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Presents information to sift fact from fancy in the literature dealing with the glands of internal secretion. Description of the position of the glands in the human body; Function of each of these glands to introduce into the blood stream a specific substance which exerts its influence on the body in such a way as to establish an equilibrium and promote health; Details of the history of scientific investigation into the true nature of the activity of glands; Recognition of the thyroid gland as the chief agent in maintaining the equilibrium of the human organism, especially with regard to the delicate balance between the different endocrine organs; Uncertainty of the exact function of the thymus gland; Mention of monkey gland grafts, and the Steinach "operations."

Focuses on an Anti-Alcohol Congress which took place at Copenhagen, Denmark, paid especial attention to an attack upon tobacco. Report that tobacco has been assailed on physical, mental and moral grounds; Comments on the consumption of tobacco; Claims that those engaged in intellectual pursuits or other forms of mental stress are most likely to feel the need of tobacco; Information about Nicotine; Influence of tobacco on heart, mental activity and vascular system; Report that nicotine is the active principle in tobacco; Use of tobacco in the manufacture of the cigarette.

Focuses on some of the facts placed before the public by the American Society for the control of cancer. Increase in the actual number of deaths due to cancer; View cancer as a lawless growth of body cells which destroys life, if allowed to run its course; Formation of malignant tumors due to proliferation of cells; Information on methods for removing cancer easily in its early stages; Discussion on radium or X-ray treatment in curing skin cancers and internal cancers.

In a previous paper1 attention has been directed to the fact that single determinations of gastric acidity by the Rehfuss method are not sufficient on which to base conclusions, because they do not take into account individual variation. Another important question which arises in evaluating results obtained by this method is whether the aliquot fractions aspirated are truly representative of the total gastric contents at the time of withdrawal. Recently, Gorham2 has shown that "the gastric chyme is not, in the majority of instances, a homogeneous mixture after a test meal, and that the acidity of different portions may vary widely." He found on the withdrawal in rapid succession of many samples that there was a marked variation in acidity of these samples in subjects having clinical evidence of gastric disease. Such variations were not so apparent in subjects without clinical evidence of gastric disease, although Wheelon3 has reported some

A recent publication1 dealing with the production of epilepsy in the monkey by the intracortical injection of alumina cream has indicated that certain pertinent information and results are apparently not widely known. The technique for production of experimental epilepsy in the monkey by topical cortical disc application of alumina cream was first described in 1942.2 Thereafter we also reported on the successful use of intracerebral and intracortical injection techniques.* The present communication is intended to present additional data and findings regarding the production of chronic experimental epilepsy in the monkey. METHODS Four preparations of alumina have been employed: a standard laboratory alumina (aluminum oxide) cream made according to Hawk and Bergeim,† using sterile solutions and aseptic technique; a commercial product (aluminum hydroxide, gelatinous A-583, Fisher), autoclaved and emulsified with sterile water by means of a Ten Broeck grinder5; aluminum oxide,‡ autoclaved and emulsified with water to a granular

PREVIOUSLY we1 reported that the experimental production of epilepsy in the monkey was associated with electroencephalographic abnormality. It was noted that in addition to a primary focus in the region of application of the inciting agent, there was evidence of spread of electroencephalographic abnormality to the opposite side of the brain.2 PRESENT INVESTIGATION The present study is concerned with more detailed observations regarding the time relation between electroencephalographic evidence of primary and secondary foci and the onset of convulsive seizures. In addition, the effect of ablation of the "active" focus was investigated. TECHNIC. —In accordance with the method previously described,1a unilateral application of hydrous oxides of aluminum to the motor cortex of 4 monkeys resulted in epileptiform seizures in every instance on physical stimulation. As controls, 3 additional monkeys similarly prepared with noneffective materials at no time manifested convulsive seizures. Electroencephalographic records were taken before operation and

BECAUSE of the dearth of knowledge concerning metabolic changes caused by poliomyelitic infection of the central nervous system, it appeared of interest to study possible electrophysiologic alterations of the brain during the course of the disease. Electroencephalograms were therefore taken of rhesus monkeys and of guinea pigs with experimental infection with simian or murine virus. In addition, 17 persons with postpoliomyelitic paralyses were studied.1Five monkeys were given intracerebral injections of simian virus into the right frontal area: Three received the RMV strain (0.5 cc. of viral cord suspension [1: 10 or 1: 100]); and 2, the Aycock strain (0.5 cc. of a 1:50 suspension). Two additional monkeys served as controls: One was given an intracerebral injection of 0.5 cc. of a 10 per cent Aycock cord suspension inactivated by boiling for twenty minutes, and the other received 0.5 cc. of isotonic solution of sodium chloride. Ten guinea pigs

Bacillus acidophilus has been used successfully in the treatment of constipation and diarrhea.1 However, it would be difficult to state precisely how successful a therapeutic agent it is. Neither of the intestinal conditions dealt with—constipation and diarrhea—permit exact definition; consequently, the interpretation of results must be somewhat arbitrary. For this reason, if no other, it would seem desirable that investigators in this field present their facts as objectively as possible. Obviously, there are many factors which must be considered. The necessity for keeping a careful record of the frequency and character of defecations is well recognized. The dosage of B. acidophilus preparations is always of importance, but unfortunately it is unstandardized and therefore at present has little significance. Thus 10 c.c. of B. acidophilus milk containing 20,000,000 viable organisms per cubic centimeter in the hands of one clinician is unquestionably more desirable than 1,000 c.c. containing 10,000 viable organisms per

Focuses on the prevention of diphtheria. Injection of antitoxin to combat diphtheria; Shortcoming of using antitoxin is that it gives protection for only short periods of time; Determination of whether any individual is susceptible or immune to diphtheria by Schick test; Standardization of outfits for performing Schick test, by the Health Department of New York City; Administration of the horse serum containing antitoxin in the patient with the help of sterilized syringe; Obstacle in the prevention has been great number of healthy individuals who carry diphtheria bacilli in their throats.

Presents several letters to the editor about the articles published in the previous issue of the journal. Comments on the article about the annual convention of the Associated Press written by Oswald Garrison Villard; Appreciation of the journal; Tribute to the judge Joseph Wood Krutch.