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1. UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

Author

Dumont-Lagacé, Maude, Li, Qi, Tanguay, Mégane, Chagraoui, Jalila, Kientega, Tibila, Cardin, Guillaume B., Brasey, Ann, Trofimov, Assya, Carli, Cédric, Ahmad, Imran, Bambace, Nadia M., Bernard, Léa, Kiss, Thomas L., Roy, Jean, Roy, Denis-Claude, Lemieux, Sébastien, Perreault, Claude, Rodier, Francis, Dufresne, Simon Frédéric, Busque, Lambert, Lachance, Silvy, Sauvageau, Guy, Cohen, Sandra, and Delisle, Jean-Sébastien

Published
2020
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2. Ex Vivo Generation and Infusion of Anti-Minor Histocompatibility Antigen Expanded T Cells for Patients Who Relapse after Allogeneic HLA-Matched Stem Cell Transplantation

Author

Roy, Denis-Claude, primary, Delisle, Jean-Sébastien, additional, Ahmad, Imran, additional, Leber, Brian, additional, Couture, Félix, additional, Thiant, Stephanie, additional, Kekre, Natasha, additional, Sidi Boumedine, Radia, additional, Carli, Cédric, additional, Brasey, Ann, additional, Bambace, Nadia M., additional, Bernard, Léa, additional, Cohen, Sandra, additional, Kiss, Thomas L., additional, Roy, Jean, additional, Sauvageau, Guy, additional, Veilleux, Olivier, additional, Perreault, Claude, additional, Busque, Lambert, additional, and Lachance, Silvy, additional

Published
2022
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3. Improved Outcomes of UM171-Expanded Cord Blood Transplantation Compared with Other Graft Sources: Real World Evidence

Author

Cohen, Sandra, primary, Bambace, Nadia M., additional, Ahmad, Imran, additional, Burns, Linda J., additional, Roy, Jean, additional, Lachance, Silvy, additional, Bernard, Léa, additional, Delisle, Jean-Sébastien, additional, Roy, Denis-Claude, additional, Kiss, Thomas L., additional, Veilleux, Olivier, additional, Zhang, Mei-Jie, additional, Tang, Xiao-Ying, additional, and Sauvageau, Guy, additional

Published
2022
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4. The EBMT Disease Risk Stratification System (DRSS) Allows Prediction of Relapse after Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome

Author

Kadri, Yasmine, primary, Phan, Michelle, additional, Bambace, Nadia, additional, Bernard, Léa, additional, Cohen, Sandra, additional, Delisle, Jean-Sébastien, additional, Kiss, Thomas L., additional, Lachance, Sylvia, additional, Roy, Denis-Claude, additional, Roy, Jean, additional, Sauvageau, Guy, additional, Veilleux, Olivier, additional, and Ahmad, Imran, additional

Published
2022
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7. UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

Author

Dumont-Lagacé, Maude, primary, Li, Qi, additional, Tanguay, Mégane, additional, Chagraoui, Jalila, additional, Kientega, Tibila, additional, Cardin, Guillaume B., additional, Brasey, Ann, additional, Trofimov, Assya, additional, Carli, Cédric, additional, Ahmad, Imran, additional, Bambace, Nadia M., additional, Bernard, Léa, additional, Kiss, Thomas L., additional, Roy, Jean, additional, Roy, Denis-Claude, additional, Lemieux, Sébastien, additional, Perreault, Claude, additional, Rodier, Francis, additional, Dufresne, Simon Frédéric, additional, Busque, Lambert, additional, Lachance, Silvy, additional, Sauvageau, Guy, additional, Cohen, Sandra, additional, and Delisle, Jean-Sébastien, additional

Published
2021
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8. Single UM171‐Expanded Cord Blood Transplants Support Robust T‐Cell Reconstitution with Low Rates of Severe Infections

