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1. Identifying effect modifiers of systemic hydrocortisone treatment initiated 7-14 days after birth in ventilated very preterm infants on long-term outcome: secondary analysis of a randomised controlled trial

Author

Halbmeijer, N.M., Sonnaert, M., Swarte, R.M., Koopman-Esseboom, C., Stuijvenberg, M. van, Mulder-de Tollenaer, S., Tan, R., Mohns, T., Bruneel, E., Steiner, K., Kramer, B.W., Debeer, A., Weissenbruch, M.M. van, Marechal, Y., Blom, H., Plaskie, K., Offringa, M., Merkus, M.P., Onland, W., Leemhuis, A.G., Kaam, A.H. van, Halbmeijer, N.M., Sonnaert, M., Swarte, R.M., Koopman-Esseboom, C., Stuijvenberg, M. van, Mulder-de Tollenaer, S., Tan, R., Mohns, T., Bruneel, E., Steiner, K., Kramer, B.W., Debeer, A., Weissenbruch, M.M. van, Marechal, Y., Blom, H., Plaskie, K., Offringa, M., Merkus, M.P., Onland, W., Leemhuis, A.G., and Kaam, A.H. van

Abstract

Contains fulltext : 305092.pdf (Publisher’s version ) (Closed access), OBJECTIVE: To explore clinical effect modifiers of systemic hydrocortisone in ventilated very preterm infants for survival and neurodevelopmental outcome at 2 years' corrected age (CA). DESIGN: Secondary analysis of a randomised placebo-controlled trial. SETTING: Dutch and Belgian neonatal intensive care units. PATIENTS: Infants born <30 weeks' gestational age (GA), ventilator-dependent in the second week of postnatal life. INTERVENTION: Infants were randomly assigned to systemic hydrocortisone (cumulative dose 72.5 mg/kg; n=182) or placebo (n=190). MAIN OUTCOME MEASURES: The composite of death or neurodevelopmental impairment (NDI) at 2 years' CA and its components. Candidate effect modifiers (GA, small for GA, respiratory index, sex, multiple births, risk of moderate/severe bronchopulmonary dysplasia or death) were analysed using regression models with interaction terms and subpopulation treatment effect pattern plots. RESULTS: The composite outcome was available in 356 (96.0%) of 371 patients (one consent withdrawn). For this outcome, treatment effect heterogeneity was seen across GA subgroups (<27 weeks: hydrocortisone (n=141) vs placebo (n=156), 54.6% vs 66.2%; OR 0.61 (95% CI 0.38 to 0.98); ≥27 weeks: hydrocortisone (n=30) vs placebo (n=31), 66.7% vs 45.2%; OR 2.43 (95% CI 0.86 to 6.85); p=0.02 for interaction). This effect was also found for the component death (<27 weeks: 20.1% vs 32.1%; OR 0.53 (95% CI 0.32 to 0.90); ≥27 weeks: 28.1% vs 16.1%; OR 2.04 (95% CI 0.60 to 6.95); p=0.049 for interaction) but not for the component NDI. No differential treatment effects were observed across other subgroups. CONCLUSION: This secondary analysis suggests that in infants <27 weeks' GA, systemic hydrocortisone may improve the outcome death or NDI, mainly driven by its component death. There was insufficient evidence for other selected candidate effect modifiers.

Published
2024

3. Risk factors for cerebral palsy and movement difficulties in 5-year-old children born extremely preterm

Author

MS Neonatologie, Aubert, Adrien M., Costa, Raquel, Johnson, Samantha, Aden, U., Cuttini, M., Koopman-Esseboom, C., Lebeer, Jo, Varendi, H., Zemlin, Michael, Pierrat, V., Zeitlin, Jennifer, the SHIPS Research group, MS Neonatologie, Aubert, Adrien M., Costa, Raquel, Johnson, Samantha, Aden, U., Cuttini, M., Koopman-Esseboom, C., Lebeer, Jo, Varendi, H., Zemlin, Michael, Pierrat, V., Zeitlin, Jennifer, and the SHIPS Research group

Published
2023

4. Health-related quality of life of children born very preterm : a multinational European cohort study

Author

Kim, Sung Wook, Andronis, Lazaros, Seppänen, Anna-Veera, Aubert, Adrien M., Barros, Henrique, Draper, Elizabeth S., Sentenac, Mariane, Zeitlin, Jennifer, Petrou, Stavros, Lebeer, Jo, Van Reempts, Patrick, Bruneel, E., Cloet, E., Oostra, A., Ortibus, E., Sarrechia, Iemke, Boerch, K., Pedersen, P., Toome, L., Varendi, H., Männamaa, M., Ancel, P.Y., Burguet, A., Jarreau, P.H., Pierrat, V., Truffert, P., Maier, R.F., Zemlin, M., Misselwitz, B., Wohlers, L., Cuttini, M., Croci, I., Carnielli, V., Ancora, G., Faldella, G., Ferrari, F., van Heijst, A., Koopman-Esseboom, C., Gadzinowski, J., Mazela, J., Montgomery, A., Pikuła, T., Barros, H., Costa, R., Rodrigues, C., Aden, U., Draper, E.S., Fenton, A., Johnson, S.J., Mader, S., Thiele, N., Pfeil, J.M., Petrou, S., Kim, S.W., Andronis, L., Zeitlin, J., Aubert, A.M., Bonnet, C., El Rafei, R., Seppänen, A.V., and SHIPS Research Group

Subjects
RJ, Public Health, Environmental and Occupational Health, Human medicine, RG
Abstract

Purpose This study aims to (1) describe the health-related quality of life (HRQoL) outcomes experienced by children born very preterm (28–31 weeks’ gestation) and extremely preterm ( Methods This investigation was based on data for 3687 children born at ™ GCS scores. A mediation analysis that applied generalised structural equation modelling explored the association between potential mediators and PedsQL™ GCS scores. Results The multi-level OLS regression (fully adjusted model) revealed that birth at ™ GCS score of 0.35, 3.71 and 5.87, respectively. The mediation analysis revealed that the indirect effects of BPD and severe non-respiratory morbidity on the total PedsQL™ GCS score translated into decrements of 1.73 and 17.56, respectively, at Conclusion The findings suggest that HRQoL is particularly impaired by extremely preterm birth and the concomitant complications of preterm birth such as BPD and severe non-respiratory morbidity.

Published
2022

6. Two-year neurodevelopmental outcome in children born extremely preterm: the EPI-DAF study

Author

Beek, P.E. van, Rijken, M., Broeders, L., Horst, H.J. van der, Koopman-Esseboom, C., Kort, E. De, Laarman, C., Mulder-de Tollenaer, S.M., Steiner, K., Swarte, R.M., Westering-Kroon, E. van, Oei, S.G., Leemhuis, A.G., Andriessen, P., Beek, P.E. van, Rijken, M., Broeders, L., Horst, H.J. van der, Koopman-Esseboom, C., Kort, E. De, Laarman, C., Mulder-de Tollenaer, S.M., Steiner, K., Swarte, R.M., Westering-Kroon, E. van, Oei, S.G., Leemhuis, A.G., and Andriessen, P.

Abstract

Contains fulltext : 283154.pdf (Publisher’s version ) (Open Access), OBJECTIVE: In 2010, the Dutch practice regarding initiation of active treatment in extremely preterm infants was lowered from 25 completed weeks' to 24 completed weeks' gestation. The nationwide Extremely Preterm Infants - Dutch Analysis on Follow-up Study was set up to provide up-to-date data on neurodevelopmental outcome at 2 years' corrected age (CA) after this guideline change. Design: National cohort study. PATIENTS: All live born infants between 24(0/7) weeks' and 26(6/7) weeks' gestational age who were 2 years' CA in 2018-2020. MAIN OUTCOME MEASURE: Impairment at 2 years' CA, based on cognitive score (Bayley-III-NL), neurological examination and neurosensory function. RESULTS: 651 of 991 live born infants (66%) survived to 2 years' CA, with data available for 554 (85%). Overall, 62% had no impairment, 29% mild impairment and 9% moderate-to-severe impairment (further defined as neurodevelopmental impairment, NDI). The percentage of survivors with NDI was comparable for infants born at 24 weeks', 25 weeks' and 26 weeks' gestation. After multivariable analysis, severe brain injury and low maternal education were associated with higher odds on NDI. NDI-free survival was 48%, 67% and 75% in neonatal intensive care unit (NICU)-admitted infants at 24, 25 and 26 weeks' gestation, respectively. CONCLUSIONS: Lowering the threshold has not been accompanied by a large increase in moderate-to-severely impaired infants. Among live-born and NICU-admitted infants, an increase in NDI-free survival was observed from 24 weeks' to 26 weeks' gestation. This description of a national cohort with high follow-up rates gives an accurate description of the range of outcomes that may occur after extremely preterm birth.

