64 results on '"Kontaş O"'
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2. Evaluation of contralateral testicular damage after unilateral testicular torsion by serum inhibin B levels
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Özkan, K.U., Küçükaydin, M., Muhtaroğlu, S., and Kontaş, O.
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- 2001
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3. Protective effects of vitamin E and Gingko biloba extract on stress induced gastric mucosal injury in rats
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Çetin, M., Özbakir, O., Kontaş, O., Taşkapan, H., and Yücesoy, M.
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- 2000
4. PP-015 IMPACT ON PROGNOSIS OF K-RAS MUTATION AND C-MYC OVEREXPRESSION AT DIFFUSE LARGE B-CELL LYMPHOMAS
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Ertas, S. Ketenci, Inal, A., Keklik, M., Ozkul, Y., Akalin, H., Canoz, I., Kontas, O., Baran, M., Civgin, S., Kaynar, L., Eser, B., and Cetin, M.
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- 2014
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5. Rhinocerebral mucormycosis: experience in 14 patients.
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Ketenci, İ, Ünlü, Y, Kaya, H, Somdaş, M A, Kontaş, O, Öztürk, M, and Vural, A
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DIAGNOSIS ,DRUG therapy ,DIABETES ,LEUKEMIA ,MYCOSES ,OPPORTUNISTIC infections ,HEALTH outcome assessment ,PARANASAL sinus diseases ,OPERATIVE surgery ,TOMOGRAPHY ,CENTRAL nervous system infections ,TREATMENT effectiveness ,HEMATOLOGIC malignancies ,IMMUNOCOMPROMISED patients ,SYMPTOMS - Abstract
Objective:Mucormycosis is an opportunist, often lethal fungal infection which occurs in immunocompromised patients. We present our experience in 14 patients with this condition.Patients and methods:A retrospective chart review was conducted for 14 patients treated for rhinocerebral mucormycosis.Results:Nine patients had diabetes mellitus and six had a haematological malignancy. Nine patients had cutaneous and/or palatal necrosis. Eleven patients were treated with amphotericin B and five with liposomal amphotericin B. Endoscopic sinus surgery was performed in five patients with disease limited to the sinonasal cavity; nine patients underwent more extensive surgery. Five patients with disease limited to the sinonasal cavity survived, while nine patients with widely disseminated disease died. Five of the nine diabetic patients died, as did five of the six patients with haematological malignancy.Conclusion:Patients with rhinocerebral mucormycosis spreading outside the sinonasal cavity have a poor prognosis. [ABSTRACT FROM PUBLISHER]
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- 2011
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6. Cutaneous Polyarteritis Nodosa.
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Demirel BG, Utaş S, and Kontaş O
- Abstract
Copyright of Turkish Journal of Dermatology / Turk Dermatoloji Dergisis is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2010
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7. Cohen Syndrome with Acanthosis Nigricans and Insulin Resistance.
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Kumandaş, S., Gümüş, H., Kurtoglu, S., Elmas, B., and Kontaş, O.
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- 2001
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8. Determination of Nontoxic Concentrations of Piperacillin/Tazobactam for Intravitreal Application
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Özkiriş, A., Evereklioglu, C., Kontaş, O., Öner, A. Öztürk, and Erkiliç, K.
- Abstract
Abstract Background: To investigate the highest nontoxic intravitreal dose of piperacillin/tazobactam in rabbits. Material and Methods: Forty New Zealand white albino rabbits were used in this study. The rabbits were divided into four equal groups (10 rabbits in each) and the right eyes were treated with 0.1 ml intravitreal injections of 1,000 μg piperacillin/tazobactam in group 1, 500 μg in group 2, 250 μg in group 3, and 100 μg in group 4. The left eyes served as controls and were injected with 0.1 ml of saline solution. Ganzfeld electroretinogram (ERG) was performed on all eyes before and after 4 weeks of intravitreal injections. Then, the rabbits were killed and the eyes were enucleated for histopathological evaluation of the retina. Retinal sections were evaluated by morphometric analyses on cell counts of ganglion cell layer and thickness of the various retinal layers. Results: Baseline ERGs were similar among the groups (p > 0.05). After 4 weeks of injection, there were a reduction of the b-wave amplitude and extension of the b-wave implicit time in photopic and scotopic ERGs in group 1 and group 2 when compared with controls (for each, p < 0.001). Intravitreal injection of 100 and 250 μg piperacillin/tazobactam did not cause any deterioration of the b-wave of ERGs throughout the follow-up period of 4 weeks (for each, p > 0.05). After morphometric analysis of retinal sections in all groups, there were no statistically significant differences in the mean number of surviving ganglion cells, thickness of the whole retina and the inner plexiform layer compared with controls (p > 0.05). Conclusion: 250 μg/0.1 ml piperacillin/tazobactam is the highest nontoxic dose to the normal retinas of adult albino rabbits as intravitreal injection. Piperacillin/tazobactam may be a new, potentially important drug in the treatment of endophthalmitis as it has a broad antimicrobial spectrum.Copyright © 2004 S. Karger AG, Basel- Published
- 2004
9. Deep Sclerectomy with Various Implants: An Experimental and Histopathologic Study in a Rabbit Model
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Erkiliç, K., Özkiriş, A., Evereklioglu, C., Kontaş, O., Güler, K., and Dogan, H.
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Abstract Background and Objective: To investigate the effectiveness of various implants used in experimental deep sclerectomy and to report tissue reactions developed to these implants histopathologically. Materials and Methods: Forty eyes of 40 New Zealand white albino rabbits underwent deep sclerectomy with various implants. The rabbits were divided into four groups; each consisted of 10 eyes. Deep sclerectomy was performed using copolymer materials in group 1, silicone materials in group 2 and chromic catgut suture in group 3. No implants were used in the control group (group 4). Clinical and histopathological examinations were performed to investigate the effectiveness of implants. Results: Mean preoperative intraocular pressure (IOP) was 14.4 ± 1.6 mm Hg in group 1, 14.5 ± 1.8 mm Hg in group 2, 13.8 ± 1.5 mm Hg in group 3 and 14.5 ± 1.2 mm Hg in group 4. The final postoperative IOPs were 10.7 ± 0.9, 10.6 ± 0.8, 13.5 ± 1.0, and 14.5 ± 1.4 mm Hg, respectively. At 2 months, the decrease in IOPs from baseline and the persistence of the filtering bleb were significantly marked in group 1 and group 2 (p < 0.001). Histopathological evaluation revealed that copolymer and silicone materials formed a smooth and regular intrascleral space. There were no foreign body reaction, tissue destruction or fibrosis in group 1 and group 2, but chromic catgut sutures caused severe fibrosis and inflammatory reaction in group 3. Mean histopathologic score of group 1, group 2, group 3 and group 4 was 0.7 ± 0.5, 0.8 ± 0.5, 2.4 ± 0.6, and 0.1 ± 0.3, respectively. Conclusion: Copolymer or silicone materials may increase the success rate of surgery by maintenance of a large and regular intrascleral space after deep sclerectomy and prevention of collapse of the flap.Copyright © 2004 S. Karger AG, Basel- Published
- 2004
10. An epidermoid carcinoma case developed on old surgical scar in an epidermodysplasia verruciformis patient.
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Özyazgan, İ., KontaŞ, O., Gökahmetoglu, S., and Özkul, Y.