Author

Dumont‐Lagacé, Maude, primary, Li, Qi, additional, Tanguay, Mégane, additional, Chagraoui, Jalila, additional, Kientega, Tibila, additional, Cardin, Guillaume B., additional, Brasey, Ann, additional, Trofimov, Assya, additional, Carli, Cédric, additional, Ahmad, Imran, additional, Bambace, Nadia, additional, Bernard, Léa, additional, Kiss, Thomas L., additional, Roy, Jean, additional, Roy, Denis‐Claude, additional, Lemieux, Sébastien, additional, Perreault, Claude, additional, Rodier, Francis, additional, Dufresne, Simon Frédéric, additional, Busque, Lambert, additional, Lachance, Silvy, additional, Sauvageau, Guy, additional, Cohen, Sandra, additional, and Delisle, Jean‐Sébastien, additional

Published
2020
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13. UM171 Modified Cord Blood Achieves Excellent Survival and Disease Control after 2 Years of Follow-up in High and Very High Risk Malignancies

Author

Cohen, Sandra, primary, Roy, Jean, additional, Delisle, Jean-Sébastien, additional, Bambace, Nadia M., additional, Ahmad, Imran, additional, Lachance, Silvy, additional, Bernard, Léa, additional, Barabe, Frederic, additional, Kiss, Thomas L., additional, Busque, Lambert, additional, Roy, Denis-Claude, additional, Milano, Filippo, additional, and Sauvageau, Guy, additional

Published
2019
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15. Minimal Residual Disease Evaluation Using 8-Color Flow Cytometry Predicts Risk of Relapse in High-Risk and/or Young Myeloma Patients Who Receive Bortezomib Consolidation after Frontline Tandem Transplantation

Author

Leblanc, Richard, primary, Ahmad, Imran, additional, Terra, Rafik, additional, Landais, Séverine, additional, Nkoue, Céline, additional, Sebag, Michael, additional, Lemieux Blanchard, Émilie, additional, Bambace, Nadia M., additional, Bernard, Léa, additional, Cohen, Sandra, additional, Delisle, Jean-Sébastien, additional, Kiss, Thomas L., additional, Lachance, Silvy, additional, Roy, Denis-Claude, additional, Sauvageau, Guy, additional, and Roy, Jean, additional

Published
2018
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16. Single UM171 Expanded Cord Blood Permits Transplantation of Better HLA Matched Cords with Excellent Gvhd Relapse Free Survival

Author

Cohen, Sandra, primary, Roy, Jean, additional, Lachance, Silvy, additional, Marinier, Anne, additional, Delisle, Jean-Sébastien, additional, Roy, Denis-Claude, additional, Busque, Lambert, additional, Ahmad, Imran, additional, Bambace, Nadia M., additional, Barabe, Frederic, additional, Bernard, Léa, additional, Kiss, Thomas L., additional, Bouchard, Philippe, additional, Caudrelier, Pierre, additional, Larochelle, Fannie, additional, Lemieux, Sébastien, additional, Tanguay, Mégane, additional, Chagraoui, Jalila, additional, Zandstra, Peter W., additional, and Sauvageau, Guy, additional

Published
2018
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17. Reduced Intensity Conditioned Sibling Transplantation Versus No Transplant in Intermediate or High Risk Acute Myeloid Leukemia: A Prospective Multi-Center Study in Patients 50-70 Years in First Complete Remission and with at Least One Potential Sibling Donor (ClinTrialGov 00342316)

Author

Brune, Mats, primary, Kiss, Thomas L., additional, Wallhult, Elisabeth, additional, Anderson, Harald, additional, Delage, Robert, additional, Finke, Jürgen, additional, Hebert, Josee, additional, Höglund, Martin, additional, Kaare, Ain, additional, Lazarevic, Vladimir, additional, Nicklasson, Malin, additional, Remes, Kari, additional, Ritchie, David, additional, Sabloff, Mitchell, additional, Spearing, Ruth, additional, Spyridonidis, Alexandros, additional, Szer, Jeffrey, additional, and Ljungman, Per, additional

