Search

Your search keyword '"Kluytmans-Van Den Bergh, Marjolein"' showing total 193 results
Start Over Author "Kluytmans-Van Den Bergh, Marjolein"
193 results on '"Kluytmans-Van Den Bergh, Marjolein"'

1. Cross-border differences in the prevalence and risk factors for carriage of antimicrobial resistance in children attending daycare centers: a point prevalence study in the Netherlands and Belgium

Author

Dequeker, Sara, van Hensbergen, Mitch, den Heijer, Casper D. J., Dhaeze, Wouter, Raven, Stijn F. H., Ewalts-Hakkoer, Helen, Tolsma, Paulien, Willemsen, Ina, van Drunen-Kamp, Karine J., van der Slikke-Verstraten, Krista, Goossens, Herman, Kluytmans-van den Bergh, Marjolein F. Q., and Hoebe, Christian J. P. A.

Published
2024
Full Text
View/download PDF

3. Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up

Author

Recanatini, Claudia, GeurtsvanKessel, Corine H., Pas, Suzan D., Broens, Els M., Maas, Martje, van Mansfeld, Rosa, Mutsaers-van Oudheusden, Anne J. G., van Rijen, Miranda, Schippers, Emile F., Stegeman, Arjan, Tami, Adriana, Veldkamp, Karin Ellen, Visser, Hannah, Voss, Andreas, Wegdam-Blans, Marjolijn C. A., Wertheim, Heiman F. L., Wever, Peter C., Koopmans, Marion P. G., Kluytmans, Jan A. J. W., and Kluytmans-van den Bergh, Marjolein F. Q.

Published
2023
Full Text
View/download PDF

4. Self-testing for the detection of SARS-CoV-2 infection with rapid antigen tests for people with suspected COVID-19 in the community

Author

Stohr, Joep J.J.M., Zwart, Vivian F., Goderski, Gabriel, Meijer, Adam, Nagel-Imming, Carla R.S., Kluytmans-van den Bergh, Marjolein F.Q., Pas, Suzan D., van den Oetelaar, Femke, Hellwich, Marloes, Gan, Kim H., Rietveld, Ariene, Verweij, Jaco J., Murk, Jean-Luc, van den Bijllaardt, Wouter, and Kluytmans, Jan A.J.W.

Published
2022
Full Text
View/download PDF

6. Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum β-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study

Author

Bonten, Marc, Bootsma, Martin, de Brauwer, Els, Bruijning-Verhagen, Patricia, Buiting, Anton, Diederen, Bram, van Elzakker, Erika, Friedrich, Alexander, Hopman, Joost, Kampinga, Greetje, van Keulen, Peter, Kluytmans, Jan, Kluytmans-van den Bergh, Marjolein, al Naiemi, Nashwan, Oudhuis, Guy, Raangs, Erwin, Rosema, Sigrid, Rossen, John, Ruijs, Gijs, Savelkoul, Paul, Troelstra, Annet, Vandenbroucke-Grauls, Christina, Verduin, Kees, Verhulst, Carlo, Vos, Margreet, Voss, Andreas, Willems, Rob, Willemsen, Ina, Kluytmans-van den Bergh, Marjolein F Q, Bruijning-Verhagen, Patricia C J, Vandenbroucke-Grauls, Christina M J E, de Brauwer, Els I G B, Buiting, Anton G M, Diederen, Bram M, van Elzakker, Erika P M, Friedrich, Alex W, Rossen, John W A, Ruijs, Gijs J H M, Savelkoul, Paul H M, Vos, Margreet C, Bonten, Marc J M, and Kluytmans, Jan A J W

Published
2019
Full Text
View/download PDF

7. Cross-border differences in the prevalence and risk factors for carriage of antimicrobial resistance in children attending daycare centers: a point prevalence study in the Netherlands and Belgium

Author

Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Dequeker, Sara, van Hensbergen, Mitch, den Heijer, Casper D.J., Dhaeze, Wouter, Raven, Stijn F.H., Ewalts-Hakkoer, Helen, Tolsma, Paulien, Willemsen, Ina, van Drunen-Kamp, Karine J., van der Slikke-Verstraten, Krista, Goossens, Herman, Kluytmans-van den Bergh, Marjolein F.Q., Hoebe, Christian J.P.A., on behalf of the i-4-1-Health Study Group, Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Dequeker, Sara, van Hensbergen, Mitch, den Heijer, Casper D.J., Dhaeze, Wouter, Raven, Stijn F.H., Ewalts-Hakkoer, Helen, Tolsma, Paulien, Willemsen, Ina, van Drunen-Kamp, Karine J., van der Slikke-Verstraten, Krista, Goossens, Herman, Kluytmans-van den Bergh, Marjolein F.Q., Hoebe, Christian J.P.A., and on behalf of the i-4-1-Health Study Group

Published
2024

8. Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium

Author

UMC Utrecht Holding, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Medische Microbiologie, MMB, Ecraid, van Kleef-van Koeveringe, Stefanie, Matheeussen, Veerle, Schuermans, Annette, De Koster, Sien, Perales Selva, Natascha, Jansens, Hilde, De Coninck, Dieter, De Bruyne, Katrien, Mensaert, Klaas, Kluytmans-van den Bergh, Marjolein, Kluytmans, Jan, Goossens, Herman, Dhaeze, Wouter, Leroux-Roels, Isabel, UMC Utrecht Holding, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Medische Microbiologie, MMB, Ecraid, van Kleef-van Koeveringe, Stefanie, Matheeussen, Veerle, Schuermans, Annette, De Koster, Sien, Perales Selva, Natascha, Jansens, Hilde, De Coninck, Dieter, De Bruyne, Katrien, Mensaert, Klaas, Kluytmans-van den Bergh, Marjolein, Kluytmans, Jan, Goossens, Herman, Dhaeze, Wouter, and Leroux-Roels, Isabel

Published
2024

10. COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study

Author

Sikkema, Reina S, Pas, Suzan D, Nieuwenhuijse, David F, O'Toole, Áine, Verweij, Jaco, van der Linden, Anne, Chestakova, Irina, Schapendonk, Claudia, Pronk, Mark, Lexmond, Pascal, Bestebroer, Theo, Overmars, Ronald J, van Nieuwkoop, Stefan, van den Bijllaardt, Wouter, Bentvelsen, Robbert G, van Rijen, Miranda M L, Buiting, Anton G M, van Oudheusden, Anne J G, Diederen, Bram M, Bergmans, Anneke M C, van der Eijk, Annemiek, Molenkamp, Richard, Rambaut, Andrew, Timen, Aura, Kluytmans, Jan A J W, Oude Munnink, Bas B, Kluytmans van den Bergh, Marjolein F Q, and Koopmans, Marion P G

