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Applied techniques and some results of studies the higher nervous activity (HNA) of the people, their psychophysiological functions (PFF) by Ukrainian scientists and doctors were described, as well as influences of extreme conditions on HNA. Purpose. To show the results of the influence of extreme mountain conditions at high altitudes (hypoxia, etc.) demonstration and further research of changes in the psychophysiological functions of the brain under these conditions; description of the developed professional selection methods. Methods. Comparative analysis of a large number of the data from experiments and observations. Physical, mathematical, and program modeling. Methods of HNA, brain research: electroencephalography, diagnosis of personal neurodynamic features, etc. Three methods of PFF research: parameters of the neurodynamic level, parameters of the neuropsychological level, and personal specifics. The adapted questionnaire scheme (QS) based on Cattell's 16-factor personality tests was applied. Results. The influence of hypoxia and other factors of mountain conditions on HNA was studied deeply. The results were presented. Also, results of registered changes of EEG were presented in such extreme conditions. The influence of a number of stress factors in extreme conditions (hypoxia, etc.) has been demonstrated. Some basic methods of HNA research used in such conditions were described, and the results of investigations of individual typological features of the nervous systems were presented. Methods for studying human psychophysiological functions were described. Studies of human personal characteristics were described in detail. Data recorded by the PNN-3 device were taken for the diagnosis of personal neurodynamic features. The parameters of the neuropsychological level were determined using the following methods: "triangles" (the level of development of shortterm visual memory), "instrument scales" (working memory, attention functions, etc.), and "red and black tables" (allocation and switching of attention). Cattell estimated personality structures, features, and types of behavior of operators in stressful situations based on adapted QS. Mathematical models of the reliability of human nervous system functioning under extreme conditions were developed. Conclusions. The obtained results were taken as the basis for the developed professional selection methods for special contingents, pilots, operators, etc. Physical, mathematical, and program models of the reliability of the human nervous system functioning in these conditions were proposed. [ABSTRACT FROM AUTHOR]

The work was aimed to summarize the results describing the mechanisms of interaction of some aromatic hydrocarbons, isolated from Arthropodae, with biological membranes. Neurophysiological properties of the substances obtained from spider venoms, derivatives of phenol and indole with polyamine substituents, were studied by the method of transmembrane electrical currents registration in voltage clamp mode. Their influence was revealed as a result of chemo sensitive ionic currents characteristics changes due to the action of these substances on the membranes of rat hippocampal neurons. All of the studied substances were antagonists of glutamate channel-receptor complexes. Their blocking activity characteristics were examined as follows: caused reversible and irreversible blocking effects, the effects dependence on membrane holding potential, difference of their action on activated and inactivated receptors, kinetics of blocking actions, type of antagonism. Antagonists amphiphilic properties and the role of aromatic groups and polyamine substituents during interaction with the membranes were analyzed. The results of such analysis were accepted as a basis for development of physical model of artificial memory device. Principles of its work were explained as well. The results regarding the influence mechanisms of the studied substances on biological membranes were summarized. Some characteristics and functioning peculiarities of the suggested elements of storage devices were discussed. The properties of the proposed substances-analogues meet a number of requirements for the elements of such nano-devices.

The network organization of the systems of economic entities, which are distributed remotely over large territories, require the creation of high-quality communications for them. The purpose of present work was to demonstrate the possibility of using the latest means of communication based on Long-Term Evolution and Multiple-Input Multiple-Output technologies (LTE- and MIMO-technologies) in 3G and 4G networks to solve contemporary tasks of organizing of high-quality mobile communication in some places of the territory of Ukraine for the works that need biological and medical information in rarely settled, remote regions. The publication provides the author's data on the practical organization of communication in rural areas and considers the following issues. 1- Determination of spatial parameters of the LTE standard network. 2- Preparation of a map of the area. 3- Choosing an LTE network planning option. 4- Principles of construction and operation of LTE networks. 5- P-GW (Packet Data Network Gateway) functions. 6- MME (Mobility Management Entity) functions. 7- Functions of PCRF. MME (Mobility Management Entity) functions. 8- Functions of PCRF. 9- Peculiarities of using upper and lower frequencies for LTE. 10- Application of MIMO technology in LTE. 11- Application of MIMO technology in 3G and 4G networks. The results of the performed works can be applied for the networked structures development for the use in domestic economy, agriculture, for the science branches like biology, nature protection, and for information systems for such branches. In the result of the work done the type of antenna, other equipment were suggested; they should be used to strengthen 3G and 4G Long-Term Evolution communication in such conditions, as well as suitable 4G antenna for modem or router. Obtained results are suitable for providing of the work of information systems in agriculture, ecological monitoring, other areas of activities, based on biological and medical information; they all need quick data exchange as well as for scientific centers, other settlements, for which such communication possibilities primarily were developed. [ABSTRACT FROM AUTHOR]