Published
2022

7. Variation in term birthweight across European countries affects the prevalence of small for gestational age among very preterm infants

Author

Zeitlin, Jennifer, Bonamy, Anna‐Karin Edstedt, Piedvache, Aurelie, Cuttini, Marina, Barros, Henrique, Van Reempts, Patrick, Mazela, Jan, Jarreau, Pierre‐Henri, Gortner, Ludwig, Draper, Elizabeth S., Maier, Rolf F., Martens, E, Martens, G, Boerch, K, Hasselager, A, Huusom, L, Pryds, O, Weber, T, Toome, L, Varendi, H, Ancel, PY, Blondel, B, Burguet, A, Truffert, P, Misselwitz, B, Schmidt, S, Baronciani, D, Gargano, G, Agostino, R, DiLallo, D, Franco, F, Carnielli, V, Koopman‐Esseboom, C, Van Heijst, A, Nijman, J, Gadzinowski, J, Graça, LM, Machado, MC, Carrapato, MRG, Rodrigues, T, Norman, M, Wilson, E, Boyle, E, Manktelow, BN, Fenton, AC, Milligan, DWA, and Bonet, M

Published
2017
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8. Variability in the management and outcomes of extremely preterm births across five European countries: a population-based cohort study

Author

Smith, Lucy K, Blondel, Beatrice, Van Reempts, Patrick, Draper, Elizabeth S, Manktelow, Bradley N, Barros, Henrique, Cuttini, Marina, Zeitlin, Jennifer, Martens, E, Martens, G, Van Reempts, P, Boerch, K, Hasselager, A, Huusom, L, Pryds, O, Weber, T, Toome, L, Varendi, H, Ancel, PY, Blondel, B, Burguet, A, Jarreau, PH, Truffert, P, Maier, RF, Misselwitz, B, Schmidt, S, Gortner, L, Baronciani, D, Gargano, G, Agostino, R, DiLallo, D, Franco, F, Carnielli, V, Cuttini, M, Koopman-Esseboom, C, van Heijst, A, Nijman, J, Gadzinowski, J, Mazela, J, Graça, LM, Machado, MC, Rodrigues, Carina, Rodrigues, T, Bonamy, AK, Norman, M, Wilson, E, Boyle, E, Draper, ES, Manktelow, BN, Fenton, AC, Milligan, DWA, Zeitlin, J, Bonet, M, and Piedvache, A

Published
2017
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9. Changes in management policies for extremely preterm births and neonatal outcomes from 2003 to 2012: two population‐based studies in ten European regions

Author

Bonet, M, Cuttini, M, Piedvache, A, Boyle, EM, Jarreau, PH, Kollée, L, Maier, RF, Milligan, DWA, Van Reempts, P, Weber, T, Barros, H, Gadzinowki, J, Draper, ES, Zeitlin, J, Martens, E, Martens, G, Boerch, K, Hasselager, A, Huusom, L, Pryds, O, Ancel, PY, Blondel, B, Bréart, G, Gortner, L, Kuenzel, W, Misselwitz, B, Schmidt, S, Agostino, R, DiLallo, D, Franco, F, Paesano, R, Hukkelhoven, C, Hulscher, M, Koopman‐Esseboom, C, Van Heijst, A, Breborowicz, G, Gadzinowski, J, Mazela, J, Carrapato, M, Rodrigues, T, Konje, J, Manktelow, BN, Fenton, A, and Sturgiss, S

Published
2017
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13. Ultrasound markers for prediction of complex gastroschisis and adverse outcome: longitudinal prospective nationwide cohort study

Author

Lap, C.C.M.M. (C. C.M.M.), Pistorius, L.R., Mulder, E.J.H., Aliasi, M. (M.), Kramer, W.L.M., Bilardo, C.M. (Caterina Maddalena), Cohen-Overbeek, T.E. (Titia), Pajkrt, E. (Eva), Tibboel, D. (Dick), Wijnen, R.M.H. (René), Visser, G.H. (Gerhard Henk), Manten, G.T.R. (Gwendolyn), Bax, C.J. (Caroline), Baren, R. (Robertine) van, Brouwers, H.A. (Hens), Dijk, P.H. (Peter), Kaam, A.H. (Anton) van, Koopman-Esseboom, C. (Corine), Sikkel, E. (E.), Haak, M.C. (Monique), Heijst, A.F.J. (Arno) van, van der Hoeven, A.F. (A. F.), van Heurn, E.L. (E. L.), Sleeboom, C. (C.), Weissenbruch, M.M. (Mirjam) van, Willekes, C. (Christine), Lap, C.C.M.M. (C. C.M.M.), Pistorius, L.R., Mulder, E.J.H., Aliasi, M. (M.), Kramer, W.L.M., Bilardo, C.M. (Caterina Maddalena), Cohen-Overbeek, T.E. (Titia), Pajkrt, E. (Eva), Tibboel, D. (Dick), Wijnen, R.M.H. (René), Visser, G.H. (Gerhard Henk), Manten, G.T.R. (Gwendolyn), Bax, C.J. (Caroline), Baren, R. (Robertine) van, Brouwers, H.A. (Hens), Dijk, P.H. (Peter), Kaam, A.H. (Anton) van, Koopman-Esseboom, C. (Corine), Sikkel, E. (E.), Haak, M.C. (Monique), Heijst, A.F.J. (Arno) van, van der Hoeven, A.F. (A. F.), van Heurn, E.L. (E. L.), Sleeboom, C. (C.), Weissenbruch, M.M. (Mirjam) van, and Willekes, C. (Christine)

Abstract

Objectives: To identify antenatal ultrasound markers that can differentiate between simple and complex gastroschisis and assess their predictive value. Methods: This was a prospective nationwide study of pregnancies with isolated fetal gastroschisis that underwent serial longitudinal ultrasound examination at regular specified intervals between 20 and 37 weeks' gestation. The primary outcome was simple or complex (i.e. involving bowel atresia, volvulus, perforation or necrosis) gastroschisis at birth. Fetal biometry (abdominal circumference and estimated fetal weight), the occurrence of polyhydramnios, intra- and extra-abdominal bowel diameters and the pulsatility index (PI) of the superior mesenteric artery (SMA) were assessed. Linear mixed modeling was used to compare the individual trajectories of cases with simple and those with complex gastroschisis, and logistic regression analysis was used to estimate the strength of association between the ultrasound parameters and outcome. Results: Of 104 pregnancies with isolated fetal gastroschisis included, four ended in intrauterine death. Eighty-one (81%) liveborn infants with simple and 19 (19%) with complex gastroschisis were included in the analysis. We found no relationship between fetal biometric variables and complex gastroschisis. The SMA-PI was significantly lower in fetuses with gastroschisis than in healthy controls, but did not differentiate between simple and complex gastroschisis. Both intra- and extra-abdominal bowel diameters were larger in cases with complex, compared to those with simple, gastroschisis (P < 0.001 and P < 0.005, respectively). The presence of intra-abdominal bowel diameter ≥ 97.7th percentile on at least three occasions, not necessarily on successive examinations, was associated with an increased risk of the fetus having complex gastroschisis (relative risk, 1.56 (95% CI, 1.02–2.10); P = 0.006; positive predictive value, 50.0%; negative predictive value, 81.4%). Conclusions: This large

Published
2020
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14. Cohort study from 11 European countries highlighted differences in the use and efficacy of hypothermia prevention strategies after very preterm birth

Author

Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., Instituto de Saúde Pública, and Intituto de Saúde Pública

Subjects
Male, Hyperthermia, Pediatrics, medicine.medical_specialty, Delivery rooms, Hypothermia prevention, Hypothermia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Intensive care, medicine, Humans, Very Preterm Birth, Pediatrics, Perinatology, and Child Health, 030212 general & internal medicine, business.industry, European study, Infant, Newborn, Gestational age, General Medicine, medicine.disease, Perinatology, 3. Good health, and Child Health, Europe, Perinatal Care, Pediatrics, Perinatology and Child Health, Hypothermia - Prevention, Gestation, Female, Neonatal intensive care, medicine.symptom, business, Infant, Premature, Very preterm birth, Cohort study
Abstract

Aim: This study investigated the different strategies used in 11 European countries to prevent hypothermia, which continues to affect a large proportion of preterm births in the region. Methods: We examined the association between the reported use of hypothermia prevention strategies in delivery rooms and body temperatures on admission to neonatal intensive care units (NICUs) in 5861 infants born at 22 + 0 to 31 +6 weeks of gestation. The use of plastic bags, wraps, caps, exothermic heat and mattresses was investigated. Results: The proportion of infants born in units that systematically used one or more hypothermia prevention strategies was 88.2% and 50.9% of those infants were hypothermic on admission to NICUs. Of the 9.6% born in units without systematic hypothermia prevention, 73.2% were hypothermic. Only 2.2% of infants were born in units with no reported prevention strategies. Lower gestational age increased the probability of hypothermia. No significant differences were found between the various hypothermia prevention strategies. Hyperthermia was seen in 4.8% of all admitted infants. Conclusion: Very preterm infants had lower risks of hypothermia on NICU admission if the unit used systematic prevention strategies. All the strategies had similar effects, possibly due to implementation rather than a strategy's specific efficacy.

