343 results on '"Kozielski, Frank"'
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2. High-confidence placement of low-occupancy fragments into electron density using the anomalous signal of sulfur and halogen atoms
3. Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ
4. Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation
5. New insights into complex formation by SARS-CoV-2 nsp10 and nsp14.
6. Author Response: Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16
7. Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16
8. Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors
9. Oligomeric State of β-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering
10. High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction—A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1
11. New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations
12. Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16.
13. pH-dependent crystal structures of a humanised therapeutic antibody Fab fragment: impact on molecular dynamics simulations and comparison to solution structures
14. Supporting Video 04 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes
15. Supporting Video 11 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes
16. Supplementary Table 1 and Supplementary Figures 1-3 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes
17. Suporting Video Legends from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes
18. Data from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes
19. Data from Docetaxel-Resistant Prostate Cancer Cells Remain Sensitive to S-Trityl-l-Cysteine–Mediated Eg5 Inhibition
20. Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics
21. Supplementary Data from Docetaxel-Resistant Prostate Cancer Cells Remain Sensitive to S-Trityl-l-Cysteine–Mediated Eg5 Inhibition
22. Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16
23. Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
24. Author response: Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
25. Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening
26. Cytomotive actins and tubulins share a polymerisation switch mechanism conferring robust dynamics
27. STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity
28. “Snapshots” of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5
29. Doing the methylene shuffle – Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine
30. Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives
31. The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer
32. Revealing druggable cryptic pockets in the Nsp-1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
33. Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode
34. The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition
35. Motor-Dependent Microtubule Disassembly Driven by Tubulin Tyrosination
36. Elucidating the functionality of kinesins: An overview of small molecule inhibitors
37. Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl- l-cysteine in tumor derived cell lines
38. Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
39. Crystallographic fragment screen against SARS-CoV-2 nsp10
40. Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain
41. Structural Variations in Protein Superfamilies: Actin and Tubulin
42. Structure of Human Eg5 in Complex with a New Monastrol-based Inhibitor Bound in the R Configuration
43. Modified Peptide Inhibitors of the Keap1–Nrf2 Protein–Protein Interaction Incorporating Unnatural Amino Acids
44. New chemical tools for investigating human mitotic kinesin Eg5
45. The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins
46. Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5
47. Interaction of the mitotic inhibitor monastrol with human kinesin Eg5
48. S-Trityl-L-cysteine Is a Reversible, Tight Binding Inhibitor of the Human Kinesin Eg5 That Specifically Blocks Mitotic Progression
49. Molecular Dissection of the Inhibitor Binding Pocket of Mitotic Kinesin Eg5 Reveals Mutants that Confer Resistance to Antimitotic Agents
50. Structural links to kinesin directionality and movement
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