33 results on '"Kotake, Yatsugu"'
Search Results
2. Marked regression of liver metastasis by combined therapy of ultrasound-mediated NFkB-decoy transfer and transportal injection of paclitaxel, in mouse
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Azuma, Haruhito, Tomita, Naruya, Sakamoto, Takeshi, Kiyama, Satoshi, Inamoto, Teruo, Takahara, Kiyoshi, Kotake, Yatsugu, Segawa, Naoki, Morishita, Ryuichi, Takahara, Shiro, Hayasaki, Hana, Otsuki, Yoshinori, Horie, Shigeo, Tanigawa, Nobuhiko, and Katsuoka, Yoji
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- 2008
- Full Text
- View/download PDF
3. Metastases to the penis from carcinoma of the prostate
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KOTAKE, YATSUGU, GOHJI, KAZUO, SUZUKI, TOSHIAKI, WATSUJI, TOSHIKAZU, KUSAKA, MAMORU, TAKAHARA, KENN, UBAI, TAKANOBU, NOUMI, HAYAHITO, INAMOTO, TERUO, SHIBAHARA, NOBUHISA, UEDA, HARUHIKO, and KATSUOKA, YOJI
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- 2001
4. 陰嚢平滑筋肉腫の1例
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Edagawa, Yu, Inamoto, Teruo, Takahara, Kiyoshi, Uehara, Hirofumi, Kotake, Yatsugu, Nomi, Hayato, Ubai, Takanobu, Mizutani, Yoichi, Tsuji, Motomu, and Azuma, Haruhito
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Leiomyosarcoma ,endocrine system ,endocrine system diseases ,urogenital system ,Scrotum ,494.9 ,urologic and male genital diseases - Abstract
A 31-year-old man visited another hospital with a chief complaint of a solid mass in the left scrotum. The diagnosis was a skin cancer of the scrotum, and he was referred to our hospital. We performed surgical resection of the mass, left testis, and bilateral superfical inguinal nodes. Histopathological findings revealed leiomyosarcoma of the scrotum. He is free of disease at 16 months after the operation.
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- 2012
5. Substrate recognition mechanism of the peptidase domain of the quorum-sensing-signal-producing ABC transporter ComA from Streptococcus
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Kotake, Yatsugu, Ishii, Seiji, Yano, Takato, Katsuoka, Yoji, and Hayashi, Hideyuki
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Enzyme binding -- Research ,Proteases -- Chemical properties ,Streptococcus -- Physiological aspects ,Biological sciences ,Chemistry - Abstract
The peptidase domains (PEPs) of the ComAs from six species of Streptococcus and ComCs from four species are expressed, purified and characterized in order to examine the mechanism of the substrate recognition of PEP. Together with the double glycine motif, these structural features of ComC have described the strict substrate specificity of the PEP.
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- 2008
6. Port-site metastasis after retroperitoneoscopy-assisted nephroureterectomy and cystectomy for bladder cancer invading the ureter: a case report
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Segawa, Naoki, Azuma, Haruhito, Takahara, Kiyoshi, Hamada, Syuji, Kotake, Yatsugu, Tsuji, Motomu, and Katsuoka, Yoji
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Port-site metastasis ,Retroperitoneoscopy ,Urothelial carcinoma ,494.9 - Abstract
73歳, 男。肉眼的血尿が出現し, 膀胱鏡検査にて膀胱内左側壁から左尿管口付近にかけて径4cm大の乳頭状広基性腫瘍を認め, 尿細胞診はUrothelial carcinoma(UC), class Vであった。MRI検査では膀胱後壁正中から左側壁に広範に腫瘍が存在し, 筋層断裂と周囲脂肪織への浸潤が疑われた。骨シンチにて第11胸椎に転移巣を認めた。TURBTで腫瘍を切除し, UC, G2>G3で筋層浸潤を認め, T3bN0M1と診断した。CDDP, ADR, MTX, VBLによるM-VAC化学療法を施行し, 骨シンチにて転移巣の消失を認めた。その後のCTで左水腎症, 膀胱腫瘍の増大, 尿管進展により左下部尿管の壁肥厚を認めた。後腹膜鏡補助下左腎尿管全摘術および膀胱全摘除術, 右腎管皮膚瘻造設術を行った。術後約4ヵ月, 左股関節部に疼痛を自覚し, 左腰背部の第2ポート部に一致して径6×4cmの腫瘤を認めた。また, 左大腰筋腹側に42mm大の腫瘍性病変と左恥骨に骨外浸潤する腫瘍を認めた。生検より尿路上皮癌転移巣と判明し, ポート部再発を含む多発性転移と診断した。放射線照射で疼痛は緩和し歩行可能となった。2ヵ月現状維持のまま経過観察中である。, We report a case of port-site metastasis of bladder cancer after left retroperitoneoscopy-assisted nephroureterectomy and cystectomy. The patient was a 73-year-old man with a chief complaint of gross hematuria. The diagnosis was invasive bladder cancer with bone metastasis. He received two courses of chemotherapy (methotrexate, vinblastine, adriamycin, cisplatin), and this resulted in resolution of the bone metastases. Two months later, abdominal and pelvic computed tomography showed a bladder tumor invading the left lower ureter with hydronephrosis. Left retroperitoneoscopy-assisted nephroureterectomy and cystectomy were performed. The patient was unable to undergo systemic chemotherapy because of renal dysfunction. Four months later, a lateral abdominal wall tumor was found at a port-site, and needle biopsy confirmed this to be metastatic urothelial carcinoma. Clinicians need to be aware of port-site metastasis, particularly in patients with UC, and take steps to prevent it during laparoscopic procedures.