Published
2018
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16. Changes in management policies for extremely preterm births and neonatal outcomes from 2003 to 2012: two population-based studies in ten European regions

Author

Marques-Bonet, T., Cuttini, Marina, Piedvache, A., Boyle, Elaine M., Jarreau, Pierre Henri, Kollée, Louis A A, Maier, Rolf F., Milligan, David W A, van Reempts, P., Weber, Tom, Barros, Henrique, Gadzinowki, J., Draper, E. S., Zeitlin, Jennifer, Martens, E., Martens, Guy, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Pryds, Ole, Ancel, Pierre Yves, Blondel, Beatrice, Bréart, G., Gortner, Ludwig, Kuenzel, W., Misselwitz, Bjoern, Schmidt, S., Agostino, Rocco, DiLallo, D., Franco, Francesco, Paesano, R., Hukkelhoven, C., Hulscher, M., Koopman-Esseboom, C., van Heijst, A., Breborowicz, G., Gadzinowski, Janusz, Mazela, Jan, Carrapato, M., Ribeiro-Rodrigues, Teresa, Konje, J., Manktelow, B. N., Fenton, A. C., Sturgiss, S., and Mosaic EPICE Res Grp

Subjects
Male, Pediatrics, medicine.medical_specialty, Maternal-Child Health Services, medicine.medical_treatment, Population, Infant, Premature, Diseases, 03 medical and health sciences, 0302 clinical medicine, McNemar's test, Obstetrics and gynaecology, Pregnancy, 030225 pediatrics, Infant Mortality, Obstetrics and Gynaecology, neonatal intensive care, Journal Article, Humans, Medicine, Caesarean section, Hospital Mortality, 030212 general & internal medicine, education, Ethics, education.field_of_study, Chi-Square Distribution, business.industry, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Infant, Newborn, Infant, Obstetrics and Gynecology, Gestational age, extremely preterm births, Delivery, Obstetric, Organizational Policy, 3. Good health, Europe, Distress, Logistic Models, Infant, Extremely Premature, Premature Birth, Female, Human medicine, business, Live birth, Hospital Units, Demography, Cohort study
Abstract

Item does not contain fulltext OBJECTIVE: To investigate changes in maternity and neonatal unit policies towards extremely preterm infants (EPTIs) between 2003 and 2012, and concurrent trends in their mortality and morbidity in ten European regions. DESIGN: Population-based cohort studies in 2003 (MOSAIC study) and 2011/2012 (EPICE study) and questionnaires from hospitals. SETTING: 70 hospitals in ten European regions. POPULATION: Infants born at

Published
2017

18. Wide variation in severe neonatal morbidity among very preterm infants in European regions

Author

Bonamy, Anna Karin Edstedt, Zeitlin, Jennifer, Piedvache, Aurelie, Maier, Rolf F., van Heijst, Arno, Varendi, Heili, Manktelow, Bradley N., Fenton, Alan, Mazela, Jan, Cuttini, Marina, Norman, Mikael, Petrou, Stavros, Van Reempts, Patrick, Barros, Henrique, Draper, Elizabeth S., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graca, L. M., Machado, M. C., Rodrigues, Carina, Rodrigues, T., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W. A., Zeitlin, J., Bonet, M., Piedvache, A., and Epice Res Grp

Subjects
macromolecular substances, Human medicine
Abstract

Objective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. Design Area-based cohort study of all births before 32 weeks of gestational age. Setting 16 regions in 11 European countries in 2011/2012. Patients Survivors to discharge from neonatal care (n=6422). Main outcome measures Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades >= 3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. Results 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P< 0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P= 0.50). Conclusion Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.

Published
2019

19. Wide variation in severe neonatal morbidity among very preterm infants in european regions

Author

Edstedt Bonamy, Anna-Karin, Zeitlin, Jennifer, Piedvache, Aurelie, Maier, Rolf F., Van Heijst, Arno, Varendi, Heili, Manktelow, Bradley N., Fenton, Alan, Mazela, Jan, Cuttini, Marina, Norman, Mikael, Petrou, Stavros, Van Reempts, Patrick, Barros, Henrique, Draper, Elizabeth S., Martens, E., Martens, G., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, Tom, Toome, Liis, Ancel, Pierre-Yves, Blondel, Béatrice, Burguet, Antoine, Jarreau, Pierre-Henri, Truffert, Patrick, Schmidt, S., Gortner, Ludwig, Baronciani, D., Gargano, G., Agostino, R., Dilallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Nijman, J., Gadzinowski, Janusz, Graca, L. M., Machado, M. C., Rodrigues, Carina, Rodrigues, T., Wilson, Emilija, Boyle, Eileen Mary, Milligan, D. W. A., Bonet, Mercedes, Karolinska Institutet [Stockholm], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Philipps Universität Marburg = Philipps University of Marburg, Radboud University Medical Center [Nijmegen], University of Tartu, University of Leicester, Newcastle University [Newcastle], IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Poznan University of Medical Sciences [Poland] (PUMS), University of Warwick [Coventry], University of Antwerp (UA), Universidade do Porto = University of Porto, Hvidovre Hospital, Université Paris Descartes - Paris 5 (UPD5), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Saarland University [Saarbrücken], Istituto Nazionale di Riposo e Cura per Anziani di Ancona, University Medical Center [Utrecht], Université de Lisbonne, Hospital de São João [Porto], Karolinska University Hospital [Stockholm], Royal Victoria Hospital, McGill University Health Center [Montreal] (MUHC), Université de Lille, LillOA, Philipps University of Marburg, Universidade do Porto, and Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille

Subjects
Male, [SDV]Life Sciences [q-bio], Gestational Age, Infant, Premature, Diseases, macromolecular substances, Severity of Illness Index, neonatology, Cohort Studies, Pregnancy, Infant Mortality, Humans, Hospital Mortality, Prospective Studies, Reproductive History, Infant, Newborn, Infant, mortality, Europe, Pregnancy Complications, [SDV] Life Sciences [q-bio], Infant, Extremely Premature, Female, Original Article, epidemiology, Morbidity
Abstract

International audience; OBJECTIVE: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates.METHODS: Area-based cohort study of all births before 32 weeks of gestational age.METHODS: 16 regions in 11 European countries in 2011/2012.METHODS: Survivors to discharge from neonatal care (n=6422).METHODS: Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics.RESULTS: 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%-23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P

Published
2019
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20. Wide variation in severe neonatal morbidity among very preterm infants in european regions

Author

Edstedt Bonamy, A-K. (Anna-Karin), Zeitlin, J. (Jennifer), Piedvache, A. (Aurelie), Maier, R.F. (Rolf F.), Van Heijst, A. (Arno), Varendi, H. (Heili), Manktelow, B.N. (Bradley N.), Fenton, A. (Alan), Mazela, J. (Jan), Cuttini, M. (Marina), Norman, M. (Mikael), Petrou, S. (Stavros), Van Reempts, P. (Patrick), Barros, H. (Henrique), Draper, E.S. (Elizabeth S.), Martens, E. (E.), Martens, G. (G.), Boerch, K. (K.), Hasselager, A. (A.), Huusom, L. (L.), Pryds, O. (O.), Weber, T. (Tom), Toome, L. (Liis), Ancel, P-Y. (Pierre-Yves), Blondel, B. (Béatrice), Burguet, A. (Antoine), Jarreau, P-H. (Pierre-Henri), Truffert, P. (Patrick), Schmidt, S. (S.), Gortner, L. (Ludwig), Baronciani, D. (D.), Gargano, G. (G.), Agostino, R. (R.), Dilallo, D. (D.), Franco, F. (F.), Carnielli, V. (V.), Koopman-Esseboom, C. (C.), Nijman, J. (J.), Gadzinowski, J. (Janusz), Graca, L.M. (L. M.), Machado, M.C. (M. C.), Rodrigues, C. (Carina), Rodrigues, T. (T.), Wilson, E. (Emilija), Boyle, E.M. (Eileen Mary), Milligan, D.W.A. (D. W. A.), Bonet, M. (Mercedes), CHU Lille, Université de Lille, Karolinska Institutet [Stockholm], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)], Radboud University Medical Center [Nijmegen], University of Tartu, University of Leicester, Newcastle University [Newcastle], IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Poznan University of Medical Sciences [Poland] [PUMS], University of Warwick [Coventry], University of Antwerp [UA], Hvidovre Hospital, Université Paris Descartes - Paris 5 [UPD5], CHU Dijon, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Saarland University [Saarbrücken], Istituto Nazionale di Riposo e Cura per Anziani di Ancona, University Medical Center [Utrecht], Université de Lisbonne, Hospital de São João [Porto], Karolinska University Hospital [Stockholm], and Royal Victoria Hospital

