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2. Fetal MRI‐Based Body and Adiposity Quantification for Small for Gestational Age Perinatal Risk Stratification.

Author

Rabinowich, Aviad, Avisdris, Netanell, Yehuda, Bossmat, Zilberman, Ayala, Graziani, Tamir, Neeman, Bar, Specktor‐Fadida, Bella, Link‐Sourani, Dafna, Wexler, Yair, Herzlich, Jacky, Krajden Haratz, Karina, Joskowicz, Leo, Ben Sira, Liat, Hiersch, Liran, and Ben Bashat, Dafna

Subjects
SMALL for gestational age, BODY composition, OBESITY, FETAL growth retardation, FISHER exact test
Abstract

Background: Small for gestational age (SGA) fetuses are at risk for perinatal adverse outcomes. Fetal body composition reflects the fetal nutrition status and hold promise as potential prognostic indicator. MRI quantification of fetal anthropometrics may enhance SGA risk stratification. Hypothesis: Smaller, leaner fetuses are malnourished and will experience unfavorable outcomes. Study Type: Prospective. Population: 40 SGA fetuses, 26 (61.9%) females: 10/40 (25%) had obstetric interventions due to non‐reassuring fetal status (NRFS), and 17/40 (42.5%) experienced adverse neonatal events (CANO). Participants underwent MRI between gestational ages 30 + 2 and 37 + 2. Field Strength/Sequence: 3‐T, True Fast Imaging with Steady State Free Precession (TruFISP) and T1‐weighted two‐point Dixon (T1W Dixon) sequences. Assessment: Total body volume (TBV), fat signal fraction (FSF), and the fat‐to‐body volumes ratio (FBVR) were extracted from TruFISP and T1W Dixon images, and computed from automatic fetal body and subcutaneous fat segmentations by deep learning. Subjects were followed until hospital discharge, and obstetric interventions and neonatal adverse events were recorded. Statistical Tests: Univariate and multivariate logistic regressions for the association between TBV, FBVR, and FSF and interventions for NRFS and CANO. Fisher's exact test was used to measure the association between sonographic FGR criteria and perinatal outcomes. Sensitivity, specificity, positive and negative predictive values, and accuracy were calculated. A P‐value <0.05 was considered statistically significant. Results: FBVR (odds ratio [OR] 0.39, 95% confidence interval [CI] 0.2–0.76) and FSF (OR 0.95, CI 0.91–0.99) were linked with NRFS interventions. Furthermore, TBV (OR 0.69, CI 0.56–0.86) and FSF (OR 0.96, CI 0.93–0.99) were linked to CANO. The FBVR sensitivity/specificity for obstetric interventions was 85.7%/87.5%, and the TBV sensitivity/specificity for CANO was 82.35%/86.4%. The sonographic criteria sensitivity/specificity for obstetric interventions was 100%/33.3% and insignificant for CANO (P = 0.145). Data Conclusion: Reduced TBV and FBVR may be associated with higher rates of obstetric interventions for NRFS and CANO. Evidence Level: 2 Technical Efficacy: Stage 5 [ABSTRACT FROM AUTHOR]

Published
2024
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6. Subtle findings on fetal brain imaging in CMV infected pregnancies: What is the clinical significance? A retrospective analysis with outcome correlation

Author

Brusilov Michael, Winsteen Adi, Malinger Gustavo, Wolman Igal, Krajden Haratz Karina, Birnbaum Roee, and Ben-Sira Liat

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, 030105 genetics & heredity, Ultrasonography, Prenatal, White matter, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, False Positive Reactions, Cyst, Clinical significance, Pregnancy Complications, Infectious, Central Nervous System Cysts, Genetics (clinical), Retrospective Studies, Choroid plexus cyst, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, Obstetrics, business.industry, Basal Ganglia Cerebrovascular Disease, Infant, Newborn, Brain, Obstetrics and Gynecology, Retrospective cohort study, Magnetic resonance imaging, Prognosis, medicine.disease, Magnetic Resonance Imaging, White Matter, medicine.anatomical_structure, Cytomegalovirus Infections, Amniocentesis, Female, business, Hydrocephalus
Abstract