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- 2008
7. Renal cell carcinoma with asynchronous contralateral adrenal metastasis and liver cirrhosis (four years after surgery): a case report
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Segawa, Naoki, Azuma, Haruhito, Takahara, Kiyoshi, Hamada, Syuji, Kotake, Yatsugu, Tsuji, Motomu, and Katsuoka, Yoji
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Adrenalectomy ,494.9 ,Renal cell carcinoma ,Adrenal metastasis - Abstract
52歳男。4年前に肝硬変(ウイルス性C型肝炎)と腎機能障害の経過観察中のCT, MRI検査で左腎上極に径4cm大腫瘤を指摘された。脾機能亢進症状で血小板減少を認めたため部分的脾動脈塞栓術(PSE)施行後5週目に経腰的左腎摘出術を施行し左副腎は温存した。腫瘍部は5×5×4cm大で病理所見ではrenal cell carcinoma, granular cell carcinoma, G2pT1b, StageIであった。2~3ヵ月毎の経過観察で再発・転移兆候は認めなかったが, 手術後約3年半のMRIで右副腎に径2.5cm大の腫瘤を認め増大傾向にあるため精査加療目的入院となった。T1WIで中間信号, T2WIでやや高信号域, CTより右副腎は2.5×3cm 大に腫大し, 副腎皮質シンチで両副腎に取り込みを認め, 6ヵ月後に後腹膜鏡下右副腎摘除術を施行した。腫瘍は4×4.5×2cm大の割面は黄褐色でRCC clear cellの転移病巣で, 病理所見よりrenal cell carcinomaと判明した。術後9日目に退院し, 免疫療法は施行せず, 術後7ヵ月現在再発・転移の兆候は認めていない。, We report a case of adrenal metastasis from renal cell carcinoma. A 52-year-old man was referred to our hospital for a left renal mass. A computed tomography revealed a left renal tumor. Liver cirrhosis and splenomegaly were observed. Blood tests revealed pancytopenia; platelet count was 2.5 x 10(4)/mm3. The patient was treated by partial splenic embolization (PSE) in an attempt to ensure a safe nephrectomy. After the embolization, his platelet count increased to 6.1 x 10(4)/mm3, and left nephrectomy was performed successfully. Histopathological finding was renal cell carcinoma (RCC). We concluded that PSE before surgery was useful for the patients with thrombocytopenia due to hypersplenism. Four years after surgery, computed tomography revealed the presence of a mass on the right adrenal gland. He was suspected of having a non-functioning adrenal tumor. Metastasis of the RCC was suspected and right adrenalectomy was performed by a laparoscopic procedure. Histologically, the mass was identified as a RCC metastasis. It is clinically rare for an RCC metastasis to the contralateral adrenal gland to occur.
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- 2007
8. Bladder cancer with skin metastasis: a case report
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Segawa, Naoki, Kotake, Yatsugu, Hamada, Shuji, Takahara, Kiyoshi, Azuma, Haruhito, Katsuoka, Yoji, and Tsuji, Motomu
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Bladder cancer ,494.9 ,Skin metastasis - Abstract
68歳男。無症候性肉眼的血尿が出現し膀胱癌と診断され、以後13年間に再発・転移を繰り返し、経尿道的切除術、抗癌剤の膀胱腔内注入療法、放射線療法、膀胱全摘除術が行われていた。膀胱全摘から約2年後に前頭部、前胸部、背部、右腋窩、右上唇部に発赤を伴う隆起性病変が出現し、楔状切除を行い、病理組織学的所見より膀胱癌の皮膚転移と診断された。また、呼吸器内科での気管支鏡検査で左上葉気管支入口部に転移巣を認めた。胸部X-Pでは左無気肺を呈しており、造影CTでは右肺上葉に結節陰影、左肺門部リンパ節腫大を認めた。左肺門部腫瘤に対し放射線照射を行い、左無気肺は改善したが、全身倦怠感が出現し、腹部CTで肝・骨・左副腎・膵に転移巣が判明し、悪液質の進行にて死亡した。, Bladder carcinoma with skin metastasis is extremely rare. We herein report a case of a bladder tumor with skin metastasis. A 68-year-old man was referred to our hospital with macroscopic hematuria. Cystoscopy revealed a trigone papillary tumor. Transurethral resection of bladder tumor (TURBT) was performed and the pathological diagnosis was transitional cell carcinoma (TCC), pT1, G3. Thereafter, he received several courses of TURBT, intravesical chemotherapy (pirarubicin, bacillus Calmette-Guerin and mitomycin C) and intra-arterial chemotherapy because of recurrence. Thirteen years later, he underwent total cystoprostatectomy with neobladder formation. Histological examination revealed muscle-invasive bladder cancer with a staging of T3bNOM0. Two years and three months later, multiple firm nodules with eruptions appeared on the skin in several regions; they were resected and the histological findings revealed TCC. This indicated metastatic spread from the primary bladder TCC. He received only supportive treatment during this period due to renal dysfunction. He died four months after the manifestation of the skin metastasis due to multiple metastases.
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- 2006
9. Nephrocalcinosis due to renal tubular acidosis in two brothers
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Segawa, Naoki, Kiyama, Satoshi, Azuma, Haruhito, Kotake, Yatsugu, Ashida, Akira, Tamai, Hiroshi, and Katsuoka, Yoji
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Nephrocalcinosis ,Renal tubular acidosis ,Nerve deafness ,494.9 - Abstract
症例1(25歳男).左側腹部痛を主訴とした.生後2ヵ月時に腎尿細管性アシドーシス(RTA)と診断され, 3歳時には両側性蝸牛性感音性難聴, 4歳時には腎石灰化症と診断された.これまでクエン酸, カリウム製剤の投薬を受けていたが, たびたび低K血症症状と高CRK血症を来した.検査所見では代謝性アシドーシス, 尿濃縮能低下, 尿酸性化能低下を認め, 遠位尿細管性アシドーシス(dRTA)と診断された.KUBで両側腎に粟粒大・散在性の石灰沈着像を多数認め, 第3腰椎左側に尿管結石像を認めた.dRTAが原因の尿管結石と診断し, 体外衝撃波結石破砕術を施行したところ破砕良好であった.症例2(症例1の長兄, 31歳男).2歳6ヵ月時にdRTAと診断された.感音性難聴, 腎性くる病, 腎石灰化症と診断され, 腎結石として度々自排し, 成分はリン酸Caであった.ビタミン D療法, アルカリ製剤内服治療中である.dRTAの同胞発症例の報告は検索した限り, 本症例が我が国で3例目と稀であるが, これらの合併症を有する兄弟発生例は実際は多く存在していると思われる, A 25-year-old man was admitted to our hospital because of left lumbago. An abdominal X-ray film demonstrated multiple calculi in the medullary positions of both kidneys and an impacted calculus in the left ureter. He was diagnosed with bilateral nephrocalcinosis and nerve deafness due to distal renal tubular acidosis (RTA) in childhood and was treated with alkali agents for several years. Extracorporeal shock wave lithotripsy was performed successfully against the left ureteral calculus. His older brother had also been diagnosed with RTA and nephrocalcinosis at the age of 2 years and 6 months. Nephrocalcinosis due to RTA associated with nerve deafness in brothers is rarely reported.
