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2. Interferometry with Bose-Einstein Condensates in Microgravity

Author

Müntinga, H., Ahlers, H., Krutzik, M., Wenzlawski, A., Arnold, S., Becker, D., Bongs, K., Dittus, H., Duncker, H., Gaaloul, N., Gherasim, C., Giese, E., Grzeschik, C., Hänsch, T. W., Hellmig, O., Herr, W., Herrmann, S., Kajari, E., Kleinert, S., Lämmerzahl, C., Lewoczko-Adamczyk, W., Malcolm, J., Meyer, N., Nolte, R., Peters, A., Popp, M., Reichel, J., Roura, A., Rudolph, J., Schiemangk, M., Schneider, M., Seidel, S. T., Sengstock, K., Tamma, V., Valenzuela, T., Vogel, A., Walser, R., Wendrich, T., Windpassinger, P., Zeller, W., Zoest, T. van, Ertmer, W., Schleich, W. P., Rasel, E. M., Müntinga, H., Ahlers, H., Krutzik, M., Wenzlawski, A., Arnold, S., Becker, D., Bongs, K., Dittus, H., Duncker, H., Gaaloul, N., Gherasim, C., Giese, E., Grzeschik, C., Hänsch, T. W., Hellmig, O., Herr, W., Herrmann, S., Kajari, E., Kleinert, S., Lämmerzahl, C., Lewoczko-Adamczyk, W., Malcolm, J., Meyer, N., Nolte, R., Peters, A., Popp, M., Reichel, J., Roura, A., Rudolph, J., Schiemangk, M., Schneider, M., Seidel, S. T., Sengstock, K., Tamma, V., Valenzuela, T., Vogel, A., Walser, R., Wendrich, T., Windpassinger, P., Zeller, W., Zoest, T. van, Ertmer, W., Schleich, W. P., and Rasel, E. M.

Abstract

Atom interferometers covering macroscopic domains of space-time are a spectacular manifestation of the wave nature of matter. Because of their unique coherence properties, Bose-Einstein condensates are ideal sources for an atom interferometer in extended free fall. In this Letter we report on the realization of an asymmetric Mach-Zehnder interferometer operated with a Bose-Einstein condensate in microgravity. The resulting interference pattern is similar to the one in the far field of a double slit and shows a linear scaling with the time the wave packets expand. We employ delta-kick cooling in order to enhance the signal and extend our atom interferometer. Our experiments demonstrate the high potential of interferometers operated with quantum gases for probing the fundamental concepts of quantum mechanics and general relativity.

Published
2024

3. Interferometry with Bose-Einstein Condensates in Microgravity

Author

Müntinga, H., Ahlers, H., Krutzik, M., Wenzlawski, A., Arnold, S., Becker, D., Bongs, K., Dittus, H., Duncker, H., Gaaloul, N., Gherasim, C., Giese, E., Grzeschik, C., Hänsch, T. W., Hellmig, O., Herr, W., Herrmann, S., Kajari, E., Kleinert, S., Lämmerzahl, C., Lewoczko-Adamczyk, W., Malcolm, J., Meyer, N., Nolte, R., Peters, A., Popp, M., Reichel, J., Roura, A., Rudolph, J., Schiemangk, M., Schneider, M., Seidel, S. T., Sengstock, K., Tamma, V., Valenzuela, T., Vogel, A., Walser, R., Wendrich, T., Windpassinger, P., Zeller, W., van Zoest, T., Ertmer, W., Schleich, W. P., and Rasel, E. M.