Published
2020
Full Text
View/download PDF

11. Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave:a multicentre cross-sectional study with prospective follow-up

Author

Recanatini, Claudia, GeurtsvanKessel, Corine, Pas, Suzan, Broens, Els, Maas, Martje, van Mansfeld, Rosa, Mutsaers-van Oudheusden, Anne J.G., van Rijen, Miranda, Schippers, Emile, Stegeman, Arjan, Tami, Adriana, Veldkamp, Karin Ellen, Visser, Hannah, Voss, Andreas, Wegdam-Blans, Marjolijn, Wertheim, Heiman F.L., Wever, Peter, Koopmans, Marion, Kluytmans, Jan A.J.W., Kluytmans-van den Bergh, Marjolein F.Q., Bergmans, Anneke, van den Bijllaardt, Wouter, Buiting, Anton, Dohmen, Wietske, Friedrich, Alexander, van der Gun, Bernardina, Heederik, Dick, de Jong, Menno, Kluytmans, Jan, Kluytmans-van den Bergh, Marjolein, Meijer, Angelique, Murk, Jean Luc, Nabuurs, Marrigje, Niesters, Bert, ten Oever, Jaap, Mutsaers-van Oudheusden, Anne, Schweitzer, Valentijn, Streefkerk, Roel, Veloo, Alida, de Vries, Jutte, Wold, Karin, Wunderink, Herman, Recanatini, Claudia, GeurtsvanKessel, Corine, Pas, Suzan, Broens, Els, Maas, Martje, van Mansfeld, Rosa, Mutsaers-van Oudheusden, Anne J.G., van Rijen, Miranda, Schippers, Emile, Stegeman, Arjan, Tami, Adriana, Veldkamp, Karin Ellen, Visser, Hannah, Voss, Andreas, Wegdam-Blans, Marjolijn, Wertheim, Heiman F.L., Wever, Peter, Koopmans, Marion, Kluytmans, Jan A.J.W., Kluytmans-van den Bergh, Marjolein F.Q., Bergmans, Anneke, van den Bijllaardt, Wouter, Buiting, Anton, Dohmen, Wietske, Friedrich, Alexander, van der Gun, Bernardina, Heederik, Dick, de Jong, Menno, Kluytmans, Jan, Kluytmans-van den Bergh, Marjolein, Meijer, Angelique, Murk, Jean Luc, Nabuurs, Marrigje, Niesters, Bert, ten Oever, Jaap, Mutsaers-van Oudheusden, Anne, Schweitzer, Valentijn, Streefkerk, Roel, Veloo, Alida, de Vries, Jutte, Wold, Karin, and Wunderink, Herman

Abstract

Background: We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and describe its determinants and associated symptoms among unvaccinated healthcare workers (HCWs) after the first wave of the pandemic. Methods: HCWs from 13 Dutch hospitals were screened for antibodies against the spike protein of SARS-CoV-2 in June-July 2020 and after three months. Participants completed a retrospective questionnaire on determinants for occupational and community exposure to SARS-CoV-2 and symptoms suggestive of COVID-19 experienced since January 2020. The seroprevalence was calculated per baseline characteristic and symptom at baseline and after follow-up. Adjusted odds ratios (aOR) for seropositivity were determined using logistic regression. Results: Among 2328 HCWs, 323 (13.9%) were seropositive at enrolment, 49 of whom (15%) reported no previous symptoms suggestive of COVID-19. During follow-up, only 1% of the tested participants seroconverted. Seroprevalence was higher in younger HCWs compared to the mid-age category (aOR 1.53, 95% CI 1.07–2.18). Nurses (aOR 2.21, 95% CI 1.34–3.64) and administrative staff (aOR 1.87, 95% CI 1.02–3.43) had a higher seroprevalence than physicians. The highest seroprevalence was observed in HCWs in the emergency department (ED) (aOR 1.79, 95% CI 1.10–2.91), the lowest in HCWs in the intensive, high, or medium care units (aOR 0.47, 95% CI 0.31–0.71). Chronic respiratory disease, smoking, and having a dog were independently associated with a lower seroprevalence, while HCWs with diabetes mellitus had a higher seroprevalence. In a multivariable model containing all self-reported symptoms since January 2020, altered smell and taste, fever, general malaise/fatigue, and muscle aches were positively associated with developing antibodies, while sore throat and chills were negatively associated. 'Conclusions: The SARS-CoV-2 serop

Published
2023

13. Epidemiology and molecular typing of multidrug-resistant bacteria in daycare centers in Flanders, Belgium

Author

van Kleef - van Koeveringe, Stefanie, primary, Matheeussen, Veerle, additional, Jansens, Hilde, additional, Perales Selva, Natascha, additional, De Coninck, Dieter, additional, De Bruyne, Katrien, additional, Mensaert, Klaas, additional, Kluytmans-van den Bergh, Marjolein, additional, Kluytmans, Jan, additional, Goossens, Herman, additional, and Dhaeze, Wouter, additional

Published
2023
Full Text
View/download PDF

14. Prevention of severe infectious complications after colorectal surgery using oral non-absorbable antimicrobial prophylaxis: results of a multicenter randomized placebo-controlled clinical trial

Author

Mulder, Tessa, Kluytmans-van den Bergh, Marjolein, Vlaminckx, Bart, Roos, Daphne, de Smet, Anne Marie, de Vos tot Nederveen Cappel, Robert, Verheijen, Paul, Brandt, Alexandra, Smits, Anke, van der Vorm, Eric, Bathoorn, Erik, van Etten, Boudewijn, Veenemans, Jacobien, Weersink, Annemarie, Vos, Margreet, van ’t Veer, Nils, Nikolakopoulos, Stavros, Bonten, Marc, and Kluytmans, Jan

Published
2020
Full Text
View/download PDF

16. One Health surveillance of colistin-resistant Enterobacterales in Belgium and the Netherlands between 2017 and 2019.

Author

De Koster, Sien, Xavier, Basil Britto, Lammens, Christine, Perales Selva, Natascha, van Kleef-van Koeveringe, Stefanie, Coenen, Samuel, Glupczynski, Youri, Leroux-Roels, Isabel, Dhaeze, Wouter, Hoebe, Christian J. P. A., Dewulf, Jeroen, Stegeman, Arjan, Kluytmans-Van den Bergh, Marjolein, Kluytmans, Jan, and Goossens, Herman

