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1. Depressive Symptoms and Plasma Markers of Alzheimer's Disease and Neurodegeneration: A Coordinated Meta-Analysis of 8 Cohort Studies

Author

Twait, Emma L., Kamarioti, Maria, Verberk, Inge M.W., Teunissen, Charlotte E., Nooyens, Astrid C.J., Monique Verschuren, W.M., Visser, Pieter Jelle, Huisman, Martijn, Kok, Almar A.L., Eline Slagboom, P., Beekman, Marian, Vojinovic, Dina, Lakenberg, Nico, Arfan Ikram, M., Schuurmans, Isabel K., Wolters, Frank J., Moonen, Justine E.F., Gerritsen, Lotte, van der Flier, Wiesje M., and Geerlings, Mirjam I.

Published
2024
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11. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Published
2024

12. Genomics Research of Lifetime Depression in the Netherlands : The BIObanks Netherlands Internet Collaboration (BIONIC) Project

Author

Huider, Floris, Milaneschi, Yuri, Hottenga, Jouke Jan, Bot, Mariska, Rietman, Liset, Kok, Almar A.L., Galesloot, Tessel E., T' Hart, Leen M., Rutters, Femke, Blom, Marieke T., Rhebergen, Didi, Visser, Marjolein, Brouwer, Ingeborg, Feskens, Edith, Hartman, Catharina A., Oldehinkel, Albertine J., De Geus, Eco J.C., Kiemeney, Lambertus A., Huisman, Martijn, Picavet, Susan J., Verschuren, Monique, Van Loo, Hanna M., Penninx, Brenda W.J.H., Boomsma, Dorret I., Huider, Floris, Milaneschi, Yuri, Hottenga, Jouke Jan, Bot, Mariska, Rietman, Liset, Kok, Almar A.L., Galesloot, Tessel E., T' Hart, Leen M., Rutters, Femke, Blom, Marieke T., Rhebergen, Didi, Visser, Marjolein, Brouwer, Ingeborg, Feskens, Edith, Hartman, Catharina A., Oldehinkel, Albertine J., De Geus, Eco J.C., Kiemeney, Lambertus A., Huisman, Martijn, Picavet, Susan J., Verschuren, Monique, Van Loo, Hanna M., Penninx, Brenda W.J.H., and Boomsma, Dorret I.

Abstract

In this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands Internet Collaboration (BIONIC). Across the Netherlands we collected data on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) lifetime MDD diagnosis in 132,850 Dutch individuals. Currently, N = 66,684 of these also have genomewide single nucleotide polymorphism (SNP) data. We initiated this project because the complex genetic basis of MDD requires large population-wide studies with uniform in-depth phenotyping. For standardized phenotyping we developed the LIDAS (LIfetime Depression Assessment Survey), which then was used to measure MDD in 11 Dutch cohorts. Data from these cohorts were combined with diagnostic interview depression data from 5 clinical cohorts to create a dataset of N = 29,650 lifetime MDD cases (22%) meeting DSM-5 criteria and 94,300 screened controls. In addition, genomewide genotype data from the cohorts were assembled into a genomewide association study (GWAS) dataset of N = 66,684 Dutch individuals (25.3% cases). Phenotype data include DSM-5-based MDD diagnoses, sociodemographic variables, information on lifestyle and BMI, characteristics of depressive symptoms and episodes, and psychiatric diagnosis and treatment history. We describe the establishment and harmonization of the BIONIC phenotype and GWAS datasets and provide an overview of the available information and sample characteristics. Our next step is the GWAS of lifetime MDD in the Netherlands, with future plans including fine-grained genetic analyses of depression characteristics, international collaborations and multi-omics studies.

Published
2024

13. Psychosocial factors, health behaviors and risk of cancer incidence:Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

14. Modifiable Risk Factors for Accelerated Decline in Processing Speed: Results from Three Dutch Population Cohorts

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Jaarsma, E., Nooyens, A., Kok, Almar A.L., Köhler, S., van Boxtel, M., Verschuren, W. M.M., Huisman, M., Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Jaarsma, E., Nooyens, A., Kok, Almar A.L., Köhler, S., van Boxtel, M., Verschuren, W. M.M., and Huisman, M.

