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WOS:000435647500034 Aim: This research was performed on patients diagnosed with chronic obstructive pulmonary disease (COPD) in Sirnak province center to explore the relation between COPD and blood types. Material and Method: Pulmonary function tests were performed on 1000 patients over the age of 30 who were randomly selected from the patients residing in the city center of Sirnak. 570 (57%) of the participants were male and 430 (43%) were female. Results: When combined with the Global Obstructive Lung Disease (GOLD) criteria, the prevalence of COPD was 10.1% (101 patients). Disease stages were mild in 1.98%; moderate in 27.72%; severe in 43.36%; and very severe in 26.74% of COPD patients. COPD was diagnosed in 11.92% (68 patients) of men and 7.67% (33 patients) of women participating in the study. The blood types of 93 patients with COPD from the group of 101 were retrospectively reached from hospital records. Patients were classified according to ABO blood type data. As a result, it was found that COPD was more common in patients with blood type A. According to ABO blood types distribution of our cases with COPD were as follows: 39 patients (42%) were type A, 26 patients (28%) were type B, 17 patients (18%) were type AB and 11 patients (12%) were type O. Discussion: A conclusion is reached revealing the association of blood type with COPD risk factors, which was mentioned in much of the corpus of medical literature. Amaç: Bu çalışma Şırnak il merkezinde kronik obstruktif akciğer hastalığı (KOAH) olan hastalarda KOAH ile kan grupları arasındaki ilişkiyi ortaya koymak amacıyla yapılmıştır. Gereç ve Yöntem: Şırnak il merkezinde oturan ve 30 yaş üzerinde olan 1000 hastada solunum fonksiyon testleri yapılmıştır. 570 hasta (%57) erkek, 430 hasta (%43) kadın idi. Bulgular: Global Obstruktif Akciğer Hastalığı (GOAH) kriterleri ile birlikte değerlendirildiğinde, KOAH prevalansı %10.1 (101 hasta) olarak saptandı. Hastalık evresi %1.98 hastada hafif, %27.72 hastada orta ve %43.56 hastada şiddetli ve %26.74 hastada ise çok şiddetli olarak saptandı. KOAH çalışmaya katılan erkeklerin %11.92’sinde (68 hasta), kadınların ise %7.67’sinde (33 hasta) saptandı. KOAH tanısı konulan 101 hastadan 93’ünün kan gruplarına hastane kayıtlarından ulaşıldı. Hastalar ABO kan gruplarına göre sınıflandırıldı. Sonuç olarak KOAH en sık olarak A kan grubunda saptandı. ABO kan gruplarına göre KOAH hastalığı olanlarda görülen gruplar şu şekilde idi: A kan grubunda 39 hasta (%42), B kan grubunda 26 hasta (%28), AB kan grubunda 17 hasta (%18) ve 0 kan grubunda ise 11 hasta (%12). Tartışma: Mevcut tıbbi literatürle uyumlu olarak KOAH hastalığı kan grupları ile ilişkili bulunmuştur.