Subjects
GRAM-negative bacterial diseases, ESCHERICHIA coli, SWINE farms, LONG-term care facilities, LIVESTOCK farms, HEALTH policy, FOSFOMYCIN
Abstract

Background: Colistin serves as the last line of defense against multidrug resistant Gram-negative bacterial infections in both human and veterinary medicine. This study aimed to investigate the occurrence and spread of colistin-resistant Enterobacterales (ColR-E) using a One Health approach in Belgium and in the Netherlands. Methods: In a transnational research project, a total of 998 hospitalized patients, 1430 long-term care facility (LTCF) residents, 947 children attending day care centres, 1597 pigs and 1691 broilers were sampled for the presence of ColR-E in 2017 and 2018, followed by a second round twelve months later for hospitalized patients and animals. Colistin treatment incidence in livestock farms was used to determine the association between colistin use and resistance. Selective cultures and colistin minimum inhibitory concentrations (MIC) were employed to identify ColR-E. A combination of short-read and long-read sequencing was utilized to investigate the molecular characteristics of 562 colistin-resistant isolates. Core genome multi-locus sequence typing (cgMLST) was applied to examine potential transmission events. Results: The presence of ColR-E was observed in all One Health sectors. In Dutch hospitalized patients, ColR-E proportions (11.3 and 11.8% in both measurements) were higher than in Belgian patients (4.4 and 7.9% in both measurements), while the occurrence of ColR-E in Belgian LTCF residents (10.2%) and children in day care centres (17.6%) was higher than in their Dutch counterparts (5.6% and 12.8%, respectively). Colistin use in pig farms was associated with the occurrence of colistin resistance. The percentage of pigs carrying ColR-E was 21.8 and 23.3% in Belgium and 14.6% and 8.9% in the Netherlands during both measurements. The proportion of broilers carrying ColR-E in the Netherlands (5.3 and 1.5%) was higher compared to Belgium (1.5 and 0.7%) in both measurements. mcr-harboring E. coli were detected in 17.4% (31/178) of the screened pigs from 7 Belgian pig farms. Concurrently, four human-related Enterobacter spp. isolates harbored mcr-9.1 and mcr-10 genes. The majority of colistin-resistant isolates (419/473, 88.6% E. coli; 126/166, 75.9% Klebsiella spp.; 50/75, 66.7% Enterobacter spp.) were susceptible to the critically important antibiotics (extended-spectrum cephalosporins, fluoroquinolones, carbapenems and aminoglycosides). Chromosomal colistin resistance mutations have been identified in globally prevalent high-risk clonal lineages, including E. coli ST131 (n = 17) and ST1193 (n = 4). Clonally related isolates were detected in different patients, healthy individuals and livestock animals of the same site suggesting local transmission. Clonal clustering of E. coli ST10 and K. pneumoniae ST45 was identified in different sites from both countries suggesting that these clones have the potential to spread colistin resistance through the human population or were acquired by exposure to a common (food) source. In pig farms, the continuous circulation of related isolates was observed over time. Inter-host transmission between humans and livestock animals was not detected. Conclusions: The findings of this study contribute to a broader understanding of ColR-E prevalence and the possible pathways of transmission, offering insights valuable to both academic research and public health policy development. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Detection of SARS-CoV-2 in Air and on Surfaces in Rooms of Infected Nursing Home Residents

Author

IRAS OH Epidemiology Microbial Agents, Faculteit Diergeneeskunde, Linde, Kimberly J, Wouters, Inge M, Kluytmans, Jan A J W, Kluytmans-van den Bergh, Marjolein F Q, Pas, Suzan D, Koopmans, Marion P G, GeurtsvanKessel, Corine H, Meier, Melanie, Meijer, Patrick, Raben, Ceder R, Spithoven, Jack, Tersteeg-Zijderveld, Monique H G, COCON Consortium, Heederik, Dick J J, Dohmen, Wietske, IRAS OH Epidemiology Microbial Agents, Faculteit Diergeneeskunde, Linde, Kimberly J, Wouters, Inge M, Kluytmans, Jan A J W, Kluytmans-van den Bergh, Marjolein F Q, Pas, Suzan D, Koopmans, Marion P G, GeurtsvanKessel, Corine H, Meier, Melanie, Meijer, Patrick, Raben, Ceder R, Spithoven, Jack, Tersteeg-Zijderveld, Monique H G, COCON Consortium, Heederik, Dick J J, and Dohmen, Wietske

Published
2023

18. Epidemiology and molecular typing of multidrug-resistant bacteria in day care centres in Flanders, Belgium

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, Medische Microbiologie, Van Kleef-Van Koeveringe, Stefanie, Matheeussen, Veerle, Jansens, Hilde, Perales Selva, Natascha, De Coninck, Dieter, De Bruyne, Katrien, Mensaert, Klaas, Kluytmans-Van Den Bergh, Marjolein, Kluytmans, Jan, Goossens, Herman, Dhaeze, Wouter, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, Medische Microbiologie, Van Kleef-Van Koeveringe, Stefanie, Matheeussen, Veerle, Jansens, Hilde, Perales Selva, Natascha, De Coninck, Dieter, De Bruyne, Katrien, Mensaert, Klaas, Kluytmans-Van Den Bergh, Marjolein, Kluytmans, Jan, Goossens, Herman, and Dhaeze, Wouter

Published
2023

19. Detection of SARS-CoV-2 in Air and on Surfaces in Rooms of Infected Nursing Home Residents

Author

Linde, Kimberly J, Wouters, Inge M, Kluytmans, Jan A J W, Kluytmans-van den Bergh, Marjolein F Q, Pas, Suzan D, Koopmans, Marion P G, GeurtsvanKessel, Corine H, Meier, Melanie, Meijer, Patrick, Raben, Ceder R, Spithoven, Jack, Tersteeg-Zijderveld, Monique H G, Heederik, Dick J J, Dohmen, Wietske, IRAS OH Epidemiology Microbial Agents, Faculteit Diergeneeskunde, and Virology

Subjects
nursing home, SARS-CoV-2, SDG 3 - Good Health and Well-being, Public Health, Environmental and Occupational Health, surface, air levels
Abstract