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LETTERS to the editor , *SKIN cancer - Abstract
A letter to the editor is presented in response to the article "An Epidermoid Carcinoma Case Developed on Old Surgical Scar in an Epidermodysplasia Verruciformis Patient" in the September 2005 issue.
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- 2005
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11. Primary brain T-cell lymphoma concomitant with CNS tuberculosis in a kidney transplant patient
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Sipahioǧlu, M., Altuntaş, F., Aybal, A., Ünal, A., Leylagul Kaynar, Kontaş, O., Oymak, O., and Utaş, C.
12. Ectopic salivary gland of the base of the tongue: A rare cause of neonatal respiratory distress
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Şahin, M. İ, ibrahim ketenci, Kökoğlu, K., Şan, F., Kara, İ, Öztürk, M. A., and Kontaş, O.
- Abstract
Neonatal upper airway obstruction is a life-threatening condition and requires rapid assessment and effective treatment. Malformations of the upper airway of a newborn can lead to acute respiratory distress. The aim of the present paper is to report the case of a newborn with respiratory distress due to a tongue base mass, which was removed surgically. The patient needed a tracheostomy tube for only three days and then could breathe spontaneously. However, he had swallowing problems, which decreased gradually over 9 months. Histopathologically, the mass was found to consist of mucous salivary glands, and was recorded as an ectopic salivary gland, which is extremely rare among the types of masses that may cause upper airway obstruction in a newborn.
13. PP15.8 – 2911: A rare cause of ptosis in four years old girl: Superior mediastinal malignant peripheral nevre sheath tumor.
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Canpolat, M., Kontaş, O., Özçora, G., Unal, E., Bayram, A.K., Küçükaydin, M., Görkem, S.B., Gümüş, H., Kumandaş, S., and Per, H.
- Abstract
Objective The falling of the upper eyelid is called ptosis. It has been classified five mainly group as; myogenic, neurogenic, mechanical, aponeurotic and pseudoptosis. The symptoms occur at the same side as the lesion of the sympathetic trunk. Malignant peripheral nerve sheath tumors (MPNSTs) develop from Schwann cells, perineural cells and neural fibroblasts. MPNSTs are heavily homogeneous tumors consisting only of nerve sheath cells or Schwann cells. It can occur in any peripheral or cranial nerve. It develops mostly on the cranial nerves, autonomic nerves, and flexor sites of limbs. Methods We reported a rare presentation of MPNST with ptosis. Results A four year old girl admitted to our outpatient department of neurology with complaint of left ptosis for the last one month. Her neurologic examination was normal except ptosis and only one café au lait macule which are smaller than 1 cm were detected. There was no history of systemic illness or trauma, nor was any familial history obtained. Chest X-ray examination revealed a mass lesion in the lung. Chest MRI showed a 44×26×40 mm sized paravertebral mass at the level of C7-T1. She was diagnosed as sympathetic ptosis due to this mass. Abdomen CT, laboratory tests and bone marrow aspiration were normal. The lesion was surgically removed by thoracoscopic approach. The histopathological examination was relevant with MPNST. Conclusion To the best of our knowledge, there have been no previous reports of isolated ptosis as the initial presenting sign of MPNST. It is important to evaluate the chest X-ray presented with complaint of ptosis in children. We recommend that pediatricians and pediatric neurologists perform meticulous investigation in terms of neoplasm or paraneoplastic syndrome in newly developing, persisting, or unexplained neurological signs. [ABSTRACT FROM AUTHOR]
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- 2015
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14. NOP02 Desmoplastic non-infantile ganglioglioma: case report.
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Per, H., Gümüş, H., Kontaş, O., Ekici, M.A., Kumandaş, S., and Kurtsoy, A.
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- 2007
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15. Case report: Cutaneous polyarteritis nodosa presenting with ulcers in atypical localizations and atypical skin rashes: A report of a rare case.
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Kökoğlu EO, Kontaş O, Kaplan H, Cengiz CB, and Şenel AS
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- Humans, Treatment Outcome, Skin pathology, Biopsy, Female, Male, Immunosuppressive Agents therapeutic use, Polyarteritis Nodosa diagnosis, Polyarteritis Nodosa drug therapy, Polyarteritis Nodosa complications, Skin Ulcer etiology, Skin Ulcer diagnosis, Skin Ulcer pathology, Exanthema etiology, Exanthema diagnosis
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- 2024
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16. The effect of danger-associated molecular patterns on survival in acute graft versus host disease.
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Çelik S, Kaynar L, Güven ZT, Atasever Duran K, Kontaş O, Keklik M, and Ünal A
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- Humans, Recurrence, Graft vs Host Disease etiology, Hematopoietic Stem Cell Transplantation adverse effects
- Abstract
Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the pathogenesis of graft versus host disease (GvHD). Uric acid (UA) and fibrinogen (Fib) are DAMPs released from damaged tissue during allogeneic hematopoietic stem cell transplantation (allo-HCT) and GvHD. We aimed to evaluate the effects of UA and Fib levels on survival in GvHD. One hundred seventy-four patients with grade 2-4 acute GvHD were included. UA and Fib levels were evaluated on allo-HCT day 0 and GvHD on days 0, 7, 14, and 28. Fib GvHD day 0 was the independent predictor for overall survival (OS), non-relapse mortality (NRM), and progression-free survival in multivariable models (HR 0.98, p < 0.001; HR 0.98, p = 0.001, HR 0.98, p = 0.006, respectively). Also UA GvHD day 28 was the independent predictor for OS and NRM (HR 0.77, p = 0.004; HR 0.76, p = 0.011, respectively). Our results indicated that hypouricemia and hypofibrinogenemia were associated with a significantly shorter OS and higher NRM. UA and Fib are remarkable molecules in GvHD because they are routinely utilized, readily available, can be therapeutic targets, and have DAMPs and antioxidant features., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
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- 2024
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17. The investigation of adrenal involvement in carbapenem resistant Acinetobacter baumannii sepsis: experimental mouse model
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Eryılmaz-Eren E, Dinç G, Kontaş O, Alp E, and Doğanay M
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- Acinetobacter Infections drug therapy, Animals, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Bacteremia drug therapy, Carbapenem-Resistant Enterobacteriaceae genetics, Corticosterone, Female, Mice, Microbial Sensitivity Tests, Sepsis drug therapy, Acinetobacter Infections microbiology, Acinetobacter baumannii drug effects, Acinetobacter baumannii isolation & purification, Adrenal Insufficiency microbiology, Carbapenems pharmacology, Sepsis microbiology
- Abstract
Background/aim: In the last years, incidence of carbapenem resistant Acinetobacter baumannii sepsis is increasing with high mortality. However, it is not clear whether this is due to inadequate antimicrobial choice or a more severe clinical course. We aimed to evaluate the inflammation and adrenal involvement in the carbapenem resistant A. baumannii by using experimental mouse model sepsis., Materials and Methods: Balb/c female mice were randomly put into control and three sepsis groups ( A. baumannii susceptible to carbapenem-CSAB-, A. baumannii resistant to carbapenem-CRAB-, Escherichia coli). A total of sixty mice were included in this study with each group having 15 mice. Mice were sacrificed 72 h after bacterial inoculation, and blood was taken from each mouse for the assessment of cytokines and corticosterone. Both adrenal glands were dissected; one was used for culture and the other was used for histopathological examination. Bacterial loads of organs were calculated as CFU/g. The histopathological changes, bacterial levels in adrenal and cytokine and corticosterone levels were assessed and compared among the groups., Results: The bacterial level was higher in E. coli (108, 45 ±30, 55 log10 CFU/g) (mean±SD) than other sepsis groups. The lowest level of corticosterone was observed in the E. coli group (p < 0.001). TNF alpha level was highest in the CRAB and E. coli group and this difference was statistically significant than control group (p < 0.05). The IL-6 level in CRAB was significantly higher than the control group (10, 20 pg/mL). The adrenal gland congestion was significantly severe in all the sepsis groups compared to the control. In the group comparison, congestion was significantly more severe in the E. coli group than in CSAB and CRAB groups., Conclusion: Adrenal involvement and inflammatory reactions are seen in E. coli sepsis and in CRAB sepsis. These findings will be focused on in future clinical trials., Competing Interests: The authors of this manuscript have no conflict of interests to declare., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
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- 2021
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18. Pleuropulmonary blastoma: A report of two cases.