WOS:000435647500022 Aim: Chronic Obstructive Pulmonary Disease (COPD) is increasingly recognized as a leading cause of global morbidity and mortality throughout the world. The prevalence and mortality of COPD have increased through years. This study was conducted to explore the prevalence of COPD in the central Bolu province of Turkey. Material and Method: Pulmonary function testing (PFT) was performed on 500 subjects above the age of 35 years who were selected randomly using 'Family Identification Cards' in each governor office in central Bolu. Of the 500 subjects, 285 (57.0%) were male. The diagnostic criteria of Global Initiative for Chronic Obstructive Lung Disease (GOLD) with spirometry was used to diagnose COPD. Results: The prevalence of COPD was found to be 8.6% (43 of 500 subjects). None of the diagnosed subjects had stage 1 disease in terms of GOLD stage definition. Stage 2, stage 3, and stage 4 diseases were found in 34.9%, 41.8%, and 23.3% of COPD-diagnosed subjects, respectively Smoking history was positive in 42 of 43 subjects with COPD (97.7%). In terms of all subjects, COPD was diagnosed in 9.8% of males (28 of 285) and 6.9% of females (15 of 215). Discussion: COPD was defined as a significant public health problem in Bolu province of Turkey. Amaç: Günümüzde Kronik Obstrüktif Akciğer Hastalığı (KOAH), tüm dünya ülkelerinde önemli bir sağlık sorunu haline gelmiştir. Diğer hastalıkların mortalite oranlarının yıllar içinde düşmesine karşılık KOAH prevalansı ve mortalitesi giderek artış göstermektedir. Bu araştırma Bolu il merkezinde KOAH prevalansını belirlemek amacıyla yapıldı. Material and Method: Bolu il merkezinde oturan, ev tespit fişlerinden rastgele yöntemle seçilen 35 yaş ve üstü 500 kişiye solunum fonksiyon testleri yapıldı. Çalışmaya katılan bireylerden 285’i (%57) erkek, 215’i (%43) kadın idi. KOAH’nın tanısı için ‘Obstruktif Akciğer hastalıkları için Global İnsiyatif’ kriterleri ile birlikte spirometri kullanıldı. Bulgular: KOAH prevalansı % 8.6 (43 kişi) bulundu. KOAH tespit edilen hastaların hiç biri hafif evrede değildi. % 34.9’i orta, % 41.86’sı ağır ve % 23.25’i çok ağır evrede idi. KOAH tespit edilen hastaların % 97.67’sinde (43 kişiden 42’sinde) sigara içme öyküsü vardı. Çalışmaya katılan erkeklerin % 9.82’sinde (285 kişiden 28 kişide), kadınların % 6,97’sinde (215v kişiden 15 kişide) KOAH saptandı. Tartışma: KOAH’ın, Bolu il merkezinde önemli bir halk sağlığı sorunu olduğu düşünüldü

WOS:000435647500029 Aim: To evaluate the extensity of two basic misperceptions in asthma patients. Material and Method: The patients over 18 years of age who had been diagnosed with asthma and using asthma drugs were enrolled in the study. The patients were consecutively selected who examined in the private office of the author. Participants have been asked whether 'asthma is a contagious disease' and whether 'asthma drugs cause addiction. Results: A total of 1,003 patients were included in the study. The ratios of patients who declared that 'asthma is a contagious disease' or 'asthma is not a contagious disease' were 15.3% and 58.0%, respectively. The ratio of patients who declared that 'asthma drugs cause addiction' and 'asthma drugs do not cause addiction were 17.9% and 27.0%. Discussion: Although most patients answers were in accordance with scientific facts, the ratios of misperception are thought to be high. Amaç: Astım hastalarında iki temel yanlış algının yaygınlığını değerlendirmek. Gereç ve Yöntem: 18 yaşından büyük, astım tanısı almış ve atım ilaçları kullanan hastalar çalışmaya alındı. Hastalar yazarın ofisine muayene olmak amacıyla gelen hastalar arasından sırası ile çalışmaya alındı. Hastalara ‘astım hastalığının bulaşıcı bir hastalık olup olmadığı ve astım ilaçlarının bağımlılık yapıp yapmadığı konularında sorular soruldu. Bulgular: Toplam 1003 hasta çalışmaya alındı. ‘Astım bulaşıcı bir hastalıktır’ ve ‘Astım bulaşıcı bir hastalık değildir’ yanıtını veren hastaların oranları sırası ile %15.3 ve %58.0 idi. ‘Astım ilaçları bağımlılık yapar’ ve ‘Astım ilaçları bağımlılık yapmaz’ şeklinde cevap veren hastaların oranları ise sırası ile %17.9 and %27.0 idi. Tartışma: Hastaların büyük kısmı mevcut bilimsel gerçeklere uygun cevap vermişlerse de verilen yanlış cevap oranlarının yüksek olduğunu değerlendiriyoruz

Conclusion: The findings suggested that smoking prevalence can be high and nicotine addiction can be common among elementary school-aged children (age interval: 6-14 years) in Sirnak in Turkey, in addition to demonstrating that these children can easily access tobacco without experiencing any difficulties.