Published
2018
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18. Bortezomib Consolidation after Frontline Auto-Allogeneic Transplant: Low Toxicity and Frequent Immunophenotypic Complete Responses in High-Risk or Young Myeloma Patients

Author

Roy, Jean, primary, Ahmad, Imran, additional, Terra, Rafik, additional, Landais, Séverine, additional, Sebag, Michael, additional, Lemieux-Blanchard, Émilie, additional, Bambace, Nadia M., additional, Bernard, Léa, additional, Cohen, Sandra, additional, Delisle, Jean-Sébastien, additional, Kiss, Thomas L., additional, Lachance, Silvy, additional, Roy, Denis-Claude, additional, Sauvageau, Guy, additional, and LeBlanc, Richard, additional

Published
2018
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19. Effectiveness of Continuous Infusion of Methylprednisolone for Prevention of Antithymocyte Globulin Infusion-Related Reactions in Preparative Regimens for Allogeneic Hematopoietic Cell Transplantation

Author

Bouchard, Philippe, primary, Brisebois-Boyer, Annie, additional, Charbonneau-Seguin, Noemie, additional, Bonhomme, Valerie, additional, Ahmad, Imran, additional, Bernard, Léa, additional, Bambace, Nadia M., additional, Cohen, Sandra, additional, Delisle, Jean-Sébastien, additional, Kiss, Thomas L., additional, Sauvageau, Guy, additional, Roy, Denis-Claude, additional, Roy, Jean, additional, and Lachance, Silvy, additional

Published
2018
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20. Pharmacoeconomic Impact and Transplant Outcome Associated to Carmustine (BCNU) Substitution with Bendamustine (Be) in the Conditioning Regimen Prior to Autologous Stem Cell Transplantation for Lymphoma Treatment

Author

Boisjoly, Josie-Anne, primary, Bouchard, Philippe, additional, Ahmad, Imran, additional, Bambace, Nadia M., additional, Bernard, Léa, additional, Cohen, Sandra, additional, Delisle, Jean-Sébastien, additional, Kiss, Thomas L., additional, Roy, Denis-Claude, additional, Sauvageau, Guy, additional, Roy, Jean, additional, and Lachance, Silvy, additional

Published
2018
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21. Single UM171 Expanded Cord Blood Transplant Is Feasible, Safe, and Permits Transplantation of Better HLA Matched Cords with Very Low Transplant Related Mortality

Author

Cohen, Sandra, primary, Roy, Jean, additional, Lachance, Silvy, additional, Marinier, Anne, additional, Roy, Denis-Claude, additional, Delisle, Jean-Sébastien, additional, Busque, Lambert, additional, Caudrelier, Pierre, additional, Larochelle, Fannie, additional, Bouchard, Philippe, additional, Bambace, Nadia M., additional, Bernard, Léa, additional, Kiss, Thomas L, additional, Lemieux, Sébastien, additional, Zandstra, Peter W., additional, and Sauvageau, Guy, additional

Published
2017
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23. UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

Author

Dumont-Lagacé, Maude, Li, Qi, Tanguay, Mégane, Chagraoui, Jalila, Kientega, Tibila, Cardin, Guillaume B., Brasey, Ann, Trofimov, Assya, Carli, Cédric, Ahmad, Imran, Bambace, Nadia M., Bernard, Léa, Kiss, Thomas L., Roy, Jean, Roy, Denis-Claude, Lemieux, Sébastien, Perreault, Claude, Rodier, Francis, Dufresne, Simon Frédéric, Busque, Lambert, Lachance, Silvy, Sauvageau, Guy, Cohen, Sandra, and Delisle, Jean-Sébastien

Abstract

•Recipients of UM171-expanded cord blood show robust T cell reconstitution.•Recipients of UM171 grafts show high T cell receptor repertoire diversity post-transplant.•UM171 expansion increases the frequency and potency of common lymphoid progenitors.•UM171 grafts are associated with low rate of severe infections post-transplant.