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Demir ÖF, Önal Ö, Hasdıraz L, Oğuzkaya F, Kontaş O, and Ülgey A
- Abstract
Pleuropulmonary blastoma is a rare and aggressive childhood tumor of mesenchymal origin. It has a poor prognosis and mainly classified as cystic (type 1), mixed type (type 2), and solid (type 3). Herein, we present two cases of pleuropulmonary blastoma type 3 presenting with pneumothorax, a rare clinical presentation of pleuropulmonary blastoma, which was successfully treated with surgery., Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article., (Copyright © 2020, Turkish Society of Cardiovascular Surgery.)
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- 2020
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19. Clinical significance of progastrin-releasing peptide, neuron-specific enolase, chromogranin a, and squamous cell cancer antigen in pulmonary neuroendocrine tumors
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Tutar N, Yetkin NA, Yazıcı C, Önal Ö, Kontaş O, and Keleştemur F
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- Aged, Antigens, Neoplasm blood, Carcinoma, Non-Small-Cell Lung blood, Carcinoma, Non-Small-Cell Lung diagnosis, Carcinoma, Non-Small-Cell Lung epidemiology, Chromogranin A blood, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Recombinant Proteins blood, Serpins blood, Biomarkers, Tumor blood, Lung Neoplasms blood, Lung Neoplasms diagnosis, Lung Neoplasms epidemiology, Neuroendocrine Tumors blood, Neuroendocrine Tumors diagnosis, Neuroendocrine Tumors epidemiology, Peptide Fragments blood, Phosphopyruvate Hydratase blood
- Abstract
Background/aim: It is not always easy to diagnose pulmonary neuroendocrine tumors (PNETs). The aim of the present study is to make a differential diagnosis by studying the same markers in patients with non-small-cell lung carcinoma (NSCLC), patients with benign lung disease (chronic obstructive pulmonary disease and pneumonia), and healthy volunteers to determine the roles of these markers in pulmonary neuroendocrine tumor diagnosis and to identify their power., Materials and Methods: A total of 100 participants including 23 PNET patients and 28 NSCLC patients who were pathologically di-agnosed but not yet treated, 25 participants with benign disease, and 24 healthy volunteers were included in this cross-sectional study., Results: No significant difference was found between the chromogranin A (CgA) and squamous cell carcinoma antigen 1 (SCCA1) values among the groups (PNET, NSCLC, benign, healthy volunteers), but the difference in progesterone-releasing peptide (ProGRP), neuron-specific enolase (NSE), and adjusted NSE was statistically significant (P values were respectively ProGRP, P = 0.006; NSE, P = 0.015; NSE adjusted, P = 0.09). In a comparison of the PNET and NSCLC groups, having a ProGRP value higher than 84.6 pg/mL re-vealed PNET with 60.9% sensitivity and 89.3% specificity (P = 0.001)., Conclusion: The ProGRP value is the only indicator that distinguishes the PNET group from the other 3 groups., (This work is licensed under a Creative Commons Attribution 4.0 International License)
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- 2019
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20. Ectopic salivary gland of the base of the tongue: a rare cause of neonatal respiratory distress.
- Author
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Şahin Mİ, Ketenci İ, Kökoğlu K, Şan F, Kara İ, Öztürk MA, and Kontaş O
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- Humans, Infant, Newborn, Male, Choristoma complications, Respiratory Distress Syndrome, Newborn etiology, Salivary Glands, Tongue Diseases complications
- Abstract
Neonatal upper airway obstruction is a life-threatening condition and requires rapid assessment and effective treatment. Malformations of the upper airway of a newborn can lead to acute respiratory distress. The aim of the present paper is to report the case of a newborn with respiratory distress due to a tongue base mass, which was removed surgically. The patient needed a tracheostomy tube for only three days and then could breathe spontaneously. However, he had swallowing problems, which decreased gradually over 9 months. Histopathologically, the mass was found to consist of mucous salivary glands, and was recorded as an ectopic salivary gland, which is extremely rare among the types of masses that may cause upper airway obstruction in a newborn.
- Published
- 2014
21. Scabies mimicking mastocytosis in two infants.
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Cölgeçen-Özel E, Ertaş R, Utaş S, and Kontaş O
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- Diagnosis, Differential, Humans, Infant, Male, Mastocytosis diagnosis, Scabies diagnosis
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Scabies is a common parasitic human infection in infants and children. However, diagnostic pitfalls are frequent in infants, in whom the clinical presentation is usually atypical and different from that in adults. In nodular scabies, lesions may be clinically or histologically misdiagnosed as Langerhans cell histiocytosis, insect bite reaction, non-Langerhans cell histiocytosis, lymphoma, or urticaria pigmentosa. We report two misleading cases of young infants (10- and 12-month-old infants) who presented with pruritic brown-red lesions on their trunks and showing a positive Darier's sign, suggestive of urticaria pigmentosa.
- Published
- 2013
22. A report of a desmoplastic non-infantile ganglioglioma in a 6-year-old boy with review of the literature.
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Per H, Kontaş O, Kumandaş S, and Kurtsoy A
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- Child, Ganglioglioma surgery, Humans, Magnetic Resonance Imaging, Male, Neurosurgical Procedures, Supratentorial Neoplasms surgery, Ganglioglioma pathology, Supratentorial Neoplasms pathology
- Abstract
Desmoplastic infantile gangliogliomas (DIG) are uncommon supratentorial brain tumors with a usually good prognosis despite an aggressive radiological appearance that typically occurs in infants below the age of 24 months. DIGs are exclusively supratentorial, generally have a voluminous size, and are partially cystic. Total surgical removal is sufficient for the treatment of these tumors, and no chemotherapy or radiotherapy is indicated if complete resection is achieved. Except for age difference, DIG and desmoplastic non-infantile gangliogliomas are radiologically and histologically similar. Non-infantile variants of this biologically benign intracranial neoplasm are rare; only 15 cases of non-infantile DIGs have been reported in the literature. As far as we know, this case is the 16th in literature. We reported the magnetic resonance imaging and histological findings of desmoplastic ganglioglioma in a 6-year-old boy.