Objective To describe the prognosis of subtle findings on fetal brain imaging in pregnant women with primary CMV infection during pregnancy. Methods This was a retrospective study. The data included: timing of infection, amniocentesis results, imaging findings, obstetric outcome, and developmental assessment. Results For the 27 included patients, the time of infection was: periconception, first, second, third trimesters or unknown in 14.8%, 29.7%, 40.7%, 7.4%, and 7.4%, respectively. Seventy-four percent had only MRI findings; white matter hyperintense T2 signal (HT2) (51.8%), mild ventriculomegaly (18.5%), HT2 and temporal cyst (7.4%), dilated occipital horn (7.4%), Periventricular pseudo cyst (PVPC) with dilated occipital horn (3.7%), isolated PVPC (7.4%), choroid plexus cyst (3.7%). In 26% of fetuses, additional ultrasound findings were observed: Lenticulostriatal vasculopathy (LSV) (11.1%), LSV with PVPC (3.84%), isolated PVPC (3.84%), mild ventriculomegaly (3.84%), and bilateral temporal cysts (3.84%). In 66.6%, the MRI had false-positive findings (due to noninfected neonates). All children are developing normally, and one has a hearing deficit. Postnatal ultrasound (US) was normal in 21/27, with LSV in five, and a resolving subependymal cyst in one patient. Conclusion Subtle imaging findings are more common on MRI than US and the prognosis is most likely favorable. Performing amniocentesis will significantly reduce the false-positive rate.

Published
2020
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7. L1CAM variants cause two distinct imaging phenotypes on fetal MRI

Author

Accogli, Andrea, primary, Goergen, Stacy, additional, Izzo, Giana, additional, Mankad, Kshitij, additional, Krajden Haratz, Karina, additional, Parazzini, Cecilia, additional, Fahey, Michael, additional, Menzies, Lara, additional, Baptista, Julia, additional, Carpineta, Lucia, additional, Tortora, Domenico, additional, Fulcheri, Ezio, additional, Gaetano Vellone, Valerio, additional, Paladini, Dario, additional, Spaccini, Luigina, additional, Toto, Valentina, additional, Trayers, Claire, additional, Ben Sira, Liat, additional, Reches, Adi, additional, Malinger, Gustavo, additional, Salpietro, Vincenzo, additional, De Marco, Patrizia, additional, Srour, Myriam, additional, Zara, Federico, additional, Capra, Valeria, additional, Rossi, Andrea, additional, and Severino, Mariasavina, additional

Published
2021
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8. An international registry for emergent pathogens and pregnancy

