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197 results on '"Kleive, Dyre"'

4. Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trial

Author

Alseidi, Adnan, Aquilano, Constanza, Arola, Johanna, Bianchi, Denise, Brown, Rachel, Campani, Daniela, ChinAleong, Joanne, Cros, Jerome, Dimitrova, Lyubomira, Doglioni, Claudio, Dokmak, Safi, Dorer, Russell, Doukas, Michael, Fabre, Jean Michel, Ferrari, Giovanni, Grinevich, Viacheslay, Gobbo, Stefano, Hackert, Thilo, van den Heuvel, Marius, Huijsentruijt, Clement, Iglesias, Mar, Jansen, Casper, Khatkov, Igor, Kooby, David, Lena, Marco, Luchini, Claudio, Menon, Krishna, Michenet, Patrick, Molenaar, Quintus, Nedkova, Anna, Pietrabissa, Andrea, Raicu, Mihaela, Rajak, Rushda, Rankovic, Branislava, Rendek, Aniko, Riviere, Benjamin, Cunha, Antonio Sa, Marc, Olivier Saint, Velazquez, Patricia Sanchez, Santini, Donatella, Scarpa, Aldo, Sebagh, Mylene, Sears, Donald, Shah, Mihir, Soonawalla, Zahir, Spaggiari, Paola, Tharun, Lars, Tholfsen, Tore, Tomazic, Ales, Vanoli, Alessandro, Verbeke, Caroline, Verheij, Joanne, Von Winterfeld, Moritz, de Wilde, Roeland, Yip, Vincent, Zen, Yoh, Korrel, Maarten, Jones, Leia R., van Hilst, Jony, Balzano, Gianpaolo, Björnsson, Bergthor, Boggi, Ugo, Bratlie, Svein Olav, Busch, Olivier R., Butturini, Giovanni, Capretti, Giovanni, Casadei, Riccardo, Edwin, Bjørn, Emmen, Anouk M.L.H., Esposito, Alessandro, Falconi, Massimo, Groot Koerkamp, Bas, Keck, Tobias, de Kleine, Ruben H.J., Kleive, Dyre B., Kokkola, Arto, Lips, Daan J., Lof, Sanne, Luyer, Misha D.P., Manzoni, Alberto, Marudanayagam, Ravi, de Pastena, Matteo, Pecorelli, Nicolò, Primrose, John N., Ricci, Claudio, Salvia, Roberto, Sandström, Per, Vissers, Frederique L.I.M., Wellner, Ulrich F., Zerbi, Alessandro, Dijkgraaf, Marcel G.W., Besselink, Marc G., and Abu Hilal, Mohammad

Published
2023
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14. Blood Flow Restriction Exercise in the Perioperative Setting to Prevent Loss of Muscle Mass in Patients with Pancreatic, Biliary Tract, and Liver Cancer: Study protocol for the PREV-Ex Randomized Controlled Trial

Author

Anandavadivelan, Poorna, primary, Cardinale, Daniele, additional, Blomhoff, Rune, additional, Sunde, Berit, additional, Lassen, Kristoffer, additional, Kleive, Dyre, additional, Sturesson, Christian, additional, Gilg, Stefan, additional, Raastad, Truls, additional, and Mijwel, Sara, additional

Published
2024
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16. Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus

Author

van Ramshorst, Tess M E, primary, van Hilst, Jony, additional, Boggi, Ugo, additional, Dokmak, Safi, additional, Edwin, Bjørn, additional, Keck, Tobias, additional, Khatkov, Igor, additional, Balduzzi, Alberto, additional, Pulvirenti, Alessandra, additional, Ahmad, Jawad, additional, Al Saati, Hani, additional, Alseidi, Adnan, additional, Ausania, Fabio, additional, Azagra, Juan S, additional, Balzano, Gianpaolo, additional, Björnsson, Bergthor, additional, Can, Fatih M, additional, Cillo, Umberto, additional, D’Hondt, Mathieu, additional, Efanov, Mikhail, additional, Erkan, Mert, additional, Espin Alvarez, Francisco, additional, Esposito, Alessandro, additional, Ferrari, Giovanni, additional, Groot Koerkamp, Bas, additional, Gumbs, Andrew A, additional, Hogg, Melissa E, additional, Ielpo, Benedetto, additional, Ivanecz, Arpad, additional, Jang, Jin-Young, additional, Kleive, Dyre, additional, Kooby, David A, additional, Luyer, Misha D P, additional, Marchegiani, Giovanni, additional, Menon, Krishna, additional, Molenaar, I Quintus, additional, Nagakawa, Yuichi, additional, Nakamura, Masafumi, additional, Palumbo, Diego, additional, Piardi, Tullio, additional, Ramia, Jose M, additional, Saint-Marc, Olivier, additional, Salti, George I, additional, Strobel, Oliver, additional, Vollmer, Charles M, additional, Wei, Alice C, additional, White, Steve, additional, Yoon, Yoo-Seok, additional, Zerbi, Alessandro, additional, Bassi, Claudio, additional, Berrevoet, Frederik, additional, Chan, Carlos, additional, Coimbra, Felipe J, additional, Conlon, Kevin C P, additional, Dervenis, Christos, additional, Falconi, Massimo, additional, Frigerio, Isabella, additional, Fusai, Giuseppe K, additional, De Oliveira, Michelle L, additional, Pinna, Antonio D, additional, Primrose, John N, additional, Sauvanet, Alain, additional, Serrablo, Alejandro, additional, Smadi, Sameer, additional, Alfieri, Sergio, additional, Berti, Stefano, additional, Butturini, Giovanni, additional, Casadei, Riccardo, additional, Coppola, Roberto, additional, Di Benedetto, Fabrizio, additional, Ettorre, Giuseppe M, additional, Giuliante, Felice, additional, Jovine, Elio, additional, Memeo, Riccardo, additional, Pietrabissa, Andrea, additional, Portolani, Nazario, additional, Salvia, Roberto, additional, Siriwardena, Ajith K, additional, Asbun, Horacio J, additional, Besselink, Marc G, additional, and Abu Hilal, Mohammad, additional