Published
2024
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24. An Algorithm to Aid in the Investigation of Thalassemia Trait in Multicultural Populations

Author

Kiss, Thomas L., Ali, Mahmoud A. M., Levine, Mitchell, and Lafferty, John D.

Subjects
Thalassemia -- Diagnosis, Anemia -- Diagnosis
Abstract

* Context.--The differentiation between iron deficiency and a thalassemia syndrome is an important consideration in the investigation of microcytic anemia. Objective.--An established statistical method was used to demonstrate the importance of considering ethnic background in combination with mean cell volume (MCV) in the investigation of [Beta]-thalassemia trait in a multicultural urban population. Design.--Posttest probabilities for [Beta]-thalassemia trait were calculated using likelihood ratios for various microcytic MCV ranges in conjunction with published pretest probabilities for [Beta]-thalassemia trait based on ethnic background. Setting.--Regional hemoglobinopathy laboratory, St Joseph's Hospital, Hamilton, Ontario, Canada. Patients.--Patient data were derived from a previously published study. The original study cohort consisted of 789 patients aged 18 years or older who had an MCV less than 80 fL and were referred for routine complete blood count during a 6-month period. Main Outcome Measures.--Posttest probabilities. Results.--Simplified tables for the determination of posttest probabilities for [Beta]-thalassemia trait in individual patients based on ethnic background and MCV are provided. An algorithm to assist in determining when thalassemia investigations are indicated is presented. Conclusions.--A high index of suspicion based on ethnic background and low MCV can provide increased sensitivity and specificity for the detection of thalassemia trait in centers with multicultural populations similar to the study population. (Arch Pathol Lab Med. 2000;124:1320-1323), The thalassemia syndromes are a group of genetic abnormalities that cause deficient production of the [Alpha]-or [Beta]-globin chains of the hemoglobin (Hb) molecule. These abnormalities are prevalent in patients with [...]

Published
2000

25. 396 - Effectiveness of Continuous Infusion of Methylprednisolone for Prevention of Antithymocyte Globulin Infusion-Related Reactions in Preparative Regimens for Allogeneic Hematopoietic Cell Transplantation

Author

Bouchard, Philippe, Brisebois-Boyer, Annie, Charbonneau-Seguin, Noemie, Bonhomme, Valerie, Ahmad, Imran, Bernard, Léa, Bambace, Nadia M., Cohen, Sandra, Delisle, Jean-Sébastien, Kiss, Thomas L., Sauvageau, Guy, Roy, Denis-Claude, Roy, Jean, and Lachance, Silvy

Published
2018
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34. Development and Validation of a Patient-Reported Oral Mucositis Symptom (PROMS) Scale.

Author

Kushner, Jennifer A., Lawrence, Herenia P., Shoval, Irit, Kiss, Thomas L., Devins, Gerald M., Lee, Linda, and Tenenbaum, Howard C.

Subjects
STOMATITIS, BONE marrow transplantation, TRANSPLANTATION of organs, tissues, etc., ORAL diseases, ALIMENTARY canal inflammation
Abstract

