Epilepsy in Macaca Mulatta After Cortical or Intracerebral Alumina

A recent publication1 dealing with the production of epilepsy in the monkey by the intracortical injection of alumina cream has indicated that certain pertinent information and results are apparently not widely known. The technique for production of experimental epilepsy in the monkey by topical cortical disc application of alumina cream was first described in 1942.2 Thereafter we also reported on the successful use of intracerebral and intracortical injection techniques.* The present communication is intended to present additional data and findings regarding the production of chronic experimental epilepsy in the monkey. METHODS Four preparations of alumina have been employed: a standard laboratory alumina (aluminum oxide) cream made according to Hawk and Bergeim,† using sterile solutions and aseptic technique; a commercial product (aluminum hydroxide, gelatinous A-583, Fisher), autoclaved and emulsified with sterile water by means of a Ten Broeck grinder5; aluminum oxide,‡ autoclaved and emulsified with water to a granular