Subjects
Physics - Atomic Physics, Condensed Matter - Quantum Gases, Quantum Physics
Abstract

Atom interferometers covering macroscopic domains of space-time are a spectacular manifestation of the wave nature of matter. Due to their unique coherence properties, Bose-Einstein condensates are ideal sources for an atom interferometer in extended free fall. In this paper we report on the realization of an asymmetric Mach-Zehnder interferometer operated with a Bose-Einstein condensate in microgravity. The resulting interference pattern is similar to the one in the far-field of a double-slit and shows a linear scaling with the time the wave packets expand. We employ delta-kick cooling in order to enhance the signal and extend our atom interferometer. Our experiments demonstrate the high potential of interferometers operated with quantum gases for probing the fundamental concepts of quantum mechanics and general relativity., Comment: 8 pages, 3 figures; 8 pages of supporting material

Published
2013
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4. POS0377 ACCURACY OF AN AI-BASED SYMPTOM CHECKER AND AN ONLINE SELF-REFERRAL TOOL IN RHEUMATOLOGY: RESULTS FROM A MULTICENTER RANDOMIZED CONTROLLED TRIAL

Author

Knitza, J., primary, Tascilar, K., additional, Fuchs, F., additional, Mohn, J., additional, Simon, D., additional, Kleyer, A., additional, Bergmann, C., additional, Labinsky, H., additional, Morf, H., additional, Araujo, E., additional, Bohr, D., additional, Muehlensiepen, F., additional, Englbrecht, M., additional, Vorbrüggen, W., additional, Von der Decken, C. B., additional, Kleinert, S., additional, Ramming, A., additional, Distler, J., additional, Bartz-Bazzanella, P., additional, Vuillerme, N., additional, Schett, G., additional, Welcker, M., additional, and Hueber, A., additional

Published
2023
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5. Röntgenologische versus non-röntgenologische axiale Spondyloarthritis - auch eine Real-World-Klassifikation?

Author

Kleinert, S, Kuhn, C, Vorbrüggen, W, Popp, F, Rapp, P, Bartz-Bazzanella, P, Schuch, F, Welcker, M, Karberg, K, Sternad, P, von der Decken, C, Wendler, J, Späthling-Mestekemper, S, Gauler, G, Wurth, P, Ronneberger, M, Kleinert, S, Kuhn, C, Vorbrüggen, W, Popp, F, Rapp, P, Bartz-Bazzanella, P, Schuch, F, Welcker, M, Karberg, K, Sternad, P, von der Decken, C, Wendler, J, Späthling-Mestekemper, S, Gauler, G, Wurth, P, and Ronneberger, M

Published
2023

9. Langfristige humorale Immunantwort auf die SARS-CoV-2-Impfung bei Patienten mit immunvermittelten entzündlichen Erkrankungen

Author

Tascilar, K, Simon, D, Kleyer, A, Fagni, F, Krönke, G, Meder, C, Dietrich, P, Orlemann, T, Kliem, T, Mößner, J, Liphardt, AM, Schönau, V, Bohr, D, Schuster, L, Hartmann, F, Taubmann, J, Minopoulou, I, Leppkes, M, Ramming, A, Pachowsky, M, Schuch, F, Ronneberger, M, Kleinert, S, Hueber, A, Manger, K, Manger, B, Atreya, R, Berking, C, Sticherling, M, Neurath, MF, Schett, G, Tascilar, K, Simon, D, Kleyer, A, Fagni, F, Krönke, G, Meder, C, Dietrich, P, Orlemann, T, Kliem, T, Mößner, J, Liphardt, AM, Schönau, V, Bohr, D, Schuster, L, Hartmann, F, Taubmann, J, Minopoulou, I, Leppkes, M, Ramming, A, Pachowsky, M, Schuch, F, Ronneberger, M, Kleinert, S, Hueber, A, Manger, K, Manger, B, Atreya, R, Berking, C, Sticherling, M, Neurath, MF, and Schett, G

Published
2022

12. Die 'ARIAA-Studie' - Abatacept verzögert den Übergang in eine RA bei at-risk-Patienten - klinische Ergebnisse zu Monat 18 der internationalen, randomisiert, placebo kontrollierten Studie