The results of solving the problem of modeling the interaction of iron Fe3+ nanoparticles with thin bilayer membranes were represented. The purpose of the work was to create a physical model of the behavior and interaction of Fe3+ iron nanoparticles, which are located near thin films of organic substances. For this, physical model systems with thin films - BPM (bilayer phospholipid membranes) and BLM (bilayer lipid membranes) were considered and analyzed, and iron nanoparticles were introduced into these systems. To fulfill the given task, the data search methods ("data mining") obtained by the gas-liquid chromatography were used, as well as ones obtained in experiments with registration of transmembrane electric currents through artificial two-layer BPM and BLM membranes, and partially ones from the experiments on natural membranes with technique of voltage clamp. Since the applied FeCl3 undergoes hydrolysis, the formed hydroxyl groups interact with BLM membranes, also participating in the sum of interaction effects. Thus, it was concluded about the important role of hydroxyl groups in the mechanism of anionic selectivity of BLM, which is a confirmation of previously obtained research data. A number of effects with participation of ionophores, which increase the ion permeability of artificial BLM membranes, were also considered; they can bind metal ions due to iondipole interaction. The described system with a membrane and iron (III) ions located near it can be used to study a number of phenomena on both artificial and natural membranes, for example, when iron nanoparticles were absorbed by human body from the environment. For all considered cases, known physical and physico-chemical regularities and the corresponding developed mathematical apparatus were verified. Namely, analytical expressions based on electrostatic interactions of electric charges associated with Fe3+ ions and localized on membrane surfaces were valid for describing the considered effects. The considered model membranes are on the border between living and non-living nature. At the same time, these systems are simple systems to which the laws of physics and physical chemistry are applicable. And, in some cases, when developing some technical hybrid systems, they can play the role of biosensors. Due to their simplicity, such models can be reproduced quite easily in the conditions of experiments, substances testing with analytical purpose in extreme situations. Therefore, such simple, reliable, tested methods can be used in wartime situations with limited laboratory resources. [ABSTRACT FROM AUTHOR]

The aim of the work was to analyze the range of mathematical methods and to choose the most prospective ones from the point of view of application in biology and medicine. After analyzing of approximately 200 current publications, a list of respective methods was completed. This list includes both the most recent, intensively developed methods as well as traditionally used ones — mathematical statistics, stochastic methods, regression analysis, and others. From the first group the methods of cluster analysis, artificial neural networks and image processing were subdivided. A description of each of these methods and examples of their application in practice are given. A separate group is dedicated to complex modern works, in which the problems requiring the complex application of several methods are present. In conclusions a brief assessment of the methods of cluster analysis, artificial neural networks, image processing methods are given as well as recommendations for their practical application.

The influences of cosmic radiation on atoms and molecules in the Earth’s atmosphere were observed with subsequent transformation of atoms, molecules of gases, as well as development of states of oxygen deficiency (hypoxic) in biological organisms, some recommended ways of such disorders correction. Purposes of this work were to study radiation effects in ionosphere with subsequent high-energy transformations of atoms, molecules of gases at different heights above the Earth surface; interaction of some high-energy atmospheric particles with biological objects at near Earth’s heights up to 5.500 m above sea level, and oxygen roles in consequences of biological organisms’ irradiation. Methods. Analysis of results of satellite and rocket observations of the Earth atmosphere gases exploring at different altitudes above sea level. The investigations were done in mountain conditions at EMBS research station of the National Academy of Sciences of Ukraine. The comparative analysis of results of long-term observation of patients using standard laboratory methods, complex of methodological techniques such as clinical, physiological studies of respiratory, and cardiovascular systems. The research has been carried out concerning hematological, immunological states; functional state of higher nervous activity, mental and neurotic state; antihypoxants use, histochemical, biophysical methods, math modelling, others. Results. The data obtained during the satellites atmosphere exploring were presented: studies of influences on the structure of atoms, molecules in atmosphere, concentrations of gases from ionosphere to the Earth surface, such phenomena as photochemical processes, photoionization. The notion “information” was discussed basing on the phenomena, described in the article. Described studies of gases particles modification, oxygen deficiency in organisms (hypoxic states) were supplemented with the results of irradiated Chernobyl patients’ examinations, rehabilitation by Ukrainian doctors, scientists in mountain conditions. Conclusions. Phenomena of solar radiation influence on atoms, molecules and molecular complexes in the Earth’s atmosphere was observed. The main attention was concentrated on the studies of gases concentrations at different heights with linked effects of oxygen roles in consequences of organisms’ irradiation and rehabilitation. Practical recommendations for patients’ medical care and rehabilitation were done. [ABSTRACT FROM AUTHOR]