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- 2006
10. Complete avulsion of ureter caused by abdominal blunt injury : a case report
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Maruyama, Eikun, Azuma, Haruhito, Kiyama, Satoshi, Kotake, Yatsugu, Inamoto, Teruo, Kiura, Hiromasa, Iwamoto, Yusaku, Ueda, Haruhiko, Katsuoka, Yoji, and Hongo, Yoshihiro
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Blunt injury ,494.9 ,Ureteral avulsion - Abstract
21歳女.主訴は腹痛, 肉眼的血尿.自動車の助手席に乗車中, 電柱に衝突してダッシュボードに腹部を強打した.受傷6時間後のCTでは右後腹膜腔に著明な造影剤の漏出が認められた.RPを施行したところ, CT時に静注した造影剤の抽出は認めたものの, 腎盂尿管移行部で尿管は途絶し, 腎盂は造影されず, 造影剤の大部分は後腹膜腔に漏出した.右上部尿管損傷と診断し, 受傷約15時間後に緊急手術を施行した.右尿管は腎盂尿管移行部で完全に断裂しており, 腎周囲から骨盤腔に至る広範囲の後腹膜腔に尿が貯留していた.断裂した右尿管と右腎盂をAnderson-Hynes法に準じて縫合し, 右腎盂内まで尿管ステントカテーテルを留置した.術後17日目のRPでは吻合部の狭窄や尿溢流は認められず, 尿管ステントを抜去した.また, 術後21日目のDIPでは15分像で軽度の吻合部狭窄を認めるものの, 右腎機能及び右尿管の通過性は良好に保たれていた, A 21-year-old woman who had been injured in a traffic accident appeared with abdominal pain and macroscopic hematuria. Computed tomography (CT) performed 6 hours after the injury showed extravasation of contrast medium in the right retroperitoneal space. Retrograde pyelography (RP) showed the interruption of right ureter at the site of ureteropelvic junction. We performed an abdominal operation 15 hours after the injury under the diagnosis of right ureteral avulsion. We observed a completely separated right ureter at the ureteropelvic junction, and performed an end to end anastomosis. The patient was discharged three weeks after surgery, and has not had any problems for three years.
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- 2004
11. Von Hippel-Lindau disease associated with renal cell carcinoma and bilateral cystadenoma of the epididymis: a case report
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IWAMOTO, Teruo, AZUMA, Haruhito, WATSUJI, Tosikazu, IWAMOTO, Yusaku, SEGAWA, Naoki, SAKAMOTO, Takeshi, KOTAKE, Yatsugu, GOHJI, Kazuo, UEDA, Haruhiko, and KATSUOKA, Yoji
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Cystoadenoma of the epididymis ,Mutation of the VHL gene ,von Hippel-Lindau disease ,494.9 ,Renal cell carcinoma - Abstract
症例は26歳男で, 7年前にvon Hippel-Lindau(VHL)病に合併した骨髄・小脳血管芽腫及び側頭骨乳頭腫に対して摘出術を受け, 以後外来通院していたが, 両側陰嚢内の無痛性腫瘤を触知した.超音波で両側精巣上体に内部不均一な多房性腫瘤を認めると共に, 膵頭部及び両腎に数個の嚢胞を, 右腎外側に径3cmの内部均一な充実性腫瘍を認めた.MRIでは右腎腫瘍はT1強調像でlow, T2強調像でhigh intensityを呈し, 造影効果は認めなかった.摘出術において, 右腎腫瘍は右腎中央に存在し, 2.5×2.5×2cm, 割面黄色で, 白色の線維性被膜でよく被包されていた.両側精巣上体頭部腫瘍は, 右1×3×1cm, 左1×2×1cmで, 腺構造が密に存在し, ところどころで内腔に向かって核異型のない上皮の乳頭状増殖を認めた.またVHL遺伝子の検査を行ったところ, exon 2 351にGからAへの点突然変異を認めた.術後経過は良好で再発はない, We present a case report of von Hippel-Lindau disease associated with renal cell carcinoma and bilateral cystadenoma of the epididymis. A 26-year-old man appeared with painless tumors of the bilateral scrotal contents. Ultrasonography and other radiographic examinations including computed tomographic scan and dripinfusion pyelography showed multiocular tumors in the bilateral epididymis and a right renal tumor 3 cm in diameter. The tumors of the bilateral epididymis were surgically resected and of the right renal tumor enucleated. Histopathological examination revealed cystadenoma of the epididymis and renal cell carcinoma (clear cell carcinoma, G1, pT1a). He has not received adjuvant therapy, and is doing well with no evidence of metastatic disease 2 years after surgery.