Author

Alice Panchaud, Guillaume Favre, Leo Pomar, Manon Vouga, Karoline Aebi-Popp, David Baud, Tallarek Ann-Christin, Strizek Brigitte, Hecher Kurt, Böckenhoff Paul, Schrey-Petersen Susanne, Mullins Edward, Bromley Rebecca, Whitehead Clare, Rolnik Daniel, Deprest Jan, Richter Jute, Gomes Luz Adriana, Bohrer Betania, Carvalho Ribeiro-do-Valle Carolina, Garanhani Surita Fernanda, Schuler-Faccini Lavinia, Osorio Wender Maria Celeste, Da Rocha Oppermann Maria Lucia, Moreira de sa Renato Augusto, Quintana Silvana, Sjaus Ana, Rahman Arifa, Hamel-Thibault Audrey, Nash Christopher, Kakkar Fatima, Berger Howard, Boucoiran Isabelle, Pasquier Jean-Charles, Snelgrove John, Zipursky Jonathan, Lacroix Meagan, Whittle Wendy, Fuenzalida Javiera, Carvajal Jorge, Guerra Canales Manuel, Hernandez Olivia, Yin Mingzhu, Chen Xiang, Qi Xiaolong, Sanín Blair José Enrique, Gonzalez Ricardo, Cano Aguilar Africa, Rodriguez Vicente Agueda, Tubau Navarra Albert, Puertas Prieto Alberto, Cano Garcia Alejandra Maria, Carrascal Cumplido Ana, Villalba Yarza Ana, Filloy Lavia Ana Cristina, Fernandez Alonso Ana Maria, Sanchez Vegazo Garcia Angeles, Goncé Anna, Ruano Garcia Antonio, Sanchez Munoz Antonio, Marcos Puig Beatriz, Munoz Abellana Begona, Garrido Luque Belen, Fernandez Fernandez Camino, Larranaga Azcarate Carlos, Baena Luque Carmen, Orizales Lago Carmen Maria, Alvarez Colomo Cristina, Lesmes Heredia Cristina, Ruiz Aguilar Cristina, Ferriols Perez Elena, Pascual Salvador Elena, Carmona Sanchez Encarnacion, Alvarez Silvares Esther, Canedo Carballeira Esther Maria, Moran Antolin Eva, Muelas Parraga Eva Maria, Oviedo Perez Eva Maria, Gonzalez Carvajal Francisco Jesus, Agudo Iène, Ocerin Bengoa Iratxe, Gastaca Abasolo Irene, Cabello de Alba Fernandez Isabel, Alvarez Javier, Duro Gomez Jorge, Atxotegi Jose, Navarrina Martinez José, Ruiz Aragon José, Sainz Bueno José Antonio, Adanez Garcia Jose Manuel, Broullon Molanes José Roman, Wizner de Alva Juan Carlos, Forcen Acebal Laura, Gonzalez Rodriguez Laura, Aceituno Velasco Longinos, Cerrillos Gonzalez Lucas, Trigo Lucas, Diaz Meca Lucia, Parada Millan M Carmen, Molina Oller Magdalena, Dominguez Gonzalez Manuel, Munoz Chapuli Gutierrez Mar, Caridad Ortiz Herrera Maria, Nieves Quesada Fernandez Maria, Suarez Arana Maria, Teulon Gonzalez Maria, Zafra Bailera Maria, Duenas Carazo Maria Begona, Gonzalez Macias Maria Carmen, Pilar Guadix Martin Maria del, Barbancho Lopez Maria del Carmen, Medina Mallen Maria del Carmen, Pardo Pumar Maria Isabel, Gimeno Gimeno Maria Joaquina, Nunez Valera Maria José, Pelegay Escartin Maria José, Camacho Caro Marta, Garcia Sanchez Marta, Meca Casbas Marta Ruth, Fraca Padilla Mercedes, Ramirez Gomez Mercedes, Catalina Coello Monica, Cruz Lemini Monica, Perez Perez Noelia, Nieto Velasco Olga, Alomar Mateu Onofre, Martinez Perez Oscar, Vaquerizo Ruiz Oscar, Barrio Fernández Pablo Guillermo del, Monteliu Gonzalez Pilar, Prats Rodriguez Pilar, Vivaracho Terrer Porfirio, Gonzales