There is an ongoing debate on airborne transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a risk factor for infection. In this study, the level of SARS-CoV-2 in air and on surfaces of SARS-CoV-2 infected nursing home residents was assessed to gain insight in potential transmission routes. During outbreaks, air samples were collected using three different active and one passive air sampling technique in rooms of infected patients. Oropharyngeal swabs (OPS) of the residents and dry surface swabs were collected. Additionally, longitudinal passive air samples were collected during a period of 4 months in common areas of the wards. Presence of SARS-CoV-2 RNA was determined using RT-qPCR, targeting the RdRp- and E-genes. OPS, samples of two active air samplers and surface swabs with Ct-value ≤35 were tested for the presence of infectious virus by cell culture. In total, 360 air and 319 surface samples from patient rooms and common areas were collected. In rooms of 10 residents with detected SARS-CoV-2 RNA in OPS, SARS-CoV-2 RNA was detected in 93 of 184 collected environmental samples (50.5%) (lowest Ct 29.5), substantially more than in the rooms of residents with negative OPS on the day of environmental sampling (n = 2) (3.6%). SARS-CoV-2 RNA was most frequently present in the larger particle size fractions [>4 μm 60% (6/10); 1–4 μm 50% (5/10)

Published
2023

20. Genetic characterization of ESBL-producing and ciprofloxacin-resistant Escherichia coli from Belgian broilers and pigs

Author

De Koster, Sien, Ringenier, Moniek, Xavier, Britto Basil, Lammens, Christine, De Coninck, Dieter, De Bruyne, Katrien, Mensaert, Klaas, Kluytmans-van den Bergh, Marjolein, Kluytmans, Jan, Dewulf, Jeroen, Goossens, Herman, and i-4-1-Health Study Group

Subjects
Microbiology (medical), EXPRESSION, TRANSMISSION, PUMP, DIVERSITY, PLASMIDS, Microbiology, livestock, ESBL, ciprofloxacin, Escherichia coli, SOXS, TOOL, Human medicine, Veterinary Sciences, MARA, Biology, FLUOROQUINOLONE RESISTANCE, WGS
Abstract

BackgroundThe increasing number of infections caused by Escherichia coli resistant to clinically important antibiotics is a global concern for human and animal health. High overall levels of extended-spectrum beta-lactamase (ESBL)-producing and ciprofloxacin-resistant (ciproR) Escherichia coli in livestock are reported in Belgium. This cross-sectional study aimed to genotypically characterize and trace ESBL-and ciproR-E. coli of Belgian food-producing animals. MethodsA total of 798 fecal samples were collected in a stratified-random sampling design from Belgian broilers and sows. Consequently, 77 ESBL-E. coli and 84 ciproR-E. coli were sequenced using Illumina MiSeq. Minimum inhibitory concentration (MIC) for fluoroquinolones and cephalosporins were determined. Molecular in silico typing, resistance and virulence gene determination, and plasmid identification was performed. Scaffolds harboring ESBL or plasmid-mediated quinolone resistance (PMQR) genes were analyzed to detect mobile genetic elements (MGEs) and plasmid origins. Core genome allelic distances were used to determine genetic relationships among isolates. ResultsA variety of E. coli sequence types (ST) (n = 63), resistance genes and virulence profiles was detected. ST10 was the most frequently encountered ST (8.1%, n = 13). The pandemic multidrug-resistant clone ST131 was not detected. Most farms harbored more than one ESBL type, with bla(CTX-M-1) (41.6% of ESBL-E. coli) being the most prevalent and bla(CTX M-15) (n = 3) being the least prevalent. PMQR genes (15.5%, n = 13) played a limited role in the occurrence of ciproR-E. coli. More importantly, sequential acquisition of mutations in quinolone resistance-determining regions (QRDR) of gyrA and parC led to increasing MICs for fluoroquinolones. GyrA S83L, D87N and ParC S80I mutations were strongly associated with high-level fluoroquinolone resistance. Genetically related isolates identified within the farms or among different farms highlight transmission of resistant E. coli or the presence of a common reservoir. IncI1-I(alpha) replicon type plasmids carried different ESBL genes (bla(CTX-M-1), bla(CTX-M-32) and bla(TEM-52C)). In addition, the detection of plasmid replicons with associated insertion sequence (IS) elements and ESBL/PMQR genes in different farms and among several STs (e.g., IncI1-I(alpha)/IncX3) underline that plasmid transmission could be another important contributor to transmission of resistance in these farms. ConclusionOur findings reveal a multifaceted narrative of transmission pathways. These findings could be relevant in understanding and battling the problem of antibiotic resistance in farms.

Published
2023

23. Extended-Spectrum β-Lactamase—Producing Escherichia coli From Retail Chicken Meat and Humans: Comparison of Strains, Plasmids, Resistance Genes, and Virulence Factors

Author

Kluytmans, Jan A. J. W., Overdeves, Ilse T. M. A., Willemsen, Ina, Kluytmans-van den Bergh, Marjolein F. Q., van der Zwaluw, Kim, Heck, Max, Rijnsburger, Martine, Vandenbroucke-Grauls, Christina M. J. E., Savelkoul, Paul H. M., Johnston, Brian D., Gordon, David, and Johnson, James R.

Published
2013
Full Text
View/download PDF

24. Self-testing for the detection of SARS-CoV-2 infection with rapid antigen tests for people with suspected COVID-19 in the community

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Medische Microbiologie, Stohr, Joep J.J.M., Zwart, Vivian F., Goderski, Gabriel, Meijer, Adam, Nagel-Imming, Carla R.S., Kluytmans-van den Bergh, Marjolein F.Q., Pas, Suzan D., van den Oetelaar, Femke, Hellwich, Marloes, Gan, Kim H., Rietveld, Ariene, Verweij, Jaco J., Murk, Jean Luc, van den Bijllaardt, Wouter, Kluytmans, Jan A.J.W., Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Medische Microbiologie, Stohr, Joep J.J.M., Zwart, Vivian F., Goderski, Gabriel, Meijer, Adam, Nagel-Imming, Carla R.S., Kluytmans-van den Bergh, Marjolein F.Q., Pas, Suzan D., van den Oetelaar, Femke, Hellwich, Marloes, Gan, Kim H., Rietveld, Ariene, Verweij, Jaco J., Murk, Jean Luc, van den Bijllaardt, Wouter, and Kluytmans, Jan A.J.W.

Published
2022

27. Distinguishing blaKPC gene-containing IncF plasmids from epidemiologically related and unrelated enterobacteriaceae based on short- And long-read sequence data

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Stohr, Joep J.J.M., Kluytmans-Van den Bergh, Marjolein F.Q., Weterings, Veronica A.T.C., Rossen, John W.A., Kluytmans, Jan A.J.W., Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Stohr, Joep J.J.M., Kluytmans-Van den Bergh, Marjolein F.Q., Weterings, Veronica A.T.C., Rossen, John W.A., and Kluytmans, Jan A.J.W.