Abstract

OBJECTIVE: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. METHODS: Area-based cohort study of all births before 32 weeks of gestational age. METHODS: 16 regions in 11 European countries in 2011/2012. METHODS: Survivors to discharge from neonatal care (n=6422). METHODS: Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. RESULTS: 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%-23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P

Published
2019

21. Low breastfeeding continuation to 6 months for very preterm infants: A European multiregional cohort study

Author

MS Neonatologie, Arts-assistenten Kinderen, Bonnet, Camille, Blondel, Béatrice, Piedvache, Aurélie, Wilson, Emilija, Bonamy, Anna Karin Edstedt, Gortner, L., Rodrigues, Carina, van Heijst, Arno, Draper, Elizabeth S., Cuttini, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., the EPICE Research Group, MS Neonatologie, Arts-assistenten Kinderen, Bonnet, Camille, Blondel, Béatrice, Piedvache, Aurélie, Wilson, Emilija, Bonamy, Anna Karin Edstedt, Gortner, L., Rodrigues, Carina, van Heijst, Arno, Draper, Elizabeth S., Cuttini, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., and the EPICE Research Group

Published
2019

22. Neurodevelopmental outcomes at five years after early-onset fetal growth restriction: Analyses in a Dutch subgroup participating in a European management trial

Author

Kinderbewegingszorg patientenzorg, Brain, MS Neonatologie, UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Pels, A., Knaven, O. C., Wijnberg-Williams, B. J., Eijsermans, M. J.C., Mulder-de Tollenaer, S. M., Aarnoudse-Moens, C. S.H., Koopman-Esseboom, C., van Eyck, J., Derks, J. B., Ganzevoort, W., van Wassenaer-Leemhuis, A. G., Kinderbewegingszorg patientenzorg, Brain, MS Neonatologie, UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Pels, A., Knaven, O. C., Wijnberg-Williams, B. J., Eijsermans, M. J.C., Mulder-de Tollenaer, S. M., Aarnoudse-Moens, C. S.H., Koopman-Esseboom, C., van Eyck, J., Derks, J. B., Ganzevoort, W., and van Wassenaer-Leemhuis, A. G.

Published
2019

23. The Effects on Mammals of Pre- and Postnatal Environmental Exposure to PCBs1 The Dutch Collaborative PCB/Dioxin Study

Author

Smits-van Prooije, A. E., primary, Waalkens-Berendsen, D. H., additional, Morse, D. C., additional, Koopman-Esseboom, C., additional, Huisman, M., additional, Sauer, P. J. J., additional, Boersma, E. R., additional, Lammers, J. H. C. M., additional, van den Berg, K. J., additional, van der Paauw, G. C., additional, Kulig, B. M., additional, and Snoeij, N. J., additional

Published
1996
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24. Neurodevelopmental Outcomes at Five Years After Early-Onset Fetal Growth Restriction: Analyses in a Dutch Subgroup Participating in a European Management Trial

Author

Pels, A., primary, Knaven, O. C., additional, Wijnberg-Williams, B. J., additional, Eijsermans, M. J. C., additional, Mulder-de Tollenaer, S. M., additional, Aarnoudse-Moens, C. S. H., additional, Koopman-Esseboom, C., additional, van Eyck, J., additional, Derks, J. B., additional, Ganzevoort, W., additional, and van Wassenaer-Leemhuis, A. G., additional

Published
2019
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25. Cohort study from 11 European countries highlighted differences in the use and efficacy of hypothermia prevention strategies after very preterm birth

Author

MS Neonatologie, Intensive care patientenzorg, Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., the EPICE Research Group, MS Neonatologie, Intensive care patientenzorg, Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., and the EPICE Research Group

Published
2018

27. [Two-year follow-up of infants born at 24 weeks gestation; first outcomes following implementation of the new 'Guideline for perinatal policy in cases of extreme prematurity']

Author

Aarnoudse-Moens, C.S.H., Rijken, M., Swarte, R.M., Andriessen, P., Horst, H.J. van der, Tollenaer, S.M. Mulder-de, Koopman-Esseboom, C., Laarman, A.R.C., Steiner, K., Hoeven, A. van der, Kornelisse, R.F., Duvekot, J.J., and Weisglas-Kuperus, N.

Subjects
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
Abstract

Item does not contain fulltext OBJECTIVE: Since 2010 the guideline 'Guideline for perinatal policy in cases of extreme prematurity' has advised an active policy in infants born at 24 weeks gestation. We investigated how infants born at 24 and 25 weeks gestation in the first year following the implementation of the guideline had developed by the age of 2 years. DESIGN: Retrospective national cohort study. METHOD: The study population consisted of all surviving infants born in the Netherlands at 24 or 25 weeks gestation in the period from 1 October 2010 to 1 October 2011. At a corrected age of 2 years the children underwent a general physical and neurological examination, and their cognitive scores were determined on the 'Bayley scales of infant and toddler development' (Bayley III). Examinations took place in the 10 neonatal intensive care units (NICU's) in the Netherlands. RESULTS: Of 185 extremely premature infants, 166 were admitted to a NICU. A total of 95 survived to a corrected age of 2 years; 78 (82%) children were examined. Their average cognitive score on the Bayley III scale was 88 (SD: 16). Among the children born at 24 weeks gestation, 20% had mild disabilities and 20% had moderate to severe disabilities. Among the children born at 25 weeks gestation, 17% had mild disabilities and 12% had moderate to severe disabilities. CONCLUSION: Of the children born at 24 weeks gestation in the first year after the introduction of active policy in the Netherlands and surviving to 2 years of age (46%), more than half had developed without disabilities. This was comparable to children born at 25 weeks gestation. Of all children born at 24 weeks gestation, 25% survived to 2 years of age without disabilities.

Published
2017

28. Use of magnesium sulfate before 32 weeks of gestation : A European population-based cohort study

Author

Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, and Bonet, M.

Subjects
Severity of Illness Index, Cohort Studies, 0302 clinical medicine, PREVENTIVE MEDICINE, Pre-Eclampsia, Pregnancy, Obstetrics and Gynaecology, Eclampsia, 030212 general & internal medicine, Practice Patterns, Physicians', reproductive and urinary physiology, Medicine(all), education.field_of_study, 030219 obstetrics & reproductive medicine, Evidence-Based Medicine, Obstetrics, Medical record, General Medicine, Calcium Channel Blockers, female genital diseases and pregnancy complications, 3. Good health, Europe, Pregnancy Trimester, Second, embryonic structures, Population study, Gestation, Premature Birth, Female, Guideline Adherence, Cohort study, Adult, medicine.medical_specialty, HELLP Syndrome, Population, Gestational Age, 03 medical and health sciences, Magnesium Sulfate, Young Adult, Intensive care, medicine, Journal Article, Humans, education, Fetus, business.industry, Research, fungi, medicine.disease, equipment and supplies, business
Abstract

Objectives: The use of magnesium sulfate (MgSO4) in European obstetric units is unknown. We aimed to describe reported policies and actual use of MgSO4 in women delivering before 32 weeks of gestation by indication. Methods: We used data from the European Perinatal Intensive Care in Europe (EPICE) population-based cohort study of births before 32 weeks of gestation in 19 regions in 11 European countries. Data were collected from April 2011 to September 2012 from medical records and questionnaires. The study population comprised 720 women with severe preeclampsia, eclampsia or HELLP and 3658 without preeclampsia delivering from 24 to 31 weeks of gestation in 119 maternity units with 20 or more very preterm deliveries per year. Results: Among women with severe pre-eclampsia, eclampsia or HELLP, 255 (35.4%) received MgSO4 before delivery. 41% of units reported use of MgSO4 whenever possible for pre-eclampsia and administered MgSO4 more often than units reporting use sometimes. In women without pre-eclampsia, 95 (2.6%) received MgSO4. 9 units (7.6%) reported using MgSO4 for fetal neuroprotection whenever possible. In these units, the median rate of MgSO4 use for deliveries without severe pre-eclampsia, eclampsia and HELLP was 14.3%. Only 1 unit reported using MgSO4 as a first-line tocolytic. Among women without preeclampsia, MgSO4 use was not higher in women hospitalised before delivery for preterm labour. Conclusions: Severe pre-eclampsia, eclampsia or HELLP are not treated with MgSO4 as frequently as evidence-based medicine recommends. MgSO4 is seldom used for fetal neuroprotection, and is no longer used for tocolysis. To continuously lower morbidity, greater attention to use of MgSO4 is needed.