Author

Rech, J, Kleyer, A, Ostergaard, M, Feuchtenberger, M, Hagen, M, Valor Mendez, L, Koray, T, Kroenke, G, Schönau, V, Kleinert, S, Baraliakos, X, Braun, J, Fleck, M, Rubbert-Roth, A, Behrens, F, Zaenker, M, Kofler, DM, Simon, D, Glaser, C, Hueber, A, Voll, R, Feist, E, Burmester, GR, Karberg, K, Strunk, J, Cañete, JdD, Senolt, L, Naredo, E, Schett, G, Rech, J, Kleyer, A, Ostergaard, M, Feuchtenberger, M, Hagen, M, Valor Mendez, L, Koray, T, Kroenke, G, Schönau, V, Kleinert, S, Baraliakos, X, Braun, J, Fleck, M, Rubbert-Roth, A, Behrens, F, Zaenker, M, Kofler, DM, Simon, D, Glaser, C, Hueber, A, Voll, R, Feist, E, Burmester, GR, Karberg, K, Strunk, J, Cañete, JdD, Senolt, L, Naredo, E, and Schett, G

Published
2022

13. ABATACEPT DELAYS THE DEVELOPMENT OF RA-CLINICAL RESULTS AFTER 18 MONTHS FROM THE RANDOMIZED, PLACEBO-CONTROLLED ARIAA STUDY IN RA-AT RISK PATIENTS

Author

Rech, J., Kleyer, A., Ostergaard, M., Hagen, M., Valor, L., Tascilar, K., Kronke, G., Schonau, V., Kleinert, S., Baraliakos, X., Braun, J., Fleck, M., Rubbert-Roth, A., Behrens, F., Feuchtenberger, M., Zaenker, M., Kofler, D. M., Voll, R., Glaser, C., Hueber, A., Feist, E., Burmester, G. R., Karberg, K., Strunk, J., Canete, J. D. D., Senolt, L., Naredo, E., Schett, G., Rech, J., Kleyer, A., Ostergaard, M., Hagen, M., Valor, L., Tascilar, K., Kronke, G., Schonau, V., Kleinert, S., Baraliakos, X., Braun, J., Fleck, M., Rubbert-Roth, A., Behrens, F., Feuchtenberger, M., Zaenker, M., Kofler, D. M., Voll, R., Glaser, C., Hueber, A., Feist, E., Burmester, G. R., Karberg, K., Strunk, J., Canete, J. D. D., Senolt, L., Naredo, E., and Schett, G.

Published
2022

14. POS0531 ABATACEPT DELAYS THE DEVELOPMENT OF RA– CLINICAL RESULTS AFTER 18 MONTHS FROM THE RANDOMIZED, PLACEBO-CONTROLLED ARIAA STUDY IN RA-AT RISK PATIENTS

Author

Rech, J., primary, Kleyer, A., additional, Østergaard, M., additional, Hagen, M., additional, Valor, L., additional, Tascilar, K., additional, Krönke, G., additional, Schönau, V., additional, Kleinert, S., additional, Baraliakos, X., additional, Braun, J., additional, Fleck, M., additional, Rubbert-Roth, A., additional, Behrens, F., additional, Feuchtenberger, M., additional, Zaenker, M., additional, Kofler, D. M., additional, Voll, R., additional, Glaser, C., additional, Hueber, A., additional, Feist, E., additional, Burmester, G. R., additional, Karberg, K., additional, Strunk, J., additional, Cañete, J. D. D., additional, Šenolt, L., additional, Naredo, E., additional, and Schett, G., additional

Published
2022
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15. POS0260 LONG-TERM HUMORAL RESPONSE TO SARS-CoV-2 VACCINATION IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASE

Author

Tascilar, K., primary, Simon, D., additional, Kleyer, A., additional, Fagni, F., additional, Krönke, G., additional, Meder, C., additional, Dietrich, P., additional, Orlemann, T., additional, Kliem, T., additional, Mößner, J., additional, Liphardt, A. M., additional, Schönau, V., additional, Bohr, D., additional, Schuster, L., additional, Hartmann, F., additional, Taubmann, J., additional, Leppkes, M., additional, Ramming, A., additional, Pachowsky, M., additional, Schuch, F., additional, Ronneberger, M., additional, Kleinert, S., additional, Hueber, A., additional, Manger, K., additional, Manger, B., additional, Atreya, R., additional, Berking, C., additional, Sticherling, M., additional, Neurath, M. F., additional, and Schett, G., additional

