The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins

Authors :: Brier, Sebastien
Carletti, Eugenie
DeBonis, Salvatore
Hewat, Elisabeth
Lemaire, David
Kozielski, Frank
Source :: Biochemistry. Dec 26, 2006, Vol. 45 Issue 51, p15644, 10 p.
Publication Year :: 2006
Abstract: The adociasulfate-2 (AS-2) binding regions of two human kinesins, centromere-associated protein E (CENP-E), a member of the kinesin-7 family, the Eg5, a member of the kinesin-5 family and the microtubules (MT)-binding region are investigated. The results have shown that AS-2 is a MT-competitive inhibitor of the human CENP-E motor domain.

Subjects :: Protein binding -- Research
Kinesin -- Chemical properties
Kinesin -- Research
Centromeres -- Structure
Centromeres -- Research
Biological sciences
Chemistry

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