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452 results on '"König, L."'

4. MR-guided adaptive versus ITV-based stereotactic body radiotherapy for hepatic metastases (MAESTRO): a randomized controlled phase II trial

Author

Hoegen, P., Zhang, K. S., Tonndorf-Martini, E., Weykamp, F., Regnery, S., Naumann, P., Lang, K., Ristau, J., Körber, S. A., Dreher, C., Buchele, C., Rippke, C., Renkamp, C. K., Paul, K. M., König, L., Büsch, C., Krisam, J., Sedlaczek, O., Schlemmer, H.-P., Niyazi, M., Corradini, S., Debus, J., Klüter, S., and Hörner-Rieber, J.

Published
2022
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8. Stereotactic Radiosurgery for 1-10 Brain Metastases Avoids Whole-Brain Radiotherapy - Results of the CYBER-SPACE Randomized Phase 2 Trial

Author

El Shafie, R., primary, Bernhardt, D., additional, Schiele, A., additional, Welzel, T., additional, Schmitt, D., additional, Thalmann, P., additional, Erdem, S., additional, Paul, A., additional, Hoene, S.J., additional, Lang, K., additional, König, L., additional, Weykamp, F., additional, Adeberg, S., additional, Lentz-Hommertgen, A., additional, Jaekel, C., additional, Bozorgmehr, F., additional, Thomas, M., additional, Kieser, M., additional, Debus, J., additional, and Rieken, S., additional

Published
2023
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9. Hypofractionated Stereotactic Radiotherapy (HFSRT) of the Resection Cavity vs. Whole-Brain Radiotherapy (WBRT) Following Brain Metastasis Resection – Results of the ESTRON Randomized Phase 2 Trial

Author

El Shafie, R., primary, Bernhardt, D., additional, Schiele, A., additional, Welzel, T., additional, Schmitt, D., additional, Thalmann, P., additional, Erdem, S., additional, Paul, A., additional, Hoene, S.J., additional, Lang, K., additional, König, L., additional, Weykamp, F., additional, Adeberg, S., additional, Lentz-Hommertgen, A., additional, Jaekel, C., additional, Bozorgmehr, F., additional, Thomas, M., additional, Kieser, M., additional, Debus, J., additional, and Rieken, S., additional

Published
2023
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10. Stereotactic Radiotherapy vs. Whole Brain Radiation Therapy for Patients with 1-10 Brain Metastases from Small Cell Lung Cancer: Results of the Randomized ENCEPHALON (ARO 2018-9) Trial

Author

Bernhardt, D., primary, El Shafie, R., additional, Thomas, M., additional, Bozorgmehr, F., additional, Schiele, A., additional, Schmitt, D., additional, Welzel, T., additional, Thalmann, P., additional, Paul, A., additional, König, L., additional, Lang, K., additional, Adeberg, S., additional, Höne, S., additional, Weykamp, F., additional, Vollmuth, P., additional, Lentz-Hommertgen, A., additional, Jaekel, C., additional, Nestle, U., additional, Kieser, M., additional, Debus, J., additional, and Rieken, S., additional

Published
2023
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11. Impact of inflammatory markers on survival in patients with limited disease small-cell lung cancer undergoing chemoradiotherapy

Author

Bernhardt D, Aufderstrasse S, König L, Adeberg S, Bozorgmehr F, Christopoulos P, El Shafie RA, Hörner-Rieber J, Kappes J, Thomas M, Herth F, Steins M, Debus J, and Rieken S