Published
2022
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19. Tiltification — An Accessible App to Popularize Sonification

Author

Ziemer T, Kienzle M, Wang X, Bhowmik D, Jaman H, Jadid Nm, Sharma K, Awadin A, Schade Ees, Lee Yy, Weber C, Ahmadi F, Raval, Kleinert S, Asendorf M, Winkler H, Huynh K, Kruesilp J, Chen J, Luo W, and Ringe R

Subjects
Auditory feedback, Computer science, Sonification, Human–computer interaction, GeneralLiterature_MISCELLANEOUS, algebra_number_theory
Abstract

This paper presents Tiltification, a multi modal spirit level application for smartphones. The non-profit app was produced by students in the master project “Sonification Apps” in winter term 2020/21 at the University of Bremen. In the app, psychoacoustic sonification is used to give feedback on the device’s rotation angles in two plane dimensions, allowing users to level furniture or take perfectly horizontal photos. Tiltification supplements the market of spirit level apps with the unique feature of auditory information processing. This provides for additional benefit in comparison to a physical spirit level and for more accessibility for visu- ally and cognitively impaired people. We argue that the distribution of sonification apps through mainstream channels is a contribution to establish sonification in the market and make it better known to users outside the scientific domain. We hope that the auditory display community will support us by using and recommending the app and by providing valuable feedback on the app functionality and design, and on our communication, advertisement and distribution strategy.

Published
2021

21. Therapiewechsel bei der axialen Spondyloarthritis - Real-World-Daten aus dem Rhadar-Netzwerk

Author

Kleinert, S, Bartz-Bazzanella, P, Von der Decken, CB, Karberg, K, Schuch, F, Gauler, G, Wurth, P, Späthling-Mestekemper, S, Kuhn, C, Proft, F, Poddubnyy, D, Englbrecht, M, Vorbrüggen, W, Welcker, M, Kleinert, S, Bartz-Bazzanella, P, Von der Decken, CB, Karberg, K, Schuch, F, Gauler, G, Wurth, P, Späthling-Mestekemper, S, Kuhn, C, Proft, F, Poddubnyy, D, Englbrecht, M, Vorbrüggen, W, and Welcker, M

Published
2021

25. OP0318 TREATMENT TAPERING AND WITHDRAWAL IN RHEUMATOID ARTHRITIS WITH STABLE REMISSION - FINAL ANALYSIS OF THE RETRO STUDY

Author

Hagen, M., primary, Tascilar, K., additional, Reiser, M., additional, Valor, L., additional, Haschka, J., additional, Kleyer, A., additional, Hueber, A., additional, Manger, B., additional, Cobra, J., additional, Figuereido, C., additional, Finzel, S., additional, Tony, H. P., additional, Wendler, J., additional, Kleinert, S., additional, Schuch, F., additional, Ronneberger, M., additional, Feuchtenberger, M., additional, Fleck, M., additional, Manger, K., additional, Ochs, W., additional, Schmitt-Haendle, M., additional, Lorenz, H. M., additional, Alten, R., additional, Henes, J., additional, Krueger, K., additional, Rech, J., additional, and Schett, G., additional

Published
2021
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26. AB0494 COGNITIVE IMPAIRMENT IN AXIAL SPONDYLOARTHRITIS?

Author

Kleinert, S., primary, Rapp, P., additional, Schuch, F., additional, Ronneberger, M., additional, Wendler, J., additional, Sternad, P., additional, Popp, F., additional, Bartz-Bazzanella, P., additional, Von der Decken, C. B., additional, Karberg, K., additional, Gauler, G., additional, Wurth, P., additional, Spaethling-Mestekemper, S., additional, Kuhn, C., additional, Englbrecht, M., additional, Vorbrüggen, W., additional, Adler, G., additional, and Welcker, M., additional

Published
2021
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28. Symptomchecker in der Rheumatologie:Zwischenbericht der prospektiven bETTeR-Studie