Published
2017
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29. Variation in term birth weight across European countries affects the prevalence of small for gestational age among very preterm infants

Author

Zeitlin, Jennifer, Bonamy, Anna Karin Edstedt, Piedvache, Aurelie, Cuttini, Marina, Barros, Henrique, Van Reempts, Patrick, Mazela, Jan, Jarreau, Pierre Henri, Gortner, Ludwig, Draper, Elizabeth S., Maier, Rolf F., Martens, E., Martens, Guy, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Pryds, Ole, Weber, Tom, Toome, Liis, Varendi, Heili, Ancel, Pierre Yves, Blondel, Beatrice, Burguet, Antoine, Truffert, P., Misselwitz, Bjoern, Schmidt, S., Baronciani, Dante, Gargano, G., Agostino, Rocco, DiLallo, D., Franco, Francesco, Carnielli, Virgilio, Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, Janusz, Graça, Luis M., Ceu Machado, Maria, Carrapato, M. R.G., Ribeiro-Rodrigues, Teresa, Norman, Mikael, Wilson, E., Boyle, Elaine M., Manktelow, B. N., Fenton, A. C., Milligan, David W A, Marques-Bonet, T., Instituto de Saúde Pública, and EPICE Res Grp

Subjects
Male, Percentile, medicine.medical_specialty, Birthweight, Pediatrics, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Intensive care, Prevalence, Journal Article, medicine, Birth Weight, Humans, Pediatrics, Perinatology, and Child Health, reproductive and urinary physiology, National data, Fetal Growth Retardation, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, Infant, Newborn, Growth restriction, General Medicine, Intrauterine growth, Small for gestational age, medicine.disease, Perinatology, Europe, and Child Health, Very preterm, Very preterm infants, Intrauterine growth references, Infant, Small for Gestational Age, Pediatrics, Perinatology and Child Health, Cohort, Term Birth, Gestation, Female, Human medicine, business, Infant, Premature
Abstract

Aim This study assessed the prevalence of small for gestational age (SGA) among very preterm (VPT) infants using national and European intrauterine references. Methods We generated country-specific and common European intrauterine growth references for 11 European countries, according to Gardosi's approach and Hadlock's fetal growth model, by using national data on birth weights by sex. These references were applied to the Effective Perinatal Intensive Care in Europe (EPICE) cohort, which comprised 7,766 live VPT births without severe congenital anomalies under 32 weeks of gestation in 2011-12, to estimate the prevalence of infants with SGA birth weights, namely those below the 10th percentile. Results The SGA prevalence was 31.8% with country-specific references and 34.0% with common European references. The European references yielded a 10-point difference in the SGA prevalence between countries with lower term birth weights (39.9%) - Portugal, Italy and France - and higher term birth weights, namely Denmark, Netherlands, Sweden (28.9%) (p

Published
2017

30. Follow-up na 2 jaar van kinderen geboren bij 24 weken : Tit

Author

Aarnoudse-Moens, C S H, Rijken, M, Swarte, R M, Andriessen, P, Ter Horst, H J, Mulder-de Tollenaer, S M, Koopman-Esseboom, C, Laarman, A R C, Steiner, K, van der Hoeven, A H B M, Kornelisse, R F, Duvekot, J J, and Weisglas-Kuperus, N

Subjects
Journal Article, English Abstract
Abstract

OBJECTIVE: Since 2010 the guideline 'Guideline for perinatal policy in cases of extreme prematurity' has advised an active policy in infants born at 24 weeks gestation. We investigated how infants born at 24 and 25 weeks gestation in the first year following the implementation of the guideline had developed by the age of 2 years. DESIGN: Retrospective national cohort study. METHOD: The study population consisted of all surviving infants born in the Netherlands at 24 or 25 weeks gestation in the period from 1 October 2010 to 1 October 2011. At a corrected age of 2 years the children underwent a general physical and neurological examination, and their cognitive scores were determined on the 'Bayley scales of infant and toddler development' (Bayley III). Examinations took place in the 10 neonatal intensive care units (NICU's) in the Netherlands. RESULTS: Of 185 extremely premature infants, 166 were admitted to a NICU. A total of 95 survived to a corrected age of 2 years; 78 (82%) children were examined. Their average cognitive score on the Bayley III scale was 88 (SD: 16). Among the children born at 24 weeks gestation, 20% had mild disabilities and 20% had moderate to severe disabilities. Among the children born at 25 weeks gestation, 17% had mild disabilities and 12% had moderate to severe disabilities. CONCLUSION: Of the children born at 24 weeks gestation in the first year after the introduction of active policy in the Netherlands and surviving to 2 years of age (46%), more than half had developed without disabilities. This was comparable to children born at 25 weeks gestation. Of all children born at 24 weeks gestation, 25% survived to 2 years of age without disabilities.

Published
2017

31. Ultrasound markers for prediction of complex gastroschisis and adverse outcome: longitudinal prospective nationwide cohort study.

Author

Lap, C. C. M. M., Pistorius, L. R., Mulder, E. J. H., Aliasi, M., Kramer, W. L. M., Bilardo, C. M., Cohen‐Overbeek, T. E., Pajkrt, E., Tibboel, D., Wijnen, R. M. H., Visser, G. H. A., Manten, G. T. R., Bax, C. J., van Baren, R., Brouwers, H. A. A., Dijk, P. H., van Kaam, A. H., Koopman‐Esseboom, C., Sikkel, E., and Haak, M. C.

Subjects
GASTROSCHISIS, FETAL ultrasonic imaging, FORECASTING, COHORT analysis, PHYSICS, PREDICTIVE tests, POLYHYDRAMNIOS, DIFFERENTIAL diagnosis, REGRESSION analysis, MESENTERIC artery, GESTATIONAL age, RISK assessment, PERINATAL death, LOGISTIC regression analysis, ABDOMEN, BIOMETRY, LONGITUDINAL method, INTESTINES
Abstract

Objectives: To identify antenatal ultrasound markers that can differentiate between simple and complex gastroschisis and assess their predictive value.Methods: This was a prospective nationwide study of pregnancies with isolated fetal gastroschisis that underwent serial longitudinal ultrasound examination at regular specified intervals between 20 and 37 weeks' gestation. The primary outcome was simple or complex (i.e. involving bowel atresia, volvulus, perforation or necrosis) gastroschisis at birth. Fetal biometry (abdominal circumference and estimated fetal weight), the occurrence of polyhydramnios, intra- and extra-abdominal bowel diameters and the pulsatility index (PI) of the superior mesenteric artery (SMA) were assessed. Linear mixed modeling was used to compare the individual trajectories of cases with simple and those with complex gastroschisis, and logistic regression analysis was used to estimate the strength of association between the ultrasound parameters and outcome.Results: Of 104 pregnancies with isolated fetal gastroschisis included, four ended in intrauterine death. Eighty-one (81%) liveborn infants with simple and 19 (19%) with complex gastroschisis were included in the analysis. We found no relationship between fetal biometric variables and complex gastroschisis. The SMA-PI was significantly lower in fetuses with gastroschisis than in healthy controls, but did not differentiate between simple and complex gastroschisis. Both intra- and extra-abdominal bowel diameters were larger in cases with complex, compared to those with simple, gastroschisis (P < 0.001 and P < 0.005, respectively). The presence of intra-abdominal bowel diameter ≥ 97.7th percentile on at least three occasions, not necessarily on successive examinations, was associated with an increased risk of the fetus having complex gastroschisis (relative risk, 1.56 (95% CI, 1.02-2.10); P = 0.006; positive predictive value, 50.0%; negative predictive value, 81.4%).Conclusions: This large prospective longitudinal study found that intra-abdominal bowel dilatation when present repeatedly during fetal development can differentiate between simple and complex gastroschisis; however, the positive predictive value is low, and therefore the clinical usefulness of this marker is limited. © 2019 Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Preterm brain injury on term-equivalent age MRI in relation to perinatal factors and neurodevelopmental outcome at two years

Author

Brouwer, Margaretha J, Kersbergen, Karina J, van Kooij, Britt J M, Benders, Manon J N L, van Haastert, Ingrid C, Koopman-Esseboom, C, Neil, Jeffrey J, de Vries, Linda S, Kidokoro, Hiroyuki, Inder, Terrie E, Groenendaal, Floris, Brouwer, Margaretha J, Kersbergen, Karina J, van Kooij, Britt J M, Benders, Manon J N L, van Haastert, Ingrid C, Koopman-Esseboom, C, Neil, Jeffrey J, de Vries, Linda S, Kidokoro, Hiroyuki, Inder, Terrie E, and Groenendaal, Floris

Published
2017

33. Evidence-based neonatal unit practices and determinants of Postnatal corticosteroid-use in preterm births below 30 weeks ga in Europe : A population-based cohort study

Author

Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., Piedvache, A., Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., and Piedvache, A.

