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[The anti-inflammatory activity of structural analogs of the platelet-activating factor].
- Source :
-
Farmakologiia i toksikologiia [Farmakol Toksikol] 1991 Jul-Aug; Vol. 54 (4), pp. 43-5. - Publication Year :
- 1991
-
Abstract
- The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.
- Subjects :
- Animals
Anti-Inflammatory Agents therapeutic use
Aspirin therapeutic use
Carrageenan
Dexamethasone therapeutic use
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Indomethacin therapeutic use
Inflammation chemically induced
Inflammation drug therapy
Male
Rats
Rats, Inbred Strains
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Platelet Activating Factor analogs & derivatives
Platelet Activating Factor therapeutic use
Subjects
Details
- Language :
- Russian
- ISSN :
- 0014-8318
- Volume :
- 54
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Farmakologiia i toksikologiia
- Publication Type :
- Academic Journal
- Accession number :
- 1786825