Published
2024

17. Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project

Author

Huider, Floris, primary, Milaneschi, Yuri, additional, Hottenga, Jouke-Jan, additional, Bot, Mariska, additional, Rietman, M. Liset, additional, Kok, Almar A.L., additional, Galesloot, Tessel E., additional, ‘t Hart, Leen M., additional, Rutters, Femke, additional, Blom, Marieke T., additional, Rhebergen, Didi, additional, Visser, Marjolein, additional, Brouwer, Ingeborg, additional, Feskens, Edith, additional, Hartman, Catharina A., additional, Oldehinkel, Albertine J., additional, de Geus, Eco J.C., additional, Kiemeney, Lambertus A., additional, Huisman, Martijn, additional, Picavet, H. Susan J., additional, Verschuren, W.M. Monique, additional, van Loo, Hanna M., additional, Penninx, Brenda W.J.H., additional, and Boomsma, Dorret I., additional

Published
2024
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18. Corrigendum to “Bipolarity in Older individuals Living without rugs (BOLD): Protocol and preliminary findings” [J. Affec. Disord. 348 (2024) 160–166]

Author

Beunders, Alexandra J.M., primary, Regeer, Eline, additional, van Eijkelen, Marieke, additional, Mathijssen, Henk, additional, Nijboer, Chris, additional, Schouws, Sigfried N.T.M., additional, van Oppen, Patricia, additional, Kok, Almar A.L., additional, Kupka, Ralph W., additional, and Dols, Annemiek, additional

Published
2024
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20. Alzheimer’s disease plasma markers and depressive symptoms: an IPD meta‐analysis

Author

Twait, Emma L., primary, Kamarioti, Maria, additional, Verberk, Inge M.W., additional, Teunissen, Charlotte E., additional, Nooyens, Astrid C.J., additional, Verschuren, Monique WM, additional, Visser, Pieter Jelle, additional, Huisman, Martijn, additional, Kok, Almar A.L., additional, Slagboom, P. Eline, additional, Beekman, Marian, additional, Ikram, M. Arfan, additional, Schuurmans, Isabel K, additional, Wolters, Frank J., additional, Moonen, Justine E., additional, Gerritsen, Lotte, additional, van der Flier, Wiesje M., additional, and Geerlings, Mirjam I., additional

Published
2023
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23. Depression, anxiety, and the risk of cancer:An individual participant data meta-analysis

Author

van Tuijl, Lonneke A., Basten, Maartje, Pan, Kuan Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I., Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R., Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Rosmalen, Judith G.M., Ranchor, Adelita V., van Tuijl, Lonneke A., Basten, Maartje, Pan, Kuan Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I., Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R., Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Rosmalen, Judith G.M., and Ranchor, Adelita V.

Abstract

Background: Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium. Methods: The PSY-CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person-years of follow-up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two-stage IPD meta-analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random-effects meta-analyses (stage 2). Results: No associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol-related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking-related cancers (hazard ratios [HRs], 1.06–1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04–1.23). Conclusions: Depression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking-related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking-related cancers. Preregistration number: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.

Published
2023

24. Differences in the Mediating Role of HL in Socioeconomic Inequalities in Health Across Age Groups: Results from the Dutch Doetinchem Cohort Study

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Klokgieters, Silvia S., Picavet, H. Susan J., Huisman, Martijn, Monique Verschuren, W. M., Uiters, Ellen A.H., Kok, Almar A.L., Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Klokgieters, Silvia S., Picavet, H. Susan J., Huisman, Martijn, Monique Verschuren, W. M., Uiters, Ellen A.H., and Kok, Almar A.L.

Published
2023

25. Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) project

Author

Precision Psychiatry, Acuut & Intensieve Zorg Med., Beunders, Alexandra J.M., Klaus, Federica, Kok, Almar A.L., Schouws, Sigfried N.T.M., Kupka, Ralph W., Blumberg, Hilary P., Briggs, Farren, Eyler, Lisa T., Forester, Brent P., Forlenza, Orestes V., Gildengers, Ariel, Jimenez, Esther, Mulsant, Benoit H., Patrick, Regan E., Rej, Soham, Sajatovic, Martha, Sarna, Kaylee, Sutherland, Ashley, Yala, Joy, Vieta, Eduard, Villa, Luca M., Korten, Nicole C.M., Dols, Annemieke, Precision Psychiatry, Acuut & Intensieve Zorg Med., Beunders, Alexandra J.M., Klaus, Federica, Kok, Almar A.L., Schouws, Sigfried N.T.M., Kupka, Ralph W., Blumberg, Hilary P., Briggs, Farren, Eyler, Lisa T., Forester, Brent P., Forlenza, Orestes V., Gildengers, Ariel, Jimenez, Esther, Mulsant, Benoit H., Patrick, Regan E., Rej, Soham, Sajatovic, Martha, Sarna, Kaylee, Sutherland, Ashley, Yala, Joy, Vieta, Eduard, Villa, Luca M., Korten, Nicole C.M., and Dols, Annemieke