Published
2024
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18. Minimally invasive robot-assisted and laparoscopic distal pancreatectomy in a pan-European registry a retrospective cohort study

Author

MS CGO, Cancer, van Bodegraven, Eduard A., van Ramshorst, Tess M.E., Bratlie, Svein O., Kokkola, Arto, Sparrelid, Ernesto, Björnsson, Bergthor, Kleive, Dyre, Burgdorf, Stefan K., Dokmak, Safi, Groot Koerkamp, Bas, Cabús, Santiago Sánchez, Molenaar, I. Quintus, Boggi, Ugo, Busch, Olivier R., Petrič, Miha, Roeyen, Geert, Hackert, Thilo, Lips, Daan J., D'Hondt, Mathieu, Coolsen, Mariëlle M.E., Ferrari, Giovanni, Tingstedt, Bobby, Serrablo, Alejandro, Gaujoux, Sebastien, Ramera, Marco, Khatkov, Igor, Ausania, Fabio, Souche, Regis, Festen, Sebastiaan, Berrevoet, Frederik, Keck, Tobias, Sutcliffe, Robert P., Pando, Elizabeth, de Wilde, Roeland F., Aussilhou, Beatrice, Krohn, Paul S., Edwin, Bjørn, Sandström, Per, Gilg, Stefan, Seppänen, Hanna, Vilhav, Caroline, Abu Hilal, Mohammad, Besselink, Marc G., European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS), MS CGO, Cancer, van Bodegraven, Eduard A., van Ramshorst, Tess M.E., Bratlie, Svein O., Kokkola, Arto, Sparrelid, Ernesto, Björnsson, Bergthor, Kleive, Dyre, Burgdorf, Stefan K., Dokmak, Safi, Groot Koerkamp, Bas, Cabús, Santiago Sánchez, Molenaar, I. Quintus, Boggi, Ugo, Busch, Olivier R., Petrič, Miha, Roeyen, Geert, Hackert, Thilo, Lips, Daan J., D'Hondt, Mathieu, Coolsen, Mariëlle M.E., Ferrari, Giovanni, Tingstedt, Bobby, Serrablo, Alejandro, Gaujoux, Sebastien, Ramera, Marco, Khatkov, Igor, Ausania, Fabio, Souche, Regis, Festen, Sebastiaan, Berrevoet, Frederik, Keck, Tobias, Sutcliffe, Robert P., Pando, Elizabeth, de Wilde, Roeland F., Aussilhou, Beatrice, Krohn, Paul S., Edwin, Bjørn, Sandström, Per, Gilg, Stefan, Seppänen, Hanna, Vilhav, Caroline, Abu Hilal, Mohammad, Besselink, Marc G., and European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)