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- 2001
12. A case of an infertile man with nonobstructive azoospermia after radical orchiectomy for testicular cancer
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Fujisue, Yutaka, primary, Kono, Junko, additional, Kotake, Yatsugu, additional, Masuda, Hiroshi, additional, Yamashita, Yoshiki, additional, Miyazaki, Kazunori, additional, and Azuma, Haruhito, additional
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- 2015
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13. Ureteral tumor occurring from remaining stump: a case report
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Segawa, Naoki, Kotake, Yatsugu, Noumi, Hayahito, Uchimoto, Shinya, Azuma, Haruhito, Katsuoka, Yoji, and Tsuji, Motomu
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Transitional cell carcinoma ,Ureteral stump ,494.9 ,Ureteral tumor - Abstract
79歳男.無症候性肉眼的血尿を主訴とした.既往には, 27歳時に左腎結核による左腎摘除術があった.尿細胞診は陰性であったが, 膀胱鏡検査で左尿管口存在部に径2~3cmの非乳頭状有茎性腫瘍を認めた.経尿道的膀胱腫瘍切除術を行った.腫瘍は左尿管口より突出し, 移行上皮癌(G1≫G2, pTa)であった.術後の造影CT, MRI検査で左総腸骨動脈交差部以下の遺残尿管内に造影される腫瘍陰影を認めた.全身検索では明らかな転移巣は認められず, 残存尿管摘出術, 及び膀胱部分切除術を行った.切除尿管は18cm長で, 内腔には, 尿管口断端より上方5cmにわたり乳頭状広基性腫瘍がみられた.urothelial carcinoma(G2>G3, pT2, pNx, pMx, pR0, pL0, pV0)であった.術後補助療法を行わなかったが経過は順調で, 術後2ヵ月を経て, 明らかな再発, 転移の徴候はない, Primary tumor originated from ureteral stump following nephrectomy for benign disease is extremely rare. A 79-year-old male was referred to our department for asymptomatic macroscopic hematuria. He had undergone left simple nephrectomy for renal tuberculosis 52 years ago. Cystoscopic examination revealed a ureteral tumor on the residual ureteral orifice. Under the diagnosis of left ureteral stump tumor, which was subsequently enhanced on computer tomographic scan and magnetic resonance imaging, he received partial cystectomy and excision of the left ureteral stump. The histological examination revealed grade 2 to 3 urothelial carcinoma with muscle invasion (pT2). He received no adjuvant chemotherapy. He is now alive and free from recurrence 2 months post-operatively. This is the 21st case reported in the Japanese literature.
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- 2006
14. A great option for elderly patients with locally invasive bladder cancer, BOAI-CDDP-radiation (OMC regimen)
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AZUMA, HARUHITO, primary, INAMOTO, TERUO, additional, TAKAHARA, KIYOSHI, additional, NOMI, HAYAHITO, additional, HIRANO, HAJIME, additional, UEHARA, HIROSHI, additional, KOMURA, KAZUMASA, additional, MINAMI, KOICHIRO, additional, KOUNO, JUNKO, additional, KOTAKE, YATSUGU, additional, ABE, HIROKAZU, additional, TAKAGI, SHIZUKO, additional, IBUKI, NAOKAZU, additional, YAMAMOTO, KAZUHIRO, additional, NARUMI, YOSHIHUMI, additional, and KIYAMA, SATOSHI, additional
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- 2013
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15. Effect of a novel bladder preservation therapy, BOAI-CDDP-radiation (OMC-regimen)
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AZUMA, HARUHITO, primary, INAMOTO, TERUO, additional, TAKAHARA, KIYOSHI, additional, NOMI, HAYAHITO, additional, UEHARA, HIROSHI, additional, KOMURA, KAZUMASA, additional, MINAMI, KOICHIRO, additional, KOUNO, JUNKO, additional, KOTAKE, YATSUGU, additional, ABE, HIROKAZU, additional, TAKAGI, SHIZUKO, additional, YAMAMOTO, KAZUHIRO, additional, NARUMI, YOSHIHUMI, additional, and KIYAMA, SATOSHI, additional
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- 2013
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16. Total Cystectomy Versus Bladder Preservation Therapy for Locally Invasive Bladder Cancer
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Azuma, Haruhito, primary, Yamamoto, Kazuhiro, additional, Inamoto, Teruo, additional, Ibuki, Naokazu, additional, Kotake, Yatsugu, additional, Sakamoto, Takeshi, additional, Kiyama, Satoshi, additional, Ubai, Takanobu, additional, Takahara, Kiyoshi, additional, Segawa, Naoki, additional, Narumi, Yoshihumi, additional, and Katsuoka, Yoji, additional
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- 2009
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17. Anticancer Effect of Combination Therapy of VP16 and Fosfesterol in Hormone-Refractory Prostate Cancer
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Azuma, Haruhito, primary, Sakamoto, Takeshi, additional, Kiyama, Satoshi, additional, Ubai, Takanobu, additional, Kotake, Yatsugu, additional, Inamoto, Teruo, additional, Takahara, Kiyoshi, additional, Nishimura, Yasuichiro, additional, Segawa, Naoki, additional, and Katsuoka, Yoji, additional
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- 2008
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18. Effect of Combined Therapy Using Balloon-Occluded Arterial Infusion of Cisplatin and Hemodialysis With Concurrent Radiation for Locally Invasive Bladder Cancer
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Azuma, Haruhito, primary, Kotake, Yatsugu, additional, Yamamoto, Kazuhiro, additional, Sakamoto, Takeshi, additional, Kiyama, Satoshi, additional, Ubai, Takanobu, additional, Inamoto, Teruo, additional, Takahara, Kiyoshi, additional, Matsuki, Mitsuru, additional, Segawa, Naoki, additional, Shibahara, Nobuhisa, additional, and Katsuoka, Yoji, additional
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- 2008
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19. Substrate Recognition Mechanism of the Peptidase Domain of the Quorum-Sensing-Signal−Producing ABC Transporter ComA from Streptococcus
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Kotake, Yatsugu, primary, Ishii, Seiji, additional, Yano, Takato, additional, Katsuoka, Yoji, additional, and Hayashi, Hideyuki, additional
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- 2008
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20. 313: Specific Antibody to cell Surface Antigen of Renal cell Carcinoma Elicits G1/S Arrest via Upregulation of P27KIP1, Reduction of Cyclin-Dependent Kinase 2, and Dephosphorylated Retinoblastoma Substrate
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Inamoto, Teruo, primary, Azuma, Haruhito, additional, Sakamoto, Takeshi, additional, Kiyama, Satoshi, additional, Kotake, Yatsugu, additional, and Katsuoka, Yoji, additional
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- 2007
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21. Invasive Ability of Human Renal Cell Carcinoma Cell Line Caki-2 Is Accelerated by Gamma-Aminobutyric Acid, via Sustained Activation of ERK1/2 Inducible Matrix Metalloproteinases
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Inamoto, Teruo, primary, Azuma, Haruhito, additional, Sakamoto, Takeshi, additional, Kiyama, Satoshi, additional, Ubai, Takanobu, additional, Kotake, Yatsugu, additional, Watanabe, Masahito, additional, and Katsuoka, Yoji, additional
