309 results on '"Klivenyi, Peter"'
Search Results
2. Effect of 3-nitropropionic acid on sirtuin gene expression in Sirt3 deficient mice
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Horváth, Orsolya and Klivényi, Péter
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- 2024
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3. Genetic landscape of early-onset dementia in Hungary
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Csaban, Dora, Illes, Anett, Renata, Toth-Bencsik, Balicza, Peter, Pentelenyi, Klara, Molnar, Viktor, Gezsi, Andras, Grosz, Zoltan, Gal, Aniko, Kovacs, Tibor, Klivenyi, Peter, and Molnar, Maria Judit
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- 2022
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4. Neuroprotection by Kynurenine Metabolites
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Majláth, Zsófia, Szalárdy, Levente, Zádori, Dénes, Klivényi, Péter, Fülöp, Ferenc, Toldi, József, Vécsei, László, and Kostrzewa, Richard M., editor
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- 2022
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5. Real-world operation of multiple sclerosis centres in Central-Eastern European countries covering 107 million inhabitants
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Kokas, Zsófia, Járdánházy, Anett, Sandi, Dániel, Biernacki, Tamás, Fricska-Nagy, Zsanett, Füvesi, Judit, Bartosik-Psujek, Halina, Kes, Vanja Basic, Berger, Thomas, Berthele, Achim, Drulovic, Jelena, Hemmer, Bernhard, Horakova, Dana, Ledinek, Alenka Horvat, Havrdova, Eva Kubala, Magyari, Melinda, Rejdak, Konrad, Tiu, Cristina, Turcani, Peter, Klivényi, Péter, Kincses, Zsigmond Tamás, Vécsei, László, and Bencsik, Krisztina
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- 2023
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6. Cladribine tablets in people with relapsing multiple sclerosis: A real-world multicentric study from southeast European MS centers
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Adamec, Ivan, Jakob, Gregor Brecl, Rajda, Cecilia, Drulović, Jelena, Radulović, Ljiljana, Kes, Vanja Bašić, Lazibat, Ines, Rimac, Julija, Cindrić, Igor, Gržinčić, Tihana, Abičić, Ana, Barun, Barbara, Gabelić, Tereza, Gomezelj, Sarah, Mesaroš, Šarlota, Pekmezović, Tatjana, Klivényi, Péter, Skorić, Magdalena Krbot, and Habek, Mario
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- 2023
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7. DWI-FLAIR mismatch guided thrombolysis in patients without large-vessel occlusion: real-world data from a comprehensive stroke centre
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Annus, Ádám, Gera, Franciska Zita, Sztriha, László, and Klivényi, Péter
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- 2022
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8. Re-analysis of the Hungarian amyotrophic lateral sclerosis population and evaluation of novel ALS genetic risk variants
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Nagy, Zsófia Flóra, Pál, Margit, Salamon, András, Kafui Esi Zodanu, Gloria, Füstös, Dalma, Klivényi, Péter, and Széll, Márta
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- 2022
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9. p.L1795F LRRK2 variant is a common cause of Parkinson’s disease in Central Europe
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Ostrozovicova, Miriam, primary, Tamas, Gertrud, additional, Dušek, Petr, additional, Grofik, Milan, additional, Han, Vladimir, additional, Holly, Petr, additional, Jech, Robert, additional, Kalinova, Katarina, additional, Klivenyi, Peter, additional, Kovacs, Norbert, additional, Kulcsarova, Kristina, additional, Kurca, Egon, additional, Lackova, Alexandra, additional, Lee, Hamin, additional, Lewis, Patrick, additional, Magocova, Veronika, additional, Marekova, Maria, additional, Murphy, David, additional, Necpal, Jan, additional, Pinter, David, additional, Rabajdova, Miroslava, additional, Růžička, Evžen, additional, Serranova, Tereza, additional, Smilowska, Katarzyna, additional, Soos, Krisztina, additional, Straka, Igor, additional, Svorenova, Tatiana, additional, Valkovic, Peter, additional, Zarubova, Katerina, additional, Gdovinova, Zuzana, additional, Houlden, Henry, additional, Rizig, Mie, additional, and Skorvanek, Matei, additional
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- 2024
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10. Voxel-based asymmetry of the regional gray matter over the inferior temporal gyrus correlates with depressive symptoms in medicated patients with major depressive disorder
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Kocsis, Krisztián, Holczer, Adrienn, Kazinczi, Csaba, Boross, Katalin, Horváth, Regina, Németh, Luca Viola, Klivényi, Péter, Kincses, Zsigmond Tamás, and Must, Anita
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- 2021
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11. Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma
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Polyák, Helga, Cseh, Edina Katalin, Bohár, Zsuzsanna, Rajda, Cecilia, Zádori, Dénes, Klivényi, Péter, Toldi, József, and Vécsei, László
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- 2021
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12. Connection between small vessel disease related stroke and the MTHFR C677T polymorphism in a Hungarian population
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Annus, Ádám, Juhász, Lilla Ágnes, Szabó, Elza, Rárosi, Ferenc, Szpisjak, László, Vécsei, László, and Klivényi, Péter
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- 2020
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13. The assessment of possible gender-related effect of endogenous striatal alpha-tocopherol level on MPTP neurotoxicity in mice
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Nánási, Nikolett, Veres, Gábor, Cseh, Edina K., Martos, Diána, Hadady, Levente, Klivényi, Péter, Vécsei, László, and Zádori, Dénes
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- 2020
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14. Identifying diagnostic and prognostic factors in cerebral amyloid angiopathy‐related inflammation: A systematic analysis of published and seven new cases
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Szalardy, Levente, primary, Fakan, Bernadett, additional, Maszlag‐Torok, Rita, additional, Ferencz, Emil, additional, Reisz, Zita, additional, Radics, Bence L., additional, Csizmadia, Sandor, additional, Szpisjak, Laszlo, additional, Annus, Adam, additional, Zadori, Denes, additional, Kovacs, Gabor G., additional, and Klivenyi, Peter, additional
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- 2024
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15. Central European Group on Genetics of Movement Disorders
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Ostrozovicova, Miriam, primary, Dusek, Petr, additional, Grofik, Milan, additional, Han, Vladimir, additional, Holly, Petr, additional, Jech, Robert, additional, Klivenyi, Peter, additional, Kovacs, Norbert, additional, Kulcsarova, Kristina, additional, Kurca, Egon, additional, Lackova, Alexandra, additional, Magocova, Veronika, additional, Necpal, Jan, additional, Pinter, David, additional, Ruzicka, Evzen, additional, Serranova, Tereza, additional, Smilowska, Katarzyna, additional, Straka, Igor, additional, Svorenova, Tatiana, additional, Tamas, Gertrud, additional, Valkovic, Peter, additional, Zarubova, Katerina, additional, Houlden, Henry, additional, Rizig, Mie, additional, and Skorvanek, Matej, additional
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- 2023
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16. Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study
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Szpisjak, Laszlo, Szaraz, Gabor, Salamon, Andras, Nemeth, Viola L., Szepfalusi, Noemi, Veres, Gabor, Kincses, Balint, Maroti, Zoltan, Kalmar, Tibor, Rydzanicz, Malgorzata, Ploski, Rafal, Klivenyi, Peter, and Zadori, Denes
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- 2021
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17. Correction to: Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study
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Szpisjak, Laszlo, Szaraz, Gabor, Salamon, Andras, Nemeth, Viola L., Szepfalusi, Noemi, Veres, Gabor, Kincses, Balint, Maroti, Zoltan, Kalmar, Tibor, Rydzanicz, Malgorzata, Ploski, Rafal, Klivenyi, Peter, and Zadori, Denes
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- 2021
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18. Predictors of localization, outcome, and etiology of spontaneous intracerebral hemorrhages: focus on cerebral amyloid angiopathy
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Fakan, Bernadett, Reisz, Zita, Zadori, Denes, Vecsei, Laszlo, Klivenyi, Peter, and Szalardy, Levente
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- 2020
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19. 24-Hour Near-Infrared Spectroscopy Monitoring of Acute Ischaemic Stroke Patients Undergoing Thrombolysis or Thrombectomy: A Pilot Study
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Annus, Ádám, Nagy, András, Vécsei, László, and Klivényi, Péter
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- 2019
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20. Central European Group on Genetics of Movement Disorders.