Published
2024

19. Pathological complete response in patients with resected pancreatic adenocarcinoma after preoperative chemotherapy

Author

Stoop, Thomas F., Oba, Atsushi, Wu, Y H Andrew, Beaty, Laurel E., Colborn, Kathryn L., Janssen, Boris V., Al-Musawi, Mohammed H., Franco, Salvador Rodriguez, Sugawara, Toshitaka, Franklin, Oskar, Jain, Ajay, Saiura, Akio, Sauvanet, Alain, Coppola, Alessandro, Javed, Ammar A., Groot Koerkamp, Bas, Miller, Braden N., Mack, Claudia E., Hashimoto, Daisuke, Caputo, Damiano, Kleive, Dyre, Sereni, Elisabetta, Belfiori, Giulio, Ichida, Hirofumi, van Dam, Jacob L., Dembinski, Jeanne, Akahoshi, Keiichi, Roberts, Keith J., Tanaka, Kimitaka, Labori, Knut J., Falconi, Massimo, House, Michael G., Sugimoto, Motokazu, Tanabe, Minoru, Gotohda, Naoto, Krohn, Paul S., Burkhart, Richard A., Thakkar, Rohan G., Pande, Rupaly, Dokmak, Safi, Hirano, Satoshi, Burgdorf, Stefan K., Crippa, Stefano, van Roessel, Stijn, Satoi, Sohei, White, Steven A., Hackert, Thilo, Nguyen, Trang K., Yamamoto, Tomohisa, Nakamura, Toru, Bachu, Vismaya, Burns, William R., Inoue, Yosuke, Takahashi, Yu, Ushida, Yuta, Aslami, Zohra V., Verbeke, Caroline S., Fariña, Arantza, He, Jin, Wilmink, Johanna W., Messersmith, Wells, Verheij, Joanne, Kaplan, Jeffrey, Schulick, Richard D., Besselink, Marc G., Del Chiaro, Marco, Stoop, Thomas F., Oba, Atsushi, Wu, Y H Andrew, Beaty, Laurel E., Colborn, Kathryn L., Janssen, Boris V., Al-Musawi, Mohammed H., Franco, Salvador Rodriguez, Sugawara, Toshitaka, Franklin, Oskar, Jain, Ajay, Saiura, Akio, Sauvanet, Alain, Coppola, Alessandro, Javed, Ammar A., Groot Koerkamp, Bas, Miller, Braden N., Mack, Claudia E., Hashimoto, Daisuke, Caputo, Damiano, Kleive, Dyre, Sereni, Elisabetta, Belfiori, Giulio, Ichida, Hirofumi, van Dam, Jacob L., Dembinski, Jeanne, Akahoshi, Keiichi, Roberts, Keith J., Tanaka, Kimitaka, Labori, Knut J., Falconi, Massimo, House, Michael G., Sugimoto, Motokazu, Tanabe, Minoru, Gotohda, Naoto, Krohn, Paul S., Burkhart, Richard A., Thakkar, Rohan G., Pande, Rupaly, Dokmak, Safi, Hirano, Satoshi, Burgdorf, Stefan K., Crippa, Stefano, van Roessel, Stijn, Satoi, Sohei, White, Steven A., Hackert, Thilo, Nguyen, Trang K., Yamamoto, Tomohisa, Nakamura, Toru, Bachu, Vismaya, Burns, William R., Inoue, Yosuke, Takahashi, Yu, Ushida, Yuta, Aslami, Zohra V., Verbeke, Caroline S., Fariña, Arantza, He, Jin, Wilmink, Johanna W., Messersmith, Wells, Verheij, Joanne, Kaplan, Jeffrey, Schulick, Richard D., Besselink, Marc G., and Del Chiaro, Marco

Abstract

Importance: Preoperative chemo(radio)therapy is increasingly used in patients with localized pancreatic adenocarcinoma, leading to pathological complete response (pCR) in a small subset of patients. However, multicenter studies with in-depth data about pCR are lacking. Objective: To investigate the incidence, outcome, and risk factors of pCR after preoperative chemo(radio)therapy. Design, Setting, and Participants: This observational, international, multicenter cohort study assessed all consecutive patients with pathology-proven localized pancreatic adenocarcinoma who underwent resection after 2 or more cycles of chemotherapy (with or without radiotherapy) in 19 centers from 8 countries (January 1, 2010, to December 31, 2018). Data collection was performed from February 1, 2020, to April 30, 2022, and analyses from January 1, 2022, to December 31, 2023. Median follow-up was 19 months. Exposures: Preoperative chemotherapy (with or without radiotherapy) followed by resection. Main Outcomes and Measures: The incidence of pCR (defined as absence of vital tumor cells in the sampled pancreas specimen after resection), its association with OS from surgery, and factors associated with pCR. Factors associated with overall survival (OS) and pCR were investigated with Cox proportional hazards and logistic regression models, respectively. Results: Overall, 1758 patients (mean [SD] age, 64 [9] years; 879 [50.0%] male) were studied. The rate of pCR was 4.8% (n = 85), and pCR was associated with OS (hazard ratio, 0.46; 95% CI, 0.26-0.83). The 1-, 3-, and 5-year OS rates were 95%, 82%, and 63% in patients with pCR vs 80%, 46%, and 30% in patients without pCR, respectively (P < .001). Factors associated with pCR included preoperative multiagent chemotherapy other than (m)FOLFIRINOX ([modified] leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin) (odds ratio [OR], 0.48; 95% CI, 0.26-0.87), preoperative conventional radiotherapy (OR, 2.03; 95%

Published
2024
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20. Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus

Author

MS CGO, Cancer, van Ramshorst, Tess M.E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Saati, Hani Al, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D’Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Alvarez, Francisco Espin, Esposito, Alessandro, Ferrari, Giovanni, Koerkamp, Bas Groot, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D.P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I., Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Benedetto, Fabrizio Di, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., Hilal, Mohammad Abu, MS CGO, Cancer, van Ramshorst, Tess M.E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Saati, Hani Al, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D’Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Alvarez, Francisco Espin, Esposito, Alessandro, Ferrari, Giovanni, Koerkamp, Bas Groot, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D.P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I., Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Benedetto, Fabrizio Di, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., and Hilal, Mohammad Abu

Published
2024

21. Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus

Author

van Ramshorst, Tess M. E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjorn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D'Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin-Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D. P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I, Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo-Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C. P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., Abu Hilal, Mohammad, van Ramshorst, Tess M. E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjorn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D'Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin-Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D. P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I, Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo-Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C. P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., and Abu Hilal, Mohammad

Abstract

Funding Agencies|Intuitive grant for the LEARNBOT European Robotic Pancreatoduodenectomy training programme; DIPLOMA-2 trial; E-MIPS Registry; Medtronic grant for the investigator-initiated DIPLOMA trial; Ethicon grant for the PANDORINA trial; Intuitive for robotic pancreatoduodenectomy training

Published
2024
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22. Minimally invasive robot-assisted and laparoscopic distal pancreatectomy in a pan-European registry a retrospective cohort study

Author

van Bodegraven, Eduard A, van Ramshorst, Tess M E, Bratlie, Svein O, Kokkola, Arto, Sparrelid, Ernesto, Björnsson, Bergthor, Kleive, Dyre, Burgdorf, Stefan K, Dokmak, Safi, Groot Koerkamp, Bas, Cabús, Santiago Sánchez, Molenaar, I Quintus, Boggi, Ugo, Busch, Olivier R, Petrič, Miha, Roeyen, Geert, Hackert, Thilo, Lips, Daan J, D'Hondt, Mathieu, Coolsen, Mariëlle M E, Ferrari, Giovanni, Tingstedt, Bobby, Serrablo, Alejandro, Gaujoux, Sebastien, Ramera, Marco, Khatkov, Igor, Ausania, Fabio, Souche, Regis, Festen, Sebastiaan, Berrevoet, Frederik, Keck, Tobias, Sutcliffe, Robert P, Pando, Elizabeth, de Wilde, Roeland F, Aussilhou, Beatrice, Krohn, Paul S, Edwin, Bjørn, Sandström, Per, Gilg, Stefan, Seppänen, Hanna, Vilhav, Caroline, Abu Hilal, Mohammad, Besselink, Marc G, van Bodegraven, Eduard A, van Ramshorst, Tess M E, Bratlie, Svein O, Kokkola, Arto, Sparrelid, Ernesto, Björnsson, Bergthor, Kleive, Dyre, Burgdorf, Stefan K, Dokmak, Safi, Groot Koerkamp, Bas, Cabús, Santiago Sánchez, Molenaar, I Quintus, Boggi, Ugo, Busch, Olivier R, Petrič, Miha, Roeyen, Geert, Hackert, Thilo, Lips, Daan J, D'Hondt, Mathieu, Coolsen, Mariëlle M E, Ferrari, Giovanni, Tingstedt, Bobby, Serrablo, Alejandro, Gaujoux, Sebastien, Ramera, Marco, Khatkov, Igor, Ausania, Fabio, Souche, Regis, Festen, Sebastiaan, Berrevoet, Frederik, Keck, Tobias, Sutcliffe, Robert P, Pando, Elizabeth, de Wilde, Roeland F, Aussilhou, Beatrice, Krohn, Paul S, Edwin, Bjørn, Sandström, Per, Gilg, Stefan, Seppänen, Hanna, Vilhav, Caroline, Abu Hilal, Mohammad, and Besselink, Marc G

Abstract

BACKGROUND: International guidelines recommend monitoring the use and outcome of minimally invasive pancreatic surgery (MIPS). However, data from prospective international audits on minimally invasive distal pancreatectomy (MIDP) are lacking. This study examined the use and outcome of robot-assisted (RDP) and laparoscopic (LDP) distal pancreatectomy in the E-MIPS registry. PATIENTS AND METHODS: Post-hoc analysis in a prospective audit on MIPS, including consecutive patients undergoing MIDP in 83 centers from 19 European countries (01-01-2019/31-12-2021). Primary outcomes included intraoperative events (grade 1: excessive blood loss, grade 2: conversion/change in operation, grade 3: intraoperative death), major morbidity, and in-hospital/30-day mortality. Multivariable logistic regression analyses identified high-risk groups for intraoperative events. RDP and LDP were compared in the total cohort and high-risk groups. RESULTS: Overall, 1672 patients undergoing MIDP were included; 606 (36.2%) RDP and 1066 (63.8%) LDP. The annual use of RDP increased from 30.5% to 42.6% ( P <0.001). RDP was associated with fewer grade 2 intraoperative events compared with LDP (9.6% vs. 16.8%, P <0.001), with longer operating time (238 vs. 201 min, P <0.001). No significant differences were observed between RDP and LDP regarding major morbidity (23.4% vs. 25.9%, P =0.264) and in-hospital/30-day mortality (0.3% vs. 0.8%, P =0.344). Three high-risk groups were identified; BMI greater than 25 kg/m 2 , previous abdominal surgery, and vascular involvement. In each group, RDP was associated with fewer conversions and longer operative times. CONCLUSION: This European registry-based study demonstrated favorable outcomes for MIDP, with mortality rates below 1%. LDP remains the predominant approach, whereas the use of RDP is increasing. RDP was associated with fewer conversions and longer operative time, including in high-risk subgroups. Future randomized trials should confirm these f