Subjects
small cell lung cancer, limited disease, comorbidity, NLR, LDH, CRP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Denise Bernhardt,1–3,* Sophie Aufderstrasse,1,2,* Laila König,1–3 Sebastian Adeberg,1–4 Farastuk Bozorgmehr,5,6 Petros Christopoulos,5,6 Rami A El Shafie,1,2 Juliane Hörner-Rieber,1–3 Jutta Kappes,6,7 Michael Thomas,5,6 Felix Herth,6,7 Martin Steins,5 Jürgen Debus,1–4 Stefan Rieken1–3 1Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany; 2Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; 3Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; 4Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 5Department of Thoracic Oncology, Thoraxklinik, Heidelberg University, Translational Lung Research Centre Heidelberg (TLRC-H), Heidelberg, Germany; 6German Centre for Lung Research (DZL), Heidelberg, Germany; 7Department of Pneumology, Thoraxklinik, Heidelberg University, Heidelberg, Germany *These authors contributed equally to this work Background: Systemic inflammation appears to play a role in the progression of numerous solid tumors by promoting tumor proliferation. Our current study aimed to evaluate the role of inflammatory markers in limited disease (LD) small-cell lung cancer (SCLC) patients undergoing thoracic chemoradiotherapy (TCR). Patients and methods: We retrospectively analyzed a total number of 350 SCLC patients diagnosed with LD SCLC who received TCR between 1999 and 2017 and had available blood tests within 2 weeks prior to the start of TCR. Serum C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH), hemoglobin (Hb) levels, and platelet count (Pc) were evaluated as potential inflammatory markers. Kaplan–Meier survival analysis was performed for overall survival (OS). For comparison of survival curves, the log-rank (­Mantel–Cox) test was used. Univariate and multivariate Cox proportional HRs were used to assess the influence of cofactors on OS. Results: Univariate analysis for OS revealed a statistically significant effect for LDH >400 U/L (HR 2.05 U/L; 95% CI 1.29–3.26 U/L; P=0.002), prophylactic cranial irradiation (PCI; HR 0.58; 95% CI 0.40–0.85; P=0.005), CRP >50 mg/L (HR 1.49 mg/L; 95% CI 1.05–2.10 mg/L; P=0.026), and Karnofsky performance scale (KPS) 70 years), Hb levels, and Pc did not influence survival. In multivariate analysis, OS was significantly affected by PCI (HR 0.64; 95% CI 0.43–0.94; P=0.026), LDH >400 U/L (HR 1.91 U/L; 95% CI 1.21–3.05 U/L; P=0.006), and CRP >50 mg/L (HR 1.43 mg/L; 95% CI 1.01–2.04 mg/L; P=0.045). KPS (≤70%) did not influence survival in multivariate analysis. Conclusion: Elevated CRP and LDH seem to be the independent prognostic factors for OS in LD SCLC patients undergoing TCR. However, elevated NLR was not found to be an independent prognostic factor for OS if taken prior to TCR. LDH and CRP are easily available blood tests and do not require additional resources for routine use and could be useful for clinical decision making. Keywords: small-cell lung cancer, limited disease, comorbidity, NLR, LDH, CRP

Published
2018

12. Bimodality treatment of patients with pelvic adenoid cystic carcinoma with photon intensity-modulated radiotherapy plus carbon ion boost: a case series

Author

Bernhardt D, Sterzing F, Adeberg S, Herfarth K, Katayama S, Foerster R, Hoerner-Rieber J, König L, Debus J, and Rieken S

Subjects
ACC of the Bartholin's gland, adenoid cystic carcinoma, ACC of the prostate, ion therapy, IMRT, tomotherapy, particle irradiation, carbon ion, case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Denise Bernhardt,1–3 Florian Sterzing,1–4,5 Sebastian Adeberg,1–4 Klaus Herfarth,1–3 Sonja Katayama,1,3 Robert Foerster,1,3,6 Juliane Hoerner-Rieber,1,3 Laila König,1,3 Juergen Debus,1–4 Stefan Rieken1,3 1Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany; 2Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; 3Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; 4Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 5Department of Radiation Oncology, Klinikum Kempten, Kempten, Germany; 6Department of Radiation Oncology, University Hospital of Zürich, Zürich, Switzerland Background: Treatment of patients with pelvic adenoid cystic carcinoma (ACC) remains a challenge owing to the rarity of the disease, the lack of data, and the relative radioresistance of these tumors.Case reports: This case series presents the results of three patients with recurrent or inoperable pelvic ACC treated with intensity-modulated radiotherapy (IMRT) plus carbon ion (C12) boost. Patients received C12 therapy at a dose of 3 Gray equivalents (GyE) (relative biological effectiveness [RBE]) per fraction up to 24 GyE RBE, followed by 50 GyE of photon IMRT in 25 fractions.Conclusion: IMRT plus C12 ion boost as a definitive or adjuvant treatment for pelvic ACCs seems to be a promising therapeutic option. No unexpected toxicity was detected and the observed toxicity remained consistently low. The initial treatment response is promising and similar to that experienced for head and neck ACCs. Keywords: ACC of Bartholin’s gland, adenoid cystic carcinoma, ACC of the prostate, ion therapy, IMRT, tomotherapy, particle irradiation, carbon ion