Published
2023

27. Sex Differences in Cognitive Functioning with Aging in the Netherlands

Author

Public Health Practice, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Nooyens, Astrid C.J., Wijnhoven, Hanneke A.H., Schaap, Laura S., Sialino, Lena D., Kok, Almar A.L., Visser, Marjolein, Verschuren, W. M.Monique, Picavet, H. Susan J., Van Oostrom, Sandra H., Public Health Practice, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Nooyens, Astrid C.J., Wijnhoven, Hanneke A.H., Schaap, Laura S., Sialino, Lena D., Kok, Almar A.L., Visser, Marjolein, Verschuren, W. M.Monique, Picavet, H. Susan J., and Van Oostrom, Sandra H.

Published
2022

28. Mental health and perceived impact during the first Covid-19 pandemic year: A longitudinal study in Dutch case-control cohorts of persons with and without depressive, anxiety, and obsessive-compulsive disorders

Author

Kok, Almar A.L., primary, Pan, Kuan-Yu, additional, Rius-Ottenheim, Nathaly, additional, Jörg, Frederike, additional, Eikelenboom, Merijn, additional, Horsfall, Melany, additional, Luteijn, Rob, additional, van Oppen, Patricia, additional, Rhebergen, Didi, additional, Schoevers, Robert A., additional, Giltay, Erik J., additional, and Penninx, Brenda W.J.H., additional

Published
2022
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29. The Longitudinal Aging Study Amsterdam COVID-19 exposure index: a cross-sectional analysis of the impact of the pandemic on daily functioning of older adults

Author

Hoogendijk, Emiel O., primary, Schuster, Noah A., additional, van Tilburg, Theo G., additional, Schaap, Laura A., additional, Suanet, Bianca, additional, de Breij, Sascha, additional, Kok, Almar A.L., additional, van Schoor, Natasja M., additional, Timmermans, Erik J., additional, de Jongh, Renate T., additional, Visser, Marjolein, additional, and Huisman, Martijn, additional

Published
2022
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31. Differences in the Mediating Role of HL in Socioeconomic Inequalities in Health Across Age Groups: Results from the Dutch Doetinchem Cohort Study.

Author

Klokgieters, Silvia S., Picavet, H. Susan J., Huisman, Martijn, Monique Verschuren, W. M., Uiters, Ellen A. H., and Kok, Almar A.L.

Subjects
SOCIOECONOMIC disparities in health, HEALTH literacy, OLDER people, ADULT education, DISEASE incidence, AGE groups
Abstract

Background: Although it is known that health literacy (HL) plays an explanatory role in educational inequalities in health, it is unknown whether this role varies across age groups. Objective: The purpose of this study was to investigate whether the mediating role of HL in educational inequalities in four health outcomes varies across age groups: age 46 to 58 years, age 59 to 71 years, and age 72 to 84 years. Methods: We used data from the Dutch Doetinchem Cohort Study, which included 3,448 participants. We included years of education as predictor, chronic illness prevalence and incidence, mental and self-perceived health as outcomes, and HL, based on self-report, as mediator. We used multiple-group mediation models to compare indirect effects across age groups. Key Results: In the complete sample without age stratification, HL partly mediated the effect of education on all health outcomes except for incidence of chronic diseases. These indirect effect estimates were larger for subjective (self-perceived health, proportion mediated [PM] = 37%, and mental health, PM = 37%) than for objective health outcomes (prevalence of chronic disease, PM = 17%). For the prevalence of chronic disease, the indirect effect estimate was significantly larger among individuals age 46 to 58 years compared to individuals age 59 to 71 years and for incidence of chronic disease also compared to individuals age 72 to 84 years. All other indirect effect estimates did not differ significantly between age groups. Using an alternative cut-off point for HL or adjusting for cognitive functioning did not meaningfully change the results. Conclusions: Overall, we found that the explanatory role of HL in educational inequalities in mental and subjective health was stable but that it varied across age groups for chronic diseases, where it was largest among individuals age 46 to 58 years. Future studies may investigate the benefits of starting to intervene on HL from a younger age but means to improve HL may also benefit the subjective health of older adults with lower education. [HLRP: HL Research and Practice. 2023;7(1):e26–e38.] Plain Language Summary: This study examined age-group differences in the mediating role of HL in the relationship between education and health. Overall, we found that the explanatory role of HL in educational inequalities in mental and subjective health was stable but that it varied across age groups for chronic diseases, where it was largest among individuals age 46 to 58 years compared to individuals age 59 to 71 years and individuals age 72 to 84 years. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Psychosocial factors and cancer incidence (PSY-CA):Protocol for individual participant data meta-analyses