Published
2017

34. Follow-up na 2 jaar van kinderen geboren bij 24 weken: Tit

Author

MS Verloskunde, Arts-assistenten DV&B, Global Health, MS Neonatologie, Aarnoudse-Moens, C S H, Rijken, M, Swarte, R M, Andriessen, P, Ter Horst, H J, Mulder-de Tollenaer, S M, Koopman-Esseboom, C, Laarman, A R C, Steiner, K, van der Hoeven, A H B M, Kornelisse, R F, Duvekot, J J, Weisglas-Kuperus, N, MS Verloskunde, Arts-assistenten DV&B, Global Health, MS Neonatologie, Aarnoudse-Moens, C S H, Rijken, M, Swarte, R M, Andriessen, P, Ter Horst, H J, Mulder-de Tollenaer, S M, Koopman-Esseboom, C, Laarman, A R C, Steiner, K, van der Hoeven, A H B M, Kornelisse, R F, Duvekot, J J, and Weisglas-Kuperus, N

Published
2017

35. Variation in term birthweight across European countries affects the prevalence of small for gestational age among very preterm infants

Author

MS Neonatologie, Arts-assistenten Kinderen, Zeitlin, Jennifer, Bonamy, Anna Karin Edstedt, Piedvache, Aurelie, Cuttini, Marina, Barros, Henrique, Van Reempts, Patrick, Mazela, Jan, Jarreau, Pierre Henri, Gortner, Ludwig, Draper, Elizabeth S., Maier, Rolf F., Martens, E., Martens, Guy, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Pryds, Ole, Weber, Tom, Toome, Liis, Varendi, Heili, Ancel, Pierre Yves, Blondel, Beatrice, Burguet, Antoine, Truffert, P., Misselwitz, Bjoern, Schmidt, S., Baronciani, Dante, Gargano, G., Agostino, Rocco, DiLallo, D., Franco, Francesco, Carnielli, Virgilio, Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, Janusz, Graça, Luis M., Ceu Machado, Maria, Carrapato, M. R.G., Ribeiro-Rodrigues, Teresa, Norman, Mikael, Wilson, E., Boyle, Elaine M., Manktelow, B. N., Fenton, A. C., Milligan, David W A, Marques-Bonet, T., the EPICE Research Group, MS Neonatologie, Arts-assistenten Kinderen, Zeitlin, Jennifer, Bonamy, Anna Karin Edstedt, Piedvache, Aurelie, Cuttini, Marina, Barros, Henrique, Van Reempts, Patrick, Mazela, Jan, Jarreau, Pierre Henri, Gortner, Ludwig, Draper, Elizabeth S., Maier, Rolf F., Martens, E., Martens, Guy, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Pryds, Ole, Weber, Tom, Toome, Liis, Varendi, Heili, Ancel, Pierre Yves, Blondel, Beatrice, Burguet, Antoine, Truffert, P., Misselwitz, Bjoern, Schmidt, S., Baronciani, Dante, Gargano, G., Agostino, Rocco, DiLallo, D., Franco, Francesco, Carnielli, Virgilio, Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, Janusz, Graça, Luis M., Ceu Machado, Maria, Carrapato, M. R.G., Ribeiro-Rodrigues, Teresa, Norman, Mikael, Wilson, E., Boyle, Elaine M., Manktelow, B. N., Fenton, A. C., Milligan, David W A, Marques-Bonet, T., and the EPICE Research Group

Published
2017

36. Changes in management policies for extremely preterm births and neonatal outcomes from 2003 to 2012: two population-based studies in ten European regions

Author

MS Neonatologie, Marques-Bonet, T., Cuttini, Marina, Piedvache, A., Boyle, Elaine M., Jarreau, Pierre Henri, Kollée, Louis A A, Maier, Rolf F., Milligan, David W A, van Reempts, P., Weber, Tom, Barros, Henrique, Gadzinowki, J., Draper, E. S., Zeitlin, Jennifer, Martens, E., Martens, Guy, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Pryds, Ole, Ancel, Pierre Yves, Blondel, Beatrice, Bréart, G., Gortner, Ludwig, Kuenzel, W., Misselwitz, Bjoern, Schmidt, S., Agostino, Rocco, DiLallo, D., Franco, Francesco, Paesano, R., Hukkelhoven, C., Hulscher, M., Koopman-Esseboom, C., van Heijst, A., Breborowicz, G., Gadzinowski, Janusz, Mazela, Jan, Carrapato, M., Ribeiro-Rodrigues, Teresa, Konje, J., Manktelow, B. N., Fenton, A. C., Sturgiss, S., the MOSAIC and EPICE research groups, MS Neonatologie, Marques-Bonet, T., Cuttini, Marina, Piedvache, A., Boyle, Elaine M., Jarreau, Pierre Henri, Kollée, Louis A A, Maier, Rolf F., Milligan, David W A, van Reempts, P., Weber, Tom, Barros, Henrique, Gadzinowki, J., Draper, E. S., Zeitlin, Jennifer, Martens, E., Martens, Guy, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Pryds, Ole, Ancel, Pierre Yves, Blondel, Beatrice, Bréart, G., Gortner, Ludwig, Kuenzel, W., Misselwitz, Bjoern, Schmidt, S., Agostino, Rocco, DiLallo, D., Franco, Francesco, Paesano, R., Hukkelhoven, C., Hulscher, M., Koopman-Esseboom, C., van Heijst, A., Breborowicz, G., Gadzinowski, Janusz, Mazela, Jan, Carrapato, M., Ribeiro-Rodrigues, Teresa, Konje, J., Manktelow, B. N., Fenton, A. C., Sturgiss, S., and the MOSAIC and EPICE research groups

Published
2017

37. Preterm brain injury on term-equivalent age MRI in relation to perinatal factors and neurodevelopmental outcome at two years

Author

MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Brouwer, Margaretha J, Kersbergen, Karina J, van Kooij, Britt J M, Benders, Manon J N L, van Haastert, Ingrid C, Koopman-Esseboom, C, Neil, Jeffrey J, de Vries, Linda S, Kidokoro, Hiroyuki, Inder, Terrie E, Groenendaal, Floris, MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Brouwer, Margaretha J, Kersbergen, Karina J, van Kooij, Britt J M, Benders, Manon J N L, van Haastert, Ingrid C, Koopman-Esseboom, C, Neil, Jeffrey J, de Vries, Linda S, Kidokoro, Hiroyuki, Inder, Terrie E, and Groenendaal, Floris

Published
2017

38. Use of magnesium sulfate before 32 weeks of gestation: A European population-based cohort study

Author

MS Neonatologie, Brain, Arts-assistenten Kinderen, Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Bonet, M., MS Neonatologie, Brain, Arts-assistenten Kinderen, Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, and Bonet, M.

Published
2017

39. Evidence-based neonatal unit practices and determinants of Postnatal corticosteroid-use in preterm births below 30 weeks ga in Europe: A population-based cohort study

Author

MS Neonatologie, Brain, Arts-assistenten Kinderen, Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., Piedvache, A., MS Neonatologie, Brain, Arts-assistenten Kinderen, Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., and Piedvache, A.

Published
2017

40. Use of magnesium sulfate before 32 weeks of gestation:A European population-based cohort study

Author

Wolf, H. T., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Wolf, H. T., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., and Fenton, A. C.