Published
2021

29. Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands

Author

Oude Munnink, Bas B., Nieuwenhuijse, David F., Stein, Mart, O’Toole, Áine, Haverkate, Manon, Mollers, Madelief, Kamga, Sandra K., Schapendonk, Claudia, Pronk, Mark, Lexmond, Pascal, van der Linden, Anne, Bestebroer, Theo, Chestakova, Irina, Overmars, Ronald J., van Nieuwkoop, Stefan, Molenkamp, Richard, van der Eijk, Annemiek A., GeurtsvanKessel, Corine, Vennema, Harry, Meijer, Adam, Rambaut, Andrew, van Dissel, Jaap, Sikkema, Reina S., Timen, Aura, Koopmans, Marion, Oudehuis, G. J. A. P. M., Schinkel, Janke, Kluytmans, Jan, Kluytmans-van den Bergh, Marjolein, van den Bijllaardt, Wouter, Berntvelsen, Robbert G., van Rijen, Miranda M. L., Schneeberger, Peter, Pas, Suzan, Diederen, Bram M., Bergmans, Anneke M. C., van der Eijk, P. A. Verspui, Verweij, Jaco J., Buiting, Anton G. N., Streefkerk, Roel, Aldenkamp, A. P., de Man, P., Koelemal, J. G. M., Ong, D., Paltansing, S., Veassen, N., Sleven, Jacqueline, Bakker, Leendert, Brockhoff, Heinrich, Rietveld, Ariene, Slijkerman Megelink, Fred, Cohen Stuart, James, de Vries, Anne, van der Reijden, Wil, Ros, A., Lodder, Esther, Verspui-van der Eijk, Ellen, Huijskens, Inge, Kraan, E. M., van der Linden, M. P. M., Debast, S. B., Naiemi, N. Al, Kroes, A. C. M., Damen, Marjolein, Dinant, Sander, Lekkerkerk, Sybren, Pontesilli, Oscar, Smit, Pieter, van Tienen, Carla, Godschalk, P. C. R., van Pelt, Jorien, Ott, Alewijn, van der Weijden, Charlie, Wertheim, Heiman, Rahamat-Langendoen, Janette, Reimerink, Johan, Bodewes, Rogier, Duizer, Erwin, van der Veer, Bas, Reusken, Chantal, Lutgens, Suzanne, Hermans, Mirjam, Wever, P., Leenders, A., ter Waarbeek, Henriette, Hoebe, Christian, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Virology, RS: CAPHRI - R4 - Health Inequities and Societal Participation, and Med Microbiol, Infect Dis & Infect Prev

Subjects
0301 basic medicine, medicine.medical_specialty, Molecular biology, Clinical Decision-Making, Pneumonia, Viral, Genome, Viral, medicine.disease_cause, Disease cluster, General Biochemistry, Genetics and Molecular Biology, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Environmental health, Pandemic, Epidemiology, medicine, Humans, Author Correction, Pandemics, Netherlands, Coronavirus, Respiratory tract diseases, Whole Genome Sequencing, biology, SARS-CoV-2, Transmission (medicine), Public health, COVID-19, Outbreak, Genomics, General Medicine, biology.organism_classification, 3. Good health, 030104 developmental biology, Geography, ZIKA, 030220 oncology & carcinogenesis, VIRUS, Public Health, Coronavirus Infections
Abstract

In late December 2019, a cluster of cases of pneumonia of unknown etiology were reported linked to a market in Wuhan, China1. The causative agent was identified as the speciesSevere acute respiratory syndrome-related coronavirusand was named SARS-CoV-2 (ref. 2). By 16 April the virus had spread to 185 different countries, infected over 2,000,000 people and resulted in over 130,000 deaths3. In the Netherlands, the first case of SARS-CoV-2 was notified on 27 February. The outbreak started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, and later also outside, the south of the Netherlands. The combination of near to real-time whole-genome sequence analysis and epidemiology resulted in reliable assessments of the extent of SARS-CoV-2 transmission in the community, facilitating early decision-making to control local transmission of SARS-CoV-2 in the Netherlands. We demonstrate how these data were generated and analyzed, and how SARS-CoV-2 whole-genome sequencing, in combination with epidemiological data, was used to inform public health decision-making in the Netherlands. Metastava project.

Published
2020

30. COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study

Author

MMB Staf diagnostiek, MMB, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Sikkema, Reina S, Pas, Suzan D, Nieuwenhuijse, David F, O'Toole, Áine, Verweij, Jaco, van der Linden, Anne, Chestakova, Irina, Schapendonk, Claudia, Pronk, Mark, Lexmond, Pascal, Bestebroer, Theo, Overmars, Ronald J, van Nieuwkoop, Stefan, van den Bijllaardt, Wouter, Bentvelsen, Robbert G, van Rijen, Miranda M L, Buiting, Anton G M, van Oudheusden, Anne J G, Diederen, Bram M, Bergmans, Anneke M C, van der Eijk, Annemiek, Molenkamp, Richard, Rambaut, Andrew, Timen, Aura, Kluytmans, Jan A J W, Oude Munnink, Bas B, Kluytmans van den Bergh, Marjolein F Q, Koopmans, Marion P G, MMB Staf diagnostiek, MMB, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Sikkema, Reina S, Pas, Suzan D, Nieuwenhuijse, David F, O'Toole, Áine, Verweij, Jaco, van der Linden, Anne, Chestakova, Irina, Schapendonk, Claudia, Pronk, Mark, Lexmond, Pascal, Bestebroer, Theo, Overmars, Ronald J, van Nieuwkoop, Stefan, van den Bijllaardt, Wouter, Bentvelsen, Robbert G, van Rijen, Miranda M L, Buiting, Anton G M, van Oudheusden, Anne J G, Diederen, Bram M, Bergmans, Anneke M C, van der Eijk, Annemiek, Molenkamp, Richard, Rambaut, Andrew, Timen, Aura, Kluytmans, Jan A J W, Oude Munnink, Bas B, Kluytmans van den Bergh, Marjolein F Q, and Koopmans, Marion P G

Published
2020

31. Prevalence and Clinical Presentation of Health Care Workers With Symptoms of Coronavirus Disease 2019 in 2 Dutch Hospitals During an Early Phase of the Pandemic

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Staf diagnostiek, Kluytmans-van den Bergh, Marjolein F Q, Buiting, Anton G M, Pas, Suzan D, Bentvelsen, Robbert G, van den Bijllaardt, Wouter, van Oudheusden, Anne J G, van Rijen, Miranda M L, Verweij, Jaco J, Koopmans, Marion P G, Kluytmans, Jan A J W, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Staf diagnostiek, Kluytmans-van den Bergh, Marjolein F Q, Buiting, Anton G M, Pas, Suzan D, Bentvelsen, Robbert G, van den Bijllaardt, Wouter, van Oudheusden, Anne J G, van Rijen, Miranda M L, Verweij, Jaco J, Koopmans, Marion P G, and Kluytmans, Jan A J W