Seoane Raquel, Jimenez Velazquez Raquel, Alvarez Fernandez Rebeca, Lopez Perez Rocio, Ostos Serna Rosa Maria, Redondo Aguilar Rosario, Bernardo Vega Rut, Cano Sandra, Mateos Lopez Silvia, Fernandez Garcia Susana, Soldevilla Perez Susana, Manrique Gomez Tania, Munoz Carmona Vitor, Ko Albert I, Johnson Anthony, Nielsen Saines Karin, Cambou Mary, Grechukhina Olga, Neupane Sahara, Reddy Uma, Shah Zubin, Breton Bénédicte, Garabedian Charles, Bertholdt Charline, Poncelet Christophe, Subtil Damien, Musso Didier, Henry Estelle, Plantefeve Gaetan, Ducarme Guillaume, Pelerin Helene, Dimet Jerome, Cottin Judith, Stiremann Julien, Lambert Véronique, Hcini Najeh, Salomon Laurent, Sentilhes Loïc, Giral Marylene, Mottet Nicolas, Morel Olivier, Rozenberg Patrick, Lucie Sedille, Quibel Thibaud, Karagianni Vasiliki, Equy Véronique, Ville Yves, Carles Gabriel, Ruehl Ina, Cleary Brian, Malone Fergal, Higgins Mary, Geary Michael, Hadar Eran, Malinger Gustavo, Sela Hen, Krajden Haratz Karina, Maymon Ron, Yogev Yariv, De Luca Carmen, De Santis Marco, Rosso Telefono, Atallah David, Boguziene Emilija, Germes Pina Fernando, Van den Akker Thomas, Gil-Guevara Enrique, Marchena Jeannette, Ventura Walter, Pereira Alcides, Ayres de Campos Diogo, Charepe Nadia, Viana Pinto Pedro, Ntasumbumuyange Diomede, Rulisa Stephen, Panchaud Alice, Radan Anda-Petronela, Papadia Andrea, Bloch Andrea, Feki Anis, Muller Brochut Anne-Claude, Toussaint Arnaud, Eggel-Hort Béatrice, Martinez de Tejada Begoña, Frey Tirri Brigitte, Weber Brigitte, Blume Carolin, Monod Cécile, Kahlert Christian, Voekt Cora, Surbek Daniel, Baud David, Bassler Dirk, Mueller Doris, Prentl Elke Barbara, Gerber Eva, Rothe Friederike, Eric Giannoni, Favre Guillaume, Hoesli Irene, Mathis Jérôme, Lepigeon Karine, Aebi-Popp Karoline, Pomar Leo, Schäffer Leonhard, Raio Luigi, Vouga Manon, Huesler Charles Margaret, Rossier Marie-Claude, Hodel Markus, Kaufmann Martin, Gavillet Mathilde, Boulvain Michel, Todesco Bernasconi Monya, Bickle Myriam, Ochsenbein Kölble Nicole, Jarrah Omar, Kanellos Panagiotis, Brasier Lutz Pascale, Capoccia Brugger Romina, Heldstab Sandra, Heldstab Sandra Andrea, Rouiller Cornu Sylvie, Fischer Tina, Winterfeld Ursula, Lambelet Valentine, Rieder Wawrzyniec, Greub Gilbert, Gengler Carole, Patel Rena C, Huespe Miguel Angel, Nieto-Calvache Albaro José, COVI-Preg group, Ann-Christin, T., Brigitte, S., Kurt, H., Paul, B., Susanne, S.P., Edward, M., Rebecca, B., Clare, W., Daniel, R., Jan, D., Jute, R., Adriana, G.L., Betania, B., Carolina, C.R., Fernanda, G.S., Lavinia, S.F., Maria Celeste, O.W., Maria Lucia, DRO, Renato Augusto, M.S., Silvana, Q., Ana, S., Arifa, R., Audrey, H.T., Christopher, N., Fatima, K., Howard, B., Isabelle, B., Jean-Charles, P., John, S., Jonathan, Z., Meagan, L., Wendy, W., Javiera, F., Jorge, C., Manuel, G.C., Olivia, H., Mingzhu, Y., Xiang, C., Xiaolong, Q., José Enrique, S.B., Ricardo, G., Africa, C.A., Agueda, R.V., Albert, T.N., Alberto, P.P., Alejandra