Published
2018

15. PO-1333 MR-guided radiotherapy ablates ultracentral lung tumors with favorable long-term outcomes

Author

Regnery, S., primary, Katsigiannopulos, E., additional, Hoegen, P., additional, Weykamp, F., additional, Sandrini, E., additional, Held, T., additional, Deng, M., additional, Eichkorn, T., additional, Buchele, C., additional, Rippke, C., additional, Renkamp, C.K., additional, König, L., additional, Lang, K., additional, Adeberg, S., additional, Klüter, S., additional, Debus, J., additional, and Hörner-Rieber, J., additional

Published
2023
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16. PO-1262 Non-inferior local control of IMRT-SIB compared to 3D-CRT-seqB - 5-year results of a phase III trial

Author

Forster, T., primary, Häfner, M.F., additional, Arians, N., additional, König, L., additional, Harrabi, S.B., additional, Schlampp, I., additional, Weykamp, F., additional, Meixner, E., additional, Lang, K., additional, Heinrich, V., additional, Weidner, N., additional, Hüsing, J., additional, Wallwiener, M., additional, Golatta, M., additional, Hennigs, A., additional, Heil, J., additional, Hof, H., additional, Krug, D., additional, Debus, J., additional, and Hörner-Rieber, J., additional

Published
2023
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17. MO-0054 Quality of life results of the APROVE trial after proton beam therapy for gynecological cancer

Author

Meixner, E., primary, Wark, A., additional, Forster, T., additional, Weykamp, F., additional, Lang, K., additional, König, L., additional, Lindel, K., additional, Oelmann-Avendano, J.T., additional, Krisam, J., additional, Schneeweiss, A., additional, Ellerbrock, M., additional, Mielke, T., additional, Hörner-Rieber, J., additional, Herfarth, K., additional, Debus, J., additional, and Arians, N., additional

Published
2023
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25. Teaching open and reproducible scholarship: A critical review of the evidence base for current pedagogical methods and their outcomes

Author

Pownall, M., Azevedo, F., König, L M., Slack, H. R., Evans, T. R., Flack, Z., Grinschgl, S., Elsherif, M., Gilligan-Lee, K. A., Oliveira, C. M. F. de, Gjoneska, B., Kalandadze, T., Button, K., Ashcroft-Jones, S., Terry, J., Albayrak-Aydemir, N., Děchtěrenko, F., Alzahawi, S., Arriaga, P., Sadhwani, S., and Framework for Open and Reproducible Research Training

Subjects
Ciências Sociais::Ciências da Educação [Domínio/Área Científica], Open scholarship, Pedagogy, Teaching, Higher education, Open research, Open science, Ciências Sociais::Psicologia [Domínio/Área Científica]
Abstract

In recent years, the scientific community has called for improvements in the credibility, robustness and reproducibility of research, characterized by increased interest and promotion of open and transparent research practices. While progress has been positive, there is a lack of consideration about how this approach can be embedded into undergraduate and postgraduate research training. Specifically, a critical overview of the literature which investigates how integrating open and reproducible science may influence student outcomes is needed. In this paper, we provide the first critical review of the literature surrounding the integration of open and reproducible scholarship into teaching and learning and its associated outcomes in students. Our review highlighted how embedding open and reproducible scholarship appears to be associated with (i) students’ scientific literacies (i.e. students’ understanding of open research, consumption of science, and the development of transferable skills); (ii) student engagement (i.e. motivation and engagement with learning, collaboration, and engagement in open research) and (iii) students’ attitudes towards science (i.e. trust in science and confidence in research findings). However, our review also identified a need for more robust and rigorous methods within pedagogical research, including more interventional and experimental evaluations of teaching practice. We discuss implications for teaching and learning scholarship. info:eu-repo/semantics/publishedVersion