- Published
- 2007
- Full Text
- View/download PDF
22. Metastases to the penis from carcinoma of the prostate.
- Author
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Gohji, Kazuo, Kotake, Yatsugu, Suzuki, Toshiaki, Watsuji, Toshikazu, Kusaka, Mamoru, Takahara, Kenn, Ubai, Takanobu, Noumi, Hayahito, Inamoto, Teruo, Shibahara, Nobuhisa, Ueda, Haruhiko, and Katsuoka, Yoji
- Subjects
- *
METASTASIS , *PROSTATE cancer , *PENILE cancer - Abstract
Abstract A 58-year-old man presented with dysuria at the Osaka Medical College Hospital in November 1996. Laboratory examination revealed elevated serum prostate-specific antigen (PSA) to > 100 ng/mL. Adenocarcinoma of the prostate with metastasis to the bone was diagnosed after a biopsy of the prostate and bone scintigraphy; hormonal therapy was administered. Although bone metastasis was well controlled and the serum PSA level declined to within normal levels (2.0 ng/mL), several painless nodules were found on the penile glans. Biopsy of the nodules showed that the penile tumor was a metastasis from the prostate cancer. The patient underwent partial penectomy for relief from penile pain. The serum PSA level showed no elevation 3 months after the partial penectomy, suggesting that careful observation of prostate cancer patients is necessary, even when oseous metastasis is well controlled and serum PSA levels are kept within normal ranges by hormonal therapy. The case also indicates that urologists should consider the possibility of metastasis to the penis from prostate cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2001
23. [Leiomyosarcoma of the scrotum].
- Author
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Edagawa Y, Inamoto T, Takahara K, Uehara H, Kotake Y, Nomi H, Ubai T, Mizutani Y, Tsuji M, and Azuma H
- Subjects
- Adult, Genital Neoplasms, Male surgery, Humans, Leiomyosarcoma surgery, Male, Genital Neoplasms, Male pathology, Leiomyosarcoma pathology, Scrotum
- Abstract
A 31-year-old man visited another hospital with a chief complaint of a solid mass in the left scrotum. The diagnosis was a skin cancer of the scrotum, and he was referred to our hospital. We performed surgical resection of the mass, left testis, and bilateral superfical inguinal nodes. Histopathological findings revealed leiomyosarcoma of the scrotum. He is free of disease at 16 months after the operation.
- Published
- 2012
24. Utility of the novel bladder preservation therapy, BOAI-CDDP-radiation (OMC-regimen), for elderly patients with invasive bladder cancer.
- Author
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Azuma H, Inamoto T, Ibuki N, Ubai T, Kotake Y, Takahara K, Kiyama S, Nomi H, Uehara H, Komura K, Yamamoto K, Narumi Y, and Katsuoka Y
- Subjects
- Aged, Aged, 80 and over, Catheterization methods, Cisplatin administration & dosage, Combined Modality Therapy, Cystectomy, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Disease-Free Survival, Female, Humans, Infusions, Intra-Arterial, Male, Neoplasm Staging, Risk Factors, Survival Analysis, Treatment Outcome, Urinary Bladder Neoplasms pathology, Gemcitabine, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Urinary Bladder Neoplasms therapy
- Abstract
In this study, we investigated the novel bladder preservation therapy, the balloon-occluded arterial infusion (BOAI) of cisplatin/gemcitabine, concomitantly with hemodialysis, along with concurrent irradiation [the 'Osaka Medical College (OMC)-regimen'] in patients >70 years of age with muscle-invasive bladder cancer. Eighty-three such patients were assigned to receive either the OMC-regimen (n=56) or cystectomy (n=27). The OMC-regimen patients who failed to achieve complete response (CR) underwent cystectomy, or secondary BOAI with gemcitabine (1600 mg). The OMC-regimen, which delivers an extremely high concentration of anti-cancer agent to the tumor site without systemic adverse effects, yielded CR in >90% (39/43) of patients with locally invasive tumors [70% (39/56) of all patients including those with T4 and N+ disease]. None of the CR patients showed recurrence after a mean follow-up of 162 (range, 35-683) weeks, and 2 patients died of unrelated causes. The 5- and 12-year overall survival rates were 92.7 and 69.5% (vs. 59.6 and 20.9% for cystectomy; P<0.0092), respectively, although the median age in the OMC-regimen group was significantly greater than that in the cystectomy group (median, 77; range, 70-98; vs. 74; 70-79; p<0.0001). No patients suffered grade III or more severe toxicities. The oldest patient, aged 98 years, successfully completed this therapy. The OMC-regimen is a useful bladder preservation strategy for elderly patients with locally invasive bladder cancer, not only for those for whom cystectomy has been indicated, but also for patients whose condition is not amenable to curative treatment and for whom palliation would otherwise seem the only option.
- Published
- 2011
25. Novel bladder preservation therapy for locally invasive bladder cancer: combined therapy using balloon-occluded arterial infusion of anticancer agent and hemodialysis with concurrent radiation.
