65 results on '"Koji Seki"'
Search Results
2. [Successful Pulmonary Embolectomy using a Bronchoscope:Report of a Case]
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Rina, Ebe, Masami, Sotokawa, Yushi, Katagiri, Shota, Nakagaki, Shingo, Otaka, Koji, Seki, Tetsuyuki, Ueda, Hideki, Shinno, and Hideki, Miyazawa
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Male ,Echocardiography ,Acute Disease ,Humans ,Thrombosis ,Embolectomy ,Pulmonary Embolism ,Aged - Abstract
Surgical pulmonary embolectomy is indicated for acute massive pulmonary thromboembolism complicated by floating thrombi in the right heart system. Postoperative residual thrombi are associated with persistent pulmonary hypertension and subsequent right heart failure, resulting in poor surgical outcome. A 67-year-old man was admitted to our institution owing to dyspnea on exertion. Transthoracic echocardiography revealed a floating right atrial mass and right ventricular overload. In addition, enhanced computed tomography (CT) showed a right atrial mass as well as bilateral massive pulmonary embolism. We performed an urgent pulmonary embolectomy using a bronchoscope as an adjunctive angioscope to completely remove the peripheral thrombi and to prevent serious complications, such as endobronchial hemorrhage due to pulmonary arterial injury. A clear, bloodless view of peripheral pulmonary arteries was obtained using short intermittent circulatory arrest technique. Postoperative course was uneventful, and he was discharged ambulatory 20 days after the surgery without any symptoms.
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- 2022
3. Mode-dependent magnonic noise
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Ryo Furukawa, Shoki Nezu, Takuro Eguchi, and Koji Sekiguchi
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Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biotechnology ,TP248.13-248.65 - Abstract
Abstract The performance of magnonic devices such as converters, switches, and multiplexers greatly depends on magnonic noise. While a peculiar discrete magnonic noise has been previously reported, the sources of underlying magnon dynamics occurring in high-magnon density conditions have not been clarified. Here, zero-span measurements of the spectrum analyzer were recorded to accurately detect magnonic noise as a fluctuation of the spin-wave amplitude. The results of low-frequency magnonic noise demonstrated a spin-wave mode dependency, indicating the existence of a peculiar magnon surface state. Furthermore, the energy thresholds of four-magnon scattering and autooscillation were determined using magnonic white noise. The noise data obtained in this study can help promote theoretical and experimental research on magnons.
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- 2024
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4. B-cell immune dysregulation with low soluble CD22 levels in refractory seronegative myasthenia gravis
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Yuumi Okuzono, Shuuichi Miyakawa, Tatsuo Itou, Masaki Sagara, Masashi Iwata, Kei Ishizuchi, Koji Sekiguchi, Haruhiko Motegi, Munenori Oyama, Dnyaneshwar Warude, Yusuke Kikukawa, and Shigeaki Suzuki
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myasthenia gravis ,single-cell RNA-sequencing ,immune dysregulation ,B cell ,soluble CD22 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Myasthenia gravis (MG), primarily caused by acetylcholine receptor (AChR) autoantibodies, is a chronic autoimmune disorder causing severe muscle weakness and fatigability. In particular, seronegative MG constitutes 10%–15% of MG cases and presents diagnostic challenges especially in early-onset female patients who often show severe disease and resistance to immunosuppressive therapy. Furthermore, the immunopathology of seronegative MG remains unclear. Thus, in this study, we aimed to elucidate the pathogenic mechanism of seronegative MG using scRNA-seq analysis and plasma proteome analysis; in particular, we investigated the relationship between immune dysregulation status and disease severity in refractory seronegative MG. Employing single-cell RNA-sequencing and plasma proteome analyses, we analyzed peripheral blood samples from 30 women divided into three groups: 10 healthy controls, 10 early-onset AChR-positive MG, and 10 refractory early-onset seronegative MG patients, both before and after intravenous immunoglobulin treatment. The disease severity was evaluated using the MG-Activities of Daily Living (ADL), MG composite (MGC), and revised 15-item MG-Quality of Life (QOL) scales. We observed numerical abnormalities in multiple immune cells, particularly B cells, in patients with refractory seronegative MG, correlating with disease activity. Notably, severe MG cases had fewer regulatory T cells without functional abnormalities. Memory B cells were found to be enriched in peripheral blood cells compared with naïve B cells. Moreover, plasma proteome analysis indicated significantly lower plasma protein levels of soluble CD22, expressed in the lineage of B-cell maturation (including mature B cells and memory B cells), in refractory seronegative MG patients than in healthy donors or patients with AChR-positive MG. Soluble CD22 levels were correlated with disease severity, B-cell frequency, and RNA expression levels of CD22. In summary, this study elucidates the immunopathology of refractory seronegative MG, highlighting immune disorders centered on B cells and diminished soluble CD22 levels. These insights pave the way for novel MG treatment strategies focused on B-cell biology.
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- 2024
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5. Ventral hernia repair with enhanced-view totally extraperitoneal technique after a massive weight loss by laparoscopic sleeve gastrectomy
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Manabu Amiki, Yasuhiro Ishiyama, Ichitaro Mochizuki, Kazuhiro Narita, Manabu Goto, and Koji Sekikawa
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Ventral hernia ,eTEP ,Laparoscopic sleeve gastrectomy ,Metabolic and bariatric surgery ,Surgery ,RD1-811 - Abstract
Abstract Background Ventral hernia repair (VHR) for obese patients is often associated with an increased risk of postoperative complications and hernia recurrences. Achieving preoperative weight loss is ideal before VHR; however, it is difficult to attain with medical treatment. Metabolic and bariatric surgery (MBS) offers the most effective and durable treatment for obesity. Therefore, massive weight loss occurring after MBS will improve the outcome of VHR. Case presentation A 49-year-old man (122.9 kg, BMI 39.1 kg/m2) presented to our hospital wishing to undergo laparoscopic sleeve gastrectomy and VHR. Physical examination revealed a tennis ball-sized lower midline defect. Computed tomography (CT) scans revealed a hernia orifice 5 cm in width and 10 cm in height. As the hernia orifice was large, mesh reinforcement was essential. We planned for him to undergo VHR after massive weight loss was achieved by MBS. VHR was performed using the enhanced-view totally extraperitoneal (eTEP) technique after weight loss of 38 kg was achieved 9 months following laparoscopic sleeve gastrectomy. His postoperative course was uneventful, and neither recurrence nor seroma was observed at 1 year follow-up. Conclusions eTEP repair of a ventral hernia after massive weight loss following MBS would appear to be the best combination treatment for obese patients with ventral hernias. However, long-term follow-up is necessary to establish its safety and efficacy.
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- 2023
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6. Real-world evidence of galcanezumab for migraine treatment in Japan: a retrospective analysis
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Tsubasa Takizawa, Seiya Ohtani, Narumi Watanabe, Naoki Miyazaki, Kei Ishizuchi, Koji Sekiguchi, Chisato Iba, Mamoru Shibata, Ryo Takemura, Satoko Hori, and Jin Nakahara
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Galcanezumab ,Migraine ,Real-world evidence ,Associated symptoms ,Premonitory symptoms ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective To evaluate the efficacy and safety of galcanezumab in patients with migraine in a real-world setting in Japan. Background Galcanezumab is the first anti-calcitonin gene-related peptide monoclonal antibody approved in Japan. To the best of our knowledge, no real-world studies on galcanezumab have been published in any international journal from Japan. Methods We retrospectively examined patients with migraine who received three doses of galcanezumab between August 2021 and February 2022 at the Keio University Hospital. We assessed changes in monthly migraine days, responder rate, and migraine-associated and premonitory symptoms. We also investigated injection site reactions and adverse events. Results Fifty-two patients received three doses of galcanezumab during the study period. Compared with those at baseline, the monthly migraine days decreased by 5.9 days (95% confidence interval, 4.2–7.7) at 3 months. The 50% responder rate was 61.5% at 3 months. A total of 64.9%, 50.0%, and 63.9% of patients showed improvement in the severity of photophobia, phonophobia, and nausea/vomiting, respectively. Premonitory symptoms without subsequent headache were reported in 62.5% of patients. Moreover, injection site reaction was the most common adverse event (34.6%). Conclusion This study revealed the efficacy and safety of galcanezumab for migraineurs in Japan. Galcanezumab also improved migraine-associated symptoms. However, despite a reduction in headaches, premonitory symptoms without subsequent headache were reported in > 50% of the patients at 3 months.