Currently in Ukraine, taking into account the development of the latest mobile Internet standards (3G/4G), it is possible to access the Internet even in remote places. There are no wired Internet due to the high cost of installation and maintenance. At the same time, a huge amount of equipment appeared on the market, which allows you to assemble systems for obtaining high-quality Internet over a wireless communication line. This refers to various types of antennas in the 900–2700MHz range, modems and routers with 3G/4G support. The locations of 3G/4G Internet base stations are in district centers predominantly. So, there is a situation that remote villages, settlements do not have the opportunity to get access to high-speed Internet. This especially harms the work of biological stations and rural medical clinics, which are spread over the territory of Ukraine and are often connected in a network. The purpose of the work is to describe briefly some practical results of our own development of providing high-quality mobile communication in some remote places of the territory of the state. To provide this service in remote areas of Ukraine, signal amplification is necessary. In addition, there is a problem with the propagation of radio waves over the rough terrains for the ultra short wave and microwave ranges. To solve this problem, it is proposed to use an external antenna with a high amplification factor, which will be installed at a height of at least 6 meters above the ground to reduce the impact of interference on the path of radio waves. [ABSTRACT FROM AUTHOR]

Radiation is an important and dangerous factor in contemporary reality in some regions of industrial countries, after technological accidents at nuclear objects, chemical enterprises, etc. This is also the reality of some contemporary military activities and armed conflicts. Radiation damages of organisms can arise also due to the natural reasons — aviation or space flights at high altitudes or even long stay on mountain heights. Natural reasons of such effects have been studied insufficiently for today. Purpose. To outline briefly some results of studies of the characteristics of ionizing radiation at different heights above the Earth. To describe briefly the influence of radiation factors on biological organisms and main mechanisms of these effects. To describe effects that cause pathological changes in organisms of people exposed to the low doses of radiation for a long time and methods of post-radiation rehabilitation of affected people in highlands conditions. Methods. Space satellite exploring of the Earth atmosphere at different altitudes above sea level with measurements of different characteristics of solar and galactic radiation (mainly X-ray, gamma radiation, as well as other types of ionizing radiation in some other ranges). Comparative analysis of the results of longterm observation of patients in hospital conditions using many standard laboratory methods of their states examinations. The conducted scientific research consisted of a complex of methodological techniques and approaches: clinical and physiological studies of respiratory and cardiovascular systems, hematological and immunological states, and functional state of higher nervous activity, mental and neurotic state; administration of antihypoxants, histochemical, biophysical and other methods were used to evaluate oxybiotic processes. Mathematical processing of the results, as well as methods of mathematical modeling were applied. Results. The results of the measurements of ionizing radiation levels during the satellite exploring of the Earth atmosphere at different altitudes were analyzed and presented in schemes. The mechanisms of damaging radiation effects in organisms at nano level were described: water radiolysis, “oxygen effect” as radio sensitizer, formation of various types of free radicals and peroxides with future consequences for organic compounds, cells, tissues, organs, and organisms. The results of medical treatment and rehabilitation at the EMBS of the persons irradiated by the low doses of radiation were presented, observed and discussed. Many of represented results were obtained thanks to the collective work of the great commands of our predecessors in science who searched for the possibilities of medical treatment and rehabilitation of patients who obtained low doses of radiation during long time. The contemporary results of possibilities of some developed pathological states pharmacological corrections were discussed; practical recommendations were done. Conclusions. Some of results of fulfilled works, which can be valuable in the treatment and rehabilitation of people of various contingents exposed to low doses of radiation of various natures for a long time, were presented. The outlined recommendations can be offered to persons of various radiation risk contingents for the purposes of their rehabilitation, in practice of health care, etc. [ABSTRACT FROM AUTHOR]