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Ostrozovicova, Miriam, Dusek, Petr, Grofik, Milan, Han, Vladimir, Holly, Petr, Jech, Robert, Klivenyi, Peter, Kovacs, Norbert, Kulcsarova, Kristina, Kurca, Egon, Lackova, Alexandra, Magocova, Veronika, Necpal, Jan, Pinter, David, Ruzicka, Evzen, Serranova, Tereza, Smilowska, Katarzyna, Straka, Igor, Svorenova, Tatiana, and Tamas, Gertrud
- Subjects
MOVEMENT disorders ,PROGRESSIVE supranuclear palsy ,GENETICS ,RAPID eye movement sleep - Abstract
The Central European Group on Genetics of Movement Disorders (CEGEMOD) has been established to address the lack of genetic reports from patients of Central European ancestry in the study of movement disorders. The consortium aims to create a collaborative network that will establish a registry of movement disorder patients, with a focus on Parkinson's disease and other related conditions. The goal is to identify genetic risk factors and explore genotype-phenotype correlations to develop new diagnostic and therapeutic interventions. The consortium has already enrolled nearly 3500 individuals, making it the largest ethnically matched case-control cohort in Central Europe. [Extracted from the article]
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- 2024
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21. Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project
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Vollstedt, Eva-Juliane, primary, Madoev, Harutyun, additional, Aasly, Anna, additional, Ahmad-Annuar, Azlina, additional, Al-Mubarak, Bashayer, additional, Alcalay, Roy N., additional, Alvarez, Victoria, additional, Amorin, Ignacio, additional, Annesi, Grazia, additional, Arkadir, David, additional, Bardien, Soraya, additional, Barker, Roger A., additional, Barkhuizen, Melinda, additional, Basak, A. Nazli, additional, Bonifati, Vincenzo, additional, Boon, Agnita, additional, Brighina, Laura, additional, Brockmann, Kathrin, additional, Carmine Belin, Andrea, additional, Carr, Jonathan, additional, Clarimon, Jordi, additional, Cornejo-Olivas, Mario, additional, Correia Guedes, Leonor, additional, Corvol, Jean-Christophe, additional, Crosiers, David, additional, Damásio, Joana, additional, Das, Parimal, additional, de Carvalho Aguiar, Patricia, additional, De Rosa, Anna, additional, Dorszewska, Jolanta, additional, Ertan, Sibel, additional, Ferese, Rosangela, additional, Ferreira, Joaquim, additional, Gatto, Emilia, additional, Genç, Gençer, additional, Giladi, Nir, additional, Gómez-Garre, Pilar, additional, Hanagasi, Hasmet, additional, Hattori, Nobutaka, additional, Hentati, Faycal, additional, Hoffman-Zacharska, Dorota, additional, Illarioshkin, Sergey N., additional, Jankovic, Joseph, additional, Jesús, Silvia, additional, Kaasinen, Valtteri, additional, Kievit, Anneke, additional, Klivenyi, Peter, additional, Kostic, Vladimir, additional, Koziorowski, Dariusz, additional, Kühn, Andrea A., additional, Lang, Anthony E., additional, Lim, Shen-Yang, additional, Lin, Chin-Hsien, additional, Lohmann, Katja, additional, Markovic, Vladana, additional, Martikainen, Mika Henrik, additional, Mellick, George, additional, Merello, Marcelo, additional, Milanowski, Lukasz, additional, Mir, Pablo, additional, Öztop-Çakmak, Özgür, additional, Pimentel, Márcia Mattos Gonçalves, additional, Pulkes, Teeratorn, additional, Puschmann, Andreas, additional, Rogaeva, Ekaterina, additional, Sammler, Esther M., additional, Skaalum Petersen, Maria, additional, Skorvanek, Matej, additional, Spitz, Mariana, additional, Suchowersky, Oksana, additional, Tan, Ai Huey, additional, Termsarasab, Pichet, additional, Thaler, Avner, additional, Tumas, Vitor, additional, Valente, Enza Maria, additional, van de Warrenburg, Bart, additional, Williams-Gray, Caroline H., additional, Wu, Ruey-Mei, additional, Zhang, Baorong, additional, Zimprich, Alexander, additional, Solle, Justin, additional, Padmanabhan, Shalini, additional, and Klein, Christine, additional
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- 2023
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22. Correction to: Predictors of localization, outcome, and etiology of spontaneous intracerebral hemorrhages: focus on cerebral amyloid angiopathy
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Fakan, Bernadett, Reisz, Zita, Zadori, Denes, Vecsei, Laszlo, Klivenyi, Peter, and Szalardy, Levente
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- 2020
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23. Pediatric multiple sclerosis and fulminant disease course: Features and approaches to treatment – A case report and review of the literature
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Sandi, Dániel, Bereg, Edit, Biernacki, Tamás, Vörös, Erika, Klivényi, Péter, Bereczki, Csaba, Vécsei, László, and Bencsik, Krisztina
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- 2018
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24. Levodopa/carbidopa intestinal gel can improve both motor and non-motor experiences of daily living in Parkinson’s disease: An open-label study
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Juhász, Annamária, Aschermann, Zsuzsanna, Ács, Péter, Janszky, József, Kovács, Márton, Makkos, Attila, Harmat, Márk, Tényi, Dalma, Karádi, Kázmér, Komoly, Sámuel, Takáts, Annamária, Tóth, Adrián, Nagy, Helga, Klivényi, Péter, Dibó, György, Dézsi, Lívia, Zádori, Dénes, Annus, Ádám, Vécsei, László, Varannai, Lajos, and Kovács, Norbert
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- 2017
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25. Autosomal Recessive Cerebellar Ataxias in Europe: Frequency, Onset, and Severity in 677 Patients
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Traschütz, Andreas, primary, Adarmes‐Gomez, Astrid D., additional, Anheim, Mathieu, additional, Baets, Jonathan, additional, Falkenburger, Björn H., additional, Gburek‐Augustat, Janina, additional, Doss, Sarah, additional, Kamm, Christoph, additional, Klivenyi, Peter, additional, Grobe‐Einsler, Marcus, additional, Klopstock, Thomas, additional, Minnerop, Martina, additional, Münchau, Alexander, additional, Pane, Chiara, additional, Renaud, Mathilde, additional, Santorelli, Filippo M., additional, Schöls, Ludger, additional, Timmann, Dagmar, additional, Vielhaber, Stefan, additional, Haack, Tobias B., additional, van de Warrenburg, Bart P., additional, Zanni, Ginevra, additional, and Synofzik, Matthis, additional
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- 2023
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26. Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations:Experience from the MJFF Global Genetic Parkinson's Disease Project
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Vollstedt, Eva Juliane, Madoev, Harutyun, Aasly, Anna, Ahmad-Annuar, Azlina, Al-Mubarak, Bashayer, Alcalay, Roy N., Alvarez, Victoria, Amorin, Ignacio, Annesi, Grazia, Arkadir, David, Bardien, Soraya, Barker, Roger A., Barkhuizen, Melinda, Basak, A. Nazli, Bonifati, Vincenzo, Boon, Agnita, Brighina, Laura, Brockmann, Kathrin, Carmine Belin, Andrea, Carr, Jonathan, Clarimon, Jordi, Cornejo-Olivas, Mario, Correia Guedes, Leonor, Corvol, Jean Christophe, Crosiers, David, Damásio, Joana, Das, Parimal, de Carvalho Aguiar, Patricia, De Rosa, Anna, Dorszewska, Jolanta, Ertan, Sibel, Ferese, Rosangela, Ferreira, Joaquim, Gatto, Emilia, Genç, Gençer, Giladi, Nir, Gómez-Garre, Pilar, Hanagasi, Hasmet, Hattori, Nobutaka, Hentati, Faycal, Hoffman-Zacharska, Dorota, Illarioshkin, Sergey N., Jankovic, Joseph, Jesús, Silvia, Kaasinen, Valtteri, Kievit, Anneke, Klivenyi, Peter, Kostic, Vladimir, Koziorowski, Dariusz, Kühn, Andrea A., Lang, Anthony E., Lim, Shen Yang, Lin, Chin Hsien, Lohmann, Katja, Markovic, Vladana, Martikainen, Mika Henrik, Mellick, George, Merello, Marcelo, Milanowski, Lukasz, Mir, Pablo, Öztop-Çakmak, Özgür, Pimentel, Márcia Mattos Gonçalves, Pulkes, Teeratorn, Puschmann, Andreas, Rogaeva, Ekaterina, Sammler, Esther M., Skaalum Petersen, Maria, Skorvanek, Matej, Spitz, Mariana, Suchowersky, Oksana, Tan, Ai Huey, Termsarasab, Pichet, Thaler, Avner, Tumas, Vitor, Valente, Enza Maria, van de Warrenburg, Bart, Williams-Gray, Caroline H., Wu, Ruey Mei, Zhang, Baorong, Zimprich, Alexander, Solle, Justin, Padmanabhan, Shalini, Klein, Christine, Vollstedt, Eva Juliane, Madoev, Harutyun, Aasly, Anna, Ahmad-Annuar, Azlina, Al-Mubarak, Bashayer, Alcalay, Roy N., Alvarez, Victoria, Amorin, Ignacio, Annesi, Grazia, Arkadir, David, Bardien, Soraya, Barker, Roger A., Barkhuizen, Melinda, Basak, A. Nazli, Bonifati, Vincenzo, Boon, Agnita, Brighina, Laura, Brockmann, Kathrin, Carmine Belin, Andrea, Carr, Jonathan, Clarimon, Jordi, Cornejo-Olivas, Mario, Correia Guedes, Leonor, Corvol, Jean Christophe, Crosiers, David, Damásio, Joana, Das, Parimal, de Carvalho Aguiar, Patricia, De Rosa, Anna, Dorszewska, Jolanta, Ertan, Sibel, Ferese, Rosangela, Ferreira, Joaquim, Gatto, Emilia, Genç, Gençer, Giladi, Nir, Gómez-Garre, Pilar, Hanagasi, Hasmet, Hattori, Nobutaka, Hentati, Faycal, Hoffman-Zacharska, Dorota, Illarioshkin, Sergey N., Jankovic, Joseph, Jesús, Silvia, Kaasinen, Valtteri, Kievit, Anneke, Klivenyi, Peter, Kostic, Vladimir, Koziorowski, Dariusz, Kühn, Andrea A., Lang, Anthony E., Lim, Shen Yang, Lin, Chin Hsien, Lohmann, Katja, Markovic, Vladana, Martikainen, Mika Henrik, Mellick, George, Merello, Marcelo, Milanowski, Lukasz, Mir, Pablo, Öztop-Çakmak, Özgür, Pimentel, Márcia Mattos Gonçalves, Pulkes, Teeratorn, Puschmann, Andreas, Rogaeva, Ekaterina, Sammler, Esther M., Skaalum Petersen, Maria, Skorvanek, Matej, Spitz, Mariana, Suchowersky, Oksana, Tan, Ai Huey, Termsarasab, Pichet, Thaler, Avner, Tumas, Vitor, Valente, Enza Maria, van de Warrenburg, Bart, Williams-Gray, Caroline H., Wu, Ruey Mei, Zhang, Baorong, Zimprich, Alexander, Solle, Justin, Padmanabhan, Shalini, and Klein, Christine
- Abstract
Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder, currently affecting ~7 million people worldwide. PD is clinically and genetically heterogeneous, with at least 10% of all cases explained by a monogenic cause or strong genetic risk factor. However, the vast majority of our present data on monogenic PD is based on the investigation of patients of European White ancestry, leaving a large knowledge gap on monogenic PD in underrepresented populations. Gene-targeted therapies are being developed at a fast pace and have started entering clinical trials. In light of these developments, building a global network of centers working on monogenic PD, fostering collaborative research, and establishing a clinical trial-ready cohort is imperative. Based on a systematic review of the English literature on monogenic PD and a successful team science approach, we have built up a network of 59 sites worldwide and have collected information on the availability of data, biomaterials, and facilities. To enable access to this resource and to foster collaboration across centers, as well as between academia and industry, we have developed an interactive map and online tool allowing for a quick overview of available resources, along with an option to filter for specific items of interest. This initiative is currently being merged with the Global Parkinson's Genetics Program (GP2), which will attract additional centers with a focus on underrepresented sites. This growing resource and tool will facilitate collaborative research and impact the development and testing of new therapies for monogenic and potentially for idiopathic PD patients.