Author

van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Abstract

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Published
2021

33. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

MS Medische Oncologie, Cancer, Cardiovasculaire Epi Team 7a, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 5, Public Health Practice, Interne Geneeskunde Vasculaire, AIOS Psychiatrie, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, MS Medische Oncologie, Cancer, Cardiovasculaire Epi Team 7a, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 5, Public Health Practice, Interne Geneeskunde Vasculaire, AIOS Psychiatrie, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

36. Factors across life associated with remaining free from functional limitations despite lifelong exposure to socioeconomic adversity

Author

Kok, Almar A.L., Stafford, Mai, Cosco, Theodore D., Huisman, Martijn, Deeg, Dorly, Kuh, Diana, Cooper, Rachel, Kok, Almar A.L., Stafford, Mai, Cosco, Theodore D., Huisman, Martijn, Deeg, Dorly, Kuh, Diana, and Cooper, Rachel

Abstract

Background: There are substantial socioeconomic inequalities in functional limitations in old age. Resilience may offer new insights into these inequalities by identifying constellations of factors that protect some individuals from developing functional limitations despite socioeconomic adversity. Methods: Data from 1973 participants in the Medical Research Council National Survey of Health and Development (Great Britain), followed from birth until age 60-64, were used. Functional limitations were defined as reporting difficulty with at least 1 of 16 activities at age 60-64. Lifetime socioeconomic adversity was based on socioeconomic trajectories, categorised into three adversity levels. Analysis of covariance and regression models were used to compare psychosocial factors and health-related behaviours between a Resilient' group (high adversity but no functional limitations) and five groups with other combinations of adversity and limitations. Results: Prevalence of functional limitations in high, intermediate and low adversity groups was 44%, 30% and 23% in men, and 61%, 55% and 49% in women, respectively. Compared with the other high adversity group, the resilient group had a lower prevalence of childhood illness (12% vs 19%) and obesity throughout ages 43-64 (70% vs 55%). Partially adjusted models also showed higher adolescent self-management, lower neuroticism, higher prevalence of volunteer work and physical activity (age 60-64) and lower prevalence of smoking (age 43) in the resilient. Marital status and contact frequency were not associated with resilience. Conclusion: Results suggest protection against childhood illness, health-behavioural factors and self-regulation as targets for interventions across life that may particularly benefit those with long-term exposure to socioeconomic adversity.

Published
2019
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37. Smoking cessation and 16-year trajectories of functional limitations among Dutch older adults: Results from the Longitudinal Aging Study Amsterdam

Author

Timmermans, Erik J., Huisman, Martijn, Kok, Almar A.L., Kunst, Anton E., Timmermans, Erik J., Huisman, Martijn, Kok, Almar A.L., and Kunst, Anton E.

Abstract

Background: This study examined whether smoking cessation in middle age and old age is associated with following a successful trajectory of functional limitations over time in Dutch older adults. Methods: We used 16-year longitudinal data from 645 participants of the Longitudinal Aging Study Amsterdam. Three types of trajectories regarding functional limitations over time were defined: successful (high initial level of functioning and limited decline), late decline (high initial level of functioning and late onset of decline), and early decline (lower initial level of functioning and early onset of decline). Smoking cessation status was self-reported and categorized into: early quitters (stopped in middle age [35-40 years]), late quitters (already smoked in middle age and stopped in old age [≥55 years]), and continued smokers (smoked in middle age and still smoking in old age). Multinomial Logistic Regression Analyses were used to assess the association between smoking cessation and trajectory membership. Results: The sample (55-85 years at baseline) consisted of 20.3% early quitters, 22.9% late quitters, and 56.8% continued smokers. After adjustment for confounders, the model showed that late quitters were less likely to follow an early decline trajectory instead of a successful trajectory compared to continued smokers (odds ratio [OR] = 0.48, 95% confidence interval [CI] = 0.24-0.97). After adjustment for clinically relevant level of depressive symptoms, this association remained substantial but was no longer statistically significant (OR = 0.50, 95% CI = 0.24-1.02). Conclusions: Although not statistically significant in the full model, the observed associations suggest that smoking cessation in old age may have an important impact on daily functioning in old age.