Published
2020

32. Clinical performance and sample freeze-thaw stability of the cobas (R) 6800 SARS-CoV-2 assay for the detection of SARS-CoV-2 in oro-/nasopharyngeal swabs and lower respiratory specimens

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Staf diagnostiek, Stohr, Joep J J M, Wennekes, Meike, van der Ent, Martijn, Diederen, Bram M W, Kluytmans-van den Bergh, Marjolein F Q, Bergmans, Anneke M C, Kluytmans, Jan A J W, Pas, Suzan D, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Staf diagnostiek, Stohr, Joep J J M, Wennekes, Meike, van der Ent, Martijn, Diederen, Bram M W, Kluytmans-van den Bergh, Marjolein F Q, Bergmans, Anneke M C, Kluytmans, Jan A J W, and Pas, Suzan D

Published
2020

33. Development of amoxicillin resistance in Escherichia coli after exposure to remnants of a non-related phagemid-containing E. coli: an exploratory study

Author

Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Stohr, Joep J J M, Kluytmans-van den Bergh, Marjolein F Q, Verhulst, Carlo J M M, Rossen, John W A, Kluytmans, Jan A J W, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, Stohr, Joep J J M, Kluytmans-van den Bergh, Marjolein F Q, Verhulst, Carlo J M M, Rossen, John W A, and Kluytmans, Jan A J W

Published
2020

34. Detection of extended-spectrum beta-lactamase (ESBL) genes and plasmid replicons in Enterobacteriaceae using PlasmidSPAdes assembly of short-read sequence data

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Stohr, Joep J J M, Kluytmans-van den Bergh, Marjolein F Q, Wedema, Ronald, Friedrich, Alexander W, Kluytmans, Jan A J W, Rossen, John W A, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Stohr, Joep J J M, Kluytmans-van den Bergh, Marjolein F Q, Wedema, Ronald, Friedrich, Alexander W, Kluytmans, Jan A J W, and Rossen, John W A

Published
2020

35. Prevention of severe infectious complications after colorectal surgery using oral non-absorbable antimicrobial prophylaxis: Results of a multicenter randomized placebo-controlled clinical trial

Author

Unit Opleiding Aios, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, MMB, Biostatistiek Onderzoek, JC onderzoeksprogramma Methodologie, Epi Infectieziekten, Mulder, Tessa, Kluytmans-Van Den Bergh, Marjolein, Vlaminckx, Bart, Roos, Daphne, De Smet, Anne Marie, De Vos Tot Nederveen Cappel, Robert, Verheijen, Paul, Brandt, Alexandra, Smits, Anke, Van Der Vorm, Eric, Bathoorn, Erik, Van Etten, Boudewijn, Veenemans, Jacobien, Weersink, Annemarie, Vos, Margreet, Van 'T Veer, Nils, Nikolakopoulos, Stavros, Bonten, Marc, Kluytmans, Jan, Unit Opleiding Aios, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, MMB, Biostatistiek Onderzoek, JC onderzoeksprogramma Methodologie, Epi Infectieziekten, Mulder, Tessa, Kluytmans-Van Den Bergh, Marjolein, Vlaminckx, Bart, Roos, Daphne, De Smet, Anne Marie, De Vos Tot Nederveen Cappel, Robert, Verheijen, Paul, Brandt, Alexandra, Smits, Anke, Van Der Vorm, Eric, Bathoorn, Erik, Van Etten, Boudewijn, Veenemans, Jacobien, Weersink, Annemarie, Vos, Margreet, Van 'T Veer, Nils, Nikolakopoulos, Stavros, Bonten, Marc, and Kluytmans, Jan

Published
2020

38. Prevalence and Clinical Presentation of Health Care Workers With Symptoms of Coronavirus Disease 2019 in 2 Dutch Hospitals During an Early Phase of the Pandemic

Author

Kluytmans-van den Bergh, Marjolein F. Q., primary, Buiting, Anton G. M., additional, Pas, Suzan D., additional, Bentvelsen, Robbert G., additional, van den Bijllaardt, Wouter, additional, van Oudheusden, Anne J. G., additional, van Rijen, Miranda M. L., additional, Verweij, Jaco J., additional, Koopmans, Marion P. G., additional, and Kluytmans, Jan A. J. W., additional

Published
2020
Full Text
View/download PDF

39. COVID-19 in healthcare workers in three hospitals in the South of the Netherlands, March 2020

Author

Sikkema, Reina S., primary, Pas, Suzan, additional, Nieuwenhuijse, David F., additional, O’Toole, Áine, additional, Verweij, Jaco, additional, van der Linden, Anne, additional, Chestakova, Irina, additional, Schapendonk, Claudia, additional, Pronk, Mark, additional, Lexmond, Pascal, additional, Bestebroer, Theo, additional, Overmars, Ronald J., additional, van Nieuwkoop, Stefan, additional, van den Bijllaardt, Wouter, additional, Bentvelsen, Robbert G., additional, van Rijen, Miranda M.L., additional, Buiting, Anton G.M., additional, van Oudheusden, Anne J.G., additional, Diederen, Bram M., additional, Bergmans, Anneke M.C., additional, van der Eijk, Annemiek, additional, Molenkamp, Richard, additional, Rambaut, Andrew, additional, Timen, Aura, additional, Kluytmans, Jan A.J.W., additional, Oude Munnink, Bas B., additional, Kluytmans van den Bergh, Marjolein F.Q., additional, and Koopmans, Marion P.G., additional

Published
2020
Full Text
View/download PDF

40. SARS-CoV-2 infection in 86 healthcare workers in two Dutch hospitals in March 2020

Author

Kluytmans-van den Bergh, Marjolein F.Q., primary, Buiting, Anton G.M., additional, Pas, Suzan D., additional, Bentvelsen, Robbert G., additional, van den Bijllaardt, Wouter, additional, van Oudheusden, Anne J.G., additional, van Rijen, Miranda M.L., additional, Verweij, Jaco J., additional, Koopmans, Marion P.G., additional, and Kluytmans, Jan A.J.W., additional

Published
2020
Full Text
View/download PDF

41. Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum β-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study