Author

Knitza, J, Mohn, J, Bergmann, C, Kampylafka, E, Hagen, M, Bohr, D, Morf, H, Araujo, E, Englbrecht, M, Simon, D, Kleyer, A, Meinderink, T, Vorbrüggen, W, Von der Decken, CB, Kleinert, S, Ramming, A, Distler, J, Fricker, A, Bartz-Bazzanella, P, Schett, G, Hueber, A, Welcker, M, Knitza, J, Mohn, J, Bergmann, C, Kampylafka, E, Hagen, M, Bohr, D, Morf, H, Araujo, E, Englbrecht, M, Simon, D, Kleyer, A, Meinderink, T, Vorbrüggen, W, Von der Decken, CB, Kleinert, S, Ramming, A, Distler, J, Fricker, A, Bartz-Bazzanella, P, Schett, G, Hueber, A, and Welcker, M

Published
2020

31. AB1346-HPR REAL-WORLD EFFECTIVENESS AND PERCEIVED USEFULNESS OF SYMPTOM CHECKERS IN RHEUMATOLOGY: INTERIM REPORT FROM THE PROSPECTIVE MULTICENTER BETTER STUDY

Author

Knitza, J., primary, Mohn, J., additional, Bergmann, C., additional, Kampylafka, E., additional, Hagen, M., additional, Bohr, D., additional, Araujo, E., additional, Englbrecht, M., additional, Simon, D., additional, Kleyer, A., additional, Meinderink, T., additional, Vorbrüggen, W., additional, Von der Decken, C. B., additional, Kleinert, S., additional, Ramming, A., additional, Distler, J., additional, Bartz-Bazzanella, P., additional, Schett, G., additional, Hueber, A., additional, and Welcker, M., additional

Published
2020
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34. Towards eradication of chronic obstructive pulmonary disease: a Lancet Commission

Author

Dransfield, M, Stolz, D, Kleinert, S, Bafadhel, M, and Commissioners, Lancet Copd

Subjects
medicine.medical_specialty, business.industry, Vaping, Smoking, MEDLINE, Pulmonary disease, Environmental Exposure, General Medicine, Commission, Pulmonary Disease, Chronic Obstructive, Early Diagnosis, Cost of Illness, Risk Factors, Air Pollution, Prevalence, Cost of illness, Humans, Medicine, Disease Eradication, Mortality, business, Intensive care medicine
Published
2019

35. New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis

Author

Englbrecht, M., Alten, R., Aringer, M., Baerwald, C.G., Burkhardt, H., Eby, N., Flacke, J.-P., Fliedner, G., Henkemeier, U., Hofmann, M.W., Kleinert, S., Kneitz, C., Krüger, K., Pohl, C., Schett, G., Schmalzing, M., Tausche, A.-K., Tony, H.-P., Wendler, J., and Publica

Abstract

Objectives: To investigate the prevalence of depressive symptoms in rheumatoid arthritis (RA) patients using two previously validated questionnaires in a large patient sample, and to evaluate depressive symptoms in the context of clinical characteristics (e.g. remission of disease) and patient-reported impact of disease. Methods: In this cross-sectional study, the previously validated Patient Health Questionnaire (PHQ-9) and Beck-Depression Inventory II (BDI-II) were used to assess the extent of depressive symptoms in RA patients. Demographic background, RA disease activity score (DAS28), RA impact of disease (RAID) score, comorbidities, anti-rheumatic therapy and antidepressive treatment, were recorded. Cut-off values for depressive symptomatology were PHQ-9 >5 or BDI-II >14 for mild depressive symptoms or worse and PHQ-9 > 10 or BDI-II > 20 for moderate depressive symptoms or worse. Prevalence of depressive symptomatology was derived by frequency analysis while factors independently associated with depressive symptomatology were investigated by using multiple logistic regression analyses. Ethics committee approval was obtained, and all patients provided written informed consent before participation. Results: In 1004 RA-patients (75.1% female, mean±SD age: 61.0±12.9 years, mean disease duration: 12.2±9.9 years, DAS28 (ESR): 2.5±1.2), the prevalence of depressive symptoms was 55.4% (mild or worse) and 22.8% (moderate or worse). Characteristics independently associated with depressive symptomatology were: age 2 (OR = 10.54) and presence of chronic pain (OR = 3.25). Of patients classified as having depressive symptoms, only 11.7% were receiving anti-depressive therapy. Conclusions: Mild and moderate depressive symptoms were common in RA patients according to validated tools. In routine clinical practice, screening for depression with corresponding follow-up procedures is as relevant as incorporating these results with patient-reported outcomes (e.g. symptom state), because the mere assessment of clinical disease activity does not sufficiently reflect the prevalence of depressive symptoms.