In contemporary world it is really necessary to provide long-term ecological monitoring of environment because of increasing tendency of chemical pollution either in industrial regions, or after the accidents or armed conflicts, etc. Chemical pollutants can be dispersed in cases of explosions, fires, other emergencies, as well as in cases of ruining of chemical enterprises, fires of gas and oil cycle enterprises, others. Some elements of information systems for environmental monitoring “EcoIS” and “CRC” were described briefly in this article as well as some details of their organization and principles of their functioning. In present article we continue detailed description of information system “EcoIS” structure and functioning, designed for the revealing, testing and identification of chemical substances – pollutants of environment. The purpose of present study was to design some functional units for networked “EcoIS” with distributed databases and describe them in details. [ABSTRACT FROM AUTHOR]

Investigations of the adaptation of living organisms to various extreme factors are important indeed. Aim. To characterize and analyze the results of research of structural and functional interdependencies of organisms in extreme conditions. Methods. Comparative analysis of the registered biochemical, physiological characteristics of the body, mathematical modelling of underlying mechanisms on their basis, information and computer technologies. Results. Deviations of organisms’ functions during adaptation processes caused changes in some structures of organism. Significant role of quantitative and qualitative changes of the erythrocyte formation system in the reliability of organisms functioning in extreme conditions in highlands was confirmed. The changes in red and white blood cells reflected largely the relationships between the organisms’ reactivity and resistance. The dependences on degree of rarefaction of the air, mode of climbing, effects of athlete’s training, etc. were revealed. Adaptive hemolysis of erythrocytes, when the biologically active substances were released from blood cells and acted as messengers, were shown to be the triggers capable to change cell metabolism; they played significant roles in reliability of organisms functioning. The set of program models was developed. Results were applied successfully for training of athletes for high-altitude climbing. Conclusions. Results of the studies on the structural and functional interdependencies of organisms in extreme conditions were reviewed and analyzed. Results of mathematical modeling coincided with the results obtained in experiments and observations. In the process of adaptation to hypoxia human organism behaved likes an ultra stable system. Obtained results can be applied in practice. [ABSTRACT FROM AUTHOR]

Copyright of Electronics & Control Systems is the property of National Aviation University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The main complications of organism damaged by SARS-CoV-2 virus are various cardiovascular system lesions. As a result, the secondary tissue hypoxia is developed and it is relevant to search the means for hypoxic state alleviation. Mathematical modeling of this process, followed by the imitation of hypoxic states development, and subsequent correction of hypoxia at this model may be one of the directions for investigations. Aim. The purpose of this study was to construct mathematical models of functional respiratory and blood circulatory systems to simulate the partial occlusion of blood vessels during viral infection lesions and pharmacological correction of resulting hypoxic state. Methods. Methods of mathematical modeling and dynamic programming were used. Transport and mass exchange of respiratory gases in organism, partial occlusion of blood vessels and influence of antihypoxant were described by the systems of ordinary nonlinear differential equations. Results. Mathematical model of functional respiratory system was developed to simulate pharmacological correction of hypoxic states caused by the complications in courses of viral infection lesions. The model was based on the theory of functional systems by P. K. Anokhin and the assumption about the main function of respiratory system. The interactions and interrelations of individual functional systems in organism were assumed. Constituent parts of our model were the models of transport and mass exchange of respiratory gases in organism, selforganization of respiratory and blood circulatory systems, partial occlusion of blood vessels and the transport of pharmacological substance. Conclusions. The series of computational experiments for averaged person organism demonstrated the possibility of tissue hypoxia compensation using pharmacological substance with vasodilating effect, and in the case of individual data array, it may be useful for the development of strategy and tactics for individual patient medical treatment. [ABSTRACT FROM AUTHOR]