Maria, C.G., Ana, C.C., Ana, V.Y., Ana Cristina, F.L., Ana Maria, F.A., Angeles, SVG, Anna, G., Antonio, R.G., Antonio, S.M., Beatriz, M.P., Begona, M.A., Belen, G.L., Camino, F.F., Carlos, L.A., Carmen, B.L., Carmen Maria, O.L., Cristina, A.C., Cristina, L.H., Cristina, R.A., Elena, F.P., Elena, P.S., Encarnacion, C.S., Esther, A.S., Esther Maria, C.C., Eva, M.A., Eva Maria, M.P., Eva Maria, O.P., Francisco Jesus, G.C., Iène, A., Iratxe, O.B., Irene, G.A., Isabel, CAF, Javier, A., Jorge, D.G., Jose, A., José, N.M., José, R.A., José Antonio, S.B., Jose Manuel, A.G., José Roman, B.M., Juan Carlos, W.A., Laura, F.A., Laura, G.R., Longinos, A.V., Lucas, C.G., Lucas, T., Lucia, D.M., M Carmen, P.M., Magdalena, M.O., Manuel, D.G., Mar, MCG, Maria, COH, Maria, NQF, Maria, S.A., Maria, T.G., Maria, Z.B., Maria Begona, D.C., Maria Carmen, G.M., Maria Del, PGM, Maria Del Carmen, B.L., Maria Del Carmen, M.M., Maria Isabel, P.P., Maria Joaquina, G.G., Maria José, N.V., Maria José, P.E., Marta, C.C., Marta, G.S., Marta Ruth, M.C., Mercedes, F.P., Mercedes, R.G., Monica, C.C., Monica, C.L., Noelia, P.P., Olga, N.V., Onofre, A.M., Oscar, M.P., Oscar, V.R., Pablo Guillermo Del, B.F., Pilar, M.G., Pilar, P.R., Porfirio, V.T., Raquel, G.S., Raquel, J.V., Rebeca, A.F., Rocio, L.P., Rosa Maria, O.S., Rosario, R.A., Rut, B.V., Sandra, C., Silvia, M.L., Susana, F.G., Susana, S.P., Tania, M.G., Vitor, M.C., Albert I, K., Anthony, J., Karin, N.S., Mary, C., Olga, G., Sahara, N., Uma, R., Zubin, S., Bénédicte, B., Charles, G., Charline, B., Christophe, P., Damien, S., Didier, M., Estelle, H., Gaetan, P., Guillaume, D., Helene, P., Jerome, D., Judith, C., Julien, S., Véronique, L., Najeh, H., Laurent, S., Loïc, S., Marylene, G., Nicolas, M., Olivier, M., Patrick, R., Sedille, L., Thibaud, Q., Vasiliki, K., Véronique, E., Yves, V., Gabriel, C., Ina, R., Brian, C., Fergal, M., Mary, H., Michael, G., Eran, H., Gustavo, M., Hen, S., Karina, K.H., Ron, M., Yariv, Y., Carmen, L., Marco, S., Telefono, R., David, A., Emilija, B., Fernando, G.P., Thomas, VDA, Enrique, G.G., Jeannette, M., Walter, V., Alcides, P., Diogo, A.C., Nadia, C., Pedro, V.P., Diomede, N., Stephen, R., Alice, P., Anda-Petronela, R., Andrea, P., Andrea, B., Anis, F., Anne-Claude, M.B., Arnaud, T., Béatrice, E.H., Begoña, M.T., Brigitte, F.T., Brigitte, W., Carolin, B., Cécile, M., Christian, K., Cora, V., Daniel, S., David, B., Dirk, B., Doris, M., Elke Barbara, P., Eva, G., Friederike, R., Giannoni, E., Guillaume, F., Irene, H., Jérôme, M., Karine, L., Karoline, A.P., Leo, P., Leonhard, S., Luigi, R., Manon, V., Margaret, H.C., Marie-Claude, R., Markus, H., Martin, K., Mathilde, G., Michel, B., Monya, T.B., Myriam, B., Nicole, O.K., Omar, J., Panagiotis, K., Pascale, B.L., Romina, C.B., Sandra, H., Sandra Andrea, H., Sylvie, R.C., Tina, F., Ursula, W., Valentine, L., Wawrzyniec, R., Gilbert, G., Carole, G., Rena C, P., Miguel Angel, H., and Albaro José, N.C.