Published
2019

36. Funktionalität (HAQ) bei RA Patienten mit Dosisreduktion bzw. Dosisreduktion/Stop der DMARD Therapie

Author

Stephan, M, Hagen, M, Englbrecht, M, Haschka, J, Reiser, M, Kleyer, A, Hueber, A, Hartmann, F, Manger, B, Figuereido, C, Cobra, JF, Tony, HP, Finzel, S, Kleinert, S, Wendler, J, Schuch, F, Ronneberger, M, Feuchtenberger, M, Fleck, M, Manger, K, Ochs, W, Schmitt-Haendle, M, Lorenz, HM, Nüsslein, H, Alten, RHE, Henes, J, Krüger, K, Tascilar, K, Schett, G, Rech, J, Stephan, M, Hagen, M, Englbrecht, M, Haschka, J, Reiser, M, Kleyer, A, Hueber, A, Hartmann, F, Manger, B, Figuereido, C, Cobra, JF, Tony, HP, Finzel, S, Kleinert, S, Wendler, J, Schuch, F, Ronneberger, M, Feuchtenberger, M, Fleck, M, Manger, K, Ochs, W, Schmitt-Haendle, M, Lorenz, HM, Nüsslein, H, Alten, RHE, Henes, J, Krüger, K, Tascilar, K, Schett, G, and Rech, J

Published
2019

37. Boolean Remission ohne DAS28 Remission? - Daten aus der RETRO Studie

Author

Erhard, J, Hagen, M, Englbrecht, M, Haschka, J, Reiser, M, Kleyer, A, Hueber, A, Manger, B, Figueiredo, C, Cobra, JF, Tony, HP, Finzel, S, Kleinert, S, Wendler, J, Schuch, F, Ronneberger, M, Feuchtenberger, M, Fleck, M, Manger, K, Ochs, W, Schmitt-Haendle, M, Lorenz, HM, Nüsslein, H, Alten, RHE, Henes, J, Krüger, K, Schett, G, Rech, J, Erhard, J, Hagen, M, Englbrecht, M, Haschka, J, Reiser, M, Kleyer, A, Hueber, A, Manger, B, Figueiredo, C, Cobra, JF, Tony, HP, Finzel, S, Kleinert, S, Wendler, J, Schuch, F, Ronneberger, M, Feuchtenberger, M, Fleck, M, Manger, K, Ochs, W, Schmitt-Haendle, M, Lorenz, HM, Nüsslein, H, Alten, RHE, Henes, J, Krüger, K, Schett, G, and Rech, J

Published
2019

41. Einfluss von Adipositas und Diabetes auf Krankheitsaktivität und Krankheitslast bei Patienten mit rheumatoider Arthritis

Author

Huscher, D, Albrecht, K, Eidner, T, Karberg, K, Kleinert, S, Förster, G, and Zink, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Patienten mit rheumatoider Arthritis (RA) haben ein erhöhtes Risiko, an Diabetes mellitus (DM) zu erkranken. Wenig bekannt ist, welche Zusammenhänge es gibt zwischen DM als Komorbidität, Übergewicht und Krankheitsaktivität. Methoden: Vier Gruppen von Patienten[zum vollständigen Text gelangen Sie über die oben angegebene URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2017
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43. T cells, natural killer cells, and γδT cells in a large patient cohort with rheumatoid arthritis: influence of age and anti-rheumatic therapy.