- Author
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Azuma H, Inamoto T, Ibuki N, Ubai T, Kotake Y, Takahara K, Kiyama S, Nomi H, Uehara H, Komura K, Yamamoto K, Narumi Y, and Katsuoka Y
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols adverse effects, Cisplatin administration & dosage, Deoxycytidine administration & dosage, Deoxycytidine analogs & derivatives, Disease-Free Survival, Female, Humans, Infusions, Intra-Arterial, Japan, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Odds Ratio, Proportional Hazards Models, Radiotherapy, Adjuvant, Risk Assessment, Risk Factors, Survival Rate, Time Factors, Treatment Outcome, Urinary Bladder Neoplasms drug therapy, Urinary Bladder Neoplasms mortality, Urinary Bladder Neoplasms pathology, Urinary Bladder Neoplasms radiotherapy, Urinary Bladder Neoplasms surgery, Gemcitabine, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Balloon Occlusion, Cystectomy, Renal Dialysis, Urinary Bladder Neoplasms therapy
- Abstract
We investigated the effect of balloon-occluded arterial infusion (BOAI) of anticancer agent (cisplatin/gemcitabine), used concomitantly with hemodialysis, which delivers an extremely high concentration of anticancer agent to the site of a tumor without systemic adverse effects, along with concurrent radiation (referred to as the OMC-regimen) in patients with advanced bladder cancer. One hundred and ninety-two patients were assigned to receive either the OMC-regimen (n=96) or total cystectomy (n=96). Patients in the OMC-regimen group who failed to achieve CR underwent cystectomy, or secondary BOAI with an increased amount of CDDP or gemcitabine (1600 mg). The OMC-regimen allowed >89% (69/77) of patients with locally invasive tumors to achieve CR [>70% (70/96) of all patients including those with T4 and N(+) disease]. Most (68/69) of the CR patients were still alive with no evidence of recurrence after a mean follow-up of 161 (range 12-805) weeks. The 5- and 15-year overall survival rates were 91.5 and 81.3% (vs. 59.8% and 40.1% for cystectomy, P<0.0001), respectively. No patients suffered Grade III or more severe toxicities. In contrast, at 5 and 15 years after surgery in the total cystectomy group, about 50 and 60% of patients had suffered disease progression or had died, respectively. The OMC-regimen, a new bladder-preservation strategy for patients with locally invasive bladder cancer, can be curative not only in patients for whom cystectomy is indicated, but also in patients whose condition is not amenable to curative treatment and for whom merely palliative therapy would otherwise seem the only option.
- Published
- 2010
- Full Text
- View/download PDF
26. Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse.
- Author
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Azuma H, Tomita N, Sakamoto T, Kiyama S, Inamoto T, Takahara K, Kotake Y, Segawa N, Morishita R, Takahara S, Hayasaki H, Otsuki Y, Horie S, Tanigawa N, and Katsuoka Y
- Subjects
- Animals, Antineoplastic Agents, Phytogenic pharmacology, Apoptosis, Cell Line, Tumor, Chemotherapy, Adjuvant, Colorimetry, Down-Regulation, Flow Cytometry, Gene Expression Regulation, Neoplastic, Humans, Immunoblotting, Injections, Intravenous, Liver Neoplasms diagnostic imaging, Liver Neoplasms drug therapy, Mice, Mice, Inbred BALB C, Mice, Nude, Microscopy, Fluorescence, NF-kappa B metabolism, Oligodeoxyribonucleotides administration & dosage, Oligonucleotide Array Sequence Analysis, Paclitaxel pharmacology, Portal Vein, Random Allocation, Reverse Transcriptase Polymerase Chain Reaction, Ultrasonography, Antineoplastic Agents, Phytogenic administration & dosage, Colonic Neoplasms pathology, Genetic Therapy methods, Liver Neoplasms secondary, Liver Neoplasms therapy, NF-kappa B antagonists & inhibitors, Paclitaxel administration & dosage, Transfection methods, Ultrasonics
- Abstract
Nuclear factor-kappaB (NF kappaB) plays a pivotal role in cancer progression. In this study, we developed a decoy cis-element oligo-deoxyribonucleic acid against NF kappaB-binding site (NF kappaB-decoy), which effectively inhibits NF kappaB activity, and tested the effect of combined therapy comprising local transfection of NF kappaB-decoy into the liver and transportal injection of paclitaxel on cancer growth and metastasis using an orthotopic murine model of colon cancer liver metastasis. For NF kappaB-decoy transfection, we employed a novel approach using ultrasound exposure with an echocardiographic contrast agent, Optison. We examined the influence of NF kappaB-decoy transfer on susceptibility to paclitaxel in cancer cells and the mechanism involved using several in vitro analysis systems. We then studied the in vivo effect of combined NF kappaB-decoy transfer and paclitaxel in preventing cancer progression using a murine model of liver metastasis created by splenic injection of a human colon cancer cell line, HT29. In vitro experiments, including MTT-assay, fluorescence-activated cell sorter and cDNA array analysis, revealed that NF kappaB-decoy transfer significantly increased the susceptibility of cancer cells to paclitaxel, and that decreased expression of anti-apoptotic genes along with increased expression of genes relevant to the apoptosis-promotor may be involved. In vivo experiments showed that local transfection of NF kappaB-decoy into the liver followed by portal injection of paclitaxel effectively induced cancer cell apoptosis in the liver metastasis, and significantly prolonged animal survival compared to controls, without notable side effects. In conclusion, a combination of local NF kappaB-decoy transfer into the liver and transportal injection of paclitaxel may be a safe and effective new therapy for liver metastasis., ((c) 2007 Wiley-Liss, Inc.)
- Published
- 2008
- Full Text
- View/download PDF
27. [Port-site metastasis after retroperitoneoscopy-assisted nephroureterectomy and cystectomy for bladder cancer invading the ureter: a case report].