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- 2022
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7. Endovascular Treatment for Ureteroarterial Fistula in the Anastomotic Site of the Right Prosthetic Leg and Common Iliac Artery after Y-Graft Replacement for Abdominal Aortic Aneurysm
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Koji Seki
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medicine.medical_specialty ,business.industry ,medicine.artery ,Fistula ,medicine ,Radiology ,Anastomosis ,Endovascular treatment ,medicine.disease ,business ,Common iliac artery ,Abdominal aortic aneurysm - Published
- 2013
8. Thyroglobulin Gene Mutations Producing Defective Intracellular Transport of Thyroglobulin Are Associated with Increased Thyroidal Type 2 Iodothyronine Deiodinase Activity
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Yoshiharu Murata, Tetsuro Nagasaka, Akira Hishinuma, Yutaka Mizuno, Katsuhiko Tsunekawa, Yasuhiko Kanou, Masami Murakami, Chizumi Yamada, Tamio Ieiri, Haruki Fujisawa, Tsuneo Imai, Koji Seki, and Yoshitaka Miura
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Adult ,Male ,medicine.medical_specialty ,Goiter ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Clinical Biochemistry ,Deiodinase ,Thyroid Gland ,DIO2 ,Kidney ,Iodide Peroxidase ,Thyroglobulin ,Biochemistry ,Cell Line ,Endocrinology ,Thyroid peroxidase ,Internal medicine ,medicine ,Humans ,biology ,Genetic Carrier Screening ,Biochemistry (medical) ,Thyroid ,Biological Transport ,medicine.disease ,medicine.anatomical_structure ,Amino Acid Substitution ,Iodothyronine deiodinase ,Mutation ,biology.protein ,RNA ,Intracellular - Abstract
Context: Most patients with defective synthesis and/or secretion of thyroglobulin (Tg) present relatively high serum free T3 (FT3) concentrations with disproportionately low free T4 (FT4) resulting in a high FT3/FT4 ratio. The mechanism of this change in FT3/FT4 ratio remains unknown. Objective: We hypothesize that increased type 2 iodothyronine deiodinase (D2) activity in the thyroid gland may explain the higher FT3/FT4 ratio that is frequently observed in patients with abnormal Tg synthesis. Design: We recently identified a compound heterozygous patient (patient A) with a Tg G2356R mutation and one previously described (C1245R) that is known to cause a defect in intracellular transport of Tg. In the current study, after determining the abnormality caused by G2356R, we measured D2 activity as well as its mRNA level in the thyroid gland. We also measured the thyroidal D2 activity in three patients with Tg transport defect and in normal thyroid tissue. Results: Morphological and biochemical analysis of the thyroid gland from patient A, complemented by a pulse-chase experiment, revealed that G2356R produces a defect in intracellular Tg transport. D2 activity but not type 1 deiodinase in thyroid glands of patients with abnormal Tg transport was significantly higher than in normal thyroid glands, whereas D2 mRNA level in patient A was comparable with that in normal thyroid glands. Furthermore, there was a positive correlation between D2 activity and FT3/FT4 ratios. Conclusion: Increased thyroidal D2 activity in the thyroid gland is responsible for the higher FT3/FT4 ratios in patients with defective intracellular Tg transport.
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- 2007
9. Effect of a High-fat Diet on Diabetic Mother Rats and Their Offspring through Three Generations
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Masami Murakami, M Nara, Ritsuko Nasu, Koji Seki, and Tomoko Kohama
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Blood Glucose ,Male ,medicine.medical_specialty ,Offspring ,Endocrinology, Diabetes and Metabolism ,Pregnancy in Diabetics ,Triglyceride level ,Kidney ,Diabetes Mellitus, Experimental ,Endocrinology ,Pregnancy ,Internal medicine ,Diabetes mellitus ,Animals ,Medicine ,Weaning ,Rats, Wistar ,Pancreas ,Triglycerides ,Fetal Growth Retardation ,business.industry ,Body Weight ,Heart ,Organ Size ,Stillbirth ,medicine.disease ,Dietary Fats ,Rats ,Liver ,Fat diet ,Prenatal Exposure Delayed Effects ,Gestation ,Female ,Three generations ,business ,Blood Flow Velocity - Abstract
Pregnant diabetic Wistar rats were fed a high-fat diet starting at the first gestational day. The effect of the high-fat diet on the growth of the female, her offspring, and the offspring's offspring was studied. Pregnant rats (first generation) were divided into the Diabetic streptozotocin-induced group and the control group. Diabetic streptozotocin-induced rats and control rats were fed either a control diet (5% fat in diet) or high-fat diet (32% fat in diet), and observed up to the third generation. In each generation, after weaning, the pups were fed the respective diet. The fat content was mainly animal lard. Diabetic rats fed the high-fat diet were infertile, and the pregnant first-generation and diabetic rats fed the control diet had a stillbirth rate of 27.5 +/- 22.0% (mean +/- SE). In the first generation, the diabetic rats fed the control diet had a significantly lower body weight increase during the pregnancy than the control rats fed the control diet. The second-generation diabetic rats fed the control diet had a high blood glucose level at birth, and their triglyceride level was higher than that in the other two groups. The third-generation diabetic rats fed the control diet had a triglyceride level higher than that of control rats. Delivery was most difficult in diabetic rats fed the high-fat diet. Pups of diabetic rats fed the control diet had growth retardation and increased blood glucose levels. We conclude that when the mother rat had diabetes, the next generation was also affected.
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- 2007
10. Inferior vena cava thrombosis associated with a distended ileal neobladder
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Yasushi Terasaki, Koichi Kodama, Koji Seki, Isamu Motoi, Yasukazu Takase, and Hiroki Tatsu
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Male ,medicine.medical_specialty ,Vena Cava, Inferior ,Urologic Surgical Procedure ,Inferior vena cava ,Venous stasis ,Internal Medicine ,medicine ,Humans ,cardiovascular diseases ,Thrombus ,Venous Thrombosis ,business.industry ,Warfarin ,General Medicine ,Middle Aged ,medicine.disease ,Thrombosis ,Surgery ,Venous thrombosis ,medicine.vein ,cardiovascular system ,Urologic Surgical Procedures ,Inferior vena cava thrombosis ,business ,Tomography, X-Ray Computed ,medicine.drug - Abstract
Venous stasis is generally accepted to be a predisposing factor for venous thrombosis. However, benign causes of inferior vena cava (IVC) obstruction with associated thrombus formation have not been well described. We herein present a case of IVC compression caused by a distended ileal neobladder measuring 2,000 mL in capacity that led to IVC thrombosis. Following transurethral drainage for six weeks and anticoagulation therapy with warfarin for six months, the thrombus completely disappeared. The patient was considered to have a hypercoagulable state resulting from an acute urinary tract infection, a condition that may be associated with an increased risk of thrombosis.
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- 2015
11. Regulation of iodothyronine deiodinase and roles of thyroid hormones in human coronary artery smooth muscle cells
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Katsuhiko Tsunekawa, Masami Murakami, Masatomo Mori, Takayuki Kasahara, and Koji Seki
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Thyroid Hormones ,medicine.medical_specialty ,Platelet-derived growth factor ,Vascular smooth muscle ,Vasodilator Agents ,Deiodinase ,Coronary Artery Disease ,In Vitro Techniques ,Iodide Peroxidase ,Muscle, Smooth, Vascular ,chemistry.chemical_compound ,Cell Movement ,Internal medicine ,Cyclic AMP ,medicine ,Humans ,RNA, Messenger ,Cells, Cultured ,Platelet-Derived Growth Factor ,Triiodothyronine ,biology ,DNA synthesis ,Blotting, Northern ,Coronary Vessels ,Epoprostenol ,Endocrinology ,Gene Expression Regulation ,chemistry ,Iodothyronine deiodinase ,biology.protein ,Cardiology and Cardiovascular Medicine ,Platelet-derived growth factor receptor ,Hormone - Abstract
Thyroid hormones have been reported to have significant effects on the peripheral vascular system, including relaxation of vascular smooth muscle cells and prevention of atherosclerosis. To exert its biological activity, thyroxine (T4) needs to be converted to 3,5,3'-triiodothyronine (T3) by type 1 and type 2 iodothyronine deiodinases. We have previously identified type 2 iodothyronine deiodinase (D2) expression in cultured human coronary artery smooth muscle cells (hCASMCs). In the present study, we have characterized the regulation of D2 expression in hCASMCs by stable prostacyclin analogue beraprost sodium (BPS) and platelet derived growth factor (PDGF), and the roles of thyroid hormones in the functions of hCASMCs. BPS increased D2 expression, whereas PDGF suppressed BPS stimulated D2 expression without affecting cAMP production in hCASMCs. PDGF increased DNA synthesis, while BPS, T3 or T4 suppressed PDGF stimulated DNA synthesis in hCASMCs. Inhibition of D2 activity by 3,3',5'-triiodothyronine (rT3) partially restored T4 suppression of PDGF stimulated DNA synthesis in hCASMCs. PDGF increased migration activity, whereas BPS, T3 or T4 suppressed PDGF stimulated migration activity of hCASMCs. These results suggest that D2 expression is increased by BPS and suppressed by PDGF in hCASMCs, and that intracellular thyroid hormone activation may be involved in the suppression of DNA synthesis and migration activity of hCASMCs.
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- 2006
12. Conjugated estrogen plus medroxyprogesterone does not impair blood rheological properties in hypertensive postmenopausal women
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Shuichi Ichikawa, Hiroyuki Sumino, M Nara, Hironosuke Sakamoto, S. Koya, Masahiko Kurabayashi, Koji Seki, Takashi Takahashi, Masami Murakami, K. Goto-Onozato, and Tsugiyasu Kanda
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Medroxyprogesterone ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Urology ,Hemodynamics ,General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,medicine ,Humans ,Medroxyprogesterone acetate ,Single-Blind Method ,Blood Coagulation ,Antihypertensive Agents ,Aged ,Whole blood ,Hemostasis ,Estrogens, Conjugated (USP) ,business.industry ,Microcirculation ,Estrogen Replacement Therapy ,Obstetrics and Gynecology ,Hormone replacement therapy (menopause) ,Blood flow ,Middle Aged ,medicine.disease ,Postmenopause ,Menopause ,Treatment Outcome ,Endocrinology ,Estrogen ,Hypertension ,Female ,business ,Blood Flow Velocity ,medicine.drug - Abstract
Objectives Hypertension and estrogens are both prothrombotic. We used the microchannel method to investigate whether hormone replacement therapy (HRT) with conjugated equine estrogen (CEE) plus medroxyprogesterone acetate (MPA) affects blood flow through the microchannels in hypertensive postmenopausal women being treated with antihypertensive drugs and in normotensive postmenopausal women. Methods Sixty-two consecutive postmenopausal women were randomly assigned to a hypertensive HRT group ( n = 16), hypertensive control group ( n = 15), normotensive HRT group ( n = 16) and normotensive control group ( n = 15). Each HRT group received CEE 0.625 mg plus MPA 2.5 mg daily orally for 12 months. Both hypertensive groups were being treated with antihypertensive drugs before the study. Microvascular blood flow was assessed on the basis of blood passage time, the time required for 100 μl of whole blood to pass through a cylinder, was determined before and 12 months after the start of HRT by the microchannel method (micro channel array flow analyzer). Results CEE plus MPA therapy did not change blood passage time in any of the groups. Microscopic observation showed that the whole blood passed smoothly through the microchannels in every group. Conclusions CEE plus MPA therapy may not impair blood flow through the microchannels in hypertensive postmenopausal women receiving antihypertensive drugs or in normotensive postmenopausal women. However, administration of CEE plus MPA to postmenopausal women with hypertension warrants caution against the occurrence of thromboembolic events.