Günümüzde Kronik Obstrüktif Akciğer Hastalığı (KOAH), tüm dünya ülkelerinde önemli bir sağlık sorunu haline gelmiştir. Diğer hastalıkların mortalite oranlarının yıllar içinde düşmesine karşılık KOAH prevalansı ve mortalitesi giderek artış göstermektedir. Bu araştırma Bolu il merkezinde KOAH prevalansını belirlemek amacıyla yapıldı. Bolu il merkezinde oturan, ev tespit fişlerinden rastgele yöntemle seçilen 35 yaş ve üstü 500 kişiye solunum fonksiyon testi yapıldı. Çalışmaya katılan bireylerden 285'i (%57) erkek, 215'i (%43) kadın idi. Solunum fonksiyon testi ?The Global Initiative for Chronic Obstructive Lung Disease? (GOLD) kriterleri ile birlikte değerlendirildiğinde KOAH prevalansı %8.6 (43 kişi) bulundu. KOAH tespit edilen hastaların hiç biri hafif evrede değildi. %34.88'i orta, %41.86'sı ağır ve %23.25'i çok ağır evrede idi. KOAH tespit edilen hastaların %97.67'sinde sigara içme öyküsü vardı. Çalışmaya katılan erkeklerin %9.82'sinde (28 kişi), kadınların %6,97'sinde (15 kişi) KOAH saptandı. Sonuç olarak KOAH'ın, Bolu il merkezinde önemli bir halk sağlığı sorunu olduğu düşünüldü. Chronic Obstructive Pulmonary Disease (COPD) is increasingly recognized as a leading cause of global morbidity and mortality. In this study, we aimed to investigate COPD prevalence in Bolu province of Turkey. Adult population over 35 living in central Bolu was enrolled to the study. They were selected according to random methods based on regional inhabitant listings. 500 adult persons were finally enrolled to the study. Of 500, 285 (57%) were males and 215 (43%) were females. Spirometry was evaluated according to GOLD criteria. COPD prevalence was found as 8.6% (n:43). GOLD Stage distribution of COPD cases were as follows: None was in mild stage. 34.9%, 41.9% and 23.3% of COPD patients was in moderate, severe and very severe stage,spectively. 97.7% of COPD patients had a smoking history. COPD prevalence was 9.82% (n:28) in male COPD patients, and 6.9% (n:15) in female patients. In conclusion, COPD is an important public health problem in central Bolu province. 73

The aim of this study was finding out the rates of pneumococcal and influenza vaccination, the factors influencing vaccination, and non-vaccination in COPD patients.The study was conducted with 104 COPD patients diagnosed by a pulmonologist. The diagnosis was made according to the GOLD 2019 document via an FEV1/FVC ratio below 70%. The patients were inquired about getting vaccinated for influenza in the last year and pneumococci in the last five years. The patients were then grouped according to their vaccination status and inquired about their perception of the necessity of vaccination. The study revealed a significant association between COPD levels and the awareness of the necessity of annual influenza vaccination (p=0.019). However, there was no significant association between COPD levels and being vaccinated for influenza in the last year (p=0.434). There was no significant association between COPD levels and pneumococcal vaccination in the last five years or the awareness for the necessity of the vaccine (p=0.0559 and p=0.495). 22.2% of the patients who were vaccinated for pneumonia were also vaccinated for influenza and 98.7% of the patients who were not vaccinated for pneumonia were also not vaccinated for influenza in the last year. 85.7% of the patients who got an influenza vaccine in the last year also knew the necessity of getting annually vaccinated (p=