Abstract

Objectives: The use of magnesium sulfate (MgSO4) in European obstetric units is unknown. We aimed to describe reported policies and actual use of MgSO4 in women delivering before 32 weeks of gestation by indication. Methods: We used data from the European Perinatal Intensive Care in Europe (EPICE) population-based cohort study of births before 32 weeks of gestation in 19 regions in 11 European countries. Data were collected from April 2011 to September 2012 from medical records and questionnaires. The study population comprised 720 women with severe preeclampsia, eclampsia or HELLP and 3658 without preeclampsia delivering from 24 to 31 weeks of gestation in 119 maternity units with 20 or more very preterm deliveries per year. Results: Among women with severe pre-eclampsia, eclampsia or HELLP, 255 (35.4%) received MgSO4 before delivery. 41% of units reported use of MgSO4 whenever possible for pre-eclampsia and administered MgSO4 more often than units reporting use sometimes. In women without pre-eclampsia, 95 (2.6%) received MgSO4. 9 units (7.6%) reported using MgSO4 for fetal neuroprotection whenever possible. In these units, the median rate of MgSO4 use for deliveries without severe pre-eclampsia, eclampsia and HELLP was 14.3%. Only 1 unit reported using MgSO4 as a first-line tocolytic. Among women without preeclampsia, MgSO4 use was not higher in women hospitalised before delivery for preterm labour. Conclusions: Severe pre-eclampsia, eclampsia or HELLP are not treated with MgSO4 as frequently as evidence-based medicine recommends. MgSO4 is seldom used for fetal neuroprotection, and is no longer used for tocolysis. To continuously lower morbidity, greater attention to use of MgSO4 is needed.

Published
2017

41. Cost-effectiveness of embryo transfer strategies: a decision analytic model using long-term costs and consequences of singletons and multiples born as a consequence of IVF

Author

Heesch, M.M. van, Asselt, A.D. van, Evers, J.L., Hoeven, M.A. van der, Dumoulin, J.C., Beijsterveldt, C.E. van, Bonsel, G.J., Dykgraaf, R.H., Goudoever, J.B. van, Koopman-Esseboom, C., Nelen, W.L.D.M., Steiner, K., Tamminga, P., Tonch, N., Torrance, H.L., Dirksen, C.D., Heesch, M.M. van, Asselt, A.D. van, Evers, J.L., Hoeven, M.A. van der, Dumoulin, J.C., Beijsterveldt, C.E. van, Bonsel, G.J., Dykgraaf, R.H., Goudoever, J.B. van, Koopman-Esseboom, C., Nelen, W.L.D.M., Steiner, K., Tamminga, P., Tonch, N., Torrance, H.L., and Dirksen, C.D.

Abstract

Item does not contain fulltext, STUDY QUESTION: What is the cost-effectiveness of elective single embryo transfer (eSET) versus double embryo transfer (DET) strategies from a societal perspective, when applying a time horizon of 1, 5 and 18 years? SUMMARY ANSWER: From a short-term perspective (1 year) it is cost-effective to replace DET with single embryo transfer; however when intermediate- (5 years) and long-term (18 years) costs and consequences are incorporated, DET becomes the most cost-effective strategy, given a ceiling ratio of euro20 000 per quality-adjusted life years (QALY) gained. WHAT IS ALREADY KNOWN: According to previous cost-effectiveness research into embryo transfer strategies, DET is considered cost-effective if society is willing to pay around euro20 000 for an extra live birth. However, interpretation of those studies is complicated, as those studies fail to incorporate long-term costs and outcomes and used live birth as a measure of effectiveness instead of QALYs. With this outcome, both multiple and singletons were valued as one live birth, whereas costs of all children of a multiple were incorporated. STUDY DESIGN, SIZE, DURATION: A Markov model (cycle length: 1 year; time horizon: 1, 5 and 18 years) was developed comparing a maximum of: (i) three cycles of eSET in all patients; (ii) four cycles of eSET in all patients; (iii) five cycles of eSET in all patients; (iv) three cycles of standard treatment policy (STP), i.e. eSET in women <38 years with a good quality embryo, and DET in all other women; and (v) three cycles of DET in all patients. PARTICIPANTS/MATERIALS, SETTING, METHODS: Expected life years (LYs), child QALYs and costs were estimated for all comparators. Input parameters were derived from a retrospective cohort study, in which hospital resource data were collected (n=580) and a parental questionnaire was sent out (431 respondents). Probabilistic sensitivity analysis (5000 iterations) was performed. MAIN RESULTS AND THE ROLE OF CHANCE: With a time horizon of 18

Published
2016

42. Cost-effectiveness of embryo transfer strategies : a decision analytic model using long-term costs and consequences of singletons and multiples born as a consequence of IVF

Author

van Heesch, M M J, van Asselt, A D I, Evers, J L H, van der Hoeven, M A H B M, Dumoulin, J C M, van Beijsterveldt, C E M, Bonsel, G J, Dykgraaf, R H M, van Goudoever, J B, Koopman-Esseboom, C, Nelen, W L D M, Steiner, K, Tamminga, P, Tonch, N, Torrance, H L, Dirksen, C D, van Heesch, M M J, van Asselt, A D I, Evers, J L H, van der Hoeven, M A H B M, Dumoulin, J C M, van Beijsterveldt, C E M, Bonsel, G J, Dykgraaf, R H M, van Goudoever, J B, Koopman-Esseboom, C, Nelen, W L D M, Steiner, K, Tamminga, P, Tonch, N, Torrance, H L, and Dirksen, C D

Published
2016

43. Cost-effectiveness of embryo transfer strategies: a decision analytic model using long-term costs and consequences of singletons and multiples born as a consequence of IVF

Author

Geboortecentrum voorzitterschap, Other research (not in main researchprogram), MS Neonatologie, Brain, Fertiliteitartsen, Child Health, van Heesch, M M J, van Asselt, A D I, Evers, J L H, van der Hoeven, M A H B M, Dumoulin, J C M, van Beijsterveldt, C E M, Bonsel, G J, Dykgraaf, R H M, van Goudoever, J B, Koopman-Esseboom, C, Nelen, W L D M, Steiner, K, Tamminga, P, Tonch, N, Torrance, H L, Dirksen, C D, Geboortecentrum voorzitterschap, Other research (not in main researchprogram), MS Neonatologie, Brain, Fertiliteitartsen, Child Health, van Heesch, M M J, van Asselt, A D I, Evers, J L H, van der Hoeven, M A H B M, Dumoulin, J C M, van Beijsterveldt, C E M, Bonsel, G J, Dykgraaf, R H M, van Goudoever, J B, Koopman-Esseboom, C, Nelen, W L D M, Steiner, K, Tamminga, P, Tonch, N, Torrance, H L, and Dirksen, C D

Published
2016

44. Cost-effectiveness of embryo transfer strategies: a decision analytic model using long-term costs and consequences of singletons and multiples born as a consequence of IVF

Author

van Heesch, M.M.J., primary, van Asselt, A.D.I, additional, Evers, J.L.H., additional, van der Hoeven, M.A.H.B.M., additional, Dumoulin, J.C.M., additional, van Beijsterveldt, C.E.M., additional, Bonsel, G.J., additional, Dykgraaf, R.H.M., additional, van Goudoever, J.B., additional, Koopman-Esseboom, C., additional, Nelen, W.L.D.M., additional, Steiner, K., additional, Tamminga, P., additional, Tonch, N., additional, Torrance, H.L., additional, and Dirksen, C.D., additional

Published
2016
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45. Hospital costs during the first 5 years of life for multiples compared with singletons born after IVF or ICSI

Author

Heesch, M.M. van, Evers, J.L., Hoeven, M.A. van der, Dumoulin, J.C., Beijsterveldt, C.E. van, Bonsel, G.J., Dykgraaf, R.H., Goudoever, J.B. van, Koopman-Esseboom, C., Nelen, W.L.D.M., Steiner, K., Tamminga, P., Tonch, N., Torrance, H.L., Dirksen, C.D., Heesch, M.M. van, Evers, J.L., Hoeven, M.A. van der, Dumoulin, J.C., Beijsterveldt, C.E. van, Bonsel, G.J., Dykgraaf, R.H., Goudoever, J.B. van, Koopman-Esseboom, C., Nelen, W.L.D.M., Steiner, K., Tamminga, P., Tonch, N., Torrance, H.L., and Dirksen, C.D.