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- 2009
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23. Atypical intracerebral schwannoma mimicking glial tumor: case report.
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Menkü A, Oktem IS, Kontaş O, and Akdemir H
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- Adult, Biopsy, Brain Neoplasms complications, Brain Neoplasms surgery, Diagnosis, Differential, Epilepsy etiology, Epilepsy surgery, Humans, Male, Neurilemmoma complications, Neurilemmoma surgery, Astrocytoma pathology, Brain Neoplasms pathology, Epilepsy pathology, Magnetic Resonance Imaging, Neurilemmoma pathology
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A rare case of a solitary schwannoma arising within parenchyma of the brain is reported. A 37-year old right-handed man presented with a 3- month history of progressive headaches, lethargy and vomiting. The initial diagnosis being considered was primary intracranial tumor, including high-grade astrocytoma, metastasis or lymphoma Histopathological examination revealed schwannoma. Cysts, calcification and mild to moderate peritumoral edema are common in intracerebral schwannomas. However, our case is atypical and has no cystic component, calcification or vascularization. The pathogenesis and neuroradiological findings of intraparenchymal schwannomas are discussed and we review the related literature.
- Published
- 2009
24. Signet ring-like cells in pituitary adenoma.
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Deniz K, Tanriverdi F, Selçuklu A, Kontaş O, and Keleştimur F
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- Adenoma metabolism, Adenoma surgery, Adult, Chorionic Gonadotropin therapeutic use, Chromogranins metabolism, Clomiphene therapeutic use, Female, Fertility Agents, Female therapeutic use, Headache etiology, Humans, Immunohistochemistry, Infertility, Female drug therapy, Magnetic Resonance Imaging, Pituitary Neoplasms metabolism, Pituitary Neoplasms surgery, Synaptophysin metabolism, Vision Disorders etiology, Adenoma pathology, Pituitary Neoplasms pathology
- Abstract
We describe a case of non-functioning pituitary adenoma in a 35-year-old woman with a prior history of fertility problems. The patient had received clomiphen citrate and human chorionic gonadotrophin for 3 years. Histological examination of the tumor revealed signet ring-like cell areas admixed with minor conventional round-polygonal neoplastic cells. The two populations of tumor cells showed strong immunoreactivity for chromogranin and synaptophysin. The clinicopathologic features and diagnostic difficulties of this rare entity are discussed.
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- 2008
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25. Torticollis secondary to posterior fossa and cervical spinal cord tumors: report of five cases and literature review.
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Kumandaş S, Per H, Gümüş H, Tucer B, Yikilmaz A, Kontaş O, Coşkun A, and Kurtsoy A
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- Astrocytoma surgery, Child, Child, Preschool, Cranial Fossa, Posterior pathology, Craniotomy, Diagnosis, Differential, Eosinophilic Granuloma surgery, Ependymoma surgery, Female, Humans, Infratentorial Neoplasms surgery, Magnetic Resonance Imaging, Male, Neurosurgical Procedures, Spinal Cord pathology, Spinal Cord Neoplasms surgery, Tomography, X-Ray Computed, Torticollis pathology, Astrocytoma complications, Eosinophilic Granuloma complications, Ependymoma complications, Infratentorial Neoplasms complications, Spinal Cord Neoplasms complications, Torticollis etiology
- Abstract
Torticollis is either congenital or acquired in childhood. Acquired torticollis is not a diagnosis but rather a sign of an underlying disorder. The causes of acquired torticollis include ligamentous, muscular, osseous, ocular, psychiatric, and neurologic disorders and may be a symptom of significant abnormalities of the spinal cord and brain, such as spinal syrinx or central nervous system neoplasia. Torticollis is rarely considered to be an initial clinical presentation of posterior fossa and cervical spinal cord tumors. We report five cases of pediatric tumors with torticollis at the onset: an astrocytoma originating from the medulla oblongata, another presumptive astrocytoma of the spinal cord located between C1 and C6 cervical vertebrae (not operated), an ependymoma located throughout the whole cervical spinal cord extending into the bulbomedullary junction, an astrocytoma originating from the bulbus and extending into the posterior fossa, and another case of a eosinophilic granuloma located extradurally through the anterior and posterior portions of the vertebral bodies from C3 to C7 producing the collapse of the sixth cervical vertebra. All five cases were seen in children, aged between 3 and 12 years. All these cases reflect the misinterpretation of this neurological sign and the lack of association with the possibility of spinal or posterior fossa tumor. This delay in the diagnosis of these diseases led to progressive neurological deterioration and to the increase in the tumor size, which made surgical intervention difficult and the prognosis unfavorable. Although torticollis secondary to tumors is rarely seen, it is necessary to be kept in mind in the differential diagnosis.
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- 2006
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26. Effects of prenatal flutamide on testicular development, androgen production and fertility in rats.
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Okur H, Muhtaroğlu S, Bozkurt A, Kontaş O, Küçükaydin N, and Küçükaydin M
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- Animals, Male, Rats, Rats, Wistar, Androgen Antagonists pharmacology, Androgens biosynthesis, Fertility drug effects, Flutamide pharmacology, Testis drug effects, Testis growth & development
- Abstract
Introduction: To investigate the effects of blocking prenatal androgen with the anti-androgen flutamide on testicular weight (TW), seminiferous tubular diameter (STD), testicular biopsy score (TBS), testicular testosterone (TT), and fertility., Materials and Methods: Ten pregnant Wistar albino rats were injected with flutamide (100 mg/kg) on gestational days 16 and 19. Rats injected with the solvent were used as controls. Male pups from these dams were evaluated for testicular descent on postnatal day 22. The ability of each male to produce offspring was tested when the animals were aged 130 days. The rats were killed when 180 days old, and the testes were removed., Results: Sixteen of the 24 male rats (66.6%) exhibited cryptorchidism (6 unilateral, 10 bilateral) in the flutamide-treated group. Three of the rats with normally descended testicles were fertile, but none of the cryptorchid rats was fertile in flutamide-treated group. The average TW, mean STD, TBS and TT levels of the flutamide-treated rats was significantly lower than in the solvent-injected rats. However, there was no significant difference in these values between descended and undescended testes in flutamide-treated rats., Conclusion: Blocking of prenatal androgen with flutamide interferes with testicular development by inhibiting testicular descent, and also effects testicular morphology and function in both the descended and undescended testes of rats.
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- 2006
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27. Neonatal hepatitis in 2 siblings with Seckel syndrome.