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- 2023
27. Responsiveness of the Scale for the Assessment and Rating of Ataxia and Natural History in 884 Recessive and Early Onset Ataxia Patients
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Federal Ministry of Education and Research (Germany), German Research Foundation, University of Tübingen, Research Foundation - Flanders, European Commission, Ministero della Salute, Ministry of Innovation and Technology (Hungary), University of Szeged, Traschütz, Andreas, Adarmes Gómez, A. D., Anheim, Mathieu, Baets, Jonathan, Brais, Bernard, Gagnon, Cynthia, Gburek-Augustat, Janina, Doss, Sarah, Hanagasi, Hasmet, Kamm, Christoph, Klivenyi, Peter, Klockgether, Thomas, Klopstock, Thomas, Minnerop, Martina, Münchau, Alexander, Renaud, Mathilde, Santorelli, Filippo M., Schöls, Ludger, Thieme, Andreas, Vielhaber, Stefan, Warrenburg, Bart van de, Zanni, Ginevra, Hilgers, Ralf-Dieter, PREPARE Consortium, Synofzik, Matthis, Federal Ministry of Education and Research (Germany), German Research Foundation, University of Tübingen, Research Foundation - Flanders, European Commission, Ministero della Salute, Ministry of Innovation and Technology (Hungary), University of Szeged, Traschütz, Andreas, Adarmes Gómez, A. D., Anheim, Mathieu, Baets, Jonathan, Brais, Bernard, Gagnon, Cynthia, Gburek-Augustat, Janina, Doss, Sarah, Hanagasi, Hasmet, Kamm, Christoph, Klivenyi, Peter, Klockgether, Thomas, Klopstock, Thomas, Minnerop, Martina, Münchau, Alexander, Renaud, Mathilde, Santorelli, Filippo M., Schöls, Ludger, Thieme, Andreas, Vielhaber, Stefan, Warrenburg, Bart van de, Zanni, Ginevra, Hilgers, Ralf-Dieter, PREPARE Consortium, and Synofzik, Matthis
- Abstract
[Objective] The Scale for the Assessment and Rating of Ataxia (SARA) is the most widely applied clinical outcome assessment (COA) for genetic ataxias, but presents metrological and regulatory challenges. To facilitate trial planning, we characterize its responsiveness (including subitem-level relations to ataxia severity and patient-focused outcomes) across a large number of ataxias, and provide first natural history data for several of them., [Methods] Subitem-level correlation and distribution-based analysis of 1,637 SARA assessments in 884 patients with autosomal recessive/early onset ataxia (370 with 2–8 longitudinal assessments) were complemented by linear mixed effects modeling to estimate progression and sample sizes., [Results] Although SARA subitem responsiveness varied between ataxia severities, gait/stance showed a robust granular linear scaling across the broadest range (SARA < 25). Responsiveness was diminished by incomplete subscale use at intermediate or upper levels, nontransitions (“static periods”), and fluctuating decreases/increases. All subitems except nose-finger showed moderate-to-strong correlations to activities of daily living, indicating that metric properties—not content validity—limit SARA responsiveness. SARA captured mild-to-moderate progression in many genotypes (eg, SYNE1-ataxia: 0.55 points/yr, ataxia with oculomotor apraxia type 2: 1.14 points/yr, POLG-ataxia: 1.56 points/yr), but no change in others (autosomal recessive spastic ataxia of Charlevoix-Saguenay, COQ8A-ataxia). Whereas sensitivity to change was optimal in mild ataxia (SARA < 10), it substantially deteriorated in advanced ataxia (SARA > 25; 2.7-fold sample size). Use of a novel rank-optimized SARA without subitems finger-chase and nose-finger reduces sample sizes by 20 to 25%., [Interpretation] This study comprehensively characterizes COA properties and annualized changes of the SARA across and within a large number of ataxias. It suggests specific approaches for optimizing its responsiveness that might facilitate regulatory qualification and trial design. ANN NEUROL 2023;94:470–485
- Published
- 2023
28. Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson's Disease Project
- Author
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Michael J. Fox Foundation for Parkinson's Research, Cambridge Biomedical Research Centre, National Institute for Health and Care Research (US), Vollstedt, Eva-Juliane, Madoev, Harutyun, Aasly, Anna, Ahmad-Annuar, Azlina, Al-Mubarak, Bashayer, Alcalay, Roy N., Álvarez, Victoria, Amorín, Ignacio, Annesi, Grazia, Arkadir, David, Bardien, Soraya, Barker, Roger A., Barkhuizen, Melinda, Basak, A. Nazli, Bonifati, Vincenzo, Boon, Agnita, Brighina, Laura, Brockmann, Kathrin, Carmine Belin, Andrea, Carr, Jonathan, Clarimon, Jordi, Cornejo-Olivas, Mario, Correia Guedes, Leonor, Corvol, Jean-Christophe, Crosiers, David, Damásio, Joana, Das, Parimal, Aguiar, Patricia de Carvalho, Rosa, Anna De, Dorszewska, Jolanta, Ertan, Sibel, Ferese, Rosangela, Ferreira, Joaquim, Gatto, Emilia, Genç, Gençer, Giladi, Nir, Gómez-Garre, Pilar, Hanagasi, Hasmet, Hattori, Nobutaka, Hentati, Faycal, Hoffman-Zacharska, Dorota, Illarioshkin, Sergey N., Jankovic, Joseph, Jesús Maestre, Silvia, Kaasinen, Valtteri, Kievit, Anneke, Klivenyi, Peter, Kostic, Vladimir, Koziorowski, Dariusz, Kühn, Andrea A., Lang, Anthony E., Lim, Shen-Yang, Lin, Chin-Hsien, Lohmann, Katja, Markovic, Vladana, Martikainen, Mika Henrik, Mellick, George, Merello, Marcelo, Milanowski, Lukasz, Mir, Pablo, Öztop-Çakmak, Özgür, Pimentel, Márcia Mattos Gonçalves, Pulkes, Teeratorn, Puschmann, Andreas, Rogaeva, Ekaterina, Sammler, Esther M., Skaalum Petersen, Maria, Skorvanek, Matej, Spitz, Mariana, Suchowersky, Oksana, Tan, Ai Huey, Termsarasab, Pichet, Thaler, Avner, Tumas, Vitor, Valente, Enza Maria, Warrenburg, Bart van de, Williams-Gray, Caroline H., Wu, Ruey-Mei, Zhang, Baorong, Zimprich, Alexander, Solle, Justin, Padmanabhan, Shalini, Klein, Christine, Michael J. Fox Foundation for Parkinson's Research, Cambridge Biomedical Research Centre, National Institute for Health and Care Research (US), Vollstedt, Eva-Juliane, Madoev, Harutyun, Aasly, Anna, Ahmad-Annuar, Azlina, Al-Mubarak, Bashayer, Alcalay, Roy N., Álvarez, Victoria, Amorín, Ignacio, Annesi, Grazia, Arkadir, David, Bardien, Soraya, Barker, Roger A., Barkhuizen, Melinda, Basak, A. Nazli, Bonifati, Vincenzo, Boon, Agnita, Brighina, Laura, Brockmann, Kathrin, Carmine Belin, Andrea, Carr, Jonathan, Clarimon, Jordi, Cornejo-Olivas, Mario, Correia Guedes, Leonor, Corvol, Jean-Christophe, Crosiers, David, Damásio, Joana, Das, Parimal, Aguiar, Patricia de Carvalho, Rosa, Anna De, Dorszewska, Jolanta, Ertan, Sibel, Ferese, Rosangela, Ferreira, Joaquim, Gatto, Emilia, Genç, Gençer, Giladi, Nir, Gómez-Garre, Pilar, Hanagasi, Hasmet, Hattori, Nobutaka, Hentati, Faycal, Hoffman-Zacharska, Dorota, Illarioshkin, Sergey N., Jankovic, Joseph, Jesús Maestre, Silvia, Kaasinen, Valtteri, Kievit, Anneke, Klivenyi, Peter, Kostic, Vladimir, Koziorowski, Dariusz, Kühn, Andrea A., Lang, Anthony E., Lim, Shen-Yang, Lin, Chin-Hsien, Lohmann, Katja, Markovic, Vladana, Martikainen, Mika Henrik, Mellick, George, Merello, Marcelo, Milanowski, Lukasz, Mir, Pablo, Öztop-Çakmak, Özgür, Pimentel, Márcia Mattos Gonçalves, Pulkes, Teeratorn, Puschmann, Andreas, Rogaeva, Ekaterina, Sammler, Esther M., Skaalum Petersen, Maria, Skorvanek, Matej, Spitz, Mariana, Suchowersky, Oksana, Tan, Ai Huey, Termsarasab, Pichet, Thaler, Avner, Tumas, Vitor, Valente, Enza Maria, Warrenburg, Bart van de, Williams-Gray, Caroline H., Wu, Ruey-Mei, Zhang, Baorong, Zimprich, Alexander, Solle, Justin, Padmanabhan, Shalini, and Klein, Christine
- Abstract
