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2 results on '"Koloskova EE"'

1. [The anti-inflammatory activity of structural analogs of the platelet-activating factor].

Author

Melikiants AG, Kulikov VI, Koloskova EE, Kuznetsova TI, Dergousov AA, and Lipatkina LIu

Subjects
Animals, Anti-Inflammatory Agents therapeutic use, Aspirin therapeutic use, Carrageenan, Dexamethasone therapeutic use, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Indomethacin therapeutic use, Inflammation chemically induced, Inflammation drug therapy, Male, Rats, Rats, Inbred Strains, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Platelet Activating Factor analogs & derivatives, Platelet Activating Factor therapeutic use
Abstract

The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.

Published
1991

2. [Study of rat liver mitochondrial proteins by two-dimensional electrophoresis].

Author

Volodina TV, Koloskova EE, Shishkin SS, and Kozel'tsev VL

Subjects
Animals, Electrophoresis, Polyacrylamide Gel methods, Female, Molecular Weight, Rats, Mitochondria, Liver analysis, Proteins analysis
Abstract

About 50 protein fractions with molecular mass 15-158 kDa were detected in purified mitochondria isolated from rat liver homogenate after two-dimensional electrophoresis performed as described by O'Farrell. Individual spots, corresponding to proteins of inner mitochondrial membrane, disappeared from electrophoregrams as a result of incubation of the isolated mitochondria at 37 degrees and pH 7.5. Degradation of these proteins was augmented if ATP was added into incubation mixtures. Intrinsic proteolytic activity occurred in rat liver mitochondria as shown by these and previously obtained data.

Published
1987

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