelial cells, smooth muscle cells, and epicardial epithelial cells. CAD patients had more epicardial stromal cells and a trend towards fewer adipocytes. The study also found upregulation of inflammatory markers in several cell types within the CAD group, potentially contributing to disease progression. [Extracted from the article]

Published
2024
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12. Genome-Wide Association Study in 2,140 Patients and Subtype Meta-analyses of Barlow's Disease and Fibroelastic Deficiency Identify Novel Risk Loci for Mitral Valve Prolapse.

Author

Feirer, N., Weber, M., Knoll, K., Miranda, L., Yu, M., Lahm, H., Kameric, M., Doppler, S., Neb, I., Lichtner, P., Lek, M., Lange, R., Schunkert, H., Hagége, A., Bouatia-Naji, N., Müller-Myhsok, B., Trenkwalder, T., Gruber, P., Krane, M., and Dreßen, M.

Subjects
GENOME-wide association studies, MITRAL valve prolapse, LOCUS (Genetics), DEFICIENCY diseases, HEART valve diseases, MITRAL valve surgery
Abstract

This article discusses a genome-wide association study (GWAS) conducted on patients with mitral valve prolapse (MVP), a cardiac valve disease with a genetic component. The study aimed to identify genetic variants associated with MVP, specifically focusing on the subtypes fibroelastic deficiency (FED) and Barlow's Disease (BD). The cohort included 2,140 MVP patients, and the GWAS identified 40 loci associated with MVP. Subgroup analyses revealed two loci associated with FED and eight highly significant SNPs associated with BD. These findings may contribute to the development of personalized therapeutic approaches for MVP patients. [Extracted from the article]

Published
2024
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13. Beyond 10 Years—The Impact of Patient-Prosthesis Mismatch on Long-Term Survival and Reoperation Rates.

Author

Graser, M., Bleiziffer, S., Zittermann, A., Mayr, B., Puluca, N., Krane, M., and Prinzing, A.

Subjects
SURVIVAL rate, AORTIC valve transplantation
Abstract

This article, published in the journal Thoracic & Cardiovascular Surgeon, examines the impact of patient-prosthesis mismatch (PPM) on long-term survival and reoperation rates after valve replacement surgery. The study included 645 patients who underwent biological aortic valve replacement between 2000 and 2007. The incidence of PPM was determined based on echocardiographic examinations, and patient survival and reoperation status were analyzed during a mean follow-up of 12.5 years. The results showed that severe PPM was associated with impaired survival beyond 10 years, while higher age, arterial hypertension, and diabetes were significantly associated with overall mortality. However, there was no significant link between PPM and the rate of reintervention. [Extracted from the article]

Published
2024
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15. Generation of three CRISPR/Cas9 edited human induced pluripotent stem cell lines (DHMi005-A-5, DHMi005-A-6 and DHMi005-A-7) carrying a Holt-Oram Syndrome patient-specific TBX5 mutation with known cardiac phenotype and a FLAG-tag after exon 9 of the TBX5 gene

Author

Lahm, H., primary, Stieglbauer, S., additional, Neb, I., additional, Doppler, S., additional, Schneider, S., additional, Dzilic, E., additional, Lange, R., additional, Krane, M., additional, and Dreßen, M., additional

Published
2023
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21. Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome

Author

Krane, M, Dressen, M, Santamaria, G, My, I, Schneider, C, Dorn, T, Laue, S, Mastantuono, E, Berutti, R, Rawat, H, Gilsbach, R, Schneider, P, Lahm, H, Schwarz, S, Doppler, S, Paige, S, Puluca, N, Doll, S, Neb, I, Brade, T, Zhang, Z, Abou-Ajram, C, Northoff, B, Holdt, L, Sudhop, S, Sahara, M, Goedel, A, Dendorfer, A, Tjong, F, Rijlaarsdam, M, Cleuziou, J, Lang, N, Kupatt, C, Bezzina, C, Lange, R, Bowles, N, Mann, M, Gelb, B, Crotti, L, Hein, L, Meitinger, T, Wu, S, Sinnecker, D, Gruber, P, Laugwitz, K, Moretti, A, Krane M., Dressen M., Santamaria G., My I., Schneider C. M., Dorn T., Laue S., Mastantuono E., Berutti R., Rawat H., Gilsbach R., Schneider P., Lahm H., Schwarz S., Doppler S. A., Paige S., Puluca N., Doll S., Neb I., Brade T., Zhang Z., Abou-Ajram C., Northoff B., Holdt L. M., Sudhop S., Sahara M., Goedel A., Dendorfer A., Tjong F. V. Y., Rijlaarsdam M. E., Cleuziou J., Lang N., Kupatt C., Bezzina C., Lange R., Bowles N. E., Mann M., Gelb B. D., Crotti L., Hein L., Meitinger T., Wu S., Sinnecker D., Gruber P. J., Laugwitz K. -L., Moretti A., Krane, M, Dressen, M, Santamaria, G, My, I, Schneider, C, Dorn, T, Laue, S, Mastantuono, E, Berutti, R, Rawat, H, Gilsbach, R, Schneider, P, Lahm, H, Schwarz, S, Doppler, S, Paige, S, Puluca, N, Doll, S, Neb, I, Brade, T, Zhang, Z, Abou-Ajram, C, Northoff, B, Holdt, L, Sudhop, S, Sahara, M, Goedel, A, Dendorfer, A, Tjong, F, Rijlaarsdam, M, Cleuziou, J, Lang, N, Kupatt, C, Bezzina, C, Lange, R, Bowles, N, Mann, M, Gelb, B, Crotti, L, Hein, L, Meitinger, T, Wu, S, Sinnecker, D, Gruber, P, Laugwitz, K, Moretti, A, Krane M., Dressen M., Santamaria G., My I., Schneider C. M., Dorn T., Laue S., Mastantuono E., Berutti R., Rawat H., Gilsbach R., Schneider P., Lahm H., Schwarz S., Doppler S. A., Paige S., Puluca N., Doll S., Neb I., Brade T., Zhang Z., Abou-Ajram C., Northoff B., Holdt L. M., Sudhop S., Sahara M., Goedel A., Dendorfer A., Tjong F. V. Y., Rijlaarsdam M. E., Cleuziou J., Lang N., Kupatt C., Bezzina C., Lange R., Bowles N. E., Mann M., Gelb B. D., Crotti L., Hein L., Meitinger T., Wu S., Sinnecker D., Gruber P. J., Laugwitz K. -L., and Moretti A.

Abstract

BACKGROUND: Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrum of left ventricular outflow tract obstruction defects occurring in association with ventricular hypoplasia. The pathogenesis of HLHS is unknown, but hemodynamic disturbances are assumed to play a prominent role. METHODS: To identify perturbations in gene programs controlling ventricular muscle lineage development in HLHS, we performed whole-exome sequencing of 87 HLHS parent-offspring trios, nuclear transcriptomics of cardiomyocytes from ventricles of 4 patients with HLHS and 15 controls at different stages of heart development, single cell RNA sequencing, and 3D modeling in induced pluripotent stem cells from 3 patients with HLHS and 3 controls. RESULTS: Gene set enrichment and protein network analyses of damaging de novo mutations and dysregulated genes from ventricles of patients with HLHS suggested alterations in specific gene programs and cellular processes critical during fetal ventricular cardiogenesis, including cell cycle and cardiomyocyte maturation. Single-cell and 3D modeling with induced pluripotent stem cells demonstrated intrinsic defects in the cell cycle/unfolded protein response/autophagy hub resulting in disrupted differentiation of early cardiac progenitor lineages leading to defective cardiomyocyte subtype differentiation/ maturation in HLHS. Premature cell cycle exit of ventricular cardiomyocytes from patients with HLHS prevented normal tissue responses to developmental signals for growth, leading to multinucleation/polyploidy, accumulation of DNA damage, and exacerbated apoptosis, all potential drivers of left ventricular hypoplasia in absence of hemodynamic cues. CONCLUSIONS: Our results highlight that despite genetic heterogeneity in HLHS, many mutations converge on sequential cellular processes primarily driving cardiac myogenesis, suggesting n