Parkinson’s disease (PD) is the fastest-growing neurodegenerative disorder, currently affecting ~7 million people worldwide. PD is clinically and genetically heterogeneous, with at least 10% of all cases explained by a monogenic cause or strong genetic risk factor. However, the vast majority of our present data on monogenic PD is based on the investigation of patients of European White ancestry, leaving a large knowledge gap on monogenic PD in underrepresented populations. Gene-targeted therapies are being developed at a fast pace and have started entering clinical trials. In light of these developments, building a global network of centers working on monogenic PD, fostering collaborative research, and establishing a clinical trial-ready cohort is imperative. Based on a systematic review of the English literature on monogenic PD and a successful team science approach, we have built up a network of 59 sites worldwide and have collected information on the availability of data, biomaterials, and facilities. To enable access to this resource and to foster collaboration across centers, as well as between academia and industry, we have developed an interactive map and online tool allowing for a quick overview of available resources, along with an option to filter for specific items of interest. This initiative is currently being merged with the Global Parkinson’s Genetics Program (GP2), which will attract additional centers with a focus on underrepresented sites. This growing resource and tool will facilitate collaborative research and impact the development and testing of new therapies for monogenic and potentially for idiopathic PD patients.
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- 2023
29. Autosomal Recessive Cerebellar Ataxias in Europe: Frequency, Onset, and Severity in 677 Patients
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European Commission, Federal Ministry of Education and Research (Germany), ZonMw, Dutch Research Council, Brain Foundation (The Netherlands), Jacques and Gloria Gossweiler Foundation, Radboud University, University of Tübingen, University of Szeged, Ministry of Innovation and Technology (Hungary), Research Foundation - Flanders, Ministero della Salute, Projekt DEAL, Traschütz, Andreas, Adarmes Gómez, A. D., Anheim, Mathieu, Baets, Jonathan, Falkenburger, Björn H., Gburek-Augustat, Janina, Doss, Sarah, Kamm, Christoph, Klivenyi, Peter, Grobe-Einsler, Marcus, Klopstock, Thomas, Minnerop, Martina, Münchau, Alexander, Pane, Chiara, Renaud, Mathilde, Santorelli, Filippo M., Schöls, Ludger, Timmann, Dagmar, Vielhaber, Stefan, Haack, Tobias B., Warrenburg, Bart van de, Zanni, Ginevra, Synofzik, Matthis, European Commission, Federal Ministry of Education and Research (Germany), ZonMw, Dutch Research Council, Brain Foundation (The Netherlands), Jacques and Gloria Gossweiler Foundation, Radboud University, University of Tübingen, University of Szeged, Ministry of Innovation and Technology (Hungary), Research Foundation - Flanders, Ministero della Salute, Projekt DEAL, Traschütz, Andreas, Adarmes Gómez, A. D., Anheim, Mathieu, Baets, Jonathan, Falkenburger, Björn H., Gburek-Augustat, Janina, Doss, Sarah, Kamm, Christoph, Klivenyi, Peter, Grobe-Einsler, Marcus, Klopstock, Thomas, Minnerop, Martina, Münchau, Alexander, Pane, Chiara, Renaud, Mathilde, Santorelli, Filippo M., Schöls, Ludger, Timmann, Dagmar, Vielhaber, Stefan, Haack, Tobias B., Warrenburg, Bart van de, Zanni, Ginevra, and Synofzik, Matthis
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- 2023
30. Neuroprotection by Kynurenine Metabolites
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Majláth, Zsófia, Szalárdy, Levente, Zádori, Dénes, Klivényi, Péter, Fülöp, Ferenc, Toldi, József, Vécsei, László, and Kostrzewa, Richard M., editor
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- 2014
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31. Responsiveness of the Scale for the Assessment and Rating of Ataxia and Natural History in 884 Recessive and Early Onset Ataxia Patients.
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Traschütz, Andreas, Adarmes‐Gómez, Astrid D., Anheim, Mathieu, Baets, Jonathan, Brais, Bernard, Gagnon, Cynthia, Gburek‐Augustat, Janina, Doss, Sarah, Hanağası, Haşmet A., Kamm, Christoph, Klivenyi, Peter, Klockgether, Thomas, Klopstock, Thomas, Minnerop, Martina, Münchau, Alexander, Renaud, Mathilde, Santorelli, Filippo M., Schöls, Ludger, Thieme, Andreas, and Vielhaber, Stefan
- Subjects
NATURAL history ,ATAXIA ,HEALTH outcome assessment ,SPINOCEREBELLAR ataxia ,CEREBELLUM degeneration ,ACTIVITIES of daily living - Abstract
Objective: The Scale for the Assessment and Rating of Ataxia (SARA) is the most widely applied clinical outcome assessment (COA) for genetic ataxias, but presents metrological and regulatory challenges. To facilitate trial planning, we characterize its responsiveness (including subitem‐level relations to ataxia severity and patient‐focused outcomes) across a large number of ataxias, and provide first natural history data for several of them. Methods: Subitem‐level correlation and distribution‐based analysis of 1,637 SARA assessments in 884 patients with autosomal recessive/early onset ataxia (370 with 2–8 longitudinal assessments) were complemented by linear mixed effects modeling to estimate progression and sample sizes. Results: Although SARA subitem responsiveness varied between ataxia severities, gait/stance showed a robust granular linear scaling across the broadest range (SARA < 25). Responsiveness was diminished by incomplete subscale use at intermediate or upper levels, nontransitions ("static periods"), and fluctuating decreases/increases. All subitems except nose‐finger showed moderate‐to‐strong correlations to activities of daily living, indicating that metric properties—not content validity—limit SARA responsiveness. SARA captured mild‐to‐moderate progression in many genotypes (eg, SYNE1‐ataxia: 0.55 points/yr, ataxia with oculomotor apraxia type 2: 1.14 points/yr, POLG‐ataxia: 1.56 points/yr), but no change in others (autosomal recessive spastic ataxia of Charlevoix‐Saguenay, COQ8A‐ataxia). Whereas sensitivity to change was optimal in mild ataxia (SARA < 10), it substantially deteriorated in advanced ataxia (SARA > 25; 2.7‐fold sample size). Use of a novel rank‐optimized SARA without subitems finger‐chase and nose‐finger reduces sample sizes by 20 to 25%. Interpretation: This study comprehensively characterizes COA properties and annualized changes of the SARA across and within a large number of ataxias. It suggests specific approaches for optimizing its responsiveness that might facilitate regulatory qualification and trial design. ANN NEUROL 2023;94:470–485 [ABSTRACT FROM AUTHOR]
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- 2023
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32. Comparison of the Outcome of Deep Brain Stimulator Surgeries in Parkinson’s Disease by Using Frame Based and Frameless Stereotactic Systems
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Dancso, Balint, primary, Barzo, Pal, additional, Klivenyi, Peter, additional, Zadori, Denes, additional, Szpisjak, Laszlo, additional, Varga, Adam, additional, Szappanos, Norbert, additional, and Kis, David, additional
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- 2023
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33. Defining the Location of the Stimulation Hot Spot of the Motor Subthalamic Nucleus of Akinetic and Tremor Dominant Parkinson’s Disease Patients
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Jha, Shivangi, primary, Radler, Andrea, additional, Zadori, Denes, additional, Klivenyi, Peter, additional, Kis, David, additional, and Barzo, Pal, additional
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- 2023
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34. Neurocognitive Characterization of an SCA28 Family Caused by a Novel AFG3L2 Gene Mutation
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Szpisjak, Laszlo, Nemeth, Viola L., Szepfalusi, Noemi, Zadori, Denes, Maroti, Zoltan, Kalmar, Tibor, Vecsei, Laszlo, and Klivenyi, Peter
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- 2017
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35. Novel AARS2 gene mutation producing leukodystrophy: a case report
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Szpisjak, Laszlo, Zsindely, Nora, Engelhardt, Jozsef I, Vecsei, Laszlo, Kovacs, Gabor G, and Klivenyi, Peter
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- 2017
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36. Language Deficits in Pre-Symptomatic Huntington's Disease: Evidence from Hungarian
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Nemeth, Dezso, Dye, Cristina D., Sefcsik, Tamas, Janacsek, Karolina, Turi, Zsolt, Londe, Zsuzsa, Klivenyi, Peter, Kincses, Zsigmond Tamas, Szabo, Nikoletta, Vecsei, Laszlo, and Ullman, Michael T.