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- 2006
13. A new model of focal cerebral ischemia in the miniature pig
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Hideaki, Imai, Kenjiro, Konno, Mitsunobu, Nakamura, Tatsuya, Shimizu, Chisato, Kubota, Koji, Seki, Fumiaki, Honda, Shinichiro, Tomizawa, Yukitaka, Tanaka, Hidekazu, Hata, and Nobuhito, Saito
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Male ,Disease Models, Animal ,Middle Cerebral Artery ,Random Allocation ,Swine ,Animals ,Reproducibility of Results ,Swine, Miniature ,General Medicine ,Immunohistochemistry ,Magnetic Resonance Imaging ,Brain Ischemia ,Osteotomy - Abstract
The purpose of this set of studies is to design a minimally invasive, reproducible stroke model in the gyrencephalic brain. This paper provides information on both surgical technique and methods of quantification of ischemic damage to both gray and white matter in the miniature pig.Sixteen male miniature pigs were randomly divided into three groups and underwent transcranial surgery involving a frontotemporal approach with orbital rim osteotomy for permanent middle cerebral artery occlusion (MCAO; five animals), permanent internal carotid artery occlusion (ICAO; six animals), and a sham operation (five animals). Histological mapping and magnetic resonance (MR) imaging were used to delineate the areas of ischemic damage. The volumes of infarction measured directly from MR images were 16.2 +/- 1.1, 1.5 +/- 0.5, and 0.0 +/- 0.0 cm3 (mean +/- standard deviation [SD], p0.001) in the MCAO, ICAO, and sham-operated groups, respectively. The areas of ischemia identified through histological analysis and MR imaging showed a good correlation (r2 = 0.86, p0.0001). Immunohistochemical staining with an amyloid precursor protein (APP) antibody was used to evaluate axonal damage and calculate a total APP score for axonal damage of 44.8 +/- 2.9 in the MCAO, 13.2 +/- 6.6 in the ICAO, and 0.0 +/- 0.0 (mean +/- SD, p0.002) in the sham-operated animals.This new model of focal cerebral ischemia induces a reproducible amount of ischemic damage in both gray and white matter, and has significant utility for studies of the pathophysiology of ischemia in the gyrencephalic brain and for assessment of the therapeutic efficacy of drugs prior to the initiation of human clinical trials.
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- 2006
14. Effect of Antihypertensive Therapy on Blood Rheology in Patients with Essential Hypertension
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K. Goto-Onozato, Tsugiyasu Kanda, Takashi Takahashi, Masahiko Kurabayashi, Koji Seki, Shuichi Ichikawa, Hiroyuki Sumino, Masami Murakami, M Nara, and S. Koya
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Platelet Aggregation ,Platelet aggregation ,Blood Pressure ,030204 cardiovascular system & hematology ,Pharmacology ,Essential hypertension ,Biochemistry ,03 medical and health sciences ,Blood Circulation Time ,0302 clinical medicine ,Internal medicine ,Cell Adhesion ,Leukocytes ,Humans ,Medicine ,In patient ,Circadian rhythm ,Risk factor ,Antihypertensive Agents ,Aged ,Whole blood ,Aged, 80 and over ,business.industry ,Biochemistry (medical) ,Arteries ,Cell Biology ,General Medicine ,Middle Aged ,medicine.disease ,Circadian Rhythm ,Blood pressure ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Hypertension ,Cardiology ,Female ,Rheology ,business ,Blood Flow Velocity - Abstract
Hypertension is an important risk factor for cardiovascular disease, and antihypertensive drugs can decrease the occurrence of such events in hypertensive patients. This study compared the rheological properties of blood in 22 untreated hypertensive patients, 42 patients taking antihypertensive drugs and 74 normotensive subjects. Using a microchannel method, the whole blood passage time was measured and blood movement was observed with a microscope connected to an image display unit. The blood passage time in untreated hypertensive patients was significantly higher than in treated hypertensive patients or normotensive subjects, but was similar in the latter two groups. Microscopic observations showed that platelet aggregation and leucocyte adhesion were increased in untreated hypertensive patients, resulting in poor flow, while blood samples from treated hypertensive patients and normotensive subjects passed smoothly through the microchannels. These rheological differences could contribute to the decrease in cardiovascular disease seen when hypertensive patients are treated effectively.
- Published
- 2005
15. Association of Antipituitary Antibody and Type 2 Iodothyronine Deiodinase Antibody in Patients with Autoimmune Thyroid Disease
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Katsuhiko Tsunekawa, Isao Kobayashi, Takayuki Kasahara, M Nara, Masami Murakami, Koji Seki, Shigeki Yabe, Michio Nishino, Takayuki Ogiwara, and Rieko Nakahara
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Adult ,Male ,endocrine system ,Pituitary gland ,medicine.medical_specialty ,Adolescent ,endocrine system diseases ,Hashimoto's disease ,Endocrinology, Diabetes and Metabolism ,Graves' disease ,education ,Thyroid Gland ,Enzyme-Linked Immunosorbent Assay ,Hashimoto Disease ,Iodide Peroxidase ,Endocrinology ,Antigen ,Internal medicine ,mental disorders ,medicine ,Humans ,Immunoprecipitation ,Child ,Aged ,Autoantibodies ,Aged, 80 and over ,biology ,business.industry ,Thyroid ,Case-control study ,Middle Aged ,medicine.disease ,Graves Disease ,medicine.anatomical_structure ,Case-Control Studies ,Pituitary Gland ,Iodothyronine deiodinase ,Immunology ,biology.protein ,Female ,Antibody ,business ,psychological phenomena and processes - Abstract
Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gland homogenate and D2 peptide were used as antigens in the present study. APA and D2 peptide antibodies were measured by enzyme-linked immunosorbent assay (ELISA) in sera obtained from 42 patients with Hashimoto's disease, 26 patients with Graves' disease and 70 healthy control subjects. Moreover, D2 activity precipitation assay was performed in some patients with Hashimoto's disease. APA and D2 peptide antibody were elevated in patients with Hashimoto's disease and patients with Graves' disease, compared with control subjects. APA was positive in 32.4% (22/68), D2 peptide antibody was positive in 26.5% (18/68) of patients with autoimmune thyroid disease. APA was positive in 31.0% (13/42) of patients with Hashimoto's disease and 34.6% (9/26) of patients with Graves' disease. D2 peptide antibody was positive in 26.2% (11/42) of patients with Hashimoto's disease and 26.9% (7/26) of patients with Graves' disease. D2 peptide antibody was correlated with APA in patients with autoimmune thyroid disease. Moreover, precipitation of D2 activity was increased in some patients with Hashimoto's disease including a patient who also had idiopathic diabetes insipidus, and was correlated with D2 peptide antibody. These results suggest that D2 antibody may be associated with APA in patients with autoimmune thyroid disease.
- Published
- 2005
16. INFLUENCE OF SLUDGE RATIO AND TEMPERATURE ON THE INTEGRATED METHANE FERMENTATION OF ORGANIC FRACTION OF MUNICIPAL SOLID WASTE AND BIOSLUDGE
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Ikuo Kamigochi, Hiroshi Sasaki, Yoshio Okuno, Koji Seki, and Yu-You Li
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Municipal solid waste ,Methane fermentation ,Waste management ,Environmental science ,Organic fraction ,Mesophile - Abstract
生ごみと汚泥の比率を0, 10, 25, 50%で変化させて投入TS濃度12~13%, HRT15日で高温および中温メタン発酵の連続実験を行った. TS分解率は汚泥比率の増加に伴って高温発酵で30~74%, 中温発酵で30~67%減少した. 生ごみ, 汚泥の元素分析結果からし尿汚泥中に微量栄養塩 (Fe, Ni, Co) が含有しており, 汚泥比率25, 50%では, 微量金属の添加無しでメタン発酵が可能であった. 加水分解速度, 酸生成速度およびメタン生成速度は, 汚泥比率の増加とともにいずれも低下していた. 高温発酵と中温発酵を比較すると, 加水分解, 酸生成速度では高温発酵の方が速いが, メタン生成速度では差がほとんどなく, ほぼ同等であった. 高温発酵ではNH4+-N濃度が2,700~2900mg/L, と比較的高く, アンモニアの部分的阻害によるVFA蓄積が見られた.