Published
2024

28. Postoperative Hyperamylasemia (POH) is an Early Predictor of Pancreatic Fistula Occurrence and Severity after Distal Pancreatectomy

Author

Perri, Giampaolo, primary, Romandini, Elisa, additional, Marchegiani, Giovanni, additional, Ghorbani, Poya, additional, Sahakyan, Musheg, additional, Holmberg, Marcus, additional, Cattelani, Alice, additional, Fretland, Åsmund, additional, Montorsi, Roberto, additional, Rodrigues, Isabella D, additional, Kleive, Dyre, additional, Bannone, Elisa, additional, Edwin, Bjørn, additional, Gilg, Stefan, additional, Labori, Knut, additional, Sparrelid, Ernesto, additional, and Salvia, Roberto, additional

Published
2024
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29. Minimally invasive robot-assisted and laparoscopic distal pancreatectomy in a pan-European registry a retrospective cohort study.

Author

van Bodegraven, Eduard A., van Ramshorst, Tess M. E., Bratlie, Svein O., Kokkola, Arto, Sparrelid, Ernesto, Björnsson, Bergthor, Kleive, Dyre, Burgdorf, Stefan K., Dokmak, Safi, Koerkamp, Bas Groot, Cabús, Santiago Sánchez, Molenaar, I. Quintus, Boggi, Ugo, Busch, Olivier R., Petrič, Miha, Roeyen, Geert, Hackert, Thilo, Lips, Daan J., D'Hondt, Mathieu, and Coolsen, Mariëlle M. E.

Abstract

Background: International guidelines recommend monitoring the use and outcome of minimally invasive pancreatic surgery (MIPS). However, data from prospective international audits on minimally invasive distal pancreatectomy (MIDP) are lacking. This study examined the use and outcome of robot-assisted (RDP) and laparoscopic (LDP) distal pancreatectomy in the E-MIPS registry. Patients and methods: Post-hoc analysis in a prospective audit on MIPS, including consecutive patients undergoing MIDP in 83 centers from 19 European countries (01-01-2019/31-12-2021). Primary outcomes included intraoperative events (grade 1: excessive blood loss, grade 2: conversion/change in operation, grade 3: intraoperative death), major morbidity, and in-hospital/30-day mortality. Multivariable logistic regression analyses identified high-risk groups for intraoperative events. RDP and LDP were compared in the total cohort and high-risk groups. Results: Overall, 1672 patients undergoing MIDP were included; 606 (36.2%) RDP and 1066 (63.8%) LDP. The annual use of RDP increased from 30.5% to 42.6% (P<0.001). RDP was associated with fewer grade 2 intraoperative events compared with LDP (9.6% vs. 16.8%, P< 0.001), with longer operating time (238 vs. 201 min, P<0.001). No significant differences were observed between RDP and LDP regarding major morbidity (23.4% vs. 25.9%, P =0.264) and in-hospital/30-day mortality (0.3% vs. 0.8%, P =0.344). Three high-risk groups were identified; BMI greater than 25 kg/m2, previous abdominal surgery, and vascular involvement. In each group, RDP was associated with fewer conversions and longer operative times. Conclusion: This European registry-based study demonstrated favorable outcomes for MIDP, with mortality rates below 1%. LDP remains the predominant approach, whereas the use of RDP is increasing. RDP was associated with fewer conversions and longer operative time, including in high-risk subgroups. Future randomized trials should confirm these findings and assess cost differences. [ABSTRACT FROM AUTHOR]

Published
2024
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31. The value of splenectomy during left-sided pancreatectomy for pancreatic ductal adenocarcinoma: predefined subanalysis in the DIPLOMA randomized trial.