- Abstract
A limited number of studies have investigated language in Huntington's disease (HD). These have generally reported abnormalities in rule-governed (grammatical) aspects of language, in both syntax and morphology. Several studies of verbal inflectional morphology in English and French have reported evidence of over-active rule processing, such as over-suffixation errors (e.g., walkeded) and over-regularizations (e.g., digged). Here we extend the investigation to noun inflection in Hungarian, a Finno-Ugric agglutinative language with complex morphology, and to genetically proven pre-symptomatic Huntington's disease (pre-HD). Although individuals with pre-HD have no clinical, motor or cognitive symptoms, the underlying pathology may already have begun, and thus sensitive behavioral measures might reveal already-present impairments. Indeed, in a Hungarian morphology production task, pre-HD patients made both over-suffixation and over-regularization errors. The findings suggest the generality of over-active rule processing in both HD and pre-HD, across languages from different families with different morphological systems, and for both verbal and noun inflection. Because the neuropathology in pre-HD appears to be largely restricted to the caudate nucleus and related structures, the findings further implicate these structures in language, and in rule-processing in particular. Finally, the need for effective treatments in HD, which will likely depend in part on the ability to sensitively measure early changes in the disease, suggests the possibility that inflectional morphology, and perhaps other language measures, may provide useful diagnostic, tracking, and therapeutic tools for assessing and treating early degeneration in pre-HD and HD. (Contains 2 tables and 1 figure.)
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- 2012
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37. Kynurenines in Neurodegenerative Disorders: Therapeutic Consideration
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Klivényi, Péter, Toldi, József, Vécsei, László, and Vécsei, László, editor
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- 2004
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38. CSF biomarker variability in the Alzheimer's Association quality control program
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Rojo, Aladro José A., Albert, Marilyn, Alcolea, Daniel, Andreasson, Ulf, Antonell, Anna, Arai, Hiroyuki, Archetti, Silvana, Arkblad, Eva, Baldeiras, Inês, Bartos, Ales, Batish, Dev, Bedel, Aurélie, Bentue-Ferrer, Daniele, Berisha, Flora, Bernardini, Sergio, Blankenstein, Marinus, Blennow, Kaj, Bousiges, Olivier, Camuso, Michael C., Carrillo, Maria, Casoli, Tiziana, Cavallaro, Sebastiano, Chalbot, Sonia, Collins, Steven, Cruz e Silva, Odete, Cutler, Neal, Cuvelier, Isabelle, Delaroche, Odile, Dufour-Rainfray, Diane, Dyer, Roy, Engelborghs, Sebastiaan, Fagan, Anne M., Fogli, Anne, Forlenza, Orestes V., Fox, Nick, Frisoni, Giovanni, Galimberti, Daniela, Galloni, Elisabetta, Gritti, Silvana, Gylys, Karen H., Hampel, Harald, Haustein, Sabine, Heath, Theresa, Heegaard, Niels H.H., Heneka, Michael T., Herukka, Sanna-Kaisa, Holtzman, David, Hsiung, Ging-Yuek Robin, Humpel, Christian, Hyman, Bradley, Iwatsubo, Takeshi, Iqbal, Khalid, Jardel, Claude, Jucker, Mathias, Kapaki, Elisabeth, Käser, Stephan A., Kidd, Daniel, Klivenyi, Peter, Kuwano, Ryozo, Lachno, D. Richard, Lamari, Foudil, Laplanche, Jean-Louis, Laser, Jordan, Lehmann, Sylvian, Lewczuk, Piotr, Li, Qiao-Xin, Lleó, Alberto, Maetzler, Walter, Malaplate-Armand, Catherine, Martin, Ralph, Martone, Robert L., Masters, Colin, Mattsson, Niklas, Mercken, Marc, Molinuevo, José Luis, Montine, Tom, Nowatzke, William, Otto, Markus, Parchi, Piero, Parent, Xavier, Parnetti, Lucilla, Persson, Staffan, Petersen, Ronald, Poesen, Koen, Quadrio, Isabelle, Quillard, Muriel, Regeniter, Axel, Rello, Vara Luis, Rissman, Robert, Rohan, Zdenek, Rosenmann, Hanna, Sancesario, Giuseppe, Schröder, Johannes, Shaw, Leslie M., Sisowath, Christin, Skinningsrud, Anders, Soares, Holly, Soininen, Hilkka, Søndersø, Knudsen Cindy, Spreer, Annette, Suardi, Silvia, Teunissen, Charlotte, Trojanowski, John Q., Umek, Robert, Van Broeck, Bianca, Vandenberghe, Rik, Vanderstichele, Hugo, Vandijck, Manu, Vecsei, Laszlo, Verbeek, Marcel, Vostiar, Igor, Windisch, Manfred, Zetterberg, Henrik, Carrillo, Maria C., Robin Hsiung, Ging-Yuek, Molinuevo, José L., Teunissen, Charlotte E., and Verbeek, Marcel M.