- Published
- 2003
17. Influence of the Sludge Ratio on the High-solids Thermophilic Methane Fermentation of the Organic Fraction of Municipal Solid Waste and Bio-sludge
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Ikuo Kamigochi, Yu You Li, Koji Seki, Yoshio Okuno, and Hiroshi Sasaki
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Municipal solid waste ,Methane fermentation ,Waste management ,Thermophile ,Environmental science ,Thermal hydrolysis ,Organic fraction - Published
- 2003
18. Pick's disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic system
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Kaoru Okuizumi, Koji Seki, Akiyoshi Kakita, Koichi Wakabayashi, Hitoshi Takahashi, Osamu Onodera, Shoji Tsuji, Hajime Tanaka, Keisuke Iwanaga, Masaharu Tanaka, and Shigenobu Hayashi
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Male ,Apolipoprotein E ,medicine.medical_specialty ,Pathology ,Genotype ,Biology ,Pathology and Forensic Medicine ,Central nervous system disease ,Pathogenesis ,Cellular and Molecular Neuroscience ,Apolipoproteins E ,Limbic system ,Degenerative disease ,Internal medicine ,Limbic System ,medicine ,Humans ,Aged ,Dentate gyrus ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Endocrinology ,medicine.anatomical_structure ,Dentate Gyrus ,Dementia ,Female ,lipids (amino acids, peptides, and proteins) ,Pick's disease ,Neurology (clinical) - Abstract
We carried out immunohistochemical examination of apolipoprotein E (apoE) in brains from two patients with Pick's disease. In these cases 1 and 2, the APOE genotypes were epsilon 3/4 and epsilon 3/3, respectively. In both cases, numerous argyrophilic globular intraneuronal inclusions, Pick bodies (PBs), were distributed widely throughout the brain, and immunohistochemically were occasionally positive for apoE. Interestingly, such apoE-immunoreactive PBs were virtually restricted to neurons in the limbic system; in the dentate gyrus, the proportion of apoE-immunoreactive PBs relative to the total number of argyrophilic PBs was 5.0% in case 1 and 2.7% in case 2, whereas in the frontal and temporal neocortices it was less than 0.1% in both cases. Diffuse cytoplasmic immunoreactivity for apoE was found in only a few limbic system neurons without PBs in both cases. In conclusion, it is considered that apoE may not be positively involved in the process of PB formation and that the preferential distribution of apoE-immunoreactive PBs in the limbic system may reflect the presence of certain regional factors associated with the synthesis or metabolism of apoE in this particular system.
- Published
- 1998
19. Movement of the sludge regeneration processing center. The basic examination on high-efficient methane fermentation technology of garbage and human waste sludge
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Yu You Li, Ikuo Kamigochi, Hiroshi Sasaki, Yoshio Okuno, and Koji Seki
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- 1998
20. Fifth organisms-utilizing new technology research symposium. Biological treatment of the halogenated acetic acid formed by UV degradation of TCE, etc
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Koji Seki and Keisuke Funaishi
- Published
- 1998
21. Novel functional polymers: Poly(dimethylsiloxane)-polyamide multiblock copolymer. III. Synthesis and surface properties of disiloxane-aromatic polyamide multiblock copolymer
- Author
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Akio Kishida, Mitsuru Akashi, Taka‐aki Ohshige, Tsutomu Furuzono, Koji Seki, Kazunori Waki, and Ikuro Maruyama
- Subjects
Materials science ,Polymers and Plastics ,Biocompatibility ,General Chemistry ,Disiloxane ,Surfaces, Coatings and Films ,Contact angle ,Aramid ,chemistry.chemical_compound ,chemistry ,X-ray photoelectron spectroscopy ,Polymer chemistry ,Polyamide ,Materials Chemistry ,Wetting ,Functional polymers - Abstract
Disiloxane–aromatic polyamide(aramid) multiblock copolymers(2SiPASs) were synthesized using 1,3-bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxane(BATS) as an analog of aramidsilicone resin consisting of aromatic polyamide and poly(dimethylsiloxane) (PDMS). 2SiPASs afford a transparent and toughened plastic film. The surface properties of 2SiPAS were investigated by X-ray photoelectron spectroscopy (xps) and static contact angle measurement. The results of surface analysis suggested that BATS content of the 2SiPAS surface increased with increasing BATS content in bulk. The interaction between the platelets and the 2SiPAS surface was found to be very weak when the BATS content reached 26 wt % in bulk. © 1996 John Wiley & Sons, Inc.
- Published
- 1996
22. Coexistence of Creutzfeldt-Jakob disease and senile dementia of the Alzheimer type
- Author
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Koji Seki, Koichi Wakabayashi, Fusahiro Ikuta, Masaharu Tanaka, Kaoru Hinokuma, and Hitoshi Takahashi
- Subjects
Pediatrics ,medicine.medical_specialty ,Pathology ,business.industry ,Spongiform change ,General Medicine ,Disease ,medicine.disease ,Aged patients ,nervous system diseases ,Pathology and Forensic Medicine ,mental disorders ,Medicine ,Dementia ,Neurology (clinical) ,Astrocytosis ,Senile plaques ,medicine.symptom ,Alzheimer's disease ,business ,Myoclonus - Abstract
An 88 year old woman with slowly progressive dementia of 5 years' duration experienced rapidly progressive consciousness disturbance, myoclonus and periodic synchronous discharge on electro-encephalography from 3 months before her death. Post-mortem examination revealed numerous senile plaques reactive with antibody against p-peptide and widespread occurrence of spongiform change, astrocytosis and marked neuronal loss in the entire cerebral cortex and amygdaloid nucleus. These findings indicate that Creutzfeldt-Jakob disease (CJD) and senile dementia of the Alzheimer type (SDAT) occurred in the same patient. As the number of aged patients with dementia in care homes and hospitals for the elderly is increasing, it is important to know that CJD can occur late in life during the course of SDAT, as shown in the present case.
- Published
- 1995
23. Contents, Vol 33, 1993 / Publisher's Note
- Author
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Laura Palmucci, A. Prelle, A. Toscano, Carlo Doriguzzi, Zin-An Wu, Yasuo Terao, Kouichi Takeda, Antonio Pietroiusti, Patrick J. Willems, A. Bordoni, Myung Sik Lee, Gabriele Siciliano, G. Vita, Johan Verheist, Vinchi Wang, Ritva K. Laaksonen, M. Clanet, Luigi Murri, Jürgen Bohl, Toshiki Uchihara, Paul M. Parizel, Kong-Pin Lin, Ko-Pei Kao, Jean-Jacques Martin, N. Checcarelli, C. Messina, Shun-Jiun Wang, Charles Mahler, Tadashi Miyatake, Alberto Galante, Manabu Sakuta, Tetsuo Nemoto, Mauro Sihestrini, A. Baradello, Ching-Piao Tsai, Mitsuru Kawai, Kwong-Kum Liao, Tiziana Mongini, Kazuyuki Ishida, Rauno A. Tuikka, Silvana Bundino, Loredana Chiadò-Piat, Erik Van de Kelft, Kiyotoshi Kaneko, Giorgio Bernardi, Tarniko Takemura, Hannu Somer, Gloria Tognoni, Roger Abs, Jan Verlooy, Valentina Guerrini, Eva Braak, Paolo Stanzione, Takashi Inuzuka, Bruno Domenici, Antonio Bertolotto, Koji Seki, Bruno Rossi, Tomio Kanda, Heiko Braak, Maria Zina, Eric Van Marck, Il Saing Choi, N. Bresolin, Michele Maniscalco, and Ferdinando Sartucci
- Subjects
Neurology ,Neurology (clinical) - Published
- 1993
24. Transition metal-catalyzed radical cyclizations: a low-temperature process for the cyclization of N-protected N-allyltrichloroacetamides to trichlorinated .gamma.-lactams and application to the stereoselective preparation of .beta.,.gamma.-disubstituted .gamma.-lactams
- Author
-
Koji Seki, Masayoshi Washiyama, Kenji Itoh, Hideo Nagashima, Nobuyasu Ozaki, and Masayuki Ishii
- Subjects
chemistry.chemical_classification ,Allylic rearrangement ,Stereochemistry ,Organic Chemistry ,Substituent ,Free-radical reaction ,Medicinal chemistry ,chemistry.chemical_compound ,Bipyridine ,chemistry ,Lactam ,Stereoselectivity ,Selectivity ,Alkyl - Abstract
Cyclizations of N-substituted N-allyltrichloroacetamides, where the substituent is an alkyl, Cbz, Boc, Ts, or Ms group, are catalyzed by a 1:1 mixture of CuCl and bipyridine to give the corresponding β,γ-trichlorinated γ-lactams in high yields. The reactions proceed at temperatures from -78 o C to room temperature. Cyclizations of N-allyltrichloroacetamides of acyclic secondary allylic amines are achieved with good selectivity; the cis/trans ratios of the γ-lactams formed were dependent on the substituents on the nitrogen atom
- Published
- 1993
25. Circulating Autoantibody to Mature Neurons and Astrocytes of Humans and Some Mammals Present in a Demented Patient with Autoimmune Disorder
- Author
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Koji Seki, Toshiki Uchihara, Tomio Kanda, Kiyotoshi Kaneko, Tadashi Miyatake, Takashi Inuzuka, and Kazuyuki Ishida
- Subjects
Male ,Biology ,Autoimmune Diseases ,Diagnosis, Differential ,Epitopes ,Alzheimer Disease ,medicine ,Animals ,Humans ,Dementia ,Nuclear protein ,Aged ,Autoantibodies ,Neurons ,Autoimmune disease ,Cerebrum ,Autoantibody ,Brain ,Nuclear Proteins ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,nervous system diseases ,Cell nucleus ,medicine.anatomical_structure ,nervous system ,Neurology ,Astrocytes ,Immunology ,Cattle ,Female ,Neurology (clinical) ,Neuron ,Neuroscience ,Astrocyte - Abstract
Circulating autoantibody to a 48-kD nuclear protein in neurons and astrocytes of the human and bovine cerebrum were present in the serum of a demented patient with an autoimmune disorder. Other human visceral organs, dorsal root ganglion cells, neuroblastoma and glioblastoma cell lines, and rat cerebrum did not react with the patient's serum. No sera from age-matched controls, including those with Alzheimer's disease, reacted with the 48-kD protein. Only the mature neurons and astrocytes of humans and some mammals express the 48-kD protein. This antibody may be responsible for the patient's demented condition.