Background and Objective: Oral mucositis, a painful condition with potentially life-threatening sequelae, often develops in association with allogeneic bone marrow transplantation. This condition has an adverse impact on the oral-health-related quality of life of patients undergoing marrow transplantation therapy. The purpose of this study was to create and validate a Patient-Reported Oral Mucositis Symptom (PROMS) scale. This scale allows evaluation of symptoms of oral mucositis that threaten quality of life. Materials and Methods: The PROMS scale was compared with previously validated tools measuring quality of life (Functional Assessment of Cancer Therapy—Bone Marrow Transplant), symptoms of depression (Center for Epidemiologic Studies Depression Scale), psychological well-being (Affect Balance Scale) and stressful life events, as well as an objective, clinician-rated assessment of oral mucositis (Visual Analogue Scale—Oral Mucositis Assessment Scale). Thirty-four patients who were to undergo allogeneic bone marrow transplantation at Princess Margaret Hospital in Toronto, Ontario, were enrolled in this validation study. Results: The PROMS scale had high internal reliability, as well as good convergent and discriminant validity relative to subjective measures of well-being. Longitudinal assessments showed that changes in PROMS scores were strongly correlated with changes in clinical assessment of oral mucositis over the first 2 weeks after transplantation, when the onset of oral mucositis typically occurs and the lesions are most severe. Conclusions: Oral mucositis in patients who have undergone bone marrow transplantation can be quantified reliably with the easily administered PROMS scale. The PROMS scale provides a valid measure of the impact of oral mucositis on the oral-health-related quality of life of patients affected by this malady. [ABSTRACT FROM AUTHOR]

Published
2008

35. Single UM171‐ExpandedCord Blood Transplants Support Robust T‐CellReconstitution with Low Rates of Severe Infections

Author

Dumont‐Lagacé, Maude, Li, Qi, Tanguay, Mégane, Chagraoui, Jalila, Kientega, Tibila, Cardin, Guillaume B., Brasey, Ann, Trofimov, Assya, Carli, Cédric, Ahmad, Imran, Bambace, Nadia, Bernard, Léa, Kiss, Thomas L., Roy, Jean, Roy, Denis‐Claude, Lemieux, Sébastien, Perreault, Claude, Rodier, Francis, Dufresne, Simon Frédéric, Busque, Lambert, Lachance, Silvy, Sauvageau, Guy, Cohen, Sandra, and Delisle, Jean‐Sébastien

Published
2020
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36. Development and validation of a Patient-Reported Oral Mucositis Symptom (PROMS) scale.

Author

Kushner JA, Lawrence HP, Shoval I, Kiss TL, Devins GM, Lee L, and Tenenbaum HC

Subjects
Female, Humans, Leukemia therapy, Lymphoma therapy, Male, Mucositis etiology, Reproducibility of Results, Self-Assessment, Severity of Illness Index, Statistics, Nonparametric, Stomatitis etiology, Surveys and Questionnaires, Bone Marrow Transplantation adverse effects, Mucositis psychology, Quality of Life, Stomatitis psychology, Transplantation Conditioning adverse effects
Abstract

Background and Objective: Oral mucositis, a painful condition with potentially life-threatening sequelae, often develops in association with allogeneic bone marrow transplantation. This condition has an adverse impact on the oral-health-related quality of life of patients undergoing marrow transplantation therapy. The purpose of this study was to create and validate a Patient-Reported Oral Mucositis Symptom (PROMS) scale. This scale allows evaluation of symptoms of oral mucositis that threaten quality of life., Materials and Methods: The PROMS scale was compared with previously validated tools measuring quality of life (Functional Assessment of Cancer Therapy--Bone Marrow Transplant), symptoms of depression (Center for Epidemiologic Studies Depression Scale), psychological well-being (Affect Balance Scale) and stressful life events, as well as an objective, clinician-rated assessment of oral mucositis (Visual Analogue Scale--Oral Mucositis Assessment Scale). Thirty-four patients who were to undergo allogeneic bone marrow transplantation at Princess Margaret Hospital in Toronto, Ontario, were enrolled in this validation study., Results: The PROMS scale had high internal reliability, as well as good convergent and discriminant validity relative to subjective measures of well-being. Longitudinal assessments showed that changes in PROMS scores were strongly correlated with changes in clinical assessment of oral mucositis over the first 2 weeks after transplantation, when the onset of oral mucositis typically occurs and the lesions are most severe., Conclusions: Oral mucositis in patients who have undergone bone marrow transplantation can be quantified reliably with the easily administered PROMS scale. The PROMSscale provides a valid measure of the impact of oral mucositis on the oral-health-related quality of life of patients affected by this malady.

Published
2008

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