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- 2013
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39. A novel SETX gene mutation producing ataxia with oculomotor apraxia type 2
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Szpisjak, Laszlo, Obal, Izabella, Engelhardt, Jozsef I., Vecsei, Laszlo, and Klivenyi, Peter
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- 2016
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40. Time-course of kynurenic acid concentration in mouse serum following the administration of a novel kynurenic acid analog
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Zádori, Dénes, Ilisz, István, Klivényi, Péter, Szatmári, István, Fülöp, Ferenc, Toldi, József, Vécsei, László, and Péter, Antal
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- 2011
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41. The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers
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Mattsson, Niklas, Andreasson, Ulf, Persson, Staffan, Arai, Hiroyuki, Batish, Sat Dev, Bernardini, Sergio, Bocchio-Chiavetto, Luisella, Blankenstein, Marinus A., Carrillo, Maria C., Chalbot, Sonia, Coart, Els, Chiasserini, Davide, Cutler, Neal, Dahlfors, Gunilla, Duller, Stefan, Fagan, Anne M., Forlenza, Orestes, Frisoni, Giovanni B., Galasko, Douglas, Galimberti, Daniela, Hampel, Harald, Handberg, Aase, Heneka, Michael T., Herskovits, Adrianna Z., Herukka, Sanna-Kaisa, Holtzman, David M., Humpel, Christian, Hyman, Bradley T., Iqbal, Khalid, Jucker, Mathias, Kaeser, Stephan A., Kaiser, Elmar, Kapaki, Elisabeth, Kidd, Daniel, Klivenyi, Peter, Knudsen, Cindy S., Kummer, Markus P., Lui, James, Lladó, Albert, Lewczuk, Piotr, Li, Qiao-Xin, Martins, Ralph, Masters, Colin, McAuliffe, John, Mercken, Marc, Moghekar, Abhay, Molinuevo, José Luis, Montine, Thomas J., Nowatzke, William, O’Brien, Richard, Otto, Markus, Paraskevas, George P., Parnetti, Lucilla, Petersen, Ronald C., Prvulovic, David, de Reus, Herman P.M., Rissman, Robert A., Scarpini, Elio, Stefani, Alessandro, Soininen, Hilkka, Schröder, Johannes, Shaw, Leslie M., Skinningsrud, Anders, Skrogstad, Brith, Spreer, Annette, Talib, Leda, Teunissen, Charlotte, Trojanowski, John Q., Tumani, Hayrettin, Umek, Robert M., Van Broeck, Bianca, Vanderstichele, Hugo, Vecsei, Laszlo, Verbeek, Marcel M., Windisch, Manfred, Zhang, Jing, Zetterberg, Henrik, and Blennow, Kaj
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- 2011
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42. Genetic analysis of the SOD1 and C9ORF72 genes in Hungarian patients with amyotrophic lateral sclerosis
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Tripolszki, Kornélia, Csányi, Bernadett, Nagy, Dóra, Ratti, Antonia, Tiloca, Cinzia, Silani, Vincenzo, Kereszty, Éva, Török, Nóra, Vécsei, László, Engelhardt, József I., Klivényi, Péter, Nagy, Nikoletta, and Széll, Márta
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- 2017
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43. Global Impact of COVID-19 on Stroke Care and IV Thrombolysis
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Nogueira, Raul, Qureshi, Muhammad, Abdalkader, Mohamad, Martins, Sheila Ouriques, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama Yassin, Sathya, Anvitha, Czlonkowska, Anna, Tsivgoulis, Georgios, Aguiar de Sousa, Diana, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Kõrv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine Anne, Turan, Tanya, Ntaios, George, Malhotra, Konark, Tayal, Ashis, Loochtan, Aaron, Ranta, Annamarei, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Mohammaden, Mahmoud, Frankel, Michael, Bila Lamou, Eric Guemekane, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Menecie, Tarek, Mustafa, Wessam, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred, Alabi, Tolulope Oyetunde, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole, Yaria, Joseph, Mohammed, Haytham Hussein, Adebayo, Philip, Riahi, Anis, Sassi, Samia Ben, Gwaunza, Lenon, Ngwende, Gift Wilson, Sahakyan, David, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj Durai, Sylaja, Pn, Usman, Fritz Sumantri, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Horev, Anat, Reznik, Anna, Sivan Hoffmann, Rotem, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Kondybayeva, Aida, Faizullina, Kamila, Kamenova, Saltanat, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Jin Soo, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Sohn, Sung Il, Young, Chang Jun, Ahdab, Rechdi, Wan Zaidi, Wan Asyraf, Aziz, Zariah Abdul, Basri, Hamidon Bin, Chung, Law Wan, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yahia Zakaria, Akhtar, Naveed, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Venketasubramanian, Narayanaswamy, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Akil, Esref, Aykaç, Özlem, Ozdemir, Atilla Ozcan, Giray, Semih, Hussain, Syed Irteza, John, Seby, Le Vu, Huynh, Tran, Anh Duc, Nguyen, Huy Hoang, Nhu Pham, Thong, Nguyen, Thang Huy, Nguyen, Trung Quoc, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, de Blauwe, Sofie, Vanhooren, Geert, de Raedt, Sylvie, Dusart, Anne, Lemmens, Robin, Ligot, Noemie, Pierre Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedeković, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, František, Karpowic, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Daniel, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henryk, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurák, Lubomír, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Krarup Christensen, Hanne, Drenck, Nicolas, Klingenberg Iversen, Helle, Simonsen, Claus, Truelsen, Thomas Clement, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emilie, Ondze, Basile, Peres, Roxane, Pico, Fernando, Piotin, Michel, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nino, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Götz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Klivenyi, Peter, Szapary, Laszlo, Tarkanyi, Gabor, Adami, Alessandro, Bandini, Fabio, Calabresi, Paolo, Frisullo, Giovanni, Renieri, Leonardo, Sangalli, Davide, Pirson, Anne, Uyttenboogaart, Maarten, van den Wijngaard, Ido, Kristoffersen, Espen Saxhaug, Brola, Waldemar, Fudala, Małgorzata, Horoch-Lyszczarek, Ewa, Karlinski, Michal, Kazmierski, Radoslaw, Kram, Pawel, Rogoziewicz, Marcin, Kaczorowski, Rafal, Luchowski, Piotr, Sienkiewicz-Jarosz, Halina, Sobolewski, Piotr, Fryze, Waldemar, Wisniewska, Anna, Wiszniewska, Malgorzata, Ferreira, Patricia, Ferreira, Paulo, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Nunes, Ana Paiva, Rodrigues, Miguel, Tedim Cruz, Vítor, Falup-Pecurariu, Cristian, Krastev, Georgi, Mako, Miroslav, de Leciñana, María Alonso, Arenillas, Juan, Ayo-Martin, Oscar, Cruz Culebras, Antonio, Tejedor, Exuperio Diez, Montaner, Joan, Pérez-Sánchez, Soledad, Tola Arribas, Miguel Angel, Rodriguez Vasquez, Alejandro, Mayza, Michael, Bernava, Gianmarco, Brehm, Alex, Machi, Paolo, Fischer, Urs, Gralla, Jan, Michel, Patrik, Psychogios, Marios-Nikos, Strambo, Davide, Banerjee, Soma, Krishnan, Kailash, Kwan, Joseph, Butt, Asif, Catanese, Luciana, Demchuk, Andrew, Field, Thalia, Haynes, Jennifer, Hill, Michael, Khosravani, Houman, Mackey, Ariane, Pikula, Aleksandra, Saposnik, Gustavo, Scott, Courtney Anne, Shoamanesh, Ashkan, Shuaib, Ashfaq, Yip, Samuel, Barboza, Miguel, Barrientos, Jose Domingo, Portillo Rivera, Ligia Ibeth, Gongora-Rivera, Fernando, Novarro-Escudero, Nelson, Blanco, Anmylene, Abraham, Michael, Alsbrook, Diana, Altschul, Dorothea, Alvarado-Ortiz, Anthony, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Brereton, Charmaine, Castonguay, Alicia, Chaturvedi, Seemant, Chaudry, Saqib, Choe, Hana, Choi, Jae, Dharmadhikari, Sushrut, Desai, Kinjal, Devlin, Thomas, Doss, Vinodh, Edgell, Randall, Etherton, Mark, Farooqui, Mudassir, Frei, Don, Gandhi, Dheeraj, Grigoryan, Mikayel, Gupta, Rishi, Hassan, Ameer, Helenius, Johanna, Kaliaev, Artem, Kaushal, Ritesh, Khandelwal, Priyank, Khawaja, Ayaz, Khoury, Naim, Kim, Benny, Kleindorfer, Dawn, Koyfman, Feliks, Lee, Vivien, Leung, Lester, Linares, Guillermo, Linfante, Italo, Lutsep, Helmi, Macdougall, Lisa, Male, Shailesh, Malik, Amer, Masoud, Hesham, Mcdermott, Molly, Mehta, Brijesh, Min, Jiangyong, Mittal, Manoj, Morris, Jane, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Nguyen, Claude, Novakovic-White, Roberta, Ortega-Gutierrez, Santiago, Rahangdale, Rahul, Ramakrishnan, Pankajavalli, Romero, Jose Rafael, Rost, Natalia, Rothstein, Aaron, Ruland, Sean, Shah, Ruchir, Sharma, Malveeka, Silver, Brian, Simmons, Marc, Singh, Abhishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Voetsch, Barbara, Balaguera, Oscar, Pujol Lereis, Virginia, Luraschi, Adriana, Almeida, Marcele Schettini, Cardoso, Fabricio Buchdid, Conforto, Adriana, de Deus Silva, Leonardo, Varrone Giacomini, Luidia, Oliveira Lima, Fabricio, Longo, Alexandre, Magalhães, Pedro, Martins, Rodrigo Targa, Mont'Alverne, Francisco, Mora Cuervo, Daissy Liliana, Costa Rebello, Leticia, Valler, Lenise, Zetola, Viviane Flumignan, Lavados, Pablo, Navia, Victor, Olavarría, Verónica, Almeida Toro, Juan Manuel, Amaya, Pablo Felipe Ricardo, Bayona, Hernan, Corredor, Angel, Rivera Ordonez, Carlos Eduardo, Mantilla Barbosa, Diana Katherine, Lara, Osvaldo, Patiño, Mauricio, Diaz Escobar, Luis Fernando, Dejesus Melgarejo Fariña, Donoband Edson, Cardozo Villamayor, Analia, Zelaya Zarza, Adolfo Javier, Barrientos Iman, Danny Moises, Rodriguez Kadota, Liliana, Campbell, Bruce, Hankey, Graeme, Hair, Casey, Kleinig, Timothy, Ma, Alice, Tomazini Martins, Rodrigo, Sahathevan, Ramesh, Thijs, Vincent, Salazar, Daniel, Yuan-Hao Wu, Teddy, Haussen, Diogo, Liebeskind, David, Yavagal, Dileep, Jovin, Tudor, Zaidat, Osama, Nguyen, Thanh, Magalhães, Pedro S.C., Emory University School of Medicine, Emory University [Atlanta, GA], Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Max Super Speciality Hospital -Saket [New Delhi, Inde] (Max Saket), Dupuis, Christine, Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), and Repositório da Universidade de Lisboa
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medicine.medical_specialty ,MESH: Pandemics ,HSJ NEU ,Cross-sectional study ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,SVIN COVID-19 Global Stroke Registry ,MESH: Hospitalization ,030204 cardiovascular system & hematology ,Article ,MESH: Stroke ,COVID-19 ,cross-sectional studies ,hospitalization ,humans ,pandemics ,retrospective studies ,SARS-CoV-2 ,stroke ,03 medical and health sciences ,0302 clinical medicine ,MESH: Cross-Sectional Studies ,Pandemic ,Medicine ,Humans ,MESH: COVID-19 ,Thrombolytic Therapy ,MESH: SARS-CoV-2 ,Stroke ,Pandemics ,Retrospective Studies ,MESH: Thrombolytic Therapy ,Rehabilitation ,MESH: Humans ,business.industry ,Retrospective cohort study ,MESH: Retrospective Studies ,medicine.disease ,Thrombolysis ,Confidence interval ,3. Good health ,Hospitalization ,[SDV] Life Sciences [q-bio] ,Clinical research ,Cross-Sectional Studies ,Emergency medicine ,Observational study ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
© 2021 American Academy of Neurology, Objective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3, p < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95% CI -13.8 to -12.7, p < 0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95% CI -13.7 to -10.3, p = 0.001). Recovery of stroke hospitalization volume (9.5%, 95% CI 9.2-9.8, p < 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. Conclusions: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.