- Published
- 1993
26. Effects of Salt Concentration on the Intracellular Cadmium Content of and the Cadmium Uptake by a Highly Cadmium-tolerant, Moderately HalophilicPseudomonassp
- Author
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Hiroshi Tokunaga, Takekazu Kobayashi, Koji Seki, and Hiroshi Onishi
- Subjects
Cadmium ,biology ,Organic Chemistry ,Pseudomonas ,chemistry.chemical_element ,General Medicine ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Biochemistry ,Halophile ,Analytical Chemistry ,Salinity ,chemistry ,Pseudomonadales ,Food science ,Molecular Biology ,Bacteria ,Intracellular ,Biotechnology ,Pseudomonadaceae - Abstract
The intracellular cadmium (Cd) content was measured with early stationary phase cells of a highly Cd-tolerant moderately halophilic bacterium Pseudomonas sp. No. 40 cultivated in 1M and 3M NaCl medium containing 0 to 2500 μg of CdCl2/ml. It was found that the Cd contents were greatly affected by the NaCl concentration of the medium. When the bacterium was cultivated in the 1, 2, 3, and 4M NaCl medium containing 1500 μg of CdCl2/ml, the intracellular Cd content was 25.0, 4.1, 3.1, and 2.0 mg Cd per g of dry cells, respectively. The intracellular Cd content decreased with increases of NaCl concentration of the medium. The fact seems to reflect Cd-tolerance of the bacterium towards the growth in the medium of different NaCl concentration. It is worthwhile to note that the bacterium showed the highest Cd-tolerance (in 3M NaCl) and the lowest Cd content among the bacteria so far known. The bacterial cells grown in the 1M NaNO3 and 1M Na2SO4 medium accumulated 1.8–1.3 times as much Cd2+ as those in the 1M NaCl ...
- Published
- 1993
27. Oxidative stress associated with rapid weight reduction decreases circulating adiponectin concentrations
- Author
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Yoshimaro Yanagawa, Shingo Matsumoto, Nobuo Kotajima, Tadashi Morimura, Takumi Adachi, Koji Seki, Katsuhiko Tsunekawa, Masami Murakami, Tetsuo Machida, and Takayuki Ogiwara
- Subjects
Adult ,Leptin ,Male ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Urinary system ,medicine.disease_cause ,Endocrinology ,Weight loss ,Internal medicine ,Weight Loss ,medicine ,Humans ,Testosterone ,Wrestling ,Adiposity ,Adiponectin ,business.industry ,Deoxyguanosine ,Bilirubin ,Pathophysiology ,Oxidative Stress ,8-Hydroxy-2'-Deoxyguanosine ,Nutrition physiology ,medicine.symptom ,business ,Oxidative stress ,Biomarkers - Abstract
The effect of stress associated with acute weight reduction on adipocytokine production is incompletely understood. In the present study, we have investigated the changes in circulating adipocytokine concentrations and urinary concentrations of stress markers in male collegiate wrestlers during acute weight reduction for a competition. Twenty healthy Japanese male wrestlers (18-22 years of age) who participated in the national collegiate wrestling tournament were studied. Body weight, body fat amount, serum testosterone, serum leptin, serum adiponectin, urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG) and urinary biopyrrins were analyzed during acute weight reduction for the competition. Body weight, body fat amount and the serum concentrations of testosterone, leptin and adiponectin significantly decreased on the day of weigh-in compared with the levels 12 days before weigh-in. In contrast, urinary concentrations of 8-OHdG and biopyrrins significantly increased on the day of weigh-in compared with the concentrations 12 days before weigh-in. A positive correlation was observed between the serum concentrations of adiponectin and testosterone, and a negative correlation was observed between the concentrations of serum adiponectin and urinary biopyrrins. The present results suggest that rapid weight reduction increases the urinary concentrations of stress markers, which is associated with a decrease in serum concentrations of adiponectin.
- Published
- 2010
28. Experimental investigation of encephalomyosynangiosis using gyrencephalic brain of the miniature pig: histopathological evaluation of dynamic reconstruction of vessels for functional anastomosis. Laboratory investigation
- Author
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Hideaki Imai, Koji Seki, Hidekazu Hata, Ahmad Faried, Sandra Puentes, Kenjiro Konno, Chisato Kubota, Hideaki Yokoo, Mitsunobu Nakamura, Nobuhito Saito, and Yuhei Yoshimoto
- Subjects
Carotid Artery Diseases ,medicine.medical_specialty ,Miniature pig ,Swine ,medicine.medical_treatment ,External carotid artery ,Neovascularization, Physiologic ,Temporal Muscle ,Anastomosis ,Revascularization ,medicine.artery ,Occlusion ,medicine ,Animals ,Moyamoya disease ,Cerebral Cortex ,Wound Healing ,medicine.diagnostic_test ,biology ,Cerebral Revascularization ,business.industry ,Anastomosis, Surgical ,General Medicine ,medicine.disease ,biology.organism_classification ,Magnetic Resonance Imaging ,Surgery ,Cerebral Angiography ,Angiography ,Swine, Miniature ,Radiology ,Moyamoya Disease ,business ,Cerebral angiography - Abstract
Object Encephalomyosynangiosis (EMS) is a surgical treatment for moyamoya disease that is widely used to provide increased intracranial blood flow via revascularization by arterial anastomosis from the external carotid artery. However, the angiogenic mechanism responsible for the revascularization induced by EMS has not been systematically evaluated. In this study the authors investigated the chronological angiogenic changes associated with EMS to clarify the favorable factors and identify revascularization mechanisms by using an experimental internal carotid artery occlusion (ICAO) model in the miniature pig. Methods Fourteen miniature pigs were used, 11 of which underwent ICAO before transcranial surgery for EMS was performed. Animals were allowed to recover for 1 week (4 pigs) or 4 weeks (7 pigs) after EMS. Control group animals were treated in the same way, but without occlusion (3 pigs). Magnetic resonance imaging, angiography, and histological investigation were performed. Results One week after EMS, on histological examination of both the ICAO and control groups it was found that the transplanted temporal muscle had adhered to the arachnoid via a granulation zone, which was enriched with immune cells such as macrophages associated with the angiogenic process. Four weeks after EMS, angiography and histological examination of the ICAO group showed patent anastomoses between the external carotid artery and the cortical arteries without any detectable boundary between the temporal muscle and the cerebral cortex. In contrast, histological examination of the control group found scar tissue between the cerebral cortex and temporal muscle. Conclusions The initial step for formation of anastomoses resembles the process of wound healing associated with repair processes such as active proliferation of macrophages and angiogenesis within the new connective tissue. Functional revascularization requires a suitable environment (such as tissue containing vascular beds) and stimulus (such as ischemia) to induce vascular expansion.
- Published
- 2009
29. Transition-metal-catalyzed radical cyclization: copper-catalyzed cyclization of allyl trichloroacetates to trichlorinated .gamma.-lactones
- Author
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Jiro Tsuji, Kenji Itoh, Hideo Nagashima, Koji Seki, Hidetoshi Wakamatsu, Yoichi Tomo, and Nobuyasu Ozaki
- Subjects
chemistry.chemical_classification ,Allylic rearrangement ,Bicyclic molecule ,Chemistry ,Organic Chemistry ,Diastereomer ,Free-radical reaction ,Organic chemistry ,Moiety ,Medicinal chemistry ,Radical cyclization ,Alkyl ,Lactone - Abstract
Various trichlorinated γ-lactones having a variety of alkyl substituents were prepared by title method. γ-Lactones were generally obtained as a single product exept the cyclization of methallyl trichloroacetate, which afforded a mixture of γ- and δ-lactones. The addition of a dichloracetyl moiety and a chlorine atom to olefins was not sterospecific. Trichloroacetates of secondary allylic alcohols provided a mixture of diastereomers. The stereochemical outcome was dependent on the structure of the starting trichloroacetates; 2-cyclohexenyl trichloroacetate gave the corresponding cis-fused bicyclic lactone, whereas the reaction of acyclic trichloroacetates derived from 1-buten-3-ol and its analogues generally provided the trans-substituted lactones
- Published
- 1990
30. Relationships between blood rheology and age, body mass index, blood cell count, fibrinogen, and lipids in healthy subjects
- Author
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Koji, Seki, Hiroyuki, Sumino, Misa, Nara, Nobuyoshi, Ishiyama, Michio, Nishino, and Masami, Murakami
- Subjects
Adult ,Male ,Adolescent ,Age Factors ,Fibrinogen ,Middle Aged ,Blood Viscosity ,Lipids ,Blood Cell Count ,Body Mass Index ,Blood Circulation ,Hemorheology ,Humans ,Female ,Blood Flow Velocity - Abstract
We investigated the relationships between blood rheology assessed by microchannel method and the various hemorheologic factors in healthy subjects. One hundred seventy-six healthy volunteers (90 men and 86 women, mean age; 32.9+/-11.3 years) were participated in this study. Body weight, body mass index, red blood cell count, hematocrit, hemoglobin, white blood cell count, and platelet count, plasma fibrinogen, and fasting serum lipid and lipoprotein concentrations were measured. In order to assess blood rheology, blood passage time was determined by a microchannel method (Micro Channel Array Flow Analyzer). Age, body mass index, red blood cell count, hematocrit, hemoglobin, white blood cell count, total cholesterol, low-density lipoprotein cholesterol, and triglyceride were positively correlated with blood passage time in all subjects, respectively (p0.01) and high-density lipoprotein cholesterol was inversely correlated with blood passage time (p0.01). However, platelet count, and fibrinogen were not correlated with blood passage time. The present study showed that increased age, body mass index, red blood cell count, white blood cell count, total cholesterol, low-density lipoprotein cholesterol, and triglyceride and decreased high-density lipoprotein cholesterol were associated with impaired blood rheology measured by microchannel method in healthy subjects, suggesting that aging, obesity, erythrocytosis, leukocytosis, and dyslipidemia may be related to hemorheological disorders. This microchannel method may be useful to study blood rheology which may be associated with various risk factors of cardiovascular disorders.