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Deniz K, Kontaş O, and akçakuş M
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- Abnormalities, Multiple genetics, Family Health, Fatal Outcome, Female, Hepatitis genetics, Humans, Infant, Newborn, Intellectual Disability genetics, Intellectual Disability pathology, Liver pathology, Male, Microcephaly genetics, Nervous System Malformations genetics, Syndrome, Abnormalities, Multiple pathology, Hepatitis pathology, Microcephaly pathology, Nervous System Malformations pathology, Siblings
- Abstract
Seckel syndrome was described as the prototype of the primordial bird-head type of dwarfism. We report 2 cases of Seckel syndrome in siblings. Both cases showed peculiar phenotypic features. Autopsy was performed and microscopic examination of the livers displayed histologic features of neonatal hepatitis. In addition, our younger patient had central nervous system anomalies such as agenesis of corpus callosum, cerebral cyst, and primitive convolutional pattern. No previous reports of liver disease exist in patients with Seckel syndrome. The pathologic findings of such an unusual association and a review of literature are presented.
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- 2006
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28. Treatment of nevoid hyperkeratosis of the nipple and areola using a radiofrequency surgical unit.
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Ozyazgan I, Kontaş O, and Ferahbaş A
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- Adult, Female, Humans, Breast Diseases surgery, Keratosis surgery, Laser Therapy, Nipples
- Abstract
Background: Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare condition of unknown etiology. Verrucous thickening and pigmentation of the nipple and areola are the main features of the condition. Different therapeutic options, both medical and surgical, have been described., Objective: To use a radiofrequency surgical unit to treat an NHNA case, which was unresponsive to keratolytic therapy., Materials and Methods: The lesions of the nipple and areolas were excised tangentially with a diamond-shaped electrode of a radiofrequency surgical unit under local anesthesia., Results: The patient had a good cosmetic appearance after the treatment, and there was no recurrence at the ninth postoperative month., Conclusion: Radiofrequency for tangential excision in the treatment of NHNA lesions that have not responded to medical therapy can be an alternative surgical method.
- Published
- 2005
- Full Text
- View/download PDF
29. Use of high-dose intravenous corticosteroid treatment in a child with scleredema.
- Author
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Kurtoğlu S, Yüksel S, Gündüz Z, Per H, Narin N, Kontaş O, Ozdemir MA, and Caksen H
- Subjects
- Adolescent, Anti-Bacterial Agents therapeutic use, Dose-Response Relationship, Drug, Follow-Up Studies, Humans, Infusions, Intravenous, Male, Remission, Spontaneous, Scleredema Adultorum diagnosis, Scleredema Adultorum etiology, Tonsillitis complications, Tonsillitis drug therapy, Treatment Failure, Emergency Medical Services methods, Glucocorticoids administration & dosage, Methylprednisolone administration & dosage, Scleredema Adultorum drug therapy
- Published
- 2004
- Full Text
- View/download PDF
30. Previous injuries or scars as risk factors for the development of basal cell carcinoma.
- Author
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Ozyazgan I and Kontaş O
- Subjects
- Adult, Aged, Cell Transformation, Neoplastic, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Carcinoma, Basal Cell etiology, Cicatrix complications, Skin Neoplasms etiology, Wounds and Injuries complications
- Abstract
Basal cell carcinoma (BCC) is the most common malignant tumour in humans and most occur in elderly people. The pathogenesis of BCC is directly related to exposure to ultraviolet radiation in sunlight, but trauma is also mentioned occasionally. As well as one published series, several single cases have been reported. Our aim in the present study was to assess any possible relation between the development of BCC and trauma in a series of 92 patients, 12 of whom (13%) gave a history of previous injury. These lesions either developed directly after a sharp or blunt injury or in the scar tissue that had resulted from previous surgical incisions, burns, or dog bites. The male:female ratio was higher in the injured group (10:2) than in the uninjured group (44:36), but not significantly so (p = 0.11). Morphoea-like basal cell carcinomas were more common in the injured group (n = 91) (p = 0.06). We conclude that trauma might be considered as another aetiological agent for BCC.
- Published
- 2004
- Full Text
- View/download PDF
31. Effect of gestational nicotine treatment on newborn rat retina: a histopathological and morphometric analysis.
- Author
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Evereklioglu C, Ozkiriş A, Alaşehirli B, Sari I, Güldür E, Cengiz B, and Kontaş O
- Subjects
- Animals, Animals, Newborn, Body Weight physiology, Cell Count, Female, Male, Maternal-Fetal Exchange physiology, Nicotine administration & dosage, Pregnancy, Rats, Rats, Wistar, Retina pathology, Retinal Ganglion Cells pathology, Nicotine adverse effects, Retina drug effects
- Abstract
Background: Smoking is a significant risk factor in several debilitating and fatal diseases. It has been implicated in bilateral tobacco-toxic and Leber's hereditary optic neuropathies. Although it has been demonstrated that smoking has a cumulative effect on retinal and optic nerve functions and causes diffuse and localised retinal sensitivity decrease in healthy chronic heavy smokers, the affected retinal layer has not been identified and there is no experimental study investigating the effect of nicotine exposure during gestation on the newborn rat retina., Purpose: This experimental investigation evaluated histologically the influence in vivo of maternal nicotine treatment during pregnancy on the newborn rat retina. Different dosages of the test compound simulated the range of low, moderate, and heavy smokers in humans., Methods: Experimentally naive, adult female Wistar-albino rats weighing 200-250 g were mated with adult male rats over 2 days for copulation in the proportion of two females for every male animal. After confirming pregnancy with vaginal smear method, 40 gravid rats (dams) were then randomly assigned into four equal groups (three experimental and one control; n = 10 in each). On day 9 of gestation, groups 1, 2, and 3 experimental dams were treated with intraperitoneal (i.p.) (-)-nicotine tartrate at doses of 0.5, 1, and 2 mg kg body weight-1 day-1, respectively during pregnancy from gestational day 9-21. Group 4 control dams were given i.p. saline solution daily for the same period. After normal delivery, the newborn litters were sacrificed at postnatal day 1 or day 30. The eyes were enucleated for histopathologic and morphometric analysis of the retinas. Nicotine-induced neuronal changes were measured by morphometric analyses on cell counts of ganglion cell layer (linear cell density in number per unit length of retina) and thickness of the various retinal layers., Results: The litters in control group 4, and experimental groups 1 and 2 had normal retinal findings. On the other hand, morphometric analysis of retinal sections in experimental group 3 eyes demonstrated a 20.7% decrease in the number of surviving ganglion cells (40.7 +/- 2.0) compared with controls (51.3 +/- 1.1; p < 0.001). The thickness of whole retina (126.6 +/- 5.4 microm) was also reduced by 13.5% compared with controls (146.3 +/- 4.5 microm; p = 0.007). The main site of retinal atrophy was the inner plexiform layer (30.1 +/- 1.6 microm vs 43.5 +/- 1.3 microm; p < 0.001) with almost no change in the other retinal layers., Conclusions: Gestational nicotine treatment induces marked changes in the organisation of the developing retina in newborn rats histopathologically. Quantitative morphometric analysis clearly demonstrated that the two most affected structures were the retinal ganglion cells and the inner plexiform layer, both of which are supplied by central retinal artery.