Subjects
Diagnostic Screening Programs, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Severe Acute Respiratory Syndrome, Communicable Diseases, Emerging, Risk Assessment, Betacoronavirus, Fetus, Pregnancy, Risk Factors, Pandemic, medicine, Humans, Registries, 610 Medicine & health, Intensive care medicine, Pandemics, Zika Virus Infection, Viral Epidemiology, business.industry, Pregnancy Outcome, Betacoronavirus/growth & development, Betacoronavirus/immunology, Communicable Diseases, Emerging/epidemiology, Communicable Diseases, Emerging/prevention & control, Coronavirus Infections/epidemiology, Diagnostic Screening Programs/standards, Female, Interdisciplinary Placement/methods, Pneumonia, Viral/epidemiology, Pregnancy Outcome/epidemiology, Severe Acute Respiratory Syndrome/epidemiology, Zika Virus/immunology, Zika Virus Infection/epidemiology, COVID-19, Zika Virus, General Medicine, medicine.disease, Interdisciplinary Placement, sars-cov-2, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Coronavirus Infections, business
Published
2020

10. Maternal Outcomes and Risk Factors for Severity Among Pregnant Women With COVID-19: A Case Control Study From the COVI-Preg International Registry

Author

Vouga, Manon, primary, Favre, Guillaume, additional, Martinez Perez, Oscar, additional, Pomar, Leo, additional, Forcen Acebal, Laura, additional, Abascal, Alejandra, additional, Vila Hernandez, Maria Rosa, additional, Hcini, Najeh, additional, Lambert, Véronique, additional, Carles, Gabriel, additional, Sichitiu, Joanna, additional, Salomon, Laurent, additional, Stiremann, Julien, additional, Ville, Yves, additional, Martinez de Tejada, Begoña, additional, Goncé, Anna, additional, Hawkins-Villareal, Ameth, additional, Castillo, Karen, additional, Gratacos Solsona, Eduard, additional, Trigo, Lucas, additional, Cleary, Brian, additional, Geary, Michael, additional, Bartels, Helena, additional, Al-Kharouf, Feras, additional, Malone, Fergal, additional, Higgins, Mary, additional, Keating, Niamh, additional, Knowles, Susan, additional, Poncelet, Christophe, additional, Carvalho, Carolina, additional, Ribeiro-do-Valle, Fernanda, additional, Surita, Garanhani, additional, Dantas-Silva, Amanda, additional, Borrelli, Carolina, additional, Gomes Luz, Adriana, additional, Fuenzalida, Javiera, additional, Carvajal, Jorge, additional, Guerra Canales, Manuel, additional, Hernandez, Olivia, additional, Grechukhina, Olga, additional, Ko, Albert I., additional, Reddy, Uma, additional, Figueiredo, Rita, additional, Moucho, Marina, additional, Viana Pinto, Pedro, additional, De Luca, Carmen, additional, De Santis, Marco, additional, Ayres de Campos, Diogo, additional, Garabedian, Charles, additional, Subtil, Damien, additional, Bohrer, Betania, additional, Da Rocha Oppermann, Maria Lucia, additional, Celeste, Maria, additional, Wender, Osorio, additional, Schuler-Faccini, Lavinia, additional, Vieira Sanseverino, Maria Teresa, additional, Giugliani, Camila, additional, Friedrich, Luciana, additional, Horn Scherer, Mariana, additional, Mottet, Nicolas, additional, Ducarme, Guillaume, additional, Pelerin, Helene, additional, Moreau, Chloe, additional, Breton, Bénédicte, additional, Quibel, Thibaud, additional, Rozenberg, Patrick, additional, Mueller, Doris, additional, Granado, Cristina, additional, Hoesli, Irene, additional, Monod, Cécile, additional, Bassler, Dirk, additional, Heldstab, Sandra, additional, Ochsenbein Kölble, Nicole, additional, Sentilhes, Loïc, additional, Charvet, Melissa, additional, Deprest, Jan, additional, Richter, Jute, additional, Van der Veeken, Lennart, additional, Eggel-Hort, Béatrice, additional, Plantefeve, Gaetan, additional, Derouich, Mohamed, additional, Nieto Calvache, Albaro José, additional, Lopez-Giron, Maria Camila, additional, Burgos-Luna, Juan Manuel, additional, Escobar-Vidarte, Maria Fernanda, additional, Hecher, Kurt, additional, Tallarek, Ann-Christin, additional, Hadar, Eran, additional, Krajden Haratz, Karina, additional, Malinger, Gustavo, additional, Maymon, Ron, additional, Yogev, Yariv, additional, Schäffer, Leonhard, additional, Toussaint, Arnaud, additional, Rossier, Marie-Claude, additional, Moreira de sa, Renato Augusto, additional, Grawe, Claudia, additional, Aebi-Popp, Karoline, additional, Radan, Anda-Petronela, additional, Raio, Luigi, additional, Surbek, Daniel, additional, Böckenhoff, Paul, additional, Strizek, Brigitte, additional, Kaufmann, Martin, additional, Bloch, Andrea, additional, Boulvain, Michel, additional, Johann, Silke, additional, Heldstab, Sandra Andrea, additional, Todesco Bernasconi, Monya, additional, Grant, Gaston, additional, Feki, Anis, additional, Muller Brochut, Anne-Claude, additional, Giral, Marylene, additional, Sedille, Lucie, additional, Papadia, Andrea, additional, Capoccia Brugger, Romina, additional, Weber, Brigitte, additional, Fischer, Tina, additional, Kahlert, Christian, additional, Nielsen Saines, Karin, additional, Cambou, Mary, additional, Kanellos, Panagiotis, additional, Chen, Xiang, additional, Yin, Mingzhu, additional, Haessig, Annina, additional, Baud, David, additional, and Panchaud, Alice, additional

Published
2020
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11. Walker-Warburg syndrome and tectocerebellar dysraphia: A novel association caused by a homozygous DAG1 mutation

Author

Leibovitz, Zvi, primary, Mandel, Hanna, additional, Falik-Zaccai, Tzipora C., additional, Ben Harouch, Shani, additional, Savitzki, David, additional, Krajden-Haratz, Karina, additional, Gindes, Liat, additional, Tamarkin, Mordechai, additional, Lev, Dorit, additional, Dobyns, William B., additional, and Lerman-Sagie, Tally, additional

Published
2018
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12. Unique Imaging Features Enabling the Prenatal Diagnosis of Developmental Venous Anomalies: A Persistent Echogenic Brain Lesion Drained by a Collecting Vein in Contrast with Normal Brain Parenchyma on MRI

Author

Krajden Haratz, Karina, primary, Peled, Alon, additional, Weizman, Boris, additional, Gindes, Liat, additional, Tamarkin, Mordechai, additional, Lev, Dorit, additional, Kidron, Dvora, additional, Ben-Sira, Liat, additional, Malinger, Gustavo, additional, Lerman-Sagie, Tally, additional, and Leibovitz, Zvi, additional

Published
2017
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14. Unique Imaging Features Enabling the Prenatal Diagnosis of Developmental Venous Anomalies: A Persistent Echogenic Brain Lesion Drained by a Collecting Vein in Contrast with Normal Brain Parenchyma on MRI.