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44. Editorial: Antiplatelet Agents in Stroke Prevention
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Feher, Gergely, primary, Hargroves, David, additional, Illes, Zsolt, additional, Klivenyi, Peter, additional, Liu, Liping, additional, and Szapary, Laszlo, additional
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- 2021
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45. LRRK2 mutations in Parkinson's disease patients from Central Europe: A case control study
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Sendekova, Daniela, Cobejova, Jana, Cobej, Martin, Sukovska, Viktoria, Pálvölgyi, Károlyné, Kovacs, Norbert, Pintér, David, Ruzicka, Evzen, Holly, Petr, Dusek, Petr, Starkova, Irena, Brdkova, Jana, Smilowska, Katarzyna, Falup-Pecurariu, Cristian, Diaconu, Stefania, Klivenyi, Peter, Balaz, Marek, Skorvanek, Matej, Rizig, Mie, Athanasiou-Fragkouli, Alkyoni, Necpal, Jan, Straka, Igor, Tamas, Gertrud, Kurca, Egon, Mosejova, Alexandra, Han, Vladimir, Lorincova, Tatiana, Ostrozovicova, Miriam, Liesenerova, Simona, Levicka, Petra, Fajcikova, Lucia, Minar, Michal, Valkovic, Peter, Mákos, Orsolya, Kelemen, Andrea, Grofik, Milan, Cibulka, Michal, Jama, Fatumah, and Houlden, Henry
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- 2021
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46. Neuroimaging and cognitive changes during déjà vu
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Kovacs, Norbert, Auer, Tibor, Balas, Istvan, Karadi, Kazmer, Zambo, Katalin, Schwarcz, Attila, Klivenyi, Peter, Jokeit, Hennric, Horvath, Krisztina, Nagy, Ferenc, and Janszky, Jozsef
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- 2009
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47. The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection
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Vamos, Eniko, Pardutz, Arpad, Klivenyi, Peter, Toldi, Jozsef, and Vecsei, Laszlo
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48. Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis
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Nogueira, Raul G, Qureshi, Muhammed M, Abdalkader, Mohamad, Martins, Sheila Ouriques, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama Yassin, Sathya, Anvitha, Czlonkowska, Anna, Tsivgoulis, Georgios, Aguiar de Sousa, Diana, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James E, Kõrv, Janika, Biller, Jose, Liang, Conrad W, Sangha, Navdeep S, Zha, Alicia M, Czap, Alexandra L, Holmstedt, Christine Anne, Turan, Tanya N, Ntaios, George, Malhotra, Konark, Tayal, Ashis, Loochtan, Aaron, Ranta, Annamarei, Mistry, Eva A, Alexandrov, Anne W, Huang, David Y, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil A, Mohammaden, Mahmoud H, Frankel, Michael, Bila Lamou, Eric Guemekane, Aref, Hany M, Elbassiouny, Ahmed, Hassan, Farouk, Menecie, Tarek, Mustafa, Wessam, Shokri, Hossam M, Roushdy, Tamer, Sarfo, Fred S, Alabi, Tolulope Oyetunde, Arabambi, Babawale, Nwazor, Ernest O, Sunmonu, Taofiki Ajao, Wahab, Kolawole, Yaria, Joseph, Mohammed, Haytham Hussein, Adebayo, Philip B, Riahi, Anis D, Ben Sassi, Samia, Gwaunza, Lenon, Ngwende, Gift Wilson, Sahakyan, David, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas W, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj Durai, Sylaja, P N, Usman, Fritz Sumantri, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Horev, Anat, Reznik, Anna, Hoffmann, Rotem Sivan, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Kondybayeva, Aida, Faizullina, Kamila, Kamenova, Saltanat, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Jin Soo, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Sohn, Sung Il, Young, Chang Jun, Ahdab, Rechdi, Wan Zaidi, Wan Asyraf, Aziz, Zariah Abdul, Basri, Hamidon Bin, Chung, Law Wan, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal M, Imam, Yahia Zakaria, Akhtar, Naveed, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Venketasubramanian, Narayanaswamy, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Akil, Esref, Aykaç, Ozlem, Ozdemir, Atilla Ozcan, Giray, Semih, Hussain, Syed Irteza, John, Seby, Le Vu, Huynh, Tran, Anh Duc, Nguyen, Huy Hoang, Pham, Thong Nhu, Nguyen, Thang Huy, Nguyen, Trung Quoc, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Vanhooren, Geert, De Raedt, Sylvie, Dusart, Anne, Lemmens, Robin, Ligot, Noemie, Rutgers, Matthieu Pierre, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedeković, Marina Roje, Budincevic, Hrvoje, Cindrić, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantiek, Karpowic, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Daniel, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henryk, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurák, Lubomír, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle Klingenberg, Simonsen, Claus Z, Truelsen, Thomas Clement, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emilie, Ondze, Basile, Peres, Roxane, Pico, Fernando, Piotin, Michel, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nino, Tsikaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Götz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Klivenyi, Peter, Szapary, Laszlo, Tarkanyi, Gabor, Adami, Alessandro, Bandini, Fabio, Calabresi, Paolo, Frisullo, Giovanni, Renieri, Leonardo, Sangalli, Davide, Pirson, Anne V, Uyttenboogaart, Maarten, van den Wijngaard, Ido, Kristoffersen, Espen Saxhaug, Brola, Waldemar, Fudala, Małgorzata, Horoch-Lyszczarek, Ewa, Karlinski, Michal, Kazmierski, Radoslaw, Kram, Pawel, Rogoziewicz, Marcin, Kaczorowski, Rafal, Luchowski, Piotr, Sienkiewicz-Jarosz, Halina, Sobolewski, Piotr, Fryze, Waldemar, Wisniewska, Anna, Wiszniewska, Malgorzata, Ferreira, Patricia, Ferreira, Paulo, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Nunes, Ana Paiva, Rodrigues, Miguel, Cruz, Vítor Tedim, Falup-Pecurariu, Cristian, Krastev, Georgi, Mako, Miroslav, Alonso de Leciñana, María, Arenillas, Juan F, Ayo-Martin, Oscar, Culebras, Antonio Cruz, Tejedor, Exuperio Diez, Montaner, Joan, Pérez-Sánchez, Soledad, Tola Arribas, Miguel Angel, Vasquez, Alejandro Rodriguez, Mazya, Michael, Bernava, Gianmarco, Brehm, Alex, Machi, Paolo, Fischer, Urs, Gralla, Jan, Michel, Patrik L, Psychogios, Marios-Nikos, Strambo, Davide, Banerjee, Soma, Krishnan, Kailash, Kwan, Joseph, Butt, Asif, Catanese, Luciana, Demchuk, Andrew, Field, Thalia, Haynes, Jennifer, Hill, Michael D, Khosravani, Houman, Mackey, Ariane, Pikula, Aleksandra, Saposnik, Gustavo, Scott, Courtney Anne, Shoamanesh, Ashkan, Shuaib, Ashfaq, Yip, Samuel, Barboza, Miguel A, Barrientos, Jose Domingo, Portillo Rivera, Ligia Ibeth, Gongora-Rivera, Fernando, Novarro-Escudero, Nelson, Blanco, Anmylene, Abraham, Michael, Alsbrook, Diana, Altschul, Dorothea, Alvarado-Ortiz, Anthony J, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Brereton, Charmaine, Castonguay, Alicia, Chaturvedi, Seemant, Chaudhry, Saqib A, Choe, Hana, Choi, Jae H, Dharmadhikari, Sushrut, Desai, Kinjal, Devlin, Thomas G, Doss, Vinodh T, Edgell, Randall, Etherton, Mark, Farooqui, Mudassir, Frei, Don, Gandhi, Dheeraj, Grigoryan, Mikayel, Gupta, Rishi, Hassan, Ameer E, Helenius, Johanna, Kaliaev, Artem, Kaushal, Ritesh, Khandelwal, Priyank, Khawaja, Ayaz M, Khoury, Naim N, Kim, Benny S, Kleindorfer, Dawn O, Koyfman, Feliks, Lee, Vivien H, Leung, Lester Y, Linares, Guillermo, Linfante, Italo, Lutsep, Helmi L, Macdougall, Lisa, Male, Shailesh, Malik, Amer, Masoud, Hesham, McDermott, Molly, Mehta, Brijesh P, Min, Jiangyong, Mittal, Manoj, Morris, Jane G, Multani, Sumeet S, Nahab, Fadi, Nalleballe, Krishna, Nguyen, Claude B, Novakovic-White, Roberta, Ortega-Gutierrez, Santiago, Rahangdale, Rahul