Author

Kluytmans-van den Bergh, Marjolein F Q, primary, Bruijning-Verhagen, Patricia C J, additional, Vandenbroucke-Grauls, Christina M J E, additional, de Brauwer, Els I G B, additional, Buiting, Anton G M, additional, Diederen, Bram M, additional, van Elzakker, Erika P M, additional, Friedrich, Alex W, additional, Hopman, Joost, additional, al Naiemi, Nashwan, additional, Rossen, John W A, additional, Ruijs, Gijs J H M, additional, Savelkoul, Paul H M, additional, Verhulst, Carlo, additional, Vos, Margreet C, additional, Voss, Andreas, additional, Bonten, Marc J M, additional, Kluytmans, Jan A J W, additional, Bonten, Marc, additional, Bootsma, Martin, additional, de Brauwer, Els, additional, Bruijning-Verhagen, Patricia, additional, Buiting, Anton, additional, Diederen, Bram, additional, van Elzakker, Erika, additional, Friedrich, Alexander, additional, Kampinga, Greetje, additional, van Keulen, Peter, additional, Kluytmans, Jan, additional, Kluytmans-van den Bergh, Marjolein, additional, Oudhuis, Guy, additional, Raangs, Erwin, additional, Rosema, Sigrid, additional, Rossen, John, additional, Ruijs, Gijs, additional, Savelkoul, Paul, additional, Troelstra, Annet, additional, Vandenbroucke-Grauls, Christina, additional, Verduin, Kees, additional, Vos, Margreet, additional, Willems, Rob, additional, and Willemsen, Ina, additional

Published
2019
Full Text
View/download PDF

42. Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum β-lactamase-producing Enterobacteriaceae in Dutch hospitals : a cluster-randomised, crossover, non-inferiority study

Author

Kluytmans-van den Bergh, Marjolein, Bruijning-Verhagen, Patricia C.J., Vandenbroucke-Grauls, Christina, de Brauwer, Els I.G.B., Buiting, Anton G.M., Diederen, Bram M., van Elzakker, Erika P.M., Friedrich, Alex W., Hopman, Joost, al Naiemi, Nashwan, Rossen, John, Ruijs, Gijs J.H.M., Savelkoul, Paul H.M., Verhulst, Carlo, Vos, Margreet C., Voss, Andreas, Bonten, Marc, Kluytmans, Jan, Bootsma, Martin, de Brauwer, Els, Bruijning-Verhagen, Patricia, Buiting, Anton, Diederen, Bram, van Elzakker, Erika, Friedrich, Alexander, Kampinga, Greetje, van Keulen, Peter, Oudhuis, Guy, Raangs, Erwin, Rosema, Sigrid, Ruijs, Gijs, Troelstra, Annet, Verduin, Kees, Vos, Margreet, Willems, Rob, Willemsen, Ina, Kluytmans-van den Bergh, Marjolein, Bruijning-Verhagen, Patricia C.J., Vandenbroucke-Grauls, Christina, de Brauwer, Els I.G.B., Buiting, Anton G.M., Diederen, Bram M., van Elzakker, Erika P.M., Friedrich, Alex W., Hopman, Joost, al Naiemi, Nashwan, Rossen, John, Ruijs, Gijs J.H.M., Savelkoul, Paul H.M., Verhulst, Carlo, Vos, Margreet C., Voss, Andreas, Bonten, Marc, Kluytmans, Jan, Bootsma, Martin, de Brauwer, Els, Bruijning-Verhagen, Patricia, Buiting, Anton, Diederen, Bram, van Elzakker, Erika, Friedrich, Alexander, Kampinga, Greetje, van Keulen, Peter, Oudhuis, Guy, Raangs, Erwin, Rosema, Sigrid, Ruijs, Gijs, Troelstra, Annet, Verduin, Kees, Vos, Margreet, Willems, Rob, and Willemsen, Ina

Published
2019

43. Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum beta-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study

Author

Kluytmans-van den Bergh, Marjolein F.Q., Bruijning-Verhagen, Patricia C.J., Vandenbroucke-Grauls, C.M., Brauwer, Els I.G.B. de, Buiting, Anton G. M., Diederen, Bram M., Hopman, J., Voss, A., Bonten, Marc J. M., Kluytmans, Jan A. J. W., Kluytmans-van den Bergh, Marjolein F.Q., Bruijning-Verhagen, Patricia C.J., Vandenbroucke-Grauls, C.M., Brauwer, Els I.G.B. de, Buiting, Anton G. M., Diederen, Bram M., Hopman, J., Voss, A., Bonten, Marc J. M., and Kluytmans, Jan A. J. W.

Abstract

Item does not contain fulltext

Published
2019

45. Preoperative oral antibiotic prophylaxis reduces surgical site infections after elective colorectal surgery : results from a before-after study

Author

Mulder, Tessa, Crolla, Rogier M P H, Kluytmans-van den Bergh, Marjolein F Q, van Mourik, Maaike S M, Romme, Jannie, van der Schelling, George P, Kluytmans, Jan A J W, Mulder, Tessa, Crolla, Rogier M P H, Kluytmans-van den Bergh, Marjolein F Q, van Mourik, Maaike S M, Romme, Jannie, van der Schelling, George P, and Kluytmans, Jan A J W

Published
2019

46. Preoperative oral antibiotic prophylaxis reduces surgical site infections after elective colorectal surgery: results from a before-after study

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Onderzoek en Onderwijs, MMB opleiding Arts microbioloog, Mulder, Tessa, Crolla, Rogier M.P.H., Kluytmans-Van Den Bergh, Marjolein F.Q., Van Mourik, Maaike S.M., Romme, Jannie, Van Der Schelling, George P., Kluytmans, Jan A.J.W., Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB Onderzoek en Onderwijs, MMB opleiding Arts microbioloog, Mulder, Tessa, Crolla, Rogier M.P.H., Kluytmans-Van Den Bergh, Marjolein F.Q., Van Mourik, Maaike S.M., Romme, Jannie, Van Der Schelling, George P., and Kluytmans, Jan A.J.W.

Published
2019

47. A diagnostic algorithm for the surveillance of deep surgical site infections after colorectal surgery

Author

Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, MMB opleiding Arts microbioloog, MMB Research line 2, Epi Infectieziekten, MMB, Mulder, Tessa, Kluytmans-van den Bergh, Marjolein F. Q., van Mourik, Maaike S. M., Romme, Jannie, Crolla, Rogier M. P. H., Bonten, Marc J. M., Kluytmans, Jan A. J. W., Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 1, MMB opleiding Arts microbioloog, MMB Research line 2, Epi Infectieziekten, MMB, Mulder, Tessa, Kluytmans-van den Bergh, Marjolein F. Q., van Mourik, Maaike S. M., Romme, Jannie, Crolla, Rogier M. P. H., Bonten, Marc J. M., and Kluytmans, Jan A. J. W.