Author

Schwaneck, EC, Renner, R, Junker, L, Tony, H-P, Kleinert, S, Gernert, M, Schmalzing, M, Gadeholt, O, and Schwaneck, E C

Subjects
KILLER cells, T cells, RHEUMATOID arthritis, RITUXIMAB, AGE groups, CELLS, T cell receptors
Abstract

Objective: The aim of this cohort study was to evaluate the distribution of natural killer (NK) cells and T-cell subsets, including γδT cells, in the peripheral blood of patients with rheumatoid arthritis (RA) in a large real-life patient cohort, taking into account the patients' demographics, disease characteristics, and anti-rheumatic therapy.Method: The study recruited 508 RA patients between November 2013 and August 2015. Lymphocyte differentiation using eight-colour flow cytometry (fluorescence-activated cell sorting) of the peripheral blood was performed for all patients. Clinical data, including age, gender, disease duration, serostatus, disease activity, antibody status, immunosuppressive therapy including use of different biological disease-modifying anti-rheumatic drugs (bDMARDs) and conventional synthetic DMARDs, were retrospectively assessed using electronic patient files. Multivariate regression analysis was performed to assess the effect of these variables on T-cell, NK-cell, and γδT-cell counts.Results: The median patient age was 61.0 years and 74.1% were female. The median disease duration of RA was 12.0 years. Median Disease Activity Score based on 28-joint count was 2.8 and 56.3% were treated with bDMARDs. There were no differences in immunosuppressive therapy between different age groups. While rituximab, abatacept, and tocilizumab had no influence on lymphocyte subdifferentiation, tumour necrosis factor (TNF) inhibitors and age significantly influenced the numbers of T cells, T-helper cells, T-NK cells, NK cells, and γδT cells.Conclusion: Age and TNF-inhibition therapy influence lymphocyte subdifferentiation in patients with RA. It may be prudent to use age- and therapy-adjusted standard values for lymphocyte subsets during clinical trials and treatment of RA. [ABSTRACT FROM AUTHOR]

Published
2020
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45. AB0252 Loosing das28-esr, but staying in boolean remission- is it possible? data from the prospective, randomised retro trial on rheumatoid arthritis patients in stable remission

Author

Erhard, J., primary, Hagen, M., additional, Englbrecht, M., additional, Haschka, J., additional, Reiser, M., additional, Kleyer, A., additional, Hueber, A.J., additional, Manger, B., additional, Figueiredo, C., additional, Cobra, J.F., additional, Tony, H.-P., additional, Finzel, S., additional, Kleinert, S., additional, Wendler, J., additional, Schuch, F., additional, Ronneberger, M., additional, Feuchtenberger, M., additional, Fleck, M., additional, Manger, K., additional, Ochs, W., additional, Schmitt-Haendle, M., additional, Lorenz, H., additional, Nuesslein, H., additional, Alten, R., additional, Henes, J., additional, Krueger, K., additional, Schett, G., additional, and Rech, J., additional

Published
2018
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47. Multi-Biomarker Disease Activity- und Autoantikörperstatus führen zu einem Kosteneffizienten Dosisreduktions-Algorithmus bei RA-Patienten in Remission

Author

Hagen, M, Englbrecht, M, Haschka, J, Reiser, M, Kleyer, A, Hueber, A, Manger, B, Figuereido, C, Cobra, J, Tony, HP, Finzel, S, Kleinert, S, Wendler, J, Schuch, F, Ronneberger, M, Feuchtenberger, M, Fleck, M, Manger, K, Ochs, W, Schmitt-Haendle, M, Lorenz, HM, Nüßlein, HG, Alten, RHE, Henes, J, Krüger, K, Schett, G, Rech, J, Hagen, M, Englbrecht, M, Haschka, J, Reiser, M, Kleyer, A, Hueber, A, Manger, B, Figuereido, C, Cobra, J, Tony, HP, Finzel, S, Kleinert, S, Wendler, J, Schuch, F, Ronneberger, M, Feuchtenberger, M, Fleck, M, Manger, K, Ochs, W, Schmitt-Haendle, M, Lorenz, HM, Nüßlein, HG, Alten, RHE, Henes, J, Krüger, K, Schett, G, and Rech, J