- Published
- 2006
31. Diode proximity-coupled Nd:GdVO4 planar waveguide laser
- Author
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Yoshihito Hirano, Masao Imaki, Syuhei Yamamoto, Koji Seki, and Takayuki Yanagisawa
- Subjects
Distributed feedback laser ,Materials science ,business.industry ,chemistry.chemical_element ,Laser ,Waveguide (optics) ,Neodymium ,law.invention ,Semiconductor laser theory ,Optical pumping ,Optics ,chemistry ,law ,Optical cavity ,Optoelectronics ,business ,Diode - Abstract
We demonstrated a compact linear-polarized planer waveguide laser with diode proximity-coupling pump geometry, and uniaxial laser material of Nd:GdVO4 The laser cavity size is as small as 4-mm times 1 mm including the 5-stripe pumping diode, the total output power of 1.7-W for five independent nearly diffraction- limited beams was obtained at the pumping diode output power of 5.7-W.
- Published
- 2006
32. Seasonal variations of CO and HCN in the troposphere measured by solar absorption spectroscopy over Poker Flat, Alaska
- Author
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Koji Seki, Yasuhiro Murayama, Akimitsu Fujiwara, Nicholas B. Jones, Frank J. Murcray, Yasuko Kasai, and A. Kagawa
- Subjects
Pollution ,Spectrometer ,Meteorology ,Infrared ,Solar spectra ,media_common.quotation_subject ,Solar absorption ,Atmospheric sciences ,Troposphere ,Geophysics ,General Earth and Planetary Sciences ,Environmental science ,Absorption (electromagnetic radiation) ,Spectroscopy ,media_common - Abstract
[1] Tropospheric partial column abundances of CO and HCN have been retrieved from infrared solar spectra observed with a ground-based spectrometer at Poker Flat Alaska (65°N, 147°W) over the time period from 2000 to 2004. From these data we report the transpacific transport induced inter-annual variability of tropospheric CO over Poker Flat. This is the first report of solar infrared data from the Poker Flat station, where the geographical location of the site means that remote sensing measurements are sampling the transport of transpacific air parcels going to Northern America from Eastern Siberia and Asia. The five year time-span of the data also show significant differences in year to year CO and HCN tropospheric column enhancements driven by changes in Siberian/Asian pollution sources.
- Published
- 2005
33. Unique regulation of thyroid hormone metabolism during fasting in the house musk shrew (Suncus murinus, Insectivora: Soricidae)
- Author
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Yoko Takeuchi, Daisuke Suzuki, Masami Murakami, Katsuhiko Tsunekawa, Takayuki Kasahara, Yoshiharu Murata, Koji Seki, Samuel Refetoff, and Sen-ichi Oda
- Subjects
medicine.medical_specialty ,Thyroid Hormones ,Deiodinase ,Biology ,Iodide Peroxidase ,Endocrinology ,Adipose Tissue, Brown ,Internal medicine ,biology.animal ,Brown adipose tissue ,medicine ,Animals ,RNA, Messenger ,Insectivora ,Shrews ,Shrew ,Thyroid ,Body Weight ,Suncus ,Fasting ,biology.organism_classification ,Thyroxine ,medicine.anatomical_structure ,Liver ,Cerebral cortex ,biology.protein ,Triiodothyronine ,Animal Science and Zoology ,Hormone - Abstract
The active hormone, 3,3′,5-triiodothyronine (T3) is derived from thyroxine (T4) by the action of iodothyronine 5′-deiodinases (5′-D). By now two types of 5′-D have been identified; Type 1 (D1) and type 2 (D2). A relative contribution of these isotypes to the circulating T3 levels in the human remains to be determined whereas a number of reports indicate that, under physiological conditions, D1 plays a major role in maintaining circulating T3 levels in rodents. In both human and rodents, sickness and starvation reduce serum T3 concentration mainly through decrease in D1 activity. Recently, we found that the house musk shrew (Suncus murinus, Insectivora: Soricidae) has a different tissue distribution of D1 activity. Because compared to rodents D1 activity in the shrew was found only in liver at a much reduced level, D2 rather than D1 may play a role in the maintenance of serum T3. Therefore, we questioned how D1 and D2 activities change in fasted shrews and how these changes affect circulating thyroid hormone levels. We thus starved shrews for 24, 48 or 72 h and measured changes in serum concentration of T3, T4, and 3,3′,5′-triiodothyronine (reverse T3, rT3) and D1 activities as well as its mRNA expression in liver. D2 activities were also measured in brown adipose tissue (BAT) and cerebral cortex of shrews. Unlike in human and rodents, T3 levels in shrews remained constant during fasting while T4 levels tended to decrease, resulting in an increase in its T3/T4 ratio. On the other hand, changes in rT3 levels were similar to those in human and rodents, being elevated with fasting. D1 mRNA and its activity were significantly reduced in the liver whereas D2 activities in BAT and cerebral cortex were increased by fasting. These results indicated that fasting in shrews also reduced hepatic D1 activity but it did not affect circulating T3 levels. The increased T3/T4 ratio together with increased D2 activity in BAT and cerebral cortex with fasting suggest that D2 rather than D1 is responsible for the maintenance of T3 levels in the house musk shrew.
- Published
- 2005
34. Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin
- Author
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Masami Murakami, Katsuhiko Tsunekawa, Masatomo Mori, Takayuki Ogiwara, Tadashi Morimura, Koji Seki, and Takayuki Kasahara
- Subjects
endocrine system ,medicine.medical_specialty ,Proteasome Endopeptidase Complex ,endocrine system diseases ,Deiodinase ,DIO2 ,Thyrotropin ,Biology ,Iodide Peroxidase ,Gene Expression Regulation, Enzymologic ,Thyrotropin receptor ,Endocrinology ,Thyroid-stimulating hormone ,Internal medicine ,Cell Line, Tumor ,medicine ,Cyclic AMP ,Humans ,Receptor ,Bone growth ,Osteoblasts ,Reverse Transcriptase Polymerase Chain Reaction ,Ubiquitin ,Osteoblast ,Receptors, Thyrotropin ,medicine.anatomical_structure ,Iodothyronine deiodinase ,biology.protein - Abstract
Thyroid hormones play important roles in bone growth, development, and turnover. To exert its biological activity, T(4) needs to be converted to T(3) by iodothyronine deiodinase. In human thyroid gland as well as rat brown adipose tissue, type 2 iodothyronine deiodinase (D2) expression is regulated by a TSH receptor-cAMP-mediated mechanism. TSH receptor knockout mice demonstrated the direct effects of TSH on bone via TSH receptors found on osteoblast and osteoclast precursors. In the present study we investigated the possible expression and function of iodothyronine deiodinase and TSH receptors in human osteoblast-like osteosarcoma (SaOS-2) cells and normal human osteoblast (NHOst) cells. Iodothyronine deiodinase activity was detected in SaOS-2 cells and NHOst cells, and all of the characteristics of deiodinating activity were compatible with those of D2. Northern analysis demonstrated D2 mRNA expression in SaOS-2 cells and NHOst cells. D2 mRNA levels as well as D2 activities were rapidly increased by dibutyryl cAMP or forskolin in SaOS-2 cells and NHOst cells. TSH receptor mRNA was demonstrated in SaOS-2 cells and NHOst cells, and D2 mRNA and D2 activity were stimulated by TSH in both cells. In addition, all T(3) receptor isoforms were detected by RT-PCR in SaOS-2 cells and NHOst cells. The present results indicate the expression of functional TSH receptors and D2 in human osteoblasts and suggest previously unrecognized roles of TSH receptors and local T(3) production by D2 in the pathophysiology of human osteoblasts.