Author

Bruna, Caro L, van Hilst, Jony, Esposito, Alessandro, Kleive, Dyre, Falconi, Massimo, Primrose, John N, Korrel, Maarten, Bianchi, Denise, Zerbi, Alessando, Kokkola, Arto, Butturini, Giovanni, Björnsson, Bergthor, Morone, Mario, Casadei, Riccardo, Marudanayagam, Ravi, Besselink, Marc G, Abu Hilal, Mohammad, de Pastena, Matteo, Salvia, Roberto, and Tholfsen, Tore

Subjects
SURGERY, MEDICAL sciences, MINIMALLY invasive procedures, PANCREATECTOMY, ACADEMIC medical centers, PANCREATIC surgery
Abstract

This research letter published in the British Journal of Surgery examines the role of splenectomy during left-sided pancreatectomy for pancreatic ductal adenocarcinoma (PDAC). The authors analyzed data from the DIPLOMA randomized trial, which included 185 patients with resectable left-sided PDAC. They found that splenic lymph node involvement was rare, particularly in patients with pancreatic body PDAC. The authors suggest that further studies are needed to determine the significance of splenectomy in left pancreatectomy for pancreatic cancer. The document also includes a table with data on various factors related to distal pancreatic cancer, which can be useful for researchers studying prognosis and treatment outcomes. [Extracted from the article]

Published
2024
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33. Resection rates and intention-to-treat outcomes in borderline and locally advanced pancreatic cancer: real-world data from a population-based, prospective cohort study (NORPACT-2)

Author

Farnes, Ingvild, primary, Kleive, Dyre, additional, Verbeke, Caroline S, additional, Aabakken, Lars, additional, Issa-Epe, Aart, additional, Småstuen, Milada Cvancarova, additional, Fosby, Bjarte V, additional, Dueland, Svein, additional, Line, Pål-Dag, additional, and Labori, Knut J, additional

Published
2023
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39. Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trial

Author

Korrel, Maarten, primary, Jones, Leia R., additional, van Hilst, Jony, additional, Balzano, Gianpaolo, additional, Björnsson, Bergthor, additional, Boggi, Ugo, additional, Bratlie, Svein Olav, additional, Busch, Olivier R., additional, Butturini, Giovanni, additional, Capretti, Giovanni, additional, Casadei, Riccardo, additional, Edwin, Bjørn, additional, Emmen, Anouk M.L.H., additional, Esposito, Alessandro, additional, Falconi, Massimo, additional, Groot Koerkamp, Bas, additional, Keck, Tobias, additional, de Kleine, Ruben H.J., additional, Kleive, Dyre B., additional, Kokkola, Arto, additional, Lips, Daan J., additional, Lof, Sanne, additional, Luyer, Misha D.P., additional, Manzoni, Alberto, additional, Marudanayagam, Ravi, additional, de Pastena, Matteo, additional, Pecorelli, Nicolò, additional, Primrose, John N., additional, Ricci, Claudio, additional, Salvia, Roberto, additional, Sandström, Per, additional, Vissers, Frederique L.I.M., additional, Wellner, Ulrich F., additional, Zerbi, Alessandro, additional, Dijkgraaf, Marcel G.W., additional, Besselink, Marc G., additional, Abu Hilal, Mohammad, additional, Alseidi, Adnan, additional, Aquilano, Constanza, additional, Arola, Johanna, additional, Bianchi, Denise, additional, Brown, Rachel, additional, Campani, Daniela, additional, ChinAleong, Joanne, additional, Cros, Jerome, additional, Dimitrova, Lyubomira, additional, Doglioni, Claudio, additional, Dokmak, Safi, additional, Dorer, Russell, additional, Doukas, Michael, additional, Fabre, Jean Michel, additional, Ferrari, Giovanni, additional, Grinevich, Viacheslay, additional, Gobbo, Stefano, additional, Hackert, Thilo, additional, van den Heuvel, Marius, additional, Huijsentruijt, Clement, additional, Iglesias, Mar, additional, Jansen, Casper, additional, Khatkov, Igor, additional, Kooby, David, additional, Lena, Marco, additional, Luchini, Claudio, additional, Menon, Krishna, additional, Michenet, Patrick, additional, Molenaar, Quintus, additional, Nedkova, Anna, additional, Pietrabissa, Andrea, additional, Raicu, Mihaela, additional, Rajak, Rushda, additional, Rankovic, Branislava, additional, Rendek, Aniko, additional, Riviere, Benjamin, additional, Cunha, Antonio Sa, additional, Marc, Olivier Saint, additional, Velazquez, Patricia Sanchez, additional, Santini, Donatella, additional, Scarpa, Aldo, additional, Sebagh, Mylene, additional, Sears, Donald, additional, Shah, Mihir, additional, Soonawalla, Zahir, additional, Spaggiari, Paola, additional, Tharun, Lars, additional, Tholfsen, Tore, additional, Tomazic, Ales, additional, Vanoli, Alessandro, additional, Verbeke, Caroline, additional, Verheij, Joanne, additional, Von Winterfeld, Moritz, additional, de Wilde, Roeland, additional, Yip, Vincent, additional, and Zen, Yoh, additional

Published
2023
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42. Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trial

