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Circulating Autoantibody to Mature Neurons and Astrocytes of Humans and Some Mammals Present in a Demented Patient with Autoimmune Disorder
- Source :
- European Neurology. 33:450-453
- Publication Year :
- 1993
- Publisher :
- S. Karger AG, 1993.
-
Abstract
- Circulating autoantibody to a 48-kD nuclear protein in neurons and astrocytes of the human and bovine cerebrum were present in the serum of a demented patient with an autoimmune disorder. Other human visceral organs, dorsal root ganglion cells, neuroblastoma and glioblastoma cell lines, and rat cerebrum did not react with the patient's serum. No sera from age-matched controls, including those with Alzheimer's disease, reacted with the 48-kD protein. Only the mature neurons and astrocytes of humans and some mammals express the 48-kD protein. This antibody may be responsible for the patient's demented condition.
- Subjects :
- Male
Biology
Autoimmune Diseases
Diagnosis, Differential
Epitopes
Alzheimer Disease
medicine
Animals
Humans
Dementia
Nuclear protein
Aged
Autoantibodies
Neurons
Autoimmune disease
Cerebrum
Autoantibody
Brain
Nuclear Proteins
Middle Aged
medicine.disease
Magnetic Resonance Imaging
nervous system diseases
Cell nucleus
medicine.anatomical_structure
nervous system
Neurology
Astrocytes
Immunology
Cattle
Female
Neurology (clinical)
Neuron
Neuroscience
Astrocyte
Subjects
Details
- ISSN :
- 14219913 and 00143022
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- European Neurology
- Accession number :
- edsair.doi.dedup.....5fe52832ed98fc443eed8acf879602c4