Published
2023

27. User-Experience als zentraler Erfolgsfaktor für die digitale Vermittlung von Gesundheitswissen

Author

König, L and Hamer, TP

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund: Gesundheitskompetenz beschreibt die Fähigkeit einer Person, sich mit gesundheitsrelevanten Fragestellungen auseinanderzusetzen und Entscheidungen zu treffen, die dem Erhalt und der Förderung der eigenen Gesundheit dienen. Aus repräsentativen Erhebungen ist bekannt, dass die [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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32. The life cycle-dependent transcriptional profile of the obligate intracellular amoeba symbiont Amoebophilus asiaticus

Author

Selberherr, E, Penz, T, König, L, Conrady, B, Siegl, A, Horn, M, Schmitz-Esser, S, Selberherr, E, Penz, T, König, L, Conrady, B, Siegl, A, Horn, M, and Schmitz-Esser, S

Abstract

Free-living amoebae often harbor obligate intracellular bacterial symbionts. Amoebophilus (A.) asiaticus is a representative of a lineage of amoeba symbionts in the phylum Bacteroidota. Here, we analyse the transcriptome of A. asiaticus strain 5a2 at four time points during its infection cycle and replication within the Acanthamoeba host using RNA sequencing. Our results reveal a dynamic transcriptional landscape throughout different A. asiaticus life cycle stages. Many intracellular bacteria and pathogens utilize eukaryotic-like proteins (ELPs) for host cell interaction and the A. asiaticus 5a2 genome shows a particularly high abundance of ELPs. We show the expression of all genes encoding ELPs and found many ELPs to be differentially expressed. At the replicative stage of A. asiaticus, ankyrin repeat proteins and tetratricopeptide/Sel1-like repeat proteins were upregulated. At the later time points, high expression levels of a type 6 secretion system that likely prepares for a new infection cycle after lysing its host, were found. This study reveals comprehensive insights into the intracellular lifestyle of A. asiaticus and highlights candidate genes for host cell interaction. The results from this study have implications for other intracellular bacteria such as other amoeba-associated bacteria and the arthropod symbionts Cardinium forming the sister lineage of A. asiaticus.

Published
2022

33. Droogte en hitte: effecten op herkomsten van zomereik, Japanse lariks, hybride lariks en douglas

Author

Copini, P., Bouwman, M., König, L., Sass-Klaassen, U., Copini, P., Bouwman, M., König, L., and Sass-Klaassen, U.

Abstract

De extreme droogte en hitte van 2018 en 2019 hebben een groot effect gehad op de groei en de vitaliteit van veel boomsoorten. Pas in 2021 was in veel gebieden het watertekort voorbij. Hoe hebben bomen op de extreme jaren gereageerd? Zijn er verschillen in groeireacties tussen soorten, ook in vergelijking met eerdere droogtejaren? Het DendroLab van Wageningen University & Research (WUR) onderzoekt aan jaarringen hoe bomen in proefvelden van het Centrum voor Genetisch Bronnen Nederland (CGN) reageren.

Published
2022

34. Additional file 1 of MR-guided adaptive versus ITV-based stereotactic body radiotherapy for hepatic metastases (MAESTRO): a randomized controlled phase II trial

Author

Hoegen, P., Zhang, K. S., Tonndorf-Martini, E., Weykamp, F., Regnery, S., Naumann, P., Lang, K., Ristau, J., Körber, S. A., Dreher, C., Buchele, C., Rippke, C., Renkamp, C. K., Paul, K. M., König, L., Büsch, C., Krisam, J., Sedlaczek, O., Schlemmer, H.-P., Niyazi, M., Corradini, S., Debus, J., Klüter, S., and Hörner-Rieber, J.

Subjects
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Data_FILES
Abstract

Additional file 1. Study protocol.

Published
2022
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36. Gesundweiser.de – eine niedrigschwellige und frei verfügbare E-Learning-Plattform zur Steigerung der digitalen Gesundheitskompetenz

Author

König, L and Marbach-Breitrück, E

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund: Gesundheitskompetenz beschreibt die Fähigkeit einer Person, sich mit gesundheitsrelevanten Fragestellungen auseinanderzusetzen und Entscheidungen zu treffen, die dem Erhalt und der Förderung der eigenen Gesundheit dienen. Hierzu zählt auch die digitale Gesundheitskompetenz, [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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38. PO-1232 Magnetic resonance-guided stereotactic body radiotherapy of liver tumors: Initial clinical experience and patient-reported outcomes