Author

Korrel, Maarten, Jones, Leia R., van Hilst, Jony, Balzano, Gianpaolo, Björnsson, Bergthor, Boggi, Ugo, Bratlie, Svein Olav, Busch, Olivier R., Butturini, Giovanni, Capretti, Giovanni, Casadei, Riccardo, Edwin, Bjorn, Emmen, Anouk M. L. H., Esposito, Alessandro, Falconi, Massimo, Koerkamp, Bas Groot, Keck, Tobias, de Kleine, Ruben H. J., Kleive, Dyre B., Kokkola, Arto, Lips, Daan J., Lof, Sanne, Luyer, Misha D. P., Manzoni, Alberto, Marudanayagam, Ravi, de Pastena, Matteo, Pecorelli, Nicolo, Primrose, John N., Ricci, Claudio, Salvia, Roberto, Sandström, Per, Vissers, Frederique L. I. M., Wellner, Ulrich F., Zerbi, Alessandro, Dijkgraaf, Marcel G. W., Besselink, Marc G., Abu Hilal, Mohammad, Korrel, Maarten, Jones, Leia R., van Hilst, Jony, Balzano, Gianpaolo, Björnsson, Bergthor, Boggi, Ugo, Bratlie, Svein Olav, Busch, Olivier R., Butturini, Giovanni, Capretti, Giovanni, Casadei, Riccardo, Edwin, Bjorn, Emmen, Anouk M. L. H., Esposito, Alessandro, Falconi, Massimo, Koerkamp, Bas Groot, Keck, Tobias, de Kleine, Ruben H. J., Kleive, Dyre B., Kokkola, Arto, Lips, Daan J., Lof, Sanne, Luyer, Misha D. P., Manzoni, Alberto, Marudanayagam, Ravi, de Pastena, Matteo, Pecorelli, Nicolo, Primrose, John N., Ricci, Claudio, Salvia, Roberto, Sandström, Per, Vissers, Frederique L. I. M., Wellner, Ulrich F., Zerbi, Alessandro, Dijkgraaf, Marcel G. W., Besselink, Marc G., and Abu Hilal, Mohammad

Abstract

Background The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use of minimally invasive distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking. Methods In this international randomised non-inferiority trial, we recruited adults with resectable pancreatic cancer from 35 centres in 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) or open distal pancreatectomy (ODP). Both patients and pathologists were blinded to the assigned approach. Primary endpoint was radical resection (R0, & GE;1 mm free margin) in patients who had ultimately undergone resection. Analyses for the primary endpoint were by modified intention-to-treat, excluding patients with missing data on primary endpoint. The pre-defined non-inferiority margin of -7% was compared with the lower limit of the two-sided 90% confidence interval (CI) of absolute difference in the primary endpoint. This trial is registered with the ISRCTN registry (ISRCTN44897265). Findings Between May 8, 2018 and May 7, 2021, 258 patients were randomly assigned to MIDP (131 patients) or ODP (127 patients). Modified intention-to-treat analysis included 114 patients in the MIDP group and 110 patients in the ODP group. An R0 resection occurred in 83 (73%) patients in the MIDP group and in 76 (69%) patients in the ODP group (difference 3.7%, 90% CI -6.2 to 13.6%; pnon-inferiority = 0.039). Median lymph node yield was comparable (22.0 [16.0-30.0] vs 23.0 [14.0-32.0] nodes, p = 0.86), as was the rate of intraperitoneal recurrence (41% vs 38%, p = 0.45). Median follow-up was 23.5 (interquartile range 17.0-30.0) months. Other postoperative outcomes were comparable, including median time to functional recovery (5 [95% CI 4.5-5.5] vs 5 [95% CI 4.7-5.3] days; p = 0.22) and overall survival (HR 0.99, 95% CI 0.67-1.46, p = 0.94). Serious adverse events were reported i, Funding Agencies|Medtronic Covidien AG; Johnson amp; Johnson Medical Limited; Dutch Gastroenterology Society

Published
2023
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46. Benchmarking of minimally invasive distal pancreatectomy with splenectomy: European multicentre study

Author

Giani, Alessandro, van Ramshorst, Tess, Mazzola, Michele, Bassi, Claudio, Esposito, Alessandro, de Pastena, Matteo, Edwin, Bjørn, Sahakyan, Mushegh, Kleive, Dyre, Jah, Asif, van Laarhoven, Stijn, Boggi, Ugo, Kauffman, Emanuele Federico, Casadei, Riccardo, Ricci, Claudio, Dokmak, Safi, Ftériche, Fadhel Samir, White, Steven A., Kamarajah, Sivesh K., Butturini, Giovanni, Frigerio, Isabella, Zerbi, Alessandro, Capretti, Giovanni, Pando, Elizabeth, Sutcliffe, Robert P., Marudanayagam, Ravi, Fusai, Giuseppe Kito, Fabre, Jean Michel, Björnsson, Bergthor, Timmermann, Lea, Soonawalla, Zahir, Burdio, Fernando, Keck, Tobias, Hackert, Thilo, Groot Koerkamp, Bas, d'Hondt, Mathieu, Coratti, Andrea, Pessaux, Patrick, Pietrabissa, Andrea, Al-Sarireh, Bilal, Marino, Marco V., Molenaar, Quintus, Yip, Vincent, Besselink, Marc, Ferrari, Giovanni, Hilal, Mohammad Abu, Surgery, CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Male, minimally invasive distal pancreatectomy, pancreatectomy, pancreatic surgery, Pancreatic Neoplasms, Benchmarking, Pancreatectomy, Postoperative Complications, Treatment Outcome, minimally invasive distal pancreatectomy, Splenectomy, Humans, Laparoscopy, Surgery, pancreatic surgery, Retrospective Studies
Abstract