Published
2021

30. Surgical Explantation After TAVR Failure: Mid-Term Outcomes From the EXPLANT-TAVR International Registry

Author

Bapat, V. N., Zaid, S., Fukuhara, S., Saha, S., Vitanova, K., Kiefer, P., Squiers, J. J., Voisine, P., Pirelli, L., von Ballmoos, M. W., Chu, M. W. A., Rodes-Cabau, J., Dimaio, J. M., Borger, M. A., Lange, R., Hagl, C., Denti, P., Modine, T., Kaneko, T., Tang, G. H. L., Sengupta, A., Holzhey, D., Noack, T., Harrington, K. B., Mohammadi, S., Brinster, D. R., Atkins, M. D., Algadheeb, M., Bagur, R., Desai, N. D., Bhadra, O. D., Conradi, L., Shults, C., Satler, L. F., Ramlawi, B., Robinson, N. B., Wang, L., Petrossian, G. A., Andreas, M., Werner, P., Garatti, A., Vincent, F., Van Belle, E., Juthier, F., Leroux, L., Doty, J. R., Goldberg, J. B., Ahmad, H. A., Goel, K., Shah, A. S., Geirsson, A., Forrest, J. K., Grubb, K. J., Hirji, S., Shah, P. B., Bruschi, G., Gelpi, G., Belluschi, I., Ouzounian, M., Ruel, M., Al-Atassi, T., Kempfert, J., Unbehaun, A., Van Mieghem, N. M., Hokken, T. W., Ben Ali, W., Ibrahim, R., Demers, P., Pizano, A., Di Eusanio, M., Capestro, F., Estevez-Loureiro, R., Pinon, M. A., Salinger, M. H., Rovin, J., D'Onofrio, A., Tessari, C., Di Virgilio, A., Taramasso, M., Gennari, M., Colli, A., Whisenant, B. K., Nazif, T. M., Kleiman, N. S., Szerlip, M. Y., Waksman, R., George, I., Nguyen, T. C., Maisano, F., Deeb, G. M., Bavaria, J. E., Reardon, M. J., Mack, M. J., Brinkman, W. T., George, T. J., Potluri, S., Ryan, W. H., Schaffer, J. M., Smith, R. L., Szerlip, M., Nazif, T., Rahim, H., Grubb, K., Atkins, M., Goel, S., Kleiman, N., Reardon, M., Doty, J., Whisenant, B., Salinger, M., Satler, L., Schults, C., Fisher, S., Alexis, S. L., Kliger, C. A., Rutkin, B., P. -J., Yu, Petrossian, G., Robinson, N., Deeb, M., Oakley, J., Bavaria, J., Desai, N., Walsh, L., Nguyen, T., Ahmad, H., Goldberg, J., Spielvogel, D., Forrest, J., Chu, M., Cartier, R., Abois, A. -P., Boodhwani, M., Dick, A., Glover, C., Labinaz, M., Lam, B. -K., Delhaye, C., Delsaux, A., Denimal, T., Gaul, A., Koussa, M., Pamart, T., Sonnabend, S., Krane, M., Munsterer, A., Bhadra, O., Merlanti, B., Russo, C. F., Romagnoni, C., and Pinnon, M.

Subjects
TAVR explantation, TAVR failure, surgical aortic valve replacement, transcatheter aortic valve replacement
Published
2021

31. Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner

Author

Querdel, Eva, primary, Reinsch, Marina, additional, Castro, Liesa, additional, Köse, Deniz, additional, Bähr, Andrea, additional, Reich, Svenja, additional, Geertz, Birgit, additional, Ulmer, Bärbel, additional, Schulze, Mirja, additional, Lemoine, Marc D., additional, Krause, Tobias, additional, Lemme, Marta, additional, Sani, Jascha, additional, Shibamiya, Aya, additional, Stüdemann, Tim, additional, Köhne, Maria, additional, Bibra, Constantin von, additional, Hornaschewitz, Nadja, additional, Pecha, Simon, additional, Nejahsie, Yusuf, additional, Mannhardt, Ingra, additional, Christ, Torsten, additional, Reichenspurner, Hermann, additional, Hansen, Arne, additional, Klymiuk, Nikolai, additional, Krane, M., additional, Kupatt, C., additional, Eschenhagen, Thomas, additional, and Weinberger, Florian, additional

Published
2021
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34. Functional Analysis of Candidate Genes Associated with Congenital Heart Disease during Differentiation of Induced Pluripotent Stem Cells and in the Human Embryonic and Adult Heart at Single-Cell Resolution

Author

Lahm, H., additional, Wirth, F., additional, Dreßen, M., additional, Jia, M., additional, Puluca, N., additional, Cleuziou, J., additional, Doppler, S., additional, Lange, R., additional, Müller-Myhsok, B., additional, and Krane, M., additional

Published
2021
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