Published
2019

48. Prevention of severe infectious complications after colorectal surgery using preoperative orally administered antibiotic prophylaxis (PreCaution)

Author

Mulder, Tessa, Kluytmans-van den Bergh, Marjolein F Q, De Smet, Anne Marie G A, van 't Veer, Nils E, Roos, Daphne, Nikolakopoulos, Stavros, Bonten, Marc J M, Kluytmans, Jan A J W, PreCaution Study Group, Surgery, Medical Microbiology & Infectious Diseases, Microbes in Health and Disease (MHD), and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Subjects
Male, Time Factors, DIGESTIVE-TRACT, Administration, Oral, Medicine (miscellaneous), Infection control, law.invention, Study Protocol, 0302 clinical medicine, Randomized controlled trial, Risk Factors, Colon surgery, law, Clinical endpoint, Pharmacology (medical), Cumulative incidence, 030212 general & internal medicine, Antibiotic prophylaxis, Colectomy, Digestive System Surgical Procedures, Netherlands, Randomized Controlled Trials as Topic, lcsh:R5-920, SELECTIVE DECONTAMINATION, Preoperative oral antibiotic prophylaxis, Incidence, INTENSIVE-CARE UNITS, Colorectal surgery, Anti-Bacterial Agents, Drug Combinations, Treatment Outcome, 030220 oncology & carcinogenesis, SURGICAL SITE INFECTIONS, Tobramycin, Female, lcsh:Medicine (General), Surgical site infection, OROPHARYNX, medicine.medical_specialty, Colon, Drug intervention trial, Drug Administration Schedule, CLINICAL-TRIAL, 03 medical and health sciences, Double-Blind Method, Internal medicine, medicine, Humans, Surgical Wound Infection, Mortality, Placebo, METAANALYSIS, MECHANICAL BOWEL PREPARATION, Colistin, business.industry, Rectum, Perioperative, Antibiotic Prophylaxis, Clinical trial, COLON SURGERY, business, RESISTANCE
Abstract

Background Colorectal surgery is frequently complicated by surgical site infections (SSIs). The most important consequences of SSIs are prolonged hospitalization, an increased risk of surgical reintervention and an increase in mortality. Perioperative intravenously administered antibiotic prophylaxis is the standard of care to reduce the risk of SSIs. In the last few decades, preoperative orally administered antibiotics have been suggested as additional prophylaxis to further reduce the risk of infection, but are currently not part of routine practice in most hospitals. The objective of this study is to evaluate the efficacy of a preoperative orally administered antibiotic prophylaxis (Pre-OP) in addition to intravenously administered perioperative antibiotic prophylaxis to reduce the incidence of deep SSIs and/or mortality after elective colorectal surgery. Methods/design The PreCaution trial is designed as a multicenter, double-blind, randomized, placebo-controlled clinical trial that will be carried out in The Netherlands. Adult patients who are scheduled for elective colorectal surgery are eligible to participate. In total, 966 patients will be randomized to receive the study medication. This will either be Pre-OP, a solution that consists of tobramycin and colistin sulphate, or a placebo solution. The study medication will be administered four times daily during the 3 days prior to surgery. Perioperative intravenously administered antibiotic prophylaxis will be administered to all patients in accordance with national infection control guidelines. The primary endpoint of the study is the cumulative incidence of deep SSIs and/or mortality within 30 days after surgery. Secondary endpoints include both infectious and non-infectious complications of colorectal surgery, and will be evaluated 30 days and/or 6 months after surgery. Discussion To date, conclusive evidence on the added value of preoperative orally administered antibiotic prophylaxis in colorectal surgery is lacking. The PreCaution trial should determine the effects of orally administered antibiotics in preventing infectious complications in elective colorectal surgery. Trial registration Netherlands Trial Register, ID: NTR6113. Registered on 11 October 2016; EudraCT 2015-005736-17. Electronic supplementary material The online version of this article (doi:10.1186/s13063-018-2439-4) contains supplementary material, which is available to authorized users.

Published
2018

49. Quantifying Hospital-Acquired Carriage of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Among Patients in Dutch Hospitals

Author

Kluytmans-van den Bergh, Marjolein F Q, van Mens, Suzan P, Haverkate, Manon R, Bootsma, Martin C J, Kluytmans, Jan A J W, Bonten, Marc J M, and SoM Study Group

Abstract

BACKGROUND Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are emerging worldwide. Contact precautions are recommended for known ESBL-E carriers to control the spread of ESBL-E within hospitals. OBJECTIVE This study quantified the acquisition of ESBL-E rectal carriage among patients in Dutch hospitals, given the application of contact precautions. METHODS Data were used from 2 cluster-randomized studies on isolation strategies for ESBL-E: (1) the SoM study, performed in 14 Dutch hospitals from 2011 through 2014 and (2) the R-GNOSIS study, for which data were limited to those collected in a Dutch hospital in 2014. Perianal cultures were obtained, either during ward-based prevalence surveys (SoM), or at admission and twice weekly thereafter (R-GNOSIS). In both studies, contact precautions were applied to all known ESBL-E carriers. Estimates for acquisition of ESBL-E were based on the results of admission and discharge cultures from patients hospitalized for more than 2 days (both studies) and a Markov chain Monte Carlo (MCMC) model, applied to all patients hospitalized (R-GNOSIS). RESULTS The absolute risk of acquisition of ESBL-E rectal carriage ranged from 2.4% to 2.9% with an ESBL-E acquisition rate of 2.8 to 3.8 acquisitions per 1,000 patient days. In addition, 28% of acquisitions were attributable to patient-dependent transmission, and the per-admission reproduction number was 0.06. CONCLUSIONS The low ESBL-E acquisition rate in this study demonstrates that it is possible to control the nosocomial transmission of ESBL in a low-endemic, non-ICU setting where Escherichia coli is the most prevalent ESBL-E and standard and contact precautions are applied for known ESBL-E carriers. TRIAL REGISTRATION Nederlands Trialregister, NTR2799, http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2799; ISRCTN Registry, ISRCTN57648070, http://www.isrctn.com/ISRCTN57648070 Infect Control Hosp Epidemiol 2017;1-8.

Published
2018

50. Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands

Author

Huizinga, Pepijn, primary, Kluytmans-van den Bergh, Marjolein, additional, Rossen, John W., additional, Willemsen, Ina, additional, Verhulst, Carlo, additional, Savelkoul, Paul H. M., additional, Friedrich, Alexander W., additional, García-Cobos, Silvia, additional, and Kluytmans, Jan, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results