- Published
- 2003
- Full Text
- View/download PDF
32. Serum inhibin B levels reflect contralateral testicular damage following unilateral testicular trauma.
- Author
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Ozkan KU, Kücükaydin M, Muhtaroğlu S, Kontaş O, and Karaca F
- Subjects
- Animals, Biomarkers, Inhibins blood, Male, Rats, Rats, Wistar, Spermatogenesis, Testicular Diseases etiology, Inhibins biosynthesis, Testicular Diseases metabolism, Testis injuries, Wounds and Injuries complications, Wounds and Injuries metabolism
- Abstract
Introduction: The aim of this study was to evaluate contralateral testicular damage (CTD) following unilateral blunt testicular trauma (BTT) and testicular capsule laceration (TCL) by the serum inhibin B level which is an accepted marker of spermatogenesis., Methods: Fifty peripubertal male Wistar albino rats were divided into 5 groups each containing 10 rats. Group 1 was the control group. Group 2 was the BTT group in which the right testicle was placed on a firm surface and a metal rod weighing 215 g was dropped onto the testicle from a height of 5.5 cm. Group 3 was the TCL group in which right testicular tunica albuginea was lacerated using the needle of 4/0 silk suture. Group 4 had right orchiectomy initially. Group 5 was the sham group. In all groups, 3-ml blood samples were taken and bilateral orchiectomies were performed 6 weeks after initial manipulations., Results: Groups 2 and 3 had decreased inhibin B levels (p < 0.001), although the orchiectomy group had normal levels. Histological analyses showed lower Johnsen scores for both trauma groups in the ipsilateral and contralateral testes (p < 0.05)., Conclusions: Serum inhibin B levels decrease following unilateral testicular trauma reflecting CTD., (Copyright 2003 S. Karger AG, Basel)
- Published
- 2003
- Full Text
- View/download PDF
33. Therapeutic effect of tirilazad mesylate (U-74006F), mannitol, and their combination on experimental ischemia.
- Author
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Oktem IS, Menkü A, Akdemir H, Kontaş O, Kurtsoy A, and Koç RK
- Subjects
- Animals, Brain Ischemia metabolism, Brain Ischemia pathology, Disease Models, Animal, Diuretics, Osmotic pharmacology, Drug Therapy, Combination, Mannitol pharmacology, Neuroprotective Agents pharmacology, Photomicrography, Pregnatrienes pharmacology, Rabbits, Random Allocation, Statistics, Nonparametric, Brain Ischemia drug therapy, Diuretics, Osmotic therapeutic use, Mannitol therapeutic use, Neuroprotective Agents therapeutic use, Pregnatrienes therapeutic use
- Abstract
The effect of tirilazad mesylate (U-74006F), mannitol, and their combination was investigated on focal cerebral ischemia induced by permanent middle cerebral artery (MCA) occlusion in rabbits. Rabbits were divided into four groups receiving vehicle, U-74006F, mannitol, and U-74006F plus mannitol. Hematocrit (hct), glucose, mean arterial blood pressure (MABP), pH, PCO2, and PO2 were measured both before and after occlusion. Seventy-two hours following the permanent MCA occlusion, the neurological outcome was assessed and a quantitative neuropathologic examination was performed in all rabbits. The neurological outcome was better in the rabbits treated with U-74006F plus mannitol than in the other groups. The size of infarction of the affected hemisphere following MCA occlusion was 49.7% in the control group, 30.6% in the U-74006F group, 47.6% in the mannitol group, and 24.1% in the U-74006F plus mannitol group. There was a statistically significant reduction in infarct size in the U-74006F plus mannitol group compared with the other groups (P < 0.05). The ratio of ischemic neurons to total neurons in the cortex was smaller in the U-74006F plus mannitol group than in the other groups. The ratio of ischemic neurons to total neurons in the subcortex was significantly lower in the U-74006F plus mannitol group than in the other groups (P < 0.05). Our data provide evidence for the beneficial effects of both U-74006F and U-74006F plus mannitol in promoting neurological recovery and preservation of the ischemic area.
- Published
- 2000
- Full Text
- View/download PDF
34. Detection of intestinal bacterial translocation in subclinical ischemia-reperfusion using the polymerase chain reaction technique.
- Author
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Küçükaydin M, Kocaoğlu C, Köksal F, and Kontaş O
- Subjects
- Animals, Bacteremia, DNA, Bacterial analysis, Escherichia coli physiology, Intestines microbiology, Lymph Nodes microbiology, Male, Polymerase Chain Reaction, Rats, Rats, Sprague-Dawley, Bacterial Translocation, Intestines blood supply, Reperfusion Injury microbiology
- Abstract
Background/purpose: The purpose of this study was to evaluate the detection of bacterial translocation after subclinical ischemia reperfusion injuries in rats with the polymerase chain reaction (PCR) technique., Methods: Six-week-old weaning rats were divided into 3 groups. (1) Experiment rats (n = 20) were gavaged with 10(10) Escherichia coli followed by superior mesentery artery occluded for 10 minutes, then reperfused for 30 minutes. (2) Control rats (n = 20) received bacterial gavage. (3) Group 3 were sham rats (n = 20). After the procedure, 3 mL of blood was obtained from the portal vein. The terminal ileum and mesenteric lymph node (MLN) near the terminal ileum were removed. E. coli DNA was detected in blood and MLN samples by PCR, and histological changes were examined., Results: E. coli DNA detection in ischemia-reperfusion (I/R) group animals was 6 of 20 (30%) in the MLN and 2 of 20 (10%) in the blood. PCR was negative in all the rats in the control group and in the sham group (P < .05). There were no significant differences in the histological examination of rat intestines., Conclusion: These data suggest that subclinical intestinal I/R injury results in bacterial translocation. Also, PCR is a highly sensitive and rapid method to detect the presence of microbial DNA.
- Published
- 2000
- Full Text
- View/download PDF
35. Burn scar sarcoma.
- Author
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Ozyazgan I and Kontaş O
- Subjects
- Adult, Female, Fibrosarcoma pathology, Humans, Skin Neoplasms pathology, Burns complications, Fibrosarcoma etiology, Neoplasms, Post-Traumatic, Scalp injuries, Skin Neoplasms etiology
- Abstract
Malignancies developing in burn scars have been known for a long time and are generally epidermoid carcinomas although a few sarcoma cases have been reported. A case of fibrosarcoma developing in the burn scar was presented in this report and the literature reviewed.
- Published
- 1999
- Full Text
- View/download PDF
36. A new subtype of meningioma.
- Author
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Akdemir H, Kontaş O, Oktem IS, Tucer B, Kafadar H, and Paşaoğlu A
- Subjects
- Adult, Blood Vessels pathology, Brain Edema etiology, Female, Humans, Male, Meningeal Neoplasms complications, Meningeal Neoplasms diagnostic imaging, Meningeal Neoplasms pathology, Meningeal Neoplasms surgery, Meningioma complications, Meningioma diagnostic imaging, Meningioma pathology, Meningioma surgery, Middle Aged, Pericytes pathology, Tomography, X-Ray Computed, Treatment Outcome, Meningeal Neoplasms classification, Meningioma classification
- Abstract
Three patients with small meningiomas presented with diffuse cerebral edema that was out of proportion to the size of tumors. All lesions were small and no brain invasion or unusual tumor vascularity or dural sinus involvement was noted in any of the three cases. Tumor material was subjected to conventional and immunohistochemical stains. All three tumors showed benign meningothelial components, prominent formation of hyaline inclusions (pseudopsammoma bodies), and striking vascular mural proliferation of small dark cells. All patients have remained asymptomatic without any evidence of tumor recurrence after a follow-up of 4-6 years. These tumors showed proliferation of pericytes in blood vessel walls and, therefore, represent a new subtype of meningothelial meningioma. In the study presented here, the location, size, histotype, and clinical findings that may influence the development of peritumoral brain edema are discussed in detail.