Published
2017

48. Datennetzwerk Rheuma 4.0 – Real World Data aus dem Praxisalltag

Author

Kleinert, S, Schuch, F, Späthling-Mestekemper, S, Feuchtenberger, M, Kuhn, C, and Welcker, M

Subjects
Versorgungsforschung, ddc: 610, Applikation, Real Life Data, 610 Medical sciences, Medicine, Datennetzwerk
Abstract

Einleitung: Die zunehmende EDV unterstütze rheumatologische Dokumentation sowie die Dokumentation von Patient Reported Outcomes mittels Smartphones ermöglichen eine neue Qualität der Datenerfassung in der rheumatologischen Versorgung. Methoden: Das Datennetzwerk Rheuma 4.0 (DNR_4.0)[zum vollständigen Text gelangen Sie über die oben angegebene URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2016
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49. Anwendungssoftware für PC und Mobilgeräte zum Patienten-Selbst-Management als Teil eines integrierten Tight-Control-Konzepts am Beispiel der digitalen Applikationen RheumaLive und AxSpALive

Author

Feuchtenberger, M, Kleinert, S, Schuch, F, Späthling-Mestekemper, S, Kuhn, C, and Welcker, M

Subjects
Versorgungsforschung, Patienten-Selbst-Management, ddc: 610, Applikation, 610 Medical sciences, Medicine, Tight-Control-Konzept
Abstract

Einleitung: Medizinische Applikationen können Arzt und Patient unterstützen, Krankheitsverläufe zu dokumentieren und Therapien zu optimieren. Wir schildern die An- und Einbindung patientenbezogener Alltagsdaten mittels digitaler Applikationen RheumaLive und AxSpALive an bestehende Praxissoftwareprogramme[zum vollständigen Text gelangen Sie über die oben angegebene URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2016
Full Text
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50. Validation of Standardized Questionnaires Evaluating Symptoms of Depression in Rheumatoid Arthritis Patients

Author

Englbrecht, M., Alten, R., Aringer, M., Baerwald, C.G., Burkhardt, H., Eby, N., Fliedner, G., Gauger, B., Henkemeier, U., Hofmann, M.W., Kleinert, S., Kneitz, C., Krueger, K., Pohl, C., Roske, A.-E., Schett, G., Schmalzing, M., Tausche, A.-K., Tony, H.P., Wendler, J., and Publica

Abstract

Objective: To validate standard self‐report questionnaires for depression screening in patients with rheumatoid arthritis (RA) and compare these measures to one another and to the Montgomery‐Åsberg Depression Rating Scale (MADRS), a standardized structured interview. Methods: In 9 clinical centers across Germany, depressive symptomatology was assessed in 262 adult RA patients at baseline (T0) and at 12 ± 2 weeks followup (T1) using the World Health Organization 5‐Item Well‐Being Index (WHO‐5), the Patient Health Questionnaire (PHQ‐9), and the Beck Depression Inventory II (BDI‐II). The construct validity of these depression questionnaires (using convergent and discriminant validity) was evaluated using Spearman's correlations at both time points. The test-retest reliability of the questionnaires was evaluated in RA patients who had not undergone a psychotherapeutic intervention or received antidepressants between T0 and T1. The sensitivity and the specificity of the questionnaires were calculated using the results of the MADRS, a structured interview, as the gold standard. Results: According to Spearman's correlation coefficients, all questionnaires met convergent validity criteria (r > |0.50|), with the BDI‐II performing best, while correlations with age and disease activity for all questionnaires met the criteria for discriminant validity (r < |0.50|). The only questionnaire to meet the predefined retest reliability criterion (r > 0.70) was the BDI‐II (rs = 0.77), which also achieved the best results for both sensitivity and specificity (>80%) when using the MADRS as the gold standard. Conclusion: The BDI‐II best met the predefined criteria, and the PHQ‐9 met most of the validity criteria, with lower sensitivity and specificity.

Published
2016

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