H, Ramakrishnan, Pankajavalli, Romero, Jose Rafael, Rost, Natalia, Rothstein, Aaron, Ruland, Sean, Shah, Ruchir, Sharma, Malveeka, Silver, Brian, Simmons, Marc, Singh, Abhishek, Starosciak, Amy K, Strasser, Sheryl L, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny P, Voetsch, Barbara, Balaguera, Oscar, Pujol Lereis, Virginia A, Luraschi, Adriana, Almeida, Marcele Schettini, Cardoso, Fabricio Buchdid, Conforto, Adriana, De Deus Silva, Leonardo, Giacomini, Luidia Varrone, Lima, Fabricio Oliveira, Longo, Alexandre L, Magalhães, Pedro Sc, Martins, Rodrigo Targa, Mont'alverne, Francisco, Mora Cuervo, Daissy Liliana, Rebello, Leticia Costa, Valler, Lenise, Zetola, Viviane Flumignan, Lavados, Pablo M, Navia, Victor, Olavarría, Verónica V, Almeida Toro, Juan Manuel, Ricardo Amaya, Pablo Felipe, Bayona, Hernan, Corredor-Quintero, Angel Basilio, Rivera Ordonez, Carlos Eduardo, Mantilla Barbosa, Diana Katherine, Lara, Osvaldo, Patiño, Mauricio R, Diaz Escobar, Luis Fernando, Dejesus Melgarejo Farina, Donoband Edson, Villamayor, Analia Cardozo, Zelaya Zarza, Adolfo Javier, Barrientos Iman, Danny Moises, Kadota, Liliana Rodriguez, Campbell, Bruce, Hankey, Graeme J, Hair, Casey, Kleinig, Timothy, Ma, Alice, Martins, Rodrigo Tomazini, Sahathevan, Ramesh, Thijs, Vincent, Salazar, Daniel, Yuan-Hao Wu, Teddy, Haussen, Diogo C, Liebeskind, David, Yavagal, Dileep, Jovin, Tudor G, Zaidat, Osama O, and Nguyen, Thanh N
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610 Medicine & health - Abstract
OBJECTIVE The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. METHODS We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases. RESULTS There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p
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49. The ARCA Registry: a collaborative global platform for advancing trial readiness in autosomal recessive cerebellar ataxias
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Başak, Ayşe Nazlı (ORCID 0000-0001-9257-3540 & YÖK ID 1512), Traschuetz, Andreas; Reich, Selina; Adarmes, Astrid D.; Anheim, Mathieu; Ashrafi, Mahmoud Reza; Baets, Jonathan; Bertini, Enrico; Brais, Bernard; Gagnon, Cynthia; Gburek-Augustat, Janina; Hanagasi, Hasmet A.; Heinzmann, Anna; Horvath, Rita; de Jonghe, Peter; Kamm, Christoph; Klivenyi, Peter; Klopstock, Thomas; Minnerop, Martina; Muenchau, Alexander; Renaud, Mathilde; Roxburgh, Richard H.; Santorelli, Filippo M.; Schirinzi, Tommaso; Sival, Deborah A.; Timmann, Dagmar; Vielhaber, Stefan; Wallner, Michael; van de Warrenburg, Bart P.; Zanni, Ginevra; Zuchner, Stephan; Klockgether, Thomas; Schuele, Rebecca; Schols, Ludger; Synofzik, Matthis, Başak, Ayşe Nazlı (ORCID 0000-0001-9257-3540 & YÖK ID 1512), and Traschuetz, Andreas; Reich, Selina; Adarmes, Astrid D.; Anheim, Mathieu; Ashrafi, Mahmoud Reza; Baets, Jonathan; Bertini, Enrico; Brais, Bernard; Gagnon, Cynthia; Gburek-Augustat, Janina; Hanagasi, Hasmet A.; Heinzmann, Anna; Horvath, Rita; de Jonghe, Peter; Kamm, Christoph; Klivenyi, Peter; Klopstock, Thomas; Minnerop, Martina; Muenchau, Alexander; Renaud, Mathilde; Roxburgh, Richard H.; Santorelli, Filippo M.; Schirinzi, Tommaso; Sival, Deborah A.; Timmann, Dagmar; Vielhaber, Stefan; Wallner, Michael; van de Warrenburg, Bart P.; Zanni, Ginevra; Zuchner, Stephan; Klockgether, Thomas; Schuele, Rebecca; Schols, Ludger; Synofzik, Matthis
- Abstract
Autosomal recessive cerebellar ataxias (ARCAs) form an ultrarare yet expanding group of neurodegenerative multisystemic diseases affecting the cerebellum and other neurological or non-neurological systems. With the advent of targeted therapies for ARCAs, disease registries have become a precious source of real-world quantitative and qualitative data complementing knowledge from preclinical studies and clinical trials. Here, we review the ARCA Registry, a global collaborative multicenter platform (>15 countries, >30 sites) with the overarching goal to advance trial readiness in ARCAs. It presents a good clinical practice (GCP)- and general data protection regulation (GDPR)-compliant professional-reported registry for multicenter web-based capture of cross-center standardized longitudinal data. Modular electronic case report forms (eCRFs) with core, extended, and optional datasets allow data capture tailored to the participating site's variable interests and resources. The eCRFs cover all key data elements required by regulatory authorities [European Medicines Agency (EMA)] and the European Rare Disease (ERD) platform. They capture genotype, phenotype, and progression and include demographic data, biomarkers, comorbidity, medication, magnetic resonance imaging (MRI), and longitudinal clinician- or patient-reported ratings of ataxia severity, non-ataxia features, disease stage, activities of daily living, and (mental) health status. Moreover, they are aligned to major autosomal-dominant spinocerebellar ataxia (SCA) and sporadic ataxia (SPORTAX) registries in the field, thus allowing for joint and comparative analyses not only across ARCAs but also with SCAs and sporadic ataxias. The registry is at the core of a systematic multi-component ARCA database cluster with a linked biobank and an evolving study database for digital outcome measures. Currently, the registry contains more than 800 patients with almost 1,500 visits representing all ages and disease stages; 65% of
- Published
- 2021
50. Neuronal and glial CSF biomarkers in multiple sclerosis : a systematic review and meta-analysis
- Author
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Momtazmanesh, Sara, Shobeiri, Parnian, Saghazadeh, Amene, Teunissen, Charlotte E., Burman, Joachim, Szalardy, Levente, Klivenyi, Peter, Bartos, Ales, Fernandes, Adelaide, Rezaei, Nima, Momtazmanesh, Sara, Shobeiri, Parnian, Saghazadeh, Amene, Teunissen, Charlotte E., Burman, Joachim, Szalardy, Levente, Klivenyi, Peter, Bartos, Ales, Fernandes, Adelaide, and Rezaei, Nima
- Abstract
Multiple sclerosis (MS) is a neurodegenerative disease associated with inflammatory demyelination and astroglial activation, with neuronal and axonal damage as the leading factors of disability. We aimed to perform a meta-analysis to determine changes in CSF levels of neuronal and glial biomarkers, including neurofilament light chain (NFL), total tau (t-tau), chitinase-3-like protein 1 (CHI3L1), glial fibrillary acidic protein (GFAP), and S100B in various groups of MS (MS versus controls, clinically isolated syndrome (CIS) versus controls, CIS versus MS, relapsing-remitting MS (RRMS) versus progressive MS (PMS), and MS in relapse versus remission. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, we included 64 articles in the metaanalysis, including 4071 subjects. For investigation of sources of heterogeneity, subgroup analysis, metaregression, and sensitivity analysis were conducted. Meta-analyses were performed for comparisons including at least three individual datasets. NFL, GFAP, t-tau, CHI3L1, and S100B were higher in MS and NFL, t-tau, and CHI3L1 were also elevated in CIS patients than controls. CHI3L1 was the only marker with higher levels in MS than CIS. GFAP levels were higher in PMS versus RRMS, and NFL, t-tau, and CHI3L1 did not differ between different subtypes. Only levels of NFL were higher in patients in relapse than remission. Meta-regression showed influence of sex and disease severity on NFL and t-tau levels, respectively and disease duration on both. Added to the role of these biomarkers in determining prognosis and treatment response, to conclude, they may serve in diagnosis of MS and distinguishing different subtypes.
- Published
- 2021
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