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Your search keyword '"Koide, Fusataka"' showing total 22 results
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22 results on '"Koide, Fusataka"'

2. Immunogenicity and Efficacy of TNX-1800, A Live Virus Recombinant Poxvirus Vaccine Candidate, against SARS-CoV-2 Challenge in Nonhuman Primates

Author

Awasthi, Mayanka, primary, Macaluso, Anthony, additional, Myscofski, Dawn, additional, Prigge, Jon, additional, Koide, Fusataka, additional, Noyce, Ryan S., additional, Fogarty, Siobhan, additional, Stillwell, Helen, additional, Goebel, Scott J., additional, Daugherty, Bruce, additional, Nasar, Farooq, additional, Bavari, Sina, additional, and Lederman, Seth, additional

Published
2023
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12. Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: A synthetic route to anticancer vaccine candidates

Author

Ragupathi, Govind, Koide, Fusataka, Livingston, Philip O., Young Shin Cho, Atsushi Endo, Qian Wan, Spassova, Maria K., Keding, Stacy J., Allen, Jennifer, Ouerfelli, Ouathek, Wilson, Rebecca M., and Danishefsky, Samuel J.

Subjects
Antineoplastic antibiotics -- Chemical properties, Cancer -- Care and treatment, Polypeptides -- Chemical properties, Chemistry
Abstract

Several novel, fully synthetic, carbohydrate-based antitumor vaccines are assembled where each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue as one of the carbohydrate antigens.

Published
2006

18. Comparative Pathogenesis of Asian and African-Lineage Zika Virus in Indian Rhesus Macaque’s and Development of a Non-Human Primate Model Suitable for the Evaluation of New Drugs and Vaccines

Author

Rayner, Jonathan, primary, Kalkeri, Raj, additional, Goebel, Scott, additional, Cai, Zhaohui, additional, Green, Brian, additional, Lin, Shuling, additional, Snyder, Beth, additional, Hagelin, Kimberly, additional, Walters, Kevin, additional, and Koide, Fusataka, additional

Published
2018
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19. Comparative Pathogenesis of Asian and African-Lineage Zika Virus in Indian Rhesus Macaque’s and Development of a Non-Human Primate Model Suitable for the Evaluation of New Drugs and Vaccines

Author

Rayner, Jonathan O., primary, Kalkeri, Raj, additional, Goebel, Scott, additional, Cai, Zhaohui, additional, Green, Brian, additional, Lin, Shuling, additional, Snyder, Beth, additional, Hagelin, Kimberly, additional, Walters, Kevin B., additional, and Koide, Fusataka, additional

Published
2018
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22. The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates

Author

Tamara H. Cooper, Jillian Geiger, Kevin B. Walters, Fusataka Koide, Eri Nakayama, Raj Kalkeri, Paul Howley, John D. Hayball, Thomas E. Morrison, Liang Liu, Natalie A. Prow, Mary K. McCarthy, Kerrilyn R. Diener, Andreas Suhrbier, Preethi Eldi, Prow, Natalie A, Liu, Liang, McCarthy, Mary K, Walters, Kevin, Kalkeri, Raj, Geiger, Jillian, Koide, Fusataka, Cooper, Tamara H, Eldi, Preethi, Nakayama, Eri, Diener, Kerrilyn R, Howley, Paul M, Hayball, John D, Morrison, Thomas E, and Suhrbier, Andreas

Subjects
0301 basic medicine, lcsh:Immunologic diseases. Allergy, Sementis Copenhagen Vector (SCV), chikungunya virus (CHIKV), viruses, Immunology, medicine.disease_cause, Microbiology, lcsh:RC254-282, Virus, Article, Zika virus, Zika virus (ZIKV), 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immunity, medicine, Pharmacology (medical), 030212 general & internal medicine, Chikungunya, Vector (molecular biology), Pharmacology, biology, virus diseases, Vector vaccine, biology.organism_classification, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Virology, Vaccination, 030104 developmental biology, Infectious Diseases, chemistry, Vaccinia, lcsh:RC581-607, Biotechnology
Abstract

The Sementis Copenhagen Vector (SCV) is a new vaccinia virus-derived, multiplication-defective, vaccine technology assessed herein in non-human primates. Indian rhesus macaques (Macaca mulatta) were vaccinated with a multi-pathogen recombinant SCV vaccine encoding the structural polyproteins of both Zika virus (ZIKV) and chikungunya virus (CHIKV). After one vaccination, neutralising antibody responses to ZIKV and four strains of CHIKV, representative of distinct viral genotypes, were generated. A second vaccination resulted in significant boosting of neutralising antibody responses to ZIKV and CHIKV. Following challenge with ZIKV, SCV-ZIKA/CHIK-vaccinated animals showed significant reductions in viremias compared with animals that had received a control SCV vaccine. Two SCV vaccinations also generated neutralising and IgG ELISA antibody responses to vaccinia virus. These results demonstrate effective induction of immunity in non-human primates by a recombinant SCV vaccine and illustrates the utility of SCV as a multi-disease vaccine platform capable of delivering multiple large immunogens.

Published
2020

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