Background Benchmarking is the process to used assess the best achievable results and compare outcomes with that standard. This study aimed to assess best achievable outcomes in minimally invasive distal pancreatectomy with splenectomy (MIDPS). Methods This retrospective study included consecutive patients undergoing MIDPS for any indication, between 2003 and 2019, in 31 European centres. Benchmarks of the main clinical outcomes were calculated according to the Achievable Benchmark of Care (ABC™) method. After identifying independent risk factors for severe morbidity and conversion, risk-adjusted ABCs were calculated for each subgroup of patients at risk. Results A total of 1595 patients were included. The ABC was 2.5 per cent for conversion and 8.4 per cent for severe morbidity. ABC values were 160 min for duration of operation time, 8.3 per cent for POPF, 1.8 per cent for reoperation, and 0 per cent for mortality. Multivariable analysis showed that conversion was associated with male sex (OR 1.48), BMI exceeding 30 kg/m2 (OR 2.42), multivisceral resection (OR 3.04), and laparoscopy (OR 2.24). Increased risk of severe morbidity was associated with ASA fitness grade above II (OR 1.60), multivisceral resection (OR 1.88), and robotic approach (OR 1.87). Conclusion The benchmark values obtained using the ABC method represent optimal outcomes from best achievable care, including low complication rates and zero mortality. These benchmarks should be used to set standards to improve patient outcomes.

Published
2022

47. Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): Study protocol for a multicentre randomized placebo-controlled trial

Author

Yaqub, Sheraz, Bjørnbeth, Bjørn Atle, Angelsen, Jon-Helge, Fristrup, Claus W., Grønbech, Jon Erik, Hemmingsson, Oskar, Isaksson, Bengt, Juel, Ingebjørg Soterud, Larsen, Peter Nørgaard, Lindell, Gert, Mortensen, Frank V., Mortensen, Kim Erlend, Rizell, Magnus, Sandström, Per, Sandvik, Oddvar Mathias, Sparrelid, Ernesto, Taflin, Helena, Taskén, Kjetil, Brudvik, Kristoffer Watten, Fretland, Åsmund Avdem, Horn, Arild, Kleive, Dyre, Labori, Knut Jørgen, Lassen, Kristoffer, Røsok, Bård Ingvald, Søreide, Jon Arne, Tholfsen, Tore, Villanger, Olaug, and Waage, Anne

Subjects
medicine.medical_specialty, Medicine (General), Colorectal cancer, medicine.medical_treatment, Placebo-controlled study, Medicine (miscellaneous), Placebo, Metastasis, Study Protocol, Liver metastases, R5-920, Double-Blind Method, Quality of life, Acetylsalicylic acid, Aspirin, Secondary prevention, Internal medicine, medicine, Humans, Multicenter Studies as Topic, Pharmacology (medical), Randomized Controlled Trials as Topic, Cancer och onkologi, business.industry, Incidence (epidemiology), Liver Neoplasms, medicine.disease, Cancer and Oncology, Quality of Life, Neoplasm Recurrence, Local, Colorectal Neoplasms, business, Adjuvant, medicine.drug
Abstract

Background Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose aspirin (acetylsalicylic acid (ASA)) can improve disease-free survival in patients treated for colorectal cancer liver metastases (CRCLM). Up to 800 patients operated for CRCLM will be randomized to Arm#1 ASA 160 mg once daily or Arm#2 Placebo, for a period of 3 years or until disease recurrence. The patients will be recruited at all major hepatobiliary surgical units in Norway, Sweden and Denmark and have follow-up according to standard of care and the National Guidelines. Discussion The ASAC trial will be the first clinical interventional trial to assess the potential beneficial role of ASA in recurrence of CRCLM and survival. ASA is an inexpensive, well-tolerated and easily accessible drug that will be highly potential as adjuvant drug in secondary prevention of CRCLM if the study shows a beneficial effect. We will also determine the effect of ASA as adjuvant treatment on Health-Related Quality of Life and the cost-effectiveness. Trial registration ClinicalTrials.gov NCT03326791. Registered on 31 October 2017.

Published
2021
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