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Objective: The aim: Analysis of electrocardiographic parameters in newborns from mothers with metabolic syndrome., Patients and Methods: Materials and methods: We conducted a prospective cohort trial of 125 newborns, which included the study of their anthropometric, clinical and laboratory indicators and, in particular, ECG parameters. The main group consisted of 40 children, born from mothers with diagnosed metabolic syndrome, the comparison group included 2 subgroups: 28 term newborn and 57 preterm, from mothers without metabolic syndrome., Results: Results: In newborns from mothers with metabolic syndrome on a fragmentary ECG we revealed abnormal depolarization, manifested by changes in the ventricular complex -QRS expansion (p<0.001), impaired conduction (p = 0.004), changes of T wave (p<0.001) and prolonged QT interval (p<0.001). There are such risk factors for QT prolongation in neonates: disease cardiovascular system and disorders of lipid metabolism in mother, asphyxia at birth and electrolyte disorders (hypernatremia OR 0.97), weight too high to gestational age at birth in newborn (OR 2.97), increased blood pressure in the neonatal period (OR 1.07), artificial feeding (OR 3.01)., Conclusion: Conclusions: Metabolic syndrome in women during pregnancy has a pronounced effect on the cardiovascular system of the newborn. The detected signs of cardiac dysfunction on the ECG can serve as early integrated indicators of metabolic syndrome and cardiovascular disease in children.

Objective: Introduction: Severe intraventricular hemorrhages (IVH) in preterm infants are one of the major public health problems, as they can cause neurological and cognitive impairment, as well as lethal outcomes. The aim: To prevent the development of IVH in preterm infants by developing an algorithm for identification of high risk infants and a bundle for the prediction and prevention of this pathology., Patients and Methods: Materials and methods: A multicenter study (2013-2016) was conducted, which included 117 premature babies who were on treatment in 4 medical institutions in the Poltava region (Ukraine). The group of children with severe IVH included 76 children (weight 1037.8 ± 43.7 g, gestational age (GA) 27.1 ± 0.27 weeks; girls 36/47, 37 %), with IVH III-IV st. by Papile L.A. The comparison group consisted of 41 children (weight 1758 ± 59.8, GA 32.1 ± 0.30 weeks, girls 15/38, 46 %) without IVH. The effectiveness of a bundle for the prediction and prevention severe IVH was studied in the Poltava Regional Perinatal Center (high level, 2000 births per year) during 2014 - 2017., Results: Results: The significant risk factors due to multiple regression logistic analysis are: gestational age (OR =0.28, р=0.000), anhydrous period less than 24 hours (OR =83,29; р=0.020), infusion of 0.9% sodium chloride solution during primary resuscitation (OR =16.73; р=0.042), episodes of arterial hypertension (OR =32.3; р=0.026), the number of leukocytes is ≥15x109/l at birth (OR=17.6; р=0.028). After the implementation of the Bundle, which included: an interdisciplinary check-list (between the obstetrician and the neonatologist), the algorithm for identifying children with high risk of IVH, a check-list for monitoring of the state of the child immediately after birth and an interprofessional check-list (between the doctor and the nurse), the IVH incidence decreased from 18.9 % to 11.4 %, p = 0.038, and the disability from 9.6 % to 2.4 %, p = 0.046., Conclusion: Conclusions: The Bundle is an effective tool for preventing of severe IVH in preterm infants.

Objective: Introduction: At present, the world faces an extremely heterogeneous situation in providing population with access to intensive care. In healthcare systems of different countries, there are significant differences in the number of available ICU beds per 10 thousand population. Even in the united Europe, the indicator is extremely variable and ranges from 0.42 ICU beds per 10.000 population in Portugal to 2.92 ICU beds per 10.000 population in Germany (a difference of almost 7 times), amounting to an average of 1.15 ICU beds per 10 thousand population The aim: To identify major trends in the number of ICU beds, the number of ICU patients and the rates of ICU mortality in Ukraine over the period of time from 2007 to 2015 based on the analysis of available data on the national intensive care service., Patients and Methods: Materials and methods: The data from the 2007 nationwide audit of the domestic intensive care service and the summarized 2015 annual reports from the regional intensive care services, encompassing all the healthcare facilities that provide intensive care to population (819 hospitals in total) and represent 22 out of 26 administrative territories (regions) of the country, have been used to carry out comparative, 2015 vs. 2007, analysis and establish major trends in the indicators of interest., Results: Results: The negligible increase in the number of ICU beds on referential territories in absolute (from 4.765 to 5.049) and relative (from 1.4 to 1.5 per 10 thousand population) figures have been found within the period of time from 2007 to 2015. In contrast, more prominent increase in the number of ICU patients (from 385.068 to 462.395 in absolute figures and from 111.6 to 138.2 per 10 thousand population) and in ICU mortality rates (from 8.4% to 8.7%) have been established. The average Ukrainian figure of the number of ICU beds per 10 thousand population for the year 2015 (1.5) seems to be roughly comparable with the corresponding European one for the year 2012 (1.15)., Conclusion: Conclusions: The inclining trends in the number of ICU patients and ICU mortality rates, against the background of negligible growth in the bed capacity of the national intensive care service, indicate the need in the increase in the number of ICU beds in Ukraine.