- Author
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Segawa N, Azuma H, Takahara K, Hamada S, Kotake Y, Tsuji M, and Katsuokai Y
- Subjects
- Aged, Carcinoma pathology, Humans, Male, Ureteral Neoplasms pathology, Urinary Bladder Neoplasms pathology, Urothelium, Abdominal Neoplasms secondary, Carcinoma surgery, Cystectomy, Endoscopy adverse effects, Neoplasm Invasiveness, Neoplasm Seeding, Nephrectomy, Ureter surgery, Ureteral Neoplasms surgery, Urinary Bladder Neoplasms surgery
- Abstract
We report a case of port-site metastasis of bladder cancer after left retroperitoneoscopy-assisted nephroureterectomy and cystectomy. The patient was a 73-year-old man with a chief complaint of gross hematuria. The diagnosis was invasive bladder cancer with bone metastasis. He received two courses of chemotherapy (methotrexate, vinblastine, adriamycin, cisplatin), and this resulted in resolution of the bone metastases. Two months later, abdominal and pelvic computed tomography showed a bladder tumor invading the left lower ureter with hydronephrosis. Left retroperitoneoscopy-assisted nephroureterectomy and cystectomy were performed. The patient was unable to undergo systemic chemotherapy because of renal dysfunction. Four months later, a lateral abdominal wall tumor was found at a port-site, and needle biopsy confirmed this to be metastatic urothelial carcinoma. Clinicians need to be aware of port-site metastasis, particularly in patients with UC, and take steps to prevent it during laparoscopic procedures.
- Published
- 2008
28. [Renal cell carcinoma with asynchronous contralateral adrenal metastasis and liver cirrhosis (four years after surgery): a case report].
- Author
-
Segawa N, Azuma H, Takahara K, Hamada S, Kotake Y, Tsuji M, and Katsuoka Y
- Subjects
- Adrenalectomy, Carcinoma, Renal Cell diagnostic imaging, Carcinoma, Renal Cell therapy, Humans, Kidney Neoplasms diagnostic imaging, Kidney Neoplasms therapy, Male, Middle Aged, Splenomegaly complications, Tomography, X-Ray Computed, Adrenal Gland Neoplasms secondary, Carcinoma, Renal Cell pathology, Kidney Neoplasms pathology, Liver Cirrhosis complications
- Abstract
We report a case of adrenal metastasis from renal cell carcinoma. A 52-year-old man was referred to our hospital for a left renal mass. A computed tomography revealed a left renal tumor. Liver cirrhosis and splenomegaly were observed. Blood tests revealed pancytopenia; platelet count was 2.5 x 10(4)/mm3. The patient was treated by partial splenic embolization (PSE) in an attempt to ensure a safe nephrectomy. After the embolization, his platelet count increased to 6.1 x 10(4)/mm3, and left nephrectomy was performed successfully. Histopathological finding was renal cell carcinoma (RCC). We concluded that PSE before surgery was useful for the patients with thrombocytopenia due to hypersplenism. Four years after surgery, computed tomography revealed the presence of a mass on the right adrenal gland. He was suspected of having a non-functioning adrenal tumor. Metastasis of the RCC was suspected and right adrenalectomy was performed by a laparoscopic procedure. Histologically, the mass was identified as a RCC metastasis. It is clinically rare for an RCC metastasis to the contralateral adrenal gland to occur.
- Published
- 2007
29. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.
- Author
-
Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, Takahara S, Otsuki Y, and Katsuoka Y
- Subjects
- Animals, Antineoplastic Agents pharmacology, Apoptosis drug effects, Apoptosis physiology, Carcinoma, Renal Cell metabolism, Carcinoma, Renal Cell pathology, Carcinoma, Renal Cell surgery, Caspase 3 metabolism, Caspase 8 metabolism, Cell Growth Processes drug effects, Cell Line, Tumor, Cisplatin pharmacology, Dose-Response Relationship, Drug, Drug Resistance, Neoplasm, Drug Synergism, Extracellular Signal-Regulated MAP Kinases metabolism, Fingolimod Hydrochloride, Humans, Immunosuppressive Agents pharmacology, Immunosuppressive Agents toxicity, Kidney Neoplasms metabolism, Kidney Neoplasms pathology, Kidney Neoplasms surgery, Kidney Tubules cytology, Kidney Tubules drug effects, Male, Mice, Mice, Inbred BALB C, Nephrectomy, Propylene Glycols toxicity, Sphingosine pharmacology, Sphingosine toxicity, Xenograft Model Antitumor Assays, Carcinoma, Renal Cell drug therapy, Kidney Neoplasms drug therapy, Propylene Glycols pharmacology, Proto-Oncogene Proteins c-bcl-2 metabolism, Sphingosine analogs & derivatives, fas Receptor metabolism
- Abstract
Background: A unique immunosuppressant, FTY720, selectively induces apoptosis in activated lymphocytes, but not in other hematopoietic cells. The potential that this unique mechanism could provide anticancer potential by inducing apoptosis in the human renal cancer cell line, ACHN, which is resistant to cisplatin, and its molecular pathway was investigated., Materials and Methods: The difference in drug susceptibility to FTY720 between cancer cells and non-cancer cells was examined by MTT assay and flow cytometry. Apoptosis assay, including TUNEL staining, electron microscopy and DNA electrophoresis, was performed and the molecular pathway of FTY720 was evaluated by real time RT-PCR and Western blot. The in vivo effect of FTY720 was evaluated using a murine zenograft model., Results: The susceptibility to FTY720 was significantly higher in ACHN cancer cells than in normal renal tubular cells (HK-2) at a concentration of less than 30 microM, while the susceptibility to cisplatin was even higher in HK-2 than in ACHN. Cancer cells treated with FTY720 showed findings typical of apoptosis with highly condensed nuclear chromatin and fragmented nuclei. The molecular analysis revealed that FTY720-induced apoptosis was mediated by a Fas-independent, Bcl-associated signal transduction pathway, and that inhibition of extracellular signal-regulated kinase (ERK) activity was involved in its underlying mechanism of action. FTY720 treatment significantly prevented in vivo tumor growth without any severe adverse reactions, while cisplatin treatment did not inhibit tumor growth despite exhibiting severe side-effects., Conclusion: FTY720 may be a promising candidate for a new anticancer therapy of renal cancer.