Copyright of Electronics & Control Systems is the property of National Aviation University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of the work was to create a complex mathematical model simulating the course of the disease caused by the SARS-CoV-2 virus on the level of interaction between functional systems of organism and pharmacological correction of organism hypoxic states arising in the complicated course of the disease. In the present work the methods of mathematical modeling and theory of optimal control of moving objects were used. The proposed integrated mathematical model consisted on the mathematical models of functional systems of respiration and blood circulation, thermoregulation, immune response, erythropoesis, and pharmacological correction. Individual patient data were taken for this model, and the disturbing effect in the form of viral disease was simulated. The reactions of functional respiratory and blood circulatory systems were predicted. Partial pressures of respiratory gases in alveolar spaces and their tensions in lung capillaries blood, arterial and mixed venous blood, and tissue fluid were calculated. Further the intravenous injection of antihypoxant was simulated and the values of the same parameters were calculated. In such a way it was possible to choose the most optimal way of hypoxic state correction for any individual. This model is theoretical only for today because the models of respiratory and blood circulation systems were designed for the average person and it does not suppose peculiarities of individual persons infected with SARS-CoV-2. In particular, this concerns the pequliarities of gas exchange in the alveolar space and characteristics of respiratory gases diffusion through the alveolar-capillary and capillary-tissue membranes. However, it is one of possible directions for solving the complex tasks related to treatment of the disease caused by SARS-CoV-2 virus. In the result of the work the complex of information support for the imitation of viral disease course was developed at the level of interaction of organism functional systems, as well as pharmacological correction of caused by it hypoxic states. [ABSTRACT FROM AUTHOR]

The aim of the work was to develop electronic database of biological organisms (fishes, viruses) on the base of the methods that have been used before in mathematics, engineering, physics. The methods of object-oriented system analysis, construction of models of subject spaces (problem space, solution space), ER-diagrams, of constructing databases and others were applied. The examples of prototypes of modern databases with information about fishes developed over the past years in Western European and American countries were presented. An overview of applied methods, concepts and terminology from the areas of object-oriented system analysis, database designing was disclosed. In conclusions the description of constructed database and practical recommendations for the development of databases with the information about domestic biological organisms for electronic information systems are given. [ABSTRACT FROM AUTHOR]

The newest biotechnical systems for environment ecological monitoring based on the use of modern information and computer technologies and existing databases of chemical substances have been analyzed. In particular, there were observed such modern biophysical research methods as imitation and program modeling, based on the author results obtained in the experiments with registration of chemo-sensitive transmembrane electric currents in neurons in voltage clamp mode, use of neuronal fluorescent markers and accounting of organisms-bioindicators. The developed systems and methods allow revealing and identification of substances hazardous to living organisms and to make conclusions about their possible biological effects. The functioning of biotechnical information systems for environmental monitoring was analyzed in a wide time ranges, using modern databases, expert subsystems and interfaces capable to identify different types of chemicals. It is shown that for such systematic environmental monitoring it is possible to study and predict the effects of substances influences for a long time from the first moments of their exposure to individual cells of organism to months and years after exposure to the whole organism. [ABSTRACT FROM AUTHOR]

The purpose of the present work was to carry out a deep investigations of prototypes of information expert systems, their structure, functions and practical application, and to develop a new one for solving practical problems in biotechnology, laboratory practice and environmental protection. The observed prototypes were developed for the use in genetic studies, agricultural production, nature protection from pests and environmental pollutants, for works in medicine, and etc. During the work, following methods were used such as methods of comparative research of the samples of technical devices, imitation and program modeling, which were based on numerical results obtained in experiments with the recording of chemosensitive transmembrane electrical currents in neurons in voltage clamp mode. As a result, an original expert system was developed. It was coupled with a detector group, databases and interface. The developed expert system was able to distinguish automatically the certain types of chemicals at the input, to display their identification data and, if necessary, the reports about their harmfulness. Conclusions were done about the practical value of these data for the elaboration of new electronic expert systems for monitoring the presence of harmful substances in the environment. It was also discussed the possibility of developed expert system application for new methods of qualitative and quantitative analysis of some organic compounds. [ABSTRACT FROM AUTHOR]

The purpose of the work was to analyze existing information systems (IS) of biological objects and to propose the methods for development of such IS for insects on the example of Noctuidae (Lepidoptera). A detailed analysis of technical information concerning the distributed networked systems, access to computer systems to the common data in electronic IS and the organization of biomedical databases in the Internet was done. The peculiarities of IS’ prototypes development for environmental monitoring of the fauna have been discussed, in particular changes in the number of butterflies’ populations throughout France (including western and southern departments), the Noctuidae (Lepidoptera) in the steppe zone of Ukraine (Striltzivskyi Steppe), and the development of such IS for all territory of Ukraine. The results could be used to develop electronic IS for other biological organisms. [ABSTRACT FROM AUTHOR]