The oxidant-antioxidant imbalance is an important factor in the pathogenesis of COPD and yet there is a lack of evidence about total antioxidant levels of COPD patients, which may provide valuable information about the prognosis of the disease. In this study, we aimed to evaluate and compare the oxidant-antioxidant systems in healthy controls and in COPD patients with a stable disease and during an acute exacerbation. The study was conducted with 42 COPD patients diagnosed by a pulmonologist and 21 healthy volunteers. Pulmonary function tests were performed, arterial blood gas; white blood cell, hemoglobin, hematocrit, platelet, neutrophil%, MCV, CRP, and sedimentation rate results were compared with total antioxidant status, total oxidant status levels, and oxidative stress index. There was a statistically significant difference between the three groups in FEV1/FVC, FEV1, FVC, pCO2, pO2, % SpO2, white blood cell count, neutrophil %, CRP, and ESR values. In regard to oxidant-antioxidant system measurements there was no statistically significant difference in TAS levels, but there was a significant difference in TOS and oxidative stress index levels. Positive correlation between WBC and TOS was detected in the analysis performed and no correlation was found in other parameters. Our study showed that the measurement of TAS, TOS and OSI were meaningful parameters in the evaluation of oxidative imbalance. Oxidant stress was found to be significantly increased in all COPD patients, especially in patients with COPD exacerbations. Despite the increase in oxidative stress, no increase in antioxidant levels was observed in COPD patients. [Med-Science 2020; 9(3.000): 609-13]

Bu çalışmaya, KOAH tanısıyla rastgele toplam 75 hasta dahil edildi. Çalışma grubundaki hastaların yaşı, cinsiyeti, eğitim durumu, yaşadığı yer, hastalık süresi,sigara içme durumu, ilacı tarif eden, göğüs hastalıkları tarafından takip durumu, kullanılan cihaz çeşidi, ilaçtan memnun olma durumu ve cihazı kullanırken yeterli inhalasyon, doğru nefes, ağız yıkama ve toplam skorları çalışmaya dahil edildi. Hastaların demografik özellikleri,inhaler cihazın kullanımı ile ilgili herhangi bir eğitim alıp almadığı ve aldıysa eğitimi kimin verdiği; inhalerin cihazların kullanım basamakları ile ilgili sorular içeren aynı zamanda hastaların cihaz kullanımı ile ilgili hangi aşamada ve neden hata yaptıklarını sorgulayan gözlem formu dolduruldu. Hastaların hastalık süresi, Göğüs Hastalıkları Uzmanı takibi ve cihaz çeşidine göre Cihaz kurulumu, yeterli inhalasyon, nefes tutma, ağız yıkama ve toplam skoruyla değerlendirilmesi yapıldı. In this study, A total of 75 patients with the diagnosis of COPD were randomly included. Age, gender, educational status, place of residence, duration of illness, smoking status, follow-up by pulmonologist, type of device used, satisfaction with the drug, adequate inhalation, correct breathing, mouth washing and total scores were included in the study. The demographic characteristics of the patients, whether they received any training on the use of the inhaler device, and if so, who provided the training; The questionnaire was filled with questions about the usage steps of the inhaler and questions about the stage of the device usage and why they made mistakes. Patients were evaluated according to disease duration, follow-up the pulmonologist, and device installation, adequate inhalation, breath holding, mouth washing and total score. 82

Aim. We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS). Materials and Method. 44 patients with OSAS and 44 healthy adults were included in this study. The participants having rheumatic or systemic inflammatory disease, advanced liver or kidney failure, diabetes, heart failure, hypertension, pregnancy, prerenal azotemia, known history of coronary artery disease, any pulmonary disease, rhinitis, or atopy, history of major trauma or surgery within the last six 6 months, and inhaled nasal or systemic corticosteroid use or other anti-inflammatory medications and those with p<0.05 was considered as significant. Results. Serum PAPP-A levels of patients with OSAS (2.350 ng/ml (0.641–4.796)) were significantly higher (p<0.001) when compared with healthy controls (0.971 ng/ml (0.109–2.679)). There was a statistically significant difference in serum PAPP-A levels between groups of OSAS patients according to the classification of OSAS severity. Between the groups of patients with OSAS, serum levels of PAPP-A in moderate group was significantly higher when compared with severe OSAS group (p<0.001). There was positive correlations between PAPP-A levels and night minimum (p=0.042, r=0.309), and average oxygen levels (p=0.006, r=0.407). There was a negative correlation between PAPP-A levels and AHI (p=0.002, r=−0.460). Conclusion. Higher PAPP-A levels in OSAS patients that were found in this study show inflammatory component in OSAS.