Author

Haratz, Karina Krajden, Peled, Alon, Weizman, Boris, Gindes, Liat, Tamarkin, Mordechai, Lev, Dorit, Kidron, Dvora, Ben-Sira, Liat, Malinger, Gustavo, Lerman-Sagie, Tally, Leibovitz, Zvi, and Krajden Haratz, Karina

Subjects
CHROMOSOMAL proteins, MAGNETIC resonance imaging, HUMAN abnormalities, CYSTIC fibrosis, FETAL brain abnormalities
Abstract

Objective: To describe the prenatal imaging features enabling diagnosis of developmental venous anomalies (DVA).Methods: Four fetuses with unexplained persistent echogenic parenchymal brain lesions were studied. The evaluation included dedicated neurosonography, fetal MRI, serology for intrauterine infection, screening for coagulation abnormalities, and chromosomal microarray. Postnatal neurodevelopmental follow-up or autopsy results were assessed.Results: DVA presented as very slowly growing echogenic brain lesions without cystic components, calcifications, or structural changes on otherwise normal neurosonographic scans performed at 2- to 3-week intervals. A specific Doppler feature was a collecting vein draining the echogenic parenchyma. Fetal brain MRI depicted normal anatomy on half-Fourier acquisition single-shot turbo spin-echo and diffusion-weighted imaging. The rest of the evaluation was normal.Conclusions: In cases with a persistent, parenchymal echogenic lesion without clastic or structural changes, DVA should be considered. Demonstration of a collecting vein draining the lesion and normal brain anatomy on MRI confirm the diagnosis. [ABSTRACT FROM AUTHOR]

Published
2018
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16. Callosal injuries in cytomegalovirus fetopathy: a neurosonographic study.

Author

Krajden Haratz K, Malinger G, Miremberg H, Hartoov J, Wolman I, Jaffa A, Busilov M, and Birnbaum R

Abstract

Introduction - This study aimed to describe the rate and pattern of callosal injury in CMV fetopathy. Methods - This retrospective study included fetuses with confirmed CMV-PCR. Dedicated US including neurosonography was performed. Callosal Length below the 5th centile or morphological abnormalities were considered abnormal. Any additional abnormal findings were reported. Results - Seventy-two patients were included. In 76% infection occurred in the 1stT or periconceptional. In 34.7% a callosal anomaly was observed and it was never isolated. CNS abnormalities included: periventricular hyperechogenicity (PVHE) 55.5%, calcifications 52%, ventriculomegaly 33%, periventricular pseudocysts 31.4%, occipital cysts 22.2%, echogenic precaudate germinal matrix 30.5%, LSV 26.4%, sulcation abnormalities 22.2%, cerebellar findings 18% and HC below -2SD 18%. The most common association with CC insult was PVHE (56%) and calcifications (52%). Conclusion - Although not referred to as a classic brain structure affected by CMV infection, the CC was injured in one-third of our patients, including cases of late infection. The mechanism of disease and the prenatal patterns of callosal involvement in these cases appear to be different from the postnatal patterns and are not reversible. The presence of a callosal injury would imply a worse prognosis and a significant increment in the risk of neurodevelopmental impairment., (The Author(s). Published by S. Karger AG, Basel.)

Published
2024
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17. Brain Metabolite Differences in Fetuses With Cytomegalovirus Infection: A Magnetic Resonance Spectroscopy Study.