The purpose of the work was the examination of various databases construction as well as examination of possible errors. Peculiarities of biological objects which should be taken into account during databases design were analyzed. The methods for electronic collections with databases of biological organisms elaboration were studied. The appropriate algorithms for environmental conservation were analyzed and compared with some foreign analogs in order to study positive and negative experiences. The requirements for database with information about Noctuidae (Lepidoptera) and some Araneidae were formulated for the development of electronic information system “EcoIS”. The description of developed relational database with information about insects with analysis of selected object area were suggested taking into concideration the characteristics of biological objects and characteristics of information systems analogues. Conclusions concerning described new means with bioobjects databases and their application on the example of “EcoIS” system were done as well as some recommendations for the construction of databases with the information about living organisms basing on our experience. [ABSTRACT FROM AUTHOR]

The aim of the work was to generalize and analyze the use of electronic information systems in biotechnology in order to create new versions of these systems. The publications concerning the systems of different types for solving the problems in biotechnology were studied. Similar systems which traditionally belong to biology and medicine were classified. The prospects of their application for development of more advanced electronic systems were considered. [ABSTRACT FROM AUTHOR]

The purpose of present research was to analyze modern methods of processing biological images implemented before storage in databases for biotechnological purposes. The databases further were incorporated into web-based digital systems. Examples of such information systems were described in the work for two levels of biological material organization; databases for storing data of histological analysis and of whole brain were described. Methods of neuroimaging processing for electronic brain atlas were considered. It was shown that certain pathological features can be revealed in histological image processing. Several medical diagnostic techniques (for certain brain pathologies, etc.) as well as a few biotechnological methods are based on such effects. Algorithms of image processing were suggested. Electronic brain atlas was conveniently for professionals in different fields described in details. Approaches of brain atlas elaboration, “composite” scheme for large deformations as well as several methods of mathematic images processing were described as well. [ABSTRACT FROM AUTHOR]

The goal of publication was the analysis of cluster methods and possibility of their application in biotechnology. The evidences found in scientific literature were summarized and analyzed. This article gives a brief description of cluster analysis — basic principles, some examples of their application are given for biotechnological problems. Results of the biotechnological studies that required application of cluster methods in combination with other mathematical approaches are considered. The conclusion contains an evaluation of the performed analysis as well as recommendations on the application of cluster analysis methods in biotechnology. [ABSTRACT FROM AUTHOR]

The objective of this review was to analyze the results of electrophysiological studies of some biologically active chemicals in order to determine the regularities between their chemical structures and the effects that they ocure. It was proposed to use these regularities to improve the logical module of biotechnical expert system that works using module principle based on object-oriented and regression analysis. The data of electrophysiological studies of glutamatergic receptor antagonists: phenol- and indole-derivatives purified from the spiders' venoms of Arthropodae species were analyzed in this work. Some characteristics of receptor blocking by these toxins have been used to demonstrate empirical regularities between the chemical structures of antagonists and their electrophysiological effects. The possibility of practical use of such regularities for monitoring of harmful environmental pollutants - phenoland indole- derivatives as well as developing of new methods for their qualitative and quantitative analysis is discussed. [ABSTRACT FROM AUTHOR]

Copyright of Electronics & Control Systems is the property of National Aviation University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The purpose of the work was to analyze data about the construction of electronic automated work places for organization of more perfect ones for biotechnology. Methods of program and mathematic simulation, imitation modeling were used for these works. The information about some prototypes of electronic automated work places constructed for biology and linked sciences in Ukraine during the last 25-30 years was discussed. The results of some automated work places constructed by the authors were presented. In conclusion the observed experience was summarized and the set of recommendations for its practical implementation were done. [ABSTRACT FROM AUTHOR]

The purpose of present research is to demonstrate some trends of development of modeling methods for biotechnology according to contemporary achievements in science and technique. At the beginning the general approaches are outlined, some types of classifications of modeling methods are observed. The role of mathematic methods modeling for biotechnology in present epoque of information computer technologies intensive development is studied and appropriate scheme of interrelation of all these spheres is proposed. Further case studies are suggested: some mathematic models in three different spaces (1D, 2D, 3D models) are described for processes in living objects of different levels of hierarchic organization. In course of this the main attention was paid to some processes modeling in neurons as well as in their aggregates of different forms, including glioma cell masses (1D, 2D, 3D brain processes models). Starting from the models that have only theoretical importance for today, we describe at the end a model which application may be important for the practice. The work was done after the analysis of approximately 250 current publications in fields of biotechnology, including the authors' original works. [ABSTRACT FROM AUTHOR]