Published
2018
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38. 'Tough times have become good times': Resilience in older adults with a low socioeconomic position

Author

Kok, Almar A.L., Van Nes, Fenna, Deeg, Dorly J.H., Widdershoven, Guy, Huisman, Martijn, Kok, Almar A.L., Van Nes, Fenna, Deeg, Dorly J.H., Widdershoven, Guy, and Huisman, Martijn

Abstract

Background and Objectives This qualitative study applied a resilience perspective to socioeconomic inequalities in the functioning of older adults. We aimed to gain insight into how some older adults managed to age successfully despite having a low socioeconomic position (SEP) throughout their lives. Research Design and Methods Semistructured interviews were conducted with 11 resilient adults over the age of 79 years participating in the Longitudinal Aging Study Amsterdam, the Netherlands. Participants were defined as resilient on the basis of having a low lifetime SEP and favorable trajectories of physical, mental, and social functioning. Grounded Theory coding techniques were applied to identify themes reflecting distinct ways in which participants dealt with what they indicated were the most significant adversities in their lives. The analysis focused on experiences linked to socioeconomic conditions. Results Six themes reflecting psychological, behavioral, and social factors were derived from the data: drawing support from social contacts; investing in younger generations; taking actions to manage or improve socioeconomic conditions; putting the impact of a low SEP into perspective; persevering; and resigning oneself to adversity. Discussion and Implications Findings suggest that successful aging despite a low SEP throughout one's lifetime requires considerable psychological and social resources. In addition, resignation and specific manifestations of generativity are identified as new elements of resilience. These findings may help to reduce the stereotyping of older adults with a low SEP, and nuance the heroic image of resilience as something that is primarily attributable to extraordinary individual abilities or efforts.

Published
2018
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39. Reciprocal associations between depressive symptoms and satisfaction with sexual life in older adults: the roles of gender and importance attached to sexuality.

Author

Schutter, Natasja, Holwerda, Tjalling J., Kok, Almar A.L., and Deeg, Dorly J. H.

Subjects
*SEXUAL excitement, *GENERALIZED estimating equations, *DEPRESSION in men, *MENTAL depression, *SEXUAL intercourse
Abstract

AbstractObjectivesMethodResultsConclusionTo gain insight into the longitudinal, reciprocal associations between depressive symptoms and sexual satisfaction as well as the potential moderating roles of gender and perceived importance of sexuality.We analyzed longitudinal data from 2113 participants of the Longitudinal Ageing Study Amsterdam (LASA) with an initial age range of 54–93 years, using Generalized Estimating Equations (GEE).There were no significant associations between baseline depressive symptoms and change in sexual satisfaction, nor between baseline sexual satisfaction and change in depressive symptoms. Gender and perceived importance of sexuality were moderators: in men higher depression scores were associated with a decrease in sexual satisfaction, whereas in women higher depression scores were associated with an increase in sexual satisfaction. In participants for whom sexual life was important, higher depression scores were associated with a decrease in sexual satisfaction. In participants for whom sexual life was not important, higher depression scores were associated with an increase in sexual satisfaction.The associations between baseline depressive symptoms and change in sexual satisfaction as well as between baseline sexual satisfaction and change in depressive symptoms varied according to gender and importance ascribed to sexuality. Potential explanations might lie in the different roles sexual activity plays in sexual satisfaction in men and women. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Plasma biomarkers of endothelial dysfunction and cognition: an IPD meta-analysis of cross- sectional data from 9,344 individuals from seven Dutch cohorts

Author

Beran, Magdalena, Jansen, Willemijn J., Oomens, Julie E., Moonen, Justine E.F., Visser, Pieter Jelle, Huisman, Martijn A., Kok, Almar A.L., Nooyens, Astrid C.J., Verschuren, W.M. Monique, Stehouwer, Coen D.A., Schalkwijk, Casper, Köhler, Sebastian, van Boxtel, Martin, Beekman, Marian, Slagboom, P. Eline, Wolters, Frank J., Ikram, M. Arfan, Vallerga, Costanza L., van Meurs, Joyce B.J., Ghanbari, Mohsen, Vonk, Jet M.J., Geerlings, Mirjam I., van Sloten, Thomas T., and Schram, Miranda T.

Abstract

Endothelial dysfunction has various detrimental effects on the brain that may lead to cognitive decline. However, data on the direct association between endothelial dysfunction and cognitive performance in humans are scarce. The aim of the present study was to assess the cross-sectional association between plasma biomarkers of endothelial dysfunction and cognitive performance.

Published
2024
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