- Published
- 1999
- Full Text
- View/download PDF
37. A model of hypoxia-induced necrotizing enterocolitis: the role of distension.
- Author
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Kazez A, Küçükaydin N, Küçükaydin M, Kontaş O, Okur H, and Doğan P
- Subjects
- 3,4-Methylenedioxyamphetamine analysis, Animals, Free Radicals, Intestines blood supply, Intestines chemistry, Lipid Peroxidation, Rats, Rats, Wistar, Reperfusion Injury pathology, Enterocolitis, Pseudomembranous etiology, Enterocolitis, Pseudomembranous pathology, Hypoxia complications, Intestines pathology
- Abstract
Background/purpose: This study was performed to investigate additional effects of intestinal distension in the damage to the gut caused by hypoxia-reperfusion., Methods: Five groups each consisting of ten 1-day-old Wistar albino rat pups were studied; Group 1, hypoxia-reoxygenation; Group 2, hypoxia-reoxygenation and distension; Group 3, distension and hypoxia-reoxygenation; Group 4, distension; and Group 5, control. Hypoxia was induced by placing the rat pups in a 100% carbon dioxide chamber for 5 minutes. After the hypoxia, the pups were exposed to 100% oxygen for reoxygenation for 5 minutes. The intestinal distension was carried out with a fine 21-gauge SILASTIC cannula via rectal route. The rats were killed on the third day, and all the intestine were harvested from duodenum to sigmoid colon. Malondialdehyde (MDA) levels were determined as an index of lipid peroxidation related to free radical reaction in the intestine. The histopathologic investigation was carried out by light microscopy in a blinded fashion., Results: The MDA levels of Group 3 animals were significantly higher than those in Group 1, 4, and the control group (P < .05). The MDA level of Group 2 did not differ significantly from that of the Group 3 (P > .05). All MDA levels of the study groups also were significantly higher than the control group (P < .05)., Conclusion: The results demonstrated that intestinal distension increased the damaging effects of hypoxia-reoxygenation in the gut.
- Published
- 1997
- Full Text
- View/download PDF
38. Effects of angiotensin converting enzyme inhibitor cilazapril and angiotensin II antagonist saralasin in ovarian hyperstimulation syndrome in the rabbit.
- Author
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Sahin Y, Kontaş O, Müderris II, and Cankurtaran M
- Subjects
- Animals, Ascitic Fluid, Body Weight, Chorionic Gonadotropin administration & dosage, Cilazapril administration & dosage, Estradiol blood, Female, Menotropins, Ovarian Hyperstimulation Syndrome chemically induced, Ovulation drug effects, Progesterone blood, Rabbits, Saralasin administration & dosage, Angiotensin II antagonists & inhibitors, Angiotensin-Converting Enzyme Inhibitors pharmacology, Cilazapril pharmacology, Ovarian Hyperstimulation Syndrome metabolism, Saralasin pharmacology
- Abstract
We investigated the possible effects of the angiotensin converting enzyme (ACE) inhibitor cilazapril and angiotensin II antagonist saralasin on ovulation, ovarian steroidogenesis and ascites formation in the ovarian hyperstimulation syndrome (OHSS) in the rabbit model. OHSS was induced in rabbits by human menopausal gonadotropin (hMG) and intermittent human chorionic gonadotropin (hCG). In the cilazapril group (n = 10), animals also received cilazapril 2 mg/kg intraperitoneally daily for 7 days. In the saralasin group (n = 8), animals received saralasin intraperitoneally 1 h before or 1 h after hCG administration. Control animals (n = 8), received intraperitoneal saline solution. Serial blood samples were drawn on days 1, 5, 7 and 9 to measure serum estradiol and progesterone levels. On day 9, all rabbits underwent surgical exploration. Peritoneal and pleural fluid formation, ovarian weights and number of ovulations were determined. The volume of the ascitic and pleural fluids after hyperstimulation were not statistically different between the control, cilazapril and saralasin groups. The weight gains and ovarian weights of animals were similar between treatment and control groups. Saralasin significantly (p < 0.05) inhibited ovulation, but cilazapril did not. Cilazapril and saralasin did not affect progesterone production. Only cilazapril significantly decreased estradiol production (p < 0.05). In conclusion, the ACE inhibitor cilazapril and angiotensin II antagonist saralasin did not prevent ascites formation in OHSS. The ovarian renin-angiotensin system may not be the only factor acting in ascites formation in the OHSS.
- Published
- 1997
- Full Text
- View/download PDF
39. Scintigraphic visualization of ocular melanoma with Tc-99m glutathione.
- Author
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Tutuş A, Erkiliç K, Ercan MT, Kontaş O, Aydin M, and Doğan H
- Subjects
- Eye Neoplasms pathology, Humans, Male, Melanoma pathology, Middle Aged, Technetium Tc 99m Sestamibi, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed, Eye Neoplasms diagnostic imaging, Glutathione analogs & derivatives, Melanoma diagnostic imaging, Technetium
- Abstract
In a patient with ocular melanoma scintigraphy obtained with 99mTc-GSH clearly demonstrated the histologically proven ocular lesion both in planar and SPECT images. 99mTc-sestamibi study obtained in the same patient three days later was negative. 99mTc-GSH is a potential alternative to the currently used radiopharmaceuticals for imaging both cutaneous and ocular melanomas and their metastases.
- Published
- 1997
- Full Text
- View/download PDF
40. Protective effect of magnesium supplementation on experimental 3-methyl cholanthrene-induced fibrosarcoma and changes in tissue magnesium distribution during carcinogenesis in rats.
- Author
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Patiroğlu T, Sahin G, Kontaş O, Uzüm K, and Saraymen R
- Subjects
- Animals, Anticarcinogenic Agents chemistry, Anticarcinogenic Agents pharmacokinetics, Anticarcinogenic Agents therapeutic use, Fibrosarcoma metabolism, Food, Fortified, Magnesium chemistry, Rats, Rats, Inbred Strains, Tissue Distribution drug effects, Fibrosarcoma chemically induced, Fibrosarcoma diet therapy, Magnesium pharmacokinetics, Magnesium pharmacology, Methylcholanthrene
- Abstract
In this study, we wanted to examine the effect of magnesium (Mg2+) supplementation on the experimental 3-methyl cholanthrene (3-MC)-induced fibrosarcoma and alterations in (Mg2+) distribution in several tissues of the rats, during carcinogenesis. It was determined that serum and tissue (Mg2+) levels of the rats in (Mg2+)-supplemented diet group were higher than those of the rats in the (Mg2+)-nonsupplemented and control groups. The mean time of fibrosarcoma development for (Mg2+)-supplemented group was longer than (Mg2+)-nonsupplemented group (p < 0.05). Symptoms of hypermagnesemia were not observed in any of the rats. These results suggests that dietary (Mg2+) supplementation may have a partial anti-carcinogenic effect on experimental 3-MC-induced fibrosarcoma by prolongation of the latent period of carcinogenesis.