- Published
- 2007
30. [Bladder cancer with skin metastasis: a case report].
- Author
-
Segawa N, Kotake Y, Hamada S, Takahara K, Azuma H, Katsuoka Y, and Tsuji M
- Subjects
- Administration, Intravesical, Aged, Carcinoma, Transitional Cell drug therapy, Carcinoma, Transitional Cell radiotherapy, Carcinoma, Transitional Cell surgery, Cisplatin administration & dosage, Combined Modality Therapy, Cystectomy, Doxorubicin administration & dosage, Doxorubicin analogs & derivatives, Humans, Infusions, Intra-Arterial, Male, Methotrexate administration & dosage, Mitomycin administration & dosage, Urinary Bladder Neoplasms drug therapy, Urinary Bladder Neoplasms radiotherapy, Urinary Bladder Neoplasms surgery, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Transitional Cell secondary, Skin Neoplasms secondary, Urinary Bladder Neoplasms pathology
- Abstract
Bladder carcinoma with skin metastasis is extremely rare. We herein report a case of a bladder tumor with skin metastasis. A 68-year-old man was referred to our hospital with macroscopic hematuria. Cystoscopy revealed a trigone papillary tumor. Transurethral resection of bladder tumor (TURBT) was performed and the pathological diagnosis was transitional cell carcinoma (TCC), pT1, G3. Thereafter, he received several courses of TURBT, intravesical chemotherapy (pirarubicin, bacillus Calmette-Guerin and mitomycin C) and intra-arterial chemotherapy because of recurrence. Thirteen years later, he underwent total cystoprostatectomy with neobladder formation. Histological examination revealed muscle-invasive bladder cancer with a staging of T3bNOM0. Two years and three months later, multiple firm nodules with eruptions appeared on the skin in several regions; they were resected and the histological findings revealed TCC. This indicated metastatic spread from the primary bladder TCC. He received only supportive treatment during this period due to renal dysfunction. He died four months after the manifestation of the skin metastasis due to multiple metastases.
- Published
- 2006
31. [Ureteral tumor occurring from remaining stump: a case report].
- Author
-
Segawa N, Kotake Y, Noumi H, Uchimoto S, Azuma H, Katsuoka Y, and Tsuji M
- Subjects
- Aged, Carcinoma, Transitional Cell etiology, Carcinoma, Transitional Cell surgery, Cystectomy, Humans, Male, Tuberculosis, Renal surgery, Ureteral Neoplasms etiology, Ureteral Neoplasms surgery, Carcinoma, Transitional Cell diagnosis, Nephrectomy, Postoperative Complications, Ureter pathology, Ureteral Neoplasms diagnosis
- Abstract
Primary tumor originated from ureteral stump following nephrectomy for benign disease is extremely rare. A 79-year-old male was referred to our department for asymptomatic macroscopic hematuria. He had undergone left simple nephrectomy for renal tuberculosis 52 years ago. Cystoscopic examination revealed a ureteral tumor on the residual ureteral orifice. Under the diagnosis of left ureteral stump tumor, which was subsequently enhanced on computer tomographic scan and magnetic resonance imaging, he received partial cystectomy and excision of the left ureteral stump. The histological examination revealed grade 2 to 3 urothelial carcinoma with muscle invasion (pT2). He received no adjuvant chemotherapy. He is now alive and free from recurrence 2 months post-operatively. This is the 21st case reported in the Japanese literature.
- Published
- 2006
32. [Nephrocalcinosis due to renal tubular acidosis in two brothers].
- Author
-
Segawa N, Kiyama S, Azuma H, Kotake Y, Ashida A, Tamai H, and Katsuoka Y
- Subjects
- Adult, Deafness complications, Deafness genetics, Humans, Kidney Calculi therapy, Lithotripsy, Siblings, Ureteral Calculi therapy, Acidosis, Renal Tubular complications, Acidosis, Renal Tubular genetics, Nephrocalcinosis etiology, Nephrocalcinosis genetics
- Abstract
A 25-year-old man was admitted to our hospital because of left lumbago. An abdominal X-ray film demonstrated multiple calculi in the medullary positions of both kidneys and an impacted calculus in the left ureter. He was diagnosed with bilateral nephrocalcinosis and nerve deafness due to distal renal tubular acidosis (RTA) in childhood and was treated with alkali agents for several years. Extracorporeal shock wave lithotripsy was performed successfully against the left ureteral calculus. His older brother had also been diagnosed with RTA and nephrocalcinosis at the age of 2 years and 6 months. Nephrocalcinosis due to RTA associated with nerve deafness in brothers is rarely reported.
- Published
- 2006
33. [Complete avulsion of ureter caused by abdominal blunt injury: a case report].
- Author
-
Maruyama E, Azuma H, Kiyama S, Kotake Y, Inamoto T, Kiura H, Iwamoto Y, Ueda H, Katsuoka Y, and Hongo Y
- Subjects
- Abdominal Injuries diagnostic imaging, Abdominal Injuries surgery, Accidents, Traffic, Adult, Female, Humans, Tomography, X-Ray Computed, Ureter surgery, Wounds, Nonpenetrating diagnostic imaging, Wounds, Nonpenetrating surgery, Abdominal Injuries complications, Ureter injuries, Wounds, Nonpenetrating complications
- Abstract
A 21-year-old woman who had been injured in a traffic accident appeared with abdominal pain and macroscopic hematuria. Computed tomography (CT) performed 6 hours after the injury showed extravasation of contrast medium in the right retroperitoneal space. Retrograde pyelography (RP) showed the interruption of right ureter at the site of ureteropelvic junction. We performed an abdominal operation 15 hours after the injury under the diagnosis of right ureteral avulsion. We observed a completely separated right ureter at the ureteropelvic junction, and performed an end to end anastomosis. The patient was discharged three weeks after surgery, and has not had any problems for three years.
- Published
- 2004
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