Author

Sadan OR, Avisdris N, Rabinowich A, Link-Sourani D, Krajden Haratz K, Garel C, Hiersch L, Ben Sira L, and Ben Bashat D

Abstract

Background: Cytomegalovirus (CMV) is the most common intrauterine infection and may be associated with unfavorable outcomes. While some CMV-infected fetuses may show gross or subtle brain abnormalities on MRI, their clinical significance may be unclear. Conversely, normal development cannot be guaranteed in CMV-infected fetuses with normal MRI., Purpose: To assess brain metabolite differences in CMV-infected fetuses using magnetic resonance spectroscopy (MRS)., Study Type: Retrospective., Subjects: Out of a cohort of 149 cases, 44 with maternal CMV infection, amniocentesis results, and good-quality MRS were included. CMV-infected fetuses with positive polymerase chain reaction (PCR) (N = 35) were divided based on MRI results as follows: typical brain abnormalities (gross findings, N = 8), exclusive white matter hyperintense signal (WMHS) on T 2 -weighted images (subtle findings, N = 7), and normal MRI (N = 20). Uninfected fetuses (negative PCR) with normal MRI were included as controls (N = 9)., Field Strength: 3 T, T 2 -weighted half Fourier single-shot turbo spin-echo (HASTE), T 2 -weighted true fast imaging with steady-state free precession (TrueFISP), T 1 - and T 2 *-weighted fast low angle shot (FLASH), and 1 H-MRS single-voxel point resolved spectroscopy (PRESS) sequences., Assessment: MRI findings were assessed by three radiologists, and metabolic ratios within the basal ganglia were calculated using LCModel., Statistical Tests: Analysis of covariance test with Bonferroni correction for multiple comparisons was used to compare metabolic ratios between groups while accounting for gestational age. A P-value <0.05 was deemed significant., Results: MRS was successfully acquired in 63% of fetuses. Substantial agreement was observed between radiologists (Fleiss' kappa [k] = 0.8). Infected fetuses with gross MRI findings exhibited significantly reduced tNAA/tCr ratios (0.64 ± 0.08) compared with infected fetuses with subtle MRI findings (0.85 ± 0.19), infected fetuses with normal MRI (0.8 ± 0.14) and controls (0.81 ± 0.15). No other significant differences were detected (P ≥ 0.261)., Conclusion: Reduced tNAA/tCr within the apparently normal brain tissue was detected in CMV-infected fetuses with gross brain abnormalities, suggesting extensive brain damage. In CMV-infected fetuses with isolated WMHS, no damage was detected by MRS., Level of Evidence: 3 TECHNICAL EFFICACY: Stage 3., (© 2024 The Author(s). Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Published
2024
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18. Unique Imaging Features Enabling the Prenatal Diagnosis of Developmental Venous Anomalies: A Persistent Echogenic Brain Lesion Drained by a Collecting Vein in Contrast with Normal Brain Parenchyma on MRI.

Author

Krajden Haratz K, Peled A, Weizman B, Gindes L, Tamarkin M, Lev D, Kidron D, Ben-Sira L, Malinger G, Lerman-Sagie T, and Leibovitz Z

Subjects
Abortion, Induced, Adult, Age Factors, Autopsy, Central Nervous System Vascular Malformations pathology, Cerebral Veins abnormalities, Cerebral Veins pathology, Child Development, Female, Gestational Age, Humans, Infant, Predictive Value of Tests, Pregnancy, Prognosis, Reproducibility of Results, Central Nervous System Vascular Malformations diagnostic imaging, Cerebral Veins diagnostic imaging, Magnetic Resonance Imaging, Parenchymal Tissue diagnostic imaging, Ultrasonography, Doppler, Transcranial, Ultrasonography, Prenatal methods
Abstract

Objective: To describe the prenatal imaging features enabling diagnosis of developmental venous anomalies (DVA)., Methods: Four fetuses with unexplained persistent echogenic parenchymal brain lesions were studied. The evaluation included dedicated neurosonography, fetal MRI, serology for intrauterine infection, screening for coagulation abnormalities, and chromosomal microarray. Postnatal neurodevelopmental follow-up or autopsy results were assessed., Results: DVA presented as very slowly growing echogenic brain lesions without cystic components, calcifications, or structural changes on otherwise normal neurosonographic scans performed at 2- to 3-week intervals. A specific Doppler feature was a collecting vein draining the echogenic parenchyma. Fetal brain MRI depicted normal anatomy on half-Fourier acquisition single-shot turbo spin-echo and diffusion-weighted imaging. The rest of the evaluation was normal., Conclusions: In cases with a persistent, parenchymal echogenic lesion without clastic or structural changes, DVA should be considered. Demonstration of a collecting vein draining the lesion and normal brain anatomy on MRI confirm the diagnosis., (© 2017 S. Karger AG, Basel.)

Published
2018
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