Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: A synthetic route to anticancer vaccine candidates

Several novel, fully synthetic, carbohydrate-based antitumor vaccines are assembled where each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue as one of the carbohydrate antigens.