Author

Weykamp, F., primary, Hoegen, P., additional, Klüter, S., additional, Renkamp, K., additional, König, L., additional, Seidensaal, K., additional, Regnery, S., additional, Liermann, J., additional, Rippke, C., additional, Koerber, S.A., additional, Buchele, C., additional, Debus, J., additional, and Hörner-Rieber, J., additional

Published
2021
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39. Effect of timing, technique and molecular features on brain control with local therapies in oncogene-driven lung cancer

Author

El Shafie, R.A., primary, Seidensaal, K., additional, Bozorgmehr, F., additional, Kazdal, D., additional, Eichkorn, T., additional, Elshiaty, M., additional, Weber, D., additional, Allgäuer, M., additional, König, L., additional, Lang, K., additional, Forster, T., additional, Arians, N., additional, Rieken, S., additional, Heussel, C.-P., additional, Herth, F.J., additional, Thomas, M., additional, Stenzinger, A., additional, Debus, J., additional, and Christopoulos, P., additional

Published
2021
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41. HIGH RATE OF METABOLIC COMPLETE RESPONSE AFTER LOW DOSE RADIOTHERAPY AND OBINUTUZUMAB IN EARLY STAGE FOLLICULAR LYMPHOMA: INITIAL RESULTS OF THE GAZAI STUDY (GLA 2018‐3).

Author

Herfarth, K., Scholz, C. W., Hübel, K., Wirths, S., Buske, C., Dürig, J., Forstpointner, R., Heidegger, S., Lenz, G., König, L., Meißner, J., Höller, U., Baues, C., De‐Colle, C., Wiegel, T., Gauler, T., Li, M., Combs, S. E., Eich, H., and Sander, A.

Subjects
FOLLICULAR lymphoma, IMMUNOGLOBULIN heavy chains
Abstract

The prospective, multicentric phase II GAZAI study of the German Lymphoma Alliance (GLA) investigated the efficacy of low dose radiation therapy (2 × 2 Gy) in combination with the anti-CD20 antibody Obinutuzumab in early stage nodal FL. At week 18, metabolic CR (Deauville score (DS) <3) was seen in 46/53 patients (87%; one patient only had a CT without FDG-PET). B Introduction: b The FORT trial demonstrated a higher complete remission (CR) rate using 12 × 2 Gy compared to 2 × 2 Gy in Follicular Lymphoma (FL) (67% vs. 47%). [Extracted from the article]

Published
2023
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44. PO-1652: In silico trial of cone-beam-CT guided adaptive planning for radiotherapy of locally advanced NSCLC

Author

Hoegen, P., primary, Lang, C., additional, Akbaba, S., additional, Häring, P., additional, Splinter, M., additional, Miltner, A., additional, Bachmann, M., additional, Stahl-Arnsberger, C., additional, Brechter, T., additional, Bernhardt, D., additional, Klüter, S., additional, Syed, M., additional, Weykamp, F., additional, König, L., additional, Debus, J., additional, and Hörner-Rieber, J., additional

Published
2020
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45. First 2-Year Results of the Multicenter, Randomized IMRT-MC2 Trial (MINT): Intensity-Modulated Radiotherapy with Simultaneous Integrated Boost versus 3-D-Conformal Radiotherapy with Consecutive Boost for Breast Cancer Patients

Author

Hörner-Rieber, J., primary, Forster, T., additional, Hommertgen, A., additional, Haefner, M.F., additional, Arians, N., additional, König, L., additional, Harrabi, S., additional, Schlampp, I., additional, Lossner, K., additional, Weykamp, F., additional, Heinrich, V., additional, Weidner, N., additional, Hüsing, J., additional, Heil, J., additional, Hof, H., additional, Krug, D., additional, and Debus, J., additional

Published
2020
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48. PO-1061: Stereotactic body radiotherapy for adrenal metastases of oligometastatic or oligoprogressive tumors

Author

König, L., primary, Häfner, M.F., additional, Katayama, S., additional, Koerber, S.A., additional, Tonndorf-Martini, E., additional, Bernhardt, D., additional, Von Nettelbladt, B., additional, Weykamp, F., additional, Hoegen, P., additional, Klüter, S., additional, Susko, M.S., additional, Debus, J., additional, and Hörner-Rieber, J., additional

Published
2020
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