- Published
- 1997
- Full Text
- View/download PDF
41. Cranioplasty with bone flaps preserved under the scalp.
- Author
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Paşaoğlu A, Kurtsoy A, Koc RK, Kontaş O, Akdemir H, Oktem IS, Selçuklu A, and Kavuncu IA
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Male, Middle Aged, Suture Techniques, Bone Transplantation methods, Brain Diseases surgery, Brain Edema surgery, Brain Injuries surgery, Craniotomy methods, Tissue Preservation
- Abstract
Cranial bone defects in 27 patients were repaired with bone flaps preserved under the scalp. Head trauma (thirteen patients), cerebrovascular disorder (five patients), postoperative brain swelling (seven patients), and cerebral infective disease (two patients) accounted for the cranial defects. The bone flaps are reimplanted after 14-98 days. The follow-up period was 6 to 26 months. We have encountered no complications related to this technique in 27 consecutive cases.
- Published
- 1996
- Full Text
- View/download PDF
42. Fibrin glue and conventional sutured vasal anastomosis in the rat.
- Author
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Küçükaydin M, Okur H, Kontaş O, and Patiroğlu TE
- Subjects
- Animals, Evaluation Studies as Topic, Female, Male, Microsurgery, Rats, Rats, Sprague-Dawley, Testis pathology, Anastomosis, Surgical, Fibrin Tissue Adhesive therapeutic use, Sutures, Vasovasostomy methods
- Abstract
The present study was undertaken to evaluate the use of fibrin glue (Tisseel, Immune U.S., Inc) for vasovasostomy and to compare this technique to conventional sutured vasovasostomy. Thirty immature Sprague-Dawley rats, weighing from 60 to 80 g, were used in this study. A conventional one-layer sutured anastomosis (Ethilon 10-O) in 10 rats was compared to a fibrin glue technique of vasal anastomosis (10 rats). The fibrin glue technique was performed without sutures and was unstented. The biological glue was utilized to seal both ends of the vas. The contralateral vas was ligated with 5-O prolein. In the control group (10 rats) the left vas was ligated in the same way, and only the contralateral vas was explored. After 2 months, one male and two female rats were placed in a cage for a further 2 months. At the end of this period, the fertility rate was 80% (n = 8) of the control group, 60% (n = 6) of the conventional anastomosis, and 70% (n = 7) of fibrin glue groups, respectively. The testes and vasal specimens were evaluated for the presence of sperm granuloma, and histologic studies were performed. The incidence of sperm granuloma after vasovasostomy was 20% (n = 2) for the fibrin glue group and 30% (n = 3) for the sutured group. The sperms were seen in the proximal and distal side of the vasal anastomosis in 10 rats in the control group, in 8 in the glue group, and in 8 in the conventional sutured anastomosis group.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1995
- Full Text
- View/download PDF
43. Hypoxia-induced necrotizing enterocolitis in the immature rat: the role of lipid peroxidation and management by vitamin E.
- Author
-
Okur H, Küçükaydin M, Köse K, Kontaş O, Doğam P, and Kazez A
- Subjects
- Animals, Animals, Newborn, Disease Models, Animal, Enterocolitis, Pseudomembranous etiology, Free Radicals, Malondialdehyde metabolism, Rats, Rats, Wistar, Enterocolitis, Pseudomembranous drug therapy, Enterocolitis, Pseudomembranous metabolism, Hypoxia complications, Lipid Peroxidation, Vitamin E therapeutic use
- Abstract
The authors developed an experimental model of necrotizing enterocolitis (NEC) by hypoxia-reoxygenation, and determined the content of malondialdehyde levels as an index of lipid peroxidation, related with a free-radical reaction in the gastrointestinal tract of newborn rats. They also investigated the role of vitamin E, an antioxidant, in this free-radical injury. The study was performed on 1-day-old rats. The 30 rat pups were divided into three groups. Hypoxia was induced by placing the pups in a 100% carbon dioxide chamber for 5 minutes. The pups were reoxygenated with 100% oxygen for 5 minutes. Group 1 (n = 10) was subjected to hypoxia-reoxygenation and killed 3 days after hypoxia. Group 2 (n = 10) was subjected to hypoxia-reoxygenation and treated with vitamin E (30 IU/kg/d intraperitoneally) for the next 3 days, and killed. Group 3 (n = 10) rats served as controls. The histopathology of the intestinal lesions in group 1 animals was characteristic of ischemic injury and ranged from superficial epithelial damage with villous shortening to transmural necrosis. In the vitamin E-treated animals these lesions were milder. The malondialdehyde levels of group 1 were significantly higher than those of the other two groups (P < .001). This study shows that oxidant-mediated lipid peroxidation injury plays a central role in mediating hypoxia-induced intestinal necrosis and suggests that vitamin E may play a therapeutic role in NEC.
- Published
- 1995
- Full Text
- View/download PDF
44. Ectopic adrenal tissue in the inguinal region in children.
- Author
-
Okur H, Küçükaydin M, Kazez A, and Kontaş O
- Subjects
- Adolescent, Child, Child, Preschool, Hernia, Inguinal pathology, Hernia, Inguinal surgery, Humans, Infant, Infant, Newborn, Adrenal Glands, Choristoma pathology, Inguinal Canal pathology
- Abstract
Adrenal rests are common in children and are most often found as bright yellow, retroperitoneal nodules from the diaphragm to the pelvis. They are usually incidental findings during surgery. In a 12-month period, 268 children, 18 days to 15 years (mean 3.2 years) of age, underwent 304 operations for common inguinoscrotal disorders at the Department of Pediatric Surgery, Erciyes University Medical School. There were 252 males and 16 females, (M/F 15.7:1). Ectopic adrenal tissue was found in nine males (3%). This report concerns the incidence and structure of aberrant adrenal tissue found in children during inguinoscrotal operations, including its embryology, histology, and clinical implications.
- Published
- 1995
- Full Text
- View/download PDF
45. Sarcomatoid squamous cell carcinoma of the right renal pelvis with liver metastasis: case report.
- Author
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Kandemir O, Tatlişen A, Kontaş O, Orskiran G, and Kahya HA
- Subjects
- Adult, Carcinoma, Squamous Cell complications, Humans, Kidney Calculi complications, Kidney Neoplasms complications, Liver Neoplasms complications, Male, Carcinoma, Squamous Cell secondary, Kidney Neoplasms pathology, Kidney Pelvis, Liver Neoplasms secondary
- Abstract
We report on a man with sarcomatoid squamous cell carcinoma of the right kidney with liver metastases. Bilateral renal lithiasis and well differentiated squamous cell carcinomas of the right renal pelvis were also noted. This uncommon case is discussed and the literature is reviewed.
- Published
- 1995
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