Abstract

Item does not contain fulltext, STUDY QUESTION: Do in vitro fertilization (IVF) multiples generate higher hospital costs than IVF singletons, from birth up to age 5? SUMMARY ANSWER: Hospital costs from birth up to age 5 were significantly higher among IVF/ICSI multiple children compared with IVF/ICSI singletons; however, when excluding the costs incurred during the birth admission period, hospital costs of multiples and singletons were comparable. WHAT IS KNOWN ALREADY: Concern has risen over the long-term outcome of children born after IVF. The increased incidence of multiple births in IVF as a result of double-embryo transfer predisposes children to a poorer neonatal outcome such as preterm birth and low birthweight. As a consequence, IVF multiples require more medical care. Costs and consequences of poorer neonatal outcomes in multiples may also exist later in life. STUDY DESIGN, SIZE, DURATION: All 5497 children born from IVF in 2003-2005, whose parents received IVF or ICSI treatment in one of five participating Dutch IVF centers, served as a basis for a retrospective cohort study. Based on gestational age, birthweight, Apgar and congenital malformation, children were assigned to one of three risk strata (low-, moderate- or high-risk). PARTICIPANTS/MATERIALS, SETTING, METHODS: To enhance the efficiency of the data collection, 816 multiples and 584 singletons were selected for 5-year follow-up based on stratified (risk) sampling. Parental informed consent was received of 322 multiples and 293 singletons. Individual-level hospital resource use data (hospitalization, outpatient visits and medical procedures) were retrieved from hospital information systems and patient charts for 302 multiples and 278 singletons. MAIN RESULTS AND THE ROLE OF CHANCE: The risk of hospitalization (OR 4.9, 95% CI 3.3-7.0), outpatient visits (OR 2.6, 95% CI 1.8-3.6) and medical procedures (OR 1.7, 95% CI 1.2-2.2) was higher for multiples compared with singletons. The average hospital costs amounted to euro10 018 and eu

Published
2015

46. Hospital costs during the first 5 years of life for multiples compared with singletons born after IVF or ICSI

Author

Van Heesch, M. M J, Evers, J. L H, Van Der Hoeven, M. A H B M, Dumoulin, J. C M, Van Beijsterveldt, C. E M, Bonsel, G. J., Dykgraaf, R. H M, Van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L D M, Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., Dirksen, C. D., Van Heesch, M. M J, Evers, J. L H, Van Der Hoeven, M. A H B M, Dumoulin, J. C M, Van Beijsterveldt, C. E M, Bonsel, G. J., Dykgraaf, R. H M, Van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L D M, Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., and Dirksen, C. D.

Published
2015

47. Hospital costs during the first 5 years of life for multiples compared with singletons born after IVF or ICSI

Author

Fertiliteitartsen, Child Health, CTI Leusen, Geboortecentrum voorzitterschap, MS Neonatologie, Van Heesch, M. M J, Evers, J. L H, Van Der Hoeven, M. A H B M, Dumoulin, J. C M, Van Beijsterveldt, C. E M, Bonsel, G. J., Dykgraaf, R. H M, Van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L D M, Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., Dirksen, C. D., Fertiliteitartsen, Child Health, CTI Leusen, Geboortecentrum voorzitterschap, MS Neonatologie, Van Heesch, M. M J, Evers, J. L H, Van Der Hoeven, M. A H B M, Dumoulin, J. C M, Van Beijsterveldt, C. E M, Bonsel, G. J., Dykgraaf, R. H M, Van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L D M, Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., and Dirksen, C. D.

Published
2015

48. Perinatal mortality and mode of delivery in monochorionic diamniotic twin pregnancies >= 32 weeks of gestation: a multicentre retrospective cohort study

Author

Hack, K.E.A., Derks, J.B., Elias, S.G., Mameren, F.A. van, Koopman-Esseboom, C., Mol, B.W.J., Lopriore, E., Schaap, A.H.P., Arabin, B., Duvekot, J.J., Go, A.T.J.I., Wieselmann, E., Eggink, A.J., Willekes, C., Vandenbussche, F.P.H.A., Visser, G.H.A., Obstetrics and gynaecology, ICaR - Ischemia and repair, Obstetrie & Gynaecologie, RS: GROW - School for Oncology and Reproduction, APH - Amsterdam Public Health, and Obstetrics and Gynaecology

Subjects
optimal time of delivery, Cardiovascular diseases [NCEBP 14], Female preponderance in twins, mode of delivery, perinatal mortality, twin, monochorionic, pregnancy, Cardiovascular diseases Glycostation disorders [NCEBP 14]
Abstract

Item does not contain fulltext OBJECTIVE: To study perinatal mortality rates in a cohort of 465 monochorionic (MC) twins without twin-twin transfusion syndrome (TTS) born at 32 weeks of gestation or later since reported interauterine fetal death (IUFD) rates >32 weeks of gestations in the literature vary, leading to varying recommendations on the optimal timing of delivery, and to investigate the relation between perinatal mortality and mode of delivery. DESIGN: Multicentre retrospective cohort study. SETTING: Ten perinatal referral centres in the Netherlands. POPULATION: All MC twin pregnancies without TTTS delivered at >/= 32 weeks of gestation between January 2000 and December 2005. METHODS: The medical records of all MC twin pregnancies without TTTS delivered at the ten perinatal referral centres in the Netherlands between January 2000 and December 2005 were reviewed. MAIN OUTCOME MEASURES: Perinatal mortality in relation to gestational age and mode of delivery at >/= 32 weeks of gestation. RESULTS: After 32 weeks of gestation, five out of 930 fetuses died in utero and there were six neonatal deaths (6 per 1000 infants). In women who delivered >/= 37 weeks, perinatal mortality was 7 per 1000 infants. Trial of labour was attempted in 376 women and was successful in 77%. There were three deaths in deliveries with a trial of labour (8 per 1000 deliveries), of which two were related to mode of delivery. Infants born by caesarean section without labour had an increased risk of neonatal morbidity and respiratory distress syndrome. CONCLUSIONS: In MC twin pregnancies the incidence of intrauterine fetal death is low >/= 32 weeks of gestation. Therefore, planned preterm delivery before 36 weeks does not seem to be justified. The risk of intrapartum death is also low, at least in tertiary centres.

Published
2011

50. A comparison of perinatal outcomes in singletons and multiples born after in vitro fertilization or intracytoplasmic sperm injection stratified for neonatal risk criteria

Author

Heesch, M.M. van, Evers, J.L.H., Dumoulin, J.C., Hoeven, M.A. van der, Beijsterveldt, C.E. van, Bonsel, G.J., Dykgraaf, R.H., Goudoever, J.B. van, Koopman-Esseboom, C., Nelen, W.L.D.M., Steiner, K., Tamminga, P., Tonch, N., Zonneveld, P. van, Dirksen, C.D., Heesch, M.M. van, Evers, J.L.H., Dumoulin, J.C., Hoeven, M.A. van der, Beijsterveldt, C.E. van, Bonsel, G.J., Dykgraaf, R.H., Goudoever, J.B. van, Koopman-Esseboom, C., Nelen, W.L.D.M., Steiner, K., Tamminga, P., Tonch, N., Zonneveld, P. van, and Dirksen, C.D.

Abstract

Item does not contain fulltext, OBJECTIVE: To compare perinatal singleton and multiple outcomes in a large Dutch in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) population and within risk subgroups. Newborns were assigned to a risk category based on gestational age, birthweight, Apgar score and congenital malformation. DESIGN: Register-based retrospective cohort study. SETTING: Netherlands Perinatal Registry data. SAMPLE: A total of 3041 singletons and 1788 multiple children born from IVF/ICSI in 2003-2005. METHODS: Student's t-test or Mann-Whitney U-test was used to analyze continuous data, chi-squared analyses were used for categorical data. Multivariate logistic and linear regression analysis was performed to analyze whether the risk stratification criteria were associated with neonatal hospital admission and length of stay. MAIN OUTCOME MEASURES: Start of labor, mode of delivery, gestational age, birthweight, 5-min Apgar score, congenital malformation, neonatal hospital admission, neonatal intensive care unit admission and mortality. RESULTS: IVF/ICSI-conceived multiples had considerably poorer outcomes than singletons in terms of cesarean section rate, preterm birth, birthweight, being small-for-gestational-age, Apgar score, neonatal hospital admission, neonatal intensive care unit admission and neonatal mortality. As opposed to the results found in the total study population and the low-risk and moderate-risk populations, high-risk multiples showed better outcomes than high-risk singletons regarding cesarean section rate, birthweight and Apgar score. All risk stratification variables were associated with being hospitalized after birth. Length of stay was associated with all risk stratification criteria except Apgar score. CONCLUSIONS: Perinatal outcomes in IVF/ICSI-conceived multiples are considerably poorer than in singletons. This finding mainly pertains to low-risk children. High-risk multiples had significantly better perinatal outcomes than high-risk singletons.

Published
2014

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