- Published
- 2005
35. Cyclophilin C-associated protein and cyclophilin C mRNA are upregulated in penumbral neurons and microglia after focal cerebral ischemia
- Author
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Nobutaka Kawahara, Fumiaki Honda, Tatsuya Shimizu, Mitsunobu Nakamura, Nobuhito Saito, Shinichiro Tomizawa, Hideaki Imai, and Koji Seki
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Nerve Tissue Proteins ,In situ hybridization ,Brain Ischemia ,Rats, Sprague-Dawley ,Cyclophilins ,Cyclosporin a ,medicine ,Animals ,RNA, Messenger ,Cyclophilin ,In Situ Hybridization ,Glycoproteins ,Peptidylprolyl isomerase ,Neurons ,Extracellular Matrix Proteins ,biology ,Blotting, Northern ,Molecular biology ,Immunohistochemistry ,Cyclophilin C ,Rats ,Up-Regulation ,Neurology ,Cis-trans-Isomerases ,biology.protein ,Neurology (clinical) ,Microglia ,NeuN ,Cardiology and Cardiovascular Medicine ,Carrier Proteins ,Immunostaining - Abstract
Immunophilin ligands, such as cyclosporin A and FK506, have neuroprotective effects in experimental stroke models, although the precise mechanism is unclear. Cyclophilin C-associated protein (CyCAP) is a natural cellular ligand for the immunophilin, cyclophilin C, and has a protective effect against endotoxins by downmodulating the proinflammatory response. Expressions of CyCAP and cyclophilin C mRNA in a rat middle cerebral artery (MCA) occlusion ischemia model were investigated by Northern blotting and in situ hybridization. Both CyCAP and cyclophilin C mRNAs were ubiquitously distributed in the neurons of the normal brain. Expression increased in neurons of the periinfarct zone up to 7 days after MCA occlusion. The neuronal distribution was confirmed by counterimmunostaining of NeuN. Both mRNAs were predominantly expressed in microglia of the ischemic core at 7 days, confirmed by immunostaining with the microglial marker, ED1. The quantification of CyCAP and cyclophilin C mRNAs at 7 days by Northern blot analysis showed the 8.5-fold increase ( P
- Published
- 2005
36. Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease
- Author
-
Hidehiro Mizusawa, Kaoru Okuizumi, Osamu Onodera, Kazuhiko Ikeda, Akira Ueki, Shoji Tsuji, Hajime Tanaka, Yoshio Namba, Koji Seki, Shinichiro Nanko, Hitoshi Takahashi, Kiyomitsu Oyanagi, Ichiro Kanazawa, and Tokuo Yamamoto
- Subjects
Apolipoprotein E ,medicine.medical_specialty ,Very low-density lipoprotein ,Molecular Sequence Data ,VLDL receptor ,Biology ,Polymerase Chain Reaction ,Apolipoproteins E ,Japan ,Alzheimer Disease ,Reference Values ,Risk Factors ,Internal medicine ,Odds Ratio ,Genetics ,medicine ,Humans ,Allele ,Allele frequency ,Alleles ,DNA Primers ,Repetitive Sequences, Nucleic Acid ,Genetic association ,Cerebral Cortex ,Chromosomes, Human, Pair 14 ,Polymorphism, Genetic ,Base Sequence ,Odds ratio ,medicine.disease ,Endocrinology ,Receptors, LDL ,Regression Analysis ,Alzheimer's disease - Abstract
A specific isoform of apolipoprotein E has been associated with the accelerated rate of disease expression of sporadic Alzheimer's disease (AD) and late-onset familial AD (FAD). An earlier age at onset has also been demonstrated in familial AD patients with mutations in the amyloid precursor protein (APP) gene (APP717 and APP670/671)13 carrying the APOE epsilon-4 allele compared to those who do not, but not in familial AD patients with APP692 or 693 mutations, or in chromosome 14-linked familial AD patients. Hypothesizing that receptors for apoE-containing lipoproteins act as a potential risk factor for AD, we performed an association study using a polymorphic triplet (CGG) repeat in the gene for the VLDL receptor (VLDL-R), a receptor for apoE-containing lipoproteins. The frequency of the 5-repeat allele was significantly higher in all of the Japanese sporadic AD patients (P0.02) than in the Japanese controls. Moreover, the odds ratio was significantly increased in the AD patients homozygous for the 5-repeat allele (OR = 2.1, 95% CI = [1.1-4.2]). Multiple logistic regression analysis reveals that the relative risk conferred by the presence of two copies of the 5-repeat allele and at least one copy of the APOE epsilon-4 allele is 8.7 (95% CI = [2.9-25.8]). Our results suggest that the VLDL-R gene is a susceptibility gene for AD.
- Published
- 1995
37. [Study on blood rheology measured by MC-FAN]
- Author
-
Koji, Seki, Hiroyuki, Sumino, and Masami, Murakami
- Subjects
Adult ,Male ,Aging ,Body Weight ,Hemorheology ,Humans ,Female ,Lipids ,Body Mass Index - Abstract
We investigated the effects of various factors on blood rheology, which was evaluated by the passage time of heparinized whole blood using MC-FAN (Micro Channel array Flow ANalyzer). The time for 100 microliters of whole blood to pass through a microchannel array (Bloody 6-7) was determined. Each passage time was corrected by the saline passage time determined just before the measurement of sample blood. Our results suggest that blood rheology measured by MC-FAN is related to aging, body weight, body mass index and serum lipid parameters (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride). These results suggest that MC-FAN is useful to analyze blood rheology in pathophysiological conditions.
- Published
- 2003
38. Anemia in female patients with myasthenia gravis.
- Author
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Koji Sekiguchi, Kei Ishizuchi, Tsubasa Takizawa, Haruhiko Motegi, Munenori Oyama, Jin Nakahara, and Shigeaki Suzuki
- Subjects
Medicine ,Science - Abstract
Myasthenia gravis (MG) is the most common autoimmune neuromuscular disorder, and is more common in women than in men. Anemia is also more common in women. The purpose of this study was to investigate factors associated with anemia and the negative impact of anemia in female MG patients. We investigated factors related to MG and anemia in 215 female patients with MG, who were attending the MG clinic of Keio Hospital between January and December 2021. We statistically evaluated clinical factors related to anemia in patients with and without anemia. Eighty-five patients (40%) had anemia in the past, and 130 patients did not have anemia in the past. There were no significant differences in age at study, age at MG onset, body mass index, or frequency of autoantibodies between the anemia and non-anemia groups. MG severity evaluated by the MG Foundation of America classification was greater in the anemia group than in the non-anemia group. History of anemia was associated with immunosuppressive treatment, such as prednisolone and calcineurin inhibitor treatment. There was a correlation between hemoglobin levels and the MG-quality of life score. Long term immunosuppressive therapy can cause anemia in female MG patients. Anemia may negatively affect the quality of life of female MG patients.
- Published
- 2022
- Full Text
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39. Meningitis caused by Listeria monocytogenes in a locally advanced cervical cancer patient with pyometra: A case report
- Author
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Yusuke Matoba, Hiroshi Nishio, Koji Sekiguchi, Shunsuke Uno, Kenta Masuda, Makiko Hiramatsu, Mio Takahashi, Maki Oishi, Yoshifumi Uwamino, Sho Uchida, Yugaku Daté, Tohru Morisada, Kouji Banno, Jin Nakahara, and Daisuke Aoki
- Subjects
Cervical cancer ,Pyometra ,Listeria monocytogenes ,Concurrent chemoradiotherapy ,Meningitis ,Gynecology and obstetrics ,RG1-991 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Locally advanced cervical cancer occasionally induces pyometra, but there have been no reports of meningitis where pyometra is the cause of infection. Here, we report a case of Listeria monocytogenes meningitis related to pyometra during concurrent chemoradiotherapy (CCRT) in a cervical cancer patient. The patient, a 77-year-old woman, was diagnosed with Stage IIB (FIGO 2018) cervical adenocarcinoma, and CCRT was initiated. Pyometra was exacerbated during CCRT, and after her first brachytherapy, she presented at our hospital with fever and decreased consciousness level. After admission to the Intensive Care Unit, the patient lost consciousness and experienced frequent seizures; tracheal intubation was required. Whole-body computed tomography revealed pyometra; therefore, transvaginal removal of the abscess was performed. Laboratory tests and vital signs indicated septic shock, and meropenem was administered. L. monocytogenes was detected in the abscess from the uterine cavity and the blood cultures on the third day of hospitalization. A lumbar puncture was performed on the same day to investigate whether the patient had meningitis. A FilmArray meningitis/encephalitis panel test of the spinal fluid revealed L. monocytogenes. After the diagnosis of meningitis with L. monocytogenes, ampicillin and gentamicin were started, and the blood test results gradually improved. Five months after the initial episode, her consciousness recovered, however she still received mechanical ventilatory support. L. monocytogenes infections can occur in patients undergoing chemotherapy, even without the use of steroids or immunosuppressive agents. In cases with pyometra, intrauterine manipulation can increase the risk of severe infection.
- Published
- 2021
- Full Text
- View/download PDF
40. Spin-wave interconversion via thermoelectric point-contact control
- Author
-
Takuro Eguchi, Shoki Nezu, Yu Naemura, and Koji Sekiguchi
- Subjects
Physics ,QC1-999 - Abstract
The magnonic functionalities of magnonic devices, such as logic gates, majority gates, and multiplexers, critically depend on anisotropic spin-wave dispersions. Further, each magnonic function utilizes the advantages of distinct spin-wave modes. However, thus far, no method of directly combining magnonic functions to construct an integrated magnonic circuit has been proposed. Therefore, this paper presents a method for the interconversion of surface spin-waves and backward volume spin-waves using a thermoelectrically controlled magnetization gradient. The results of time- and frequency-domain spectroscopies, heat transfer analyses, and micromagnetic simulations demonstrate the effectiveness of the proposed method, through which spin-wave interconversion via thermoelectric control may be employed to develop integrated magnonic circuits.
- Published
- 2022
- Full Text
- View/download PDF
41. Overlap of Guillain-Barre syndrome and Bickerstaff's brainstem encephalitis
- Author
-
Nobuhiro Yuki, Mitsunori Yamada, Koji Seki, and Koichi Wakabayashi
- Subjects
Pediatrics ,medicine.medical_specialty ,Fatal outcome ,Polyradiculoneuropathy ,Autopsy ,digestive system ,Fatal Outcome ,Gangliosides ,medicine ,Humans ,reproductive and urinary physiology ,Aged ,Guillain-Barre syndrome ,business.industry ,bacterial infections and mycoses ,medicine.disease ,Neurology ,Immunoglobulin G ,Immunology ,bacteria ,Encephalitis ,Female ,Neurology (clinical) ,business ,Bickerstaff's brainstem encephalitis ,Brain Stem - Abstract
The nosological relationship between Bickerstaff s brainstem encephalitis (BBE) and Guillain-Barre syndrome (GBS) has yet to be clarified. We report results of the autopsy of a patient for whom overlapping BBE and GBS was diagnosed clinically. This and similar cases support the original authors' hypothesis that BBE is closely related to GBS.
