Single Cell Landscape of Epicardial Adipose Tissue in Patients with Coronary Artery Disease.

This article explores the cellular composition of epicardial adipose tissue (EAT) in patients with coronary artery disease (CAD) compared to non-CAD patients. The study used single nucleus RNA sequencing data from EAT samples and found that EAT is composed of adipocytes, macrophages, epicardial stromal cells, lymphocytes, endothelial cells, smooth muscle cells, and epicardial epithelial cells. CAD patients had more epicardial stromal cells and a trend towards fewer adipocytes. The study also found upregulation of inflammatory markers in several cell types within the CAD group, potentially contributing to disease progression. [Extracted from the article]