- Published
- 1997
42. Lack of association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease
- Author
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Hajime Tanaka, Kaoru Okuizumi, Koji Seki, Ann M. Saunders, Shoji Tsuji, Yoshio Namba, Allen D. Roses, Osamu Onodera, Margaret A. Pericak-Vance, and Kazuhiko Ikeda
- Subjects
medicine.medical_specialty ,Cholesterol, VLDL ,Very Low-Density Lipoprotein Receptor ,Biology ,White People ,Degenerative disease ,Apolipoproteins E ,Japan ,Polymorphism (computer science) ,Alzheimer Disease ,Internal medicine ,medicine ,Humans ,Risk factor ,Allele ,Allele frequency ,Alleles ,Aged ,Polymorphism, Genetic ,medicine.disease ,United States ,Endocrinology ,Neurology ,lipids (amino acids, peptides, and proteins) ,Neurology (clinical) ,Gene polymorphism ,Alzheimer's disease - Abstract
To determine whether the association of the very low density lipoprotein receptor (VLDL-R) gene with Alzheimer's disease (AD), which has recently been identified in Japanese AD patients, is commonly observed in AD patients of other ethnic backgrounds, we have investigated the allele frequency of the polymorphic CGG repeat in the 5'-UTR of the VLDL-R gene using a data set of 84 Caucasian AD patients with 104 Caucasian controls. Although the allele frequency of the 8-repeat allele was slightly lower, and that of 9-repeat allele was slightly higher, in the Caucasian AD patients than in Caucasian controls, the differences were not statistically significant. Multiple logistic regression analysis using apolipoprotein E4 (APOE4) allele, 5, 8-, or 9-repeat allele of the VLDL-R gene, sex, and age at onset as the predictors revealed that only the APOE4 allele was significantly associated with AD in the data set of the Caucasian AD patients and controls.
- Published
- 1996
43. Cloning and nucleotide sequence of the inulin fructotransferase (DFA I-producing) gene of Arthrobacter globiformis S14-3
- Author
-
Takafumi Kasumi, Mamoru Kishimoto, Tadahiro Nagata, Koji Seki, Keiji Kainuma, Shoichi Kobayashi, and Kazutomo Haraguchi
- Subjects
Signal peptide ,DNA, Bacterial ,Magnetic Resonance Spectroscopy ,Molecular Sequence Data ,lac operon ,Molecular cloning ,Biology ,medicine.disease_cause ,Applied Microbiology and Biotechnology ,Biochemistry ,Polymerase Chain Reaction ,Analytical Chemistry ,chemistry.chemical_compound ,Bacterial Proteins ,medicine ,Escherichia coli ,Amino Acid Sequence ,Arthrobacter ,Cloning, Molecular ,Molecular Biology ,Peptide sequence ,Gene ,Base Sequence ,Organic Chemistry ,Nucleic acid sequence ,General Medicine ,Molecular biology ,chemistry ,Hexosyltransferases ,Genes, Bacterial ,DNA Probes ,DNA ,Biotechnology - Abstract
A gene encoding an inulin fructotransferase (DFA I-producing) [EC 2.4.1.200] from Arthrobacter globiformis S14-3 was cloned and the nucleotides sequenced, for the first time. The sequence indicated that the native enzyme protein is composed of 392 amino acid residues. The native enzyme is an extracellar enzyme produced in the culture supernatant of A. globiformis S14-3, but the nucleotide sequence of the gene lacks a sequence for signal peptide for secretion. The 1.5-kb DNA fragment encoding the gene was found to produce the active enzyme in the culture supernatant of an E. coli clone, under the control of the lac promoter of pUC119.
- Published
- 1995
44. Absence of linkage disequilibrium at amyloid precursor protein gene locus in Japanese familial Alzheimer's disease with 717Val--Ile mutation
- Author
-
Shoji Tsuji, John Hardy, Tetsuro Miki, Teruo Shimizu, Imaharu Nakano, Tadashi Miyatake, Osamu Onodera, Hisashi Kobayashi, Satoshi Naruse, Kouzin Kamino, Takeshi Kojima, Nobuyuki Nukina, Hajime Tanaka, Koji Seki, Yoshiyuki Sakaki, Asami Shibata, and Masaki Imagawa
- Subjects
Genetics ,Linkage disequilibrium ,Polymorphism, Genetic ,biology ,General Neuroscience ,Pedigree chart ,Locus (genetics) ,Valine ,medicine.disease ,Linkage Disequilibrium ,Amyloid beta-Protein Precursor ,Japan ,Alzheimer Disease ,Mutation ,medicine ,Amyloid precursor protein ,biology.protein ,Missense mutation ,Humans ,Alzheimer's disease ,Isoleucine ,Gene ,Alleles ,Founder effect - Abstract
To date, eleven independent FAD pedigrees with the 717 Val→Ile mutation have been identified. Interestingly, five pedigrees were of Japanese origin and four were of British origin. The apparent ethnic prediction of this mutation raises the possibility that there is a founder effect in these two island nations. We did not observe any significant linkage disequilibrium in any locus of APP and GT12 loci in the five Japanese FAD pedigrees with the 717 Val→Ile mutation. A founder effect would probably not be present in Japanese FAD pedgrees with the 717 Val→Ile mutation.
- Published
- 1993
45. New model of focal cerebral ischemia in the miniature pig
- Author
-
Tatsuya Shimizu, Hidekazu Hata, Yukitaka Tanaka, Kenjiro Konno, Nobuhito Saito, Mitsunobu Nakamura, Fumiaki Honda, Hideaki Imai, Koji Seki, Chisato Kubota, and Shinichiro Tomizawa
- Subjects
Pathology ,medicine.medical_specialty ,Miniature pig ,biology ,business.industry ,Ischemia ,biology.organism_classification ,medicine.disease ,Neurology ,Anesthesia ,Medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2005
46. Expression of cyclophilin C-associated protein and cyclophilin C mRNAs in focal cerebral ischemia
- Author
-
Nobutaka Kawahara, Nobuhito Saito, Mitsunobu Nakamura, Fumiaki Honda, Hideaki Imai, Shinichiro Tomizawa, Koji Seki, and Tatsuya Shimizu
- Subjects
Neurology ,Chemistry ,Ischemia ,medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,medicine.disease ,Molecular biology ,Cyclophilin C - Published
- 2005
47. ApoE–ε4 and early–onset Alzheimer's
- Author
-
Kaoru Okuizumi, Osamu Onodera, Hajime Tanaka, Hisashi Kobayashi, Shoji Tsuji, Hitoshi Takahashi, Kiyomitsu Oyanagi, Koji Seki, Masaharu Tanaka, Satoshi Naruse, Tadashi Miyatake, Hidehiro Mizusawa, and Ichiro Kanazawa
- Subjects
Text mining ,business.industry ,Genetics ,Biology ,Bioinformatics ,business ,Early onset - Published
- 1994
48. Subject Index Vol. 33, 1993
- Author
-
Bruno Domenici, Antonio Bertolotto, Yasuo Terao, Loredana Chiadò-Piat, Erik Van de Kelft, Jean-Jacques Martin, Alberto Galante, Luigi Murri, Charles Mahler, A. Prelle, Mauro Sihestrini, A. Baradello, Giorgio Bernardi, Tarniko Takemura, Tiziana Mongini, Zin-An Wu, Tetsuo Nemoto, Tadashi Miyatake, Takashi Inuzuka, Eva Braak, Maria Zina, Koji Seki, Patrick J. Willems, Tomio Kanda, G. Vita, Antonio Pietroiusti, Jürgen Bohl, Hannu Somer, Gloria Tognoni, Gabriele Siciliano, A. Bordoni, Heiko Braak, Paolo Stanzione, Manabu Sakuta, Myung Sik Lee, A. Toscano, Eric Van Marck, Mitsuru Kawai, Ritva K. Laaksonen, Bruno Rossi, Roger Abs, Kiyotoshi Kaneko, Il Saing Choi, N. Bresolin, Paul M. Parizel, Kong-Pin Lin, Kouichi Takeda, Rauno A. Tuikka, Shun-Jiun Wang, Johan Verheist, Ko-Pei Kao, C. Messina, Carlo Doriguzzi, Valentina Guerrini, Toshiki Uchihara, M. Clanet, Michele Maniscalco, Kazuyuki Ishida, Laura Palmucci, Ferdinando Sartucci, Ching-Piao Tsai, Kwong-Kum Liao, Jan Verlooy, Vinchi Wang, N. Checcarelli, and Silvana Bundino
- Subjects
Cognitive science ,Index (economics) ,Neurology ,Subject (documents) ,Neurology (clinical) ,Psychology ,Cognitive psychology - Published
- 1993
49. Genetic polymorphism of the Tau gene and neurodegenerative diseases with Tau pathology among Japanese
- Author
-
Kaoru Okuizumi, Koji Seki, Shoji Tsuji, Hiroki Takano, Yoji Onishi, and Yoh Horikawa
- Subjects
Genetics ,Tau pathology ,Neurology ,Neurology (clinical) ,Biology ,Gene - Published
- 1998
50. 598 Genetic risk factors for Alzheimer's disease
- Author
-
Hidehiro Mizusawa, S. Nanko, Koji Seki, Kaoru Okuizumi, T. Yamamoto, Shoji Tsuji, Akira Ueki, K. Oyanagi, H. Tanaka, Hitoshi Takahashi, Osamu Onodera, I. Kanazawa, Y. Namba, and Kenji Ikeda
- Subjects
Aging ,business.industry ,General Neuroscience ,Medicine ,Neurology (clinical) ,Disease ,Geriatrics and Gerontology ,Genetic risk ,Bioinformatics ,business ,Developmental Biology - Published
- 1996
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